Directed assembly of DNA-functionalized gold nanoparticles using pyrrole-imidazole polyamides

Krpetic, Zeljka, Singh, Ishwar, Su, Wu , Guerrini, Luca, Faulds, Karen, Burley, Glenn A. and Graham, Duncan (2012) Directed assembly of DNA-functionalized gold nanoparticles using pyrrole-imidazole polyamides. Journal of the American Chemical Society, 134 (20). pp. 8356-8359. ISSN 0002-7863

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Traditional methods for the construction of nanoparticle arrays and lattices exploit Watson-Crick base pairing of single-stranded DNA sequences as a proxy for self-assembly. Although this approach has been utilized in a variety of applications in nanoassembly, diagnostics, and biomedicine, the diversity of this recognition lexicon, could be considerably increased by developing strategies that recognize the base-pairing landscape of double-stranded DNA (dsDNA) sequences. Herein we describe the first report of programmed gold nanoparticle (GNP) aggregation directed by the recognition of dsDNA sequences using pyrrole-imidazole polyamide-GNP (PA-GNP) conjugates. We demonstrate the reversibility and selectivity of this strategy for forming GNP aggregates in the presence of fully matched dsDNA sequences relative to dsDNA sequences containing one- and two-base-pair mismatches.

Additional Information:Publication Date (Web): May 7, 2012
Subjects:B Subjects allied to Medicine > B200 Pharmacology, Toxicology and Pharmacy
Divisions:College of Science > School of Pharmacy
ID Code:11289
Deposited On:24 Jul 2013 15:19

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