Singh, Ishwar and Heaney, Frances (2010) Metal free, "click and click-click'' conjugation of ribonucleosides and 2'-OMe oligoribonucleotides on the solid phase. Organic and Biomolecular Chemistry, 8 (2). pp. 451-456. ISSN 1477-0520
Full content URL: http://dx.doi.org/10.1039/b918463e
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| Item Type: | Article |
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| Item Status: | Live Archive |
Abstract
A fast and practical metal free conjugation of ribonucleosides and 2'-OMe 4-mer oligoribonucleotides has been accomplished by a nitrile oxide alkyne click cycloaddition reaction on the solid-phase, the methodology is suited to modification at either, or both, the 3'- or the 5'-terminus of the oligoribonucleotide substrate.
| Additional Information: | First published online 26 Nov 2009 |
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| Keywords: | Ribonucleosides, Oligoribonucleotides, Nucleosides, Nucleotides |
| Subjects: | B Subjects allied to Medicine > B200 Pharmacology, Toxicology and Pharmacy |
| Divisions: | College of Science > School of Pharmacy |
| ID Code: | 11298 |
| Deposited On: | 24 Jul 2013 09:24 |
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