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'click' ligand 1 2-Deoxy sugars 3-dipolar addition 3-dipolar cycloaddition ?-Stacking interaction Ab initio and DFT calculations Ab initio structural calculations Acetone cyano hydrin Acridine-HSP90 Acyl ketene Aldol reaction Alkenyl nitrile Amidation Amide synthesis Amino acids Anitmalarial agents Anitproliferative activity Anthraquinonecarboxylic acid Anti-tumor activities Antibody labelling Antiproliferative activity Aryl halide Asymmetric catalysis Asymmetric resolution Asymmetric synthesis Bead microarray Benzisoxazole Bezisoxazole Bielschowskysin Binding affinity screening Bio-target identification Bio-targeting Biology Biomedicine Biomimetic Synthesis Biomimetic synthesis Biomimicry Biomolecular identification Biosynthesis Biotarget identification Biotechnology Bismuth Brewster angle microscopy Brewster angle reflectometry Bulgecinine C-terminal fragment CCG Cembranes Chemical characterisation Chemical proteomics Chemical reagent Chemistry Chirality Chitinophaga Click Chemistry Click reaction Click-chemistry Computational chemistry Conjugate reduction Conjugated Polymer Convergent synthetic strategy Coupling reagents Crystal engineering Cyanamide Cyanation Cycloaddition Cycloalkenes Cycloaromatization DMSO solvate DNA cleavage DNA sequence DNA-binding polyamides Dehydrofluorination/zincation Density functional theory Density functional theory calculations Deoxy sugars Detection of binding events Diels-Alder Dimer Diterpenes Donor-?-Acceptor Drug discovery Drug labelling Drug off-targets Drug resistance Dye-Sensitized Solar Cells Dye-sensitized Solar Cells Electrochemistry Electrocyclisation Electrocycllisation Enantiodivergent Epoxidation reaction Erythrulose Falcitidin Fatty acid synthase Fluorescence Fluorescent immuno-affinity label Fluorescent labels Fluorescent sensing Fluorescent-labeled probes Free radical carbonylation Free radical chemistry Friedel-Crafts Furanocembranoid G-quadruplex Gas chromatography Globalisation Glycobiology Glycolipids Glycosylation Grignard addition Hairpin pyrrole-imidazole polyamides Hole Transporter Homogenous catalysis Homolytic substitution Hybrid solar cell Hydrazone Hydrogen Bonding Imine Immobilisation chemistry Immuno-affinity screening Inositol Interfacial modification Intermolecular interactions Intermolecular radical addition Intramolecular Intramolecular cyclisation Iron Isotope labelling Kinetics Kingianin A Knoevenagel reaction Lactate dehydrogenase Laser ablation Lead discovery MIRC Macrocyclisation Malaria Malaria detection Maleimide reagents Mechanism Merocyanine Merocyanines Metal-free organic dye Metathesis reactions Methodology Mevalonate Michael addition Mode-of-action Molecular Conformation N-terminal fragment NMR spectroscopy NMR study Natural Product Natural Products Natural enediynes Natural product Natural products Negishi coupling Nitrile Oxide Odor activity value Olfractometry Organic Dye Organic Sensitizer Organic Sensitizers Organic methods Organic synthesis Organic vapor sorption Organocatalysis Organocatalyst Organohalogens Orlistat Oxadiazol-5-imine Oxazoles P3HT Palladium catalysis Peptide synthesis Peptides Photo-switches Photochemistry Plasmodium Poly(3-hexylthiophene) Polyketide Polypropionate Polythiophene Protecting groups Protein tyrosine kinases QMB measurement Radical Cation Radical cyclization Radical reaction Reaction kinetics Reduction SNAP-tag technology Selenium Self-assembled monolayers Sensitized Solar Cells Singapore Smart optical linkers Solid phase Solid-State Sonogashira Spiropyran Spiropyran monolayers Spiropyrans Stereoisomer synthesis Stereoselective Stereoselective glycosylation Structure-Activity Relationship Sulfinamides Sulfinates Telomerase Tetraols Tetrapeptide Total synthesis Total synthesis studies Transannular ring-opening Triazole Trifluormethyl Triphenylamine Tyrophostins Tyrphostins Virtual screening X-ray diffraction X-ray structure X-ray studies X-ray study Zirconium alkyne silane amidation amide amino acid anti-tumour agents antimalarial antiparasitic agents asymmetric induction azide benzenoids benzothiophen benzyne bioassay bioisotere biomimetic synthesis bismuth bisphenol bmjdoi bmjgoldcheck calixarene caprolactam catenanes; interlocked molecules; links; supramolecular chemistry; template synthesis chemical proteomics chemisorption chlorinated organics click chemistry computational modeling conformational analysis conformational studies conjugate reduction conjugation cyanoacetic acid cyclization cyclophane cyclopropane dimerization diradicals drug discovery electrocyclisation enediynes excimer falcipain falcitidin fluorescence fluorescent dye fluorescent probes gamma pyrone glycolysis halogen bonding hazardous waste heteroaromatic compound heterocycles homolytic substitution host-guest hydrogen storage iminium inclusion compound indole alkaloid iodination iodine isometricity comparison isostructurality kinetics malaria metal-organic frameworks microparticles mitralactonine mixed-linker molecular overlay calculation mollusc monochlorination morphotropism myxobacteria oapaid organic synthesis organocatalysis orlistat p-Benzynes peptide formation phochemical photochemical polypropionate proteomics pyrene radical reagentless assay reductive destruction rhodanine-3-acetic acid ring closing metathesis self assembly self-defence sensor active material solid state solvent inclusion synthon tetrapeptide tetraphenylethene thio-acid total synthesis tridachiahydropyrone trimesic acid homologue trypanosomiasis umpolung water wheel-and-axle host
Number of items at this level: 501.

'click' ligand

Cousins, Alex R. O. and Ritson, Dougal and Sharma, Pallavi and Stevens, Malcolm F. G. and Moses, John E. and Searle, Mark S. (2014) Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences. Chemical Communications, 50 . pp. 15202-15205. ISSN 1359-7345

1

Bhat, Shreesha V. and Robinson, David and Moses, John E. and Sharma, Pallavi (2016) Synthesis of oxadiazol-5-imines via the cyclizative capture of in situ generated cyanamide ions and nitrile oxides. Organic Letters, 18 (5). pp. 1100-1103. ISSN 1523-7060

Spiteri, Christian and Mason, Christopher and Zhang, Fengzhi and Ritson, Dougal J. and Sharma, Pallavi and Keeling, Steve and Moses, John E. (2010) An efficient entry to 1,2-benzisoxazoles via 1,3-dipolar cycloaddition of in situ generated nitrile oxides and benzyne. Organic and Biomolecular Chemistry Articles, 8 (11). pp. 2537-2542. ISSN 1477-0520

Spiteri, Christian and Sharma, Pallavi and Zhang, Fengzhi and Macdonald, Simon J. F. and Keeling, Steve and Moses, John E. (2010) An improved synthesis of 1,2-benzisoxazoles: TBAF mediated 1,3-dipolar cycloaddition of nitrile oxides and benzyne. Chemical Communications, 46 (8). pp. 1272-1274. ISSN 1359-7345

2-Deoxy sugars

Lear, Martin J. and Hirama, Masahiro (1999) Convenient route to derivatives of the 2-deoxysugar subunits of the kedarcidin chromophore: L-mycarose and L-kedarosamine. Tetrahedron Letters, 40 (26). pp. 4897-4900. ISSN 0040-4039

Lear, Martin J. and Yoshimura, Fumihiko and Hirama, Masahiro (2001) A direct and efficient α-selective glycosylation protocol for the kedarcidin sugar, L-mycarose: AgPF6 as a remarkable activator of 2-deoxythioglycosides. Angewandte Chemie International Edition, 40 (5). pp. 946-949. ISSN 1433-7851

3-dipolar addition

Spiteri, Christian and Sharma, Pallavi and Zhang, Fengzhi and Macdonald, Simon J. F. and Keeling, Steve and Moses, John E. (2010) An improved synthesis of 1,2-benzisoxazoles: TBAF mediated 1,3-dipolar cycloaddition of nitrile oxides and benzyne. Chemical Communications, 46 (8). pp. 1272-1274. ISSN 1359-7345

3-dipolar cycloaddition

Bhat, Shreesha V. and Robinson, David and Moses, John E. and Sharma, Pallavi (2016) Synthesis of oxadiazol-5-imines via the cyclizative capture of in situ generated cyanamide ions and nitrile oxides. Organic Letters, 18 (5). pp. 1100-1103. ISSN 1523-7060

Spiteri, Christian and Mason, Christopher and Zhang, Fengzhi and Ritson, Dougal J. and Sharma, Pallavi and Keeling, Steve and Moses, John E. (2010) An efficient entry to 1,2-benzisoxazoles via 1,3-dipolar cycloaddition of in situ generated nitrile oxides and benzyne. Organic and Biomolecular Chemistry Articles, 8 (11). pp. 2537-2542. ISSN 1477-0520

?-Stacking interaction

Gruber, Tobias and Helas, Stefanie F. and Seichter, Wilhelm and Weber, Edwin (2010) X-ray crystal structures of two solvent complexes involving positionally isomeric 9,10-anthraquinonecarboxylic acids and DMSO. Structural Chemistry, 21 (5). pp. 1079-1083. ISSN 1040-0400

Ab initio and DFT calculations

Kyne, Sara and Schiesser, C. H. (2009) Ab initio studies of carbonyl radical additions to hydrazone systems. Australian Journal of Chemistry, 62 (7). pp. 728-733. ISSN 0004-9425

Ab initio structural calculations

Kyne, S. H. and Schiesser, C. H. and Matsubara, H. (2008) Multiorbital interactions during acyl radical addition reactions involving imines and electron-rich olefins. Journal of Organic Chemistry, 73 (2). pp. 427-434. ISSN 0022-3263

Kyne, S. H. and Schiesser, C. H. and Matsubara, H. (2011) An ab initio and DFT study of radical addition reactions of imidoyl and thioyl radicals to methanimine. Organic and Biomolecular Chemistry, 9 (9). pp. 3217-3224. ISSN 1477-0520

Acetone cyano hydrin

Powell, Kimberley J. and Han, Li-Chen and Sharma, Pallavi and Moses, John E. (2014) Chemoselective palladium-catalyzed cyanation of alkenyl halides. Organic Letters, 16 (8). pp. 2158-2161. ISSN 1523-7060

Acridine-HSP90

Roe, S. and Gunaratnam, M. and Spiteri, C. and Sharma, Pallavi and Alharthy, R. D. and Neidle, S. and Moses, J. E. (2015) Synthesis and biological evaluation of hybrid acridine-HSP90 ligand conjugates as telomerase inhibitors. Organic and Biomolecular Chemistry, 13 . pp. 8500-8504. ISSN 1477-0520

Acyl ketene

Yang, Eugene G. and Sekar, Karthik and Lear, Martin J. (2013) A macrolactonisation approach to the cembrane carbocycle of bielschowskysin. Tetrahedron Letters, 54 (33). pp. 4406-4408. ISSN 0040-4039

Aldol reaction

Liu, Xiang Hui and Song, Hong Yan and Ma, Xiao Hua and Lear, Martin J. and Chen, Yu Zong (2010) Virtual screening prediction of new potential organocatalysts for direct aldol reactions. Journal of Molecular Catalysis A: Chemical, 319 (1-2). pp. 114-118. ISSN 1381-1169

Alkenyl nitrile

Powell, Kimberley J. and Han, Li-Chen and Sharma, Pallavi and Moses, John E. (2014) Chemoselective palladium-catalyzed cyanation of alkenyl halides. Organic Letters, 16 (8). pp. 2158-2161. ISSN 1523-7060

Amidation

Li, Jing and Lear, Martin and Kwon, Eunsang and Hayashi, Yujiro (2016) Mechanism of oxidative amidation of nitroalkanes with oxygen and amine nucleophiles using electrophilic iodine. Chemistry - A European Journal, 22 (16). pp. 5538-5542. ISSN 0947-6539

Amide synthesis

Li, Jing and Lear, Martin and Hayashi, Yujiro (2016) Sterically demanding oxidative amidation of alpha-substituted malononitriles with amines using O2. Angewandte Chemie International Edition, 55 (31). pp. 9060-9064. ISSN 1433-7851

Amino acids

Ghosh, Shibaji K. and Somanadhan, Brinda and Tan, Kevin S.-W. and Butler, Mark S. and Lear, Martin J. (2012) Absolute configuration and total synthesis of a novel antimalarial lipopeptide by the de novo preparation of chiral nonproteinogenic amino acids. Organic Letters, 14 (6). pp. 1560-1563. ISSN 1523-7060

Anitmalarial agents

Kotturi, Santosh R. and Somanadhan, Brinda and Ch’ng, Jun-Hong and Tan, Kevin S.-W. and Butler, Mark S. and Lear, Martin J. (2014) Diverted total synthesis of falcitidin acyl tetrapeptides as new antimalarial leads. Tetrahedron Letters, 55 (11). pp. 1949-1951. ISSN 0040-4039

Anitproliferative activity

Brunton, V. G. and Lear, M. and Robins, D. J. and Williamson, S. and Workman, P. (1994) Synthesis and antiproliferative activity of tyrphostins containing heteroaromatic moieties. Anti-Cancer Drug Design, 9 (4). pp. 291-309. ISSN 0266-9536

Anthraquinonecarboxylic acid

Gruber, Tobias and Helas, Stefanie F. and Seichter, Wilhelm and Weber, Edwin (2010) X-ray crystal structures of two solvent complexes involving positionally isomeric 9,10-anthraquinonecarboxylic acids and DMSO. Structural Chemistry, 21 (5). pp. 1079-1083. ISSN 1040-0400

Anti-tumor activities

Yang, Peng-Yu and Liu, Kai and Ngai, Mun Hong and Lear, Martin J. and Wenk, Markus R. and Yao, Shao Q. (2010) Activity-based proteome profiling of potential cellular targets of Orlistat - an FDA-approved drug with anti-tumor activities. Journal of the American Chemical Society, 132 (2). pp. 656-666. ISSN 0002-7863

Antibody labelling

Song, Hong Y. and Ngai, Mun H. and Song, Zhen Y. and MacAry, Paul A. and Hobley, Jonathan and Lear, Martin J. (2009) Practical synthesis of maleimides and coumarin-linked probes for protein and antibody labelling via reduction of native disulfides. Organic & Biomolecular Chemistry, 7 (17). pp. 3400-3406. ISSN 1477-0520

Antiproliferative activity

Brunton, V. G. and Lear, M. and McKeown, P. and Robins, D. J. and Workman, P. (1996) Synthesis and antiproliferative activity of tyrphostins containing quinoline moieties. Anti-Cancer Drug Design, 11 (6). pp. 463-483. ISSN 0266-9536

Aryl halide

Kyne, Sara H. and Percy, Jonathon M. and Pullin, Robert D. C. and Redmond, Joanna M. and Wilson, Peter G. (2011) One-pot near-ambient temperature syntheses of aryl(difluoroenol) derivatives from trifluoroethanol. Organic and Biomolecular Chemistry, 9 (24). pp. 8328-8339. ISSN 14770520

Asymmetric catalysis

Liu, Xiang Hui and Song, Hong Yan and Ma, Xiao Hua and Lear, Martin J. and Chen, Yu Zong (2010) Virtual screening prediction of new potential organocatalysts for direct aldol reactions. Journal of Molecular Catalysis A: Chemical, 319 (1-2). pp. 114-118. ISSN 1381-1169

Asymmetric resolution

Ali, Asif and Wenk, Markus R. and Lear, Martin J. (2009) Total synthesis of a fully lipidated form of phosphatidyl-myo-inositol dimannoside (PIM-2) of Mycobacterium tuberculosis. Tetrahedron Letters, 50 (40). pp. 5664-5666. ISSN 0040-4039

Asymmetric synthesis

Hayashi, Yujiro and Shomura, Hiroki and Xu, Qianqian and Lear, Martin and Sato, Itaru (2015) Asymmetric aldol reaction of α,α-disubstituted acetaldehydes catalyzed by Ddphenylprolinol silyl ether for the construction of quaternary stereogenic centers. European Journal of Organic Chemistry, 20 . pp. 4316-4319. ISSN 1434-193X

Bead microarray

National University of Singapore (2013) A microparticle assembly. WO2013176625 A1.

Benzisoxazole

Spiteri, Christian and Mason, Christopher and Zhang, Fengzhi and Ritson, Dougal J. and Sharma, Pallavi and Keeling, Steve and Moses, John E. (2010) An efficient entry to 1,2-benzisoxazoles via 1,3-dipolar cycloaddition of in situ generated nitrile oxides and benzyne. Organic and Biomolecular Chemistry Articles, 8 (11). pp. 2537-2542. ISSN 1477-0520

Bezisoxazole

Spiteri, Christian and Sharma, Pallavi and Zhang, Fengzhi and Macdonald, Simon J. F. and Keeling, Steve and Moses, John E. (2010) An improved synthesis of 1,2-benzisoxazoles: TBAF mediated 1,3-dipolar cycloaddition of nitrile oxides and benzyne. Chemical Communications, 46 (8). pp. 1272-1274. ISSN 1359-7345

Bielschowskysin

Miao, Ru and Gramani, Subramanian G. and Lear, Martin J. (2009) Stereocontrolled entry to the tricyclo[3.3.0]oxoheptane core of bielschowskysin by a [2+2] cycloaddition of an allene-butenolide. Tetrahedron Letters, 50 (15). pp. 1731-1733. ISSN ISSN

Yang, Eugene G. and Sekar, Karthik and Lear, Martin J. (2013) A macrolactonisation approach to the cembrane carbocycle of bielschowskysin. Tetrahedron Letters, 54 (33). pp. 4406-4408. ISSN 0040-4039

Binding affinity screening

Rodríguez, Abimael D. and Lear, Martin J. and La Clair, James J. (2008) Identification of the binding of sceptrin to MreB via a bidirectional affinity protocol. Journal of the American Chemical Society, 130 (23). pp. 7256-7258. ISSN 0002-7863

Bio-target identification

Lear, Martin (2011) Total synthesis and drug pursuits: laetirobins, lipstatins, platensimycins [ACP Tour, Japan]. In: Asia Core Program Lectureship Tour of Japan, 18-22 Dec 2011, Nagoya, Tokyo, and Tohoku, Japan.

Bio-targeting

Lear, Martin (2010) Exploring the glycolipidome via chemical mimicry. In: EMBO Conference Series: Chemical Biology 2010, 22 - 25 Sep 2010, EMBL Heidelberg, Germany.

Biology

Lear, Martin J. and Salmons, Brian and Gunzburg, Walter H. and Dangerfield, John A. (2009) Singapore R&D and globetrotting. Biotechnology Journal, 4 (2). pp. 179-185. ISSN ISSN

Biomedicine

Lear, Martin J. and Salmons, Brian and Gunzburg, Walter H. and Dangerfield, John A. (2009) Singapore R&D and globetrotting. Biotechnology Journal, 4 (2). pp. 179-185. ISSN ISSN

Biomimetic Synthesis

Lear, Martin (2010) Exploring the glycolipidome via chemical mimicry. In: EMBO Conference Series: Chemical Biology 2010, 22 - 25 Sep 2010, EMBL Heidelberg, Germany.

Lear, Martin and Hirai, Keiichiro and Yamada, Kei and Takahashi, Ryo and Hirama, Masahiro (2014) Total synthesis and biomimetic studies of nine-membered enediynes. In: CRC International Symposium: Synthesis and Applications of Functional Molecules and Materials Utilizing Biomolecules as a Motif, September 30, 2014, Catalytic Research Center, Hokkaido University, Japan.

Sharma, Pallavi (2016) Biomimetic approaches towards the synthesis of complex dimeric natural products. Current Pharmaceutical Design . ISSN 1381-6128

Sharma, Pallavi and Powell, Kimberley J. and Burnley, James and Moses, John E. and Awaad, Amani S. (2011) Total synthesis of polypropionate derived y-pyrone natural products. Synthesis, 18 . pp. 2865-2892. ISSN 0039-7881

Sharma, Pallavi and Ritson, Dougal J. and Burnley, James and Moses, John E. (2011) A synthetic approach to Kingianin A based upon biosynthetic speculation. Chemical Communications, 47 (38). pp. 10605-10607. ISSN 1359-7345

Biomimetic synthesis

Burnley, James and Ralph, Michael and Sharma, Pallavi and Moses, John E. (2011) Biomimetic electrocyclisation reactions towards polyketide-derived natural products. In: Biomimetic Organic Synthesis. Wiley-VCH, Weinheim. ISBN 9783527325801, 9783527634606

Simon, Oliver and Reux, Bastien and La Clair, James J. and Lear, Martin J. (2010) Total synthesis confirms laetirobin as a formal Diels-Alder adduct. Chemistry - An Asian Journal, 5 (2). pp. 342-351. ISSN 1861-4728

Biomimicry

Lear, Martin (2010) Exploring the glycolipidome via chemical mimicry. In: EMBO Conference Series: Chemical Biology 2010, 22 - 25 Sep 2010, EMBL Heidelberg, Germany.

Lear, Martin and Reux, Bastien and Sekar, Karthik (2012) Chemical synthesis, modification and mimicry of the GPI anchor. In: GPI membrane anchors: the much needed link. Bentham Science Publishers Ltd, pp. 64-82. ISBN 9781608051236

Biomolecular identification

Lear, Martin (2010) Exploring the glycolipidome via chemical mimicry. In: EMBO Conference Series: Chemical Biology 2010, 22 - 25 Sep 2010, EMBL Heidelberg, Germany.

Biosynthesis

Pasari, Sandip and Ismail, Shareef M. and Wenk, Markus R. and Lear, Martin (2015) Preparation of azide biosynthetic surrogates of myo-Inositol. Tetrahedron Letters, 56 (20). pp. 2597-2601. ISSN 0040-4039

Biotarget identification

Rodríguez, Abimael D. and Lear, Martin J. and La Clair, James J. (2008) Identification of the binding of sceptrin to MreB via a bidirectional affinity protocol. Journal of the American Chemical Society, 130 (23). pp. 7256-7258. ISSN 0002-7863

Biotechnology

Lear, Martin J. and Salmons, Brian and Gunzburg, Walter H. and Dangerfield, John A. (2009) Singapore R&D and globetrotting. Biotechnology Journal, 4 (2). pp. 179-185. ISSN ISSN

Bismuth

Eey, Stanley T.-C. and Lear, Martin J. (2010) A bismuth(III)-catalyzed Friedel−Crafts cyclization and stereocontrolled organocatalytic approach to (−)-platensimycin. Organic Letters, 12 (23). pp. 5510-5513. ISSN 1523-7060

Brewster angle microscopy

Gorelik, Sergey and Hongyan, Song and Lear, Martin J. and Hobley, Jonathan (2010) Transient Brewster angle reflectometry of spiropyran monolayers. Photochemical and Photobiological Sciences, 9 (2). pp. 141-151. ISSN 1474-905X

Li, Y. and Song, H. Y. and Lear, M. J. and Gorelik, S. and Tomczak, N. and Hobley, J. (2008) Optical detection of photo-activated protein adsorption using Brewster angle microscopy. In: PhotonicsGlobal@Singapore, 2008. IPGC 2008, 8-11 Dec 2008, Singapore.

Brewster angle reflectometry

Siebenhofer, Bernhard and Gorelik, Sergey and Lear, Martin J. and Song, Hong Yan and Nowak, Christoph and Hobley, Jonathan (2013) Transient absorption spectroscopy on spiropyran monolayers using nanosecond pump–probe Brewster angle reflectometry. Photochemical & Photobiological Sciences, 12 (5). pp. 848-853. ISSN 1474-905X

Bulgecinine

Chavan, Subhash P and Praveen, Cherukupally and Sharma, Pallavi and Kalkote, U. R. (2005) An efficient stereoselective synthesis of (2S,4S,5R)-(-)- and (2R,4R,5S)-(+)-bulgecinine. Tetrahedron Letters, 46 (3). pp. 439-441. ISSN 0040-4039

C-terminal fragment

Fallows, Andrew J. and Singh, Ishwar and Dondi, Ruggero and Cullis, Paul M. and Burley, Glenn A. (2014) Highly efficient synthesis of DNA-binding polyamides using a convergent fragment-based approach. Organic Letters, 16 (17). pp. 4654-4657. ISSN 1523-7060

CCG

Chavan, Subhash P. and Sharma, Pallavi and Sivappa, Rasapalli and Bhadbhade, Mohan B. and Gonnade, Rajesh G. and Kalkote, Uttam R. (2003) Enantioselective synthesis of L-CCG-I. Journal of the American Chemical Society, 68 (17). pp. 6871-6819. ISSN 0002-7863

Cembranes

Miao, Ru and Gramani, Subramanian G. and Lear, Martin J. (2009) Stereocontrolled entry to the tricyclo[3.3.0]oxoheptane core of bielschowskysin by a [2+2] cycloaddition of an allene-butenolide. Tetrahedron Letters, 50 (15). pp. 1731-1733. ISSN ISSN

Chemical characterisation

Lear, Martin J. and Simon, Oliver and Foley, Timothy L. and Burkart, Michael D. and Baiga, Thomas J. and Noel, Joseph P. and DiPasquale, Antonio G. and Rheingold, Arnold L. and La Clair, James J. (2009) Laetirobin from the parasitic growth of Laetiporus sulphurous on Robinia pseudoacacia. Journal of Natural Products, 72 (11). pp. 1980-1987. ISSN 0163-3864

Chemical proteomics

Lear, Martin and Yao, Shao Q. (2010) New directions for old drugs. Project Report. National University of Singapore, Singapore.

Ngai, Mun H. and Yang, Peng-Yu and Liu, Kai and Shen, Yuan and Wenk, Markus R. and Yao, Shao Q. and Lear, Martin J. (2010) Click-based synthesis and proteomic profiling of lipstatin analogues. Chemical Communications, 46 (44). p. 8335. ISSN 1359-7345

Yang, Peng-Yu and Liu, Kai and Ngai, Mun Hong and Lear, Martin J. and Wenk, Markus R. and Yao, Shao Q. (2010) Activity-based proteome profiling of potential cellular targets of Orlistat - an FDA-approved drug with anti-tumor activities. Journal of the American Chemical Society, 132 (2). pp. 656-666. ISSN 0002-7863

Chemical reagent

Kotturi, Santosh R. and Tan, Jason S. and Lear, Martin J. (2009) A mild method for the protection of alcohols using a para-methoxybenzylthio tetrazole (PMB-ST) under dual acid–base activation. Tetrahedron Letters, 50 (37). pp. 5267-5269. ISSN 0040-4039

Chemistry

Lear, Martin J. and Salmons, Brian and Gunzburg, Walter H. and Dangerfield, John A. (2009) Singapore R&D and globetrotting. Biotechnology Journal, 4 (2). pp. 179-185. ISSN ISSN

Chirality

Gruber, Tobias and Gruner, Margit and Fischer, Conrad and Seichter, Wilhelm and Bombicz, Petra and Weber, Edwin (2010) Conformational behaviour and first crystal structures of a calix[4]arene featuring a laterally positioned carboxylic acid function in unsolvated and solvent-complexed forms. New Journal of Chemistry, 34 (2). p. 250. ISSN 1144-0546

Chitinophaga

Somanadhan, Brinda and Kotturi, Santosh R. and Yan Leong, Chung and Glover, Robert P. and Huang, Yicun and Flotow, Horst and Buss, Antony D. and Lear, Martin J. and Butler, Mark S. (2013) Isolation and synthesis of falcitidin, a novel myxobacterial-derived acyltetrapeptide with activity against the malaria target falcipain-2. The Journal of Antibiotics, 66 (5). pp. 259-264. ISSN 0021-8820

Click Chemistry

Roe, S. and Gunaratnam, M. and Spiteri, C. and Sharma, Pallavi and Alharthy, R. D. and Neidle, S. and Moses, J. E. (2015) Synthesis and biological evaluation of hybrid acridine-HSP90 ligand conjugates as telomerase inhibitors. Organic and Biomolecular Chemistry, 13 . pp. 8500-8504. ISSN 1477-0520

Click reaction

Sharma, Pallavi and Moses, John E. (2010) Ethynyldiisopropylsilyl: a new alkynylsilane protecting group and click linker. Org. Lett., 12 (12). pp. 2860-2863. ISSN 1523-7060

Click-chemistry

Moorhouse, Adam D. and Spiteri, Christian and Sharma, Pallavi and Zloh, Mire and Moses, John E. (2011) Targeting glycolysis: a fragment based approach towards bifunctional inhibitors of hLDH-5. Chemical Communications, 47 (1). pp. 230-232. ISSN 1359-7345

Computational chemistry

MacDougall, P .E. and Aitken, H. M. and Scammells, P. J. and Kavanagh, Y. and Kyne, S. H. and Schiesser, C. H. (2012) 7-Selenabicyclo2.2.1heptane. Chemical Communications, 48 (73). pp. 9126-9128. ISSN 1359-7345

Conjugate reduction

Eey, Stanley T.-C. and Lear, Martin J. (2010) A bismuth(III)-catalyzed Friedel−Crafts cyclization and stereocontrolled organocatalytic approach to (−)-platensimycin. Organic Letters, 12 (23). pp. 5510-5513. ISSN 1523-7060

Conjugated Polymer

Zhang, Wei and Fang, Zhen and Su, Mingjuan and Saeys, Mark and Liu, Bin (2009) A triphenylamine-based conjugated polymer with donor-π-acceptor architecture as organic sensitizer for dye-sensitized solar cells. Macromolecular Rapid Communications, 30 (18). pp. 1533-1537. ISSN 1022-1336

Convergent synthetic strategy

Fallows, Andrew J. and Singh, Ishwar and Dondi, Ruggero and Cullis, Paul M. and Burley, Glenn A. (2014) Highly efficient synthesis of DNA-binding polyamides using a convergent fragment-based approach. Organic Letters, 16 (17). pp. 4654-4657. ISSN 1523-7060

Coupling reagents

Fallows, Andrew J. and Singh, Ishwar and Dondi, Ruggero and Cullis, Paul M. and Burley, Glenn A. (2014) Highly efficient synthesis of DNA-binding polyamides using a convergent fragment-based approach. Organic Letters, 16 (17). pp. 4654-4657. ISSN 1523-7060

Crystal engineering

Fischer, Conrad and Gruber, Tobias and Eissmann, Diana and Seichter, Wilhelm and Weber, Edwin (2011) Unusual behavior of a calix[4]arene featuring the coexistence of basic cone and 1,2-alternate conformations in a solvated crystal. Crystal Growth & Design, 11 (5). pp. 1989-1994. ISSN 1528-7483

Fischer, Conrad and Gruber, Tobias and Seichter, Wilhelm and Schindler, Diana and Weber, Edwin (2008) 5,11,17,23-Tetra-tert-butyl-25,26,27,28-tetramethoxycalix[4]arene dichloromethane hemisolvate. Acta Crystallographica Section E: Structure Reports Online, 64 (4). o673-o673. ISSN 0365-110X

Fischer, Conrad and Gruber, Tobias and Seichter, Wilhelm and Weber, Edwin (2007) 5,11,17,23-Tetra-tert-butyl-25,26,27,28-tetramethoxycalix[4]arene tetrahydrofuran solvate. Acta Crystallographica Section E: Structure Reports Online, 63 (12). o4572-o4573. ISSN 0365-110X

Fischer, Conrad and Gruber, Tobias and Seichter, Wilhelm and Weber, Edwin and Ibragimov, Bakhtiyar T. (2008) N-Cyclododecyl-5-(dimethylamino)naphthalene-1-sulfonamide. Acta Crystallographica Section E: Structure Reports Online, 64 (7). o1204. ISSN 0365-110X

Gruber, Tobias and Eissmann, Frank and Seichter, Wilhelm and Weber, Edwin (2010) 25-Allyloxy-5,11,17,23-tetra-tert-butyl-26,27,28-trihydroxycalix[4]arene chloroform disolvate. Acta Crystallographica Section C: Crystal Structure Communications, 66 (7). o334-o336. ISSN 0365-110X

Gruber, Tobias and Eissmann, Frank and Weber, Edwin and Schüürmann, Gerrit (2011) 1-Methyl-4-(4-nitrobenzoyl)pyridinium perchlorate. Acta Crystallographica Section E: Structure Reports Online, 67 (9). o2542-o2543. ISSN 0365-110X

Gruber, Tobias and Schofield, Christopher J. and Thompson, Amber L. (2012) 3-Methoxy-3-oxopropanaminium chloride. Acta Crystallographica Section E: Structure Reports Online, 68 (3). o595. ISSN 0365-110X

Gruber, Tobias and Schofield, Christopher J. and Thompson, Amber L. (2012) Methyl 6-amino-6-oxohexanoate. Acta Crystallographica Section E: Structure Reports Online, 68 (3). o593-o594. ISSN 0365-110X

Gruber, Tobias and Seichter, Wilhelm and Weber, Edwin (2010) 1-(Hydroxymethyl)pyrene. Acta Crystallographica Section E: Structure Reports Online, 66 (2). o443. ISSN 0365-110X

Gruber, Tobias and Seichter, Wilhelm and Weber, Edwin (2007) Crystal structure of 25,26,27,28-tetrabenzyloxy-5,11,17,23-tert-butylcalix- [4]arene, C72H80O4. Zeitschrift für Kristallographie - New Crystal Structures, 222 (3). pp. 222-224. ISSN 1433-7266

Münch, Alexander S. and Katzsch, Felix and Gruber, Tobias and Mertens, Florian O.R.L. (2014) Spectroscopic, thermal and single crystal structure investigations of 2-bromotrimesic acid and its trimethyl ester analogue. Journal of Molecular Structure, 1074 . pp. 542-548. ISSN 0022-2860

Cyanamide

Bhat, Shreesha V. and Robinson, David and Moses, John E. and Sharma, Pallavi (2016) Synthesis of oxadiazol-5-imines via the cyclizative capture of in situ generated cyanamide ions and nitrile oxides. Organic Letters, 18 (5). pp. 1100-1103. ISSN 1523-7060

Cyanation

Powell, Kimberley J. and Han, Li-Chen and Sharma, Pallavi and Moses, John E. (2014) Chemoselective palladium-catalyzed cyanation of alkenyl halides. Organic Letters, 16 (8). pp. 2158-2161. ISSN 1523-7060

Cycloaddition

Miao, Ru and Gramani, Subramanian G. and Lear, Martin J. (2009) Stereocontrolled entry to the tricyclo[3.3.0]oxoheptane core of bielschowskysin by a [2+2] cycloaddition of an allene-butenolide. Tetrahedron Letters, 50 (15). pp. 1731-1733. ISSN ISSN

Cycloalkenes

Nelson, D. J. and Ashworth, I. W. and Hillier, I. H. and Kyne, S. H. and Pandian, S. and Parkinson, J. A. and Percy, J. M. and Rinaudo, G. and Vincent, M. A. (2011) Why is RCM favoured over dimerisation? Predicting and estimating thermodynamic effective molarities by solution experiments and electronic structure calculations. Chemistry - A European Journal, 17 (46). pp. 13087-13094. ISSN 0947-6539

Cycloaromatization

Hirama, Masahiro and Akiyama, Kimio and Das, Parthasarathi and Mita, Takashi and Lear, Martin J. and Iida, Kyo-ichiro and Sato, Itaru and Yoshimura, Fumihiko and Usuki, Toyonobu and Tero-Kubota, Shozo (2006) Direct observation of ESR spectra of bicyclic nine-membered enediynes at ambient temperature. Heterocycles, 69 (1). pp. 83-89. ISSN 0385-5414

DMSO solvate

Gruber, Tobias and Helas, Stefanie F. and Seichter, Wilhelm and Weber, Edwin (2010) X-ray crystal structures of two solvent complexes involving positionally isomeric 9,10-anthraquinonecarboxylic acids and DMSO. Structural Chemistry, 21 (5). pp. 1079-1083. ISSN 1040-0400

DNA cleavage

Kobayashi, Shoji and Ashizawa, Shukuko and Takahashi, Yusuke and Sugiura, Yukio and Nagaoka, Makoto and Lear, Martin J. and Hirama, Masahiro (2001) The first total synthesis of N1999-A2: absolute stereochemistry and stereochemical implications into DNA cleavage. Journal of the American Chemical Society, 123 (45). pp. 11294-11295. ISSN 0002-7863

DNA sequence

Cousins, Alex R. O. and Ritson, Dougal and Sharma, Pallavi and Stevens, Malcolm F. G. and Moses, John E. and Searle, Mark S. (2014) Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences. Chemical Communications, 50 . pp. 15202-15205. ISSN 1359-7345

DNA-binding polyamides

Fallows, Andrew J. and Singh, Ishwar and Dondi, Ruggero and Cullis, Paul M. and Burley, Glenn A. (2014) Highly efficient synthesis of DNA-binding polyamides using a convergent fragment-based approach. Organic Letters, 16 (17). pp. 4654-4657. ISSN 1523-7060

Dehydrofluorination/zincation

Kyne, Sara H. and Percy, Jonathon M. and Pullin, Robert D. C. and Redmond, Joanna M. and Wilson, Peter G. (2011) One-pot near-ambient temperature syntheses of aryl(difluoroenol) derivatives from trifluoroethanol. Organic and Biomolecular Chemistry, 9 (24). pp. 8328-8339. ISSN 14770520

Density functional theory

Kyne, S. H. and Miles, J. A. L. and Percy, J. M. and Singh, K. (2012) Executing and rationalizing the synthesis of a difluorinated analogue of a ring-expanded calystegine B2. Journal of Organic Chemistry, 77 (2). pp. 991-998. ISSN 0022-3263

Kyne, S. H. and Schiesser, C. H. and Matsubara, H. (2008) Multiorbital interactions during acyl radical addition reactions involving imines and electron-rich olefins. Journal of Organic Chemistry, 73 (2). pp. 427-434. ISSN 0022-3263

Kyne, S. H. and Schiesser, C. H. and Matsubara, H. (2011) An ab initio and DFT study of radical addition reactions of imidoyl and thioyl radicals to methanimine. Organic and Biomolecular Chemistry, 9 (9). pp. 3217-3224. ISSN 1477-0520

Kyne, Sara and Schiesser, Carl H. and Matsubara, Hiroshi (2007) Multi-component orbital interactions during oxyacyl radical addition reactions involving imines and electron-rich olefins. Organic & Biomolecular Chemistry, 5 (24). pp. 3938-3943. ISSN 1477-0520

Kyne, Sara H. and Percy, Jonathon M. and Pullin, Robert D. C. and Redmond, Joanna M. and Wilson, Peter G. (2011) One-pot near-ambient temperature syntheses of aryl(difluoroenol) derivatives from trifluoroethanol. Organic and Biomolecular Chemistry, 9 (24). pp. 8328-8339. ISSN 14770520

Density functional theory calculations

Kyne, Sara H. and Aitken, Heather M. and Schiesser, Carl H. and Lacote, Emmanuel and Malacria, Max and Ollivier, Cyril and Fensterbank, Louis (2011) Intramolecular homolytic substitution of sulfinates and sulfinamides: a computational study. Organic and Biomolecular Chemistry, 9 (9). pp. 3331-3337. ISSN 1477-0520

Deoxy sugars

Pasari, Sandip and Ismail, Shareef M. and Wenk, Markus R. and Lear, Martin (2015) Preparation of azide biosynthetic surrogates of myo-Inositol. Tetrahedron Letters, 56 (20). pp. 2597-2601. ISSN 0040-4039

Detection of binding events

National University of Singapore (2013) A microparticle assembly. WO2013176625 A1.

Diels-Alder

Chavan, Subhash P. and Sharma, Pallavi and Ramakrishna, G. and Thakkar, Mahesh (2003) Iodine as an efficient catalyst in ionic Diels–Alder reactions of α,β-unsaturated acetals. Tetrahedron Letters, 44 (14). pp. 3001-3003. ISSN 0040-4039

Moore, Jonathan C. and Davies, E. Stephen and Walsh, Darren A. and Sharma, Pallavi and Moses, John E. (2014) Formal synthesis of kingianin A based upon a novel electrochemically-induced radical cation Diels–Alder reaction. Chemical communications, 50 (83). pp. 12523-12525. ISSN 1359-7345

Simon, Oliver and Reux, Bastien and La Clair, James J. and Lear, Martin J. (2010) Total synthesis confirms laetirobin as a formal Diels-Alder adduct. Chemistry - An Asian Journal, 5 (2). pp. 342-351. ISSN 1861-4728

Dimer

Sharma, Pallavi (2016) Biomimetic approaches towards the synthesis of complex dimeric natural products. Current Pharmaceutical Design . ISSN 1381-6128

Diterpenes

Lear, Martin (2016) Synthetic ventures into the furanocembranes: bielschowskysin and beyond. In: Lecture Tour, January 2016, Tokyo University, Tohoku University, Kyushu University, 5-22 January 2016, Japan.

Donor-?-Acceptor

Zhang, Wei and Fang, Zhen and Su, Mingjuan and Saeys, Mark and Liu, Bin (2009) A triphenylamine-based conjugated polymer with donor-π-acceptor architecture as organic sensitizer for dye-sensitized solar cells. Macromolecular Rapid Communications, 30 (18). pp. 1533-1537. ISSN 1022-1336

Drug discovery

Lear, Martin (2012) Total synthesis and drug pursuits: laetirobins, lipstatins, platensimycins. In: ZiNG Natural Products Conference 2012: Natural Products Synthesis and Biosynthesis, 10 - 13 February 2012, Lanzarote, Spain.

Lear, Martin (2011) Total synthesis and drug pursuits: laetirobins, lipstatins, platensimycins [ACP Tour, Japan]. In: Asia Core Program Lectureship Tour of Japan, 18-22 Dec 2011, Nagoya, Tokyo, and Tohoku, Japan.

Drug labelling

National University of Singapore (2012) Synthesis and use of fluorophore-tagged antimalarials. US20120100555 A1.

Drug off-targets

Yang, Peng-Yu and Liu, Kai and Ngai, Mun Hong and Lear, Martin J. and Wenk, Markus R. and Yao, Shao Q. (2010) Activity-based proteome profiling of potential cellular targets of Orlistat - an FDA-approved drug with anti-tumor activities. Journal of the American Chemical Society, 132 (2). pp. 656-666. ISSN 0002-7863

Drug resistance

National University of Singapore (2012) Synthesis and use of fluorophore-tagged antimalarials. US20120100555 A1.

Dye-Sensitized Solar Cells

Cai, Liping and Tsao, Hoi Nok and Zhang, Wei and Wang, Long and Xue, Zhaosheng and Grätzel, Michael and Liu, Bin (2013) Organic sensitizers with bridged triphenylamine donor units for efficient dye-sensitized solar cells. Advanced Energy Materials, 3 (2). pp. 200-205. ISSN 1614-6832

Zhang, Wei and Fang, Zhen and Su, Mingjuan and Saeys, Mark and Liu, Bin (2009) A triphenylamine-based conjugated polymer with donor-π-acceptor architecture as organic sensitizer for dye-sensitized solar cells. Macromolecular Rapid Communications, 30 (18). pp. 1533-1537. ISSN 1022-1336

Dye-sensitized Solar Cells

Warnan, Julien and Pellegrin, Yann and Blart, Errol and Odobel, Fabrice and Zhang, Wei and Liu, Bin and Babu, Veluru Jagadeesh and Ramakrishna, Seeram (2011) Application of poly(3-hexylthiophene) functionalized with an anchoring group in dye-sensitized solar cells. Macromolecular Rapid Communications, 32 (15). pp. 1190-1194. ISSN 1022-1336

Electrochemistry

Kyne, Sara H. and Lévêque, Christophe and Zheng, Shiwen and Fensterbank, Louis and Jutand, Anny and Ollivier, Cyril (2016) Iron(II) catalyzed reductive radical cyclization reactions of bromoacetals in the presence of NaBH4: optimization studies and mechanistic insights. Tetrahedron, 72 (48). 7727 - 7737. ISSN 0040-4020

Moore, Jonathan C. and Davies, E. Stephen and Walsh, Darren A. and Sharma, Pallavi and Moses, John E. (2014) Formal synthesis of kingianin A based upon a novel electrochemically-induced radical cation Diels–Alder reaction. Chemical communications, 50 (83). pp. 12523-12525. ISSN 1359-7345

Electrocyclisation

Burnley, James and Ralph, Michael and Sharma, Pallavi and Moses, John E. (2011) Biomimetic electrocyclisation reactions towards polyketide-derived natural products. In: Biomimetic Organic Synthesis. Wiley-VCH, Weinheim. ISBN 9783527325801, 9783527634606

Electrocycllisation

Sharma, Pallavi and Powell, Kimberley J. and Burnley, James and Moses, John E. and Awaad, Amani S. (2011) Total synthesis of polypropionate derived y-pyrone natural products. Synthesis, 18 . pp. 2865-2892. ISSN 0039-7881

Enantiodivergent

Ghosh, Shibaji K. and Butler, Mark S. and Lear, Martin J. (2012) Synthesis of 2-C-methylerythritols and 2-C-methylthreitols via enantiodivergent Sharpless dihydroxylation of trisubstituted olefins. Tetrahedron Letters, 53 (22). pp. 2706-2708. ISSN 0040-4039

Epoxidation reaction

Kyne, S. H. and Miles, J. A. L. and Percy, J. M. and Singh, K. (2012) Executing and rationalizing the synthesis of a difluorinated analogue of a ring-expanded calystegine B2. Journal of Organic Chemistry, 77 (2). pp. 991-998. ISSN 0022-3263

Erythrulose

Kobayashi, Shoji and Das, Parthasarathi and Wang, Guang Xing and Mita, Takashi and Lear, Martin J. and Hirama, Masahiro (2002) Diastereoselective additions of ethynyl Grignard reagent to erythrulose derivatives. Chemistry Letters, 31 (3). pp. 300-301. ISSN 0366-7022

Falcitidin

Kotturi, Santosh R. and Somanadhan, Brinda and Ch’ng, Jun-Hong and Tan, Kevin S.-W. and Butler, Mark S. and Lear, Martin J. (2014) Diverted total synthesis of falcitidin acyl tetrapeptides as new antimalarial leads. Tetrahedron Letters, 55 (11). pp. 1949-1951. ISSN 0040-4039

Fatty acid synthase

Ngai, Mun H. and Yang, Peng-Yu and Liu, Kai and Shen, Yuan and Wenk, Markus R. and Yao, Shao Q. and Lear, Martin J. (2010) Click-based synthesis and proteomic profiling of lipstatin analogues. Chemical Communications, 46 (44). p. 8335. ISSN 1359-7345

Fluorescence

Gruber, Tobias and Fischer, Conrad and Felsmann, Marika and Seichter, Wilhelm and Weber, Edwin (2009) Calix[4]arenes featuring a direct lower rim attachment of dansyl groups. Synthesis, fluorescence properties and first report on crystal structures. Organic & Biomolecular Chemistry, 7 (23). pp. 4904-4917. ISSN 1477-0520

Fluorescent immuno-affinity label

Rodríguez, Abimael D. and Lear, Martin J. and La Clair, James J. (2008) Identification of the binding of sceptrin to MreB via a bidirectional affinity protocol. Journal of the American Chemical Society, 130 (23). pp. 7256-7258. ISSN 0002-7863

Fluorescent labels

National University of Singapore (2012) Synthesis and use of fluorophore-tagged antimalarials. US20120100555 A1.

Fluorescent sensing

National University of Singapore (2013) A microparticle assembly. WO2013176625 A1.

Fluorescent-labeled probes

Song, Hong Y. and Ngai, Mun H. and Song, Zhen Y. and MacAry, Paul A. and Hobley, Jonathan and Lear, Martin J. (2009) Practical synthesis of maleimides and coumarin-linked probes for protein and antibody labelling via reduction of native disulfides. Organic & Biomolecular Chemistry, 7 (17). pp. 3400-3406. ISSN 1477-0520

Free radical carbonylation

Kyne, S. H. and Lin, C. Y. and Ryu, I. and Coote, M. L. and Schiesser, C. H. (2010) First determination of the rate constant for ring-closure of an azahexenoyl radical: 6-aza-7-ethyl-5-hexenoyl. Chemical Communications, 46 (35). pp. 6521-6523. ISSN 1359-7345

Free radical chemistry

Kyne, Sara and Aitken, Hesther M. and Horvat, Sonia M. and Lin, Ching Yeh and Coote, Michelle L. and Schiesser, Carl H. (2012) Homolytic substitution chemistry: from James Franz to antihypertensives. ChemInform, 43 (30). pp. 927-928. ISSN 0931-7597

Kyne, Sara and Schiesser, Carl H. (2012) Intramolecular homolytic substitutions in synthesis. In: Encyclopedia of Radicals in Chemistry, Biology and Materials. John Wiley and Sons, Ltd., Chichester, UK, pp. 629-654. ISBN 9781119953678

Friedel-Crafts

Eey, Stanley T.-C. and Lear, Martin J. (2014) Total synthesis of (−)-platensimycin by advancing oxocarbenium- and iminium-mediated catalytic methods. Chemistry - A European Journal, 20 (36). pp. 11556-11573. ISSN 0947-6539

Furanocembranoid

Yang, Eugene G. and Sekar, Karthik and Lear, Martin J. (2013) A macrolactonisation approach to the cembrane carbocycle of bielschowskysin. Tetrahedron Letters, 54 (33). pp. 4406-4408. ISSN 0040-4039

G-quadruplex

Cousins, Alex R. O. and Ritson, Dougal and Sharma, Pallavi and Stevens, Malcolm F. G. and Moses, John E. and Searle, Mark S. (2014) Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences. Chemical Communications, 50 . pp. 15202-15205. ISSN 1359-7345

Gas chromatography

Dharmawan, Jorry and Kasapis, Stefan and Sriramula, Praveena and Lear, Martin J. and Curran, Philip (2009) Evaluation of aroma-active compounds in Pontianak Orange Peel Oil (Citrus nobilis Lour. Var.microcarpaHassk.) by gas chromatography−olfactometry, aroma reconstitution, and omission test. Journal of Agricultural and Food Chemistry, 57 (1). pp. 239-244. ISSN 0021-8561

Globalisation

Lear, Martin J. and Salmons, Brian and Gunzburg, Walter H. and Dangerfield, John A. (2009) Singapore R&D and globetrotting. Biotechnology Journal, 4 (2). pp. 179-185. ISSN ISSN

Glycobiology

Lear, Martin and Reux, Bastien and Sekar, Karthik (2012) Chemical synthesis, modification and mimicry of the GPI anchor. In: GPI membrane anchors: the much needed link. Bentham Science Publishers Ltd, pp. 64-82. ISBN 9781608051236

Glycolipids

Ali, Asif and Wenk, Markus R. and Lear, Martin J. (2009) Total synthesis of a fully lipidated form of phosphatidyl-myo-inositol dimannoside (PIM-2) of Mycobacterium tuberculosis. Tetrahedron Letters, 50 (40). pp. 5664-5666. ISSN 0040-4039

Lear, Martin and Reux, Bastien and Sekar, Karthik (2012) Chemical synthesis, modification and mimicry of the GPI anchor. In: GPI membrane anchors: the much needed link. Bentham Science Publishers Ltd, pp. 64-82. ISBN 9781608051236

Pasari, Sandip and Ismail, Shareef M. and Wenk, Markus R. and Lear, Martin (2015) Preparation of azide biosynthetic surrogates of myo-Inositol. Tetrahedron Letters, 56 (20). pp. 2597-2601. ISSN 0040-4039

Glycosylation

Ohashi, Isao and Lear, Martin J. and Yoshimura, Fumihiko and Hirama, Masahiro (2004) Use of polystyrene-supported DBU in the synthesis and α-selective glycosylation study of the unstable Schmidt donor of L-kedarosamine. Organic Letters, 6 (5). pp. 719-722. ISSN 1523-7060

Grignard addition

Kobayashi, Shoji and Das, Parthasarathi and Wang, Guang Xing and Mita, Takashi and Lear, Martin J. and Hirama, Masahiro (2002) Diastereoselective additions of ethynyl Grignard reagent to erythrulose derivatives. Chemistry Letters, 31 (3). pp. 300-301. ISSN 0366-7022

Hairpin pyrrole-imidazole polyamides

Fallows, Andrew J. and Singh, Ishwar and Dondi, Ruggero and Cullis, Paul M. and Burley, Glenn A. (2014) Highly efficient synthesis of DNA-binding polyamides using a convergent fragment-based approach. Organic Letters, 16 (17). pp. 4654-4657. ISSN 1523-7060

Hole Transporter

Zhang, Wei and Zhu, Rui and Li, Feng and Wang, Qing and Liu, Bin (2011) High-performance solid-state organic dye sensitized solar cells with P3HT as hole transporter. The Journal of Physical Chemistry C, 115 (14). pp. 7038-7043. ISSN 1932-7447

Homogenous catalysis

Kyne, Sara H. and Lévêque, Christophe and Zheng, Shiwen and Fensterbank, Louis and Jutand, Anny and Ollivier, Cyril (2016) Iron(II) catalyzed reductive radical cyclization reactions of bromoacetals in the presence of NaBH4: optimization studies and mechanistic insights. Tetrahedron, 72 (48). 7727 - 7737. ISSN 0040-4020

Nelson, D. J. and Ashworth, I. W. and Hillier, I. H. and Kyne, S. H. and Pandian, S. and Parkinson, J. A. and Percy, J. M. and Rinaudo, G. and Vincent, M. A. (2011) Why is RCM favoured over dimerisation? Predicting and estimating thermodynamic effective molarities by solution experiments and electronic structure calculations. Chemistry - A European Journal, 17 (46). pp. 13087-13094. ISSN 0947-6539

Homolytic substitution

Kyne, Sara and Aitken, Hesther M. and Horvat, Sonia M. and Lin, Ching Yeh and Coote, Michelle L. and Schiesser, Carl H. (2012) Homolytic substitution chemistry: from James Franz to antihypertensives. ChemInform, 43 (30). pp. 927-928. ISSN 0931-7597

Kyne, Sara and Schiesser, Carl H. (2012) Intramolecular homolytic substitutions in synthesis. In: Encyclopedia of Radicals in Chemistry, Biology and Materials. John Wiley and Sons, Ltd., Chichester, UK, pp. 629-654. ISBN 9781119953678

Kyne, Sara H. and Aitken, Heather M. and Schiesser, Carl H. and Lacote, Emmanuel and Malacria, Max and Ollivier, Cyril and Fensterbank, Louis (2011) Intramolecular homolytic substitution of sulfinates and sulfinamides: a computational study. Organic and Biomolecular Chemistry, 9 (9). pp. 3331-3337. ISSN 1477-0520

Hybrid solar cell

Zhang, Wei and Zhu, Rui and Liu, Bin and Ramakrishna, Seeram (2012) High-performance hybrid solar cells employing metal-free organic dye modified TiO2 as photoelectrode. Applied Energy, 90 (1). pp. 305-308. ISSN 0306-2619

Hydrazone

Kyne, Sara and Schiesser, C. H. (2009) Ab initio studies of carbonyl radical additions to hydrazone systems. Australian Journal of Chemistry, 62 (7). pp. 728-733. ISSN 0004-9425

Hydrogen Bonding

Gruber, Tobias and Helas, Stefanie F. and Seichter, Wilhelm and Weber, Edwin (2010) X-ray crystal structures of two solvent complexes involving positionally isomeric 9,10-anthraquinonecarboxylic acids and DMSO. Structural Chemistry, 21 (5). pp. 1079-1083. ISSN 1040-0400

Imine

Kyne, S. H. and Schiesser, C. H. and Matsubara, H. (2008) Multiorbital interactions during acyl radical addition reactions involving imines and electron-rich olefins. Journal of Organic Chemistry, 73 (2). pp. 427-434. ISSN 0022-3263

Kyne, Sara and Schiesser, Carl H. and Matsubara, Hiroshi (2007) Multi-component orbital interactions during oxyacyl radical addition reactions involving imines and electron-rich olefins. Organic & Biomolecular Chemistry, 5 (24). pp. 3938-3943. ISSN 1477-0520

Immobilisation chemistry

Li, Y. and Song, H. Y. and Lear, M. J. and Gorelik, S. and Tomczak, N. and Hobley, J. (2008) Optical detection of photo-activated protein adsorption using Brewster angle microscopy. In: PhotonicsGlobal@Singapore, 2008. IPGC 2008, 8-11 Dec 2008, Singapore.

Immuno-affinity screening

Lear, Martin J. and Simon, Oliver and Foley, Timothy L. and Burkart, Michael D. and Baiga, Thomas J. and Noel, Joseph P. and DiPasquale, Antonio G. and Rheingold, Arnold L. and La Clair, James J. (2009) Laetirobin from the parasitic growth of Laetiporus sulphurous on Robinia pseudoacacia. Journal of Natural Products, 72 (11). pp. 1980-1987. ISSN 0163-3864

Inositol

Pasari, Sandip and Ismail, Shareef M. and Wenk, Markus R. and Lear, Martin (2015) Preparation of azide biosynthetic surrogates of myo-Inositol. Tetrahedron Letters, 56 (20). pp. 2597-2601. ISSN 0040-4039

Interfacial modification

Zhang, Wei and Zhu, Rui and Liu, Bin and Ramakrishna, Seeram (2012) High-performance hybrid solar cells employing metal-free organic dye modified TiO2 as photoelectrode. Applied Energy, 90 (1). pp. 305-308. ISSN 0306-2619

Intermolecular interactions

Gruber, Tobias and Bombicz, Petra and Seichter, Wilhelm and Weber, Edwin (2009) X-ray crystal structures and isostructurality calculation of calix[4]arenes with lower rim propyl and carboxylic acid or mixed carboxylic acid and ester substituents involving solvent complexes with methanol and ethanol. Journal of Structural Chemistry, 50 (3). pp. 522-531. ISSN 0022-4766

Katzsch, Felix and Gruber, Tobias and Weber, Edwin (2016) Trimethyl 3,3',3''-(benzene-1,3,5-triyl)tripropynoate. IUCrData . ISSN 2414-3146

Intermolecular radical addition

Kyne, S. H. and Schiesser, C. H. and Matsubara, H. (2008) Multiorbital interactions during acyl radical addition reactions involving imines and electron-rich olefins. Journal of Organic Chemistry, 73 (2). pp. 427-434. ISSN 0022-3263

Kyne, S. H. and Schiesser, C. H. and Matsubara, H. (2011) An ab initio and DFT study of radical addition reactions of imidoyl and thioyl radicals to methanimine. Organic and Biomolecular Chemistry, 9 (9). pp. 3217-3224. ISSN 1477-0520

Kyne, Sara and Schiesser, C. H. (2009) Ab initio studies of carbonyl radical additions to hydrazone systems. Australian Journal of Chemistry, 62 (7). pp. 728-733. ISSN 0004-9425

Kyne, Sara and Schiesser, Carl H. and Matsubara, Hiroshi (2007) Multi-component orbital interactions during oxyacyl radical addition reactions involving imines and electron-rich olefins. Organic & Biomolecular Chemistry, 5 (24). pp. 3938-3943. ISSN 1477-0520

Intramolecular

Kyne, Sara and Schiesser, Carl H. (2012) Intramolecular homolytic substitutions in synthesis. In: Encyclopedia of Radicals in Chemistry, Biology and Materials. John Wiley and Sons, Ltd., Chichester, UK, pp. 629-654. ISBN 9781119953678

Intramolecular cyclisation

Kyne, S. H. and Lin, C. Y. and Ryu, I. and Coote, M. L. and Schiesser, C. H. (2010) First determination of the rate constant for ring-closure of an azahexenoyl radical: 6-aza-7-ethyl-5-hexenoyl. Chemical Communications, 46 (35). pp. 6521-6523. ISSN 1359-7345

Iron

Kyne, Sara H. and Lévêque, Christophe and Zheng, Shiwen and Fensterbank, Louis and Jutand, Anny and Ollivier, Cyril (2016) Iron(II) catalyzed reductive radical cyclization reactions of bromoacetals in the presence of NaBH4: optimization studies and mechanistic insights. Tetrahedron, 72 (48). 7727 - 7737. ISSN 0040-4020

Isotope labelling

Das, Parthasarathi and Mita, Takashi and Lear, Martin and Hirama, Masahiro (2002) Synthesis of 13C-labelled, bicyclic mimetics of natural enediynes. Chemical Communications (22). pp. 2624-2625. ISSN 1359-7345

Usuki, Toyonobu and Mita, Takashi and Lear, Martin J. and Das, Parthasarathi and Yoshimura, Fumihiko and Inoue, Masayuki and Hirama, Masahiro and Akiyama, Kimio and Tero-Kubota, Shozo (2004) Spin trapping of 13C-labeled p-benzynes generated by Masamune–Bergman cyclization of bicyclic nine-membered enediynes. Angewandte Chemie International Edition, 43 (39). pp. 5249-5253. ISSN 1433-7851

Kinetics

MacDougall, P .E. and Aitken, H. M. and Scammells, P. J. and Kavanagh, Y. and Kyne, S. H. and Schiesser, C. H. (2012) 7-Selenabicyclo2.2.1heptane. Chemical Communications, 48 (73). pp. 9126-9128. ISSN 1359-7345

Kingianin A

Moore, Jonathan C. and Davies, E. Stephen and Walsh, Darren A. and Sharma, Pallavi and Moses, John E. (2014) Formal synthesis of kingianin A based upon a novel electrochemically-induced radical cation Diels–Alder reaction. Chemical communications, 50 (83). pp. 12523-12525. ISSN 1359-7345

Knoevenagel reaction

Brunton, V. G. and Lear, M. and McKeown, P. and Robins, D. J. and Workman, P. (1996) Synthesis and antiproliferative activity of tyrphostins containing quinoline moieties. Anti-Cancer Drug Design, 11 (6). pp. 463-483. ISSN 0266-9536

Brunton, V. G. and Lear, M. and Robins, D. J. and Williamson, S. and Workman, P. (1994) Synthesis and antiproliferative activity of tyrphostins containing heteroaromatic moieties. Anti-Cancer Drug Design, 9 (4). pp. 291-309. ISSN 0266-9536

Lactate dehydrogenase

Moorhouse, Adam D. and Spiteri, Christian and Sharma, Pallavi and Zloh, Mire and Moses, John E. (2011) Targeting glycolysis: a fragment based approach towards bifunctional inhibitors of hLDH-5. Chemical Communications, 47 (1). pp. 230-232. ISSN 1359-7345

Laser ablation

Lear, Martin and Hobley, Jonathan (2008) You make it, I break it. COSMOS, 04 (01). pp. 99-129. ISSN 0219-6077

Lead discovery

Lear, Martin J. and Simon, Oliver and Foley, Timothy L. and Burkart, Michael D. and Baiga, Thomas J. and Noel, Joseph P. and DiPasquale, Antonio G. and Rheingold, Arnold L. and La Clair, James J. (2009) Laetirobin from the parasitic growth of Laetiporus sulphurous on Robinia pseudoacacia. Journal of Natural Products, 72 (11). pp. 1980-1987. ISSN 0163-3864

MIRC

Chavan, Subhash P. and Sharma, Pallavi and Sivappa, Rasapalli and Bhadbhade, Mohan B. and Gonnade, Rajesh G. and Kalkote, Uttam R. (2003) Enantioselective synthesis of L-CCG-I. Journal of the American Chemical Society, 68 (17). pp. 6871-6819. ISSN 0002-7863

Macrocyclisation

Yang, Eugene G. and Sekar, Karthik and Lear, Martin J. (2013) A macrolactonisation approach to the cembrane carbocycle of bielschowskysin. Tetrahedron Letters, 54 (33). pp. 4406-4408. ISSN 0040-4039

Malaria

Ghosh, Shibaji K. and Butler, Mark S. and Lear, Martin J. (2012) Synthesis of 2-C-methylerythritols and 2-C-methylthreitols via enantiodivergent Sharpless dihydroxylation of trisubstituted olefins. Tetrahedron Letters, 53 (22). pp. 2706-2708. ISSN 0040-4039

Malaria detection

National University of Singapore (2012) Synthesis and use of fluorophore-tagged antimalarials. US20120100555 A1.

Maleimide reagents

Song, Hong Y. and Ngai, Mun H. and Song, Zhen Y. and MacAry, Paul A. and Hobley, Jonathan and Lear, Martin J. (2009) Practical synthesis of maleimides and coumarin-linked probes for protein and antibody labelling via reduction of native disulfides. Organic & Biomolecular Chemistry, 7 (17). pp. 3400-3406. ISSN 1477-0520

Mechanism

Hirama, Masahiro and Akiyama, Kimio and Das, Parthasarathi and Mita, Takashi and Lear, Martin J. and Iida, Kyo-ichiro and Sato, Itaru and Yoshimura, Fumihiko and Usuki, Toyonobu and Tero-Kubota, Shozo (2006) Direct observation of ESR spectra of bicyclic nine-membered enediynes at ambient temperature. Heterocycles, 69 (1). pp. 83-89. ISSN 0385-5414

Usuki, Toyonobu and Mita, Takashi and Lear, Martin J. and Das, Parthasarathi and Yoshimura, Fumihiko and Inoue, Masayuki and Hirama, Masahiro and Akiyama, Kimio and Tero-Kubota, Shozo (2004) Spin trapping of 13C-labeled p-benzynes generated by Masamune–Bergman cyclization of bicyclic nine-membered enediynes. Angewandte Chemie International Edition, 43 (39). pp. 5249-5253. ISSN 1433-7851

Merocyanine

Siebenhofer, Bernhard and Gorelik, Sergey and Lear, Martin J. and Song, Hong Yan and Nowak, Christoph and Hobley, Jonathan (2013) Transient absorption spectroscopy on spiropyran monolayers using nanosecond pump–probe Brewster angle reflectometry. Photochemical & Photobiological Sciences, 12 (5). pp. 848-853. ISSN 1474-905X

Merocyanines

Hobley, Jonathan and Lear, Martin and Fukumura, Hiroshi (2003) Photo-switching spiropyrans and related compounds. In: Photochemistry of organic molecules in isotropic and anisotropic media. Marcel Dekker, Inc, pp. 353-404. ISBN 9780824708832, 9780203014202

Metal-free organic dye

Zhang, Wei and Zhu, Rui and Liu, Bin and Ramakrishna, Seeram (2012) High-performance hybrid solar cells employing metal-free organic dye modified TiO2 as photoelectrode. Applied Energy, 90 (1). pp. 305-308. ISSN 0306-2619

Metathesis reactions

Nelson, D. J. and Ashworth, I. W. and Hillier, I. H. and Kyne, S. H. and Pandian, S. and Parkinson, J. A. and Percy, J. M. and Rinaudo, G. and Vincent, M. A. (2011) Why is RCM favoured over dimerisation? Predicting and estimating thermodynamic effective molarities by solution experiments and electronic structure calculations. Chemistry - A European Journal, 17 (46). pp. 13087-13094. ISSN 0947-6539

Methodology

Li, Jing and Lear, Martin and Kwon, Eunsang and Hayashi, Yujiro (2016) Mechanism of oxidative amidation of nitroalkanes with oxygen and amine nucleophiles using electrophilic iodine. Chemistry - A European Journal, 22 (16). pp. 5538-5542. ISSN 0947-6539

Mevalonate

Ghosh, Shibaji K. and Butler, Mark S. and Lear, Martin J. (2012) Synthesis of 2-C-methylerythritols and 2-C-methylthreitols via enantiodivergent Sharpless dihydroxylation of trisubstituted olefins. Tetrahedron Letters, 53 (22). pp. 2706-2708. ISSN 0040-4039

Michael addition

Lear, Martin J. and Hayashi, Yujiro (2013) Remote 1,6-stereocontrol by iminium-mediated organocatalytic events. ChemCatChem, 5 (12). pp. 3499-3501. ISSN 1867-3880

Mode-of-action

Lear, Martin (2013) Synthetic ventures into the platensimycins, bielschowskysins, lipstatins, and enediynes. In: Lecture Tour, July 2013, RIKEN, Waseda University, Keio University, Sophia University, Japan.

Molecular Conformation

Fischer, Conrad and Gruber, Tobias and Eissmann, Diana and Seichter, Wilhelm and Weber, Edwin (2011) Unusual behavior of a calix[4]arene featuring the coexistence of basic cone and 1,2-alternate conformations in a solvated crystal. Crystal Growth & Design, 11 (5). pp. 1989-1994. ISSN 1528-7483

Fischer, Conrad and Gruber, Tobias and Seichter, Wilhelm and Weber, Edwin (2011) Bridge-substituted calix[4]arenes: syntheses, conformations and application. Organic & Biomolecular Chemistry, 9 (11). pp. 4347-4352. ISSN 1477-0520

Gruber, Tobias and Fischer, Conrad and Seichter, Wilhelm and Bombicz, Petra and Weber, Edwin (2011) Upper rim site lipophilic calix[4]arenes as receptors for natural terpenes and functionally related solvent molecules: combined crystal structure and QMB sensor study. CrystEngComm, 13 (5). pp. 1422-1431. ISSN 1466-8033

Gruber, Tobias and Gruner, Margit and Fischer, Conrad and Seichter, Wilhelm and Bombicz, Petra and Weber, Edwin (2010) Conformational behaviour and first crystal structures of a calix[4]arene featuring a laterally positioned carboxylic acid function in unsolvated and solvent-complexed forms. New Journal of Chemistry, 34 (2). p. 250. ISSN 1144-0546

Gruber, Tobias and Peukert, Max and Schindler, Diana and Seichter, Wilhelm and Weber, Edwin and Bombicz, Petra (2008) Crystalline inclusion compounds of lower rim propyl substituted calix[4]arenes featuring different number and positions of the modifying groups. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 62 (3-4). pp. 311-324. ISSN 0923-0750

Gruber, Tobias and Seichter, Wilhelm and Weber, Edwin (2008) Crystal structures of a calix[4]arene controlled by two affixed pyrene units. Supramolecular Chemistry, 20 (8). pp. 753-760. ISSN 1061-0278

Gruner, Margit and Fischer, Conrad and Gruber, Tobias and Weber, Edwin (2010) Influence of laterally attached alkyl groups on the conformational behaviour of a basic calix[4]arene: combined NMR, molecular mechanics and X-ray study. Supramolecular Chemistry, 22 (4). pp. 256-266. ISSN 1061-0278

N-terminal fragment

Fallows, Andrew J. and Singh, Ishwar and Dondi, Ruggero and Cullis, Paul M. and Burley, Glenn A. (2014) Highly efficient synthesis of DNA-binding polyamides using a convergent fragment-based approach. Organic Letters, 16 (17). pp. 4654-4657. ISSN 1523-7060

NMR spectroscopy

Kyne, Sara H. and Lévêque, Christophe and Zheng, Shiwen and Fensterbank, Louis and Jutand, Anny and Ollivier, Cyril (2016) Iron(II) catalyzed reductive radical cyclization reactions of bromoacetals in the presence of NaBH4: optimization studies and mechanistic insights. Tetrahedron, 72 (48). 7727 - 7737. ISSN 0040-4020

NMR study

Bürger, Marcel and Katzsch, Felix and Brendler, Erica and Gruber, Tobias (2015) Synthesis of macrocyclic receptors with intrinsic fluorescence featuring quinizarin moieties. The Journal of Organic Chemistry, 80 (10). pp. 4882-4892. ISSN 0022-3263

Natural Product

Ghosh, Shibaji K. and Somanadhan, Brinda and Tan, Kevin S.-W. and Butler, Mark S. and Lear, Martin J. (2012) Absolute configuration and total synthesis of a novel antimalarial lipopeptide by the de novo preparation of chiral nonproteinogenic amino acids. Organic Letters, 14 (6). pp. 1560-1563. ISSN 1523-7060

Moore, Jonathan C. and Davies, E. Stephen and Walsh, Darren A. and Sharma, Pallavi and Moses, John E. (2014) Formal synthesis of kingianin A based upon a novel electrochemically-induced radical cation Diels–Alder reaction. Chemical communications, 50 (83). pp. 12523-12525. ISSN 1359-7345

Natural Products

Burnley, James and Ralph, Michael and Sharma, Pallavi and Moses, John E. (2011) Biomimetic electrocyclisation reactions towards polyketide-derived natural products. In: Biomimetic Organic Synthesis. Wiley-VCH, Weinheim. ISBN 9783527325801, 9783527634606

Sharma, Pallavi (2016) Biomimetic approaches towards the synthesis of complex dimeric natural products. Current Pharmaceutical Design . ISSN 1381-6128

Natural enediynes

Das, Parthasarathi and Mita, Takashi and Lear, Martin and Hirama, Masahiro (2002) Synthesis of 13C-labelled, bicyclic mimetics of natural enediynes. Chemical Communications (22). pp. 2624-2625. ISSN 1359-7345

Hirama, Masahiro and Akiyama, Kimio and Das, Parthasarathi and Mita, Takashi and Lear, Martin J. and Iida, Kyo-ichiro and Sato, Itaru and Yoshimura, Fumihiko and Usuki, Toyonobu and Tero-Kubota, Shozo (2006) Direct observation of ESR spectra of bicyclic nine-membered enediynes at ambient temperature. Heterocycles, 69 (1). pp. 83-89. ISSN 0385-5414

Kobayashi, Shoji and Ashizawa, Shukuko and Takahashi, Yusuke and Sugiura, Yukio and Nagaoka, Makoto and Lear, Martin J. and Hirama, Masahiro (2001) The first total synthesis of N1999-A2: absolute stereochemistry and stereochemical implications into DNA cleavage. Journal of the American Chemical Society, 123 (45). pp. 11294-11295. ISSN 0002-7863

Koyama, Yasuhito and Lear, Martin J. and Yoshimura, Fumihiko and Ohashi, Isao and Mashimo, Tomoko and Hirama, Masahiro (2005) Efficient construction of the kedarcidin chromophore ansamacrolide. Organic Letters, 7 (2). pp. 267-270. ISSN 1523-7060

Lear, Martin (2015) Routes to nine-membered enediynes: not such a walk in the park. In: 64th Gordon Research Conference (GRC) on Natural Products 2015, July 26-31, 2015, Proctor Academy, Andover, NH, USA.

Lear, Martin and Hirai, Keiichiro and Yamada, Kei and Takahashi, Ryo and Hirama, Masahiro (2014) Total synthesis and biomimetic studies of nine-membered enediynes. In: CRC International Symposium: Synthesis and Applications of Functional Molecules and Materials Utilizing Biomolecules as a Motif, September 30, 2014, Catalytic Research Center, Hokkaido University, Japan.

Lear, Martin J. and Hirama, Masahiro (1999) Convenient route to derivatives of the 2-deoxysugar subunits of the kedarcidin chromophore: L-mycarose and L-kedarosamine. Tetrahedron Letters, 40 (26). pp. 4897-4900. ISSN 0040-4039

Lear, Martin J. and Yoshimura, Fumihiko and Hirama, Masahiro (2001) A direct and efficient α-selective glycosylation protocol for the kedarcidin sugar, L-mycarose: AgPF6 as a remarkable activator of 2-deoxythioglycosides. Angewandte Chemie International Edition, 40 (5). pp. 946-949. ISSN 1433-7851

Ohashi, Isao and Lear, Martin J. and Yoshimura, Fumihiko and Hirama, Masahiro (2004) Use of polystyrene-supported DBU in the synthesis and α-selective glycosylation study of the unstable Schmidt donor of L-kedarosamine. Organic Letters, 6 (5). pp. 719-722. ISSN 1523-7060

Usuki, Toyonobu and Mita, Takashi and Lear, Martin J. and Das, Parthasarathi and Yoshimura, Fumihiko and Inoue, Masayuki and Hirama, Masahiro and Akiyama, Kimio and Tero-Kubota, Shozo (2004) Spin trapping of 13C-labeled p-benzynes generated by Masamune–Bergman cyclization of bicyclic nine-membered enediynes. Angewandte Chemie International Edition, 43 (39). pp. 5249-5253. ISSN 1433-7851

Yoshimura, Fumihiko and Lear, Martin J. and Ohashi, Isao and Koyama, Yasuhito and Hirama, Masahiro (2007) Synthesis of the entire carbon framework of the kedarcidin chromophore aglycon. Chemical Communications (29). p. 3057. ISSN 1359-7345

Natural product

Dharmawan, Jorry and Kasapis, Stefan and Sriramula, Praveena and Lear, Martin J. and Curran, Philip (2009) Evaluation of aroma-active compounds in Pontianak Orange Peel Oil (Citrus nobilis Lour. Var.microcarpaHassk.) by gas chromatography−olfactometry, aroma reconstitution, and omission test. Journal of Agricultural and Food Chemistry, 57 (1). pp. 239-244. ISSN 0021-8561

Eey, Stanley T.-C. and Lear, Martin J. (2010) A bismuth(III)-catalyzed Friedel−Crafts cyclization and stereocontrolled organocatalytic approach to (−)-platensimycin. Organic Letters, 12 (23). pp. 5510-5513. ISSN 1523-7060

Ngai, Mun H. and Yang, Peng-Yu and Liu, Kai and Shen, Yuan and Wenk, Markus R. and Yao, Shao Q. and Lear, Martin J. (2010) Click-based synthesis and proteomic profiling of lipstatin analogues. Chemical Communications, 46 (44). p. 8335. ISSN 1359-7345

Simon, Oliver and Reux, Bastien and La Clair, James J. and Lear, Martin J. (2010) Total synthesis confirms laetirobin as a formal Diels-Alder adduct. Chemistry - An Asian Journal, 5 (2). pp. 342-351. ISSN 1861-4728

Natural products

Kotturi, Santosh R. and Somanadhan, Brinda and Ch’ng, Jun-Hong and Tan, Kevin S.-W. and Butler, Mark S. and Lear, Martin J. (2014) Diverted total synthesis of falcitidin acyl tetrapeptides as new antimalarial leads. Tetrahedron Letters, 55 (11). pp. 1949-1951. ISSN 0040-4039

Lear, Martin (2010) Exploring the glycolipidome via chemical mimicry. In: EMBO Conference Series: Chemical Biology 2010, 22 - 25 Sep 2010, EMBL Heidelberg, Germany.

Lear, Martin (2010) One small step for synthesis; one giant leap for total synthesis. In: 59th Natural Products Gordon Research Conference, July 25-30, 2010, Tilton, NH, USA.

Lear, Martin (2013) Synthetic ventures into the platensimycins, bielschowskysins, lipstatins, and enediynes. In: Lecture Tour, July 2013, RIKEN, Waseda University, Keio University, Sophia University, Japan.

Lear, Martin (2011) Total synthesis and drug pursuits: laetirobins, lipstatins, platensimycins [ACP Tour, Japan]. In: Asia Core Program Lectureship Tour of Japan, 18-22 Dec 2011, Nagoya, Tokyo, and Tohoku, Japan.

Lear, Martin (2012) Total synthesis and drug pursuits: the good, the bad, and the ugly. In: UK and European Lecture Tour, May - July 2012, St Andrews, Edinburgh, and Glasgow Universities (UK), EPFL (Lausanne, Switzerland), University of Strasbourg (France).

Lear, Martin J. and Simon, Oliver and Foley, Timothy L. and Burkart, Michael D. and Baiga, Thomas J. and Noel, Joseph P. and DiPasquale, Antonio G. and Rheingold, Arnold L. and La Clair, James J. (2009) Laetirobin from the parasitic growth of Laetiporus sulphurous on Robinia pseudoacacia. Journal of Natural Products, 72 (11). pp. 1980-1987. ISSN 0163-3864

Rodríguez, Abimael D. and Lear, Martin J. and La Clair, James J. (2008) Identification of the binding of sceptrin to MreB via a bidirectional affinity protocol. Journal of the American Chemical Society, 130 (23). pp. 7256-7258. ISSN 0002-7863

Negishi coupling

Kyne, Sara H. and Percy, Jonathon M. and Pullin, Robert D. C. and Redmond, Joanna M. and Wilson, Peter G. (2011) One-pot near-ambient temperature syntheses of aryl(difluoroenol) derivatives from trifluoroethanol. Organic and Biomolecular Chemistry, 9 (24). pp. 8328-8339. ISSN 14770520

Nitrile Oxide

Bhat, Shreesha V. and Robinson, David and Moses, John E. and Sharma, Pallavi (2016) Synthesis of oxadiazol-5-imines via the cyclizative capture of in situ generated cyanamide ions and nitrile oxides. Organic Letters, 18 (5). pp. 1100-1103. ISSN 1523-7060

Odor activity value

Dharmawan, Jorry and Kasapis, Stefan and Sriramula, Praveena and Lear, Martin J. and Curran, Philip (2009) Evaluation of aroma-active compounds in Pontianak Orange Peel Oil (Citrus nobilis Lour. Var.microcarpaHassk.) by gas chromatography−olfactometry, aroma reconstitution, and omission test. Journal of Agricultural and Food Chemistry, 57 (1). pp. 239-244. ISSN 0021-8561

Olfractometry

Dharmawan, Jorry and Kasapis, Stefan and Sriramula, Praveena and Lear, Martin J. and Curran, Philip (2009) Evaluation of aroma-active compounds in Pontianak Orange Peel Oil (Citrus nobilis Lour. Var.microcarpaHassk.) by gas chromatography−olfactometry, aroma reconstitution, and omission test. Journal of Agricultural and Food Chemistry, 57 (1). pp. 239-244. ISSN 0021-8561

Organic Dye

Zhang, Wei and Zhu, Rui and Li, Feng and Wang, Qing and Liu, Bin (2011) High-performance solid-state organic dye sensitized solar cells with P3HT as hole transporter. The Journal of Physical Chemistry C, 115 (14). pp. 7038-7043. ISSN 1932-7447

Organic Sensitizer

Zhang, Wei and Fang, Zhen and Su, Mingjuan and Saeys, Mark and Liu, Bin (2009) A triphenylamine-based conjugated polymer with donor-π-acceptor architecture as organic sensitizer for dye-sensitized solar cells. Macromolecular Rapid Communications, 30 (18). pp. 1533-1537. ISSN 1022-1336

Organic Sensitizers

Cai, Liping and Tsao, Hoi Nok and Zhang, Wei and Wang, Long and Xue, Zhaosheng and Grätzel, Michael and Liu, Bin (2013) Organic sensitizers with bridged triphenylamine donor units for efficient dye-sensitized solar cells. Advanced Energy Materials, 3 (2). pp. 200-205. ISSN 1614-6832

Organic methods

Kotturi, Santosh R. and Tan, Jason S. and Lear, Martin J. (2009) A mild method for the protection of alcohols using a para-methoxybenzylthio tetrazole (PMB-ST) under dual acid–base activation. Tetrahedron Letters, 50 (37). pp. 5267-5269. ISSN 0040-4039

Lear, Martin (2010) One small step for synthesis; one giant leap for total synthesis. In: 59th Natural Products Gordon Research Conference, July 25-30, 2010, Tilton, NH, USA.

Lear, Martin (2015) Routes to nine-membered enediynes: not such a walk in the park. In: 64th Gordon Research Conference (GRC) on Natural Products 2015, July 26-31, 2015, Proctor Academy, Andover, NH, USA.

Li, Jing and Lear, Martin and Hayashi, Yujiro (2016) Sterically demanding oxidative amidation of alpha-substituted malononitriles with amines using O2. Angewandte Chemie International Edition, 55 (31). pp. 9060-9064. ISSN 1433-7851

Organic synthesis

Das, Parthasarathi and Mita, Takashi and Lear, Martin and Hirama, Masahiro (2002) Synthesis of 13C-labelled, bicyclic mimetics of natural enediynes. Chemical Communications (22). pp. 2624-2625. ISSN 1359-7345

Gruber, Tobias and Gruner, Margit and Fischer, Conrad and Seichter, Wilhelm and Bombicz, Petra and Weber, Edwin (2010) Conformational behaviour and first crystal structures of a calix[4]arene featuring a laterally positioned carboxylic acid function in unsolvated and solvent-complexed forms. New Journal of Chemistry, 34 (2). p. 250. ISSN 1144-0546

Gruber, Tobias and Seichter, Wilhelm and Weber, Edwin (2008) Crystal structures of a calix[4]arene controlled by two affixed pyrene units. Supramolecular Chemistry, 20 (8). pp. 753-760. ISSN 1061-0278

Gruner, Margit and Fischer, Conrad and Gruber, Tobias and Weber, Edwin (2010) Influence of laterally attached alkyl groups on the conformational behaviour of a basic calix[4]arene: combined NMR, molecular mechanics and X-ray study. Supramolecular Chemistry, 22 (4). pp. 256-266. ISSN 1061-0278

Lear, Martin (2016) Synthetic ventures into the furanocembranes: bielschowskysin and beyond. In: Lecture Tour, January 2016, Tokyo University, Tohoku University, Kyushu University, 5-22 January 2016, Japan.

Lear, Martin and Hobley, Jonathan (2008) You make it, I break it. COSMOS, 04 (01). pp. 99-129. ISSN 0219-6077

Organic vapor sorption

Katzsch, Felix and Gruber, Tobias and Weber, Edwin (2016) Structural studies on inclusion compounds and solvent sorption behavior of gradually elongated wheel-and-axle-type diol hosts featuring lateral benzo[b]thiophene units. Journal of Molecular Structure, 1114 . pp. 48-64. ISSN 0022-2860

Organocatalysis

Hayashi, Yujiro and Shomura, Hiroki and Xu, Qianqian and Lear, Martin and Sato, Itaru (2015) Asymmetric aldol reaction of α,α-disubstituted acetaldehydes catalyzed by Ddphenylprolinol silyl ether for the construction of quaternary stereogenic centers. European Journal of Organic Chemistry, 20 . pp. 4316-4319. ISSN 1434-193X

Organocatalyst

Liu, Xiang Hui and Song, Hong Yan and Ma, Xiao Hua and Lear, Martin J. and Chen, Yu Zong (2010) Virtual screening prediction of new potential organocatalysts for direct aldol reactions. Journal of Molecular Catalysis A: Chemical, 319 (1-2). pp. 114-118. ISSN 1381-1169

Organohalogens

Lightfoot, Ian Peter and Colston, Belinda and Dahm, R (2000) Reductive destruction of chlorinated organics in molten salt. PhD thesis, De Montfort University.

Orlistat

Ngai, Mun H. and Yang, Peng-Yu and Liu, Kai and Shen, Yuan and Wenk, Markus R. and Yao, Shao Q. and Lear, Martin J. (2010) Click-based synthesis and proteomic profiling of lipstatin analogues. Chemical Communications, 46 (44). p. 8335. ISSN 1359-7345

Yang, Peng-Yu and Liu, Kai and Ngai, Mun Hong and Lear, Martin J. and Wenk, Markus R. and Yao, Shao Q. (2010) Activity-based proteome profiling of potential cellular targets of Orlistat - an FDA-approved drug with anti-tumor activities. Journal of the American Chemical Society, 132 (2). pp. 656-666. ISSN 0002-7863

Oxadiazol-5-imine

Bhat, Shreesha V. and Robinson, David and Moses, John E. and Sharma, Pallavi (2016) Synthesis of oxadiazol-5-imines via the cyclizative capture of in situ generated cyanamide ions and nitrile oxides. Organic Letters, 18 (5). pp. 1100-1103. ISSN 1523-7060

Oxazoles

Cousins, Alex R. O. and Ritson, Dougal and Sharma, Pallavi and Stevens, Malcolm F. G. and Moses, John E. and Searle, Mark S. (2014) Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences. Chemical Communications, 50 . pp. 15202-15205. ISSN 1359-7345

P3HT

Zhang, Wei and Zhu, Rui and Li, Feng and Wang, Qing and Liu, Bin (2011) High-performance solid-state organic dye sensitized solar cells with P3HT as hole transporter. The Journal of Physical Chemistry C, 115 (14). pp. 7038-7043. ISSN 1932-7447

Palladium catalysis

Powell, Kimberley J. and Han, Li-Chen and Sharma, Pallavi and Moses, John E. (2014) Chemoselective palladium-catalyzed cyanation of alkenyl halides. Organic Letters, 16 (8). pp. 2158-2161. ISSN 1523-7060

Peptide synthesis

Li, Jing and Lear, Martin and Hayashi, Yujiro (2016) Sterically demanding oxidative amidation of alpha-substituted malononitriles with amines using O2. Angewandte Chemie International Edition, 55 (31). pp. 9060-9064. ISSN 1433-7851

Peptides

Li, Jing and Lear, Martin and Kwon, Eunsang and Hayashi, Yujiro (2016) Mechanism of oxidative amidation of nitroalkanes with oxygen and amine nucleophiles using electrophilic iodine. Chemistry - A European Journal, 22 (16). pp. 5538-5542. ISSN 0947-6539

Photo-switches

Hobley, Jonathan and Lear, Martin and Fukumura, Hiroshi (2003) Photo-switching spiropyrans and related compounds. In: Photochemistry of organic molecules in isotropic and anisotropic media. Marcel Dekker, Inc, pp. 353-404. ISBN 9780824708832, 9780203014202

Photochemistry

Hobley, Jonathan and Lear, Martin and Fukumura, Hiroshi (2003) Photo-switching spiropyrans and related compounds. In: Photochemistry of organic molecules in isotropic and anisotropic media. Marcel Dekker, Inc, pp. 353-404. ISBN 9780824708832, 9780203014202

Plasmodium

National University of Singapore (2012) Synthesis and use of fluorophore-tagged antimalarials. US20120100555 A1.

Poly(3-hexylthiophene)

Warnan, Julien and Pellegrin, Yann and Blart, Errol and Odobel, Fabrice and Zhang, Wei and Liu, Bin and Babu, Veluru Jagadeesh and Ramakrishna, Seeram (2011) Application of poly(3-hexylthiophene) functionalized with an anchoring group in dye-sensitized solar cells. Macromolecular Rapid Communications, 32 (15). pp. 1190-1194. ISSN 1022-1336

Polyketide

Powell, Kimberley J. and Sharma, Pallavi and Richens, Joanna L. and Daviss, Benjamin M. and Moses, John E. and O'Shea, Paul (2012) Interactions of marine-derived γ-pyrone natural products with phospholipid membranes. Physical Chemistry Chemical Physics, 14 (42). pp. 14489-14491. ISSN 1463-9076

Polypropionate

Sharma, Pallavi and Powell, Kimberley J. and Burnley, James and Moses, John E. and Awaad, Amani S. (2011) Total synthesis of polypropionate derived y-pyrone natural products. Synthesis, 18 . pp. 2865-2892. ISSN 0039-7881

Polythiophene

Zhang, Wei and Zhu, Rui and Liu, Bin and Ramakrishna, Seeram (2012) High-performance hybrid solar cells employing metal-free organic dye modified TiO2 as photoelectrode. Applied Energy, 90 (1). pp. 305-308. ISSN 0306-2619

Protecting groups

Kotturi, Santosh R. and Tan, Jason S. and Lear, Martin J. (2009) A mild method for the protection of alcohols using a para-methoxybenzylthio tetrazole (PMB-ST) under dual acid–base activation. Tetrahedron Letters, 50 (37). pp. 5267-5269. ISSN 0040-4039

Protein tyrosine kinases

Brunton, V. G. and Lear, M. and McKeown, P. and Robins, D. J. and Workman, P. (1996) Synthesis and antiproliferative activity of tyrphostins containing quinoline moieties. Anti-Cancer Drug Design, 11 (6). pp. 463-483. ISSN 0266-9536

Brunton, V. G. and Lear, M. and Robins, D. J. and Williamson, S. and Workman, P. (1994) Synthesis and antiproliferative activity of tyrphostins containing heteroaromatic moieties. Anti-Cancer Drug Design, 9 (4). pp. 291-309. ISSN 0266-9536

QMB measurement

Gruber, Tobias and Fischer, Conrad and Seichter, Wilhelm and Bombicz, Petra and Weber, Edwin (2011) Upper rim site lipophilic calix[4]arenes as receptors for natural terpenes and functionally related solvent molecules: combined crystal structure and QMB sensor study. CrystEngComm, 13 (5). pp. 1422-1431. ISSN 1466-8033

Katzsch, Felix and Gruber, Tobias and Weber, Edwin (2015) Crystalline inclusion of wheel-and-axle diol hosts featuring benzo[b]thiophene units as a lateral construction element. Crystal Growth & Design, 15 (10). pp. 5047-5061. ISSN 1528-7483

Radical Cation

Moore, Jonathan C. and Davies, E. Stephen and Walsh, Darren A. and Sharma, Pallavi and Moses, John E. (2014) Formal synthesis of kingianin A based upon a novel electrochemically-induced radical cation Diels–Alder reaction. Chemical communications, 50 (83). pp. 12523-12525. ISSN 1359-7345

Radical cyclization

Kyne, Sara H. and Lévêque, Christophe and Zheng, Shiwen and Fensterbank, Louis and Jutand, Anny and Ollivier, Cyril (2016) Iron(II) catalyzed reductive radical cyclization reactions of bromoacetals in the presence of NaBH4: optimization studies and mechanistic insights. Tetrahedron, 72 (48). 7727 - 7737. ISSN 0040-4020

Radical reaction

Neves, A. C. and Aitken, H. M. and Kyne, S. H. and Fensterbank, L. and Lacote, E. and Malacria, M. and Ollivier, C. and Schiesser, C. H. (2012) Intramolecular homolytic substitution of seleninates: a computational study. Tetrahedron, 68 (1). pp. 323-328. ISSN 0040-4020

Reaction kinetics

Kyne, S. H. and Lin, C. Y. and Ryu, I. and Coote, M. L. and Schiesser, C. H. (2010) First determination of the rate constant for ring-closure of an azahexenoyl radical: 6-aza-7-ethyl-5-hexenoyl. Chemical Communications, 46 (35). pp. 6521-6523. ISSN 1359-7345

Reduction

Kyne, Sara H. and Lévêque, Christophe and Zheng, Shiwen and Fensterbank, Louis and Jutand, Anny and Ollivier, Cyril (2016) Iron(II) catalyzed reductive radical cyclization reactions of bromoacetals in the presence of NaBH4: optimization studies and mechanistic insights. Tetrahedron, 72 (48). 7727 - 7737. ISSN 0040-4020

SNAP-tag technology

Yang, Peng-Yu and Liu, Kai and Zhang, Chongjing and Chen, Grace Y. J. and Shen, Yuan and Ngai, Mun Hong and Lear, Martin J. and Yao, Shao Q. (2011) Chemical modification and organelle-specific localization of orlistat-like natural-product-based probes. Chemistry - An Asian Journal, 6 (10). pp. 2762-2775. ISSN 1861-4728

Selenium

MacDougall, P .E. and Aitken, H. M. and Scammells, P. J. and Kavanagh, Y. and Kyne, S. H. and Schiesser, C. H. (2012) 7-Selenabicyclo2.2.1heptane. Chemical Communications, 48 (73). pp. 9126-9128. ISSN 1359-7345

Neves, A. C. and Aitken, H. M. and Kyne, S. H. and Fensterbank, L. and Lacote, E. and Malacria, M. and Ollivier, C. and Schiesser, C. H. (2012) Intramolecular homolytic substitution of seleninates: a computational study. Tetrahedron, 68 (1). pp. 323-328. ISSN 0040-4020

Self-assembled monolayers

Siebenhofer, Bernhard and Gorelik, Sergey and Lear, Martin J. and Song, Hong Yan and Nowak, Christoph and Hobley, Jonathan (2013) Transient absorption spectroscopy on spiropyran monolayers using nanosecond pump–probe Brewster angle reflectometry. Photochemical & Photobiological Sciences, 12 (5). pp. 848-853. ISSN 1474-905X

Sensitized Solar Cells

Zhang, Wei and Zhu, Rui and Li, Feng and Wang, Qing and Liu, Bin (2011) High-performance solid-state organic dye sensitized solar cells with P3HT as hole transporter. The Journal of Physical Chemistry C, 115 (14). pp. 7038-7043. ISSN 1932-7447

Singapore

Lear, Martin J. and Salmons, Brian and Gunzburg, Walter H. and Dangerfield, John A. (2009) Singapore R&D and globetrotting. Biotechnology Journal, 4 (2). pp. 179-185. ISSN ISSN

Smart optical linkers

National University of Singapore (2013) A microparticle assembly. WO2013176625 A1.

Solid phase

Sharma, Pallavi and Moses, John E. (2010) Ethynyldiisopropylsilyl: a new alkynylsilane protecting group and click linker. Org. Lett., 12 (12). pp. 2860-2863. ISSN 1523-7060

Solid-State

Zhang, Wei and Zhu, Rui and Li, Feng and Wang, Qing and Liu, Bin (2011) High-performance solid-state organic dye sensitized solar cells with P3HT as hole transporter. The Journal of Physical Chemistry C, 115 (14). pp. 7038-7043. ISSN 1932-7447

Sonogashira

Yang, Eugene G. and Sekar, Karthik and Lear, Martin J. (2013) A macrolactonisation approach to the cembrane carbocycle of bielschowskysin. Tetrahedron Letters, 54 (33). pp. 4406-4408. ISSN 0040-4039

Spiropyran

Siebenhofer, Bernhard and Gorelik, Sergey and Lear, Martin J. and Song, Hong Yan and Nowak, Christoph and Hobley, Jonathan (2013) Transient absorption spectroscopy on spiropyran monolayers using nanosecond pump–probe Brewster angle reflectometry. Photochemical & Photobiological Sciences, 12 (5). pp. 848-853. ISSN 1474-905X

Spiropyran monolayers

Gorelik, Sergey and Hongyan, Song and Lear, Martin J. and Hobley, Jonathan (2010) Transient Brewster angle reflectometry of spiropyran monolayers. Photochemical and Photobiological Sciences, 9 (2). pp. 141-151. ISSN 1474-905X

Spiropyrans

Hobley, Jonathan and Lear, Martin and Fukumura, Hiroshi (2003) Photo-switching spiropyrans and related compounds. In: Photochemistry of organic molecules in isotropic and anisotropic media. Marcel Dekker, Inc, pp. 353-404. ISBN 9780824708832, 9780203014202

Stereoisomer synthesis

Kobayashi, Shoji and Das, Parthasarathi and Wang, Guang Xing and Mita, Takashi and Lear, Martin J. and Hirama, Masahiro (2002) Diastereoselective additions of ethynyl Grignard reagent to erythrulose derivatives. Chemistry Letters, 31 (3). pp. 300-301. ISSN 0366-7022

Stereoselective

Eey, Stanley T.-C. and Lear, Martin J. (2010) A bismuth(III)-catalyzed Friedel−Crafts cyclization and stereocontrolled organocatalytic approach to (−)-platensimycin. Organic Letters, 12 (23). pp. 5510-5513. ISSN 1523-7060

Stereoselective glycosylation

Lear, Martin J. and Yoshimura, Fumihiko and Hirama, Masahiro (2001) A direct and efficient α-selective glycosylation protocol for the kedarcidin sugar, L-mycarose: AgPF6 as a remarkable activator of 2-deoxythioglycosides. Angewandte Chemie International Edition, 40 (5). pp. 946-949. ISSN 1433-7851

Structure-Activity Relationship

Yang, Peng-Yu and Liu, Kai and Zhang, Chongjing and Chen, Grace Y. J. and Shen, Yuan and Ngai, Mun Hong and Lear, Martin J. and Yao, Shao Q. (2011) Chemical modification and organelle-specific localization of orlistat-like natural-product-based probes. Chemistry - An Asian Journal, 6 (10). pp. 2762-2775. ISSN 1861-4728

Sulfinamides

Kyne, Sara H. and Aitken, Heather M. and Schiesser, Carl H. and Lacote, Emmanuel and Malacria, Max and Ollivier, Cyril and Fensterbank, Louis (2011) Intramolecular homolytic substitution of sulfinates and sulfinamides: a computational study. Organic and Biomolecular Chemistry, 9 (9). pp. 3331-3337. ISSN 1477-0520

Sulfinates

Kyne, Sara H. and Aitken, Heather M. and Schiesser, Carl H. and Lacote, Emmanuel and Malacria, Max and Ollivier, Cyril and Fensterbank, Louis (2011) Intramolecular homolytic substitution of sulfinates and sulfinamides: a computational study. Organic and Biomolecular Chemistry, 9 (9). pp. 3331-3337. ISSN 1477-0520

Telomerase

Roe, S. and Gunaratnam, M. and Spiteri, C. and Sharma, Pallavi and Alharthy, R. D. and Neidle, S. and Moses, J. E. (2015) Synthesis and biological evaluation of hybrid acridine-HSP90 ligand conjugates as telomerase inhibitors. Organic and Biomolecular Chemistry, 13 . pp. 8500-8504. ISSN 1477-0520

Tetraols

Ghosh, Shibaji K. and Butler, Mark S. and Lear, Martin J. (2012) Synthesis of 2-C-methylerythritols and 2-C-methylthreitols via enantiodivergent Sharpless dihydroxylation of trisubstituted olefins. Tetrahedron Letters, 53 (22). pp. 2706-2708. ISSN 0040-4039

Tetrapeptide

Kotturi, Santosh R. and Somanadhan, Brinda and Ch’ng, Jun-Hong and Tan, Kevin S.-W. and Butler, Mark S. and Lear, Martin J. (2014) Diverted total synthesis of falcitidin acyl tetrapeptides as new antimalarial leads. Tetrahedron Letters, 55 (11). pp. 1949-1951. ISSN 0040-4039

Total synthesis

Ali, Asif and Wenk, Markus R. and Lear, Martin J. (2009) Total synthesis of a fully lipidated form of phosphatidyl-myo-inositol dimannoside (PIM-2) of Mycobacterium tuberculosis. Tetrahedron Letters, 50 (40). pp. 5664-5666. ISSN 0040-4039

Eey, Stanley T.-C. and Lear, Martin J. (2010) A bismuth(III)-catalyzed Friedel−Crafts cyclization and stereocontrolled organocatalytic approach to (−)-platensimycin. Organic Letters, 12 (23). pp. 5510-5513. ISSN 1523-7060

Kobayashi, Shoji and Ashizawa, Shukuko and Takahashi, Yusuke and Sugiura, Yukio and Nagaoka, Makoto and Lear, Martin J. and Hirama, Masahiro (2001) The first total synthesis of N1999-A2: absolute stereochemistry and stereochemical implications into DNA cleavage. Journal of the American Chemical Society, 123 (45). pp. 11294-11295. ISSN 0002-7863

Koyama, Yasuhito and Lear, Martin J. and Yoshimura, Fumihiko and Ohashi, Isao and Mashimo, Tomoko and Hirama, Masahiro (2005) Efficient construction of the kedarcidin chromophore ansamacrolide. Organic Letters, 7 (2). pp. 267-270. ISSN 1523-7060

Lear, Martin (2010) One small step for synthesis; one giant leap for total synthesis. In: 59th Natural Products Gordon Research Conference, July 25-30, 2010, Tilton, NH, USA.

Lear, Martin (2015) Routes to nine-membered enediynes: not such a walk in the park. In: 64th Gordon Research Conference (GRC) on Natural Products 2015, July 26-31, 2015, Proctor Academy, Andover, NH, USA.

Lear, Martin (2013) Synthetic ventures into the platensimycins, bielschowskysins, lipstatins, and enediynes. In: Lecture Tour, July 2013, RIKEN, Waseda University, Keio University, Sophia University, Japan.

Lear, Martin (2011) Total synthesis and drug pursuits: laetirobins, lipstatins, platensimycins [ACP Tour, Japan]. In: Asia Core Program Lectureship Tour of Japan, 18-22 Dec 2011, Nagoya, Tokyo, and Tohoku, Japan.

Lear, Martin (2012) Total synthesis and drug pursuits: the good, the bad, and the ugly. In: UK and European Lecture Tour, May - July 2012, St Andrews, Edinburgh, and Glasgow Universities (UK), EPFL (Lausanne, Switzerland), University of Strasbourg (France).

Lear, Martin and Hirai, Keiichiro and Yamada, Kei and Takahashi, Ryo and Hirama, Masahiro (2014) Total synthesis and biomimetic studies of nine-membered enediynes. In: CRC International Symposium: Synthesis and Applications of Functional Molecules and Materials Utilizing Biomolecules as a Motif, September 30, 2014, Catalytic Research Center, Hokkaido University, Japan.

Lear, Martin and Reux, Bastien and Sekar, Karthik (2012) Chemical synthesis, modification and mimicry of the GPI anchor. In: GPI membrane anchors: the much needed link. Bentham Science Publishers Ltd, pp. 64-82. ISBN 9781608051236

Lear, Martin and Yao, Shao Q. (2010) New directions for old drugs. Project Report. National University of Singapore, Singapore.

Ngai, Mun H. and Yang, Peng-Yu and Liu, Kai and Shen, Yuan and Wenk, Markus R. and Yao, Shao Q. and Lear, Martin J. (2010) Click-based synthesis and proteomic profiling of lipstatin analogues. Chemical Communications, 46 (44). p. 8335. ISSN 1359-7345

Sharma, Pallavi (2016) Biomimetic approaches towards the synthesis of complex dimeric natural products. Current Pharmaceutical Design . ISSN 1381-6128

Simon, Oliver and Reux, Bastien and La Clair, James J. and Lear, Martin J. (2010) Total synthesis confirms laetirobin as a formal Diels-Alder adduct. Chemistry - An Asian Journal, 5 (2). pp. 342-351. ISSN 1861-4728

Yang, Peng-Yu and Liu, Kai and Ngai, Mun Hong and Lear, Martin J. and Wenk, Markus R. and Yao, Shao Q. (2010) Activity-based proteome profiling of potential cellular targets of Orlistat - an FDA-approved drug with anti-tumor activities. Journal of the American Chemical Society, 132 (2). pp. 656-666. ISSN 0002-7863

Yoshimura, Fumihiko and Lear, Martin J. and Ohashi, Isao and Koyama, Yasuhito and Hirama, Masahiro (2007) Synthesis of the entire carbon framework of the kedarcidin chromophore aglycon. Chemical Communications (29). p. 3057. ISSN 1359-7345

Total synthesis studies

Lear, Martin (2016) Synthetic ventures into the furanocembranes: bielschowskysin and beyond. In: Lecture Tour, January 2016, Tokyo University, Tohoku University, Kyushu University, 5-22 January 2016, Japan.

Lear, Martin (2012) Total synthesis and drug pursuits: laetirobins, lipstatins, platensimycins. In: ZiNG Natural Products Conference 2012: Natural Products Synthesis and Biosynthesis, 10 - 13 February 2012, Lanzarote, Spain.

Lear, Martin J. and Hirama, Masahiro (1999) Convenient route to derivatives of the 2-deoxysugar subunits of the kedarcidin chromophore: L-mycarose and L-kedarosamine. Tetrahedron Letters, 40 (26). pp. 4897-4900. ISSN 0040-4039

Miao, Ru and Gramani, Subramanian G. and Lear, Martin J. (2009) Stereocontrolled entry to the tricyclo[3.3.0]oxoheptane core of bielschowskysin by a [2+2] cycloaddition of an allene-butenolide. Tetrahedron Letters, 50 (15). pp. 1731-1733. ISSN ISSN

Ohashi, Isao and Lear, Martin J. and Yoshimura, Fumihiko and Hirama, Masahiro (2004) Use of polystyrene-supported DBU in the synthesis and α-selective glycosylation study of the unstable Schmidt donor of L-kedarosamine. Organic Letters, 6 (5). pp. 719-722. ISSN 1523-7060

Transannular ring-opening

Kyne, S. H. and Miles, J. A. L. and Percy, J. M. and Singh, K. (2012) Executing and rationalizing the synthesis of a difluorinated analogue of a ring-expanded calystegine B2. Journal of Organic Chemistry, 77 (2). pp. 991-998. ISSN 0022-3263

Triazole

Roe, S. and Gunaratnam, M. and Spiteri, C. and Sharma, Pallavi and Alharthy, R. D. and Neidle, S. and Moses, J. E. (2015) Synthesis and biological evaluation of hybrid acridine-HSP90 ligand conjugates as telomerase inhibitors. Organic and Biomolecular Chemistry, 13 . pp. 8500-8504. ISSN 1477-0520

Trifluormethyl

Kotturi, Santosh R. and Somanadhan, Brinda and Ch’ng, Jun-Hong and Tan, Kevin S.-W. and Butler, Mark S. and Lear, Martin J. (2014) Diverted total synthesis of falcitidin acyl tetrapeptides as new antimalarial leads. Tetrahedron Letters, 55 (11). pp. 1949-1951. ISSN 0040-4039

Triphenylamine

Cai, Liping and Tsao, Hoi Nok and Zhang, Wei and Wang, Long and Xue, Zhaosheng and Grätzel, Michael and Liu, Bin (2013) Organic sensitizers with bridged triphenylamine donor units for efficient dye-sensitized solar cells. Advanced Energy Materials, 3 (2). pp. 200-205. ISSN 1614-6832

Zhang, Wei and Fang, Zhen and Su, Mingjuan and Saeys, Mark and Liu, Bin (2009) A triphenylamine-based conjugated polymer with donor-π-acceptor architecture as organic sensitizer for dye-sensitized solar cells. Macromolecular Rapid Communications, 30 (18). pp. 1533-1537. ISSN 1022-1336

Tyrophostins

Brunton, V. G. and Lear, M. and Robins, D. J. and Williamson, S. and Workman, P. (1994) Synthesis and antiproliferative activity of tyrphostins containing heteroaromatic moieties. Anti-Cancer Drug Design, 9 (4). pp. 291-309. ISSN 0266-9536

Tyrphostins

Brunton, V. G. and Lear, M. and McKeown, P. and Robins, D. J. and Workman, P. (1996) Synthesis and antiproliferative activity of tyrphostins containing quinoline moieties. Anti-Cancer Drug Design, 11 (6). pp. 463-483. ISSN 0266-9536

Virtual screening

Liu, Xiang Hui and Song, Hong Yan and Ma, Xiao Hua and Lear, Martin J. and Chen, Yu Zong (2010) Virtual screening prediction of new potential organocatalysts for direct aldol reactions. Journal of Molecular Catalysis A: Chemical, 319 (1-2). pp. 114-118. ISSN 1381-1169

X-ray diffraction

Fischer, Conrad and Gruber, Tobias and Eissmann, Diana and Seichter, Wilhelm and Weber, Edwin (2011) Unusual behavior of a calix[4]arene featuring the coexistence of basic cone and 1,2-alternate conformations in a solvated crystal. Crystal Growth & Design, 11 (5). pp. 1989-1994. ISSN 1528-7483

Fischer, Conrad and Gruber, Tobias and Seichter, Wilhelm and Schindler, Diana and Weber, Edwin (2008) 5,11,17,23-Tetra-tert-butyl-25,26,27,28-tetramethoxycalix[4]arene dichloromethane hemisolvate. Acta Crystallographica Section E: Structure Reports Online, 64 (4). o673-o673. ISSN 0365-110X

Fischer, Conrad and Gruber, Tobias and Seichter, Wilhelm and Weber, Edwin (2007) 5,11,17,23-Tetra-tert-butyl-25,26,27,28-tetramethoxycalix[4]arene tetrahydrofuran solvate. Acta Crystallographica Section E: Structure Reports Online, 63 (12). o4572-o4573. ISSN 0365-110X

Fischer, Conrad and Gruber, Tobias and Seichter, Wilhelm and Weber, Edwin (2011) Bridge-substituted calix[4]arenes: syntheses, conformations and application. Organic & Biomolecular Chemistry, 9 (11). pp. 4347-4352. ISSN 1477-0520

Fischer, Conrad and Gruber, Tobias and Seichter, Wilhelm and Weber, Edwin and Ibragimov, Bakhtiyar T. (2008) N-Cyclododecyl-5-(dimethylamino)naphthalene-1-sulfonamide. Acta Crystallographica Section E: Structure Reports Online, 64 (7). o1204. ISSN 0365-110X

Gruber, Tobias and Bombicz, Petra and Seichter, Wilhelm and Weber, Edwin (2009) X-ray crystal structures and isostructurality calculation of calix[4]arenes with lower rim propyl and carboxylic acid or mixed carboxylic acid and ester substituents involving solvent complexes with methanol and ethanol. Journal of Structural Chemistry, 50 (3). pp. 522-531. ISSN 0022-4766

Gruber, Tobias and Eissmann, Frank and Seichter, Wilhelm and Weber, Edwin (2010) 25-Allyloxy-5,11,17,23-tetra-tert-butyl-26,27,28-trihydroxycalix[4]arene chloroform disolvate. Acta Crystallographica Section C: Crystal Structure Communications, 66 (7). o334-o336. ISSN 0365-110X

Gruber, Tobias and Eissmann, Frank and Weber, Edwin and Schüürmann, Gerrit (2011) 1-Methyl-4-(4-nitrobenzoyl)pyridinium perchlorate. Acta Crystallographica Section E: Structure Reports Online, 67 (9). o2542-o2543. ISSN 0365-110X

Gruber, Tobias and Fischer, Conrad and Felsmann, Marika and Seichter, Wilhelm and Weber, Edwin (2009) Calix[4]arenes featuring a direct lower rim attachment of dansyl groups. Synthesis, fluorescence properties and first report on crystal structures. Organic & Biomolecular Chemistry, 7 (23). pp. 4904-4917. ISSN 1477-0520

Gruber, Tobias and Fischer, Conrad and Seichter, Wilhelm and Bombicz, Petra and Weber, Edwin (2011) Upper rim site lipophilic calix[4]arenes as receptors for natural terpenes and functionally related solvent molecules: combined crystal structure and QMB sensor study. CrystEngComm, 13 (5). pp. 1422-1431. ISSN 1466-8033

Gruber, Tobias and Gruner, Margit and Fischer, Conrad and Seichter, Wilhelm and Bombicz, Petra and Weber, Edwin (2010) Conformational behaviour and first crystal structures of a calix[4]arene featuring a laterally positioned carboxylic acid function in unsolvated and solvent-complexed forms. New Journal of Chemistry, 34 (2). p. 250. ISSN 1144-0546

Gruber, Tobias and Helas, Stefanie F. and Seichter, Wilhelm and Weber, Edwin (2010) X-ray crystal structures of two solvent complexes involving positionally isomeric 9,10-anthraquinonecarboxylic acids and DMSO. Structural Chemistry, 21 (5). pp. 1079-1083. ISSN 1040-0400

Gruber, Tobias and Peukert, Max and Schindler, Diana and Seichter, Wilhelm and Weber, Edwin and Bombicz, Petra (2008) Crystalline inclusion compounds of lower rim propyl substituted calix[4]arenes featuring different number and positions of the modifying groups. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 62 (3-4). pp. 311-324. ISSN 0923-0750

Gruber, Tobias and Schofield, Christopher J. and Thompson, Amber L. (2012) 3-Methoxy-3-oxopropanaminium chloride. Acta Crystallographica Section E: Structure Reports Online, 68 (3). o595. ISSN 0365-110X

Gruber, Tobias and Schofield, Christopher J. and Thompson, Amber L. (2012) Methyl 6-amino-6-oxohexanoate. Acta Crystallographica Section E: Structure Reports Online, 68 (3). o593-o594. ISSN 0365-110X

Gruber, Tobias and Seichter, Wilhelm and Weber, Edwin (2010) 1-(Hydroxymethyl)pyrene. Acta Crystallographica Section E: Structure Reports Online, 66 (2). o443. ISSN 0365-110X

Gruber, Tobias and Seichter, Wilhelm and Weber, Edwin (2006) 1-(Methoxymethyl)pyrene. Acta Crystallographica Section E: Structure Reports Online, 62 (6). o2569-o2570. ISSN 0365-110X

Gruber, Tobias and Seichter, Wilhelm and Weber, Edwin (2007) Crystal structure of 25,26,27,28-tetrabenzyloxy-5,11,17,23-tert-butylcalix- [4]arene, C72H80O4. Zeitschrift für Kristallographie - New Crystal Structures, 222 (3). pp. 222-224. ISSN 1433-7266

Gruber, Tobias and Seichter, Wilhelm and Weber, Edwin (2008) Crystal structures of a calix[4]arene controlled by two affixed pyrene units. Supramolecular Chemistry, 20 (8). pp. 753-760. ISSN 1061-0278

Katzsch, Felix and Gruber, Tobias and Weber, Edwin (2016) Crystal structures of functional building blocks derived from di(benzo[b]thien-2-yl)methane. Acta Crystallographica C: Structural Chemistry . ISSN 2053-2296

Münch, Alexander S. and Katzsch, Felix and Gruber, Tobias and Mertens, Florian O.R.L. (2014) Spectroscopic, thermal and single crystal structure investigations of 2-bromotrimesic acid and its trimethyl ester analogue. Journal of Molecular Structure, 1074 . pp. 542-548. ISSN 0022-2860

X-ray structure

Katzsch, Felix and Gruber, Tobias and Weber, Edwin (2016) Trimethyl 3,3',3''-(benzene-1,3,5-triyl)tripropynoate. IUCrData . ISSN 2414-3146

X-ray studies

Gruber, Tobias and Thompson, Amber L. and Odell, Barbara and Bombicz, Petra and Schofield, Christopher J. (2014) Conformational studies on substituted ε-caprolactams by X-ray crystallography and NMR spectroscopy. New Journal of Chemistry, 38 (12). pp. 5905-5917. ISSN 1144-0546

X-ray study

Gruber, Tobias and Nestler, Robert and Seichter, Wilhelm and Bombicz, Petra (2014) Crystal structures and isometricity comparison of methylated bisphenol F derivatives. Journal of Molecular Structure, 1056-7 . pp. 319-325. ISSN 0022-2860

Gruber, Tobias and Weber, Edwin and Seichter, Wilhelm and Bombicz, Petra and Csöregh, Ingeborg (2007) Versatile inclusion behaviour of a dinitrocalix[4]arene having two ester pendants: preparation and X-ray crystal structures of complexes. Supramolecular Chemistry, 18 (6). pp. 537-547. ISSN 1061-0278

Zirconium

Naeem, Ayesha and Ting, Valeska P. and Hintermair, Ulrich and Tian, Mi and Telford, Richard and Halim, Saaiba and Nowell, Harriott and Holynska, Malgorzata and Teat, Simon J. and Scowen, Ian J. and Nayak, Sanjit (2016) Mixed-linker approach in designing porous zirconium-based metal-organic frameworks with high hydrogen storage capacity. Chemical Communications, 52 (50). pp. 7826-7829. ISSN 1359-7345

alkyne silane

Sharma, Pallavi and Moses, John E. (2010) Ethynyldiisopropylsilyl: a new alkynylsilane protecting group and click linker. Org. Lett., 12 (12). pp. 2860-2863. ISSN 1523-7060

amidation

Li, Jing and Lear, Martin and Kawamoto, Yuya and Umemiya, Shigenobu and Wong, Alice and Kwon, Eunsang and Hayashi, Yujiro (2015) Oxidative amidation of nitroalkanes with amine nucleophiles using molecular oxygen and iodine. Angewandte Chemie International Edition, 54 (44). pp. 12986-12990. ISSN 1433-7851

amide

Sharma, Pallavi and Moorhouse, Adam D. and Moses, John E. (2011) Microwave enhanced tandem azidation-amidation of anilines. Synlett, 2011 (16). pp. 2384-2386. ISSN 0936-5214

amino acid

Chavan, Subhash P. and Sharma, Pallavi and Sivappa, Rasapalli and Bhadbhade, Mohan B. and Gonnade, Rajesh G. and Kalkote, Uttam R. (2003) Enantioselective synthesis of L-CCG-I. Journal of the American Chemical Society, 68 (17). pp. 6871-6819. ISSN 0002-7863

anti-tumour agents

Simon, Oliver and Reux, Bastien and La Clair, James J. and Lear, Martin J. (2010) Total synthesis confirms laetirobin as a formal Diels-Alder adduct. Chemistry - An Asian Journal, 5 (2). pp. 342-351. ISSN 1861-4728

antimalarial

Ghosh, Shibaji K. and Somanadhan, Brinda and Tan, Kevin S.-W. and Butler, Mark S. and Lear, Martin J. (2012) Absolute configuration and total synthesis of a novel antimalarial lipopeptide by the de novo preparation of chiral nonproteinogenic amino acids. Organic Letters, 14 (6). pp. 1560-1563. ISSN 1523-7060

antiparasitic agents

Yang, Peng-Yu and Wang, Min and Liu, Kai and Ngai, Mun Hong and Sheriff, Omar and Lear, Martin J. and Sze, Siu Kwan and He, Cynthia Y. and Yao, Shao Q. (2012) Parasite-based screening and proteome profiling reveal orlistat, an FDA-approved drug, as a potential anti trypanosoma brucei agent. Chemistry - A European Journal, 18 (27). pp. 8403-8413. ISSN 0947-6539

asymmetric induction

Lear, Martin J. and Hayashi, Yujiro (2013) Remote 1,6-stereocontrol by iminium-mediated organocatalytic events. ChemCatChem, 5 (12). pp. 3499-3501. ISSN 1867-3880

azide

Sharma, Pallavi and Moorhouse, Adam D. and Moses, John E. (2011) Microwave enhanced tandem azidation-amidation of anilines. Synlett, 2011 (16). pp. 2384-2386. ISSN 0936-5214

benzenoids

Yamada, Kei and Lear, Martin J. and Yamaguchi, Takaya and Yamashita, Shuji and Gridnev, Ilya D. and Hayashi, Yujiro and Hirama, Masahiro (2014) Biomimetic total synthesis of cyanosporaside aglycons from a single enediyne precursor through site-selective p-benzyne hydrochlorination. Angewandte Chemie International Edition, 53 (50). pp. 13902-13906. ISSN 1433-7851

benzothiophen

Katzsch, Felix and Gruber, Tobias and Weber, Edwin (2016) Crystal structures of functional building blocks derived from di(benzo[b]thien-2-yl)methane. Acta Crystallographica C: Structural Chemistry . ISSN 2053-2296

benzyne

Spiteri, Christian and Mason, Christopher and Zhang, Fengzhi and Ritson, Dougal J. and Sharma, Pallavi and Keeling, Steve and Moses, John E. (2010) An efficient entry to 1,2-benzisoxazoles via 1,3-dipolar cycloaddition of in situ generated nitrile oxides and benzyne. Organic and Biomolecular Chemistry Articles, 8 (11). pp. 2537-2542. ISSN 1477-0520

Spiteri, Christian and Sharma, Pallavi and Zhang, Fengzhi and Macdonald, Simon J. F. and Keeling, Steve and Moses, John E. (2010) An improved synthesis of 1,2-benzisoxazoles: TBAF mediated 1,3-dipolar cycloaddition of nitrile oxides and benzyne. Chemical Communications, 46 (8). pp. 1272-1274. ISSN 1359-7345

bioassay

Brennecke, Johannes and Ochs, Christopher J. and Boudhar, Aïcha and Reux, Bastien and Subramanian, Gomathy Sandhya and Lear, Martin J. and Trau, Dieter and Hobley, Jonathan (2014) Design, preparation and assessment of surface-immobilised tetraphenylethenes for biosensing applications. Applied Surface Science, 307 . pp. 475-481. ISSN 0169-4332

bioisotere

Katzsch, Felix and Gruber, Tobias and Weber, Edwin (2016) Crystal structures of functional building blocks derived from di(benzo[b]thien-2-yl)methane. Acta Crystallographica C: Structural Chemistry . ISSN 2053-2296

biomimetic synthesis

Sharma, Pallavi and Griffiths, Nicholas and Moses, John E. (2008) Biomimetic synthesis and structural revision of tridachiahydropyrone. Organic Letters, 10 (18). pp. 4025-4027. ISSN 1523-7060

Sharma, Pallavi and Lygo, Barry and Williams, Lewis and Moses, John E. (2009) Biomimetic synthesis and structural reassignment of the tridachiahydropyrones. Journal of the American Chemical Society, 131 (16). pp. 5966-5972. ISSN 0002-7863

bismuth

Eey, Stanley T.-C. and Lear, Martin J. (2014) Total synthesis of (−)-platensimycin by advancing oxocarbenium- and iminium-mediated catalytic methods. Chemistry - A European Journal, 20 (36). pp. 11556-11573. ISSN 0947-6539

bisphenol

Gruber, Tobias and Nestler, Robert and Seichter, Wilhelm and Bombicz, Petra (2014) Crystal structures and isometricity comparison of methylated bisphenol F derivatives. Journal of Molecular Structure, 1056-7 . pp. 319-325. ISSN 0022-2860

bmjdoi

Sharma, Pallavi (2016) Biomimetic approaches towards the synthesis of complex dimeric natural products. Current Pharmaceutical Design . ISSN 1381-6128

bmjgoldcheck

Hayashi, Yujiro and Shomura, Hiroki and Xu, Qianqian and Lear, Martin and Sato, Itaru (2015) Asymmetric aldol reaction of α,α-disubstituted acetaldehydes catalyzed by Ddphenylprolinol silyl ether for the construction of quaternary stereogenic centers. European Journal of Organic Chemistry, 20 . pp. 4316-4319. ISSN 1434-193X

Pasari, Sandip and Ismail, Shareef M. and Wenk, Markus R. and Lear, Martin (2015) Preparation of azide biosynthetic surrogates of myo-Inositol. Tetrahedron Letters, 56 (20). pp. 2597-2601. ISSN 0040-4039

calixarene

Bombicz, Petra and Gruber, Tobias and Fischer, Conrad and Weber, Edwin and Kálmán, Alajos (2014) Fine tuning of crystal architecture by intermolecular interactions: synthon engineering. CrystEngComm, 16 (18). p. 3646. ISSN 1466-8033

Fischer, Conrad and Gruber, Tobias and Eissmann, Diana and Seichter, Wilhelm and Weber, Edwin (2011) Unusual behavior of a calix[4]arene featuring the coexistence of basic cone and 1,2-alternate conformations in a solvated crystal. Crystal Growth & Design, 11 (5). pp. 1989-1994. ISSN 1528-7483

Fischer, Conrad and Gruber, Tobias and Seichter, Wilhelm and Weber, Edwin (2011) Bridge-substituted calix[4]arenes: syntheses, conformations and application. Organic & Biomolecular Chemistry, 9 (11). pp. 4347-4352. ISSN 1477-0520

Gruber, Tobias and Bombicz, Petra and Seichter, Wilhelm and Weber, Edwin (2009) X-ray crystal structures and isostructurality calculation of calix[4]arenes with lower rim propyl and carboxylic acid or mixed carboxylic acid and ester substituents involving solvent complexes with methanol and ethanol. Journal of Structural Chemistry, 50 (3). pp. 522-531. ISSN 0022-4766

Gruber, Tobias and Fischer, Conrad and Felsmann, Marika and Seichter, Wilhelm and Weber, Edwin (2009) Calix[4]arenes featuring a direct lower rim attachment of dansyl groups. Synthesis, fluorescence properties and first report on crystal structures. Organic & Biomolecular Chemistry, 7 (23). pp. 4904-4917. ISSN 1477-0520

Gruber, Tobias and Fischer, Conrad and Seichter, Wilhelm and Bombicz, Petra and Weber, Edwin (2011) Upper rim site lipophilic calix[4]arenes as receptors for natural terpenes and functionally related solvent molecules: combined crystal structure and QMB sensor study. CrystEngComm, 13 (5). pp. 1422-1431. ISSN 1466-8033

Gruber, Tobias and Gruner, Margit and Fischer, Conrad and Seichter, Wilhelm and Bombicz, Petra and Weber, Edwin (2010) Conformational behaviour and first crystal structures of a calix[4]arene featuring a laterally positioned carboxylic acid function in unsolvated and solvent-complexed forms. New Journal of Chemistry, 34 (2). p. 250. ISSN 1144-0546

Gruber, Tobias and Peukert, Max and Schindler, Diana and Seichter, Wilhelm and Weber, Edwin and Bombicz, Petra (2008) Crystalline inclusion compounds of lower rim propyl substituted calix[4]arenes featuring different number and positions of the modifying groups. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 62 (3-4). pp. 311-324. ISSN 0923-0750

Gruber, Tobias and Weber, Edwin and Seichter, Wilhelm and Bombicz, Petra and Csöregh, Ingeborg (2007) Versatile inclusion behaviour of a dinitrocalix[4]arene having two ester pendants: preparation and X-ray crystal structures of complexes. Supramolecular Chemistry, 18 (6). pp. 537-547. ISSN 1061-0278

Gruner, Margit and Fischer, Conrad and Gruber, Tobias and Weber, Edwin (2010) Influence of laterally attached alkyl groups on the conformational behaviour of a basic calix[4]arene: combined NMR, molecular mechanics and X-ray study. Supramolecular Chemistry, 22 (4). pp. 256-266. ISSN 1061-0278

caprolactam

Gruber, Tobias and Thompson, Amber L. and Odell, Barbara and Bombicz, Petra and Schofield, Christopher J. (2014) Conformational studies on substituted ε-caprolactams by X-ray crystallography and NMR spectroscopy. New Journal of Chemistry, 38 (12). pp. 5905-5917. ISSN 1144-0546

catenanes; interlocked molecules; links; supramolecular chemistry; template synthesis

Gil-Ramírez, Guzmán and Leigh, David A. and Stephens, Alexander J. (2015) Catenanes: fifty years of molecular links. Angewandte Chemie International Edition, 54 (21). pp. 6110-6150. ISSN 1433-7851

chemical proteomics

Yang, Peng-Yu and Liu, Kai and Zhang, Chongjing and Chen, Grace Y. J. and Shen, Yuan and Ngai, Mun Hong and Lear, Martin J. and Yao, Shao Q. (2011) Chemical modification and organelle-specific localization of orlistat-like natural-product-based probes. Chemistry - An Asian Journal, 6 (10). pp. 2762-2775. ISSN 1861-4728

chemisorption

Song, Hongyan and Gorelik, Sergey and Hobley, Jonathan and Li, Jiexun and Boudhar, AÏcha and Lear, Martin J. (2013) Pyrene emission from monolayers 'clicked' onto quartz. Journal of Molecular and Engineering Materials, 01 (01). pp. 1250007-1. ISSN 2251-2373

chlorinated organics

Lightfoot, Ian Peter and Colston, Belinda and Dahm, R (2000) Reductive destruction of chlorinated organics in molten salt. PhD thesis, De Montfort University.

click chemistry

Song, Hongyan and Gorelik, Sergey and Hobley, Jonathan and Li, Jiexun and Boudhar, AÏcha and Lear, Martin J. (2013) Pyrene emission from monolayers 'clicked' onto quartz. Journal of Molecular and Engineering Materials, 01 (01). pp. 1250007-1. ISSN 2251-2373

Yang, Peng-Yu and Liu, Kai and Zhang, Chongjing and Chen, Grace Y. J. and Shen, Yuan and Ngai, Mun Hong and Lear, Martin J. and Yao, Shao Q. (2011) Chemical modification and organelle-specific localization of orlistat-like natural-product-based probes. Chemistry - An Asian Journal, 6 (10). pp. 2762-2775. ISSN 1861-4728

computational modeling

Kyne, S. H. and Lin, C. Y. and Ryu, I. and Coote, M. L. and Schiesser, C. H. (2010) First determination of the rate constant for ring-closure of an azahexenoyl radical: 6-aza-7-ethyl-5-hexenoyl. Chemical Communications, 46 (35). pp. 6521-6523. ISSN 1359-7345

Neves, A. C. and Aitken, H. M. and Kyne, S. H. and Fensterbank, L. and Lacote, E. and Malacria, M. and Ollivier, C. and Schiesser, C. H. (2012) Intramolecular homolytic substitution of seleninates: a computational study. Tetrahedron, 68 (1). pp. 323-328. ISSN 0040-4020

conformational analysis

Bürger, Marcel and Katzsch, Felix and Brendler, Erica and Gruber, Tobias (2015) Synthesis of macrocyclic receptors with intrinsic fluorescence featuring quinizarin moieties. The Journal of Organic Chemistry, 80 (10). pp. 4882-4892. ISSN 0022-3263

conformational studies

Gruber, Tobias and Thompson, Amber L. and Odell, Barbara and Bombicz, Petra and Schofield, Christopher J. (2014) Conformational studies on substituted ε-caprolactams by X-ray crystallography and NMR spectroscopy. New Journal of Chemistry, 38 (12). pp. 5905-5917. ISSN 1144-0546

conjugate reduction

Eey, Stanley T.-C. and Lear, Martin J. (2014) Total synthesis of (−)-platensimycin by advancing oxocarbenium- and iminium-mediated catalytic methods. Chemistry - A European Journal, 20 (36). pp. 11556-11573. ISSN 0947-6539

conjugation

Lear, Martin J. and Hayashi, Yujiro (2013) Remote 1,6-stereocontrol by iminium-mediated organocatalytic events. ChemCatChem, 5 (12). pp. 3499-3501. ISSN 1867-3880

cyanoacetic acid

Warnan, Julien and Pellegrin, Yann and Blart, Errol and Odobel, Fabrice and Zhang, Wei and Liu, Bin and Babu, Veluru Jagadeesh and Ramakrishna, Seeram (2011) Application of poly(3-hexylthiophene) functionalized with an anchoring group in dye-sensitized solar cells. Macromolecular Rapid Communications, 32 (15). pp. 1190-1194. ISSN 1022-1336

cyclization

Kyne, S. H. and Schiesser, C.H. (2014) N,S-Dimethyldithiocarbamyl oxalates as precursors for determining kinetic parameters for oxyacyl radicals. Chemical Communications, 50 (81). pp. 12040-12042. ISSN 1359-7345

Yamada, Kei and Lear, Martin J. and Yamaguchi, Takaya and Yamashita, Shuji and Gridnev, Ilya D. and Hayashi, Yujiro and Hirama, Masahiro (2014) Biomimetic total synthesis of cyanosporaside aglycons from a single enediyne precursor through site-selective p-benzyne hydrochlorination. Angewandte Chemie International Edition, 53 (50). pp. 13902-13906. ISSN 1433-7851

cyclophane

Bürger, Marcel and Katzsch, Felix and Brendler, Erica and Gruber, Tobias (2015) Synthesis of macrocyclic receptors with intrinsic fluorescence featuring quinizarin moieties. The Journal of Organic Chemistry, 80 (10). pp. 4882-4892. ISSN 0022-3263

Fischer, Conrad and Gruber, Tobias and Eissmann, Diana and Seichter, Wilhelm and Weber, Edwin (2011) Unusual behavior of a calix[4]arene featuring the coexistence of basic cone and 1,2-alternate conformations in a solvated crystal. Crystal Growth & Design, 11 (5). pp. 1989-1994. ISSN 1528-7483

Fischer, Conrad and Gruber, Tobias and Seichter, Wilhelm and Weber, Edwin (2011) Bridge-substituted calix[4]arenes: syntheses, conformations and application. Organic & Biomolecular Chemistry, 9 (11). pp. 4347-4352. ISSN 1477-0520

Gruber, Tobias and Bombicz, Petra and Seichter, Wilhelm and Weber, Edwin (2009) X-ray crystal structures and isostructurality calculation of calix[4]arenes with lower rim propyl and carboxylic acid or mixed carboxylic acid and ester substituents involving solvent complexes with methanol and ethanol. Journal of Structural Chemistry, 50 (3). pp. 522-531. ISSN 0022-4766

Gruber, Tobias and Fischer, Conrad and Felsmann, Marika and Seichter, Wilhelm and Weber, Edwin (2009) Calix[4]arenes featuring a direct lower rim attachment of dansyl groups. Synthesis, fluorescence properties and first report on crystal structures. Organic & Biomolecular Chemistry, 7 (23). pp. 4904-4917. ISSN 1477-0520

Gruber, Tobias and Fischer, Conrad and Seichter, Wilhelm and Bombicz, Petra and Weber, Edwin (2011) Upper rim site lipophilic calix[4]arenes as receptors for natural terpenes and functionally related solvent molecules: combined crystal structure and QMB sensor study. CrystEngComm, 13 (5). pp. 1422-1431. ISSN 1466-8033

Gruber, Tobias and Gruner, Margit and Fischer, Conrad and Seichter, Wilhelm and Bombicz, Petra and Weber, Edwin (2010) Conformational behaviour and first crystal structures of a calix[4]arene featuring a laterally positioned carboxylic acid function in unsolvated and solvent-complexed forms. New Journal of Chemistry, 34 (2). p. 250. ISSN 1144-0546

Gruber, Tobias and Peukert, Max and Schindler, Diana and Seichter, Wilhelm and Weber, Edwin and Bombicz, Petra (2008) Crystalline inclusion compounds of lower rim propyl substituted calix[4]arenes featuring different number and positions of the modifying groups. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 62 (3-4). pp. 311-324. ISSN 0923-0750

Gruner, Margit and Fischer, Conrad and Gruber, Tobias and Weber, Edwin (2010) Influence of laterally attached alkyl groups on the conformational behaviour of a basic calix[4]arene: combined NMR, molecular mechanics and X-ray study. Supramolecular Chemistry, 22 (4). pp. 256-266. ISSN 1061-0278

cyclopropane

Chavan, Subhash P. and Sharma, Pallavi and Sivappa, Rasapalli and Bhadbhade, Mohan B. and Gonnade, Rajesh G. and Kalkote, Uttam R. (2003) Enantioselective synthesis of L-CCG-I. Journal of the American Chemical Society, 68 (17). pp. 6871-6819. ISSN 0002-7863

dimerization

Simon, Oliver and Reux, Bastien and La Clair, James J. and Lear, Martin J. (2010) Total synthesis confirms laetirobin as a formal Diels-Alder adduct. Chemistry - An Asian Journal, 5 (2). pp. 342-351. ISSN 1861-4728

diradicals

Yamada, Kei and Lear, Martin J. and Yamaguchi, Takaya and Yamashita, Shuji and Gridnev, Ilya D. and Hayashi, Yujiro and Hirama, Masahiro (2014) Biomimetic total synthesis of cyanosporaside aglycons from a single enediyne precursor through site-selective p-benzyne hydrochlorination. Angewandte Chemie International Edition, 53 (50). pp. 13902-13906. ISSN 1433-7851

drug discovery

Yang, Peng-Yu and Wang, Min and Liu, Kai and Ngai, Mun Hong and Sheriff, Omar and Lear, Martin J. and Sze, Siu Kwan and He, Cynthia Y. and Yao, Shao Q. (2012) Parasite-based screening and proteome profiling reveal orlistat, an FDA-approved drug, as a potential anti trypanosoma brucei agent. Chemistry - A European Journal, 18 (27). pp. 8403-8413. ISSN 0947-6539

electrocyclisation

Sharma, Pallavi and Griffiths, Nicholas and Moses, John E. (2008) Biomimetic synthesis and structural revision of tridachiahydropyrone. Organic Letters, 10 (18). pp. 4025-4027. ISSN 1523-7060

Sharma, Pallavi and Lygo, Barry and Williams, Lewis and Moses, John E. (2009) Biomimetic synthesis and structural reassignment of the tridachiahydropyrones. Journal of the American Chemical Society, 131 (16). pp. 5966-5972. ISSN 0002-7863

enediynes

Yamada, Kei and Lear, Martin J. and Yamaguchi, Takaya and Yamashita, Shuji and Gridnev, Ilya D. and Hayashi, Yujiro and Hirama, Masahiro (2014) Biomimetic total synthesis of cyanosporaside aglycons from a single enediyne precursor through site-selective p-benzyne hydrochlorination. Angewandte Chemie International Edition, 53 (50). pp. 13902-13906. ISSN 1433-7851

excimer

Song, Hongyan and Gorelik, Sergey and Hobley, Jonathan and Li, Jiexun and Boudhar, AÏcha and Lear, Martin J. (2013) Pyrene emission from monolayers 'clicked' onto quartz. Journal of Molecular and Engineering Materials, 01 (01). pp. 1250007-1. ISSN 2251-2373

falcipain

Somanadhan, Brinda and Kotturi, Santosh R. and Yan Leong, Chung and Glover, Robert P. and Huang, Yicun and Flotow, Horst and Buss, Antony D. and Lear, Martin J. and Butler, Mark S. (2013) Isolation and synthesis of falcitidin, a novel myxobacterial-derived acyltetrapeptide with activity against the malaria target falcipain-2. The Journal of Antibiotics, 66 (5). pp. 259-264. ISSN 0021-8820

falcitidin

Somanadhan, Brinda and Kotturi, Santosh R. and Yan Leong, Chung and Glover, Robert P. and Huang, Yicun and Flotow, Horst and Buss, Antony D. and Lear, Martin J. and Butler, Mark S. (2013) Isolation and synthesis of falcitidin, a novel myxobacterial-derived acyltetrapeptide with activity against the malaria target falcipain-2. The Journal of Antibiotics, 66 (5). pp. 259-264. ISSN 0021-8820

fluorescence

Bürger, Marcel and Katzsch, Felix and Brendler, Erica and Gruber, Tobias (2015) Synthesis of macrocyclic receptors with intrinsic fluorescence featuring quinizarin moieties. The Journal of Organic Chemistry, 80 (10). pp. 4882-4892. ISSN 0022-3263

fluorescent dye

Brennecke, Johannes and Ochs, Christopher J. and Boudhar, Aïcha and Reux, Bastien and Subramanian, Gomathy Sandhya and Lear, Martin J. and Trau, Dieter and Hobley, Jonathan (2014) Design, preparation and assessment of surface-immobilised tetraphenylethenes for biosensing applications. Applied Surface Science, 307 . pp. 475-481. ISSN 0169-4332

fluorescent probes

Song, Hongyan and Gorelik, Sergey and Hobley, Jonathan and Li, Jiexun and Boudhar, AÏcha and Lear, Martin J. (2013) Pyrene emission from monolayers 'clicked' onto quartz. Journal of Molecular and Engineering Materials, 01 (01). pp. 1250007-1. ISSN 2251-2373

gamma pyrone

Sharma, Pallavi and Moses, John E. (2010) Photochemical studies of the tridachiahydropyrones. Synlett, 2010 (4). pp. 525-528. ISSN 0936-5214

glycolysis

Moorhouse, Adam D. and Spiteri, Christian and Sharma, Pallavi and Zloh, Mire and Moses, John E. (2011) Targeting glycolysis: a fragment based approach towards bifunctional inhibitors of hLDH-5. Chemical Communications, 47 (1). pp. 230-232. ISSN 1359-7345

halogen bonding

Li, Jing and Lear, Martin and Kawamoto, Yuya and Umemiya, Shigenobu and Wong, Alice and Kwon, Eunsang and Hayashi, Yujiro (2015) Oxidative amidation of nitroalkanes with amine nucleophiles using molecular oxygen and iodine. Angewandte Chemie International Edition, 54 (44). pp. 12986-12990. ISSN 1433-7851

hazardous waste

Lightfoot, Ian Peter and Colston, Belinda and Dahm, R (2000) Reductive destruction of chlorinated organics in molten salt. PhD thesis, De Montfort University.

heteroaromatic compound

Katzsch, Felix and Gruber, Tobias and Weber, Edwin (2015) Crystalline inclusion of wheel-and-axle diol hosts featuring benzo[b]thiophene units as a lateral construction element. Crystal Growth & Design, 15 (10). pp. 5047-5061. ISSN 1528-7483

heterocycles

Bhat, Shreesha V. and Robinson, David and Moses, John E. and Sharma, Pallavi (2016) Synthesis of oxadiazol-5-imines via the cyclizative capture of in situ generated cyanamide ions and nitrile oxides. Organic Letters, 18 (5). pp. 1100-1103. ISSN 1523-7060

homolytic substitution

MacDougall, P .E. and Aitken, H. M. and Scammells, P. J. and Kavanagh, Y. and Kyne, S. H. and Schiesser, C. H. (2012) 7-Selenabicyclo2.2.1heptane. Chemical Communications, 48 (73). pp. 9126-9128. ISSN 1359-7345

Neves, A. C. and Aitken, H. M. and Kyne, S. H. and Fensterbank, L. and Lacote, E. and Malacria, M. and Ollivier, C. and Schiesser, C. H. (2012) Intramolecular homolytic substitution of seleninates: a computational study. Tetrahedron, 68 (1). pp. 323-328. ISSN 0040-4020

host-guest

Hernández-Alonso, D. and Zankowski, S. and Adriaenssens, L. and Ballester, P. (2015) Water-soluble aryl-extended calix[4]pyrroles with unperturbed aromatic cavities: synthesis and binding studies. Organic & Biomolecular Chemistry, 13 (4). pp. 1022-1029. ISSN 1477-0520

hydrogen storage

Naeem, Ayesha and Ting, Valeska P. and Hintermair, Ulrich and Tian, Mi and Telford, Richard and Halim, Saaiba and Nowell, Harriott and Holynska, Malgorzata and Teat, Simon J. and Scowen, Ian J. and Nayak, Sanjit (2016) Mixed-linker approach in designing porous zirconium-based metal-organic frameworks with high hydrogen storage capacity. Chemical Communications, 52 (50). pp. 7826-7829. ISSN 1359-7345

iminium

Lear, Martin J. and Hayashi, Yujiro (2013) Remote 1,6-stereocontrol by iminium-mediated organocatalytic events. ChemCatChem, 5 (12). pp. 3499-3501. ISSN 1867-3880

inclusion compound

Gruber, Tobias and Weber, Edwin and Seichter, Wilhelm and Bombicz, Petra and Csöregh, Ingeborg (2007) Versatile inclusion behaviour of a dinitrocalix[4]arene having two ester pendants: preparation and X-ray crystal structures of complexes. Supramolecular Chemistry, 18 (6). pp. 537-547. ISSN 1061-0278

Katzsch, Felix and Gruber, Tobias and Weber, Edwin (2016) Structural studies on inclusion compounds and solvent sorption behavior of gradually elongated wheel-and-axle-type diol hosts featuring lateral benzo[b]thiophene units. Journal of Molecular Structure, 1114 . pp. 48-64. ISSN 0022-2860

indole alkaloid

Chavan, Subhash P. and Sharma, Pallavi and Sivappa, R. and Kalkote, Uttam R. (2006) A ring closing metathesis approach to the indole alkaloid mitralactonine. Tetrahedron Letters, 47 (52). pp. 9301-9303. ISSN 0040-4039

Chavan, Subhash P. and Sharma, Pallavi and Sivappa, Rasapalli and Kalkote, Uttam R. (2007) A practical and facile approach towards indole alkaloids: (-)-mitralactonine. Synlett, 2007 (01). pp. 79-82. ISSN 0936-5214

iodination

Li, Jing and Lear, Martin and Kawamoto, Yuya and Umemiya, Shigenobu and Wong, Alice and Kwon, Eunsang and Hayashi, Yujiro (2015) Oxidative amidation of nitroalkanes with amine nucleophiles using molecular oxygen and iodine. Angewandte Chemie International Edition, 54 (44). pp. 12986-12990. ISSN 1433-7851

iodine

Chavan, Subhash P. and Sharma, Pallavi and Ramakrishna, G. and Thakkar, Mahesh (2003) Iodine as an efficient catalyst in ionic Diels–Alder reactions of α,β-unsaturated acetals. Tetrahedron Letters, 44 (14). pp. 3001-3003. ISSN 0040-4039

isometricity comparison

Gruber, Tobias and Nestler, Robert and Seichter, Wilhelm and Bombicz, Petra (2014) Crystal structures and isometricity comparison of methylated bisphenol F derivatives. Journal of Molecular Structure, 1056-7 . pp. 319-325. ISSN 0022-2860

isostructurality

Gruber, Tobias and Peukert, Max and Schindler, Diana and Seichter, Wilhelm and Weber, Edwin and Bombicz, Petra (2008) Crystalline inclusion compounds of lower rim propyl substituted calix[4]arenes featuring different number and positions of the modifying groups. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 62 (3-4). pp. 311-324. ISSN 0923-0750

kinetics

Kyne, S. H. and Schiesser, C.H. (2014) N,S-Dimethyldithiocarbamyl oxalates as precursors for determining kinetic parameters for oxyacyl radicals. Chemical Communications, 50 (81). pp. 12040-12042. ISSN 1359-7345

malaria

Somanadhan, Brinda and Kotturi, Santosh R. and Yan Leong, Chung and Glover, Robert P. and Huang, Yicun and Flotow, Horst and Buss, Antony D. and Lear, Martin J. and Butler, Mark S. (2013) Isolation and synthesis of falcitidin, a novel myxobacterial-derived acyltetrapeptide with activity against the malaria target falcipain-2. The Journal of Antibiotics, 66 (5). pp. 259-264. ISSN 0021-8820

metal-organic frameworks

Naeem, Ayesha and Ting, Valeska P. and Hintermair, Ulrich and Tian, Mi and Telford, Richard and Halim, Saaiba and Nowell, Harriott and Holynska, Malgorzata and Teat, Simon J. and Scowen, Ian J. and Nayak, Sanjit (2016) Mixed-linker approach in designing porous zirconium-based metal-organic frameworks with high hydrogen storage capacity. Chemical Communications, 52 (50). pp. 7826-7829. ISSN 1359-7345

microparticles

Brennecke, Johannes and Ochs, Christopher J. and Boudhar, Aïcha and Reux, Bastien and Subramanian, Gomathy Sandhya and Lear, Martin J. and Trau, Dieter and Hobley, Jonathan (2014) Design, preparation and assessment of surface-immobilised tetraphenylethenes for biosensing applications. Applied Surface Science, 307 . pp. 475-481. ISSN 0169-4332

mitralactonine

Chavan, Subhash P. and Sharma, Pallavi and Sivappa, R. and Kalkote, Uttam R. (2006) A ring closing metathesis approach to the indole alkaloid mitralactonine. Tetrahedron Letters, 47 (52). pp. 9301-9303. ISSN 0040-4039

Chavan, Subhash P. and Sharma, Pallavi and Sivappa, Rasapalli and Kalkote, Uttam R. (2007) A practical and facile approach towards indole alkaloids: (-)-mitralactonine. Synlett, 2007 (01). pp. 79-82. ISSN 0936-5214

mixed-linker

Naeem, Ayesha and Ting, Valeska P. and Hintermair, Ulrich and Tian, Mi and Telford, Richard and Halim, Saaiba and Nowell, Harriott and Holynska, Malgorzata and Teat, Simon J. and Scowen, Ian J. and Nayak, Sanjit (2016) Mixed-linker approach in designing porous zirconium-based metal-organic frameworks with high hydrogen storage capacity. Chemical Communications, 52 (50). pp. 7826-7829. ISSN 1359-7345

molecular overlay calculation

Gruber, Tobias and Thompson, Amber L. and Odell, Barbara and Bombicz, Petra and Schofield, Christopher J. (2014) Conformational studies on substituted ε-caprolactams by X-ray crystallography and NMR spectroscopy. New Journal of Chemistry, 38 (12). pp. 5905-5917. ISSN 1144-0546

mollusc

Sharma, Pallavi and Griffiths, Nicholas and Moses, John E. (2008) Biomimetic synthesis and structural revision of tridachiahydropyrone. Organic Letters, 10 (18). pp. 4025-4027. ISSN 1523-7060

Sharma, Pallavi and Moses, John E. (2010) Photochemical studies of the tridachiahydropyrones. Synlett, 2010 (4). pp. 525-528. ISSN 0936-5214

monochlorination

Yamada, Kei and Lear, Martin J. and Yamaguchi, Takaya and Yamashita, Shuji and Gridnev, Ilya D. and Hayashi, Yujiro and Hirama, Masahiro (2014) Biomimetic total synthesis of cyanosporaside aglycons from a single enediyne precursor through site-selective p-benzyne hydrochlorination. Angewandte Chemie International Edition, 53 (50). pp. 13902-13906. ISSN 1433-7851

morphotropism

Gruber, Tobias and Weber, Edwin and Seichter, Wilhelm and Bombicz, Petra and Csöregh, Ingeborg (2007) Versatile inclusion behaviour of a dinitrocalix[4]arene having two ester pendants: preparation and X-ray crystal structures of complexes. Supramolecular Chemistry, 18 (6). pp. 537-547. ISSN 1061-0278

myxobacteria

Somanadhan, Brinda and Kotturi, Santosh R. and Yan Leong, Chung and Glover, Robert P. and Huang, Yicun and Flotow, Horst and Buss, Antony D. and Lear, Martin J. and Butler, Mark S. (2013) Isolation and synthesis of falcitidin, a novel myxobacterial-derived acyltetrapeptide with activity against the malaria target falcipain-2. The Journal of Antibiotics, 66 (5). pp. 259-264. ISSN 0021-8820

oapaid

Powell, Kimberley J. and Han, Li-Chen and Sharma, Pallavi and Moses, John E. (2014) Chemoselective palladium-catalyzed cyanation of alkenyl halides. Organic Letters, 16 (8). pp. 2158-2161. ISSN 1523-7060

organic synthesis

Fischer, Conrad and Gruber, Tobias and Seichter, Wilhelm and Weber, Edwin (2011) Bridge-substituted calix[4]arenes: syntheses, conformations and application. Organic & Biomolecular Chemistry, 9 (11). pp. 4347-4352. ISSN 1477-0520

organocatalysis

Eey, Stanley T.-C. and Lear, Martin J. (2014) Total synthesis of (−)-platensimycin by advancing oxocarbenium- and iminium-mediated catalytic methods. Chemistry - A European Journal, 20 (36). pp. 11556-11573. ISSN 0947-6539

Lear, Martin J. and Hayashi, Yujiro (2013) Remote 1,6-stereocontrol by iminium-mediated organocatalytic events. ChemCatChem, 5 (12). pp. 3499-3501. ISSN 1867-3880

orlistat

Yang, Peng-Yu and Liu, Kai and Zhang, Chongjing and Chen, Grace Y. J. and Shen, Yuan and Ngai, Mun Hong and Lear, Martin J. and Yao, Shao Q. (2011) Chemical modification and organelle-specific localization of orlistat-like natural-product-based probes. Chemistry - An Asian Journal, 6 (10). pp. 2762-2775. ISSN 1861-4728

Yang, Peng-Yu and Wang, Min and Liu, Kai and Ngai, Mun Hong and Sheriff, Omar and Lear, Martin J. and Sze, Siu Kwan and He, Cynthia Y. and Yao, Shao Q. (2012) Parasite-based screening and proteome profiling reveal orlistat, an FDA-approved drug, as a potential anti trypanosoma brucei agent. Chemistry - A European Journal, 18 (27). pp. 8403-8413. ISSN 0947-6539

p-Benzynes

Usuki, Toyonobu and Mita, Takashi and Lear, Martin J. and Das, Parthasarathi and Yoshimura, Fumihiko and Inoue, Masayuki and Hirama, Masahiro and Akiyama, Kimio and Tero-Kubota, Shozo (2004) Spin trapping of 13C-labeled p-benzynes generated by Masamune–Bergman cyclization of bicyclic nine-membered enediynes. Angewandte Chemie International Edition, 43 (39). pp. 5249-5253. ISSN 1433-7851

peptide formation

Li, Jing and Lear, Martin and Kawamoto, Yuya and Umemiya, Shigenobu and Wong, Alice and Kwon, Eunsang and Hayashi, Yujiro (2015) Oxidative amidation of nitroalkanes with amine nucleophiles using molecular oxygen and iodine. Angewandte Chemie International Edition, 54 (44). pp. 12986-12990. ISSN 1433-7851

phochemical

Sharma, Pallavi and Moses, John E. (2010) Photochemical studies of the tridachiahydropyrones. Synlett, 2010 (4). pp. 525-528. ISSN 0936-5214

photochemical

Sharma, Pallavi and Lygo, Barry and Williams, Lewis and Moses, John E. (2009) Biomimetic synthesis and structural reassignment of the tridachiahydropyrones. Journal of the American Chemical Society, 131 (16). pp. 5966-5972. ISSN 0002-7863

polypropionate

Sharma, Pallavi and Griffiths, Nicholas and Moses, John E. (2008) Biomimetic synthesis and structural revision of tridachiahydropyrone. Organic Letters, 10 (18). pp. 4025-4027. ISSN 1523-7060

Sharma, Pallavi and Lygo, Barry and Williams, Lewis and Moses, John E. (2009) Biomimetic synthesis and structural reassignment of the tridachiahydropyrones. Journal of the American Chemical Society, 131 (16). pp. 5966-5972. ISSN 0002-7863

Sharma, Pallavi and Moses, John E. (2010) Photochemical studies of the tridachiahydropyrones. Synlett, 2010 (4). pp. 525-528. ISSN 0936-5214

proteomics

Yang, Peng-Yu and Wang, Min and Liu, Kai and Ngai, Mun Hong and Sheriff, Omar and Lear, Martin J. and Sze, Siu Kwan and He, Cynthia Y. and Yao, Shao Q. (2012) Parasite-based screening and proteome profiling reveal orlistat, an FDA-approved drug, as a potential anti trypanosoma brucei agent. Chemistry - A European Journal, 18 (27). pp. 8403-8413. ISSN 0947-6539

pyrene

Gruber, Tobias and Seichter, Wilhelm and Weber, Edwin (2006) 1-(Methoxymethyl)pyrene. Acta Crystallographica Section E: Structure Reports Online, 62 (6). o2569-o2570. ISSN 0365-110X

Gruber, Tobias and Seichter, Wilhelm and Weber, Edwin (2008) Crystal structures of a calix[4]arene controlled by two affixed pyrene units. Supramolecular Chemistry, 20 (8). pp. 753-760. ISSN 1061-0278

Song, Hongyan and Gorelik, Sergey and Hobley, Jonathan and Li, Jiexun and Boudhar, AÏcha and Lear, Martin J. (2013) Pyrene emission from monolayers 'clicked' onto quartz. Journal of Molecular and Engineering Materials, 01 (01). pp. 1250007-1. ISSN 2251-2373

radical

Kyne, S. H. and Schiesser, C.H. (2014) N,S-Dimethyldithiocarbamyl oxalates as precursors for determining kinetic parameters for oxyacyl radicals. Chemical Communications, 50 (81). pp. 12040-12042. ISSN 1359-7345

reagentless assay

Brennecke, Johannes and Ochs, Christopher J. and Boudhar, Aïcha and Reux, Bastien and Subramanian, Gomathy Sandhya and Lear, Martin J. and Trau, Dieter and Hobley, Jonathan (2014) Design, preparation and assessment of surface-immobilised tetraphenylethenes for biosensing applications. Applied Surface Science, 307 . pp. 475-481. ISSN 0169-4332

reductive destruction

Lightfoot, Ian Peter and Colston, Belinda and Dahm, R (2000) Reductive destruction of chlorinated organics in molten salt. PhD thesis, De Montfort University.

rhodanine-3-acetic acid

Warnan, Julien and Pellegrin, Yann and Blart, Errol and Odobel, Fabrice and Zhang, Wei and Liu, Bin and Babu, Veluru Jagadeesh and Ramakrishna, Seeram (2011) Application of poly(3-hexylthiophene) functionalized with an anchoring group in dye-sensitized solar cells. Macromolecular Rapid Communications, 32 (15). pp. 1190-1194. ISSN 1022-1336

ring closing metathesis

Chavan, Subhash P. and Sharma, Pallavi and Sivappa, R. and Kalkote, Uttam R. (2006) A ring closing metathesis approach to the indole alkaloid mitralactonine. Tetrahedron Letters, 47 (52). pp. 9301-9303. ISSN 0040-4039

self assembly

Song, Hongyan and Gorelik, Sergey and Hobley, Jonathan and Li, Jiexun and Boudhar, AÏcha and Lear, Martin J. (2013) Pyrene emission from monolayers 'clicked' onto quartz. Journal of Molecular and Engineering Materials, 01 (01). pp. 1250007-1. ISSN 2251-2373

self-defence

Sharma, Pallavi and Moses, John E. (2010) Photochemical studies of the tridachiahydropyrones. Synlett, 2010 (4). pp. 525-528. ISSN 0936-5214

sensor active material

Gruber, Tobias and Fischer, Conrad and Felsmann, Marika and Seichter, Wilhelm and Weber, Edwin (2009) Calix[4]arenes featuring a direct lower rim attachment of dansyl groups. Synthesis, fluorescence properties and first report on crystal structures. Organic & Biomolecular Chemistry, 7 (23). pp. 4904-4917. ISSN 1477-0520

solid state

Bombicz, Petra and Gruber, Tobias and Fischer, Conrad and Weber, Edwin and Kálmán, Alajos (2014) Fine tuning of crystal architecture by intermolecular interactions: synthon engineering. CrystEngComm, 16 (18). p. 3646. ISSN 1466-8033

solvent inclusion

Katzsch, Felix and Gruber, Tobias and Weber, Edwin (2015) Crystalline inclusion of wheel-and-axle diol hosts featuring benzo[b]thiophene units as a lateral construction element. Crystal Growth & Design, 15 (10). pp. 5047-5061. ISSN 1528-7483

synthon

Bombicz, Petra and Gruber, Tobias and Fischer, Conrad and Weber, Edwin and Kálmán, Alajos (2014) Fine tuning of crystal architecture by intermolecular interactions: synthon engineering. CrystEngComm, 16 (18). p. 3646. ISSN 1466-8033

tetrapeptide

Somanadhan, Brinda and Kotturi, Santosh R. and Yan Leong, Chung and Glover, Robert P. and Huang, Yicun and Flotow, Horst and Buss, Antony D. and Lear, Martin J. and Butler, Mark S. (2013) Isolation and synthesis of falcitidin, a novel myxobacterial-derived acyltetrapeptide with activity against the malaria target falcipain-2. The Journal of Antibiotics, 66 (5). pp. 259-264. ISSN 0021-8820

tetraphenylethene

Brennecke, Johannes and Ochs, Christopher J. and Boudhar, Aïcha and Reux, Bastien and Subramanian, Gomathy Sandhya and Lear, Martin J. and Trau, Dieter and Hobley, Jonathan (2014) Design, preparation and assessment of surface-immobilised tetraphenylethenes for biosensing applications. Applied Surface Science, 307 . pp. 475-481. ISSN 0169-4332

thio-acid

Sharma, Pallavi and Moorhouse, Adam D. and Moses, John E. (2011) Microwave enhanced tandem azidation-amidation of anilines. Synlett, 2011 (16). pp. 2384-2386. ISSN 0936-5214

total synthesis

Eey, Stanley T.-C. and Lear, Martin J. (2014) Total synthesis of (−)-platensimycin by advancing oxocarbenium- and iminium-mediated catalytic methods. Chemistry - A European Journal, 20 (36). pp. 11556-11573. ISSN 0947-6539

Ghosh, Shibaji K. and Somanadhan, Brinda and Tan, Kevin S.-W. and Butler, Mark S. and Lear, Martin J. (2012) Absolute configuration and total synthesis of a novel antimalarial lipopeptide by the de novo preparation of chiral nonproteinogenic amino acids. Organic Letters, 14 (6). pp. 1560-1563. ISSN 1523-7060

tridachiahydropyrone

Sharma, Pallavi and Lygo, Barry and Williams, Lewis and Moses, John E. (2009) Biomimetic synthesis and structural reassignment of the tridachiahydropyrones. Journal of the American Chemical Society, 131 (16). pp. 5966-5972. ISSN 0002-7863

trimesic acid homologue

Katzsch, Felix and Gruber, Tobias and Weber, Edwin (2016) Trimethyl 3,3',3''-(benzene-1,3,5-triyl)tripropynoate. IUCrData . ISSN 2414-3146

trypanosomiasis

Yang, Peng-Yu and Wang, Min and Liu, Kai and Ngai, Mun Hong and Sheriff, Omar and Lear, Martin J. and Sze, Siu Kwan and He, Cynthia Y. and Yao, Shao Q. (2012) Parasite-based screening and proteome profiling reveal orlistat, an FDA-approved drug, as a potential anti trypanosoma brucei agent. Chemistry - A European Journal, 18 (27). pp. 8403-8413. ISSN 0947-6539

umpolung

Li, Jing and Lear, Martin and Kawamoto, Yuya and Umemiya, Shigenobu and Wong, Alice and Kwon, Eunsang and Hayashi, Yujiro (2015) Oxidative amidation of nitroalkanes with amine nucleophiles using molecular oxygen and iodine. Angewandte Chemie International Edition, 54 (44). pp. 12986-12990. ISSN 1433-7851

water

Hernández-Alonso, D. and Zankowski, S. and Adriaenssens, L. and Ballester, P. (2015) Water-soluble aryl-extended calix[4]pyrroles with unperturbed aromatic cavities: synthesis and binding studies. Organic & Biomolecular Chemistry, 13 (4). pp. 1022-1029. ISSN 1477-0520

wheel-and-axle host

Katzsch, Felix and Gruber, Tobias and Weber, Edwin (2015) Crystalline inclusion of wheel-and-axle diol hosts featuring benzo[b]thiophene units as a lateral construction element. Crystal Growth & Design, 15 (10). pp. 5047-5061. ISSN 1528-7483

Katzsch, Felix and Gruber, Tobias and Weber, Edwin (2016) Structural studies on inclusion compounds and solvent sorption behavior of gradually elongated wheel-and-axle-type diol hosts featuring lateral benzo[b]thiophene units. Journal of Molecular Structure, 1114 . pp. 48-64. ISSN 0022-2860

This list was generated on Sat Dec 3 16:42:57 2016 GMT.