Algay, Virginie, Singh, Ishwar and Heaney, Frances (2010) Nucleoside and nucleotide analogues by catalyst free Huisgen nitrile oxide-alkyne 1,3-dipolar cycloaddition. Organic and Biomolecular Chemistry, 8 (2). pp. 391-397. ISSN 1477-0520
Full content URL: http://dx.doi.org/10.1039/b917450h
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| Item Type: | Article |
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| Item Status: | Live Archive |
Abstract
An efficient, catalyst free, 1,3-dipolar cycloaddition strategy to conjugate nucleosides and nucleotides with isoxazoles under atmospheric conditions and in an aqueous environment is reported. The protocol involves chloramine-T as a practical reagent to induce in situ nitrile oxide formation and the alkyne partner is attached to the sugar residue or the nucleobase. The reactions are regiospecific, fast and high yielding.
| Additional Information: | First published online 28 Oct 2009 |
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| Keywords: | Nucleosides, Nucleotides |
| Subjects: | B Subjects allied to Medicine > B200 Pharmacology, Toxicology and Pharmacy |
| Divisions: | College of Science > School of Pharmacy |
| ID Code: | 11297 |
| Deposited On: | 24 Jul 2013 09:23 |
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