Inherited defects in pedigree dogs. Part 2: disorders that are not related to breed standards

Summers, Jennifer F., Diesel, Gillian, Asher, Lucy , McGreevy, Paul D. and Collins, Lisa M. (2010) Inherited defects in pedigree dogs. Part 2: disorders that are not related to breed standards. The Veterinary Journal, 183 (1). pp. 39-45. ISSN 1090-0233

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Recent debate concerning health problems in pedigree animals has highlighted gaps in current knowledge of the prevalence, severity and welfare implications of deleterious inherited traits within the pedigree-dog population. In this second part of a two-part review, inherited disorders in the top 50 UK Kennel Club registered breeds were researched using systematic searches of existing databases. A set of inclusion and exclusion criteria, including an evidence strength scale (SEHB), were applied to search results. A total of 312 non-conformation linked inherited disorders was identified, with German shepherd dogs and Golden retrievers associated with the greatest number of disorders. The most commonly reported mode of inheritance was autosomal recessive (71%; 57 breed-disorder combinations), and the most common primarily affected body system was the nervous sensory system. To provide a true assessment of the scale of inherited disorders in the pedigree dogs studied more effort is required to collect accurate prevalence data.

Keywords:animal welfare, article, breed, data analysis, disease severity, dog, genetic disorder, genetic predisposition, information retrieval, morphology, nonhuman, pedigree, prevalence, scoring system, statistical analysis, United Kingdom, Animal Welfare, Animals, Breeding, Dog Diseases, Dogs, Female, Genetic Predisposition to Disease, Genetic Variation, Genetics, Population, Inbreeding, Male, Quality of Life, Severity of Illness Index, Statistics, Nonparametric, Canis familiaris
Subjects:D Veterinary Sciences, Agriculture and related subjects > D300 Animal Science
D Veterinary Sciences, Agriculture and related subjects > D328 Animal Welfare
Divisions:College of Science > School of Life Sciences
ID Code:11923
Deposited On:16 Sep 2013 17:18

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