Madan, Babita, Singh, Ishwar, Kumar, Ajit , Prasad, Ashok K., Raj, Hanumantharao G., Parmar, Virinder S. and Ghosh, Balaram (2002) Xanthones as inhibitors of microsomal lipid peroxidation and TNF-alpha induced ICAM-1 expression on human umbilical vein endothelial cells (HUVECs). Bioorganic and Medicinal Chemistry, 10 (11). pp. 3431-3436. ISSN 0968-0896
Full content URL: http://dx.doi.org/10.1016/S0968-0896(02)00262-6
Full text not available from this repository.
| Item Type: | Article |
|---|---|
| Item Status: | Live Archive |
Abstract
Xanthones bearing different functionalities, namely 1-hydroxyxanthone (1), 3-hydroxyxanthone (2), 1,4-dihydroxyxanthone (3), 2,6-dihydroxyxanthone (4), 1,2-diacetoxyxanthone (5), 2,6-diacetoxyxanthone (6), 3-methoxyxanthone (7), 1,3,7-trimethoxyxanthone (8) and 1,5-dihydroxy-6-methoxyxanthone (9) were synthesised and examined for their effect on nicotinamide adenine dinucleotide phosphate (NADPH)-catalysed liver microsomal lipid peroxidation and on tumour necrosis factor-alpha (TNF-alpha) induced expression of intercellular adhesion moledule-1 (ICAM-1) on endothelial cells, with a view to establish structure-activity relationship. Hydroxy- and acetoxyxanthones showed potent inhibitory effects on NADPH-catalysed lipid peroxidation and TNF-a induced expression of ICAM-1 on endothelial cells. (C) 2002 Elsevier Science Ltd. All rights reserved.
| Keywords: | Xanthone |
|---|---|
| Subjects: | B Subjects allied to Medicine > B200 Pharmacology, Toxicology and Pharmacy |
| Divisions: | College of Science > School of Pharmacy |
| ID Code: | 11312 |
| Deposited On: | 24 Jul 2013 07:54 |
Repository Staff Only: item control page