Items where Subject is "F163 Bio-organic Chemistry"

Up a level
Export as [feed] Atom [feed] RSS 1.0 [feed] RSS 2.0
Group by: Creators | Keywords | Item Type
Acridine-HSP90 Anti-tumor activities Antibody labelling Binding affinity screening Bio-target identification Bio-targeting Bioinorganic chemistry Biomimetic Synthesis Biomimetic synthesis Biomimicry Biomolecular identification Biosynthesis Biotarget identification Chemical characterisation Chemical modification Chemical proteomics Click Chemistry DNA Density functional theory Deoxy sugars Diels-Alder Drug discovery Drug off-targets Enantiodivergent Enzymes Epoxidation reaction Fatty acid synthase Fluorescent immuno-affinity label Fluorescent-labeled probes GPI anchor Glycobiology Glycolipids High-throughput Immuno-affinity screening Inositol JCNotOpen JCOpen Lead discovery Light harvesting protein Lipid II MRSA Malaria Maleimide reagents Metal free click chemistry Metal free click chemistry in water Mevalonate Mode-of-action NMR Natural product Natural products NotOAChecked Organic synthesis Orlistat Peptides. PEG Plasmodium falciparum Self assembly Teixobactin Teixobactins Telomerase Tetraols Total synthesis Total synthesis studies Transannular ring-opening Triazole VRE Verapamil anti-tumour agents antibiotic resistance antibiotics antiparasitic agents benzenoids bioimaging cell death click chemistry cyclization dimerization diradicals drug discovery enediynes fluorescent-labelled chloroquine fluorescent-tagged drug probes hyperpolarisation malaria membrane anchor monochlorination orlistat parasitology phenotypic screening prion programmed cell death proteomics trypanosomiasis x-ray crystallography
Number of items at this level: 118.

Acridine-HSP90

Roe, S., Gunaratnam, M., Spiteri, C., Sharma, Pallavi, Alharthy, R. D., Neidle, S. and Moses, J. E. (2015) Synthesis and biological evaluation of hybrid acridine-HSP90 ligand conjugates as telomerase inhibitors. Organic and Biomolecular Chemistry, 13 . pp. 8500-8504. ISSN 1477-0520

Anti-tumor activities

Yang, Peng-Yu, Liu, Kai, Ngai, Mun Hong, Lear, Martin J., Wenk, Markus R. and Yao, Shao Q. (2010) Activity-based proteome profiling of potential cellular targets of Orlistat - an FDA-approved drug with anti-tumor activities. Journal of the American Chemical Society, 132 (2). pp. 656-666. ISSN 0002-7863

Antibody labelling

Song, Hong Y., Ngai, Mun H., Song, Zhen Y., MacAry, Paul A., Hobley, Jonathan and Lear, Martin J. (2009) Practical synthesis of maleimides and coumarin-linked probes for protein and antibody labelling via reduction of native disulfides. Organic & Biomolecular Chemistry, 7 (17). pp. 3400-3406. ISSN 1477-0520

Binding affinity screening

Rodríguez, Abimael D., Lear, Martin J. and La Clair, James J. (2008) Identification of the binding of sceptrin to MreB via a bidirectional affinity protocol. Journal of the American Chemical Society, 130 (23). pp. 7256-7258. ISSN 0002-7863

Bio-target identification

Lear, Martin (2011) Total synthesis and drug pursuits: laetirobins, lipstatins, platensimycins [ACP Tour, Japan]. In: Asia Core Program Lectureship Tour of Japan, 18-22 Dec 2011, Nagoya, Tokyo, and Tohoku, Japan.

Bio-targeting

Lear, Martin (2010) Exploring the glycolipidome via chemical mimicry. In: EMBO Conference Series: Chemical Biology 2010, 22 - 25 Sep 2010, EMBL Heidelberg, Germany.

Bioinorganic chemistry

Caserta, Giorgio, Pecqueur, Ludovic, Adamska-Venkatesh, Agnieszka, Papini, Cecilia, Roy, Souvik, Artero, Vincent, Atta, Mohamed, Reijerse, Edward, Lubitz, Wolfgang and Fontecave, Marc (2017) Structural and functional characterization of the hydrogenase-maturation HydF protein. Nature Chemical Biology, 13 (7). pp. 779-784. ISSN 1552-4450

Biomimetic Synthesis

Lear, Martin (2010) Exploring the glycolipidome via chemical mimicry. In: EMBO Conference Series: Chemical Biology 2010, 22 - 25 Sep 2010, EMBL Heidelberg, Germany.

Biomimetic synthesis

Simon, Oliver, Reux, Bastien, La Clair, James J. and Lear, Martin J. (2010) Total synthesis confirms laetirobin as a formal Diels-Alder adduct. Chemistry - An Asian Journal, 5 (2). pp. 342-351. ISSN 1861-4728

Biomimicry

Lear, Martin (2010) Exploring the glycolipidome via chemical mimicry. In: EMBO Conference Series: Chemical Biology 2010, 22 - 25 Sep 2010, EMBL Heidelberg, Germany.

Lear, Martin, Reux, Bastien and Sekar, Karthik (2012) Chemical synthesis, modification and mimicry of the GPI anchor. In: GPI membrane anchors: the much needed link. Bentham Science Publishers Ltd, pp. 64-82. ISBN 9781608051236

Biomolecular identification

Lear, Martin (2010) Exploring the glycolipidome via chemical mimicry. In: EMBO Conference Series: Chemical Biology 2010, 22 - 25 Sep 2010, EMBL Heidelberg, Germany.

Biosynthesis

Pasari, Sandip, Ismail, Shareef M., Wenk, Markus R. and Lear, Martin (2015) Preparation of azide biosynthetic surrogates of myo-Inositol. Tetrahedron Letters, 56 (20). pp. 2597-2601. ISSN 0040-4039

Biotarget identification

Rodríguez, Abimael D., Lear, Martin J. and La Clair, James J. (2008) Identification of the binding of sceptrin to MreB via a bidirectional affinity protocol. Journal of the American Chemical Society, 130 (23). pp. 7256-7258. ISSN 0002-7863

Chemical characterisation

Lear, Martin J., Simon, Oliver, Foley, Timothy L., Burkart, Michael D., Baiga, Thomas J., Noel, Joseph P., DiPasquale, Antonio G., Rheingold, Arnold L. and La Clair, James J. (2009) Laetirobin from the parasitic growth of Laetiporus sulphurous on Robinia pseudoacacia. Journal of Natural Products, 72 (11). pp. 1980-1987. ISSN 0163-3864

Chemical modification

Caserta, Giorgio, Pecqueur, Ludovic, Adamska-Venkatesh, Agnieszka, Papini, Cecilia, Roy, Souvik, Artero, Vincent, Atta, Mohamed, Reijerse, Edward, Lubitz, Wolfgang and Fontecave, Marc (2017) Structural and functional characterization of the hydrogenase-maturation HydF protein. Nature Chemical Biology, 13 (7). pp. 779-784. ISSN 1552-4450

Chemical proteomics

Lear, Martin and Yao, Shao Q. (2010) New directions for old drugs. Project Report. National University of Singapore, Singapore.

Ngai, Mun H., Yang, Peng-Yu, Liu, Kai, Shen, Yuan, Wenk, Markus R., Yao, Shao Q. and Lear, Martin J. (2010) Click-based synthesis and proteomic profiling of lipstatin analogues. Chemical Communications, 46 (44). p. 8335. ISSN 1359-7345

Yang, Peng-Yu, Liu, Kai, Ngai, Mun Hong, Lear, Martin J., Wenk, Markus R. and Yao, Shao Q. (2010) Activity-based proteome profiling of potential cellular targets of Orlistat - an FDA-approved drug with anti-tumor activities. Journal of the American Chemical Society, 132 (2). pp. 656-666. ISSN 0002-7863

Click Chemistry

Roe, S., Gunaratnam, M., Spiteri, C., Sharma, Pallavi, Alharthy, R. D., Neidle, S. and Moses, J. E. (2015) Synthesis and biological evaluation of hybrid acridine-HSP90 ligand conjugates as telomerase inhibitors. Organic and Biomolecular Chemistry, 13 . pp. 8500-8504. ISSN 1477-0520

DNA

Freeman, Colin, Cheallaigh, Aisling Ni, Singh, Ishwar and Heaney, Frances (2015) Isoxazole linked oligonucleotide conjugates by on resin and previously clicked nitrile oxide alkyne cycloadditions. Collection of Czechoslovak Chemical Communications, 12 . p. 333. ISSN 0010-0765

Henry, Sarah L., Withers, Jamie M., Singh, Ishwar, Cooper, Jonathan M., Clark, Alasdair W., Burley, Glenn A. and Cogdell, Richard J. (2015) DNA-directed spatial assembly of photosynthetic light-harvesting proteins. Organic & Biomolecular Chemistry, 14 (4). pp. 1359-1362. ISSN 1477-0520

Singh, Ishwar, Heaney, Frances, Batchelor, Caroline and Vyle, Joseph S. (2015) Metal free click chemistry on nucleosides and oligonucleotides. Collection of Czechoslovak Chemical Communications, 10 . p. 451. ISSN 0010-0765

Density functional theory

Kyne, S. H., Miles, J. A. L., Percy, J. M. and Singh, K. (2012) Executing and rationalizing the synthesis of a difluorinated analogue of a ring-expanded calystegine B2. Journal of Organic Chemistry, 77 (2). pp. 991-998. ISSN 0022-3263

Deoxy sugars

Pasari, Sandip, Ismail, Shareef M., Wenk, Markus R. and Lear, Martin (2015) Preparation of azide biosynthetic surrogates of myo-Inositol. Tetrahedron Letters, 56 (20). pp. 2597-2601. ISSN 0040-4039

Diels-Alder

Simon, Oliver, Reux, Bastien, La Clair, James J. and Lear, Martin J. (2010) Total synthesis confirms laetirobin as a formal Diels-Alder adduct. Chemistry - An Asian Journal, 5 (2). pp. 342-351. ISSN 1861-4728

Drug discovery

Lear, Martin (2012) Total synthesis and drug pursuits: laetirobins, lipstatins, platensimycins. In: ZiNG Natural Products Conference 2012: Natural Products Synthesis and Biosynthesis, 10 - 13 February 2012, Lanzarote, Spain.

Lear, Martin (2011) Total synthesis and drug pursuits: laetirobins, lipstatins, platensimycins [ACP Tour, Japan]. In: Asia Core Program Lectureship Tour of Japan, 18-22 Dec 2011, Nagoya, Tokyo, and Tohoku, Japan.

Drug off-targets

Yang, Peng-Yu, Liu, Kai, Ngai, Mun Hong, Lear, Martin J., Wenk, Markus R. and Yao, Shao Q. (2010) Activity-based proteome profiling of potential cellular targets of Orlistat - an FDA-approved drug with anti-tumor activities. Journal of the American Chemical Society, 132 (2). pp. 656-666. ISSN 0002-7863

Enantiodivergent

Ghosh, Shibaji K., Butler, Mark S. and Lear, Martin J. (2012) Synthesis of 2-C-methylerythritols and 2-C-methylthreitols via enantiodivergent Sharpless dihydroxylation of trisubstituted olefins. Tetrahedron Letters, 53 (22). pp. 2706-2708. ISSN 0040-4039

Enzymes

Caserta, Giorgio, Pecqueur, Ludovic, Adamska-Venkatesh, Agnieszka, Papini, Cecilia, Roy, Souvik, Artero, Vincent, Atta, Mohamed, Reijerse, Edward, Lubitz, Wolfgang and Fontecave, Marc (2017) Structural and functional characterization of the hydrogenase-maturation HydF protein. Nature Chemical Biology, 13 (7). pp. 779-784. ISSN 1552-4450

Fernandez Diaz-Rullo, Fernando, Zamberlan, Francesco, Mewis, Ryan E., Fekete, Marianna, Broche, Lionel, Cheyne, Lesley A., Dall'Angelo, Sergio, Duckett, Simon B., Dawson, Dana and Zanda, Matteo (2017) Synthesis and hyperpolarisation of eNOS substrates for quantification of NO production by 1H NMR spectroscopy. Bioorganic & Medicinal Chemistry, 25 (10). pp. 2730-2742. ISSN 0968-0896

Epoxidation reaction

Kyne, S. H., Miles, J. A. L., Percy, J. M. and Singh, K. (2012) Executing and rationalizing the synthesis of a difluorinated analogue of a ring-expanded calystegine B2. Journal of Organic Chemistry, 77 (2). pp. 991-998. ISSN 0022-3263

Fatty acid synthase

Ngai, Mun H., Yang, Peng-Yu, Liu, Kai, Shen, Yuan, Wenk, Markus R., Yao, Shao Q. and Lear, Martin J. (2010) Click-based synthesis and proteomic profiling of lipstatin analogues. Chemical Communications, 46 (44). p. 8335. ISSN 1359-7345

Fluorescent immuno-affinity label

Rodríguez, Abimael D., Lear, Martin J. and La Clair, James J. (2008) Identification of the binding of sceptrin to MreB via a bidirectional affinity protocol. Journal of the American Chemical Society, 130 (23). pp. 7256-7258. ISSN 0002-7863

Fluorescent-labeled probes

Song, Hong Y., Ngai, Mun H., Song, Zhen Y., MacAry, Paul A., Hobley, Jonathan and Lear, Martin J. (2009) Practical synthesis of maleimides and coumarin-linked probes for protein and antibody labelling via reduction of native disulfides. Organic & Biomolecular Chemistry, 7 (17). pp. 3400-3406. ISSN 1477-0520

GPI anchor

Hicks, Matthew R., Gill, Andrew C., Bath, Imanpreet K., Rullay, Atvinder K., Sylvester, Ian D., Crout, David H. and Pinheiro, Teresa J. T. (2006) Synthesis and structural characterization of a mimetic membrane-anchored prion protein. FEBS Journal, 273 (6). pp. 1285-1299. ISSN 1742-464X

Glycobiology

Lear, Martin, Reux, Bastien and Sekar, Karthik (2012) Chemical synthesis, modification and mimicry of the GPI anchor. In: GPI membrane anchors: the much needed link. Bentham Science Publishers Ltd, pp. 64-82. ISBN 9781608051236

Glycolipids

Lear, Martin, Reux, Bastien and Sekar, Karthik (2012) Chemical synthesis, modification and mimicry of the GPI anchor. In: GPI membrane anchors: the much needed link. Bentham Science Publishers Ltd, pp. 64-82. ISBN 9781608051236

Pasari, Sandip, Ismail, Shareef M., Wenk, Markus R. and Lear, Martin (2015) Preparation of azide biosynthetic surrogates of myo-Inositol. Tetrahedron Letters, 56 (20). pp. 2597-2601. ISSN 0040-4039

High-throughput

Ch'ng, Jun-Hong, Mok, Sachel, Bozdech, Zbynek, Lear, Martin James, Boudhar, Aicha, Russell, Bruce, Nosten, Francois and Tan, Kevin Shyong-Wei (2013) A whole cell pathway screen reveals seven novel chemosensitizers to combat chloroquine resistant malaria. Scientific Reports, 3 (1734). ISSN 2045-2322

Immuno-affinity screening

Lear, Martin J., Simon, Oliver, Foley, Timothy L., Burkart, Michael D., Baiga, Thomas J., Noel, Joseph P., DiPasquale, Antonio G., Rheingold, Arnold L. and La Clair, James J. (2009) Laetirobin from the parasitic growth of Laetiporus sulphurous on Robinia pseudoacacia. Journal of Natural Products, 72 (11). pp. 1980-1987. ISSN 0163-3864

Inositol

Pasari, Sandip, Ismail, Shareef M., Wenk, Markus R. and Lear, Martin (2015) Preparation of azide biosynthetic surrogates of myo-Inositol. Tetrahedron Letters, 56 (20). pp. 2597-2601. ISSN 0040-4039

JCNotOpen

Pasari, Sandip, Ismail, Shareef M., Wenk, Markus R. and Lear, Martin (2015) Preparation of azide biosynthetic surrogates of myo-Inositol. Tetrahedron Letters, 56 (20). pp. 2597-2601. ISSN 0040-4039

JCOpen

Parmar, Anish, Iyer, Abhishek, Vincent, Charlotte, Van Lysebetten, Dorien, Prior, Stephen H., Madder, Annemieke, Taylor, Edward J. and Singh, Ishwar (2016) Efficient total syntheses and biological activities of two teixobactin analogues. Chemical Communications, 52 (36). pp. 6060-6063. ISSN 1359-7345

Lead discovery

Lear, Martin J., Simon, Oliver, Foley, Timothy L., Burkart, Michael D., Baiga, Thomas J., Noel, Joseph P., DiPasquale, Antonio G., Rheingold, Arnold L. and La Clair, James J. (2009) Laetirobin from the parasitic growth of Laetiporus sulphurous on Robinia pseudoacacia. Journal of Natural Products, 72 (11). pp. 1980-1987. ISSN 0163-3864

Light harvesting protein

Henry, Sarah L., Withers, Jamie M., Singh, Ishwar, Cooper, Jonathan M., Clark, Alasdair W., Burley, Glenn A. and Cogdell, Richard J. (2015) DNA-directed spatial assembly of photosynthetic light-harvesting proteins. Organic & Biomolecular Chemistry, 14 (4). pp. 1359-1362. ISSN 1477-0520

Lipid II

Fiers, William D., Craighead, Mark and Singh, Ishwar (2017) Teixobactin and its analogues: a new hope in antibiotic discovery. ACS Infectious Diseases, 3 (10). pp. 688-690. ISSN 2373-8227

MRSA

Singh, Ishwar and Walden, Benjamin (2018) Simplified teixobactin analogues to target superbugs. Future Medicinal Chemistry, 10 (2). ISSN 1756-8919

Malaria

Ghosh, Shibaji K., Butler, Mark S. and Lear, Martin J. (2012) Synthesis of 2-C-methylerythritols and 2-C-methylthreitols via enantiodivergent Sharpless dihydroxylation of trisubstituted olefins. Tetrahedron Letters, 53 (22). pp. 2706-2708. ISSN 0040-4039

Maleimide reagents

Song, Hong Y., Ngai, Mun H., Song, Zhen Y., MacAry, Paul A., Hobley, Jonathan and Lear, Martin J. (2009) Practical synthesis of maleimides and coumarin-linked probes for protein and antibody labelling via reduction of native disulfides. Organic & Biomolecular Chemistry, 7 (17). pp. 3400-3406. ISSN 1477-0520

Metal free click chemistry

Freeman, Colin, Cheallaigh, Aisling Ni, Singh, Ishwar and Heaney, Frances (2015) Isoxazole linked oligonucleotide conjugates by on resin and previously clicked nitrile oxide alkyne cycloadditions. Collection of Czechoslovak Chemical Communications, 12 . p. 333. ISSN 0010-0765

Metal free click chemistry in water

Singh, Ishwar, Heaney, Frances, Batchelor, Caroline and Vyle, Joseph S. (2015) Metal free click chemistry on nucleosides and oligonucleotides. Collection of Czechoslovak Chemical Communications, 10 . p. 451. ISSN 0010-0765

Mevalonate

Ghosh, Shibaji K., Butler, Mark S. and Lear, Martin J. (2012) Synthesis of 2-C-methylerythritols and 2-C-methylthreitols via enantiodivergent Sharpless dihydroxylation of trisubstituted olefins. Tetrahedron Letters, 53 (22). pp. 2706-2708. ISSN 0040-4039

Mode-of-action

Lear, Martin (2013) Synthetic ventures into the platensimycins, bielschowskysins, lipstatins, and enediynes. In: Lecture Tour, July 2013, RIKEN, Waseda University, Keio University, Sophia University, Japan.

NMR

Fernandez Diaz-Rullo, Fernando, Zamberlan, Francesco, Mewis, Ryan E., Fekete, Marianna, Broche, Lionel, Cheyne, Lesley A., Dall'Angelo, Sergio, Duckett, Simon B., Dawson, Dana and Zanda, Matteo (2017) Synthesis and hyperpolarisation of eNOS substrates for quantification of NO production by 1H NMR spectroscopy. Bioorganic & Medicinal Chemistry, 25 (10). pp. 2730-2742. ISSN 0968-0896

Natural product

Ngai, Mun H., Yang, Peng-Yu, Liu, Kai, Shen, Yuan, Wenk, Markus R., Yao, Shao Q. and Lear, Martin J. (2010) Click-based synthesis and proteomic profiling of lipstatin analogues. Chemical Communications, 46 (44). p. 8335. ISSN 1359-7345

Simon, Oliver, Reux, Bastien, La Clair, James J. and Lear, Martin J. (2010) Total synthesis confirms laetirobin as a formal Diels-Alder adduct. Chemistry - An Asian Journal, 5 (2). pp. 342-351. ISSN 1861-4728

Natural products

Lear, Martin (2010) Exploring the glycolipidome via chemical mimicry. In: EMBO Conference Series: Chemical Biology 2010, 22 - 25 Sep 2010, EMBL Heidelberg, Germany.

Lear, Martin (2013) Synthetic ventures into the platensimycins, bielschowskysins, lipstatins, and enediynes. In: Lecture Tour, July 2013, RIKEN, Waseda University, Keio University, Sophia University, Japan.

Lear, Martin (2011) Total synthesis and drug pursuits: laetirobins, lipstatins, platensimycins [ACP Tour, Japan]. In: Asia Core Program Lectureship Tour of Japan, 18-22 Dec 2011, Nagoya, Tokyo, and Tohoku, Japan.

Lear, Martin J., Simon, Oliver, Foley, Timothy L., Burkart, Michael D., Baiga, Thomas J., Noel, Joseph P., DiPasquale, Antonio G., Rheingold, Arnold L. and La Clair, James J. (2009) Laetirobin from the parasitic growth of Laetiporus sulphurous on Robinia pseudoacacia. Journal of Natural Products, 72 (11). pp. 1980-1987. ISSN 0163-3864

Rodríguez, Abimael D., Lear, Martin J. and La Clair, James J. (2008) Identification of the binding of sceptrin to MreB via a bidirectional affinity protocol. Journal of the American Chemical Society, 130 (23). pp. 7256-7258. ISSN 0002-7863

NotOAChecked

Freeman, Colin, Cheallaigh, Aisling Ni, Singh, Ishwar and Heaney, Frances (2015) Isoxazole linked oligonucleotide conjugates by on resin and previously clicked nitrile oxide alkyne cycloadditions. Collection of Czechoslovak Chemical Communications, 12 . p. 333. ISSN 0010-0765

Henry, Sarah L., Withers, Jamie M., Singh, Ishwar, Cooper, Jonathan M., Clark, Alasdair W., Burley, Glenn A. and Cogdell, Richard J. (2015) DNA-directed spatial assembly of photosynthetic light-harvesting proteins. Organic & Biomolecular Chemistry, 14 (4). pp. 1359-1362. ISSN 1477-0520

Roe, S., Gunaratnam, M., Spiteri, C., Sharma, Pallavi, Alharthy, R. D., Neidle, S. and Moses, J. E. (2015) Synthesis and biological evaluation of hybrid acridine-HSP90 ligand conjugates as telomerase inhibitors. Organic and Biomolecular Chemistry, 13 . pp. 8500-8504. ISSN 1477-0520

Singh, Ishwar, Heaney, Frances, Batchelor, Caroline and Vyle, Joseph S. (2015) Metal free click chemistry on nucleosides and oligonucleotides. Collection of Czechoslovak Chemical Communications, 10 . p. 451. ISSN 0010-0765

Yamada, Kei, Lear, Martin J., Yamaguchi, Takaya, Yamashita, Shuji, Gridnev, Ilya D., Hayashi, Yujiro and Hirama, Masahiro (2014) Biomimetic total synthesis of cyanosporaside aglycons from a single enediyne precursor through site-selective p-benzyne hydrochlorination. Angewandte Chemie International Edition, 53 (50). pp. 13902-13906. ISSN 1433-7851

Organic synthesis

Fernandez Diaz-Rullo, Fernando, Zamberlan, Francesco, Mewis, Ryan E., Fekete, Marianna, Broche, Lionel, Cheyne, Lesley A., Dall'Angelo, Sergio, Duckett, Simon B., Dawson, Dana and Zanda, Matteo (2017) Synthesis and hyperpolarisation of eNOS substrates for quantification of NO production by 1H NMR spectroscopy. Bioorganic & Medicinal Chemistry, 25 (10). pp. 2730-2742. ISSN 0968-0896

Orlistat

Ngai, Mun H., Yang, Peng-Yu, Liu, Kai, Shen, Yuan, Wenk, Markus R., Yao, Shao Q. and Lear, Martin J. (2010) Click-based synthesis and proteomic profiling of lipstatin analogues. Chemical Communications, 46 (44). p. 8335. ISSN 1359-7345

Yang, Peng-Yu, Liu, Kai, Ngai, Mun Hong, Lear, Martin J., Wenk, Markus R. and Yao, Shao Q. (2010) Activity-based proteome profiling of potential cellular targets of Orlistat - an FDA-approved drug with anti-tumor activities. Journal of the American Chemical Society, 132 (2). pp. 656-666. ISSN 0002-7863

Peptides. PEG

Perinelli, Diego Romano, Campana, Mario, Singh, Ishwar, Vllasaliu, Driton, Doutch, James, Palmieri, Giovanni Filippo and Casettari, Luca (2019) PEGylation affects the self-assembling behaviour of amphiphilic octapeptides. International Journal of Pharmaceutics, 571 (118752). ISSN UNSPECIFIED

Plasmodium falciparum

Ch'ng, J.-H., Kotturi, S. R., Chong, A. G.-L., Lear, Martin J. and Tan, K. S.-W. (2010) A programmed cell death pathway in the malaria parasite Plasmodium falciparum has general features of mammalian apoptosis but is mediated by clan CA cysteine proteases. Cell Death and Disease, 1 (2). e26. ISSN 2041-4889

Self assembly

Perinelli, Diego Romano, Campana, Mario, Singh, Ishwar, Vllasaliu, Driton, Doutch, James, Palmieri, Giovanni Filippo and Casettari, Luca (2019) PEGylation affects the self-assembling behaviour of amphiphilic octapeptides. International Journal of Pharmaceutics, 571 (118752). ISSN UNSPECIFIED

Teixobactin

Parmar, Anish, Iyer, Abhishek, Vincent, Charlotte, Van Lysebetten, Dorien, Prior, Stephen H., Madder, Annemieke, Taylor, Edward J. and Singh, Ishwar (2016) Efficient total syntheses and biological activities of two teixobactin analogues. Chemical Communications, 52 (36). pp. 6060-6063. ISSN 1359-7345

Teixobactins

Fiers, William D., Craighead, Mark and Singh, Ishwar (2017) Teixobactin and its analogues: a new hope in antibiotic discovery. ACS Infectious Diseases, 3 (10). pp. 688-690. ISSN 2373-8227

Telomerase

Roe, S., Gunaratnam, M., Spiteri, C., Sharma, Pallavi, Alharthy, R. D., Neidle, S. and Moses, J. E. (2015) Synthesis and biological evaluation of hybrid acridine-HSP90 ligand conjugates as telomerase inhibitors. Organic and Biomolecular Chemistry, 13 . pp. 8500-8504. ISSN 1477-0520

Tetraols

Ghosh, Shibaji K., Butler, Mark S. and Lear, Martin J. (2012) Synthesis of 2-C-methylerythritols and 2-C-methylthreitols via enantiodivergent Sharpless dihydroxylation of trisubstituted olefins. Tetrahedron Letters, 53 (22). pp. 2706-2708. ISSN 0040-4039

Total synthesis

Lear, Martin (2013) Synthetic ventures into the platensimycins, bielschowskysins, lipstatins, and enediynes. In: Lecture Tour, July 2013, RIKEN, Waseda University, Keio University, Sophia University, Japan.

Lear, Martin (2011) Total synthesis and drug pursuits: laetirobins, lipstatins, platensimycins [ACP Tour, Japan]. In: Asia Core Program Lectureship Tour of Japan, 18-22 Dec 2011, Nagoya, Tokyo, and Tohoku, Japan.

Lear, Martin, Reux, Bastien and Sekar, Karthik (2012) Chemical synthesis, modification and mimicry of the GPI anchor. In: GPI membrane anchors: the much needed link. Bentham Science Publishers Ltd, pp. 64-82. ISBN 9781608051236

Lear, Martin and Yao, Shao Q. (2010) New directions for old drugs. Project Report. National University of Singapore, Singapore.

Ngai, Mun H., Yang, Peng-Yu, Liu, Kai, Shen, Yuan, Wenk, Markus R., Yao, Shao Q. and Lear, Martin J. (2010) Click-based synthesis and proteomic profiling of lipstatin analogues. Chemical Communications, 46 (44). p. 8335. ISSN 1359-7345

Parmar, Anish, Iyer, Abhishek, Vincent, Charlotte, Van Lysebetten, Dorien, Prior, Stephen H., Madder, Annemieke, Taylor, Edward J. and Singh, Ishwar (2016) Efficient total syntheses and biological activities of two teixobactin analogues. Chemical Communications, 52 (36). pp. 6060-6063. ISSN 1359-7345

Simon, Oliver, Reux, Bastien, La Clair, James J. and Lear, Martin J. (2010) Total synthesis confirms laetirobin as a formal Diels-Alder adduct. Chemistry - An Asian Journal, 5 (2). pp. 342-351. ISSN 1861-4728

Yang, Peng-Yu, Liu, Kai, Ngai, Mun Hong, Lear, Martin J., Wenk, Markus R. and Yao, Shao Q. (2010) Activity-based proteome profiling of potential cellular targets of Orlistat - an FDA-approved drug with anti-tumor activities. Journal of the American Chemical Society, 132 (2). pp. 656-666. ISSN 0002-7863

Total synthesis studies

Lear, Martin (2012) Total synthesis and drug pursuits: laetirobins, lipstatins, platensimycins. In: ZiNG Natural Products Conference 2012: Natural Products Synthesis and Biosynthesis, 10 - 13 February 2012, Lanzarote, Spain.

Transannular ring-opening

Kyne, S. H., Miles, J. A. L., Percy, J. M. and Singh, K. (2012) Executing and rationalizing the synthesis of a difluorinated analogue of a ring-expanded calystegine B2. Journal of Organic Chemistry, 77 (2). pp. 991-998. ISSN 0022-3263

Triazole

Roe, S., Gunaratnam, M., Spiteri, C., Sharma, Pallavi, Alharthy, R. D., Neidle, S. and Moses, J. E. (2015) Synthesis and biological evaluation of hybrid acridine-HSP90 ligand conjugates as telomerase inhibitors. Organic and Biomolecular Chemistry, 13 . pp. 8500-8504. ISSN 1477-0520

VRE

Singh, Ishwar and Walden, Benjamin (2018) Simplified teixobactin analogues to target superbugs. Future Medicinal Chemistry, 10 (2). ISSN 1756-8919

Verapamil

Ch'ng, J.-H., Kotturi, S. R., Chong, A. G.-L., Lear, Martin J. and Tan, K. S.-W. (2010) A programmed cell death pathway in the malaria parasite Plasmodium falciparum has general features of mammalian apoptosis but is mediated by clan CA cysteine proteases. Cell Death and Disease, 1 (2). e26. ISSN 2041-4889

anti-tumour agents

Simon, Oliver, Reux, Bastien, La Clair, James J. and Lear, Martin J. (2010) Total synthesis confirms laetirobin as a formal Diels-Alder adduct. Chemistry - An Asian Journal, 5 (2). pp. 342-351. ISSN 1861-4728

antibiotic resistance

Parmar, Anish, Iyer, Abhishek, Vincent, Charlotte, Van Lysebetten, Dorien, Prior, Stephen H., Madder, Annemieke, Taylor, Edward J. and Singh, Ishwar (2016) Efficient total syntheses and biological activities of two teixobactin analogues. Chemical Communications, 52 (36). pp. 6060-6063. ISSN 1359-7345

antibiotics

Fiers, William D., Craighead, Mark and Singh, Ishwar (2017) Teixobactin and its analogues: a new hope in antibiotic discovery. ACS Infectious Diseases, 3 (10). pp. 688-690. ISSN 2373-8227

antiparasitic agents

Yang, Peng-Yu, Wang, Min, Liu, Kai, Ngai, Mun Hong, Sheriff, Omar, Lear, Martin J., Sze, Siu Kwan, He, Cynthia Y. and Yao, Shao Q. (2012) Parasite-based screening and proteome profiling reveal orlistat, an FDA-approved drug, as a potential anti trypanosoma brucei agent. Chemistry - A European Journal, 18 (27). pp. 8403-8413. ISSN 0947-6539

benzenoids

Yamada, Kei, Lear, Martin J., Yamaguchi, Takaya, Yamashita, Shuji, Gridnev, Ilya D., Hayashi, Yujiro and Hirama, Masahiro (2014) Biomimetic total synthesis of cyanosporaside aglycons from a single enediyne precursor through site-selective p-benzyne hydrochlorination. Angewandte Chemie International Edition, 53 (50). pp. 13902-13906. ISSN 1433-7851

bioimaging

Fernandez Diaz-Rullo, Fernando, Zamberlan, Francesco, Mewis, Ryan E., Fekete, Marianna, Broche, Lionel, Cheyne, Lesley A., Dall'Angelo, Sergio, Duckett, Simon B., Dawson, Dana and Zanda, Matteo (2017) Synthesis and hyperpolarisation of eNOS substrates for quantification of NO production by 1H NMR spectroscopy. Bioorganic & Medicinal Chemistry, 25 (10). pp. 2730-2742. ISSN 0968-0896

cell death

Ch'ng, Jun-Hong, Mok, Sachel, Bozdech, Zbynek, Lear, Martin James, Boudhar, Aicha, Russell, Bruce, Nosten, Francois and Tan, Kevin Shyong-Wei (2013) A whole cell pathway screen reveals seven novel chemosensitizers to combat chloroquine resistant malaria. Scientific Reports, 3 (1734). ISSN 2045-2322

click chemistry

Henry, Sarah L., Withers, Jamie M., Singh, Ishwar, Cooper, Jonathan M., Clark, Alasdair W., Burley, Glenn A. and Cogdell, Richard J. (2015) DNA-directed spatial assembly of photosynthetic light-harvesting proteins. Organic & Biomolecular Chemistry, 14 (4). pp. 1359-1362. ISSN 1477-0520

cyclization

Yamada, Kei, Lear, Martin J., Yamaguchi, Takaya, Yamashita, Shuji, Gridnev, Ilya D., Hayashi, Yujiro and Hirama, Masahiro (2014) Biomimetic total synthesis of cyanosporaside aglycons from a single enediyne precursor through site-selective p-benzyne hydrochlorination. Angewandte Chemie International Edition, 53 (50). pp. 13902-13906. ISSN 1433-7851

dimerization

Simon, Oliver, Reux, Bastien, La Clair, James J. and Lear, Martin J. (2010) Total synthesis confirms laetirobin as a formal Diels-Alder adduct. Chemistry - An Asian Journal, 5 (2). pp. 342-351. ISSN 1861-4728

diradicals

Yamada, Kei, Lear, Martin J., Yamaguchi, Takaya, Yamashita, Shuji, Gridnev, Ilya D., Hayashi, Yujiro and Hirama, Masahiro (2014) Biomimetic total synthesis of cyanosporaside aglycons from a single enediyne precursor through site-selective p-benzyne hydrochlorination. Angewandte Chemie International Edition, 53 (50). pp. 13902-13906. ISSN 1433-7851

drug discovery

Yang, Peng-Yu, Wang, Min, Liu, Kai, Ngai, Mun Hong, Sheriff, Omar, Lear, Martin J., Sze, Siu Kwan, He, Cynthia Y. and Yao, Shao Q. (2012) Parasite-based screening and proteome profiling reveal orlistat, an FDA-approved drug, as a potential anti trypanosoma brucei agent. Chemistry - A European Journal, 18 (27). pp. 8403-8413. ISSN 0947-6539

enediynes

Yamada, Kei, Lear, Martin J., Yamaguchi, Takaya, Yamashita, Shuji, Gridnev, Ilya D., Hayashi, Yujiro and Hirama, Masahiro (2014) Biomimetic total synthesis of cyanosporaside aglycons from a single enediyne precursor through site-selective p-benzyne hydrochlorination. Angewandte Chemie International Edition, 53 (50). pp. 13902-13906. ISSN 1433-7851

fluorescent-labelled chloroquine

Ch'ng, J.-H., Kotturi, S. R., Chong, A. G.-L., Lear, Martin J. and Tan, K. S.-W. (2010) A programmed cell death pathway in the malaria parasite Plasmodium falciparum has general features of mammalian apoptosis but is mediated by clan CA cysteine proteases. Cell Death and Disease, 1 (2). e26. ISSN 2041-4889

fluorescent-tagged drug probes

Ch'ng, Jun-Hong, Mok, Sachel, Bozdech, Zbynek, Lear, Martin James, Boudhar, Aicha, Russell, Bruce, Nosten, Francois and Tan, Kevin Shyong-Wei (2013) A whole cell pathway screen reveals seven novel chemosensitizers to combat chloroquine resistant malaria. Scientific Reports, 3 (1734). ISSN 2045-2322

hyperpolarisation

Fernandez Diaz-Rullo, Fernando, Zamberlan, Francesco, Mewis, Ryan E., Fekete, Marianna, Broche, Lionel, Cheyne, Lesley A., Dall'Angelo, Sergio, Duckett, Simon B., Dawson, Dana and Zanda, Matteo (2017) Synthesis and hyperpolarisation of eNOS substrates for quantification of NO production by 1H NMR spectroscopy. Bioorganic & Medicinal Chemistry, 25 (10). pp. 2730-2742. ISSN 0968-0896

malaria

Ch'ng, J.-H., Kotturi, S. R., Chong, A. G.-L., Lear, Martin J. and Tan, K. S.-W. (2010) A programmed cell death pathway in the malaria parasite Plasmodium falciparum has general features of mammalian apoptosis but is mediated by clan CA cysteine proteases. Cell Death and Disease, 1 (2). e26. ISSN 2041-4889

membrane anchor

Hicks, Matthew R., Gill, Andrew C., Bath, Imanpreet K., Rullay, Atvinder K., Sylvester, Ian D., Crout, David H. and Pinheiro, Teresa J. T. (2006) Synthesis and structural characterization of a mimetic membrane-anchored prion protein. FEBS Journal, 273 (6). pp. 1285-1299. ISSN 1742-464X

monochlorination

Yamada, Kei, Lear, Martin J., Yamaguchi, Takaya, Yamashita, Shuji, Gridnev, Ilya D., Hayashi, Yujiro and Hirama, Masahiro (2014) Biomimetic total synthesis of cyanosporaside aglycons from a single enediyne precursor through site-selective p-benzyne hydrochlorination. Angewandte Chemie International Edition, 53 (50). pp. 13902-13906. ISSN 1433-7851

orlistat

Yang, Peng-Yu, Wang, Min, Liu, Kai, Ngai, Mun Hong, Sheriff, Omar, Lear, Martin J., Sze, Siu Kwan, He, Cynthia Y. and Yao, Shao Q. (2012) Parasite-based screening and proteome profiling reveal orlistat, an FDA-approved drug, as a potential anti trypanosoma brucei agent. Chemistry - A European Journal, 18 (27). pp. 8403-8413. ISSN 0947-6539

parasitology

Ch'ng, Jun-Hong, Mok, Sachel, Bozdech, Zbynek, Lear, Martin James, Boudhar, Aicha, Russell, Bruce, Nosten, Francois and Tan, Kevin Shyong-Wei (2013) A whole cell pathway screen reveals seven novel chemosensitizers to combat chloroquine resistant malaria. Scientific Reports, 3 (1734). ISSN 2045-2322

phenotypic screening

Ch'ng, Jun-Hong, Mok, Sachel, Bozdech, Zbynek, Lear, Martin James, Boudhar, Aicha, Russell, Bruce, Nosten, Francois and Tan, Kevin Shyong-Wei (2013) A whole cell pathway screen reveals seven novel chemosensitizers to combat chloroquine resistant malaria. Scientific Reports, 3 (1734). ISSN 2045-2322

prion

Hicks, Matthew R., Gill, Andrew C., Bath, Imanpreet K., Rullay, Atvinder K., Sylvester, Ian D., Crout, David H. and Pinheiro, Teresa J. T. (2006) Synthesis and structural characterization of a mimetic membrane-anchored prion protein. FEBS Journal, 273 (6). pp. 1285-1299. ISSN 1742-464X

programmed cell death

Ch'ng, J.-H., Kotturi, S. R., Chong, A. G.-L., Lear, Martin J. and Tan, K. S.-W. (2010) A programmed cell death pathway in the malaria parasite Plasmodium falciparum has general features of mammalian apoptosis but is mediated by clan CA cysteine proteases. Cell Death and Disease, 1 (2). e26. ISSN 2041-4889

proteomics

Yang, Peng-Yu, Wang, Min, Liu, Kai, Ngai, Mun Hong, Sheriff, Omar, Lear, Martin J., Sze, Siu Kwan, He, Cynthia Y. and Yao, Shao Q. (2012) Parasite-based screening and proteome profiling reveal orlistat, an FDA-approved drug, as a potential anti trypanosoma brucei agent. Chemistry - A European Journal, 18 (27). pp. 8403-8413. ISSN 0947-6539

trypanosomiasis

Yang, Peng-Yu, Wang, Min, Liu, Kai, Ngai, Mun Hong, Sheriff, Omar, Lear, Martin J., Sze, Siu Kwan, He, Cynthia Y. and Yao, Shao Q. (2012) Parasite-based screening and proteome profiling reveal orlistat, an FDA-approved drug, as a potential anti trypanosoma brucei agent. Chemistry - A European Journal, 18 (27). pp. 8403-8413. ISSN 0947-6539

x-ray crystallography

Caserta, Giorgio, Pecqueur, Ludovic, Adamska-Venkatesh, Agnieszka, Papini, Cecilia, Roy, Souvik, Artero, Vincent, Atta, Mohamed, Reijerse, Edward, Lubitz, Wolfgang and Fontecave, Marc (2017) Structural and functional characterization of the hydrogenase-maturation HydF protein. Nature Chemical Biology, 13 (7). pp. 779-784. ISSN 1552-4450

This list was generated on Sat May 30 00:17:03 2020 BST.