Ocular flutter associated with a localized lesion in the paramedian pontine reticular formation

Schon, F., Hodgson, T. L., Mort, D. and Kennard, C. (2001) Ocular flutter associated with a localized lesion in the paramedian pontine reticular formation. Annals of Neurology, 50 (3). pp. 413-416. ISSN 0364-5134

Full content URL: http://dx.doi.org/10.1002/ana.1140

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Item Type:Article
Item Status:Live Archive


Ocular flutter is a rare horizontal eye movement disorder characterized by rapid saccadic oscillations. It has been hypothesized that it is caused by loss of "pause" neuronal inhibition of "burst" neuron function in the paramedian pontine reticular formation (PPRF), however, there have been no imaging studies confirming such anatomical localization. We report the case of a woman with an acute attack of multiple sclerosis associated both with ocular flutter and a circumscribed pontine lesion, mainly involving the PPRF on magnetic resonance imaging. As she recovered from the attack, both the midline pontine lesion and the ocular flutter dramatically improved. This case is the first clear evidence that at least some cases of ocular flutter are due to lesions involving the PPRF.

Keywords:adult, article, brain injury, brain nerve cell, case report, cell function, eye movement disorder, female, human, multiple sclerosis, nuclear magnetic resonance imaging, ocular flutter, pons reticular formation, priority journal, radiodiagnosis, saccadic eye movement, Adult, Humans, Magnetic Resonance Imaging, Medulla Oblongata, Multiple Sclerosis, Relapsing-Remitting, Ocular Motility Disorders, Pons, Reticular Formation
Subjects:C Biological Sciences > C800 Psychology
C Biological Sciences > C850 Cognitive Psychology
Divisions:College of Social Science > School of Psychology
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ID Code:10547
Deposited On:10 Jul 2013 12:08

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