Items where Subject is "F Physical Sciences > F160 Organic Chemistry"

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'click' ligand 1 2-Deoxy sugars 3-dipolar addition 3-dipolar cycloaddition Ab initio and DFT calculations Ab initio structural calculations Acetone cyano hydrin Acyl ketene Aldol reaction Alkenyl nitrile Amino acids Anitmalarial agents Anitproliferative activity Anti-tumor activities Antibody labelling Antiproliferative activity Aryl halide Asymmetric catalysis Asymmetric resolution Asymmetric synthesis Bead microarray Benzisoxazole Bezisoxazole Bielschowskysin Binding affinity screening Bio-target identification Bio-targeting Biology Biomedicine Biomimetic Synthesis Biomimetic synthesis Biomimicry Biomolecular identification Biosynthesis Biotarget identification Biotechnology Bismuth Brewster angle microscopy Brewster angle reflectometry Bulgecinine C-terminal fragment CCG Cembranes Chemical characterisation Chemical proteomics Chemical reagent Chemistry Chitinophaga Click reaction Click-chemistry Computational chemistry Conjugate reduction Convergent synthetic strategy Coupling reagents Cyanation Cycloaddition Cycloalkenes Cycloaromatization DNA cleavage DNA sequence DNA-binding polyamides Dehydrofluorination/zincation Density functional theory Density functional theory calculations Deoxy sugars Detection of binding events Diels-Alder Drug discovery Drug labelling Drug off-targets Drug resistance Electrochemistry Electrocyclisation Electrocycllisation Enantiodivergent Epoxidation reaction Erythrulose Falcitidin Fatty acid synthase Fluorescent immuno-affinity label Fluorescent labels Fluorescent sensing Fluorescent-labeled probes Free radical carbonylation Free radical chemistry Friedel-Crafts Furanocembranoid G-quadruplex Gas chromatography Globalisation Glycobiology Glycolipids Glycosylation Grignard addition Hairpin pyrrole-imidazole polyamides Homogenous catalysis Homolytic substitution Hydrazone Imine Immobilisation chemistry Immuno-affinity screening Inositol Intermolecular radical addition Intramolecular Intramolecular cyclisation Isotope labelling Kinetics Kingianin A Knoevenagel reaction Lactate dehydrogenase Laser ablation Lead discovery MIRC Macrocyclisation Malaria Malaria detection Maleimide reagents Mechanism Merocyanine Merocyanines Metathesis reactions Mevalonate Michael addition Mode-of-action N-terminal fragment Natural Product Natural Products Natural enediynes Natural product Natural products Negishi coupling Odor activity value Olfractometry Organic methods Organic synthesis Organocatalysis Organocatalyst Organohalogens Orlistat Oxazoles Palladium catalysis Photo-switches Photochemistry Plasmodium Polyketide Polypropionate Protecting groups Protein tyrosine kinases Radical Cation Radical reaction Reaction kinetics SNAP-tag technology Selenium Self-assembled monolayers Singapore Smart optical linkers Solid phase Sonogashira Spiropyran Spiropyran monolayers Spiropyrans Stereoisomer synthesis Stereoselective Stereoselective glycosylation Structure-Activity Relationship Sulfinamides Sulfinates Tetraols Tetrapeptide Total synthesis Total synthesis studies Transannular ring-opening Trifluormethyl Tyrophostins Tyrphostins Virtual screening alkyne silane amidation amide amino acid anti-tumour agents antimalarial antiparasitic agents asymmetric induction azide benzenoids benzyne bioassay biomimetic synthesis bismuth bmjgoldcheck chemical proteomics chemisorption chlorinated organics click chemistry computational modeling conjugate reduction conjugation cyclization cyclopropane dimerization diradicals drug discovery electrocyclisation enediynes excimer falcipain falcitidin fluorescent dye fluorescent probes gamma pyrone glycolysis halogen bonding hazardous waste homolytic substitution host-guest iminium indole alkaloid iodination iodine kinetics malaria microparticles mitralactonine mollusc monochlorination myxobacteria oapaid organocatalysis orlistat p-Benzynes peptide formation phochemical photochemical polypropionate proteomics pyrene radical reagentless assay reductive destruction ring closing metathesis self assembly self-defence tetrapeptide tetraphenylethene thio-acid total synthesis tridachiahydropyrone trypanosomiasis umpolung water
Number of items at this level: 344.

'click' ligand

Cousins, Alex R. O. and Ritson, Dougal and Sharma, Pallavi and Stevens, Malcolm F. G. and Moses, John E. and Searle, Mark S. (2014) Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences. Chemical Communications, 50 . pp. 15202-15205. ISSN 1359-7345

1

Spiteri, Christian and Mason, Christopher and Zhang, Fengzhi and Ritson, Dougal J. and Sharma, Pallavi and Keeling, Steve and Moses, John E. (2010) An efficient entry to 1,2-benzisoxazoles via 1,3-dipolar cycloaddition of in situ generated nitrile oxides and benzyne. Organic and Biomolecular Chemistry Articles, 8 (11). pp. 2537-2542. ISSN 1477-0520

Spiteri, Christian and Sharma, Pallavi and Zhang, Fengzhi and Macdonald, Simon J. F. and Keeling, Steve and Moses, John E. (2010) An improved synthesis of 1,2-benzisoxazoles: TBAF mediated 1,3-dipolar cycloaddition of nitrile oxides and benzyne. Chemical Communications, 46 (8). pp. 1272-1274. ISSN 1359-7345

2-Deoxy sugars

Lear, Martin J. and Hirama, Masahiro (1999) Convenient route to derivatives of the 2-deoxysugar subunits of the kedarcidin chromophore: L-mycarose and L-kedarosamine. Tetrahedron Letters, 40 (26). pp. 4897-4900. ISSN 0040-4039

Lear, Martin J. and Yoshimura, Fumihiko and Hirama, Masahiro (2001) A direct and efficient α-selective glycosylation protocol for the kedarcidin sugar, L-mycarose: AgPF6 as a remarkable activator of 2-deoxythioglycosides. Angewandte Chemie International Edition, 40 (5). pp. 946-949. ISSN 1433-7851

3-dipolar addition

Spiteri, Christian and Sharma, Pallavi and Zhang, Fengzhi and Macdonald, Simon J. F. and Keeling, Steve and Moses, John E. (2010) An improved synthesis of 1,2-benzisoxazoles: TBAF mediated 1,3-dipolar cycloaddition of nitrile oxides and benzyne. Chemical Communications, 46 (8). pp. 1272-1274. ISSN 1359-7345

3-dipolar cycloaddition

Spiteri, Christian and Mason, Christopher and Zhang, Fengzhi and Ritson, Dougal J. and Sharma, Pallavi and Keeling, Steve and Moses, John E. (2010) An efficient entry to 1,2-benzisoxazoles via 1,3-dipolar cycloaddition of in situ generated nitrile oxides and benzyne. Organic and Biomolecular Chemistry Articles, 8 (11). pp. 2537-2542. ISSN 1477-0520

Ab initio and DFT calculations

Kyne, Sara and Schiesser, C. H. (2009) Ab initio studies of carbonyl radical additions to hydrazone systems. Australian Journal of Chemistry, 62 (7). pp. 728-733. ISSN 0004-9425

Ab initio structural calculations

Kyne, S. H. and Schiesser, C. H. and Matsubara, H. (2008) Multiorbital interactions during acyl radical addition reactions involving imines and electron-rich olefins. Journal of Organic Chemistry, 73 (2). pp. 427-434. ISSN 0022-3263

Kyne, S. H. and Schiesser, C. H. and Matsubara, H. (2011) An ab initio and DFT study of radical addition reactions of imidoyl and thioyl radicals to methanimine. Organic and Biomolecular Chemistry, 9 (9). pp. 3217-3224. ISSN 1477-0520

Acetone cyano hydrin

Powell, Kimberley J. and Han, Li-Chen and Sharma, Pallavi and Moses, John E. (2014) Chemoselective palladium-catalyzed cyanation of alkenyl halides. Organic Letters, 16 (8). pp. 2158-2161. ISSN 1523-7060

Acyl ketene

Yang, Eugene G. and Sekar, Karthik and Lear, Martin J. (2013) A macrolactonisation approach to the cembrane carbocycle of bielschowskysin. Tetrahedron Letters, 54 (33). pp. 4406-4408. ISSN 0040-4039

Aldol reaction

Liu, Xiang Hui and Song, Hong Yan and Ma, Xiao Hua and Lear, Martin J. and Chen, Yu Zong (2010) Virtual screening prediction of new potential organocatalysts for direct aldol reactions. Journal of Molecular Catalysis A: Chemical, 319 (1-2). pp. 114-118. ISSN 1381-1169

Alkenyl nitrile

Powell, Kimberley J. and Han, Li-Chen and Sharma, Pallavi and Moses, John E. (2014) Chemoselective palladium-catalyzed cyanation of alkenyl halides. Organic Letters, 16 (8). pp. 2158-2161. ISSN 1523-7060

Amino acids

Ghosh, Shibaji K. and Somanadhan, Brinda and Tan, Kevin S.-W. and Butler, Mark S. and Lear, Martin J. (2012) Absolute configuration and total synthesis of a novel antimalarial lipopeptide by the de novo preparation of chiral nonproteinogenic amino acids. Organic Letters, 14 (6). pp. 1560-1563. ISSN 1523-7060

Anitmalarial agents

Kotturi, Santosh R. and Somanadhan, Brinda and Ch’ng, Jun-Hong and Tan, Kevin S.-W. and Butler, Mark S. and Lear, Martin J. (2014) Diverted total synthesis of falcitidin acyl tetrapeptides as new antimalarial leads. Tetrahedron Letters, 55 (11). pp. 1949-1951. ISSN 0040-4039

Anitproliferative activity

Brunton, V. G. and Lear, M. and Robins, D. J. and Williamson, S. and Workman, P. (1994) Synthesis and antiproliferative activity of tyrphostins containing heteroaromatic moieties. Anti-Cancer Drug Design, 9 (4). pp. 291-309. ISSN 0266-9536

Anti-tumor activities

Yang, Peng-Yu and Liu, Kai and Ngai, Mun Hong and Lear, Martin J. and Wenk, Markus R. and Yao, Shao Q. (2010) Activity-based proteome profiling of potential cellular targets of Orlistat - an FDA-approved drug with anti-tumor activities. Journal of the American Chemical Society, 132 (2). pp. 656-666. ISSN 0002-7863

Antibody labelling

Song, Hong Y. and Ngai, Mun H. and Song, Zhen Y. and MacAry, Paul A. and Hobley, Jonathan and Lear, Martin J. (2009) Practical synthesis of maleimides and coumarin-linked probes for protein and antibody labelling via reduction of native disulfides. Organic & Biomolecular Chemistry, 7 (17). pp. 3400-3406. ISSN 1477-0520

Antiproliferative activity

Brunton, V. G. and Lear, M. and McKeown, P. and Robins, D. J. and Workman, P. (1996) Synthesis and antiproliferative activity of tyrphostins containing quinoline moieties. Anti-Cancer Drug Design, 11 (6). pp. 463-483. ISSN 0266-9536

Aryl halide

Kyne, Sara H. and Percy, Jonathon M. and Pullin, Robert D. C. and Redmond, Joanna M. and Wilson, Peter G. (2011) One-pot near-ambient temperature syntheses of aryl(difluoroenol) derivatives from trifluoroethanol. Organic and Biomolecular Chemistry, 9 (24). pp. 8328-8339. ISSN 14770520

Asymmetric catalysis

Liu, Xiang Hui and Song, Hong Yan and Ma, Xiao Hua and Lear, Martin J. and Chen, Yu Zong (2010) Virtual screening prediction of new potential organocatalysts for direct aldol reactions. Journal of Molecular Catalysis A: Chemical, 319 (1-2). pp. 114-118. ISSN 1381-1169

Asymmetric resolution

Ali, Asif and Wenk, Markus R. and Lear, Martin J. (2009) Total synthesis of a fully lipidated form of phosphatidyl-myo-inositol dimannoside (PIM-2) of Mycobacterium tuberculosis. Tetrahedron Letters, 50 (40). pp. 5664-5666. ISSN 0040-4039

Asymmetric synthesis

Hayashi, Yujiro and Shomura, Hiroki and Xu, Qianqian and Lear, Martin and Sato, Itaru (2015) Asymmetric aldol reaction of α,α-disubstituted acetaldehydes catalyzed by Ddphenylprolinol silyl ether for the construction of quaternary stereogenic centers. European Journal of Organic Chemistry . ISSN 1434-193X (In Press)

Bead microarray

National University of Singapore (2013) A microparticle assembly. WO2013176625 A1.

Benzisoxazole

Spiteri, Christian and Mason, Christopher and Zhang, Fengzhi and Ritson, Dougal J. and Sharma, Pallavi and Keeling, Steve and Moses, John E. (2010) An efficient entry to 1,2-benzisoxazoles via 1,3-dipolar cycloaddition of in situ generated nitrile oxides and benzyne. Organic and Biomolecular Chemistry Articles, 8 (11). pp. 2537-2542. ISSN 1477-0520

Bezisoxazole

Spiteri, Christian and Sharma, Pallavi and Zhang, Fengzhi and Macdonald, Simon J. F. and Keeling, Steve and Moses, John E. (2010) An improved synthesis of 1,2-benzisoxazoles: TBAF mediated 1,3-dipolar cycloaddition of nitrile oxides and benzyne. Chemical Communications, 46 (8). pp. 1272-1274. ISSN 1359-7345

Bielschowskysin

Miao, Ru and Gramani, Subramanian G. and Lear, Martin J. (2009) Stereocontrolled entry to the tricyclo[3.3.0]oxoheptane core of bielschowskysin by a [2+2] cycloaddition of an allene-butenolide. Tetrahedron Letters, 50 (15). pp. 1731-1733. ISSN ISSN

Yang, Eugene G. and Sekar, Karthik and Lear, Martin J. (2013) A macrolactonisation approach to the cembrane carbocycle of bielschowskysin. Tetrahedron Letters, 54 (33). pp. 4406-4408. ISSN 0040-4039

Binding affinity screening

Rodríguez, Abimael D. and Lear, Martin J. and La Clair, James J. (2008) Identification of the binding of sceptrin to MreB via a bidirectional affinity protocol. Journal of the American Chemical Society, 130 (23). pp. 7256-7258. ISSN 0002-7863

Bio-target identification

Lear, Martin (2011) Total synthesis and drug pursuits: laetirobins, lipstatins, platensimycins [ACP Tour, Japan]. In: Asia Core Program Lectureship Tour of Japan, 18-22 Dec 2011, Nagoya, Tokyo, and Tohoku, Japan.

Bio-targeting

Lear, Martin (2010) Exploring the glycolipidome via chemical mimicry. In: EMBO Conference Series: Chemical Biology 2010, 22 - 25 Sep 2010, EMBL Heidelberg, Germany.

Biology

Lear, Martin J. and Salmons, Brian and Gunzburg, Walter H. and Dangerfield, John A. (2009) Singapore R&D and globetrotting. Biotechnology Journal, 4 (2). pp. 179-185. ISSN ISSN

Biomedicine

Lear, Martin J. and Salmons, Brian and Gunzburg, Walter H. and Dangerfield, John A. (2009) Singapore R&D and globetrotting. Biotechnology Journal, 4 (2). pp. 179-185. ISSN ISSN

Biomimetic Synthesis

Lear, Martin (2010) Exploring the glycolipidome via chemical mimicry. In: EMBO Conference Series: Chemical Biology 2010, 22 - 25 Sep 2010, EMBL Heidelberg, Germany.

Lear, Martin and Hirai, Keiichiro and Yamada, Kei and Takahashi, Ryo and Hirama, Masahiro (2014) Total synthesis and biomimetic studies of nine-membered enediynes. In: CRC International Symposium: Synthesis and Applications of Functional Molecules and Materials Utilizing Biomolecules as a Motif, September 30, 2014, Catalytic Research Center, Hokkaido University, Japan.

Sharma, Pallavi and Powell, Kimberley J. and Burnley, James and Moses, John E. and Awaad, Amani S. (2011) Total synthesis of polypropionate derived y-pyrone natural products. Synthesis, 18 . pp. 2865-2892. ISSN 0039-7881

Sharma, Pallavi and Ritson, Dougal J. and Burnley, James and Moses, John E. (2011) A synthetic approach to Kingianin A based upon biosynthetic speculation. Chemical Communications, 47 (38). pp. 10605-10607. ISSN 1359-7345

Biomimetic synthesis

Burnley, James and Ralph, Michael and Sharma, Pallavi and Moses, John E. (2011) Biomimetic electrocyclisation reactions towards polyketide-derived natural products. In: Biomimetic Organic Synthesis. Wiley-VCH, Weinheim. ISBN 9783527325801, 9783527634606

Simon, Oliver and Reux, Bastien and La Clair, James J. and Lear, Martin J. (2010) Total synthesis confirms laetirobin as a formal Diels-Alder adduct. Chemistry - An Asian Journal, 5 (2). pp. 342-351. ISSN 1861-4728

Biomimicry

Lear, Martin (2010) Exploring the glycolipidome via chemical mimicry. In: EMBO Conference Series: Chemical Biology 2010, 22 - 25 Sep 2010, EMBL Heidelberg, Germany.

Lear, Martin and Reux, Bastien and Sekar, Karthik (2012) Chemical synthesis, modification and mimicry of the GPI anchor. In: GPI membrane anchors: the much needed link. Bentham Science Publishers Ltd, pp. 64-82. ISBN 9781608051236

Biomolecular identification

Lear, Martin (2010) Exploring the glycolipidome via chemical mimicry. In: EMBO Conference Series: Chemical Biology 2010, 22 - 25 Sep 2010, EMBL Heidelberg, Germany.

Biosynthesis

Pasari, Sandip and Ismail, Shareef M. and Wenk, Markus R. and Lear, Martin (2015) Preparation of azide biosynthetic surrogates of myo-Inositol. Tetrahedron Letters, 56 (20). pp. 2597-2601. ISSN 0040-4039

Biotarget identification

Rodríguez, Abimael D. and Lear, Martin J. and La Clair, James J. (2008) Identification of the binding of sceptrin to MreB via a bidirectional affinity protocol. Journal of the American Chemical Society, 130 (23). pp. 7256-7258. ISSN 0002-7863

Biotechnology

Lear, Martin J. and Salmons, Brian and Gunzburg, Walter H. and Dangerfield, John A. (2009) Singapore R&D and globetrotting. Biotechnology Journal, 4 (2). pp. 179-185. ISSN ISSN

Bismuth

Eey, Stanley T.-C. and Lear, Martin J. (2010) A bismuth(III)-catalyzed Friedel−Crafts cyclization and stereocontrolled organocatalytic approach to (−)-platensimycin. Organic Letters, 12 (23). pp. 5510-5513. ISSN 1523-7060

Brewster angle microscopy

Gorelik, Sergey and Hongyan, Song and Lear, Martin J. and Hobley, Jonathan (2010) Transient Brewster angle reflectometry of spiropyran monolayers. Photochemical and Photobiological Sciences, 9 (2). pp. 141-151. ISSN 1474-905X

Li, Y. and Song, H. Y. and Lear, M. J. and Gorelik, S. and Tomczak, N. and Hobley, J. (2008) Optical detection of photo-activated protein adsorption using Brewster angle microscopy. In: PhotonicsGlobal@Singapore, 2008. IPGC 2008, 8-11 Dec 2008, Singapore.

Brewster angle reflectometry

Siebenhofer, Bernhard and Gorelik, Sergey and Lear, Martin J. and Song, Hong Yan and Nowak, Christoph and Hobley, Jonathan (2013) Transient absorption spectroscopy on spiropyran monolayers using nanosecond pump–probe Brewster angle reflectometry. Photochemical & Photobiological Sciences, 12 (5). pp. 848-853. ISSN 1474-905X

Bulgecinine

Chavan, Subhash P and Praveen, Cherukupally and Sharma, Pallavi and Kalkote, U. R. (2005) An efficient stereoselective synthesis of (2S,4S,5R)-(-)- and (2R,4R,5S)-(+)-bulgecinine. Tetrahedron Letters, 46 (3). pp. 439-441. ISSN 0040-4039

C-terminal fragment

Fallows, Andrew J. and Singh, Ishwar and Dondi, Ruggero and Cullis, Paul M. and Burley, Glenn A. (2014) Highly efficient synthesis of DNA-binding polyamides using a convergent fragment-based approach. Organic Letters, 16 (17). pp. 4654-4657. ISSN 1523-7060

CCG

Chavan, Subhash P. and Sharma, Pallavi and Sivappa, Rasapalli and Bhadbhade, Mohan B. and Gonnade, Rajesh G. and Kalkote, Uttam R. (2003) Enantioselective synthesis of L-CCG-I. Journal of the American Chemical Society, 68 (17). pp. 6871-6819. ISSN 0002-7863

Cembranes

Miao, Ru and Gramani, Subramanian G. and Lear, Martin J. (2009) Stereocontrolled entry to the tricyclo[3.3.0]oxoheptane core of bielschowskysin by a [2+2] cycloaddition of an allene-butenolide. Tetrahedron Letters, 50 (15). pp. 1731-1733. ISSN ISSN

Chemical characterisation

Lear, Martin J. and Simon, Oliver and Foley, Timothy L. and Burkart, Michael D. and Baiga, Thomas J. and Noel, Joseph P. and DiPasquale, Antonio G. and Rheingold, Arnold L. and La Clair, James J. (2009) Laetirobin from the parasitic growth of Laetiporus sulphurous on Robinia pseudoacacia. Journal of Natural Products, 72 (11). pp. 1980-1987. ISSN 0163-3864

Chemical proteomics

Lear, Martin and Yao, Shao Q. (2010) New directions for old drugs. Project Report. National University of Singapore, Singapore.

Ngai, Mun H. and Yang, Peng-Yu and Liu, Kai and Shen, Yuan and Wenk, Markus R. and Yao, Shao Q. and Lear, Martin J. (2010) Click-based synthesis and proteomic profiling of lipstatin analogues. Chemical Communications, 46 (44). p. 8335. ISSN 1359-7345

Yang, Peng-Yu and Liu, Kai and Ngai, Mun Hong and Lear, Martin J. and Wenk, Markus R. and Yao, Shao Q. (2010) Activity-based proteome profiling of potential cellular targets of Orlistat - an FDA-approved drug with anti-tumor activities. Journal of the American Chemical Society, 132 (2). pp. 656-666. ISSN 0002-7863

Chemical reagent

Kotturi, Santosh R. and Tan, Jason S. and Lear, Martin J. (2009) A mild method for the protection of alcohols using a para-methoxybenzylthio tetrazole (PMB-ST) under dual acid–base activation. Tetrahedron Letters, 50 (37). pp. 5267-5269. ISSN 0040-4039

Chemistry

Lear, Martin J. and Salmons, Brian and Gunzburg, Walter H. and Dangerfield, John A. (2009) Singapore R&D and globetrotting. Biotechnology Journal, 4 (2). pp. 179-185. ISSN ISSN

Chitinophaga

Somanadhan, Brinda and Kotturi, Santosh R. and Yan Leong, Chung and Glover, Robert P. and Huang, Yicun and Flotow, Horst and Buss, Antony D. and Lear, Martin J. and Butler, Mark S. (2013) Isolation and synthesis of falcitidin, a novel myxobacterial-derived acyltetrapeptide with activity against the malaria target falcipain-2. The Journal of Antibiotics, 66 (5). pp. 259-264. ISSN 0021-8820

Click reaction

Sharma, Pallavi and Moses, John E. (2010) Ethynyldiisopropylsilyl: a new alkynylsilane protecting group and click linker. Org. Lett., 12 (12). pp. 2860-2863. ISSN 1523-7060

Click-chemistry

Moorhouse, Adam D. and Spiteri, Christian and Sharma, Pallavi and Zloh, Mire and Moses, John E. (2011) Targeting glycolysis: a fragment based approach towards bifunctional inhibitors of hLDH-5. Chemical Communications, 47 (1). pp. 230-232. ISSN 1359-7345

Computational chemistry

MacDougall, P .E. and Aitken, H. M. and Scammells, P. J. and Kavanagh, Y. and Kyne, S. H. and Schiesser, C. H. (2012) 7-Selenabicyclo2.2.1heptane. Chemical Communications, 48 (73). pp. 9126-9128. ISSN 1359-7345

Conjugate reduction

Eey, Stanley T.-C. and Lear, Martin J. (2010) A bismuth(III)-catalyzed Friedel−Crafts cyclization and stereocontrolled organocatalytic approach to (−)-platensimycin. Organic Letters, 12 (23). pp. 5510-5513. ISSN 1523-7060

Convergent synthetic strategy

Fallows, Andrew J. and Singh, Ishwar and Dondi, Ruggero and Cullis, Paul M. and Burley, Glenn A. (2014) Highly efficient synthesis of DNA-binding polyamides using a convergent fragment-based approach. Organic Letters, 16 (17). pp. 4654-4657. ISSN 1523-7060

Coupling reagents

Fallows, Andrew J. and Singh, Ishwar and Dondi, Ruggero and Cullis, Paul M. and Burley, Glenn A. (2014) Highly efficient synthesis of DNA-binding polyamides using a convergent fragment-based approach. Organic Letters, 16 (17). pp. 4654-4657. ISSN 1523-7060

Cyanation

Powell, Kimberley J. and Han, Li-Chen and Sharma, Pallavi and Moses, John E. (2014) Chemoselective palladium-catalyzed cyanation of alkenyl halides. Organic Letters, 16 (8). pp. 2158-2161. ISSN 1523-7060

Cycloaddition

Miao, Ru and Gramani, Subramanian G. and Lear, Martin J. (2009) Stereocontrolled entry to the tricyclo[3.3.0]oxoheptane core of bielschowskysin by a [2+2] cycloaddition of an allene-butenolide. Tetrahedron Letters, 50 (15). pp. 1731-1733. ISSN ISSN

Cycloalkenes

Nelson, D. J. and Ashworth, I. W. and Hillier, I. H. and Kyne, S. H. and Pandian, S. and Parkinson, J. A. and Percy, J. M. and Rinaudo, G. and Vincent, M. A. (2011) Why is RCM favoured over dimerisation? Predicting and estimating thermodynamic effective molarities by solution experiments and electronic structure calculations. Chemistry - A European Journal, 17 (46). pp. 13087-13094. ISSN 0947-6539

Cycloaromatization

Hirama, Masahiro and Akiyama, Kimio and Das, Parthasarathi and Mita, Takashi and Lear, Martin J. and Iida, Kyo-ichiro and Sato, Itaru and Yoshimura, Fumihiko and Usuki, Toyonobu and Tero-Kubota, Shozo (2006) Direct observation of ESR spectra of bicyclic nine-membered enediynes at ambient temperature. Heterocycles, 69 (1). pp. 83-89. ISSN 0385-5414

DNA cleavage

Kobayashi, Shoji and Ashizawa, Shukuko and Takahashi, Yusuke and Sugiura, Yukio and Nagaoka, Makoto and Lear, Martin J. and Hirama, Masahiro (2001) The first total synthesis of N1999-A2: absolute stereochemistry and stereochemical implications into DNA cleavage. Journal of the American Chemical Society, 123 (45). pp. 11294-11295. ISSN 0002-7863

DNA sequence

Cousins, Alex R. O. and Ritson, Dougal and Sharma, Pallavi and Stevens, Malcolm F. G. and Moses, John E. and Searle, Mark S. (2014) Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences. Chemical Communications, 50 . pp. 15202-15205. ISSN 1359-7345

DNA-binding polyamides

Fallows, Andrew J. and Singh, Ishwar and Dondi, Ruggero and Cullis, Paul M. and Burley, Glenn A. (2014) Highly efficient synthesis of DNA-binding polyamides using a convergent fragment-based approach. Organic Letters, 16 (17). pp. 4654-4657. ISSN 1523-7060

Dehydrofluorination/zincation

Kyne, Sara H. and Percy, Jonathon M. and Pullin, Robert D. C. and Redmond, Joanna M. and Wilson, Peter G. (2011) One-pot near-ambient temperature syntheses of aryl(difluoroenol) derivatives from trifluoroethanol. Organic and Biomolecular Chemistry, 9 (24). pp. 8328-8339. ISSN 14770520

Density functional theory

Kyne, S. H. and Miles, J. A. L. and Percy, J. M. and Singh, K. (2012) Executing and rationalizing the synthesis of a difluorinated analogue of a ring-expanded calystegine B2. Journal of Organic Chemistry, 77 (2). pp. 991-998. ISSN 0022-3263

Kyne, S. H. and Schiesser, C. H. and Matsubara, H. (2008) Multiorbital interactions during acyl radical addition reactions involving imines and electron-rich olefins. Journal of Organic Chemistry, 73 (2). pp. 427-434. ISSN 0022-3263

Kyne, S. H. and Schiesser, C. H. and Matsubara, H. (2011) An ab initio and DFT study of radical addition reactions of imidoyl and thioyl radicals to methanimine. Organic and Biomolecular Chemistry, 9 (9). pp. 3217-3224. ISSN 1477-0520

Kyne, Sara and Schiesser, Carl H. and Matsubara, Hiroshi (2007) Multi-component orbital interactions during oxyacyl radical addition reactions involving imines and electron-rich olefins. Organic & Biomolecular Chemistry, 5 (24). pp. 3938-3943. ISSN 1477-0520

Kyne, Sara H. and Percy, Jonathon M. and Pullin, Robert D. C. and Redmond, Joanna M. and Wilson, Peter G. (2011) One-pot near-ambient temperature syntheses of aryl(difluoroenol) derivatives from trifluoroethanol. Organic and Biomolecular Chemistry, 9 (24). pp. 8328-8339. ISSN 14770520

Density functional theory calculations

Kyne, Sara H. and Aitken, Heather M. and Schiesser, Carl H. and Lacote, Emmanuel and Malacria, Max and Ollivier, Cyril and Fensterbank, Louis (2011) Intramolecular homolytic substitution of sulfinates and sulfinamides: a computational study. Organic and Biomolecular Chemistry, 9 (9). pp. 3331-3337. ISSN 1477-0520

Deoxy sugars

Pasari, Sandip and Ismail, Shareef M. and Wenk, Markus R. and Lear, Martin (2015) Preparation of azide biosynthetic surrogates of myo-Inositol. Tetrahedron Letters, 56 (20). pp. 2597-2601. ISSN 0040-4039

Detection of binding events

National University of Singapore (2013) A microparticle assembly. WO2013176625 A1.

Diels-Alder

Chavan, Subhash P. and Sharma, Pallavi and Ramakrishna, G. and Thakkar, Mahesh (2003) Iodine as an efficient catalyst in ionic Diels–Alder reactions of α,β-unsaturated acetals. Tetrahedron Letters, 44 (14). pp. 3001-3003. ISSN 0040-4039

Moore, Jonathan C. and Davies, E. Stephen and Walsh, Darren A. and Sharma, Pallavi and Moses, John E. (2014) Formal synthesis of kingianin A based upon a novel electrochemically-induced radical cation Diels–Alder reaction. Chemical communications, 50 (83). pp. 12523-12525. ISSN 1359-7345

Simon, Oliver and Reux, Bastien and La Clair, James J. and Lear, Martin J. (2010) Total synthesis confirms laetirobin as a formal Diels-Alder adduct. Chemistry - An Asian Journal, 5 (2). pp. 342-351. ISSN 1861-4728

Drug discovery

Lear, Martin (2012) Total synthesis and drug pursuits: laetirobins, lipstatins, platensimycins. In: ZiNG Natural Products Conference 2012: Natural Products Synthesis and Biosynthesis, 10 - 13 February 2012, Lanzarote, Spain.

Lear, Martin (2011) Total synthesis and drug pursuits: laetirobins, lipstatins, platensimycins [ACP Tour, Japan]. In: Asia Core Program Lectureship Tour of Japan, 18-22 Dec 2011, Nagoya, Tokyo, and Tohoku, Japan.

Drug labelling

National University of Singapore (2012) Synthesis and use of fluorophore-tagged antimalarials. US20120100555 A1.

Drug off-targets

Yang, Peng-Yu and Liu, Kai and Ngai, Mun Hong and Lear, Martin J. and Wenk, Markus R. and Yao, Shao Q. (2010) Activity-based proteome profiling of potential cellular targets of Orlistat - an FDA-approved drug with anti-tumor activities. Journal of the American Chemical Society, 132 (2). pp. 656-666. ISSN 0002-7863

Drug resistance

National University of Singapore (2012) Synthesis and use of fluorophore-tagged antimalarials. US20120100555 A1.

Electrochemistry

Moore, Jonathan C. and Davies, E. Stephen and Walsh, Darren A. and Sharma, Pallavi and Moses, John E. (2014) Formal synthesis of kingianin A based upon a novel electrochemically-induced radical cation Diels–Alder reaction. Chemical communications, 50 (83). pp. 12523-12525. ISSN 1359-7345

Electrocyclisation

Burnley, James and Ralph, Michael and Sharma, Pallavi and Moses, John E. (2011) Biomimetic electrocyclisation reactions towards polyketide-derived natural products. In: Biomimetic Organic Synthesis. Wiley-VCH, Weinheim. ISBN 9783527325801, 9783527634606

Electrocycllisation

Sharma, Pallavi and Powell, Kimberley J. and Burnley, James and Moses, John E. and Awaad, Amani S. (2011) Total synthesis of polypropionate derived y-pyrone natural products. Synthesis, 18 . pp. 2865-2892. ISSN 0039-7881

Enantiodivergent

Ghosh, Shibaji K. and Butler, Mark S. and Lear, Martin J. (2012) Synthesis of 2-C-methylerythritols and 2-C-methylthreitols via enantiodivergent Sharpless dihydroxylation of trisubstituted olefins. Tetrahedron Letters, 53 (22). pp. 2706-2708. ISSN 0040-4039

Epoxidation reaction

Kyne, S. H. and Miles, J. A. L. and Percy, J. M. and Singh, K. (2012) Executing and rationalizing the synthesis of a difluorinated analogue of a ring-expanded calystegine B2. Journal of Organic Chemistry, 77 (2). pp. 991-998. ISSN 0022-3263

Erythrulose

Kobayashi, Shoji and Das, Parthasarathi and Wang, Guang Xing and Mita, Takashi and Lear, Martin J. and Hirama, Masahiro (2002) Diastereoselective additions of ethynyl Grignard reagent to erythrulose derivatives. Chemistry Letters, 31 (3). pp. 300-301. ISSN 0366-7022

Falcitidin

Kotturi, Santosh R. and Somanadhan, Brinda and Ch’ng, Jun-Hong and Tan, Kevin S.-W. and Butler, Mark S. and Lear, Martin J. (2014) Diverted total synthesis of falcitidin acyl tetrapeptides as new antimalarial leads. Tetrahedron Letters, 55 (11). pp. 1949-1951. ISSN 0040-4039

Fatty acid synthase

Ngai, Mun H. and Yang, Peng-Yu and Liu, Kai and Shen, Yuan and Wenk, Markus R. and Yao, Shao Q. and Lear, Martin J. (2010) Click-based synthesis and proteomic profiling of lipstatin analogues. Chemical Communications, 46 (44). p. 8335. ISSN 1359-7345

Fluorescent immuno-affinity label

Rodríguez, Abimael D. and Lear, Martin J. and La Clair, James J. (2008) Identification of the binding of sceptrin to MreB via a bidirectional affinity protocol. Journal of the American Chemical Society, 130 (23). pp. 7256-7258. ISSN 0002-7863

Fluorescent labels

National University of Singapore (2012) Synthesis and use of fluorophore-tagged antimalarials. US20120100555 A1.

Fluorescent sensing

National University of Singapore (2013) A microparticle assembly. WO2013176625 A1.

Fluorescent-labeled probes

Song, Hong Y. and Ngai, Mun H. and Song, Zhen Y. and MacAry, Paul A. and Hobley, Jonathan and Lear, Martin J. (2009) Practical synthesis of maleimides and coumarin-linked probes for protein and antibody labelling via reduction of native disulfides. Organic & Biomolecular Chemistry, 7 (17). pp. 3400-3406. ISSN 1477-0520

Free radical carbonylation

Kyne, S. H. and Lin, C. Y. and Ryu, I. and Coote, M. L. and Schiesser, C. H. (2010) First determination of the rate constant for ring-closure of an azahexenoyl radical: 6-aza-7-ethyl-5-hexenoyl. Chemical Communications, 46 (35). pp. 6521-6523. ISSN 1359-7345

Free radical chemistry

Kyne, Sara and Aitken, Hesther M. and Horvat, Sonia M. and Lin, Ching Yeh and Coote, Michelle L. and Schiesser, Carl H. (2012) Homolytic substitution chemistry: from James Franz to antihypertensives. ChemInform, 43 (30). pp. 927-928. ISSN 0931-7597

Kyne, Sara and Schiesser, Carl H. (2012) Intramolecular homolytic substitutions in synthesis. In: Encyclopedia of Radicals in Chemistry, Biology and Materials. John Wiley and Sons, Ltd., Chichester, UK, pp. 629-654. ISBN 9781119953678

Friedel-Crafts

Eey, Stanley T.-C. and Lear, Martin J. (2014) Total synthesis of (−)-platensimycin by advancing oxocarbenium- and iminium-mediated catalytic methods. Chemistry - A European Journal, 20 (36). pp. 11556-11573. ISSN 0947-6539

Furanocembranoid

Yang, Eugene G. and Sekar, Karthik and Lear, Martin J. (2013) A macrolactonisation approach to the cembrane carbocycle of bielschowskysin. Tetrahedron Letters, 54 (33). pp. 4406-4408. ISSN 0040-4039

G-quadruplex

Cousins, Alex R. O. and Ritson, Dougal and Sharma, Pallavi and Stevens, Malcolm F. G. and Moses, John E. and Searle, Mark S. (2014) Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences. Chemical Communications, 50 . pp. 15202-15205. ISSN 1359-7345

Gas chromatography

Dharmawan, Jorry and Kasapis, Stefan and Sriramula, Praveena and Lear, Martin J. and Curran, Philip (2009) Evaluation of aroma-active compounds in Pontianak Orange Peel Oil (Citrus nobilis Lour. Var.microcarpaHassk.) by gas chromatography−olfactometry, aroma reconstitution, and omission test. Journal of Agricultural and Food Chemistry, 57 (1). pp. 239-244. ISSN 0021-8561

Globalisation

Lear, Martin J. and Salmons, Brian and Gunzburg, Walter H. and Dangerfield, John A. (2009) Singapore R&D and globetrotting. Biotechnology Journal, 4 (2). pp. 179-185. ISSN ISSN

Glycobiology

Lear, Martin and Reux, Bastien and Sekar, Karthik (2012) Chemical synthesis, modification and mimicry of the GPI anchor. In: GPI membrane anchors: the much needed link. Bentham Science Publishers Ltd, pp. 64-82. ISBN 9781608051236

Glycolipids

Ali, Asif and Wenk, Markus R. and Lear, Martin J. (2009) Total synthesis of a fully lipidated form of phosphatidyl-myo-inositol dimannoside (PIM-2) of Mycobacterium tuberculosis. Tetrahedron Letters, 50 (40). pp. 5664-5666. ISSN 0040-4039

Lear, Martin and Reux, Bastien and Sekar, Karthik (2012) Chemical synthesis, modification and mimicry of the GPI anchor. In: GPI membrane anchors: the much needed link. Bentham Science Publishers Ltd, pp. 64-82. ISBN 9781608051236

Pasari, Sandip and Ismail, Shareef M. and Wenk, Markus R. and Lear, Martin (2015) Preparation of azide biosynthetic surrogates of myo-Inositol. Tetrahedron Letters, 56 (20). pp. 2597-2601. ISSN 0040-4039

Glycosylation

Ohashi, Isao and Lear, Martin J. and Yoshimura, Fumihiko and Hirama, Masahiro (2004) Use of polystyrene-supported DBU in the synthesis and α-selective glycosylation study of the unstable Schmidt donor of L-kedarosamine. Organic Letters, 6 (5). pp. 719-722. ISSN 1523-7060

Grignard addition

Kobayashi, Shoji and Das, Parthasarathi and Wang, Guang Xing and Mita, Takashi and Lear, Martin J. and Hirama, Masahiro (2002) Diastereoselective additions of ethynyl Grignard reagent to erythrulose derivatives. Chemistry Letters, 31 (3). pp. 300-301. ISSN 0366-7022

Hairpin pyrrole-imidazole polyamides

Fallows, Andrew J. and Singh, Ishwar and Dondi, Ruggero and Cullis, Paul M. and Burley, Glenn A. (2014) Highly efficient synthesis of DNA-binding polyamides using a convergent fragment-based approach. Organic Letters, 16 (17). pp. 4654-4657. ISSN 1523-7060

Homogenous catalysis

Nelson, D. J. and Ashworth, I. W. and Hillier, I. H. and Kyne, S. H. and Pandian, S. and Parkinson, J. A. and Percy, J. M. and Rinaudo, G. and Vincent, M. A. (2011) Why is RCM favoured over dimerisation? Predicting and estimating thermodynamic effective molarities by solution experiments and electronic structure calculations. Chemistry - A European Journal, 17 (46). pp. 13087-13094. ISSN 0947-6539

Homolytic substitution

Kyne, Sara and Aitken, Hesther M. and Horvat, Sonia M. and Lin, Ching Yeh and Coote, Michelle L. and Schiesser, Carl H. (2012) Homolytic substitution chemistry: from James Franz to antihypertensives. ChemInform, 43 (30). pp. 927-928. ISSN 0931-7597

Kyne, Sara and Schiesser, Carl H. (2012) Intramolecular homolytic substitutions in synthesis. In: Encyclopedia of Radicals in Chemistry, Biology and Materials. John Wiley and Sons, Ltd., Chichester, UK, pp. 629-654. ISBN 9781119953678

Kyne, Sara H. and Aitken, Heather M. and Schiesser, Carl H. and Lacote, Emmanuel and Malacria, Max and Ollivier, Cyril and Fensterbank, Louis (2011) Intramolecular homolytic substitution of sulfinates and sulfinamides: a computational study. Organic and Biomolecular Chemistry, 9 (9). pp. 3331-3337. ISSN 1477-0520

Hydrazone

Kyne, Sara and Schiesser, C. H. (2009) Ab initio studies of carbonyl radical additions to hydrazone systems. Australian Journal of Chemistry, 62 (7). pp. 728-733. ISSN 0004-9425

Imine

Kyne, S. H. and Schiesser, C. H. and Matsubara, H. (2008) Multiorbital interactions during acyl radical addition reactions involving imines and electron-rich olefins. Journal of Organic Chemistry, 73 (2). pp. 427-434. ISSN 0022-3263

Kyne, Sara and Schiesser, Carl H. and Matsubara, Hiroshi (2007) Multi-component orbital interactions during oxyacyl radical addition reactions involving imines and electron-rich olefins. Organic & Biomolecular Chemistry, 5 (24). pp. 3938-3943. ISSN 1477-0520

Immobilisation chemistry

Li, Y. and Song, H. Y. and Lear, M. J. and Gorelik, S. and Tomczak, N. and Hobley, J. (2008) Optical detection of photo-activated protein adsorption using Brewster angle microscopy. In: PhotonicsGlobal@Singapore, 2008. IPGC 2008, 8-11 Dec 2008, Singapore.

Immuno-affinity screening

Lear, Martin J. and Simon, Oliver and Foley, Timothy L. and Burkart, Michael D. and Baiga, Thomas J. and Noel, Joseph P. and DiPasquale, Antonio G. and Rheingold, Arnold L. and La Clair, James J. (2009) Laetirobin from the parasitic growth of Laetiporus sulphurous on Robinia pseudoacacia. Journal of Natural Products, 72 (11). pp. 1980-1987. ISSN 0163-3864

Inositol

Pasari, Sandip and Ismail, Shareef M. and Wenk, Markus R. and Lear, Martin (2015) Preparation of azide biosynthetic surrogates of myo-Inositol. Tetrahedron Letters, 56 (20). pp. 2597-2601. ISSN 0040-4039

Intermolecular radical addition

Kyne, S. H. and Schiesser, C. H. and Matsubara, H. (2008) Multiorbital interactions during acyl radical addition reactions involving imines and electron-rich olefins. Journal of Organic Chemistry, 73 (2). pp. 427-434. ISSN 0022-3263

Kyne, S. H. and Schiesser, C. H. and Matsubara, H. (2011) An ab initio and DFT study of radical addition reactions of imidoyl and thioyl radicals to methanimine. Organic and Biomolecular Chemistry, 9 (9). pp. 3217-3224. ISSN 1477-0520

Kyne, Sara and Schiesser, C. H. (2009) Ab initio studies of carbonyl radical additions to hydrazone systems. Australian Journal of Chemistry, 62 (7). pp. 728-733. ISSN 0004-9425

Kyne, Sara and Schiesser, Carl H. and Matsubara, Hiroshi (2007) Multi-component orbital interactions during oxyacyl radical addition reactions involving imines and electron-rich olefins. Organic & Biomolecular Chemistry, 5 (24). pp. 3938-3943. ISSN 1477-0520

Intramolecular

Kyne, Sara and Schiesser, Carl H. (2012) Intramolecular homolytic substitutions in synthesis. In: Encyclopedia of Radicals in Chemistry, Biology and Materials. John Wiley and Sons, Ltd., Chichester, UK, pp. 629-654. ISBN 9781119953678

Intramolecular cyclisation

Kyne, S. H. and Lin, C. Y. and Ryu, I. and Coote, M. L. and Schiesser, C. H. (2010) First determination of the rate constant for ring-closure of an azahexenoyl radical: 6-aza-7-ethyl-5-hexenoyl. Chemical Communications, 46 (35). pp. 6521-6523. ISSN 1359-7345

Isotope labelling

Das, Parthasarathi and Mita, Takashi and Lear, Martin and Hirama, Masahiro (2002) Synthesis of 13C-labelled, bicyclic mimetics of natural enediynes. Chemical Communications (22). pp. 2624-2625. ISSN 1359-7345

Usuki, Toyonobu and Mita, Takashi and Lear, Martin J. and Das, Parthasarathi and Yoshimura, Fumihiko and Inoue, Masayuki and Hirama, Masahiro and Akiyama, Kimio and Tero-Kubota, Shozo (2004) Spin trapping of 13C-labeled p-benzynes generated by Masamune–Bergman cyclization of bicyclic nine-membered enediynes. Angewandte Chemie International Edition, 43 (39). pp. 5249-5253. ISSN 1433-7851

Kinetics

MacDougall, P .E. and Aitken, H. M. and Scammells, P. J. and Kavanagh, Y. and Kyne, S. H. and Schiesser, C. H. (2012) 7-Selenabicyclo2.2.1heptane. Chemical Communications, 48 (73). pp. 9126-9128. ISSN 1359-7345

Kingianin A

Moore, Jonathan C. and Davies, E. Stephen and Walsh, Darren A. and Sharma, Pallavi and Moses, John E. (2014) Formal synthesis of kingianin A based upon a novel electrochemically-induced radical cation Diels–Alder reaction. Chemical communications, 50 (83). pp. 12523-12525. ISSN 1359-7345

Knoevenagel reaction

Brunton, V. G. and Lear, M. and McKeown, P. and Robins, D. J. and Workman, P. (1996) Synthesis and antiproliferative activity of tyrphostins containing quinoline moieties. Anti-Cancer Drug Design, 11 (6). pp. 463-483. ISSN 0266-9536

Brunton, V. G. and Lear, M. and Robins, D. J. and Williamson, S. and Workman, P. (1994) Synthesis and antiproliferative activity of tyrphostins containing heteroaromatic moieties. Anti-Cancer Drug Design, 9 (4). pp. 291-309. ISSN 0266-9536

Lactate dehydrogenase

Moorhouse, Adam D. and Spiteri, Christian and Sharma, Pallavi and Zloh, Mire and Moses, John E. (2011) Targeting glycolysis: a fragment based approach towards bifunctional inhibitors of hLDH-5. Chemical Communications, 47 (1). pp. 230-232. ISSN 1359-7345

Laser ablation

Lear, Martin and Hobley, Jonathan (2008) You make it, I break it. COSMOS, 04 (01). pp. 99-129. ISSN 0219-6077

Lead discovery

Lear, Martin J. and Simon, Oliver and Foley, Timothy L. and Burkart, Michael D. and Baiga, Thomas J. and Noel, Joseph P. and DiPasquale, Antonio G. and Rheingold, Arnold L. and La Clair, James J. (2009) Laetirobin from the parasitic growth of Laetiporus sulphurous on Robinia pseudoacacia. Journal of Natural Products, 72 (11). pp. 1980-1987. ISSN 0163-3864

MIRC

Chavan, Subhash P. and Sharma, Pallavi and Sivappa, Rasapalli and Bhadbhade, Mohan B. and Gonnade, Rajesh G. and Kalkote, Uttam R. (2003) Enantioselective synthesis of L-CCG-I. Journal of the American Chemical Society, 68 (17). pp. 6871-6819. ISSN 0002-7863

Macrocyclisation

Yang, Eugene G. and Sekar, Karthik and Lear, Martin J. (2013) A macrolactonisation approach to the cembrane carbocycle of bielschowskysin. Tetrahedron Letters, 54 (33). pp. 4406-4408. ISSN 0040-4039

Malaria

Ghosh, Shibaji K. and Butler, Mark S. and Lear, Martin J. (2012) Synthesis of 2-C-methylerythritols and 2-C-methylthreitols via enantiodivergent Sharpless dihydroxylation of trisubstituted olefins. Tetrahedron Letters, 53 (22). pp. 2706-2708. ISSN 0040-4039

Malaria detection

National University of Singapore (2012) Synthesis and use of fluorophore-tagged antimalarials. US20120100555 A1.

Maleimide reagents

Song, Hong Y. and Ngai, Mun H. and Song, Zhen Y. and MacAry, Paul A. and Hobley, Jonathan and Lear, Martin J. (2009) Practical synthesis of maleimides and coumarin-linked probes for protein and antibody labelling via reduction of native disulfides. Organic & Biomolecular Chemistry, 7 (17). pp. 3400-3406. ISSN 1477-0520

Mechanism

Hirama, Masahiro and Akiyama, Kimio and Das, Parthasarathi and Mita, Takashi and Lear, Martin J. and Iida, Kyo-ichiro and Sato, Itaru and Yoshimura, Fumihiko and Usuki, Toyonobu and Tero-Kubota, Shozo (2006) Direct observation of ESR spectra of bicyclic nine-membered enediynes at ambient temperature. Heterocycles, 69 (1). pp. 83-89. ISSN 0385-5414

Usuki, Toyonobu and Mita, Takashi and Lear, Martin J. and Das, Parthasarathi and Yoshimura, Fumihiko and Inoue, Masayuki and Hirama, Masahiro and Akiyama, Kimio and Tero-Kubota, Shozo (2004) Spin trapping of 13C-labeled p-benzynes generated by Masamune–Bergman cyclization of bicyclic nine-membered enediynes. Angewandte Chemie International Edition, 43 (39). pp. 5249-5253. ISSN 1433-7851

Merocyanine

Siebenhofer, Bernhard and Gorelik, Sergey and Lear, Martin J. and Song, Hong Yan and Nowak, Christoph and Hobley, Jonathan (2013) Transient absorption spectroscopy on spiropyran monolayers using nanosecond pump–probe Brewster angle reflectometry. Photochemical & Photobiological Sciences, 12 (5). pp. 848-853. ISSN 1474-905X

Merocyanines

Hobley, Jonathan and Lear, Martin and Fukumura, Hiroshi (2003) Photo-switching spiropyrans and related compounds. In: Photochemistry of organic molecules in isotropic and anisotropic media. Marcel Dekker, Inc, pp. 353-404. ISBN 9780824708832, 9780203014202

Metathesis reactions

Nelson, D. J. and Ashworth, I. W. and Hillier, I. H. and Kyne, S. H. and Pandian, S. and Parkinson, J. A. and Percy, J. M. and Rinaudo, G. and Vincent, M. A. (2011) Why is RCM favoured over dimerisation? Predicting and estimating thermodynamic effective molarities by solution experiments and electronic structure calculations. Chemistry - A European Journal, 17 (46). pp. 13087-13094. ISSN 0947-6539

Mevalonate

Ghosh, Shibaji K. and Butler, Mark S. and Lear, Martin J. (2012) Synthesis of 2-C-methylerythritols and 2-C-methylthreitols via enantiodivergent Sharpless dihydroxylation of trisubstituted olefins. Tetrahedron Letters, 53 (22). pp. 2706-2708. ISSN 0040-4039

Michael addition

Lear, Martin J. and Hayashi, Yujiro (2013) Remote 1,6-stereocontrol by iminium-mediated organocatalytic events. ChemCatChem, 5 (12). pp. 3499-3501. ISSN 1867-3880

Mode-of-action

Lear, Martin (2013) Synthetic ventures into the platensimycins, bielschowskysins, lipstatins, and enediynes. In: Lecture Tour, July 2013, RIKEN, Waseda University, Keio University, Sophia University, Japan.

N-terminal fragment

Fallows, Andrew J. and Singh, Ishwar and Dondi, Ruggero and Cullis, Paul M. and Burley, Glenn A. (2014) Highly efficient synthesis of DNA-binding polyamides using a convergent fragment-based approach. Organic Letters, 16 (17). pp. 4654-4657. ISSN 1523-7060

Natural Product

Ghosh, Shibaji K. and Somanadhan, Brinda and Tan, Kevin S.-W. and Butler, Mark S. and Lear, Martin J. (2012) Absolute configuration and total synthesis of a novel antimalarial lipopeptide by the de novo preparation of chiral nonproteinogenic amino acids. Organic Letters, 14 (6). pp. 1560-1563. ISSN 1523-7060

Moore, Jonathan C. and Davies, E. Stephen and Walsh, Darren A. and Sharma, Pallavi and Moses, John E. (2014) Formal synthesis of kingianin A based upon a novel electrochemically-induced radical cation Diels–Alder reaction. Chemical communications, 50 (83). pp. 12523-12525. ISSN 1359-7345

Natural Products

Burnley, James and Ralph, Michael and Sharma, Pallavi and Moses, John E. (2011) Biomimetic electrocyclisation reactions towards polyketide-derived natural products. In: Biomimetic Organic Synthesis. Wiley-VCH, Weinheim. ISBN 9783527325801, 9783527634606

Natural enediynes

Das, Parthasarathi and Mita, Takashi and Lear, Martin and Hirama, Masahiro (2002) Synthesis of 13C-labelled, bicyclic mimetics of natural enediynes. Chemical Communications (22). pp. 2624-2625. ISSN 1359-7345

Hirama, Masahiro and Akiyama, Kimio and Das, Parthasarathi and Mita, Takashi and Lear, Martin J. and Iida, Kyo-ichiro and Sato, Itaru and Yoshimura, Fumihiko and Usuki, Toyonobu and Tero-Kubota, Shozo (2006) Direct observation of ESR spectra of bicyclic nine-membered enediynes at ambient temperature. Heterocycles, 69 (1). pp. 83-89. ISSN 0385-5414

Kobayashi, Shoji and Ashizawa, Shukuko and Takahashi, Yusuke and Sugiura, Yukio and Nagaoka, Makoto and Lear, Martin J. and Hirama, Masahiro (2001) The first total synthesis of N1999-A2: absolute stereochemistry and stereochemical implications into DNA cleavage. Journal of the American Chemical Society, 123 (45). pp. 11294-11295. ISSN 0002-7863

Koyama, Yasuhito and Lear, Martin J. and Yoshimura, Fumihiko and Ohashi, Isao and Mashimo, Tomoko and Hirama, Masahiro (2005) Efficient construction of the kedarcidin chromophore ansamacrolide. Organic Letters, 7 (2). pp. 267-270. ISSN 1523-7060

Lear, Martin (2015) Routes to nine-membered enediynes: not such a walk in the park. In: 64th Gordon Research Conference (GRC) on Natural Products 2015, July 26-31, 2015, Proctor Academy, Andover, NH, USA.

Lear, Martin and Hirai, Keiichiro and Yamada, Kei and Takahashi, Ryo and Hirama, Masahiro (2014) Total synthesis and biomimetic studies of nine-membered enediynes. In: CRC International Symposium: Synthesis and Applications of Functional Molecules and Materials Utilizing Biomolecules as a Motif, September 30, 2014, Catalytic Research Center, Hokkaido University, Japan.

Lear, Martin J. and Hirama, Masahiro (1999) Convenient route to derivatives of the 2-deoxysugar subunits of the kedarcidin chromophore: L-mycarose and L-kedarosamine. Tetrahedron Letters, 40 (26). pp. 4897-4900. ISSN 0040-4039

Lear, Martin J. and Yoshimura, Fumihiko and Hirama, Masahiro (2001) A direct and efficient α-selective glycosylation protocol for the kedarcidin sugar, L-mycarose: AgPF6 as a remarkable activator of 2-deoxythioglycosides. Angewandte Chemie International Edition, 40 (5). pp. 946-949. ISSN 1433-7851

Ohashi, Isao and Lear, Martin J. and Yoshimura, Fumihiko and Hirama, Masahiro (2004) Use of polystyrene-supported DBU in the synthesis and α-selective glycosylation study of the unstable Schmidt donor of L-kedarosamine. Organic Letters, 6 (5). pp. 719-722. ISSN 1523-7060

Usuki, Toyonobu and Mita, Takashi and Lear, Martin J. and Das, Parthasarathi and Yoshimura, Fumihiko and Inoue, Masayuki and Hirama, Masahiro and Akiyama, Kimio and Tero-Kubota, Shozo (2004) Spin trapping of 13C-labeled p-benzynes generated by Masamune–Bergman cyclization of bicyclic nine-membered enediynes. Angewandte Chemie International Edition, 43 (39). pp. 5249-5253. ISSN 1433-7851

Yoshimura, Fumihiko and Lear, Martin J. and Ohashi, Isao and Koyama, Yasuhito and Hirama, Masahiro (2007) Synthesis of the entire carbon framework of the kedarcidin chromophore aglycon. Chemical Communications (29). p. 3057. ISSN 1359-7345

Natural product

Dharmawan, Jorry and Kasapis, Stefan and Sriramula, Praveena and Lear, Martin J. and Curran, Philip (2009) Evaluation of aroma-active compounds in Pontianak Orange Peel Oil (Citrus nobilis Lour. Var.microcarpaHassk.) by gas chromatography−olfactometry, aroma reconstitution, and omission test. Journal of Agricultural and Food Chemistry, 57 (1). pp. 239-244. ISSN 0021-8561

Eey, Stanley T.-C. and Lear, Martin J. (2010) A bismuth(III)-catalyzed Friedel−Crafts cyclization and stereocontrolled organocatalytic approach to (−)-platensimycin. Organic Letters, 12 (23). pp. 5510-5513. ISSN 1523-7060

Ngai, Mun H. and Yang, Peng-Yu and Liu, Kai and Shen, Yuan and Wenk, Markus R. and Yao, Shao Q. and Lear, Martin J. (2010) Click-based synthesis and proteomic profiling of lipstatin analogues. Chemical Communications, 46 (44). p. 8335. ISSN 1359-7345

Simon, Oliver and Reux, Bastien and La Clair, James J. and Lear, Martin J. (2010) Total synthesis confirms laetirobin as a formal Diels-Alder adduct. Chemistry - An Asian Journal, 5 (2). pp. 342-351. ISSN 1861-4728

Natural products

Kotturi, Santosh R. and Somanadhan, Brinda and Ch’ng, Jun-Hong and Tan, Kevin S.-W. and Butler, Mark S. and Lear, Martin J. (2014) Diverted total synthesis of falcitidin acyl tetrapeptides as new antimalarial leads. Tetrahedron Letters, 55 (11). pp. 1949-1951. ISSN 0040-4039

Lear, Martin (2010) Exploring the glycolipidome via chemical mimicry. In: EMBO Conference Series: Chemical Biology 2010, 22 - 25 Sep 2010, EMBL Heidelberg, Germany.

Lear, Martin (2010) One small step for synthesis; one giant leap for total synthesis. In: 59th Natural Products Gordon Research Conference, July 25-30, 2010, Tilton, NH, USA.

Lear, Martin (2013) Synthetic ventures into the platensimycins, bielschowskysins, lipstatins, and enediynes. In: Lecture Tour, July 2013, RIKEN, Waseda University, Keio University, Sophia University, Japan.

Lear, Martin (2011) Total synthesis and drug pursuits: laetirobins, lipstatins, platensimycins [ACP Tour, Japan]. In: Asia Core Program Lectureship Tour of Japan, 18-22 Dec 2011, Nagoya, Tokyo, and Tohoku, Japan.

Lear, Martin (2012) Total synthesis and drug pursuits: the good, the bad, and the ugly. In: UK and European Lecture Tour, May - July 2012, St Andrews, Edinburgh, and Glasgow Universities (UK), EPFL (Lausanne, Switzerland), University of Strasbourg (France).

Lear, Martin J. and Simon, Oliver and Foley, Timothy L. and Burkart, Michael D. and Baiga, Thomas J. and Noel, Joseph P. and DiPasquale, Antonio G. and Rheingold, Arnold L. and La Clair, James J. (2009) Laetirobin from the parasitic growth of Laetiporus sulphurous on Robinia pseudoacacia. Journal of Natural Products, 72 (11). pp. 1980-1987. ISSN 0163-3864

Rodríguez, Abimael D. and Lear, Martin J. and La Clair, James J. (2008) Identification of the binding of sceptrin to MreB via a bidirectional affinity protocol. Journal of the American Chemical Society, 130 (23). pp. 7256-7258. ISSN 0002-7863

Negishi coupling

Kyne, Sara H. and Percy, Jonathon M. and Pullin, Robert D. C. and Redmond, Joanna M. and Wilson, Peter G. (2011) One-pot near-ambient temperature syntheses of aryl(difluoroenol) derivatives from trifluoroethanol. Organic and Biomolecular Chemistry, 9 (24). pp. 8328-8339. ISSN 14770520

Odor activity value

Dharmawan, Jorry and Kasapis, Stefan and Sriramula, Praveena and Lear, Martin J. and Curran, Philip (2009) Evaluation of aroma-active compounds in Pontianak Orange Peel Oil (Citrus nobilis Lour. Var.microcarpaHassk.) by gas chromatography−olfactometry, aroma reconstitution, and omission test. Journal of Agricultural and Food Chemistry, 57 (1). pp. 239-244. ISSN 0021-8561

Olfractometry

Dharmawan, Jorry and Kasapis, Stefan and Sriramula, Praveena and Lear, Martin J. and Curran, Philip (2009) Evaluation of aroma-active compounds in Pontianak Orange Peel Oil (Citrus nobilis Lour. Var.microcarpaHassk.) by gas chromatography−olfactometry, aroma reconstitution, and omission test. Journal of Agricultural and Food Chemistry, 57 (1). pp. 239-244. ISSN 0021-8561

Organic methods

Kotturi, Santosh R. and Tan, Jason S. and Lear, Martin J. (2009) A mild method for the protection of alcohols using a para-methoxybenzylthio tetrazole (PMB-ST) under dual acid–base activation. Tetrahedron Letters, 50 (37). pp. 5267-5269. ISSN 0040-4039

Lear, Martin (2010) One small step for synthesis; one giant leap for total synthesis. In: 59th Natural Products Gordon Research Conference, July 25-30, 2010, Tilton, NH, USA.

Lear, Martin (2015) Routes to nine-membered enediynes: not such a walk in the park. In: 64th Gordon Research Conference (GRC) on Natural Products 2015, July 26-31, 2015, Proctor Academy, Andover, NH, USA.

Organic synthesis

Das, Parthasarathi and Mita, Takashi and Lear, Martin and Hirama, Masahiro (2002) Synthesis of 13C-labelled, bicyclic mimetics of natural enediynes. Chemical Communications (22). pp. 2624-2625. ISSN 1359-7345

Lear, Martin and Hobley, Jonathan (2008) You make it, I break it. COSMOS, 04 (01). pp. 99-129. ISSN 0219-6077

Organocatalysis

Hayashi, Yujiro and Shomura, Hiroki and Xu, Qianqian and Lear, Martin and Sato, Itaru (2015) Asymmetric aldol reaction of α,α-disubstituted acetaldehydes catalyzed by Ddphenylprolinol silyl ether for the construction of quaternary stereogenic centers. European Journal of Organic Chemistry . ISSN 1434-193X (In Press)

Organocatalyst

Liu, Xiang Hui and Song, Hong Yan and Ma, Xiao Hua and Lear, Martin J. and Chen, Yu Zong (2010) Virtual screening prediction of new potential organocatalysts for direct aldol reactions. Journal of Molecular Catalysis A: Chemical, 319 (1-2). pp. 114-118. ISSN 1381-1169

Organohalogens

Lightfoot, Ian Peter and Colston, Belinda and Dahm, R (2000) Reductive destruction of chlorinated organics in molten salt. PhD thesis, De Montfort University.

Orlistat

Ngai, Mun H. and Yang, Peng-Yu and Liu, Kai and Shen, Yuan and Wenk, Markus R. and Yao, Shao Q. and Lear, Martin J. (2010) Click-based synthesis and proteomic profiling of lipstatin analogues. Chemical Communications, 46 (44). p. 8335. ISSN 1359-7345

Yang, Peng-Yu and Liu, Kai and Ngai, Mun Hong and Lear, Martin J. and Wenk, Markus R. and Yao, Shao Q. (2010) Activity-based proteome profiling of potential cellular targets of Orlistat - an FDA-approved drug with anti-tumor activities. Journal of the American Chemical Society, 132 (2). pp. 656-666. ISSN 0002-7863

Oxazoles

Cousins, Alex R. O. and Ritson, Dougal and Sharma, Pallavi and Stevens, Malcolm F. G. and Moses, John E. and Searle, Mark S. (2014) Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences. Chemical Communications, 50 . pp. 15202-15205. ISSN 1359-7345

Palladium catalysis

Powell, Kimberley J. and Han, Li-Chen and Sharma, Pallavi and Moses, John E. (2014) Chemoselective palladium-catalyzed cyanation of alkenyl halides. Organic Letters, 16 (8). pp. 2158-2161. ISSN 1523-7060

Photo-switches

Hobley, Jonathan and Lear, Martin and Fukumura, Hiroshi (2003) Photo-switching spiropyrans and related compounds. In: Photochemistry of organic molecules in isotropic and anisotropic media. Marcel Dekker, Inc, pp. 353-404. ISBN 9780824708832, 9780203014202

Photochemistry

Hobley, Jonathan and Lear, Martin and Fukumura, Hiroshi (2003) Photo-switching spiropyrans and related compounds. In: Photochemistry of organic molecules in isotropic and anisotropic media. Marcel Dekker, Inc, pp. 353-404. ISBN 9780824708832, 9780203014202

Plasmodium

National University of Singapore (2012) Synthesis and use of fluorophore-tagged antimalarials. US20120100555 A1.

Polyketide

Powell, Kimberley J. and Sharma, Pallavi and Richens, Joanna L. and Daviss, Benjamin M. and Moses, John E. and O'Shea, Paul (2012) Interactions of marine-derived γ-pyrone natural products with phospholipid membranes. Physical Chemistry Chemical Physics, 14 (42). pp. 14489-14491. ISSN 1463-9076

Polypropionate

Sharma, Pallavi and Powell, Kimberley J. and Burnley, James and Moses, John E. and Awaad, Amani S. (2011) Total synthesis of polypropionate derived y-pyrone natural products. Synthesis, 18 . pp. 2865-2892. ISSN 0039-7881

Protecting groups

Kotturi, Santosh R. and Tan, Jason S. and Lear, Martin J. (2009) A mild method for the protection of alcohols using a para-methoxybenzylthio tetrazole (PMB-ST) under dual acid–base activation. Tetrahedron Letters, 50 (37). pp. 5267-5269. ISSN 0040-4039

Protein tyrosine kinases

Brunton, V. G. and Lear, M. and McKeown, P. and Robins, D. J. and Workman, P. (1996) Synthesis and antiproliferative activity of tyrphostins containing quinoline moieties. Anti-Cancer Drug Design, 11 (6). pp. 463-483. ISSN 0266-9536

Brunton, V. G. and Lear, M. and Robins, D. J. and Williamson, S. and Workman, P. (1994) Synthesis and antiproliferative activity of tyrphostins containing heteroaromatic moieties. Anti-Cancer Drug Design, 9 (4). pp. 291-309. ISSN 0266-9536

Radical Cation

Moore, Jonathan C. and Davies, E. Stephen and Walsh, Darren A. and Sharma, Pallavi and Moses, John E. (2014) Formal synthesis of kingianin A based upon a novel electrochemically-induced radical cation Diels–Alder reaction. Chemical communications, 50 (83). pp. 12523-12525. ISSN 1359-7345

Radical reaction

Neves, A. C. and Aitken, H. M. and Kyne, S. H. and Fensterbank, L. and Lacote, E. and Malacria, M. and Ollivier, C. and Schiesser, C. H. (2012) Intramolecular homolytic substitution of seleninates: a computational study. Tetrahedron, 68 (1). pp. 323-328. ISSN 0040-4020

Reaction kinetics

Kyne, S. H. and Lin, C. Y. and Ryu, I. and Coote, M. L. and Schiesser, C. H. (2010) First determination of the rate constant for ring-closure of an azahexenoyl radical: 6-aza-7-ethyl-5-hexenoyl. Chemical Communications, 46 (35). pp. 6521-6523. ISSN 1359-7345

SNAP-tag technology

Yang, Peng-Yu and Liu, Kai and Zhang, Chongjing and Chen, Grace Y. J. and Shen, Yuan and Ngai, Mun Hong and Lear, Martin J. and Yao, Shao Q. (2011) Chemical modification and organelle-specific localization of orlistat-like natural-product-based probes. Chemistry - An Asian Journal, 6 (10). pp. 2762-2775. ISSN 1861-4728

Selenium

MacDougall, P .E. and Aitken, H. M. and Scammells, P. J. and Kavanagh, Y. and Kyne, S. H. and Schiesser, C. H. (2012) 7-Selenabicyclo2.2.1heptane. Chemical Communications, 48 (73). pp. 9126-9128. ISSN 1359-7345

Neves, A. C. and Aitken, H. M. and Kyne, S. H. and Fensterbank, L. and Lacote, E. and Malacria, M. and Ollivier, C. and Schiesser, C. H. (2012) Intramolecular homolytic substitution of seleninates: a computational study. Tetrahedron, 68 (1). pp. 323-328. ISSN 0040-4020

Self-assembled monolayers

Siebenhofer, Bernhard and Gorelik, Sergey and Lear, Martin J. and Song, Hong Yan and Nowak, Christoph and Hobley, Jonathan (2013) Transient absorption spectroscopy on spiropyran monolayers using nanosecond pump–probe Brewster angle reflectometry. Photochemical & Photobiological Sciences, 12 (5). pp. 848-853. ISSN 1474-905X

Singapore

Lear, Martin J. and Salmons, Brian and Gunzburg, Walter H. and Dangerfield, John A. (2009) Singapore R&D and globetrotting. Biotechnology Journal, 4 (2). pp. 179-185. ISSN ISSN

Smart optical linkers

National University of Singapore (2013) A microparticle assembly. WO2013176625 A1.

Solid phase

Sharma, Pallavi and Moses, John E. (2010) Ethynyldiisopropylsilyl: a new alkynylsilane protecting group and click linker. Org. Lett., 12 (12). pp. 2860-2863. ISSN 1523-7060

Sonogashira

Yang, Eugene G. and Sekar, Karthik and Lear, Martin J. (2013) A macrolactonisation approach to the cembrane carbocycle of bielschowskysin. Tetrahedron Letters, 54 (33). pp. 4406-4408. ISSN 0040-4039

Spiropyran

Siebenhofer, Bernhard and Gorelik, Sergey and Lear, Martin J. and Song, Hong Yan and Nowak, Christoph and Hobley, Jonathan (2013) Transient absorption spectroscopy on spiropyran monolayers using nanosecond pump–probe Brewster angle reflectometry. Photochemical & Photobiological Sciences, 12 (5). pp. 848-853. ISSN 1474-905X

Spiropyran monolayers

Gorelik, Sergey and Hongyan, Song and Lear, Martin J. and Hobley, Jonathan (2010) Transient Brewster angle reflectometry of spiropyran monolayers. Photochemical and Photobiological Sciences, 9 (2). pp. 141-151. ISSN 1474-905X

Spiropyrans

Hobley, Jonathan and Lear, Martin and Fukumura, Hiroshi (2003) Photo-switching spiropyrans and related compounds. In: Photochemistry of organic molecules in isotropic and anisotropic media. Marcel Dekker, Inc, pp. 353-404. ISBN 9780824708832, 9780203014202

Stereoisomer synthesis

Kobayashi, Shoji and Das, Parthasarathi and Wang, Guang Xing and Mita, Takashi and Lear, Martin J. and Hirama, Masahiro (2002) Diastereoselective additions of ethynyl Grignard reagent to erythrulose derivatives. Chemistry Letters, 31 (3). pp. 300-301. ISSN 0366-7022

Stereoselective

Eey, Stanley T.-C. and Lear, Martin J. (2010) A bismuth(III)-catalyzed Friedel−Crafts cyclization and stereocontrolled organocatalytic approach to (−)-platensimycin. Organic Letters, 12 (23). pp. 5510-5513. ISSN 1523-7060

Stereoselective glycosylation

Lear, Martin J. and Yoshimura, Fumihiko and Hirama, Masahiro (2001) A direct and efficient α-selective glycosylation protocol for the kedarcidin sugar, L-mycarose: AgPF6 as a remarkable activator of 2-deoxythioglycosides. Angewandte Chemie International Edition, 40 (5). pp. 946-949. ISSN 1433-7851

Structure-Activity Relationship

Yang, Peng-Yu and Liu, Kai and Zhang, Chongjing and Chen, Grace Y. J. and Shen, Yuan and Ngai, Mun Hong and Lear, Martin J. and Yao, Shao Q. (2011) Chemical modification and organelle-specific localization of orlistat-like natural-product-based probes. Chemistry - An Asian Journal, 6 (10). pp. 2762-2775. ISSN 1861-4728

Sulfinamides

Kyne, Sara H. and Aitken, Heather M. and Schiesser, Carl H. and Lacote, Emmanuel and Malacria, Max and Ollivier, Cyril and Fensterbank, Louis (2011) Intramolecular homolytic substitution of sulfinates and sulfinamides: a computational study. Organic and Biomolecular Chemistry, 9 (9). pp. 3331-3337. ISSN 1477-0520

Sulfinates

Kyne, Sara H. and Aitken, Heather M. and Schiesser, Carl H. and Lacote, Emmanuel and Malacria, Max and Ollivier, Cyril and Fensterbank, Louis (2011) Intramolecular homolytic substitution of sulfinates and sulfinamides: a computational study. Organic and Biomolecular Chemistry, 9 (9). pp. 3331-3337. ISSN 1477-0520

Tetraols

Ghosh, Shibaji K. and Butler, Mark S. and Lear, Martin J. (2012) Synthesis of 2-C-methylerythritols and 2-C-methylthreitols via enantiodivergent Sharpless dihydroxylation of trisubstituted olefins. Tetrahedron Letters, 53 (22). pp. 2706-2708. ISSN 0040-4039

Tetrapeptide

Kotturi, Santosh R. and Somanadhan, Brinda and Ch’ng, Jun-Hong and Tan, Kevin S.-W. and Butler, Mark S. and Lear, Martin J. (2014) Diverted total synthesis of falcitidin acyl tetrapeptides as new antimalarial leads. Tetrahedron Letters, 55 (11). pp. 1949-1951. ISSN 0040-4039

Total synthesis

Ali, Asif and Wenk, Markus R. and Lear, Martin J. (2009) Total synthesis of a fully lipidated form of phosphatidyl-myo-inositol dimannoside (PIM-2) of Mycobacterium tuberculosis. Tetrahedron Letters, 50 (40). pp. 5664-5666. ISSN 0040-4039

Eey, Stanley T.-C. and Lear, Martin J. (2010) A bismuth(III)-catalyzed Friedel−Crafts cyclization and stereocontrolled organocatalytic approach to (−)-platensimycin. Organic Letters, 12 (23). pp. 5510-5513. ISSN 1523-7060

Kobayashi, Shoji and Ashizawa, Shukuko and Takahashi, Yusuke and Sugiura, Yukio and Nagaoka, Makoto and Lear, Martin J. and Hirama, Masahiro (2001) The first total synthesis of N1999-A2: absolute stereochemistry and stereochemical implications into DNA cleavage. Journal of the American Chemical Society, 123 (45). pp. 11294-11295. ISSN 0002-7863

Koyama, Yasuhito and Lear, Martin J. and Yoshimura, Fumihiko and Ohashi, Isao and Mashimo, Tomoko and Hirama, Masahiro (2005) Efficient construction of the kedarcidin chromophore ansamacrolide. Organic Letters, 7 (2). pp. 267-270. ISSN 1523-7060

Lear, Martin (2010) One small step for synthesis; one giant leap for total synthesis. In: 59th Natural Products Gordon Research Conference, July 25-30, 2010, Tilton, NH, USA.

Lear, Martin (2015) Routes to nine-membered enediynes: not such a walk in the park. In: 64th Gordon Research Conference (GRC) on Natural Products 2015, July 26-31, 2015, Proctor Academy, Andover, NH, USA.

Lear, Martin (2013) Synthetic ventures into the platensimycins, bielschowskysins, lipstatins, and enediynes. In: Lecture Tour, July 2013, RIKEN, Waseda University, Keio University, Sophia University, Japan.

Lear, Martin (2011) Total synthesis and drug pursuits: laetirobins, lipstatins, platensimycins [ACP Tour, Japan]. In: Asia Core Program Lectureship Tour of Japan, 18-22 Dec 2011, Nagoya, Tokyo, and Tohoku, Japan.

Lear, Martin (2012) Total synthesis and drug pursuits: the good, the bad, and the ugly. In: UK and European Lecture Tour, May - July 2012, St Andrews, Edinburgh, and Glasgow Universities (UK), EPFL (Lausanne, Switzerland), University of Strasbourg (France).

Lear, Martin and Hirai, Keiichiro and Yamada, Kei and Takahashi, Ryo and Hirama, Masahiro (2014) Total synthesis and biomimetic studies of nine-membered enediynes. In: CRC International Symposium: Synthesis and Applications of Functional Molecules and Materials Utilizing Biomolecules as a Motif, September 30, 2014, Catalytic Research Center, Hokkaido University, Japan.

Lear, Martin and Reux, Bastien and Sekar, Karthik (2012) Chemical synthesis, modification and mimicry of the GPI anchor. In: GPI membrane anchors: the much needed link. Bentham Science Publishers Ltd, pp. 64-82. ISBN 9781608051236

Lear, Martin and Yao, Shao Q. (2010) New directions for old drugs. Project Report. National University of Singapore, Singapore.

Ngai, Mun H. and Yang, Peng-Yu and Liu, Kai and Shen, Yuan and Wenk, Markus R. and Yao, Shao Q. and Lear, Martin J. (2010) Click-based synthesis and proteomic profiling of lipstatin analogues. Chemical Communications, 46 (44). p. 8335. ISSN 1359-7345

Simon, Oliver and Reux, Bastien and La Clair, James J. and Lear, Martin J. (2010) Total synthesis confirms laetirobin as a formal Diels-Alder adduct. Chemistry - An Asian Journal, 5 (2). pp. 342-351. ISSN 1861-4728

Yang, Peng-Yu and Liu, Kai and Ngai, Mun Hong and Lear, Martin J. and Wenk, Markus R. and Yao, Shao Q. (2010) Activity-based proteome profiling of potential cellular targets of Orlistat - an FDA-approved drug with anti-tumor activities. Journal of the American Chemical Society, 132 (2). pp. 656-666. ISSN 0002-7863

Yoshimura, Fumihiko and Lear, Martin J. and Ohashi, Isao and Koyama, Yasuhito and Hirama, Masahiro (2007) Synthesis of the entire carbon framework of the kedarcidin chromophore aglycon. Chemical Communications (29). p. 3057. ISSN 1359-7345

Total synthesis studies

Lear, Martin (2012) Total synthesis and drug pursuits: laetirobins, lipstatins, platensimycins. In: ZiNG Natural Products Conference 2012: Natural Products Synthesis and Biosynthesis, 10 - 13 February 2012, Lanzarote, Spain.

Lear, Martin J. and Hirama, Masahiro (1999) Convenient route to derivatives of the 2-deoxysugar subunits of the kedarcidin chromophore: L-mycarose and L-kedarosamine. Tetrahedron Letters, 40 (26). pp. 4897-4900. ISSN 0040-4039

Miao, Ru and Gramani, Subramanian G. and Lear, Martin J. (2009) Stereocontrolled entry to the tricyclo[3.3.0]oxoheptane core of bielschowskysin by a [2+2] cycloaddition of an allene-butenolide. Tetrahedron Letters, 50 (15). pp. 1731-1733. ISSN ISSN

Ohashi, Isao and Lear, Martin J. and Yoshimura, Fumihiko and Hirama, Masahiro (2004) Use of polystyrene-supported DBU in the synthesis and α-selective glycosylation study of the unstable Schmidt donor of L-kedarosamine. Organic Letters, 6 (5). pp. 719-722. ISSN 1523-7060

Transannular ring-opening

Kyne, S. H. and Miles, J. A. L. and Percy, J. M. and Singh, K. (2012) Executing and rationalizing the synthesis of a difluorinated analogue of a ring-expanded calystegine B2. Journal of Organic Chemistry, 77 (2). pp. 991-998. ISSN 0022-3263

Trifluormethyl

Kotturi, Santosh R. and Somanadhan, Brinda and Ch’ng, Jun-Hong and Tan, Kevin S.-W. and Butler, Mark S. and Lear, Martin J. (2014) Diverted total synthesis of falcitidin acyl tetrapeptides as new antimalarial leads. Tetrahedron Letters, 55 (11). pp. 1949-1951. ISSN 0040-4039

Tyrophostins

Brunton, V. G. and Lear, M. and Robins, D. J. and Williamson, S. and Workman, P. (1994) Synthesis and antiproliferative activity of tyrphostins containing heteroaromatic moieties. Anti-Cancer Drug Design, 9 (4). pp. 291-309. ISSN 0266-9536

Tyrphostins

Brunton, V. G. and Lear, M. and McKeown, P. and Robins, D. J. and Workman, P. (1996) Synthesis and antiproliferative activity of tyrphostins containing quinoline moieties. Anti-Cancer Drug Design, 11 (6). pp. 463-483. ISSN 0266-9536

Virtual screening

Liu, Xiang Hui and Song, Hong Yan and Ma, Xiao Hua and Lear, Martin J. and Chen, Yu Zong (2010) Virtual screening prediction of new potential organocatalysts for direct aldol reactions. Journal of Molecular Catalysis A: Chemical, 319 (1-2). pp. 114-118. ISSN 1381-1169

alkyne silane

Sharma, Pallavi and Moses, John E. (2010) Ethynyldiisopropylsilyl: a new alkynylsilane protecting group and click linker. Org. Lett., 12 (12). pp. 2860-2863. ISSN 1523-7060

amidation

Li, Jing and Lear, Martin and Kawamoto, Yuya and Umemiya, Shigenobu and Wong, Alice and Kwon, Eunsang and Hayashi, Yujiro (2015) Oxidative amidation of nitroalkanes with amine nucleophiles using molecular oxygen and iodine. Angewandte Chemie International Edition . ISSN 1433-7851

amide

Sharma, Pallavi and Moorhouse, Adam D. and Moses, John E. (2011) Microwave enhanced tandem azidation-amidation of anilines. Synlett, 2011 (16). pp. 2384-2386. ISSN 0936-5214

amino acid

Chavan, Subhash P. and Sharma, Pallavi and Sivappa, Rasapalli and Bhadbhade, Mohan B. and Gonnade, Rajesh G. and Kalkote, Uttam R. (2003) Enantioselective synthesis of L-CCG-I. Journal of the American Chemical Society, 68 (17). pp. 6871-6819. ISSN 0002-7863

anti-tumour agents

Simon, Oliver and Reux, Bastien and La Clair, James J. and Lear, Martin J. (2010) Total synthesis confirms laetirobin as a formal Diels-Alder adduct. Chemistry - An Asian Journal, 5 (2). pp. 342-351. ISSN 1861-4728

antimalarial

Ghosh, Shibaji K. and Somanadhan, Brinda and Tan, Kevin S.-W. and Butler, Mark S. and Lear, Martin J. (2012) Absolute configuration and total synthesis of a novel antimalarial lipopeptide by the de novo preparation of chiral nonproteinogenic amino acids. Organic Letters, 14 (6). pp. 1560-1563. ISSN 1523-7060

antiparasitic agents

Yang, Peng-Yu and Wang, Min and Liu, Kai and Ngai, Mun Hong and Sheriff, Omar and Lear, Martin J. and Sze, Siu Kwan and He, Cynthia Y. and Yao, Shao Q. (2012) Parasite-based screening and proteome profiling reveal orlistat, an FDA-approved drug, as a potential anti trypanosoma brucei agent. Chemistry - A European Journal, 18 (27). pp. 8403-8413. ISSN 0947-6539

asymmetric induction

Lear, Martin J. and Hayashi, Yujiro (2013) Remote 1,6-stereocontrol by iminium-mediated organocatalytic events. ChemCatChem, 5 (12). pp. 3499-3501. ISSN 1867-3880

azide

Sharma, Pallavi and Moorhouse, Adam D. and Moses, John E. (2011) Microwave enhanced tandem azidation-amidation of anilines. Synlett, 2011 (16). pp. 2384-2386. ISSN 0936-5214

benzenoids

Yamada, Kei and Lear, Martin J. and Yamaguchi, Takaya and Yamashita, Shuji and Gridnev, Ilya D. and Hayashi, Yujiro and Hirama, Masahiro (2014) Biomimetic total synthesis of cyanosporaside aglycons from a single enediyne precursor through site-selective p-benzyne hydrochlorination. Angewandte Chemie International Edition, 53 (50). pp. 13902-13906. ISSN 1433-7851

benzyne

Spiteri, Christian and Mason, Christopher and Zhang, Fengzhi and Ritson, Dougal J. and Sharma, Pallavi and Keeling, Steve and Moses, John E. (2010) An efficient entry to 1,2-benzisoxazoles via 1,3-dipolar cycloaddition of in situ generated nitrile oxides and benzyne. Organic and Biomolecular Chemistry Articles, 8 (11). pp. 2537-2542. ISSN 1477-0520

Spiteri, Christian and Sharma, Pallavi and Zhang, Fengzhi and Macdonald, Simon J. F. and Keeling, Steve and Moses, John E. (2010) An improved synthesis of 1,2-benzisoxazoles: TBAF mediated 1,3-dipolar cycloaddition of nitrile oxides and benzyne. Chemical Communications, 46 (8). pp. 1272-1274. ISSN 1359-7345

bioassay

Brennecke, Johannes and Ochs, Christopher J. and Boudhar, Aïcha and Reux, Bastien and Subramanian, Gomathy Sandhya and Lear, Martin J. and Trau, Dieter and Hobley, Jonathan (2014) Design, preparation and assessment of surface-immobilised tetraphenylethenes for biosensing applications. Applied Surface Science, 307 . pp. 475-481. ISSN 0169-4332

biomimetic synthesis

Sharma, Pallavi and Griffiths, Nicholas and Moses, John E. (2008) Biomimetic synthesis and structural revision of tridachiahydropyrone. Organic Letters, 10 (18). pp. 4025-4027. ISSN 1523-7060

Sharma, Pallavi and Lygo, Barry and Williams, Lewis and Moses, John E. (2009) Biomimetic synthesis and structural reassignment of the tridachiahydropyrones. Journal of the American Chemical Society, 131 (16). pp. 5966-5972. ISSN 0002-7863

bismuth

Eey, Stanley T.-C. and Lear, Martin J. (2014) Total synthesis of (−)-platensimycin by advancing oxocarbenium- and iminium-mediated catalytic methods. Chemistry - A European Journal, 20 (36). pp. 11556-11573. ISSN 0947-6539

bmjgoldcheck

Hayashi, Yujiro and Shomura, Hiroki and Xu, Qianqian and Lear, Martin and Sato, Itaru (2015) Asymmetric aldol reaction of α,α-disubstituted acetaldehydes catalyzed by Ddphenylprolinol silyl ether for the construction of quaternary stereogenic centers. European Journal of Organic Chemistry . ISSN 1434-193X (In Press)

Pasari, Sandip and Ismail, Shareef M. and Wenk, Markus R. and Lear, Martin (2015) Preparation of azide biosynthetic surrogates of myo-Inositol. Tetrahedron Letters, 56 (20). pp. 2597-2601. ISSN 0040-4039

chemical proteomics

Yang, Peng-Yu and Liu, Kai and Zhang, Chongjing and Chen, Grace Y. J. and Shen, Yuan and Ngai, Mun Hong and Lear, Martin J. and Yao, Shao Q. (2011) Chemical modification and organelle-specific localization of orlistat-like natural-product-based probes. Chemistry - An Asian Journal, 6 (10). pp. 2762-2775. ISSN 1861-4728

chemisorption

Song, Hongyan and Gorelik, Sergey and Hobley, Jonathan and Li, Jiexun and Boudhar, AÏcha and Lear, Martin J. (2013) Pyrene emission from monolayers 'clicked' onto quartz. Journal of Molecular and Engineering Materials, 01 (01). pp. 1250007-1. ISSN 2251-2373

chlorinated organics

Lightfoot, Ian Peter and Colston, Belinda and Dahm, R (2000) Reductive destruction of chlorinated organics in molten salt. PhD thesis, De Montfort University.

click chemistry

Song, Hongyan and Gorelik, Sergey and Hobley, Jonathan and Li, Jiexun and Boudhar, AÏcha and Lear, Martin J. (2013) Pyrene emission from monolayers 'clicked' onto quartz. Journal of Molecular and Engineering Materials, 01 (01). pp. 1250007-1. ISSN 2251-2373

Yang, Peng-Yu and Liu, Kai and Zhang, Chongjing and Chen, Grace Y. J. and Shen, Yuan and Ngai, Mun Hong and Lear, Martin J. and Yao, Shao Q. (2011) Chemical modification and organelle-specific localization of orlistat-like natural-product-based probes. Chemistry - An Asian Journal, 6 (10). pp. 2762-2775. ISSN 1861-4728

computational modeling

Kyne, S. H. and Lin, C. Y. and Ryu, I. and Coote, M. L. and Schiesser, C. H. (2010) First determination of the rate constant for ring-closure of an azahexenoyl radical: 6-aza-7-ethyl-5-hexenoyl. Chemical Communications, 46 (35). pp. 6521-6523. ISSN 1359-7345

Neves, A. C. and Aitken, H. M. and Kyne, S. H. and Fensterbank, L. and Lacote, E. and Malacria, M. and Ollivier, C. and Schiesser, C. H. (2012) Intramolecular homolytic substitution of seleninates: a computational study. Tetrahedron, 68 (1). pp. 323-328. ISSN 0040-4020

conjugate reduction

Eey, Stanley T.-C. and Lear, Martin J. (2014) Total synthesis of (−)-platensimycin by advancing oxocarbenium- and iminium-mediated catalytic methods. Chemistry - A European Journal, 20 (36). pp. 11556-11573. ISSN 0947-6539

conjugation

Lear, Martin J. and Hayashi, Yujiro (2013) Remote 1,6-stereocontrol by iminium-mediated organocatalytic events. ChemCatChem, 5 (12). pp. 3499-3501. ISSN 1867-3880

cyclization

Kyne, S. H. and Schiesser, C.H. (2014) N,S-Dimethyldithiocarbamyl oxalates as precursors for determining kinetic parameters for oxyacyl radicals. Chemical Communications, 50 (81). pp. 12040-12042. ISSN 1359-7345

Yamada, Kei and Lear, Martin J. and Yamaguchi, Takaya and Yamashita, Shuji and Gridnev, Ilya D. and Hayashi, Yujiro and Hirama, Masahiro (2014) Biomimetic total synthesis of cyanosporaside aglycons from a single enediyne precursor through site-selective p-benzyne hydrochlorination. Angewandte Chemie International Edition, 53 (50). pp. 13902-13906. ISSN 1433-7851

cyclopropane

Chavan, Subhash P. and Sharma, Pallavi and Sivappa, Rasapalli and Bhadbhade, Mohan B. and Gonnade, Rajesh G. and Kalkote, Uttam R. (2003) Enantioselective synthesis of L-CCG-I. Journal of the American Chemical Society, 68 (17). pp. 6871-6819. ISSN 0002-7863

dimerization

Simon, Oliver and Reux, Bastien and La Clair, James J. and Lear, Martin J. (2010) Total synthesis confirms laetirobin as a formal Diels-Alder adduct. Chemistry - An Asian Journal, 5 (2). pp. 342-351. ISSN 1861-4728

diradicals

Yamada, Kei and Lear, Martin J. and Yamaguchi, Takaya and Yamashita, Shuji and Gridnev, Ilya D. and Hayashi, Yujiro and Hirama, Masahiro (2014) Biomimetic total synthesis of cyanosporaside aglycons from a single enediyne precursor through site-selective p-benzyne hydrochlorination. Angewandte Chemie International Edition, 53 (50). pp. 13902-13906. ISSN 1433-7851

drug discovery

Yang, Peng-Yu and Wang, Min and Liu, Kai and Ngai, Mun Hong and Sheriff, Omar and Lear, Martin J. and Sze, Siu Kwan and He, Cynthia Y. and Yao, Shao Q. (2012) Parasite-based screening and proteome profiling reveal orlistat, an FDA-approved drug, as a potential anti trypanosoma brucei agent. Chemistry - A European Journal, 18 (27). pp. 8403-8413. ISSN 0947-6539

electrocyclisation

Sharma, Pallavi and Griffiths, Nicholas and Moses, John E. (2008) Biomimetic synthesis and structural revision of tridachiahydropyrone. Organic Letters, 10 (18). pp. 4025-4027. ISSN 1523-7060

Sharma, Pallavi and Lygo, Barry and Williams, Lewis and Moses, John E. (2009) Biomimetic synthesis and structural reassignment of the tridachiahydropyrones. Journal of the American Chemical Society, 131 (16). pp. 5966-5972. ISSN 0002-7863

enediynes

Yamada, Kei and Lear, Martin J. and Yamaguchi, Takaya and Yamashita, Shuji and Gridnev, Ilya D. and Hayashi, Yujiro and Hirama, Masahiro (2014) Biomimetic total synthesis of cyanosporaside aglycons from a single enediyne precursor through site-selective p-benzyne hydrochlorination. Angewandte Chemie International Edition, 53 (50). pp. 13902-13906. ISSN 1433-7851

excimer

Song, Hongyan and Gorelik, Sergey and Hobley, Jonathan and Li, Jiexun and Boudhar, AÏcha and Lear, Martin J. (2013) Pyrene emission from monolayers 'clicked' onto quartz. Journal of Molecular and Engineering Materials, 01 (01). pp. 1250007-1. ISSN 2251-2373

falcipain

Somanadhan, Brinda and Kotturi, Santosh R. and Yan Leong, Chung and Glover, Robert P. and Huang, Yicun and Flotow, Horst and Buss, Antony D. and Lear, Martin J. and Butler, Mark S. (2013) Isolation and synthesis of falcitidin, a novel myxobacterial-derived acyltetrapeptide with activity against the malaria target falcipain-2. The Journal of Antibiotics, 66 (5). pp. 259-264. ISSN 0021-8820

falcitidin

Somanadhan, Brinda and Kotturi, Santosh R. and Yan Leong, Chung and Glover, Robert P. and Huang, Yicun and Flotow, Horst and Buss, Antony D. and Lear, Martin J. and Butler, Mark S. (2013) Isolation and synthesis of falcitidin, a novel myxobacterial-derived acyltetrapeptide with activity against the malaria target falcipain-2. The Journal of Antibiotics, 66 (5). pp. 259-264. ISSN 0021-8820

fluorescent dye

Brennecke, Johannes and Ochs, Christopher J. and Boudhar, Aïcha and Reux, Bastien and Subramanian, Gomathy Sandhya and Lear, Martin J. and Trau, Dieter and Hobley, Jonathan (2014) Design, preparation and assessment of surface-immobilised tetraphenylethenes for biosensing applications. Applied Surface Science, 307 . pp. 475-481. ISSN 0169-4332

fluorescent probes

Song, Hongyan and Gorelik, Sergey and Hobley, Jonathan and Li, Jiexun and Boudhar, AÏcha and Lear, Martin J. (2013) Pyrene emission from monolayers 'clicked' onto quartz. Journal of Molecular and Engineering Materials, 01 (01). pp. 1250007-1. ISSN 2251-2373

gamma pyrone

Sharma, Pallavi and Moses, John E. (2010) Photochemical studies of the tridachiahydropyrones. Synlett, 2010 (4). pp. 525-528. ISSN 0936-5214

glycolysis

Moorhouse, Adam D. and Spiteri, Christian and Sharma, Pallavi and Zloh, Mire and Moses, John E. (2011) Targeting glycolysis: a fragment based approach towards bifunctional inhibitors of hLDH-5. Chemical Communications, 47 (1). pp. 230-232. ISSN 1359-7345

halogen bonding

Li, Jing and Lear, Martin and Kawamoto, Yuya and Umemiya, Shigenobu and Wong, Alice and Kwon, Eunsang and Hayashi, Yujiro (2015) Oxidative amidation of nitroalkanes with amine nucleophiles using molecular oxygen and iodine. Angewandte Chemie International Edition . ISSN 1433-7851

hazardous waste

Lightfoot, Ian Peter and Colston, Belinda and Dahm, R (2000) Reductive destruction of chlorinated organics in molten salt. PhD thesis, De Montfort University.

homolytic substitution

MacDougall, P .E. and Aitken, H. M. and Scammells, P. J. and Kavanagh, Y. and Kyne, S. H. and Schiesser, C. H. (2012) 7-Selenabicyclo2.2.1heptane. Chemical Communications, 48 (73). pp. 9126-9128. ISSN 1359-7345

Neves, A. C. and Aitken, H. M. and Kyne, S. H. and Fensterbank, L. and Lacote, E. and Malacria, M. and Ollivier, C. and Schiesser, C. H. (2012) Intramolecular homolytic substitution of seleninates: a computational study. Tetrahedron, 68 (1). pp. 323-328. ISSN 0040-4020

host-guest

Hernández-Alonso, D. and Zankowski, S. and Adriaenssens, L. and Ballester, P. (2015) Water-soluble aryl-extended calix[4]pyrroles with unperturbed aromatic cavities: synthesis and binding studies. Organic & Biomolecular Chemistry, 13 (4). pp. 1022-1029. ISSN 1477-0520

iminium

Lear, Martin J. and Hayashi, Yujiro (2013) Remote 1,6-stereocontrol by iminium-mediated organocatalytic events. ChemCatChem, 5 (12). pp. 3499-3501. ISSN 1867-3880

indole alkaloid

Chavan, Subhash P. and Sharma, Pallavi and Sivappa, R. and Kalkote, Uttam R. (2006) A ring closing metathesis approach to the indole alkaloid mitralactonine. Tetrahedron Letters, 47 (52). pp. 9301-9303. ISSN 0040-4039

Chavan, Subhash P. and Sharma, Pallavi and Sivappa, Rasapalli and Kalkote, Uttam R. (2007) A practical and facile approach towards indole alkaloids: (-)-mitralactonine. Synlett, 2007 (01). pp. 79-82. ISSN 0936-5214

iodination

Li, Jing and Lear, Martin and Kawamoto, Yuya and Umemiya, Shigenobu and Wong, Alice and Kwon, Eunsang and Hayashi, Yujiro (2015) Oxidative amidation of nitroalkanes with amine nucleophiles using molecular oxygen and iodine. Angewandte Chemie International Edition . ISSN 1433-7851

iodine

Chavan, Subhash P. and Sharma, Pallavi and Ramakrishna, G. and Thakkar, Mahesh (2003) Iodine as an efficient catalyst in ionic Diels–Alder reactions of α,β-unsaturated acetals. Tetrahedron Letters, 44 (14). pp. 3001-3003. ISSN 0040-4039

kinetics

Kyne, S. H. and Schiesser, C.H. (2014) N,S-Dimethyldithiocarbamyl oxalates as precursors for determining kinetic parameters for oxyacyl radicals. Chemical Communications, 50 (81). pp. 12040-12042. ISSN 1359-7345

malaria

Somanadhan, Brinda and Kotturi, Santosh R. and Yan Leong, Chung and Glover, Robert P. and Huang, Yicun and Flotow, Horst and Buss, Antony D. and Lear, Martin J. and Butler, Mark S. (2013) Isolation and synthesis of falcitidin, a novel myxobacterial-derived acyltetrapeptide with activity against the malaria target falcipain-2. The Journal of Antibiotics, 66 (5). pp. 259-264. ISSN 0021-8820

microparticles

Brennecke, Johannes and Ochs, Christopher J. and Boudhar, Aïcha and Reux, Bastien and Subramanian, Gomathy Sandhya and Lear, Martin J. and Trau, Dieter and Hobley, Jonathan (2014) Design, preparation and assessment of surface-immobilised tetraphenylethenes for biosensing applications. Applied Surface Science, 307 . pp. 475-481. ISSN 0169-4332

mitralactonine

Chavan, Subhash P. and Sharma, Pallavi and Sivappa, R. and Kalkote, Uttam R. (2006) A ring closing metathesis approach to the indole alkaloid mitralactonine. Tetrahedron Letters, 47 (52). pp. 9301-9303. ISSN 0040-4039

Chavan, Subhash P. and Sharma, Pallavi and Sivappa, Rasapalli and Kalkote, Uttam R. (2007) A practical and facile approach towards indole alkaloids: (-)-mitralactonine. Synlett, 2007 (01). pp. 79-82. ISSN 0936-5214

mollusc

Sharma, Pallavi and Griffiths, Nicholas and Moses, John E. (2008) Biomimetic synthesis and structural revision of tridachiahydropyrone. Organic Letters, 10 (18). pp. 4025-4027. ISSN 1523-7060

Sharma, Pallavi and Moses, John E. (2010) Photochemical studies of the tridachiahydropyrones. Synlett, 2010 (4). pp. 525-528. ISSN 0936-5214

monochlorination

Yamada, Kei and Lear, Martin J. and Yamaguchi, Takaya and Yamashita, Shuji and Gridnev, Ilya D. and Hayashi, Yujiro and Hirama, Masahiro (2014) Biomimetic total synthesis of cyanosporaside aglycons from a single enediyne precursor through site-selective p-benzyne hydrochlorination. Angewandte Chemie International Edition, 53 (50). pp. 13902-13906. ISSN 1433-7851

myxobacteria

Somanadhan, Brinda and Kotturi, Santosh R. and Yan Leong, Chung and Glover, Robert P. and Huang, Yicun and Flotow, Horst and Buss, Antony D. and Lear, Martin J. and Butler, Mark S. (2013) Isolation and synthesis of falcitidin, a novel myxobacterial-derived acyltetrapeptide with activity against the malaria target falcipain-2. The Journal of Antibiotics, 66 (5). pp. 259-264. ISSN 0021-8820

oapaid

Powell, Kimberley J. and Han, Li-Chen and Sharma, Pallavi and Moses, John E. (2014) Chemoselective palladium-catalyzed cyanation of alkenyl halides. Organic Letters, 16 (8). pp. 2158-2161. ISSN 1523-7060

organocatalysis

Eey, Stanley T.-C. and Lear, Martin J. (2014) Total synthesis of (−)-platensimycin by advancing oxocarbenium- and iminium-mediated catalytic methods. Chemistry - A European Journal, 20 (36). pp. 11556-11573. ISSN 0947-6539

Lear, Martin J. and Hayashi, Yujiro (2013) Remote 1,6-stereocontrol by iminium-mediated organocatalytic events. ChemCatChem, 5 (12). pp. 3499-3501. ISSN 1867-3880

orlistat

Yang, Peng-Yu and Liu, Kai and Zhang, Chongjing and Chen, Grace Y. J. and Shen, Yuan and Ngai, Mun Hong and Lear, Martin J. and Yao, Shao Q. (2011) Chemical modification and organelle-specific localization of orlistat-like natural-product-based probes. Chemistry - An Asian Journal, 6 (10). pp. 2762-2775. ISSN 1861-4728

Yang, Peng-Yu and Wang, Min and Liu, Kai and Ngai, Mun Hong and Sheriff, Omar and Lear, Martin J. and Sze, Siu Kwan and He, Cynthia Y. and Yao, Shao Q. (2012) Parasite-based screening and proteome profiling reveal orlistat, an FDA-approved drug, as a potential anti trypanosoma brucei agent. Chemistry - A European Journal, 18 (27). pp. 8403-8413. ISSN 0947-6539

p-Benzynes

Usuki, Toyonobu and Mita, Takashi and Lear, Martin J. and Das, Parthasarathi and Yoshimura, Fumihiko and Inoue, Masayuki and Hirama, Masahiro and Akiyama, Kimio and Tero-Kubota, Shozo (2004) Spin trapping of 13C-labeled p-benzynes generated by Masamune–Bergman cyclization of bicyclic nine-membered enediynes. Angewandte Chemie International Edition, 43 (39). pp. 5249-5253. ISSN 1433-7851

peptide formation

Li, Jing and Lear, Martin and Kawamoto, Yuya and Umemiya, Shigenobu and Wong, Alice and Kwon, Eunsang and Hayashi, Yujiro (2015) Oxidative amidation of nitroalkanes with amine nucleophiles using molecular oxygen and iodine. Angewandte Chemie International Edition . ISSN 1433-7851

phochemical

Sharma, Pallavi and Moses, John E. (2010) Photochemical studies of the tridachiahydropyrones. Synlett, 2010 (4). pp. 525-528. ISSN 0936-5214

photochemical

Sharma, Pallavi and Lygo, Barry and Williams, Lewis and Moses, John E. (2009) Biomimetic synthesis and structural reassignment of the tridachiahydropyrones. Journal of the American Chemical Society, 131 (16). pp. 5966-5972. ISSN 0002-7863

polypropionate

Sharma, Pallavi and Griffiths, Nicholas and Moses, John E. (2008) Biomimetic synthesis and structural revision of tridachiahydropyrone. Organic Letters, 10 (18). pp. 4025-4027. ISSN 1523-7060

Sharma, Pallavi and Lygo, Barry and Williams, Lewis and Moses, John E. (2009) Biomimetic synthesis and structural reassignment of the tridachiahydropyrones. Journal of the American Chemical Society, 131 (16). pp. 5966-5972. ISSN 0002-7863

Sharma, Pallavi and Moses, John E. (2010) Photochemical studies of the tridachiahydropyrones. Synlett, 2010 (4). pp. 525-528. ISSN 0936-5214

proteomics

Yang, Peng-Yu and Wang, Min and Liu, Kai and Ngai, Mun Hong and Sheriff, Omar and Lear, Martin J. and Sze, Siu Kwan and He, Cynthia Y. and Yao, Shao Q. (2012) Parasite-based screening and proteome profiling reveal orlistat, an FDA-approved drug, as a potential anti trypanosoma brucei agent. Chemistry - A European Journal, 18 (27). pp. 8403-8413. ISSN 0947-6539

pyrene

Song, Hongyan and Gorelik, Sergey and Hobley, Jonathan and Li, Jiexun and Boudhar, AÏcha and Lear, Martin J. (2013) Pyrene emission from monolayers 'clicked' onto quartz. Journal of Molecular and Engineering Materials, 01 (01). pp. 1250007-1. ISSN 2251-2373

radical

Kyne, S. H. and Schiesser, C.H. (2014) N,S-Dimethyldithiocarbamyl oxalates as precursors for determining kinetic parameters for oxyacyl radicals. Chemical Communications, 50 (81). pp. 12040-12042. ISSN 1359-7345

reagentless assay

Brennecke, Johannes and Ochs, Christopher J. and Boudhar, Aïcha and Reux, Bastien and Subramanian, Gomathy Sandhya and Lear, Martin J. and Trau, Dieter and Hobley, Jonathan (2014) Design, preparation and assessment of surface-immobilised tetraphenylethenes for biosensing applications. Applied Surface Science, 307 . pp. 475-481. ISSN 0169-4332

reductive destruction

Lightfoot, Ian Peter and Colston, Belinda and Dahm, R (2000) Reductive destruction of chlorinated organics in molten salt. PhD thesis, De Montfort University.

ring closing metathesis

Chavan, Subhash P. and Sharma, Pallavi and Sivappa, R. and Kalkote, Uttam R. (2006) A ring closing metathesis approach to the indole alkaloid mitralactonine. Tetrahedron Letters, 47 (52). pp. 9301-9303. ISSN 0040-4039

self assembly

Song, Hongyan and Gorelik, Sergey and Hobley, Jonathan and Li, Jiexun and Boudhar, AÏcha and Lear, Martin J. (2013) Pyrene emission from monolayers 'clicked' onto quartz. Journal of Molecular and Engineering Materials, 01 (01). pp. 1250007-1. ISSN 2251-2373

self-defence

Sharma, Pallavi and Moses, John E. (2010) Photochemical studies of the tridachiahydropyrones. Synlett, 2010 (4). pp. 525-528. ISSN 0936-5214

tetrapeptide

Somanadhan, Brinda and Kotturi, Santosh R. and Yan Leong, Chung and Glover, Robert P. and Huang, Yicun and Flotow, Horst and Buss, Antony D. and Lear, Martin J. and Butler, Mark S. (2013) Isolation and synthesis of falcitidin, a novel myxobacterial-derived acyltetrapeptide with activity against the malaria target falcipain-2. The Journal of Antibiotics, 66 (5). pp. 259-264. ISSN 0021-8820

tetraphenylethene

Brennecke, Johannes and Ochs, Christopher J. and Boudhar, Aïcha and Reux, Bastien and Subramanian, Gomathy Sandhya and Lear, Martin J. and Trau, Dieter and Hobley, Jonathan (2014) Design, preparation and assessment of surface-immobilised tetraphenylethenes for biosensing applications. Applied Surface Science, 307 . pp. 475-481. ISSN 0169-4332

thio-acid

Sharma, Pallavi and Moorhouse, Adam D. and Moses, John E. (2011) Microwave enhanced tandem azidation-amidation of anilines. Synlett, 2011 (16). pp. 2384-2386. ISSN 0936-5214

total synthesis

Eey, Stanley T.-C. and Lear, Martin J. (2014) Total synthesis of (−)-platensimycin by advancing oxocarbenium- and iminium-mediated catalytic methods. Chemistry - A European Journal, 20 (36). pp. 11556-11573. ISSN 0947-6539

Ghosh, Shibaji K. and Somanadhan, Brinda and Tan, Kevin S.-W. and Butler, Mark S. and Lear, Martin J. (2012) Absolute configuration and total synthesis of a novel antimalarial lipopeptide by the de novo preparation of chiral nonproteinogenic amino acids. Organic Letters, 14 (6). pp. 1560-1563. ISSN 1523-7060

tridachiahydropyrone

Sharma, Pallavi and Lygo, Barry and Williams, Lewis and Moses, John E. (2009) Biomimetic synthesis and structural reassignment of the tridachiahydropyrones. Journal of the American Chemical Society, 131 (16). pp. 5966-5972. ISSN 0002-7863

trypanosomiasis

Yang, Peng-Yu and Wang, Min and Liu, Kai and Ngai, Mun Hong and Sheriff, Omar and Lear, Martin J. and Sze, Siu Kwan and He, Cynthia Y. and Yao, Shao Q. (2012) Parasite-based screening and proteome profiling reveal orlistat, an FDA-approved drug, as a potential anti trypanosoma brucei agent. Chemistry - A European Journal, 18 (27). pp. 8403-8413. ISSN 0947-6539

umpolung

Li, Jing and Lear, Martin and Kawamoto, Yuya and Umemiya, Shigenobu and Wong, Alice and Kwon, Eunsang and Hayashi, Yujiro (2015) Oxidative amidation of nitroalkanes with amine nucleophiles using molecular oxygen and iodine. Angewandte Chemie International Edition . ISSN 1433-7851

water

Hernández-Alonso, D. and Zankowski, S. and Adriaenssens, L. and Ballester, P. (2015) Water-soluble aryl-extended calix[4]pyrroles with unperturbed aromatic cavities: synthesis and binding studies. Organic & Biomolecular Chemistry, 13 (4). pp. 1022-1029. ISSN 1477-0520

This list was generated on Wed Sep 2 06:40:39 2015 BST.