Algay, Virginie, Singh, Ishwar and Heaney, Frances (2010) Nucleoside and nucleotide analogues by catalyst free Huisgen nitrile oxide-alkyne 1,3-dipolar cycloaddition. Organic and Biomolecular Chemistry, 8 (2). pp. 391-397. ISSN 1477-0520
Full content URL: http://dx.doi.org/10.1039/b917450h
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Item Type: | Article |
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Item Status: | Live Archive |
Abstract
An efficient, catalyst free, 1,3-dipolar cycloaddition strategy to conjugate nucleosides and nucleotides with isoxazoles under atmospheric conditions and in an aqueous environment is reported. The protocol involves chloramine-T as a practical reagent to induce in situ nitrile oxide formation and the alkyne partner is attached to the sugar residue or the nucleobase. The reactions are regiospecific, fast and high yielding.
Additional Information: | First published online 28 Oct 2009 |
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Keywords: | Nucleosides, Nucleotides |
Subjects: | B Subjects allied to Medicine > B200 Pharmacology, Toxicology and Pharmacy |
Divisions: | College of Science > School of Pharmacy |
ID Code: | 11297 |
Deposited On: | 24 Jul 2013 09:23 |
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