sen Bhattacharya, Basabdatta, Coyle, Damien and Maguire, Liam (2011) Synaptic deficiency in Alzheimer disease and its implications on thalamic and cortical oscillations: a study using a neural mass model. In: 11th UKCI workshop, 7th-9th September 2011, Manchester.
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| Item Type: | Conference or Workshop contribution (Paper) |
|---|---|
| Item Status: | Live Archive |
Abstract
This paper studies the effects of varying the total
number of synapses in a computational model of a thalamocortico-thalamic circuitry. The aim is to study overall EEG
slowing in Alzheimer disease (AD) indicated by an increase in
power within the delta (0.5-3 Hz) and theta (3.5-7 Hz) bands
and a decrease in power within the alpha (7.5-13 Hz) and beta
(13.5-20 Hz) frequency bands. We observe a systematic shift
in peak power of the model output from the highest (beta) to
the lowest (delta) frequency band with intra-thalamic synaptic
depletion. This conforms to an overall EEG slowing observed
in AD. Furthermore, the power in all bands stabilise beyond
a certain threshold and do not change with further increase
in synaptic connectivity. This implies redundancy in synaptic
pathways of the thalamo-cortical circuitry and conforms to the
theory of cognitive reserve in AD.
| Keywords: | brain oscillations, Alzheimers Disease, neural mass model |
|---|---|
| Subjects: | G Mathematical and Computer Sciences > G730 Neural Computing |
| Divisions: | College of Science > School of Engineering |
| Related URLs: | |
| ID Code: | 10599 |
| Deposited On: | 30 Jun 2013 19:37 |
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