Metal free, "click and click-click'' conjugation of ribonucleosides and 2'-OMe oligoribonucleotides on the solid phase

Singh, Ishwar and Heaney, Frances (2010) Metal free, "click and click-click'' conjugation of ribonucleosides and 2'-OMe oligoribonucleotides on the solid phase. Organic and Biomolecular Chemistry, 8 (2). pp. 451-456. ISSN 1477-0520

Full content URL: http://dx.doi.org/10.1039/b918463e

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Item Type:Article
Item Status:Live Archive

Abstract

A fast and practical metal free conjugation of ribonucleosides and 2'-OMe 4-mer oligoribonucleotides has been accomplished by a nitrile oxide alkyne click cycloaddition reaction on the solid-phase, the methodology is suited to modification at either, or both, the 3'- or the 5'-terminus of the oligoribonucleotide substrate.

Additional Information:First published online 26 Nov 2009
Keywords:Ribonucleosides, Oligoribonucleotides, Nucleosides, Nucleotides
Subjects:B Subjects allied to Medicine > B200 Pharmacology, Toxicology and Pharmacy
Divisions:College of Science > School of Pharmacy
ID Code:11298
Deposited On:24 Jul 2013 09:24

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