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ANCA associated vasculitis ATXN2 gene Adams-Oliver syndrome; NOTCH1; genetics Addison disease Adolescent Adult Age Distribution Age of Onset Aged Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Antigens, CD Antigens, CD28 Antigens, CD40 Antigens, Differentiation Antigens, Differentiation, T-Lymphocyte Apoptosis Regulatory Proteins Article Autoantibodies Autoimmune Diseases Autoimmune thyroid disease Autoimmunity B lymphocyte B lymphocyte activation BACH2 gene BTNL2 gene Bach2 gene Base Sequence Birthweight Brain size C reactive protein CADASIL CAG repeat CD4+ T lymphocyte CD40 antigen CD40 antigen, article CD8+ T lymphocyte CDC73 CTLA 4 gene CTLA4 gene CYP3A4 gene CYP3A5 gene Calcineurin Case control studies Case-Control Studies Caucasian Chi-Square Distribution Child Child, Preschool Chromosome Banding Chromosome Mapping Chromosomes, Human, Pair 1 Chromosomes, Human, Pair 18 Chromosomes, Human, Pair 20 Chromosomes, Human, Pair 9 Cluster Analysis Cohort Studies Complement System Proteins Confidence Intervals Cross-Sectional Studies Cyclophilins Cytochrome P-450 CYP3A DNA DNA Primers DNA catenation DNA determination DNA extraction DNA polymorphism DNA repair DNA replication DNA sequence DNA, article DSD Databases, Genetic Deoxyribonuclease I Diabetes Mellitus, Type 1 Disease Progression Electronic computers. Computer science England Epigenesis, Genetic Epistasis, Genetic Europe European Continental Ancestry Group Exons FCLR3 gene FCRL1 protein, human FCRL3 protein, human FCRL5 gene Fc receptor Fc receptor IIa Fc receptor IIa, antibody production Fc receptor like 3 Gene Dosage Gene Frequency Gene-Environment Interaction Genes, MHC Class II Genetic Association Studies Genetic Loci Genetic Predisposition to Disease Genetic Variation Genetic variation Genetics Genome Wide Association Studies Genome, Human Genome-Wide Association Study Genome-wide association studies Genomics Genotype Graves disease Graves disease, Case-Control Studies Graves’ disease Great Britain HDLBP gene HLA Antigens HLA B antigen HLA B27 antigen HLA C antigen HLA DQA1 antigen HLA DQB1 antigen HLA DR antigen HLA DR antigen, amino acid sequence HLA DR13 antigen HLA DR15 antigen HLA DR3 antigen HLA DR4 antigen HLA DR7 antigen HLA antigen HLA antigen class 1 HLA antigen class 2 HLA antigen class 3 HLA matching HLA system HLA-B Antigens HLA-C Antigens HLA-DQ Antigens HLA-DR Antigens Haplotypes Hashimoto Disease Hashimoto disease Histocompatibility Antigens Class I Histocompatibility Antigens Class II Holliday junctions Human Leukocyte Antigen Human genetics Humans I kappa B IFIH1 gene IL2 gene IL27 insulinoma associated antigen 2 gene IL2RA gene Immunosuppressive Agents Infant Inheritance Patterns Interleukin-13 Intracranial volume Introns JSRP1 gene Kaplan-Meier Estimate Kidney Transplantation Libyan Arab Jamahiriya Linkage Disequilibrium Linkage disequilibrium Logistic Models Lupus Erythematosus, Systemic MAGI3 gene Major Histocompatibility Complex Mantel Haenszel test Membrane Glycoproteins Membrane Proteins Mice Middle Aged Models, Genetic Mutation NBS1 NR1I2 gene Neurodegeneration Neuroscience Odds Ratio Open Reading Frames P-Glycoprotein PCA gene PICH PPIA gene PTPN22 gene Pakistan Parafibromin Phenotype Physical Chromosome Mapping Polymerase Chain Reaction Polymorphism, Genetic Polymorphism, Restriction Fragment Length Polymorphism, Single Nucleotide Population Protein Tyrosine Phosphatase, Non-Receptor Type 22 Protein Tyrosine Phosphatases Protein-Tyrosine-Phosphatase Quantitative Trait Loci RAD51 RASGRP1 gene Receptors, Cell Surface Receptors, IgG Receptors, Immunologic Receptors, Steroid Receptors, Thyrotropin Reference Values Regression Analysis Risk Risk Factors SH2B3 gene SIAE gene SRY gene STAT4 gene SUMO protein Sample Size, Europe Sequence Analysis, DNA Sex Distribution Stroke Susceptibility Loci T lymphocyte T lymphocyte, Case-Control Studies TEKT1 gene TPO gene TSHR gene, Autoimmune Diseases Taq polymerase Tg gene Thyroid Thyroid Diseases Tissue Donors Topoisomerase II Transcription Factors Transplantation, Homologous Treatment Failure Trinucleotide Repeats Tumor Necrosis Factor-alpha UBASH3A gene UFBs UNESCO UTX gene, Genome-Wide Association Study United Kingdom United Kingdom, Adaptor Proteins, Signal Transducing United Kingdom, Adolescent United Kingdom, Adult United Kingdom, Alleles United Kingdom, Autoantibodies Utopia X chromosome X chromosome inactivation acetylesterase adult aged alanine allele allotransplantation amelogenin analytic method anamnesis ankylosing spondylitis antibody blood level antibody response antigen function antigen presentation article autoantibody autoimmune disease autoimmune polyendocrinopathy candidiasis ectodermal dystrophy autoimmune regulator protein autoimmune regulator protein 1 autoimmune thyroid disease autoimmune thyroiditis autoimmunity azathioprine bacterial infection binding site biogenetics blood group ABO system bmjgoldcheck body mass cadaver kidney cancer risk cardiovascular magnetic resonance case control study caveolin 1 caveolin 1, adult celiac disease cell antigen cell line cell surface cellular senescence child cholesterol cholesterol blood level chromatin remodeling chromosome chromosome 1 chromosome 14q chromosome 18q chromosome 20q chromosome 2q chromosome 9 chromosome 9q chromosome aberration chromosome deletion X chromosome deletion Y chromosome identification chromosome instability chromosome missegregation chronic kidney disease cohort analysis comparative study complementary DNA confidence interval congenital controlled study copy number variation cyclophilin cytochrome P450 3A4 cytochrome P450 3A5 cytotoxic T lymphocyte antigen 4 deoxyribonuclease I, autoimmune disease diagnostic equipment dialysis digital disease association disease classification disease course disease incidence disease model disease predisposition donor drug design endothelial nitric oxide synthase, adult environmental factor enzyme activity epigenetics ethnic difference ethnology exon female fibroblast fibrosis follow up gastritis gender gender identity gender variance gene gene control gene expression gene frequency gene function gene identification gene interaction gene linkage disequilibrium gene location gene locus gene mapping gene replication gene sequence genetic analysis genetic association genetic epigenesis genetic identification genetic linkage genetic marker genetic polymorphism genetic predisposition genetic risk genetic screening genetic susceptibility genetic transfection genetic variability genetics genome genome analysis genome maintenance genome-wide siRNA screen genomic DNA, adult genomic DNA, chromosome 17 genotype genotype environment interaction genotype phenotype correlation global governance glomerulus filtration rate glutamate decarboxylase glutamine glycine goiter graft failure graft recipient graft survival haplotype haplotype map heart left ventricle ejection fraction heart left ventricle function heredity heritability high throughput sequencing histopathology hla dr8 antigen, antigen detection homologous recombination homozygote human human cell human; haploinsufficiency; heart defects hyperthyroidism hypothyroidism immune dysregulation immune response immune system immunogenetics immunoglobulin enhancer binding protein immunoglobulin receptor immunology immunology, ABO Blood-Group System immunopathogenesis immunopathology immunosuppressive treatment insulin insulin dependent diabetes mellitus insulinoma association antigen 2 interleukin 13, chromosome 5q interleukin 2 receptor alpha, autoimmune thyroiditis intron iodide peroxidase isolation and purification kalrn gene kidney kidney allograft kidney allograft failure kidney donor kidney fibrosis kidney graft rejection kidney transplantation letter leucine logistic regression analysis loss of function mutation lymphoid specific phosphatase protein major clinical study major histocompatibility antigen class 1 major histocompatibility antigen class 2 major histocompatibility complex male mean arterial pressure medical assessment membrane protein membrane protein, adolescent messenger RNA messenger RNA, allele meta analysis metabolism microarray analysis microsatellite marker middle aged middle aged, Autoantibodies molecular biology mortality multidrug resistance protein 1 multiple sclerosis myasthenia gravis mycophenolic acid, adult neoplasm nonhuman nonsense mutation nucleotide sequence outcome assessment pancreas islet cell antibody parent pathogenesis pathology pathology, Autoantibodies pathophysiology pernicious anemia phenomenological phenotype phenotypic variation, Autoimmune Diseases phosphatase polymerase chain reaction population genetics population risk pregnane X receptor, ABCB1 gene preschool child prevalence priority journal prognosis programmed cell death 1 gene promoter region promoter region, Alleles protein CD226 protein FCRL3 protein MAP3K7IP2 protein binding protein expression protein tyrosine phosphatase protein tyrosine phosphate nonreceptor 22 ptpn22 gene regulatory mechanism renal replacement therapy restriction fragment length polymorphism retransplantation retrospective study review rheumatoid arthritis risk risk assessment risk factor risk reduction sampling, amplicon sarcoidosis scoring system sepsis sequence analysis serine short tandem repeat sialic acid acetylesterase signal transduction single nucleotide polymorphism single nucleotide polymorphism, Acetylesterase single nucleotide polymorphism, Antigens, CD single nucleotide polymorphism, Autoimmune Diseases single nucleotide polymorphism, Case-Control Studies single nucleotide polymorphism, Chromosomes, Human, Pair 5 statistical analysis, Case-Control Studies stomach parietal cell subclinical hyperthyroidism subclinical hypothyroidism sumo 4 protein surgical mortality systemic lupus erythematosus systemic lupus erythematosus, Codon, Nonsense thyroglobulin, chromosome 8q thyroid cancer thyroid disease thyroid disease, Adolescent thyroid disease, Alleles thyroid disease, Animals thyroid disease, B-Lymphocytes thyroid microsomal antibodies thyroid peroxidase antibody thyrotropin thyrotropin receptor, allele thyrotropin receptor, article thyrotropin, adult tissue Doppler imaging transsexualism treatment failure, Adult treatment outcome, Antigens, CD trinucleotide repeat, Adult tumor necrosis factor alpha tumor necrosis factor alpha, article tumour suppressor unclassified drug unclassified drug, acquired immune deficiency syndrome unclassified drug, adult unclassified drug, antigen detection unclassified drug, article unclassified drug, autoimmune disease upregulation, Antigens, CD40 validation study vascular disease, Aged virus antigen, autoimmune disease virus infection, Bacteria (microorganisms) vitiligo, Adult
Number of items at this level: 1255.

ANCA associated vasculitis

Chand, S. and Holle, J. U. and Hilhorst, M. and Simmonds, M. J. and Smith, S. and Kamesh, L. and Hewins, P. and McKnight, A. J. and Maxwell, A. P. and Willem Cohen Tervaert, J. and Wieczorek, S. and Harper, L. and Borrows, R. (2013) Caveolin-1 single nucleotide polymorphism in antineutrophil cytoplasmic antibody associated vasculitis. PLoS ONE, 8 (7). ISSN 1932-6203

ATXN2 gene

Medici, M. and Porcu, E. and Pistis, G. and Teumer, A. and Brown, S. J. and Jensen, R. A. and Rawal, R. and Roef, G. L. and Plantinga, T. S. and Vermeulen, S. H. and Lahti, J. and Simmonds, M. J. and Husemoen, L. N. N. and Freathy, R. M. and Shields, B. M. and Pietzner, D. and Nagy, R. and Broer, L. and Chaker, L. and Korevaar, T. I. M. and Plia, M. G. and Sala, C. and Volker, U. and Richards, J. B. and Sweep, F. C. and Gieger, C. and Corre, T. and Kajantie, E. and Thuesen, B. and Taes, Y. E. and Visser, W. E. and Hattersley, A. T. and Kratzsch, J. and Hamilton, A. and Li, W. and Homuth, G. and Lobina, M. and Mariotti, S. and Soranzo, N. and Cocca, M. and Nauck, M. and Spielhagen, C. and Ross, A. and Arnold, A. and van de Bunt, M. and Liyanarachchi, S. and Heier, M. and Grabe, H. J. and Masciullo, C. and Galesloot, T. E. and Lim, E. M. and Reischl, E. and Leedman, P. J. and Lai, S. and Delitala, A. and Bremner, A. P. and Philips, D. I. W. and Beilby, J. P. and Mulas, A. and Vocale, M. and Abecasis, G. and Forsen, T. and James, A. and Widen, E. and Hui, J. and Prokisch, H. and Rietzschel, E. E. and Palotie, A. and Feddema, P. and Fletcher, S. J. and Schramm, K. and Rotter, J. I. and Kluttig, A. and Radke, D. and Traglia, M. and Surdulescu, G. L. and He, H. and Franklyn, J. A. and Tiller, D. and Vaidya, B. and de Meyer, T. and Jørgensen, T. and Eriksson, J. G. and O’Leary, P. C. and Wichmann, E. and Hermus, A. R. and Psaty, B. M. and Ittermann, T. and Hofman, A. and Bosi, E. and Schlessinger, D. and Wallaschofski, H. and Pirastu, N. and Aulchenko, Y.S. and de la Chapelle, A. and Netea-Maier, R.T. and Gough, S.C.L. and Meyer zu Schwabedissen, H. and Frayling, T.M. and Kaufman, J.M. and Linneberg, A. and Raikkonen, K. and Smit, J.W.A. and Kiemeney, L.A. and Rivadeneira, F. and Uitterlinden, A.G. and Walsh, J.P. and Meisinger, C. and den Heijer, M. and Visser, T.J. and Spector, T.D. and Wilson, S.G. and Volzke, H. and Cappola, A. and Toniolo, D. and Sanna, S. and Naitza, S. and Peeters, R.P. (2014) Identification of novel genetic loci associated with thyroid peroxidase antibodies and clinical thyroid disease. PLoS Genetics, 10 (2). ISSN 15537390

Adams-Oliver syndrome; NOTCH1; genetics

Southgate, Laura and Sukalo, Maja and Karountzos, Anastasios S. V. and Taylor, Edward J. and Collinson, Claire S. and Ruddy, Deborah and Snape, Katie M. and Dallapiccola, Bruno and Tolmie, John L. and Joss, Shelagh and Brancati, Francesco and Digilio, M. Cristina and Graul-Neumann, Luitgard M. and Salviati, Leonardo and Coerdt, Wiltrud and Jacquemin, Emmanuel and Wuyts, Wim and Zenker, Martin and Machado, Rajiv D. and Trembath, Richard C. (2015) Haploinsufficiency of the NOTCH1 receptor as a cause of Adams-Oliver Syndrome with variable cardiac anomalies. Circulation: Cardiovascular genetics, 8 (4). ISSN 1942-325X

Addison disease

Boelaert, Kristien and Newby, Paul R. and Simmonds, Matthew J. and Holder, Roger L. and Carr-Smith, Jacqueline D. and Heward, Joanne M. and Manji, Nilusha and Allahabadia, Amit and Armitage, Mary and Chatterjee, Krishna V. and Lazarus, John H. and Pearce, Simon H. and Vaidya, Bijay and Gough, Stephen C. and Franklyn, Jayne A. (2010) Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease. American Journal of Medicine, 123 (2). 183.e1-183.e9. ISSN 0002-9343

Gough, S .C. L. and Simmonds, Matthew J. (2007) The HLA region and autoimmune disease: associations and mechanisms of action. Current Genomics, 8 (7). pp. 453-465. ISSN 1389-2029

Adolescent

Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN 1553-7390

Adult

Zeitlin, A. A. and Heward, J. M. and Brand, O. J. and Newby, P. R. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2006) Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. Clinical Endocrinology, 65 (3). pp. 380-384. ISSN 0300-0664

Age Distribution

Boelaert, Kristien and Newby, Paul R. and Simmonds, Matthew J. and Holder, Roger L. and Carr-Smith, Jacqueline D. and Heward, Joanne M. and Manji, Nilusha and Allahabadia, Amit and Armitage, Mary and Chatterjee, Krishna V. and Lazarus, John H. and Pearce, Simon H. and Vaidya, Bijay and Gough, Stephen C. and Franklyn, Jayne A. (2010) Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease. American Journal of Medicine, 123 (2). 183.e1-183.e9. ISSN 0002-9343

Age of Onset

Zeitlin, A. A. and Heward, J. M. and Brand, O. J. and Newby, P. R. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2006) Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. Clinical Endocrinology, 65 (3). pp. 380-384. ISSN 0300-0664

Aged

Boelaert, Kristien and Newby, Paul R. and Simmonds, Matthew J. and Holder, Roger L. and Carr-Smith, Jacqueline D. and Heward, Joanne M. and Manji, Nilusha and Allahabadia, Amit and Armitage, Mary and Chatterjee, Krishna V. and Lazarus, John H. and Pearce, Simon H. and Vaidya, Bijay and Gough, Stephen C. and Franklyn, Jayne A. (2010) Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease. American Journal of Medicine, 123 (2). 183.e1-183.e9. ISSN 0002-9343

Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis

Chand, S. and Holle, J. U. and Hilhorst, M. and Simmonds, M. J. and Smith, S. and Kamesh, L. and Hewins, P. and McKnight, A. J. and Maxwell, A. P. and Willem Cohen Tervaert, J. and Wieczorek, S. and Harper, L. and Borrows, R. (2013) Caveolin-1 single nucleotide polymorphism in antineutrophil cytoplasmic antibody associated vasculitis. PLoS ONE, 8 (7). ISSN 1932-6203

Antigens, CD

Simmonds, M. J. and Gough, S. C. L. (2004) Unravelling the genetic complexity of autoimmune thyroid disease: HLA, CTLA-4 and beyond. Clinical and Experimental Immunology, 136 (1). pp. 1-10. ISSN 0009-9104

Antigens, CD28

Simmonds, M. J. and Gough, S. C. L. (2004) Unravelling the genetic complexity of autoimmune thyroid disease: HLA, CTLA-4 and beyond. Clinical and Experimental Immunology, 136 (1). pp. 1-10. ISSN 0009-9104

Antigens, CD40

Heward, J. M. and Simmonds, M. J. and Carr-Smith, J. and Foxall, H. and Franklyn, J. A. and Gough, S. C. L. (2004) A single nucleotide polymorphism in the CD40 gene on chromosome 20q (GD-2) provides no evidence for susceptibility to Graves' disease in UK Caucasians. Clinical Endocrinology, 61 (2). pp. 269-272. ISSN 0300-0664

Antigens, Differentiation

Simmonds, M. J. and Gough, S. C. L. (2004) Unravelling the genetic complexity of autoimmune thyroid disease: HLA, CTLA-4 and beyond. Clinical and Experimental Immunology, 136 (1). pp. 1-10. ISSN 0009-9104

Simmonds, Matthew and Gough, S. C. L. (2005) Genetic insights into disease mechanisms of autoimmunity. British Medical Bulletin, 71 (1). pp. 93-113. ISSN 0007-1420

Antigens, Differentiation, T-Lymphocyte

Hafler, J. P. and Maier, L. M. and Cooper, J. D. and Plagnol, V. and Hinks, A. and Simmonds, M. J. and Stevens, H. and Walker, N. and Healy, B. and Howson, J. M. M. and Maisuria, M. and Duley, S. and Coleman, G. and Gough, S. C. L. and Worthington, J. and Kuchroo, V. K. and Wicker, L. S. and Todd, J. A. and IMSGC, . (2009) CD226 Gly307Ser association with multiple autoimmune diseases. Genes and Immunity, 10 (1). pp. 5-10. ISSN 1466-4879

Apoptosis Regulatory Proteins

Newby, P. R. and Roberts-Davies, E. L. and Brand, O. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2007) Tag SNP screening of the PDCD1 gene for association with Graves' disease. Clinical Endocrinology, 67 (1). pp. 125-128. ISSN 0300-0664

Article

Chand, S. and Chue, C. D. and Edwards, N. C. and Hodson, J. and Simmonds, M. J. and Hamilton, A. and Gough, S. C. L. and Harper, L. and Steeds, R. P. and Townend, J. N. and Ferro, C. J. and Borrows, R. (2015) Endothelial nitric oxide synthase single nucleotide polymorphism and left ventricular function in early chronic kidney disease. PLoS ONE, 10 (1). ISSN 1932-6203

Autoantibodies

Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN 1553-7390

Autoimmune Diseases

Hafler, J. P. and Maier, L. M. and Cooper, J. D. and Plagnol, V. and Hinks, A. and Simmonds, M. J. and Stevens, H. and Walker, N. and Healy, B. and Howson, J. M. M. and Maisuria, M. and Duley, S. and Coleman, G. and Gough, S. C. L. and Worthington, J. and Kuchroo, V. K. and Wicker, L. S. and Todd, J. A. and IMSGC, . (2009) CD226 Gly307Ser association with multiple autoimmune diseases. Genes and Immunity, 10 (1). pp. 5-10. ISSN 1466-4879

Hunt, K. A. and Smyth, D. J. and Balschun, T. and Ban, M. and Mistry, V. and Ahmed, T. and Barrett, J. C. and Bhaw-Rosun, L. and Bockett, N. A. and Brand, O. J. and Brouwer, E. and Concannon, P. and Cooper, J. D. and Dias, K-R. M. and van Diemen, C. C. and Dubois, P.C. and Edkins, S. and Fölster-Holst, R. and Fransen, K. and Glass, D. N. and Heap, G. A. R. and Hofmann, S. and Huizinga, T. W. J. and Hunt, S. and Langford, C. and Lee, J. and Mansfield, J. and Giovanna Marrosu, M. and Mathew, C. G. and Mein, C.A. and Müller-Quernheim, J. and Nutland, S. and Onengut-Gumuscu, S. and Ouwehand, W. and Pearce, K. and Prescott, N. and Posthumus, M. D. and Potter, S. and Rosati, G. and Sambrook, J. and Satsangi, J. and Schreiber, S. and Shtir, C. and Simmonds, M. J. and Sudman, M. and Thompson, S. D. and Toes, R. and Trynka, G. and Vyse, T. J. and Walker, N. M. and Weidinger, S. and Zhernakova, A. and Zoledziewska, M. and Weersma, R.K. and Gough, S.C.L. and Sawcer, S. and Wijmenga, C. and Parkes, M. and Cucca, F. and Franke, A. and Deloukas, P. and Rich, S. S. and Todd, J. A. and van Heel, D. A. (2011) Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry. Nature Genetics, 44 (1). pp. 3-5. ISSN 10614036

Simmonds, M. J. and Gough, S. C. L. (2004) Unravelling the genetic complexity of autoimmune thyroid disease: HLA, CTLA-4 and beyond. Clinical and Experimental Immunology, 136 (1). pp. 1-10. ISSN 0009-9104

Simmonds, Matthew and Gough, S. C. L. (2005) Genetic insights into disease mechanisms of autoimmunity. British Medical Bulletin, 71 (1). pp. 93-113. ISSN 0007-1420

Autoimmune thyroid disease

Hamilton, Alexander and Gough, Stephen C. L. and Simmonds, Matthew J. (2013) Genetics of Graves’ disease. In: eLS - Encyclopedia of Life Sciences. Wiley. ISBN 9780470015902

Autoimmunity

Hamilton, Alexander and Gough, Stephen C. L. and Simmonds, Matthew J. (2013) Genetics of Graves’ disease. In: eLS - Encyclopedia of Life Sciences. Wiley. ISBN 9780470015902

B lymphocyte

Simmonds, Matthew J. (2013) GWAS in autoimmune thyroid disease: redefining our understanding of pathogenesis. Nature Reviews Endocrinology, 9 (5). pp. 277-287. ISSN 1759-5029

Simmonds, Matthew J. and Brand, Oliver J. and Barrett, Jeffrey C. and Newby, Paul R. and Franklyn, Jayne A. and Gough, Stephen C. L. (2010) Association of Fc receptor-like 5 (FCRL5) with Graves' disease is secondary to the effect of FCRL3. Clinical Endocrinology, 73 (5). pp. 654-660. ISSN 0300-0664

Simmonds, Matthew J. and Heward, J. M. and Carr-Smith, J. and Foxall, H. and Franklyn, J. A. and Gough, S. C. L. (2006) Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease. Journal of Clinical Endocrinology and Metabolism, 91 (3). pp. 1056-1061. ISSN 0021-972X

B lymphocyte activation

Simmonds, M. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. (2005) The CD40 Kozak SNP: a new susceptibility loci for Graves' disease? Clinical Endocrinology, 63 (2). pp. 232-233. ISSN 0300 0664

BACH2 gene

Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN 1553-7390

BTNL2 gene

Simmonds, M. J. and Heward, J. M. and Barrett, J. C. and Franklyn, J. A. and Gough, S. C. L. (2006) Association of the BTNL2 rs2076530 single nucleotide polymorphism with Graves' disease appears to be secondary to DRB1 exon 2 position beta74. Clinical Endocrinology, 65 (4). pp. 429-432. ISSN 0300-0664

Bach2 gene

Medici, M. and Porcu, E. and Pistis, G. and Teumer, A. and Brown, S. J. and Jensen, R. A. and Rawal, R. and Roef, G. L. and Plantinga, T. S. and Vermeulen, S. H. and Lahti, J. and Simmonds, M. J. and Husemoen, L. N. N. and Freathy, R. M. and Shields, B. M. and Pietzner, D. and Nagy, R. and Broer, L. and Chaker, L. and Korevaar, T. I. M. and Plia, M. G. and Sala, C. and Volker, U. and Richards, J. B. and Sweep, F. C. and Gieger, C. and Corre, T. and Kajantie, E. and Thuesen, B. and Taes, Y. E. and Visser, W. E. and Hattersley, A. T. and Kratzsch, J. and Hamilton, A. and Li, W. and Homuth, G. and Lobina, M. and Mariotti, S. and Soranzo, N. and Cocca, M. and Nauck, M. and Spielhagen, C. and Ross, A. and Arnold, A. and van de Bunt, M. and Liyanarachchi, S. and Heier, M. and Grabe, H. J. and Masciullo, C. and Galesloot, T. E. and Lim, E. M. and Reischl, E. and Leedman, P. J. and Lai, S. and Delitala, A. and Bremner, A. P. and Philips, D. I. W. and Beilby, J. P. and Mulas, A. and Vocale, M. and Abecasis, G. and Forsen, T. and James, A. and Widen, E. and Hui, J. and Prokisch, H. and Rietzschel, E. E. and Palotie, A. and Feddema, P. and Fletcher, S. J. and Schramm, K. and Rotter, J. I. and Kluttig, A. and Radke, D. and Traglia, M. and Surdulescu, G. L. and He, H. and Franklyn, J. A. and Tiller, D. and Vaidya, B. and de Meyer, T. and Jørgensen, T. and Eriksson, J. G. and O’Leary, P. C. and Wichmann, E. and Hermus, A. R. and Psaty, B. M. and Ittermann, T. and Hofman, A. and Bosi, E. and Schlessinger, D. and Wallaschofski, H. and Pirastu, N. and Aulchenko, Y.S. and de la Chapelle, A. and Netea-Maier, R.T. and Gough, S.C.L. and Meyer zu Schwabedissen, H. and Frayling, T.M. and Kaufman, J.M. and Linneberg, A. and Raikkonen, K. and Smit, J.W.A. and Kiemeney, L.A. and Rivadeneira, F. and Uitterlinden, A.G. and Walsh, J.P. and Meisinger, C. and den Heijer, M. and Visser, T.J. and Spector, T.D. and Wilson, S.G. and Volzke, H. and Cappola, A. and Toniolo, D. and Sanna, S. and Naitza, S. and Peeters, R.P. (2014) Identification of novel genetic loci associated with thyroid peroxidase antibodies and clinical thyroid disease. PLoS Genetics, 10 (2). ISSN 15537390

Base Sequence

Simmonds, Matthew J. and Heward, J. M. and Carr-Smith, J. and Foxall, H. and Franklyn, J. A. and Gough, S. C. L. (2006) Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease. Journal of Clinical Endocrinology and Metabolism, 91 (3). pp. 1056-1061. ISSN 0021-972X

Birthweight

Wang, Guoying and Ali Khan, Anokhi and Rodriguez, Alina and Sebert, Sylvain and Kaakinen, Marika and Cauchi, Stéphane and Froguel, Philippe and Hartikainen, Anna-Liisa and Pouta, Anneli and Järvelin, Marjo-Riitta (2012) The interplay of variants near LEKR and CCNL1 and social stress in relation to birth size. PLoS ONE, 7 (6). e38216. ISSN 1932-6203

Brain size

Ikram, M. Arfan and Fornage, Myriam and Smith, Albert V. and Seshadri, Sudha and Schmidt, Reinhold and Debette, Stéphanie and Vrooman, Henri A. and Sigurdsson, Sigurdur and Ropele, Stefan and Taal, H. Rob and Mook-Kanamori, Dennis O. and Coker, Laura H. and Longstreth, W. T. and Niessen, Wiro J. and DeStefano, Anita L. and Beiser, Alexa and Zijdenbos, Alex P. and Struchalin, Maksim and Jack, Clifford R. and Rivadeneira, Fernando and Uitterlinden, Andre G. and Knopman, David S. and Hartikainen, Anna-Liisa and Pennell, Craig E. and Thiering, Elisabeth and Steegers, Eric A. P. and Hakonarson, Hakon and Heinrich, Joachim and Palmer, Lyle J. and Jarvelin, Marjo-Riitta and McCarthy, Mark I. and Grant, Struan F. A. and Pourcain, Beate St and Timpson, Nicholas J. and Smith, George Davey and Sovio, Ulla and Nalls, Mike A. and Au, Rhoda and Hofman, Albert and Gudnason, Haukur and van der Lugt, Aad and Harris, Tamara B. and Meeks, William M. and Vernooij, Meike W. and van Buchem, Mark A. and Catellier, Diane and Jaddoe, Vincent W. V. and Gudnason, Vilmundur and Windham, B. Gwen and Wolf, Philip A. and van Duijn, Cornelia M. and Mosley, Thomas H. and Schmidt, Helena and Launer, Lenore J. and Breteler, Monique M. B. and DeCarli, Charles and Adair, Linda S. and Ang, Wei and Atalay, Mustafa and van Beijsterveldt, Toos and Bergen, Nienke and Benke, Kelly and Berry, Diane and Coin, Lachlan and Davis, Oliver S. P. and Elliott, Paul and Flexeder, Claudia and Frayling, Tim and Gaillard, Romy and Groen-Blokhuis, Maria and Goh, Liang-Kee and Haworth, Claire M. A. and Hadley, Dexter and Hedebrand, Johannes and Hinney, Anke and Hirschhorn, Joel N. and Holloway, John W. and Holst, Claus and Jan Hottenga, Jouke and Horikoshi, Momoko and Huikari, Ville and Hypponen, Elina and Kilpeläinen, Tuomas O. and Kirin, Mirna and Kowgier, Matthew and Lakka, Hanna-Maaria and Lange, Leslie A. and Lawlor, Debbie A. and Lehtimäki, Terho and Lewin, Alex and Lindgren, Cecilia and Lindi, Virpi and Maggi, Reedik and Marsh, Julie and Middeldorp, Christel and Millwood, Iona and Murray, Jeffrey C. and Nivard, Michel and Nohr, Ellen Aagaard and Ntalla, Ioanna and Oken, Emily and Panoutsopoulou, Kalliope and Pararajasingham, Jennifer and Rodriguez, Alina and Salem, Rany M. and Sebert, Sylvain and Siitonen, Niina and Strachan, David P. and Teo, Yik-Ying and Valcárcel, Beatriz and Willemsen, Gonneke and Zeggini, Eleftheria and Boomsma, Dorret I. and Cooper, Cyrus and Gillman, Matthew and Hocher, Berthold and Lakka, Timo A. and Mohlke, Karen L. and Dedoussis, George V. and Ong, Ken K. and Pearson, Ewan R. and Price, Thomas S. and Power, Chris and Raitakari, Olli T. and Saw, Seang-Mei and Scherag, Andre and Simell, Olli and Sørensen, Thorkild I. A. and Wilson, James F. (2012) Common variants at 6q22 and 17q21 are associated with intracranial volume. Nature Genetics, 44 (5). pp. 539-544. ISSN 1061-4036

Taal, H. Rob and St Pourcain, Beate and Thiering, Elisabeth and Das, Shikta and Mook-Kanamori, Dennis O. and Warrington, Nicole M. and Kaakinen, Marika and Kreiner-Møller, Eskil and Bradfield, Jonathan P. and Freathy, Rachel M. and Geller, Frank and Guxens, Mònica and Cousminer, Diana L. and Kerkhof, Marjan and Timpson, Nicholas J. and Ikram, M. Arfan and Beilin, Lawrence J. and Bønnelykke, Klaus and Buxton, Jessica L. and Charoen, Pimphen and Chawes, Bo Lund Krogsgaard and Eriksson, Johan and Evans, David M. and Hofman, Albert and Kemp, John P. and Kim, Cecilia E. and Klopp, Norman and Lahti, Jari and Lye, Stephen J. and McMahon, George and Mentch, Frank D. and Müller-Nurasyid, Martina and O'Reilly, Paul F. and Prokopenko, Inga and Rivadeneira, Fernando and Steegers, Eric A. P. and Sunyer, Jordi and Tiesler, Carla and Yaghootkar, Hanieh and Fornage, Myriam and Smith, Albert V. and Seshadri, Sudha and Schmidt, Reinhold and Debette, Stéphanie and Vrooman, Henri A. and Sigurdsson, Sigurdur and Ropele, Stefan and Coker, Laura H. and Longstreth, W. T. and Niessen, Wiro J. and DeStefano, Anita L. and Beiser, Alexa and Zijdenbos, Alex P. and Struchalin, Maksim and Jack, Clifford R. and Nalls, Mike A. and Au, Rhoda and Gudnason, Haukur and van der Lugt, Aad and Harris, Tamara B. and Meeks, William M. and Vernooij, Meike W. and van Buchem, Mark A. and Catellier, Diane and Gudnason, Vilmundur and Windham, B. Gwen and Wolf, Philip A. and van Duijn, Cornelia M. and Mosley, Thomas H. and Schmidt, Helena and Launer, Lenore J. and Breteler, Monique M. B. and DeCarli, Charles and Mosley, Thomas and Ang, Wei and van Beijsterveldt, Toos and Bergen, Nienke and Benke, Kelly and Berry, Diane and Coin, Lachlan and Elliott, Paul and Frayling, Tim and Gaillard, Romy and Groen-Blokhuis, Maria and Hadley, Dexter and Hottenga, Jouke Jan and Huikari, Ville and Hypponen, Elina and Kowgier, Matthew and Lawlor, Debbie A. and Lewin, Alex and Lindgren, Cecilia and Marsh, Julie and Middeldorp, Christel and Millwood, Iona and Nivard, Michel and Palmer, Lyle J. and Rodriguez, Alina and Sebert, Sylvain and Standl, Marie and Strachan, David P. and Uitterlinden, Andre G. and Valcárcel, Beatriz and White, Scott and Willemsen, Gonneke and Boomsma, Dorret I. and Grant, Struan F. A. and Hakonarson, Hakon and Hattersley, Andrew T. and Heinrich, Joachim and Jaddoe, Vincent W. V. and McCarthy, Mark I. and Pennell, Craig E. and Power, Chris and Widen, Elisabeth and Blakemore, Alexandra I. F. and Chiavacci, Rosetta M. and Feenstra, Bjarke and Fernandez-Banet, Julio and Hartikainen, Anna-Liisa and van der Heijden, Albert J. and Iñiguez, Carmen and Lathrop, Mark and McArdle, Wendy L. and Mølgaard, Anne and Newnham, John P. and Palotie, Aarno and Pouta, Annneli and Ring, Susan M. and Sovio, Ulla and Wichmann, H-Erich and Vissing, Nadja Hawwa and van Duijn, Cornelia M. and Koppelman, Gerard H. and Melbye, Mads and Bisgaard, Hans and Smith, George Davey and Adair, Linda S. and Atalay, Mustafa and Davis, Oliver S. P. and Flexeder, Claudia and Goh, Liang-Kee and Haworth, Claire M. A. and Hedebrand, Johannes and Hinney, Anke and Hirschhorn, Joel N. and Holloway, John W. and Holst, Claus and Horikoshi, Momoko and Kilpeläinen, Tuomas O. and Kirin, Mirna and Lakka, Hanna-Maaria and Lange, Leslie A. and Lehtimäki, Terho and Lindi, Virpi and Maggi, Reedik and Murray, Jeffrey C. and Nohr, Ellen Aagaard and Ntalla, Ioanna and Oken, Emily and Panoutsopoulou, Kalliope and Pararajasingham, Jennifer and Salem, Rany M. and Siitonen, Niina and Teo, Yik-Ying and Zeggini, Eleftheria and Cooper, Cyrus and Estivill, Xavier and Gillman, Matthew and Hocher, Berthold and Jarvelin, Marjo-Riitta and Lakka, Timo A. and Mohlke, Karen L. and Dedoussis, George V. and Ong, Ken K. and Pearson, Ewan R. and Price, Thomas S. and Raitakari, Olli T. and Saw, Seang-Mei and Scherag, Andre and Simell, Olli and Sørensen, Thorkild I. A. and Wilson, James F. (2012) Common variants at 12q15 and 12q24 are associated with infant head circumference. Nature Genetics, 44 (5). pp. 532-538. ISSN 1061-4036

C reactive protein

Chand, S. and Chue, C. D. and Edwards, N. C. and Hodson, J. and Simmonds, M. J. and Hamilton, A. and Gough, S. C. L. and Harper, L. and Steeds, R. P. and Townend, J. N. and Ferro, C. J. and Borrows, R. (2015) Endothelial nitric oxide synthase single nucleotide polymorphism and left ventricular function in early chronic kidney disease. PLoS ONE, 10 (1). ISSN 1932-6203

CADASIL

Kilarski, Laura L. and Rutten-Jacobs, Loes C. A. and Bevan, Stephen and Baker, Rob and Hassan, Ahamad and Hughes, Derralynn A. and Markus, Hugh S. (2015) Prevalence of CADASIL and Fabry disease in a cohort of MRI defined younger onset lacunar stroke. PloS one, 10 (8). e0136352. ISSN 1932-6203

CAG repeat

Simmonds, Matthew J. and Benavente, David and Brand, Oliver J. and Moore, Jason and Ball, Simon and Ferro, Charles J. and Briggs, David and Gough, Stephen C. L. and Borrows, Richard J. (2013) Skewing of female X-chromosome inactivation: an epigenetic risk factor for kidney transplantation outcome. Transplantation, 95 (5). e25-e28. ISSN 0041-1337

CD4+ T lymphocyte

Gough, S .C. L. and Simmonds, Matthew J. (2007) The HLA region and autoimmune disease: associations and mechanisms of action. Current Genomics, 8 (7). pp. 453-465. ISSN 1389-2029

CD40 antigen

Simmonds, M. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. (2005) The CD40 Kozak SNP: a new susceptibility loci for Graves' disease? Clinical Endocrinology, 63 (2). pp. 232-233. ISSN 0300 0664

CD40 antigen, article

Heward, J. M. and Simmonds, M. J. and Carr-Smith, J. and Foxall, H. and Franklyn, J. A. and Gough, S. C. L. (2004) A single nucleotide polymorphism in the CD40 gene on chromosome 20q (GD-2) provides no evidence for susceptibility to Graves' disease in UK Caucasians. Clinical Endocrinology, 61 (2). pp. 269-272. ISSN 0300-0664

CD8+ T lymphocyte

Gough, S .C. L. and Simmonds, Matthew J. (2007) The HLA region and autoimmune disease: associations and mechanisms of action. Current Genomics, 8 (7). pp. 453-465. ISSN 1389-2029

CDC73

Herr, Patrick and Lundin, Cecilia and Evers, Bastiaan and Ebner, Daniel and Bauerschmidt, Christina and Kingham, Guy and Palmai-Pallag, Timea and Mortusewicz, Oliver and Frings, Oliver and Sonnhammer, Erik and Helleday, Thomas (2015) A genome-wide IR-induced RAD51 foci RNAi screen identifies CDC73 involved in chromatin remodeling for DNA repair. Cell Discovery . p. 15034. ISSN 2056-5968

CTLA 4 gene

Zeitlin, A. and Simmonds, M. J. and Gough, S. C. (2008) Genetic developments in autoimmune thyroid disease: an evolutionary process. Clinical Endocrinology, 68 (5). pp. 671-682. ISSN 0300-0664

CTLA4 gene

Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN 1553-7390

CYP3A4 gene

Moore, Jason and McKnight, Amy Jayne and Döhler, Bernd and Simmonds, Matthew J. and Courtney, Aisling E. and Brand, Oliver J. and Briggs, David and Ball, Simon and Cockwell, Paul and Patterson, Christopher C. and Maxwell, Alexander P. and Gough, Stephen C. L. and Opelz, Gerhard and Borrows, Richard (2012) Donor ABCB1 variant associates with increased risk for kidney allograft failure. Journal of the American Society of Nephrology, 23 (11). pp. 1891-1899. ISSN 1046-6673

CYP3A5 gene

Moore, Jason and McKnight, Amy Jayne and Döhler, Bernd and Simmonds, Matthew J. and Courtney, Aisling E. and Brand, Oliver J. and Briggs, David and Ball, Simon and Cockwell, Paul and Patterson, Christopher C. and Maxwell, Alexander P. and Gough, Stephen C. L. and Opelz, Gerhard and Borrows, Richard (2012) Donor ABCB1 variant associates with increased risk for kidney allograft failure. Journal of the American Society of Nephrology, 23 (11). pp. 1891-1899. ISSN 1046-6673

Calcineurin

Moore, Jason and McKnight, Amy Jayne and Döhler, Bernd and Simmonds, Matthew J. and Courtney, Aisling E. and Brand, Oliver J. and Briggs, David and Ball, Simon and Cockwell, Paul and Patterson, Christopher C. and Maxwell, Alexander P. and Gough, Stephen C. L. and Opelz, Gerhard and Borrows, Richard (2012) Donor ABCB1 variant associates with increased risk for kidney allograft failure. Journal of the American Society of Nephrology, 23 (11). pp. 1891-1899. ISSN 1046-6673

Case control studies

Hamilton, Alexander and Gough, Stephen C. L. and Simmonds, Matthew J. (2013) Genetics of Graves’ disease. In: eLS - Encyclopedia of Life Sciences. Wiley. ISBN 9780470015902

Case-Control Studies

Cooper, J. D. and Simmonds, M. J. and Walker, N.M. and Burren, O. and Brand, O.J. and Guo, H. and Wallace, C. and Stevens, H. and Coleman, G and Franklyn, J.A. and Todd, J.A. and Gough, S.C.L. (2012) Seven newly identified loci for autoimmune thyroid disease. Human Molecular Genetics, 21 (23). pp. 5202-5208. ISSN 0964-6906

Hafler, J. P. and Maier, L. M. and Cooper, J. D. and Plagnol, V. and Hinks, A. and Simmonds, M. J. and Stevens, H. and Walker, N. and Healy, B. and Howson, J. M. M. and Maisuria, M. and Duley, S. and Coleman, G. and Gough, S. C. L. and Worthington, J. and Kuchroo, V. K. and Wicker, L. S. and Todd, J. A. and IMSGC, . (2009) CD226 Gly307Ser association with multiple autoimmune diseases. Genes and Immunity, 10 (1). pp. 5-10. ISSN 1466-4879

Heward, J. M. and Simmonds, M. J. and Carr-Smith, J. and Foxall, H. and Franklyn, J. A. and Gough, S. C. L. (2004) A single nucleotide polymorphism in the CD40 gene on chromosome 20q (GD-2) provides no evidence for susceptibility to Graves' disease in UK Caucasians. Clinical Endocrinology, 61 (2). pp. 269-272. ISSN 0300-0664

Newby, P. R. and Roberts-Davies, E. L. and Brand, O. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2007) Tag SNP screening of the PDCD1 gene for association with Graves' disease. Clinical Endocrinology, 67 (1). pp. 125-128. ISSN 0300-0664

Todd, J. A. and Walker, N. M. and Cooper, J. D. and Smyth, D. J. and Downes, K. and Plagnol, V. and Bailey, R. and Nejentsev, S. and Field, S. F. and Payne, F. and Lowe, C. E. and Szeszko, J. S. and Hafler, J. P. and Zeitels, L. and Yang, J. H. M. and Vella, A. and Nutland, S. and Stevens, H. E. and Schuilenburg, H. and Coleman, G. and Maisuria, M. and Meadows, W. and Smink, L. J. and Healy, B. and Burren, O. S. and Lam, A. A. C. and Ovington, N. R. and Allen, J. and Adlem, E. and Leung, H-T. and Wallace, C. and Howson, J. M. M. and Guja, C. and Ionescu-Tırgoviste, C. and Genetics of T1D in Finland, . and Simmonds, M. J. and Heward, J. M. and Gough, S. C. L. and WTCCC, . and Dunger, D. B. and Wicker, L. S. and Clayton, D. G. (2007) Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nature Genetics, 39 (7). pp. 857-864. ISSN 1061-4036

Yesmin, K. and Hargreaves, C. and Newby, P. R. and Brand, O. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2010) Association of FcGRIIa with Graves' disease: a potential role for dysregulated autoantibody clearance in disease onset/progression. Clinical Endocrinology, 73 (1). pp. 119-125. ISSN 0300-0664

Zeitlin, A. A. and Heward, J. M. and Brand, O. J. and Newby, P. R. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2006) Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. Clinical Endocrinology, 65 (3). pp. 380-384. ISSN 0300-0664

Zeitlin, A. A. and Heward, J. M. and Newby, P. R. and Carr-Smith, J. D. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2008) Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. Genes and Immunity, 9 (4). pp. 358-363. ISSN 1466-4879

Caucasian

Boelaert, Kristien and Newby, Paul R. and Simmonds, Matthew J. and Holder, Roger L. and Carr-Smith, Jacqueline D. and Heward, Joanne M. and Manji, Nilusha and Allahabadia, Amit and Armitage, Mary and Chatterjee, Krishna V. and Lazarus, John H. and Pearce, Simon H. and Vaidya, Bijay and Gough, Stephen C. and Franklyn, Jayne A. (2010) Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease. American Journal of Medicine, 123 (2). 183.e1-183.e9. ISSN 0002-9343

Chand, S. and Holle, J. U. and Hilhorst, M. and Simmonds, M. J. and Smith, S. and Kamesh, L. and Hewins, P. and McKnight, A. J. and Maxwell, A. P. and Willem Cohen Tervaert, J. and Wieczorek, S. and Harper, L. and Borrows, R. (2013) Caveolin-1 single nucleotide polymorphism in antineutrophil cytoplasmic antibody associated vasculitis. PLoS ONE, 8 (7). ISSN 1932-6203

Heward, J. M. and Simmonds, M. J. and Carr-Smith, J. and Foxall, H. and Franklyn, J. A. and Gough, S. C. L. (2004) A single nucleotide polymorphism in the CD40 gene on chromosome 20q (GD-2) provides no evidence for susceptibility to Graves' disease in UK Caucasians. Clinical Endocrinology, 61 (2). pp. 269-272. ISSN 0300-0664

Simmonds, M. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. (2005) The CD40 Kozak SNP: a new susceptibility loci for Graves' disease? Clinical Endocrinology, 63 (2). pp. 232-233. ISSN 0300 0664

Simmonds, M. J. and Heward, J.M. and Howson, J.M.M. and Foxall, H. and Nithiyananthan, R. and Franklyn, J.A. and Gough, S.C.L. (2004) A systematic approach to the assesment of known TNF-alpha polymorphisms in Graves' disease. Genes and Immunity, 5 (4). pp. 267-273. ISSN 1466-4879

Simmonds, M. J. and Howson, J. M. M. and Heward, J. M. and Carr-Smith, J. and Franklyn, J. A. and Todd, J. A. and Gough, S. C. L. (2007) A novel and major association of HLA-C in Graves' disease that eclipses the classical HLA-DRB1 effect. Human Molecular Genetics, 16 (18). pp. 2149-2153. ISSN 0964-6906

Simmonds, Matthew J. and Brand, Oliver J. and Barrett, Jeffrey C. and Newby, Paul R. and Franklyn, Jayne A. and Gough, Stephen C. L. (2010) Association of Fc receptor-like 5 (FCRL5) with Graves' disease is secondary to the effect of FCRL3. Clinical Endocrinology, 73 (5). pp. 654-660. ISSN 0300-0664

Zeitlin, A. A. and Heward, J. M. and Brand, O. J. and Newby, P. R. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2006) Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. Clinical Endocrinology, 65 (3). pp. 380-384. ISSN 0300-0664

Zeitlin, A. A. and Heward, J. M. and Newby, P. R. and Carr-Smith, J. D. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2008) Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. Genes and Immunity, 9 (4). pp. 358-363. ISSN 1466-4879

Chi-Square Distribution

Newby, P. R. and Roberts-Davies, E. L. and Brand, O. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2007) Tag SNP screening of the PDCD1 gene for association with Graves' disease. Clinical Endocrinology, 67 (1). pp. 125-128. ISSN 0300-0664

Simmonds, M. J. and Heward, J. M. and Barrett, J. C. and Franklyn, J. A. and Gough, S. C. L. (2006) Association of the BTNL2 rs2076530 single nucleotide polymorphism with Graves' disease appears to be secondary to DRB1 exon 2 position beta74. Clinical Endocrinology, 65 (4). pp. 429-432. ISSN 0300-0664

Zeitlin, A. A. and Heward, J. M. and Brand, O. J. and Newby, P. R. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2006) Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. Clinical Endocrinology, 65 (3). pp. 380-384. ISSN 0300-0664

Zeitlin, A. A. and Heward, J. M. and Newby, P. R. and Carr-Smith, J. D. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2008) Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. Genes and Immunity, 9 (4). pp. 358-363. ISSN 1466-4879

Child

Zeitlin, A. A. and Heward, J. M. and Brand, O. J. and Newby, P. R. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2006) Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. Clinical Endocrinology, 65 (3). pp. 380-384. ISSN 0300-0664

Child, Preschool

Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN 1553-7390

Zeitlin, A. A. and Heward, J. M. and Brand, O. J. and Newby, P. R. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2006) Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. Clinical Endocrinology, 65 (3). pp. 380-384. ISSN 0300-0664

Chromosome Banding

Cooper, J. D. and Simmonds, M. J. and Walker, N.M. and Burren, O. and Brand, O.J. and Guo, H. and Wallace, C. and Stevens, H. and Coleman, G and Franklyn, J.A. and Todd, J.A. and Gough, S.C.L. (2012) Seven newly identified loci for autoimmune thyroid disease. Human Molecular Genetics, 21 (23). pp. 5202-5208. ISSN 0964-6906

Chromosome Mapping

Cooper, J. D. and Simmonds, M. J. and Walker, N.M. and Burren, O. and Brand, O.J. and Guo, H. and Wallace, C. and Stevens, H. and Coleman, G and Franklyn, J.A. and Todd, J.A. and Gough, S.C.L. (2012) Seven newly identified loci for autoimmune thyroid disease. Human Molecular Genetics, 21 (23). pp. 5202-5208. ISSN 0964-6906

Simmonds, Matthew J. (2013) GWAS in autoimmune thyroid disease: redefining our understanding of pathogenesis. Nature Reviews Endocrinology, 9 (5). pp. 277-287. ISSN 1759-5029

Simmonds, Matthew J. and Howson, Joanna M. M. and Heward, Joanne M. and Cordell, Heather J. and Foxall, Helen and Carr-Smith, Jackie and Gibson, Sarah M. and Walker, Neil and Tomer, Yaron and Franklyn, Jayne A. and Todd, John A. and Gough, Stephen C. L. (2005) Regression mapping of association between the human leukocyte antigen region and Graves' disease. American Journal of Human Genetics, 76 (1). pp. 157-163. ISSN 0002-9297

Todd, J. A. and Walker, N. M. and Cooper, J. D. and Smyth, D. J. and Downes, K. and Plagnol, V. and Bailey, R. and Nejentsev, S. and Field, S. F. and Payne, F. and Lowe, C. E. and Szeszko, J. S. and Hafler, J. P. and Zeitels, L. and Yang, J. H. M. and Vella, A. and Nutland, S. and Stevens, H. E. and Schuilenburg, H. and Coleman, G. and Maisuria, M. and Meadows, W. and Smink, L. J. and Healy, B. and Burren, O. S. and Lam, A. A. C. and Ovington, N. R. and Allen, J. and Adlem, E. and Leung, H-T. and Wallace, C. and Howson, J. M. M. and Guja, C. and Ionescu-Tırgoviste, C. and Genetics of T1D in Finland, . and Simmonds, M. J. and Heward, J. M. and Gough, S. C. L. and WTCCC, . and Dunger, D. B. and Wicker, L. S. and Clayton, D. G. (2007) Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nature Genetics, 39 (7). pp. 857-864. ISSN 1061-4036

Chromosomes, Human, Pair 1

Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN 1553-7390

Chromosomes, Human, Pair 18

Hafler, J. P. and Maier, L. M. and Cooper, J. D. and Plagnol, V. and Hinks, A. and Simmonds, M. J. and Stevens, H. and Walker, N. and Healy, B. and Howson, J. M. M. and Maisuria, M. and Duley, S. and Coleman, G. and Gough, S. C. L. and Worthington, J. and Kuchroo, V. K. and Wicker, L. S. and Todd, J. A. and IMSGC, . (2009) CD226 Gly307Ser association with multiple autoimmune diseases. Genes and Immunity, 10 (1). pp. 5-10. ISSN 1466-4879

Chromosomes, Human, Pair 20

Heward, J. M. and Simmonds, M. J. and Carr-Smith, J. and Foxall, H. and Franklyn, J. A. and Gough, S. C. L. (2004) A single nucleotide polymorphism in the CD40 gene on chromosome 20q (GD-2) provides no evidence for susceptibility to Graves' disease in UK Caucasians. Clinical Endocrinology, 61 (2). pp. 269-272. ISSN 0300-0664

Chromosomes, Human, Pair 9

Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN 1553-7390

Cluster Analysis

Boelaert, Kristien and Newby, Paul R. and Simmonds, Matthew J. and Holder, Roger L. and Carr-Smith, Jacqueline D. and Heward, Joanne M. and Manji, Nilusha and Allahabadia, Amit and Armitage, Mary and Chatterjee, Krishna V. and Lazarus, John H. and Pearce, Simon H. and Vaidya, Bijay and Gough, Stephen C. and Franklyn, Jayne A. (2010) Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease. American Journal of Medicine, 123 (2). 183.e1-183.e9. ISSN 0002-9343

Cohort Studies

Boelaert, Kristien and Newby, Paul R. and Simmonds, Matthew J. and Holder, Roger L. and Carr-Smith, Jacqueline D. and Heward, Joanne M. and Manji, Nilusha and Allahabadia, Amit and Armitage, Mary and Chatterjee, Krishna V. and Lazarus, John H. and Pearce, Simon H. and Vaidya, Bijay and Gough, Stephen C. and Franklyn, Jayne A. (2010) Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease. American Journal of Medicine, 123 (2). 183.e1-183.e9. ISSN 0002-9343

Brand, O. J. and Barrett, J. C. and Simmonds, M. J. and Newby, P. R. and McCabe, C. J. and Bruce, C. K. and Kysela, B. and Carr-Smith, J. D. and Brix, T. and Hunt, P. J. and Wiersinga, W. M. and Hegedus, L. and Connell, J. and Wass, J. A. H. and Franklyn, J. A. and Weetman, A. P. and Heward, J. M. and Gough, S. C. L. (2009) Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves' disease. Human Molecular Genetics, 18 (9). pp. 1704-1713. ISSN 0964-6906

Chand, S. and Holle, J. U. and Hilhorst, M. and Simmonds, M. J. and Smith, S. and Kamesh, L. and Hewins, P. and McKnight, A. J. and Maxwell, A. P. and Willem Cohen Tervaert, J. and Wieczorek, S. and Harper, L. and Borrows, R. (2013) Caveolin-1 single nucleotide polymorphism in antineutrophil cytoplasmic antibody associated vasculitis. PLoS ONE, 8 (7). ISSN 1932-6203

Heward, J. M. and Simmonds, M. J. and Carr-Smith, J. and Foxall, H. and Franklyn, J. A. and Gough, S. C. L. (2004) A single nucleotide polymorphism in the CD40 gene on chromosome 20q (GD-2) provides no evidence for susceptibility to Graves' disease in UK Caucasians. Clinical Endocrinology, 61 (2). pp. 269-272. ISSN 0300-0664

Moore, J. and McKnight, A.J. and Simmonds, M. J. and Courtney, A. E. and Hanvesakul, R. and Brand, O. J. and Briggs, D. and Ball, S. and Cockwell, P. and Patterson, C.C. and Maxwell, A. P. and Gough, S. C. L. and Borrows, R. (2010) Association of caveolin-1 gene polymorphism with kidney transplant fibrosis and allograft failure. JAMA - Journal of the American Medical Association, 303 (13). pp. 1282-1287. ISSN 0098-7484

Moore, Jason and McKnight, Amy Jayne and Döhler, Bernd and Simmonds, Matthew J. and Courtney, Aisling E. and Brand, Oliver J. and Briggs, David and Ball, Simon and Cockwell, Paul and Patterson, Christopher C. and Maxwell, Alexander P. and Gough, Stephen C. L. and Opelz, Gerhard and Borrows, Richard (2012) Donor ABCB1 variant associates with increased risk for kidney allograft failure. Journal of the American Society of Nephrology, 23 (11). pp. 1891-1899. ISSN 1046-6673

Zeitlin, A. A. and Heward, J. M. and Newby, P. R. and Carr-Smith, J. D. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2008) Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. Genes and Immunity, 9 (4). pp. 358-363. ISSN 1466-4879

Complement System Proteins

Simmonds, Matthew and Gough, S. C. L. (2005) Genetic insights into disease mechanisms of autoimmunity. British Medical Bulletin, 71 (1). pp. 93-113. ISSN 0007-1420

Confidence Intervals

Hafler, J. P. and Maier, L. M. and Cooper, J. D. and Plagnol, V. and Hinks, A. and Simmonds, M. J. and Stevens, H. and Walker, N. and Healy, B. and Howson, J. M. M. and Maisuria, M. and Duley, S. and Coleman, G. and Gough, S. C. L. and Worthington, J. and Kuchroo, V. K. and Wicker, L. S. and Todd, J. A. and IMSGC, . (2009) CD226 Gly307Ser association with multiple autoimmune diseases. Genes and Immunity, 10 (1). pp. 5-10. ISSN 1466-4879

Zeitlin, A. A. and Heward, J. M. and Newby, P. R. and Carr-Smith, J. D. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2008) Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. Genes and Immunity, 9 (4). pp. 358-363. ISSN 1466-4879

Cross-Sectional Studies

Boelaert, Kristien and Newby, Paul R. and Simmonds, Matthew J. and Holder, Roger L. and Carr-Smith, Jacqueline D. and Heward, Joanne M. and Manji, Nilusha and Allahabadia, Amit and Armitage, Mary and Chatterjee, Krishna V. and Lazarus, John H. and Pearce, Simon H. and Vaidya, Bijay and Gough, Stephen C. and Franklyn, Jayne A. (2010) Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease. American Journal of Medicine, 123 (2). 183.e1-183.e9. ISSN 0002-9343

Cyclophilins

Moore, Jason and McKnight, Amy Jayne and Döhler, Bernd and Simmonds, Matthew J. and Courtney, Aisling E. and Brand, Oliver J. and Briggs, David and Ball, Simon and Cockwell, Paul and Patterson, Christopher C. and Maxwell, Alexander P. and Gough, Stephen C. L. and Opelz, Gerhard and Borrows, Richard (2012) Donor ABCB1 variant associates with increased risk for kidney allograft failure. Journal of the American Society of Nephrology, 23 (11). pp. 1891-1899. ISSN 1046-6673

Cytochrome P-450 CYP3A

Moore, Jason and McKnight, Amy Jayne and Döhler, Bernd and Simmonds, Matthew J. and Courtney, Aisling E. and Brand, Oliver J. and Briggs, David and Ball, Simon and Cockwell, Paul and Patterson, Christopher C. and Maxwell, Alexander P. and Gough, Stephen C. L. and Opelz, Gerhard and Borrows, Richard (2012) Donor ABCB1 variant associates with increased risk for kidney allograft failure. Journal of the American Society of Nephrology, 23 (11). pp. 1891-1899. ISSN 1046-6673

DNA

Simmonds, Matthew J. and Heward, J. M. and Carr-Smith, J. and Foxall, H. and Franklyn, J. A. and Gough, S. C. L. (2006) Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease. Journal of Clinical Endocrinology and Metabolism, 91 (3). pp. 1056-1061. ISSN 0021-972X

DNA Primers

Simmonds, Matthew J. and Heward, J. M. and Carr-Smith, J. and Foxall, H. and Franklyn, J. A. and Gough, S. C. L. (2006) Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease. Journal of Clinical Endocrinology and Metabolism, 91 (3). pp. 1056-1061. ISSN 0021-972X

DNA catenation

Nielsen, Christian F. and Huttner, Diana and Bizard, Anna H. and Hirano, Seiki and Li, Tian-Neng and Palmai-Pallag, Timea and Bjerregaard, Victoria A. and Liu, Ying and Nigg, Erich A. and Wang, Lily Hui-Ching and Hickson, Ian D. (2015) PICH promotes sister chromatid disjunction and co-operates with topoisomerase II in mitosis. Nature Communications, 6 . p. 8962. ISSN 2041-1723

DNA determination

Ali, Nadir and Coulson-Thomas, Yvette M. and Norton, Andrew L. and Dixon, Ronald A. and Williams, D. Ross (2013) Announcement of population data: genetic data for 17 Y-STR AmpFℓSTR® Yfiler™ markers from an immigrant Pakistani population in the UK (British Pakistanis). Forensic Science International: Genetics, 7 (2). e40-e42. ISSN 1872-4973

Simmonds, M. J. and Gough, S. C. L. (2004) Unravelling the genetic complexity of autoimmune thyroid disease: HLA, CTLA-4 and beyond. Clinical and Experimental Immunology, 136 (1). pp. 1-10. ISSN 0009-9104

DNA extraction

Ali, Nadir and Coulson-Thomas, Yvette M. and Norton, Andrew L. and Dixon, Ronald A. and Williams, D. Ross (2013) Announcement of population data: genetic data for 17 Y-STR AmpFℓSTR® Yfiler™ markers from an immigrant Pakistani population in the UK (British Pakistanis). Forensic Science International: Genetics, 7 (2). e40-e42. ISSN 1872-4973

Simmonds, Matthew J. and Heward, Joanne M. and Kelly, M. Ann and Allahabadia, Amit and Foxall, Helen and Gordon, Caroline and Franklyn, Jayne A. and Gough, Stephen C. L. (2002) A nonsense mutation in exon 2 of the DNase I gene is not present in UK subjects with systemic lupus erythematosus and Graves' disease: Comment on the article by Rood et al. Arthritis and Rheumatism, 46 (11). pp. 3109-3110. ISSN 0004-3591

DNA polymorphism

Moore, J. and McKnight, A.J. and Simmonds, M. J. and Courtney, A. E. and Hanvesakul, R. and Brand, O. J. and Briggs, D. and Ball, S. and Cockwell, P. and Patterson, C.C. and Maxwell, A. P. and Gough, S. C. L. and Borrows, R. (2010) Association of caveolin-1 gene polymorphism with kidney transplant fibrosis and allograft failure. JAMA - Journal of the American Medical Association, 303 (13). pp. 1282-1287. ISSN 0098-7484

Simmonds, M. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. (2005) The CD40 Kozak SNP: a new susceptibility loci for Graves' disease? Clinical Endocrinology, 63 (2). pp. 232-233. ISSN 0300 0664

Zeitlin, A. A. and Heward, J. M. and Brand, O. J. and Newby, P. R. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2006) Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. Clinical Endocrinology, 65 (3). pp. 380-384. ISSN 0300-0664

DNA repair

Herr, Patrick and Lundin, Cecilia and Evers, Bastiaan and Ebner, Daniel and Bauerschmidt, Christina and Kingham, Guy and Palmai-Pallag, Timea and Mortusewicz, Oliver and Frings, Oliver and Sonnhammer, Erik and Helleday, Thomas (2015) A genome-wide IR-induced RAD51 foci RNAi screen identifies CDC73 involved in chromatin remodeling for DNA repair. Cell Discovery . p. 15034. ISSN 2056-5968

DNA replication

Xing, Meichun and Wang, Xiaohui and Palmai-Pallag, Timea and Shen, Huahao and Helleday, Thomas and Hickson, Ian D. and Ying, Songmin (2015) Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response. Oncotarget, 6 (35). pp. 37638-37646. ISSN 1949-2553

DNA sequence

Simmonds, M. J. and Heward, J.M. and Howson, J.M.M. and Foxall, H. and Nithiyananthan, R. and Franklyn, J.A. and Gough, S.C.L. (2004) A systematic approach to the assesment of known TNF-alpha polymorphisms in Graves' disease. Genes and Immunity, 5 (4). pp. 267-273. ISSN 1466-4879

DNA, article

Elmrghni, Samir and Shaw, Michael and Ali, Nadir and Dixon, Ron and Ross Williams, D. (2012) Aberrations of human gender identification by amelogenin test in Libyans (Benghazi city). Indian Journal of Forensic Medicine and Toxicology, 6 (2). pp. 163-166. ISSN 0973-9122

Simmonds, Matthew J. and Gough, Stephen C. L. (2011) The search for the genetic contribution to autoimmune thyroid disease: The never ending story? Briefings in Functional Genomics, 10 (2). pp. 77-90. ISSN 2041-2649

DSD

Davy, Zowie (2012) Differences in sexual development: towards a phenomenological understanding of gender variance. In: Controversies and Confrontations: Violence and Agency, 6-7 December 2012, University of Vienna, Austria.

Databases, Genetic

Newby, P. R. and Roberts-Davies, E. L. and Brand, O. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2007) Tag SNP screening of the PDCD1 gene for association with Graves' disease. Clinical Endocrinology, 67 (1). pp. 125-128. ISSN 0300-0664

Deoxyribonuclease I

Simmonds, Matthew J. and Heward, Joanne M. and Kelly, M. Ann and Allahabadia, Amit and Foxall, Helen and Gordon, Caroline and Franklyn, Jayne A. and Gough, Stephen C. L. (2002) A nonsense mutation in exon 2 of the DNase I gene is not present in UK subjects with systemic lupus erythematosus and Graves' disease: Comment on the article by Rood et al. Arthritis and Rheumatism, 46 (11). pp. 3109-3110. ISSN 0004-3591

Diabetes Mellitus, Type 1

Hafler, J. P. and Maier, L. M. and Cooper, J. D. and Plagnol, V. and Hinks, A. and Simmonds, M. J. and Stevens, H. and Walker, N. and Healy, B. and Howson, J. M. M. and Maisuria, M. and Duley, S. and Coleman, G. and Gough, S. C. L. and Worthington, J. and Kuchroo, V. K. and Wicker, L. S. and Todd, J. A. and IMSGC, . (2009) CD226 Gly307Ser association with multiple autoimmune diseases. Genes and Immunity, 10 (1). pp. 5-10. ISSN 1466-4879

Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN 1553-7390

Todd, J. A. and Walker, N. M. and Cooper, J. D. and Smyth, D. J. and Downes, K. and Plagnol, V. and Bailey, R. and Nejentsev, S. and Field, S. F. and Payne, F. and Lowe, C. E. and Szeszko, J. S. and Hafler, J. P. and Zeitels, L. and Yang, J. H. M. and Vella, A. and Nutland, S. and Stevens, H. E. and Schuilenburg, H. and Coleman, G. and Maisuria, M. and Meadows, W. and Smink, L. J. and Healy, B. and Burren, O. S. and Lam, A. A. C. and Ovington, N. R. and Allen, J. and Adlem, E. and Leung, H-T. and Wallace, C. and Howson, J. M. M. and Guja, C. and Ionescu-Tırgoviste, C. and Genetics of T1D in Finland, . and Simmonds, M. J. and Heward, J. M. and Gough, S. C. L. and WTCCC, . and Dunger, D. B. and Wicker, L. S. and Clayton, D. G. (2007) Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nature Genetics, 39 (7). pp. 857-864. ISSN 1061-4036

Disease Progression

Yesmin, K. and Hargreaves, C. and Newby, P. R. and Brand, O. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2010) Association of FcGRIIa with Graves' disease: a potential role for dysregulated autoantibody clearance in disease onset/progression. Clinical Endocrinology, 73 (1). pp. 119-125. ISSN 0300-0664

Electronic computers. Computer science

Hudson, John (2011) All watched over by machines of loving grace: part 3 "The monkey in the machine and the machine in the monkey". Digital Imaging and Photography . ISSN UNSPECIFIED

England

Moore, J. and McKnight, A.J. and Simmonds, M. J. and Courtney, A. E. and Hanvesakul, R. and Brand, O. J. and Briggs, D. and Ball, S. and Cockwell, P. and Patterson, C.C. and Maxwell, A. P. and Gough, S. C. L. and Borrows, R. (2010) Association of caveolin-1 gene polymorphism with kidney transplant fibrosis and allograft failure. JAMA - Journal of the American Medical Association, 303 (13). pp. 1282-1287. ISSN 0098-7484

Epigenesis, Genetic

Simmonds, Matthew J. and Benavente, David and Brand, Oliver J. and Moore, Jason and Ball, Simon and Ferro, Charles J. and Briggs, David and Gough, Stephen C. L. and Borrows, Richard J. (2013) Skewing of female X-chromosome inactivation: an epigenetic risk factor for kidney transplantation outcome. Transplantation, 95 (5). e25-e28. ISSN 0041-1337

Epistasis, Genetic

Simmonds, Matthew J. (2013) GWAS in autoimmune thyroid disease: redefining our understanding of pathogenesis. Nature Reviews Endocrinology, 9 (5). pp. 277-287. ISSN 1759-5029

Europe

Chand, S. and Holle, J. U. and Hilhorst, M. and Simmonds, M. J. and Smith, S. and Kamesh, L. and Hewins, P. and McKnight, A. J. and Maxwell, A. P. and Willem Cohen Tervaert, J. and Wieczorek, S. and Harper, L. and Borrows, R. (2013) Caveolin-1 single nucleotide polymorphism in antineutrophil cytoplasmic antibody associated vasculitis. PLoS ONE, 8 (7). ISSN 1932-6203

Hunt, K. A. and Smyth, D. J. and Balschun, T. and Ban, M. and Mistry, V. and Ahmed, T. and Barrett, J. C. and Bhaw-Rosun, L. and Bockett, N. A. and Brand, O. J. and Brouwer, E. and Concannon, P. and Cooper, J. D. and Dias, K-R. M. and van Diemen, C. C. and Dubois, P.C. and Edkins, S. and Fölster-Holst, R. and Fransen, K. and Glass, D. N. and Heap, G. A. R. and Hofmann, S. and Huizinga, T. W. J. and Hunt, S. and Langford, C. and Lee, J. and Mansfield, J. and Giovanna Marrosu, M. and Mathew, C. G. and Mein, C.A. and Müller-Quernheim, J. and Nutland, S. and Onengut-Gumuscu, S. and Ouwehand, W. and Pearce, K. and Prescott, N. and Posthumus, M. D. and Potter, S. and Rosati, G. and Sambrook, J. and Satsangi, J. and Schreiber, S. and Shtir, C. and Simmonds, M. J. and Sudman, M. and Thompson, S. D. and Toes, R. and Trynka, G. and Vyse, T. J. and Walker, N. M. and Weidinger, S. and Zhernakova, A. and Zoledziewska, M. and Weersma, R.K. and Gough, S.C.L. and Sawcer, S. and Wijmenga, C. and Parkes, M. and Cucca, F. and Franke, A. and Deloukas, P. and Rich, S. S. and Todd, J. A. and van Heel, D. A. (2011) Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry. Nature Genetics, 44 (1). pp. 3-5. ISSN 10614036

European Continental Ancestry Group

Brand, O. J. and Barrett, J. C. and Simmonds, M. J. and Newby, P. R. and McCabe, C. J. and Bruce, C. K. and Kysela, B. and Carr-Smith, J. D. and Brix, T. and Hunt, P. J. and Wiersinga, W. M. and Hegedus, L. and Connell, J. and Wass, J. A. H. and Franklyn, J. A. and Weetman, A. P. and Heward, J. M. and Gough, S. C. L. (2009) Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves' disease. Human Molecular Genetics, 18 (9). pp. 1704-1713. ISSN 0964-6906

Heward, J. M. and Simmonds, M. J. and Carr-Smith, J. and Foxall, H. and Franklyn, J. A. and Gough, S. C. L. (2004) A single nucleotide polymorphism in the CD40 gene on chromosome 20q (GD-2) provides no evidence for susceptibility to Graves' disease in UK Caucasians. Clinical Endocrinology, 61 (2). pp. 269-272. ISSN 0300-0664

Hunt, K. A. and Mistry, V. and Bockett, N. A. and Ahmad, T. and Ban, M. and Barker, J. N. and Barrett, J. C. and Blackburn, H. and Brand, O. J. and Burren, O. and Capon, F. and Compston, A. and Gough, S. C. L. and Jostins, L. and Kong, Y. and Lee, J. C. and Lek, M. and MacArthur, D. G. and Mansfield, J. C. and Mathew, C. G. and Mein, C. A. and Mirza, M. and Nutland, S. and Onengut-Gumuscu, S. and Papouli, E. and Parkes, M. and Rich, S. S. and Sawcer, S. and Satsangi, J. and Simmonds, M. J. and Trembath, R. C. and Walker, N. M. and Wozniak, E. and Todd, J. A. and Simpson, M. A. and Plagnol, V. and van Heel, D. A. (2013) Negligible impact of rare autoimmune-locus coding-region variants on missing heritability. Nature, 498 (7453). pp. 232-235. ISSN 0028-0836

Hunt, K. A. and Smyth, D. J. and Balschun, T. and Ban, M. and Mistry, V. and Ahmed, T. and Barrett, J. C. and Bhaw-Rosun, L. and Bockett, N. A. and Brand, O. J. and Brouwer, E. and Concannon, P. and Cooper, J. D. and Dias, K-R. M. and van Diemen, C. C. and Dubois, P.C. and Edkins, S. and Fölster-Holst, R. and Fransen, K. and Glass, D. N. and Heap, G. A. R. and Hofmann, S. and Huizinga, T. W. J. and Hunt, S. and Langford, C. and Lee, J. and Mansfield, J. and Giovanna Marrosu, M. and Mathew, C. G. and Mein, C.A. and Müller-Quernheim, J. and Nutland, S. and Onengut-Gumuscu, S. and Ouwehand, W. and Pearce, K. and Prescott, N. and Posthumus, M. D. and Potter, S. and Rosati, G. and Sambrook, J. and Satsangi, J. and Schreiber, S. and Shtir, C. and Simmonds, M. J. and Sudman, M. and Thompson, S. D. and Toes, R. and Trynka, G. and Vyse, T. J. and Walker, N. M. and Weidinger, S. and Zhernakova, A. and Zoledziewska, M. and Weersma, R.K. and Gough, S.C.L. and Sawcer, S. and Wijmenga, C. and Parkes, M. and Cucca, F. and Franke, A. and Deloukas, P. and Rich, S. S. and Todd, J. A. and van Heel, D. A. (2011) Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry. Nature Genetics, 44 (1). pp. 3-5. ISSN 10614036

Simmonds, M. J. and Heward, J. M. and Barrett, J. C. and Franklyn, J. A. and Gough, S. C. L. (2006) Association of the BTNL2 rs2076530 single nucleotide polymorphism with Graves' disease appears to be secondary to DRB1 exon 2 position beta74. Clinical Endocrinology, 65 (4). pp. 429-432. ISSN 0300-0664

Simmonds, M. J. and Howson, J. M. M. and Heward, J. M. and Carr-Smith, J. and Franklyn, J. A. and Todd, J. A. and Gough, S. C. L. (2007) A novel and major association of HLA-C in Graves' disease that eclipses the classical HLA-DRB1 effect. Human Molecular Genetics, 16 (18). pp. 2149-2153. ISSN 0964-6906

Simmonds, Matthew J. and Brand, Oliver J. and Barrett, Jeffrey C. and Newby, Paul R. and Franklyn, Jayne A. and Gough, Stephen C. L. (2010) Association of Fc receptor-like 5 (FCRL5) with Graves' disease is secondary to the effect of FCRL3. Clinical Endocrinology, 73 (5). pp. 654-660. ISSN 0300-0664

Simmonds, Matthew J. and Heward, J. M. and Carr-Smith, J. and Foxall, H. and Franklyn, J. A. and Gough, S. C. L. (2006) Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease. Journal of Clinical Endocrinology and Metabolism, 91 (3). pp. 1056-1061. ISSN 0021-972X

Zeitlin, A. A. and Heward, J. M. and Newby, P. R. and Carr-Smith, J. D. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2008) Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. Genes and Immunity, 9 (4). pp. 358-363. ISSN 1466-4879

Exons

Hafler, J. P. and Maier, L. M. and Cooper, J. D. and Plagnol, V. and Hinks, A. and Simmonds, M. J. and Stevens, H. and Walker, N. and Healy, B. and Howson, J. M. M. and Maisuria, M. and Duley, S. and Coleman, G. and Gough, S. C. L. and Worthington, J. and Kuchroo, V. K. and Wicker, L. S. and Todd, J. A. and IMSGC, . (2009) CD226 Gly307Ser association with multiple autoimmune diseases. Genes and Immunity, 10 (1). pp. 5-10. ISSN 1466-4879

Hunt, K. A. and Mistry, V. and Bockett, N. A. and Ahmad, T. and Ban, M. and Barker, J. N. and Barrett, J. C. and Blackburn, H. and Brand, O. J. and Burren, O. and Capon, F. and Compston, A. and Gough, S. C. L. and Jostins, L. and Kong, Y. and Lee, J. C. and Lek, M. and MacArthur, D. G. and Mansfield, J. C. and Mathew, C. G. and Mein, C. A. and Mirza, M. and Nutland, S. and Onengut-Gumuscu, S. and Papouli, E. and Parkes, M. and Rich, S. S. and Sawcer, S. and Satsangi, J. and Simmonds, M. J. and Trembath, R. C. and Walker, N. M. and Wozniak, E. and Todd, J. A. and Simpson, M. A. and Plagnol, V. and van Heel, D. A. (2013) Negligible impact of rare autoimmune-locus coding-region variants on missing heritability. Nature, 498 (7453). pp. 232-235. ISSN 0028-0836

Simmonds, M. J. and Heward, J. M. and Barrett, J. C. and Franklyn, J. A. and Gough, S. C. L. (2006) Association of the BTNL2 rs2076530 single nucleotide polymorphism with Graves' disease appears to be secondary to DRB1 exon 2 position beta74. Clinical Endocrinology, 65 (4). pp. 429-432. ISSN 0300-0664

Simmonds, Matthew J. and Heward, Joanne M. and Kelly, M. Ann and Allahabadia, Amit and Foxall, Helen and Gordon, Caroline and Franklyn, Jayne A. and Gough, Stephen C. L. (2002) A nonsense mutation in exon 2 of the DNase I gene is not present in UK subjects with systemic lupus erythematosus and Graves' disease: Comment on the article by Rood et al. Arthritis and Rheumatism, 46 (11). pp. 3109-3110. ISSN 0004-3591

Zeitlin, A. A. and Heward, J. M. and Brand, O. J. and Newby, P. R. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2006) Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. Clinical Endocrinology, 65 (3). pp. 380-384. ISSN 0300-0664

FCLR3 gene

Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN 1553-7390

FCRL1 protein, human

Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN 1553-7390

FCRL3 protein, human

Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN 1553-7390

FCRL5 gene

Simmonds, Matthew J. and Brand, Oliver J. and Barrett, Jeffrey C. and Newby, Paul R. and Franklyn, Jayne A. and Gough, Stephen C. L. (2010) Association of Fc receptor-like 5 (FCRL5) with Graves' disease is secondary to the effect of FCRL3. Clinical Endocrinology, 73 (5). pp. 654-660. ISSN 0300-0664

Fc receptor

Simmonds, Matthew J. and Brand, Oliver J. and Barrett, Jeffrey C. and Newby, Paul R. and Franklyn, Jayne A. and Gough, Stephen C. L. (2010) Association of Fc receptor-like 5 (FCRL5) with Graves' disease is secondary to the effect of FCRL3. Clinical Endocrinology, 73 (5). pp. 654-660. ISSN 0300-0664

Simmonds, Matthew J. and Heward, J. M. and Carr-Smith, J. and Foxall, H. and Franklyn, J. A. and Gough, S. C. L. (2006) Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease. Journal of Clinical Endocrinology and Metabolism, 91 (3). pp. 1056-1061. ISSN 0021-972X

Yesmin, K. and Hargreaves, C. and Newby, P. R. and Brand, O. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2010) Association of FcGRIIa with Graves' disease: a potential role for dysregulated autoantibody clearance in disease onset/progression. Clinical Endocrinology, 73 (1). pp. 119-125. ISSN 0300-0664

Fc receptor IIa

Yesmin, K. and Hargreaves, C. and Newby, P. R. and Brand, O. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2010) Association of FcGRIIa with Graves' disease: a potential role for dysregulated autoantibody clearance in disease onset/progression. Clinical Endocrinology, 73 (1). pp. 119-125. ISSN 0300-0664

Fc receptor IIa, antibody production

Yesmin, K. and Hargreaves, C. and Newby, P. R. and Brand, O. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2010) Association of FcGRIIa with Graves' disease: a potential role for dysregulated autoantibody clearance in disease onset/progression. Clinical Endocrinology, 73 (1). pp. 119-125. ISSN 0300-0664

Fc receptor like 3

Simmonds, Matthew J. and Brand, Oliver J. and Barrett, Jeffrey C. and Newby, Paul R. and Franklyn, Jayne A. and Gough, Stephen C. L. (2010) Association of Fc receptor-like 5 (FCRL5) with Graves' disease is secondary to the effect of FCRL3. Clinical Endocrinology, 73 (5). pp. 654-660. ISSN 0300-0664

Gene Dosage

Simmonds, Matthew J. (2013) GWAS in autoimmune thyroid disease: redefining our understanding of pathogenesis. Nature Reviews Endocrinology, 9 (5). pp. 277-287. ISSN 1759-5029

Gene Frequency

Hafler, J. P. and Maier, L. M. and Cooper, J. D. and Plagnol, V. and Hinks, A. and Simmonds, M. J. and Stevens, H. and Walker, N. and Healy, B. and Howson, J. M. M. and Maisuria, M. and Duley, S. and Coleman, G. and Gough, S. C. L. and Worthington, J. and Kuchroo, V. K. and Wicker, L. S. and Todd, J. A. and IMSGC, . (2009) CD226 Gly307Ser association with multiple autoimmune diseases. Genes and Immunity, 10 (1). pp. 5-10. ISSN 1466-4879

Heward, J. M. and Simmonds, M. J. and Carr-Smith, J. and Foxall, H. and Franklyn, J. A. and Gough, S. C. L. (2004) A single nucleotide polymorphism in the CD40 gene on chromosome 20q (GD-2) provides no evidence for susceptibility to Graves' disease in UK Caucasians. Clinical Endocrinology, 61 (2). pp. 269-272. ISSN 0300-0664

Hunt, K. A. and Mistry, V. and Bockett, N. A. and Ahmad, T. and Ban, M. and Barker, J. N. and Barrett, J. C. and Blackburn, H. and Brand, O. J. and Burren, O. and Capon, F. and Compston, A. and Gough, S. C. L. and Jostins, L. and Kong, Y. and Lee, J. C. and Lek, M. and MacArthur, D. G. and Mansfield, J. C. and Mathew, C. G. and Mein, C. A. and Mirza, M. and Nutland, S. and Onengut-Gumuscu, S. and Papouli, E. and Parkes, M. and Rich, S. S. and Sawcer, S. and Satsangi, J. and Simmonds, M. J. and Trembath, R. C. and Walker, N. M. and Wozniak, E. and Todd, J. A. and Simpson, M. A. and Plagnol, V. and van Heel, D. A. (2013) Negligible impact of rare autoimmune-locus coding-region variants on missing heritability. Nature, 498 (7453). pp. 232-235. ISSN 0028-0836

Newby, P. R. and Roberts-Davies, E. L. and Brand, O. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2007) Tag SNP screening of the PDCD1 gene for association with Graves' disease. Clinical Endocrinology, 67 (1). pp. 125-128. ISSN 0300-0664

Zeitlin, A. A. and Heward, J. M. and Brand, O. J. and Newby, P. R. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2006) Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. Clinical Endocrinology, 65 (3). pp. 380-384. ISSN 0300-0664

Gene-Environment Interaction

Simmonds, Matthew J. (2013) GWAS in autoimmune thyroid disease: redefining our understanding of pathogenesis. Nature Reviews Endocrinology, 9 (5). pp. 277-287. ISSN 1759-5029

Genes, MHC Class II

Simmonds, Matthew J. and Howson, Joanna M. M. and Heward, Joanne M. and Cordell, Heather J. and Foxall, Helen and Carr-Smith, Jackie and Gibson, Sarah M. and Walker, Neil and Tomer, Yaron and Franklyn, Jayne A. and Todd, John A. and Gough, Stephen C. L. (2005) Regression mapping of association between the human leukocyte antigen region and Graves' disease. American Journal of Human Genetics, 76 (1). pp. 157-163. ISSN 0002-9297

Genetic Association Studies

Hunt, K. A. and Smyth, D. J. and Balschun, T. and Ban, M. and Mistry, V. and Ahmed, T. and Barrett, J. C. and Bhaw-Rosun, L. and Bockett, N. A. and Brand, O. J. and Brouwer, E. and Concannon, P. and Cooper, J. D. and Dias, K-R. M. and van Diemen, C. C. and Dubois, P.C. and Edkins, S. and Fölster-Holst, R. and Fransen, K. and Glass, D. N. and Heap, G. A. R. and Hofmann, S. and Huizinga, T. W. J. and Hunt, S. and Langford, C. and Lee, J. and Mansfield, J. and Giovanna Marrosu, M. and Mathew, C. G. and Mein, C.A. and Müller-Quernheim, J. and Nutland, S. and Onengut-Gumuscu, S. and Ouwehand, W. and Pearce, K. and Prescott, N. and Posthumus, M. D. and Potter, S. and Rosati, G. and Sambrook, J. and Satsangi, J. and Schreiber, S. and Shtir, C. and Simmonds, M. J. and Sudman, M. and Thompson, S. D. and Toes, R. and Trynka, G. and Vyse, T. J. and Walker, N. M. and Weidinger, S. and Zhernakova, A. and Zoledziewska, M. and Weersma, R.K. and Gough, S.C.L. and Sawcer, S. and Wijmenga, C. and Parkes, M. and Cucca, F. and Franke, A. and Deloukas, P. and Rich, S. S. and Todd, J. A. and van Heel, D. A. (2011) Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry. Nature Genetics, 44 (1). pp. 3-5. ISSN 10614036

Moore, Jason and McKnight, Amy Jayne and Döhler, Bernd and Simmonds, Matthew J. and Courtney, Aisling E. and Brand, Oliver J. and Briggs, David and Ball, Simon and Cockwell, Paul and Patterson, Christopher C. and Maxwell, Alexander P. and Gough, Stephen C. L. and Opelz, Gerhard and Borrows, Richard (2012) Donor ABCB1 variant associates with increased risk for kidney allograft failure. Journal of the American Society of Nephrology, 23 (11). pp. 1891-1899. ISSN 1046-6673

Genetic Loci

Cooper, J. D. and Simmonds, M. J. and Walker, N.M. and Burren, O. and Brand, O.J. and Guo, H. and Wallace, C. and Stevens, H. and Coleman, G and Franklyn, J.A. and Todd, J.A. and Gough, S.C.L. (2012) Seven newly identified loci for autoimmune thyroid disease. Human Molecular Genetics, 21 (23). pp. 5202-5208. ISSN 0964-6906

Medici, M. and Porcu, E. and Pistis, G. and Teumer, A. and Brown, S. J. and Jensen, R. A. and Rawal, R. and Roef, G. L. and Plantinga, T. S. and Vermeulen, S. H. and Lahti, J. and Simmonds, M. J. and Husemoen, L. N. N. and Freathy, R. M. and Shields, B. M. and Pietzner, D. and Nagy, R. and Broer, L. and Chaker, L. and Korevaar, T. I. M. and Plia, M. G. and Sala, C. and Volker, U. and Richards, J. B. and Sweep, F. C. and Gieger, C. and Corre, T. and Kajantie, E. and Thuesen, B. and Taes, Y. E. and Visser, W. E. and Hattersley, A. T. and Kratzsch, J. and Hamilton, A. and Li, W. and Homuth, G. and Lobina, M. and Mariotti, S. and Soranzo, N. and Cocca, M. and Nauck, M. and Spielhagen, C. and Ross, A. and Arnold, A. and van de Bunt, M. and Liyanarachchi, S. and Heier, M. and Grabe, H. J. and Masciullo, C. and Galesloot, T. E. and Lim, E. M. and Reischl, E. and Leedman, P. J. and Lai, S. and Delitala, A. and Bremner, A. P. and Philips, D. I. W. and Beilby, J. P. and Mulas, A. and Vocale, M. and Abecasis, G. and Forsen, T. and James, A. and Widen, E. and Hui, J. and Prokisch, H. and Rietzschel, E. E. and Palotie, A. and Feddema, P. and Fletcher, S. J. and Schramm, K. and Rotter, J. I. and Kluttig, A. and Radke, D. and Traglia, M. and Surdulescu, G. L. and He, H. and Franklyn, J. A. and Tiller, D. and Vaidya, B. and de Meyer, T. and Jørgensen, T. and Eriksson, J. G. and O’Leary, P. C. and Wichmann, E. and Hermus, A. R. and Psaty, B. M. and Ittermann, T. and Hofman, A. and Bosi, E. and Schlessinger, D. and Wallaschofski, H. and Pirastu, N. and Aulchenko, Y.S. and de la Chapelle, A. and Netea-Maier, R.T. and Gough, S.C.L. and Meyer zu Schwabedissen, H. and Frayling, T.M. and Kaufman, J.M. and Linneberg, A. and Raikkonen, K. and Smit, J.W.A. and Kiemeney, L.A. and Rivadeneira, F. and Uitterlinden, A.G. and Walsh, J.P. and Meisinger, C. and den Heijer, M. and Visser, T.J. and Spector, T.D. and Wilson, S.G. and Volzke, H. and Cappola, A. and Toniolo, D. and Sanna, S. and Naitza, S. and Peeters, R.P. (2014) Identification of novel genetic loci associated with thyroid peroxidase antibodies and clinical thyroid disease. PLoS Genetics, 10 (2). ISSN 15537390

Simmonds, Matthew J. (2013) GWAS in autoimmune thyroid disease: redefining our understanding of pathogenesis. Nature Reviews Endocrinology, 9 (5). pp. 277-287. ISSN 1759-5029

Genetic Predisposition to Disease

Boelaert, Kristien and Newby, Paul R. and Simmonds, Matthew J. and Holder, Roger L. and Carr-Smith, Jacqueline D. and Heward, Joanne M. and Manji, Nilusha and Allahabadia, Amit and Armitage, Mary and Chatterjee, Krishna V. and Lazarus, John H. and Pearce, Simon H. and Vaidya, Bijay and Gough, Stephen C. and Franklyn, Jayne A. (2010) Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease. American Journal of Medicine, 123 (2). 183.e1-183.e9. ISSN 0002-9343

Chand, S. and Holle, J. U. and Hilhorst, M. and Simmonds, M. J. and Smith, S. and Kamesh, L. and Hewins, P. and McKnight, A. J. and Maxwell, A. P. and Willem Cohen Tervaert, J. and Wieczorek, S. and Harper, L. and Borrows, R. (2013) Caveolin-1 single nucleotide polymorphism in antineutrophil cytoplasmic antibody associated vasculitis. PLoS ONE, 8 (7). ISSN 1932-6203

Cooper, J. D. and Simmonds, M. J. and Walker, N.M. and Burren, O. and Brand, O.J. and Guo, H. and Wallace, C. and Stevens, H. and Coleman, G and Franklyn, J.A. and Todd, J.A. and Gough, S.C.L. (2012) Seven newly identified loci for autoimmune thyroid disease. Human Molecular Genetics, 21 (23). pp. 5202-5208. ISSN 0964-6906

Hafler, J. P. and Maier, L. M. and Cooper, J. D. and Plagnol, V. and Hinks, A. and Simmonds, M. J. and Stevens, H. and Walker, N. and Healy, B. and Howson, J. M. M. and Maisuria, M. and Duley, S. and Coleman, G. and Gough, S. C. L. and Worthington, J. and Kuchroo, V. K. and Wicker, L. S. and Todd, J. A. and IMSGC, . (2009) CD226 Gly307Ser association with multiple autoimmune diseases. Genes and Immunity, 10 (1). pp. 5-10. ISSN 1466-4879

Heward, J. M. and Simmonds, M. J. and Carr-Smith, J. and Foxall, H. and Franklyn, J. A. and Gough, S. C. L. (2004) A single nucleotide polymorphism in the CD40 gene on chromosome 20q (GD-2) provides no evidence for susceptibility to Graves' disease in UK Caucasians. Clinical Endocrinology, 61 (2). pp. 269-272. ISSN 0300-0664

Hunt, K. A. and Mistry, V. and Bockett, N. A. and Ahmad, T. and Ban, M. and Barker, J. N. and Barrett, J. C. and Blackburn, H. and Brand, O. J. and Burren, O. and Capon, F. and Compston, A. and Gough, S. C. L. and Jostins, L. and Kong, Y. and Lee, J. C. and Lek, M. and MacArthur, D. G. and Mansfield, J. C. and Mathew, C. G. and Mein, C. A. and Mirza, M. and Nutland, S. and Onengut-Gumuscu, S. and Papouli, E. and Parkes, M. and Rich, S. S. and Sawcer, S. and Satsangi, J. and Simmonds, M. J. and Trembath, R. C. and Walker, N. M. and Wozniak, E. and Todd, J. A. and Simpson, M. A. and Plagnol, V. and van Heel, D. A. (2013) Negligible impact of rare autoimmune-locus coding-region variants on missing heritability. Nature, 498 (7453). pp. 232-235. ISSN 0028-0836

Hunt, K. A. and Smyth, D. J. and Balschun, T. and Ban, M. and Mistry, V. and Ahmed, T. and Barrett, J. C. and Bhaw-Rosun, L. and Bockett, N. A. and Brand, O. J. and Brouwer, E. and Concannon, P. and Cooper, J. D. and Dias, K-R. M. and van Diemen, C. C. and Dubois, P.C. and Edkins, S. and Fölster-Holst, R. and Fransen, K. and Glass, D. N. and Heap, G. A. R. and Hofmann, S. and Huizinga, T. W. J. and Hunt, S. and Langford, C. and Lee, J. and Mansfield, J. and Giovanna Marrosu, M. and Mathew, C. G. and Mein, C.A. and Müller-Quernheim, J. and Nutland, S. and Onengut-Gumuscu, S. and Ouwehand, W. and Pearce, K. and Prescott, N. and Posthumus, M. D. and Potter, S. and Rosati, G. and Sambrook, J. and Satsangi, J. and Schreiber, S. and Shtir, C. and Simmonds, M. J. and Sudman, M. and Thompson, S. D. and Toes, R. and Trynka, G. and Vyse, T. J. and Walker, N. M. and Weidinger, S. and Zhernakova, A. and Zoledziewska, M. and Weersma, R.K. and Gough, S.C.L. and Sawcer, S. and Wijmenga, C. and Parkes, M. and Cucca, F. and Franke, A. and Deloukas, P. and Rich, S. S. and Todd, J. A. and van Heel, D. A. (2011) Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry. Nature Genetics, 44 (1). pp. 3-5. ISSN 10614036

Moore, J. and McKnight, A.J. and Simmonds, M. J. and Courtney, A. E. and Hanvesakul, R. and Brand, O. J. and Briggs, D. and Ball, S. and Cockwell, P. and Patterson, C.C. and Maxwell, A. P. and Gough, S. C. L. and Borrows, R. (2010) Association of caveolin-1 gene polymorphism with kidney transplant fibrosis and allograft failure. JAMA - Journal of the American Medical Association, 303 (13). pp. 1282-1287. ISSN 0098-7484

Simmonds, M. J. and Gough, S. C. L. (2004) Unravelling the genetic complexity of autoimmune thyroid disease: HLA, CTLA-4 and beyond. Clinical and Experimental Immunology, 136 (1). pp. 1-10. ISSN 0009-9104

Simmonds, M. J. and Heward, J. M. and Barrett, J. C. and Franklyn, J. A. and Gough, S. C. L. (2006) Association of the BTNL2 rs2076530 single nucleotide polymorphism with Graves' disease appears to be secondary to DRB1 exon 2 position beta74. Clinical Endocrinology, 65 (4). pp. 429-432. ISSN 0300-0664

Simmonds, M. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. (2005) The CD40 Kozak SNP: a new susceptibility loci for Graves' disease? Clinical Endocrinology, 63 (2). pp. 232-233. ISSN 0300 0664

Simmonds, M. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. (2005) IL-13 and chromosome 5q31-q33: problems of identifying association within regions of linkage to Graves' disease. Clinical Endocrinology, 63 (6). pp. 695-697. ISSN 0300-0664

Simmonds, Matthew J. (2013) GWAS in autoimmune thyroid disease: redefining our understanding of pathogenesis. Nature Reviews Endocrinology, 9 (5). pp. 277-287. ISSN 1759-5029

Simmonds, Matthew J. and Brand, Oliver J. and Barrett, Jeffrey C. and Newby, Paul R. and Franklyn, Jayne A. and Gough, Stephen C. L. (2010) Association of Fc receptor-like 5 (FCRL5) with Graves' disease is secondary to the effect of FCRL3. Clinical Endocrinology, 73 (5). pp. 654-660. ISSN 0300-0664

Simmonds, Matthew J. and Gough, Stephen C. L. (2011) The search for the genetic contribution to autoimmune thyroid disease: The never ending story? Briefings in Functional Genomics, 10 (2). pp. 77-90. ISSN 2041-2649

Simmonds, Matthew J. and Heward, Joanne M. and Kelly, M. Ann and Allahabadia, Amit and Foxall, Helen and Gordon, Caroline and Franklyn, Jayne A. and Gough, Stephen C. L. (2002) A nonsense mutation in exon 2 of the DNase I gene is not present in UK subjects with systemic lupus erythematosus and Graves' disease: Comment on the article by Rood et al. Arthritis and Rheumatism, 46 (11). pp. 3109-3110. ISSN 0004-3591

Todd, J. A. and Walker, N. M. and Cooper, J. D. and Smyth, D. J. and Downes, K. and Plagnol, V. and Bailey, R. and Nejentsev, S. and Field, S. F. and Payne, F. and Lowe, C. E. and Szeszko, J. S. and Hafler, J. P. and Zeitels, L. and Yang, J. H. M. and Vella, A. and Nutland, S. and Stevens, H. E. and Schuilenburg, H. and Coleman, G. and Maisuria, M. and Meadows, W. and Smink, L. J. and Healy, B. and Burren, O. S. and Lam, A. A. C. and Ovington, N. R. and Allen, J. and Adlem, E. and Leung, H-T. and Wallace, C. and Howson, J. M. M. and Guja, C. and Ionescu-Tırgoviste, C. and Genetics of T1D in Finland, . and Simmonds, M. J. and Heward, J. M. and Gough, S. C. L. and WTCCC, . and Dunger, D. B. and Wicker, L. S. and Clayton, D. G. (2007) Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nature Genetics, 39 (7). pp. 857-864. ISSN 1061-4036

Yesmin, K. and Hargreaves, C. and Newby, P. R. and Brand, O. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2010) Association of FcGRIIa with Graves' disease: a potential role for dysregulated autoantibody clearance in disease onset/progression. Clinical Endocrinology, 73 (1). pp. 119-125. ISSN 0300-0664

Zeitlin, A. A. and Heward, J. M. and Brand, O. J. and Newby, P. R. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2006) Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. Clinical Endocrinology, 65 (3). pp. 380-384. ISSN 0300-0664

Zeitlin, A. A. and Heward, J. M. and Newby, P. R. and Carr-Smith, J. D. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2008) Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. Genes and Immunity, 9 (4). pp. 358-363. ISSN 1466-4879

Genetic Variation

Hunt, K. A. and Mistry, V. and Bockett, N. A. and Ahmad, T. and Ban, M. and Barker, J. N. and Barrett, J. C. and Blackburn, H. and Brand, O. J. and Burren, O. and Capon, F. and Compston, A. and Gough, S. C. L. and Jostins, L. and Kong, Y. and Lee, J. C. and Lek, M. and MacArthur, D. G. and Mansfield, J. C. and Mathew, C. G. and Mein, C. A. and Mirza, M. and Nutland, S. and Onengut-Gumuscu, S. and Papouli, E. and Parkes, M. and Rich, S. S. and Sawcer, S. and Satsangi, J. and Simmonds, M. J. and Trembath, R. C. and Walker, N. M. and Wozniak, E. and Todd, J. A. and Simpson, M. A. and Plagnol, V. and van Heel, D. A. (2013) Negligible impact of rare autoimmune-locus coding-region variants on missing heritability. Nature, 498 (7453). pp. 232-235. ISSN 0028-0836

Hunt, K. A. and Smyth, D. J. and Balschun, T. and Ban, M. and Mistry, V. and Ahmed, T. and Barrett, J. C. and Bhaw-Rosun, L. and Bockett, N. A. and Brand, O. J. and Brouwer, E. and Concannon, P. and Cooper, J. D. and Dias, K-R. M. and van Diemen, C. C. and Dubois, P.C. and Edkins, S. and Fölster-Holst, R. and Fransen, K. and Glass, D. N. and Heap, G. A. R. and Hofmann, S. and Huizinga, T. W. J. and Hunt, S. and Langford, C. and Lee, J. and Mansfield, J. and Giovanna Marrosu, M. and Mathew, C. G. and Mein, C.A. and Müller-Quernheim, J. and Nutland, S. and Onengut-Gumuscu, S. and Ouwehand, W. and Pearce, K. and Prescott, N. and Posthumus, M. D. and Potter, S. and Rosati, G. and Sambrook, J. and Satsangi, J. and Schreiber, S. and Shtir, C. and Simmonds, M. J. and Sudman, M. and Thompson, S. D. and Toes, R. and Trynka, G. and Vyse, T. J. and Walker, N. M. and Weidinger, S. and Zhernakova, A. and Zoledziewska, M. and Weersma, R.K. and Gough, S.C.L. and Sawcer, S. and Wijmenga, C. and Parkes, M. and Cucca, F. and Franke, A. and Deloukas, P. and Rich, S. S. and Todd, J. A. and van Heel, D. A. (2011) Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry. Nature Genetics, 44 (1). pp. 3-5. ISSN 10614036

Genetic variation

Taal, H. Rob and St Pourcain, Beate and Thiering, Elisabeth and Das, Shikta and Mook-Kanamori, Dennis O. and Warrington, Nicole M. and Kaakinen, Marika and Kreiner-Møller, Eskil and Bradfield, Jonathan P. and Freathy, Rachel M. and Geller, Frank and Guxens, Mònica and Cousminer, Diana L. and Kerkhof, Marjan and Timpson, Nicholas J. and Ikram, M. Arfan and Beilin, Lawrence J. and Bønnelykke, Klaus and Buxton, Jessica L. and Charoen, Pimphen and Chawes, Bo Lund Krogsgaard and Eriksson, Johan and Evans, David M. and Hofman, Albert and Kemp, John P. and Kim, Cecilia E. and Klopp, Norman and Lahti, Jari and Lye, Stephen J. and McMahon, George and Mentch, Frank D. and Müller-Nurasyid, Martina and O'Reilly, Paul F. and Prokopenko, Inga and Rivadeneira, Fernando and Steegers, Eric A. P. and Sunyer, Jordi and Tiesler, Carla and Yaghootkar, Hanieh and Fornage, Myriam and Smith, Albert V. and Seshadri, Sudha and Schmidt, Reinhold and Debette, Stéphanie and Vrooman, Henri A. and Sigurdsson, Sigurdur and Ropele, Stefan and Coker, Laura H. and Longstreth, W. T. and Niessen, Wiro J. and DeStefano, Anita L. and Beiser, Alexa and Zijdenbos, Alex P. and Struchalin, Maksim and Jack, Clifford R. and Nalls, Mike A. and Au, Rhoda and Gudnason, Haukur and van der Lugt, Aad and Harris, Tamara B. and Meeks, William M. and Vernooij, Meike W. and van Buchem, Mark A. and Catellier, Diane and Gudnason, Vilmundur and Windham, B. Gwen and Wolf, Philip A. and van Duijn, Cornelia M. and Mosley, Thomas H. and Schmidt, Helena and Launer, Lenore J. and Breteler, Monique M. B. and DeCarli, Charles and Mosley, Thomas and Ang, Wei and van Beijsterveldt, Toos and Bergen, Nienke and Benke, Kelly and Berry, Diane and Coin, Lachlan and Elliott, Paul and Frayling, Tim and Gaillard, Romy and Groen-Blokhuis, Maria and Hadley, Dexter and Hottenga, Jouke Jan and Huikari, Ville and Hypponen, Elina and Kowgier, Matthew and Lawlor, Debbie A. and Lewin, Alex and Lindgren, Cecilia and Marsh, Julie and Middeldorp, Christel and Millwood, Iona and Nivard, Michel and Palmer, Lyle J. and Rodriguez, Alina and Sebert, Sylvain and Standl, Marie and Strachan, David P. and Uitterlinden, Andre G. and Valcárcel, Beatriz and White, Scott and Willemsen, Gonneke and Boomsma, Dorret I. and Grant, Struan F. A. and Hakonarson, Hakon and Hattersley, Andrew T. and Heinrich, Joachim and Jaddoe, Vincent W. V. and McCarthy, Mark I. and Pennell, Craig E. and Power, Chris and Widen, Elisabeth and Blakemore, Alexandra I. F. and Chiavacci, Rosetta M. and Feenstra, Bjarke and Fernandez-Banet, Julio and Hartikainen, Anna-Liisa and van der Heijden, Albert J. and Iñiguez, Carmen and Lathrop, Mark and McArdle, Wendy L. and Mølgaard, Anne and Newnham, John P. and Palotie, Aarno and Pouta, Annneli and Ring, Susan M. and Sovio, Ulla and Wichmann, H-Erich and Vissing, Nadja Hawwa and van Duijn, Cornelia M. and Koppelman, Gerard H. and Melbye, Mads and Bisgaard, Hans and Smith, George Davey and Adair, Linda S. and Atalay, Mustafa and Davis, Oliver S. P. and Flexeder, Claudia and Goh, Liang-Kee and Haworth, Claire M. A. and Hedebrand, Johannes and Hinney, Anke and Hirschhorn, Joel N. and Holloway, John W. and Holst, Claus and Horikoshi, Momoko and Kilpeläinen, Tuomas O. and Kirin, Mirna and Lakka, Hanna-Maaria and Lange, Leslie A. and Lehtimäki, Terho and Lindi, Virpi and Maggi, Reedik and Murray, Jeffrey C. and Nohr, Ellen Aagaard and Ntalla, Ioanna and Oken, Emily and Panoutsopoulou, Kalliope and Pararajasingham, Jennifer and Salem, Rany M. and Siitonen, Niina and Teo, Yik-Ying and Zeggini, Eleftheria and Cooper, Cyrus and Estivill, Xavier and Gillman, Matthew and Hocher, Berthold and Jarvelin, Marjo-Riitta and Lakka, Timo A. and Mohlke, Karen L. and Dedoussis, George V. and Ong, Ken K. and Pearson, Ewan R. and Price, Thomas S. and Raitakari, Olli T. and Saw, Seang-Mei and Scherag, Andre and Simell, Olli and Sørensen, Thorkild I. A. and Wilson, James F. (2012) Common variants at 12q15 and 12q24 are associated with infant head circumference. Nature Genetics, 44 (5). pp. 532-538. ISSN 1061-4036

Genetics

Ali, Nadir and Coulson-Thomas, Yvette M. and Dixon, Ronald A. and Williams, D. Ross (2014) Genetic variation comparison of 15 autosomal STR loci in an immigrant population living in the UK (British Pakistanis) with an ancestral origin population from Pakistan. Forensic Science International: Genetics, 9 . e10-e12. ISSN 1872-4973

Hamilton, Alexander and Gough, Stephen C. L. and Simmonds, Matthew J. (2013) Genetics of Graves’ disease. In: eLS - Encyclopedia of Life Sciences. Wiley. ISBN 9780470015902

Ikram, M. Arfan and Fornage, Myriam and Smith, Albert V. and Seshadri, Sudha and Schmidt, Reinhold and Debette, Stéphanie and Vrooman, Henri A. and Sigurdsson, Sigurdur and Ropele, Stefan and Taal, H. Rob and Mook-Kanamori, Dennis O. and Coker, Laura H. and Longstreth, W. T. and Niessen, Wiro J. and DeStefano, Anita L. and Beiser, Alexa and Zijdenbos, Alex P. and Struchalin, Maksim and Jack, Clifford R. and Rivadeneira, Fernando and Uitterlinden, Andre G. and Knopman, David S. and Hartikainen, Anna-Liisa and Pennell, Craig E. and Thiering, Elisabeth and Steegers, Eric A. P. and Hakonarson, Hakon and Heinrich, Joachim and Palmer, Lyle J. and Jarvelin, Marjo-Riitta and McCarthy, Mark I. and Grant, Struan F. A. and Pourcain, Beate St and Timpson, Nicholas J. and Smith, George Davey and Sovio, Ulla and Nalls, Mike A. and Au, Rhoda and Hofman, Albert and Gudnason, Haukur and van der Lugt, Aad and Harris, Tamara B. and Meeks, William M. and Vernooij, Meike W. and van Buchem, Mark A. and Catellier, Diane and Jaddoe, Vincent W. V. and Gudnason, Vilmundur and Windham, B. Gwen and Wolf, Philip A. and van Duijn, Cornelia M. and Mosley, Thomas H. and Schmidt, Helena and Launer, Lenore J. and Breteler, Monique M. B. and DeCarli, Charles and Adair, Linda S. and Ang, Wei and Atalay, Mustafa and van Beijsterveldt, Toos and Bergen, Nienke and Benke, Kelly and Berry, Diane and Coin, Lachlan and Davis, Oliver S. P. and Elliott, Paul and Flexeder, Claudia and Frayling, Tim and Gaillard, Romy and Groen-Blokhuis, Maria and Goh, Liang-Kee and Haworth, Claire M. A. and Hadley, Dexter and Hedebrand, Johannes and Hinney, Anke and Hirschhorn, Joel N. and Holloway, John W. and Holst, Claus and Jan Hottenga, Jouke and Horikoshi, Momoko and Huikari, Ville and Hypponen, Elina and Kilpeläinen, Tuomas O. and Kirin, Mirna and Kowgier, Matthew and Lakka, Hanna-Maaria and Lange, Leslie A. and Lawlor, Debbie A. and Lehtimäki, Terho and Lewin, Alex and Lindgren, Cecilia and Lindi, Virpi and Maggi, Reedik and Marsh, Julie and Middeldorp, Christel and Millwood, Iona and Murray, Jeffrey C. and Nivard, Michel and Nohr, Ellen Aagaard and Ntalla, Ioanna and Oken, Emily and Panoutsopoulou, Kalliope and Pararajasingham, Jennifer and Rodriguez, Alina and Salem, Rany M. and Sebert, Sylvain and Siitonen, Niina and Strachan, David P. and Teo, Yik-Ying and Valcárcel, Beatriz and Willemsen, Gonneke and Zeggini, Eleftheria and Boomsma, Dorret I. and Cooper, Cyrus and Gillman, Matthew and Hocher, Berthold and Lakka, Timo A. and Mohlke, Karen L. and Dedoussis, George V. and Ong, Ken K. and Pearson, Ewan R. and Price, Thomas S. and Power, Chris and Raitakari, Olli T. and Saw, Seang-Mei and Scherag, Andre and Simell, Olli and Sørensen, Thorkild I. A. and Wilson, James F. (2012) Common variants at 6q22 and 17q21 are associated with intracranial volume. Nature Genetics, 44 (5). pp. 539-544. ISSN 1061-4036

Kilarski, Laura L. and Rutten-Jacobs, Loes C. A. and Bevan, Stephen and Baker, Rob and Hassan, Ahamad and Hughes, Derralynn A. and Markus, Hugh S. (2015) Prevalence of CADASIL and Fabry disease in a cohort of MRI defined younger onset lacunar stroke. PloS one, 10 (8). e0136352. ISSN 1932-6203

St Pourcain, Beate and Cents, Rolieke A. M. and Whitehouse, Andrew J. O. and Haworth, Claire M. A. and Davis, Oliver S. P. and O’Reilly, Paul F. and Roulstone, Susan and Wren, Yvonne and Ang, Qi W. and Velders, Fleur P. and Evans, David M. and Kemp, John P. and Warrington, Nicole M. and Miller, Laura and Timpson, Nicholas J. and Ring, Susan M. and Verhulst, Frank C. and Hofman, Albert and Rivadeneira, Fernando and Meaburn, Emma L. and Price, Thomas S. and Dale, Philip S. and Pillas, Demetris and Yliherva, Anneli and Rodriguez, Alina and Golding, Jean and Jaddoe, Vincent W. V. and Jarvelin, Marjo-Riitta and Plomin, Robert and Pennell, Craig E. and Tiemeier, Henning and Davey Smith, George (2014) Common variation near ROBO2 is associated with expressive vocabulary in infancy. Nature Communications, 5 . p. 4831. ISSN 2041-1723

Taal, H. Rob and St Pourcain, Beate and Thiering, Elisabeth and Das, Shikta and Mook-Kanamori, Dennis O. and Warrington, Nicole M. and Kaakinen, Marika and Kreiner-Møller, Eskil and Bradfield, Jonathan P. and Freathy, Rachel M. and Geller, Frank and Guxens, Mònica and Cousminer, Diana L. and Kerkhof, Marjan and Timpson, Nicholas J. and Ikram, M. Arfan and Beilin, Lawrence J. and Bønnelykke, Klaus and Buxton, Jessica L. and Charoen, Pimphen and Chawes, Bo Lund Krogsgaard and Eriksson, Johan and Evans, David M. and Hofman, Albert and Kemp, John P. and Kim, Cecilia E. and Klopp, Norman and Lahti, Jari and Lye, Stephen J. and McMahon, George and Mentch, Frank D. and Müller-Nurasyid, Martina and O'Reilly, Paul F. and Prokopenko, Inga and Rivadeneira, Fernando and Steegers, Eric A. P. and Sunyer, Jordi and Tiesler, Carla and Yaghootkar, Hanieh and Fornage, Myriam and Smith, Albert V. and Seshadri, Sudha and Schmidt, Reinhold and Debette, Stéphanie and Vrooman, Henri A. and Sigurdsson, Sigurdur and Ropele, Stefan and Coker, Laura H. and Longstreth, W. T. and Niessen, Wiro J. and DeStefano, Anita L. and Beiser, Alexa and Zijdenbos, Alex P. and Struchalin, Maksim and Jack, Clifford R. and Nalls, Mike A. and Au, Rhoda and Gudnason, Haukur and van der Lugt, Aad and Harris, Tamara B. and Meeks, William M. and Vernooij, Meike W. and van Buchem, Mark A. and Catellier, Diane and Gudnason, Vilmundur and Windham, B. Gwen and Wolf, Philip A. and van Duijn, Cornelia M. and Mosley, Thomas H. and Schmidt, Helena and Launer, Lenore J. and Breteler, Monique M. B. and DeCarli, Charles and Mosley, Thomas and Ang, Wei and van Beijsterveldt, Toos and Bergen, Nienke and Benke, Kelly and Berry, Diane and Coin, Lachlan and Elliott, Paul and Frayling, Tim and Gaillard, Romy and Groen-Blokhuis, Maria and Hadley, Dexter and Hottenga, Jouke Jan and Huikari, Ville and Hypponen, Elina and Kowgier, Matthew and Lawlor, Debbie A. and Lewin, Alex and Lindgren, Cecilia and Marsh, Julie and Middeldorp, Christel and Millwood, Iona and Nivard, Michel and Palmer, Lyle J. and Rodriguez, Alina and Sebert, Sylvain and Standl, Marie and Strachan, David P. and Uitterlinden, Andre G. and Valcárcel, Beatriz and White, Scott and Willemsen, Gonneke and Boomsma, Dorret I. and Grant, Struan F. A. and Hakonarson, Hakon and Hattersley, Andrew T. and Heinrich, Joachim and Jaddoe, Vincent W. V. and McCarthy, Mark I. and Pennell, Craig E. and Power, Chris and Widen, Elisabeth and Blakemore, Alexandra I. F. and Chiavacci, Rosetta M. and Feenstra, Bjarke and Fernandez-Banet, Julio and Hartikainen, Anna-Liisa and van der Heijden, Albert J. and Iñiguez, Carmen and Lathrop, Mark and McArdle, Wendy L. and Mølgaard, Anne and Newnham, John P. and Palotie, Aarno and Pouta, Annneli and Ring, Susan M. and Sovio, Ulla and Wichmann, H-Erich and Vissing, Nadja Hawwa and van Duijn, Cornelia M. and Koppelman, Gerard H. and Melbye, Mads and Bisgaard, Hans and Smith, George Davey and Adair, Linda S. and Atalay, Mustafa and Davis, Oliver S. P. and Flexeder, Claudia and Goh, Liang-Kee and Haworth, Claire M. A. and Hedebrand, Johannes and Hinney, Anke and Hirschhorn, Joel N. and Holloway, John W. and Holst, Claus and Horikoshi, Momoko and Kilpeläinen, Tuomas O. and Kirin, Mirna and Lakka, Hanna-Maaria and Lange, Leslie A. and Lehtimäki, Terho and Lindi, Virpi and Maggi, Reedik and Murray, Jeffrey C. and Nohr, Ellen Aagaard and Ntalla, Ioanna and Oken, Emily and Panoutsopoulou, Kalliope and Pararajasingham, Jennifer and Salem, Rany M. and Siitonen, Niina and Teo, Yik-Ying and Zeggini, Eleftheria and Cooper, Cyrus and Estivill, Xavier and Gillman, Matthew and Hocher, Berthold and Jarvelin, Marjo-Riitta and Lakka, Timo A. and Mohlke, Karen L. and Dedoussis, George V. and Ong, Ken K. and Pearson, Ewan R. and Price, Thomas S. and Raitakari, Olli T. and Saw, Seang-Mei and Scherag, Andre and Simell, Olli and Sørensen, Thorkild I. A. and Wilson, James F. (2012) Common variants at 12q15 and 12q24 are associated with infant head circumference. Nature Genetics, 44 (5). pp. 532-538. ISSN 1061-4036

Traylor, Matthew and Bevan, Stephen and Baron, Jean-Claude and Hassan, Ahamad and Lewis, Cathryn M. and Markus, Hugh S. (2015) Genetic architecture of lacunar stroke. Stroke; a journal of cerebral circulation, 46 (9). pp. 2407-2412. ISSN 0039-2499

Wang, Guoying and Ali Khan, Anokhi and Rodriguez, Alina and Sebert, Sylvain and Kaakinen, Marika and Cauchi, Stéphane and Froguel, Philippe and Hartikainen, Anna-Liisa and Pouta, Anneli and Järvelin, Marjo-Riitta (2012) The interplay of variants near LEKR and CCNL1 and social stress in relation to birth size. PLoS ONE, 7 (6). e38216. ISSN 1932-6203

Genome Wide Association Studies

Hamilton, Alexander and Gough, Stephen C. L. and Simmonds, Matthew J. (2013) Genetics of Graves’ disease. In: eLS - Encyclopedia of Life Sciences. Wiley. ISBN 9780470015902

Genome, Human

Todd, J. A. and Walker, N. M. and Cooper, J. D. and Smyth, D. J. and Downes, K. and Plagnol, V. and Bailey, R. and Nejentsev, S. and Field, S. F. and Payne, F. and Lowe, C. E. and Szeszko, J. S. and Hafler, J. P. and Zeitels, L. and Yang, J. H. M. and Vella, A. and Nutland, S. and Stevens, H. E. and Schuilenburg, H. and Coleman, G. and Maisuria, M. and Meadows, W. and Smink, L. J. and Healy, B. and Burren, O. S. and Lam, A. A. C. and Ovington, N. R. and Allen, J. and Adlem, E. and Leung, H-T. and Wallace, C. and Howson, J. M. M. and Guja, C. and Ionescu-Tırgoviste, C. and Genetics of T1D in Finland, . and Simmonds, M. J. and Heward, J. M. and Gough, S. C. L. and WTCCC, . and Dunger, D. B. and Wicker, L. S. and Clayton, D. G. (2007) Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nature Genetics, 39 (7). pp. 857-864. ISSN 1061-4036

Genome-Wide Association Study

Hafler, J. P. and Maier, L. M. and Cooper, J. D. and Plagnol, V. and Hinks, A. and Simmonds, M. J. and Stevens, H. and Walker, N. and Healy, B. and Howson, J. M. M. and Maisuria, M. and Duley, S. and Coleman, G. and Gough, S. C. L. and Worthington, J. and Kuchroo, V. K. and Wicker, L. S. and Todd, J. A. and IMSGC, . (2009) CD226 Gly307Ser association with multiple autoimmune diseases. Genes and Immunity, 10 (1). pp. 5-10. ISSN 1466-4879

Hunt, K. A. and Mistry, V. and Bockett, N. A. and Ahmad, T. and Ban, M. and Barker, J. N. and Barrett, J. C. and Blackburn, H. and Brand, O. J. and Burren, O. and Capon, F. and Compston, A. and Gough, S. C. L. and Jostins, L. and Kong, Y. and Lee, J. C. and Lek, M. and MacArthur, D. G. and Mansfield, J. C. and Mathew, C. G. and Mein, C. A. and Mirza, M. and Nutland, S. and Onengut-Gumuscu, S. and Papouli, E. and Parkes, M. and Rich, S. S. and Sawcer, S. and Satsangi, J. and Simmonds, M. J. and Trembath, R. C. and Walker, N. M. and Wozniak, E. and Todd, J. A. and Simpson, M. A. and Plagnol, V. and van Heel, D. A. (2013) Negligible impact of rare autoimmune-locus coding-region variants on missing heritability. Nature, 498 (7453). pp. 232-235. ISSN 0028-0836

Medici, M. and Porcu, E. and Pistis, G. and Teumer, A. and Brown, S. J. and Jensen, R. A. and Rawal, R. and Roef, G. L. and Plantinga, T. S. and Vermeulen, S. H. and Lahti, J. and Simmonds, M. J. and Husemoen, L. N. N. and Freathy, R. M. and Shields, B. M. and Pietzner, D. and Nagy, R. and Broer, L. and Chaker, L. and Korevaar, T. I. M. and Plia, M. G. and Sala, C. and Volker, U. and Richards, J. B. and Sweep, F. C. and Gieger, C. and Corre, T. and Kajantie, E. and Thuesen, B. and Taes, Y. E. and Visser, W. E. and Hattersley, A. T. and Kratzsch, J. and Hamilton, A. and Li, W. and Homuth, G. and Lobina, M. and Mariotti, S. and Soranzo, N. and Cocca, M. and Nauck, M. and Spielhagen, C. and Ross, A. and Arnold, A. and van de Bunt, M. and Liyanarachchi, S. and Heier, M. and Grabe, H. J. and Masciullo, C. and Galesloot, T. E. and Lim, E. M. and Reischl, E. and Leedman, P. J. and Lai, S. and Delitala, A. and Bremner, A. P. and Philips, D. I. W. and Beilby, J. P. and Mulas, A. and Vocale, M. and Abecasis, G. and Forsen, T. and James, A. and Widen, E. and Hui, J. and Prokisch, H. and Rietzschel, E. E. and Palotie, A. and Feddema, P. and Fletcher, S. J. and Schramm, K. and Rotter, J. I. and Kluttig, A. and Radke, D. and Traglia, M. and Surdulescu, G. L. and He, H. and Franklyn, J. A. and Tiller, D. and Vaidya, B. and de Meyer, T. and Jørgensen, T. and Eriksson, J. G. and O’Leary, P. C. and Wichmann, E. and Hermus, A. R. and Psaty, B. M. and Ittermann, T. and Hofman, A. and Bosi, E. and Schlessinger, D. and Wallaschofski, H. and Pirastu, N. and Aulchenko, Y.S. and de la Chapelle, A. and Netea-Maier, R.T. and Gough, S.C.L. and Meyer zu Schwabedissen, H. and Frayling, T.M. and Kaufman, J.M. and Linneberg, A. and Raikkonen, K. and Smit, J.W.A. and Kiemeney, L.A. and Rivadeneira, F. and Uitterlinden, A.G. and Walsh, J.P. and Meisinger, C. and den Heijer, M. and Visser, T.J. and Spector, T.D. and Wilson, S.G. and Volzke, H. and Cappola, A. and Toniolo, D. and Sanna, S. and Naitza, S. and Peeters, R.P. (2014) Identification of novel genetic loci associated with thyroid peroxidase antibodies and clinical thyroid disease. PLoS Genetics, 10 (2). ISSN 15537390

Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN 1553-7390

Simmonds, Matthew J. (2013) GWAS in autoimmune thyroid disease: redefining our understanding of pathogenesis. Nature Reviews Endocrinology, 9 (5). pp. 277-287. ISSN 1759-5029

Simmonds, Matthew J. and Gough, Stephen C. L. (2011) The search for the genetic contribution to autoimmune thyroid disease: The never ending story? Briefings in Functional Genomics, 10 (2). pp. 77-90. ISSN 2041-2649

Genome-wide association studies

Taal, H. Rob and St Pourcain, Beate and Thiering, Elisabeth and Das, Shikta and Mook-Kanamori, Dennis O. and Warrington, Nicole M. and Kaakinen, Marika and Kreiner-Møller, Eskil and Bradfield, Jonathan P. and Freathy, Rachel M. and Geller, Frank and Guxens, Mònica and Cousminer, Diana L. and Kerkhof, Marjan and Timpson, Nicholas J. and Ikram, M. Arfan and Beilin, Lawrence J. and Bønnelykke, Klaus and Buxton, Jessica L. and Charoen, Pimphen and Chawes, Bo Lund Krogsgaard and Eriksson, Johan and Evans, David M. and Hofman, Albert and Kemp, John P. and Kim, Cecilia E. and Klopp, Norman and Lahti, Jari and Lye, Stephen J. and McMahon, George and Mentch, Frank D. and Müller-Nurasyid, Martina and O'Reilly, Paul F. and Prokopenko, Inga and Rivadeneira, Fernando and Steegers, Eric A. P. and Sunyer, Jordi and Tiesler, Carla and Yaghootkar, Hanieh and Fornage, Myriam and Smith, Albert V. and Seshadri, Sudha and Schmidt, Reinhold and Debette, Stéphanie and Vrooman, Henri A. and Sigurdsson, Sigurdur and Ropele, Stefan and Coker, Laura H. and Longstreth, W. T. and Niessen, Wiro J. and DeStefano, Anita L. and Beiser, Alexa and Zijdenbos, Alex P. and Struchalin, Maksim and Jack, Clifford R. and Nalls, Mike A. and Au, Rhoda and Gudnason, Haukur and van der Lugt, Aad and Harris, Tamara B. and Meeks, William M. and Vernooij, Meike W. and van Buchem, Mark A. and Catellier, Diane and Gudnason, Vilmundur and Windham, B. Gwen and Wolf, Philip A. and van Duijn, Cornelia M. and Mosley, Thomas H. and Schmidt, Helena and Launer, Lenore J. and Breteler, Monique M. B. and DeCarli, Charles and Mosley, Thomas and Ang, Wei and van Beijsterveldt, Toos and Bergen, Nienke and Benke, Kelly and Berry, Diane and Coin, Lachlan and Elliott, Paul and Frayling, Tim and Gaillard, Romy and Groen-Blokhuis, Maria and Hadley, Dexter and Hottenga, Jouke Jan and Huikari, Ville and Hypponen, Elina and Kowgier, Matthew and Lawlor, Debbie A. and Lewin, Alex and Lindgren, Cecilia and Marsh, Julie and Middeldorp, Christel and Millwood, Iona and Nivard, Michel and Palmer, Lyle J. and Rodriguez, Alina and Sebert, Sylvain and Standl, Marie and Strachan, David P. and Uitterlinden, Andre G. and Valcárcel, Beatriz and White, Scott and Willemsen, Gonneke and Boomsma, Dorret I. and Grant, Struan F. A. and Hakonarson, Hakon and Hattersley, Andrew T. and Heinrich, Joachim and Jaddoe, Vincent W. V. and McCarthy, Mark I. and Pennell, Craig E. and Power, Chris and Widen, Elisabeth and Blakemore, Alexandra I. F. and Chiavacci, Rosetta M. and Feenstra, Bjarke and Fernandez-Banet, Julio and Hartikainen, Anna-Liisa and van der Heijden, Albert J. and Iñiguez, Carmen and Lathrop, Mark and McArdle, Wendy L. and Mølgaard, Anne and Newnham, John P. and Palotie, Aarno and Pouta, Annneli and Ring, Susan M. and Sovio, Ulla and Wichmann, H-Erich and Vissing, Nadja Hawwa and van Duijn, Cornelia M. and Koppelman, Gerard H. and Melbye, Mads and Bisgaard, Hans and Smith, George Davey and Adair, Linda S. and Atalay, Mustafa and Davis, Oliver S. P. and Flexeder, Claudia and Goh, Liang-Kee and Haworth, Claire M. A. and Hedebrand, Johannes and Hinney, Anke and Hirschhorn, Joel N. and Holloway, John W. and Holst, Claus and Horikoshi, Momoko and Kilpeläinen, Tuomas O. and Kirin, Mirna and Lakka, Hanna-Maaria and Lange, Leslie A. and Lehtimäki, Terho and Lindi, Virpi and Maggi, Reedik and Murray, Jeffrey C. and Nohr, Ellen Aagaard and Ntalla, Ioanna and Oken, Emily and Panoutsopoulou, Kalliope and Pararajasingham, Jennifer and Salem, Rany M. and Siitonen, Niina and Teo, Yik-Ying and Zeggini, Eleftheria and Cooper, Cyrus and Estivill, Xavier and Gillman, Matthew and Hocher, Berthold and Jarvelin, Marjo-Riitta and Lakka, Timo A. and Mohlke, Karen L. and Dedoussis, George V. and Ong, Ken K. and Pearson, Ewan R. and Price, Thomas S. and Raitakari, Olli T. and Saw, Seang-Mei and Scherag, Andre and Simell, Olli and Sørensen, Thorkild I. A. and Wilson, James F. (2012) Common variants at 12q15 and 12q24 are associated with infant head circumference. Nature Genetics, 44 (5). pp. 532-538. ISSN 1061-4036

Genomics

Langlois, Adele (2006) The governance of genomic information: will it come of age? Genomics, Society and Policy, 2 (3). pp. 49-63. ISSN UNSPECIFIED

Genotype

Simmonds, M. J. and Heward, J. M. and Barrett, J. C. and Franklyn, J. A. and Gough, S. C. L. (2006) Association of the BTNL2 rs2076530 single nucleotide polymorphism with Graves' disease appears to be secondary to DRB1 exon 2 position beta74. Clinical Endocrinology, 65 (4). pp. 429-432. ISSN 0300-0664

Simmonds, Matthew J. and Heward, J. M. and Carr-Smith, J. and Foxall, H. and Franklyn, J. A. and Gough, S. C. L. (2006) Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease. Journal of Clinical Endocrinology and Metabolism, 91 (3). pp. 1056-1061. ISSN 0021-972X

Zeitlin, A. A. and Heward, J. M. and Newby, P. R. and Carr-Smith, J. D. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2008) Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. Genes and Immunity, 9 (4). pp. 358-363. ISSN 1466-4879

Graves disease

Boelaert, Kristien and Newby, Paul R. and Simmonds, Matthew J. and Holder, Roger L. and Carr-Smith, Jacqueline D. and Heward, Joanne M. and Manji, Nilusha and Allahabadia, Amit and Armitage, Mary and Chatterjee, Krishna V. and Lazarus, John H. and Pearce, Simon H. and Vaidya, Bijay and Gough, Stephen C. and Franklyn, Jayne A. (2010) Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease. American Journal of Medicine, 123 (2). 183.e1-183.e9. ISSN 0002-9343

Brand, O. J. and Barrett, J. C. and Simmonds, M. J. and Newby, P. R. and McCabe, C. J. and Bruce, C. K. and Kysela, B. and Carr-Smith, J. D. and Brix, T. and Hunt, P. J. and Wiersinga, W. M. and Hegedus, L. and Connell, J. and Wass, J. A. H. and Franklyn, J. A. and Weetman, A. P. and Heward, J. M. and Gough, S. C. L. (2009) Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves' disease. Human Molecular Genetics, 18 (9). pp. 1704-1713. ISSN 0964-6906

Cooper, J. D. and Simmonds, M. J. and Walker, N.M. and Burren, O. and Brand, O.J. and Guo, H. and Wallace, C. and Stevens, H. and Coleman, G and Franklyn, J.A. and Todd, J.A. and Gough, S.C.L. (2012) Seven newly identified loci for autoimmune thyroid disease. Human Molecular Genetics, 21 (23). pp. 5202-5208. ISSN 0964-6906

Gough, S .C. L. and Simmonds, Matthew J. (2007) The HLA region and autoimmune disease: associations and mechanisms of action. Current Genomics, 8 (7). pp. 453-465. ISSN 1389-2029

Heward, J. M. and Simmonds, M. J. and Carr-Smith, J. and Foxall, H. and Franklyn, J. A. and Gough, S. C. L. (2004) A single nucleotide polymorphism in the CD40 gene on chromosome 20q (GD-2) provides no evidence for susceptibility to Graves' disease in UK Caucasians. Clinical Endocrinology, 61 (2). pp. 269-272. ISSN 0300-0664

Medici, M. and Porcu, E. and Pistis, G. and Teumer, A. and Brown, S. J. and Jensen, R. A. and Rawal, R. and Roef, G. L. and Plantinga, T. S. and Vermeulen, S. H. and Lahti, J. and Simmonds, M. J. and Husemoen, L. N. N. and Freathy, R. M. and Shields, B. M. and Pietzner, D. and Nagy, R. and Broer, L. and Chaker, L. and Korevaar, T. I. M. and Plia, M. G. and Sala, C. and Volker, U. and Richards, J. B. and Sweep, F. C. and Gieger, C. and Corre, T. and Kajantie, E. and Thuesen, B. and Taes, Y. E. and Visser, W. E. and Hattersley, A. T. and Kratzsch, J. and Hamilton, A. and Li, W. and Homuth, G. and Lobina, M. and Mariotti, S. and Soranzo, N. and Cocca, M. and Nauck, M. and Spielhagen, C. and Ross, A. and Arnold, A. and van de Bunt, M. and Liyanarachchi, S. and Heier, M. and Grabe, H. J. and Masciullo, C. and Galesloot, T. E. and Lim, E. M. and Reischl, E. and Leedman, P. J. and Lai, S. and Delitala, A. and Bremner, A. P. and Philips, D. I. W. and Beilby, J. P. and Mulas, A. and Vocale, M. and Abecasis, G. and Forsen, T. and James, A. and Widen, E. and Hui, J. and Prokisch, H. and Rietzschel, E. E. and Palotie, A. and Feddema, P. and Fletcher, S. J. and Schramm, K. and Rotter, J. I. and Kluttig, A. and Radke, D. and Traglia, M. and Surdulescu, G. L. and He, H. and Franklyn, J. A. and Tiller, D. and Vaidya, B. and de Meyer, T. and Jørgensen, T. and Eriksson, J. G. and O’Leary, P. C. and Wichmann, E. and Hermus, A. R. and Psaty, B. M. and Ittermann, T. and Hofman, A. and Bosi, E. and Schlessinger, D. and Wallaschofski, H. and Pirastu, N. and Aulchenko, Y.S. and de la Chapelle, A. and Netea-Maier, R.T. and Gough, S.C.L. and Meyer zu Schwabedissen, H. and Frayling, T.M. and Kaufman, J.M. and Linneberg, A. and Raikkonen, K. and Smit, J.W.A. and Kiemeney, L.A. and Rivadeneira, F. and Uitterlinden, A.G. and Walsh, J.P. and Meisinger, C. and den Heijer, M. and Visser, T.J. and Spector, T.D. and Wilson, S.G. and Volzke, H. and Cappola, A. and Toniolo, D. and Sanna, S. and Naitza, S. and Peeters, R.P. (2014) Identification of novel genetic loci associated with thyroid peroxidase antibodies and clinical thyroid disease. PLoS Genetics, 10 (2). ISSN 15537390

Newby, P. R. and Roberts-Davies, E. L. and Brand, O. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2007) Tag SNP screening of the PDCD1 gene for association with Graves' disease. Clinical Endocrinology, 67 (1). pp. 125-128. ISSN 0300-0664

Newby, Paul R. and Pickles, Oliver J. and Mazumdar, Samaresh and Brand, Oliver J. and Carr-Smith, Jacqueline D. and Pearce, Simon H. S. and Franklyn, Jayne A. and Evans, David M. and Simmonds, Matthew J. and Gough, Stephen C. L. and Welcome Trust Case-Control Consortium (WTCCC), . (2010) Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study. European Journal of Human Genetics, 18 (9). pp. 1021-1026. ISSN 1018-4813

Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN 1553-7390

Simmonds, M. J. and Gough, S. C. L. (2004) Unravelling the genetic complexity of autoimmune thyroid disease: HLA, CTLA-4 and beyond. Clinical and Experimental Immunology, 136 (1). pp. 1-10. ISSN 0009-9104

Simmonds, M. J. and Heward, J. M. and Barrett, J. C. and Franklyn, J. A. and Gough, S. C. L. (2006) Association of the BTNL2 rs2076530 single nucleotide polymorphism with Graves' disease appears to be secondary to DRB1 exon 2 position beta74. Clinical Endocrinology, 65 (4). pp. 429-432. ISSN 0300-0664

Simmonds, M. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. (2005) The CD40 Kozak SNP: a new susceptibility loci for Graves' disease? Clinical Endocrinology, 63 (2). pp. 232-233. ISSN 0300 0664

Simmonds, M. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. (2005) IL-13 and chromosome 5q31-q33: problems of identifying association within regions of linkage to Graves' disease. Clinical Endocrinology, 63 (6). pp. 695-697. ISSN 0300-0664

Simmonds, M. J. and Heward, J.M. and Howson, J.M.M. and Foxall, H. and Nithiyananthan, R. and Franklyn, J.A. and Gough, S.C.L. (2004) A systematic approach to the assesment of known TNF-alpha polymorphisms in Graves' disease. Genes and Immunity, 5 (4). pp. 267-273. ISSN 1466-4879

Simmonds, M. J. and Howson, J. M. M. and Heward, J. M. and Carr-Smith, J. and Franklyn, J. A. and Todd, J. A. and Gough, S. C. L. (2007) A novel and major association of HLA-C in Graves' disease that eclipses the classical HLA-DRB1 effect. Human Molecular Genetics, 16 (18). pp. 2149-2153. ISSN 0964-6906

Simmonds, Matthew J. (2013) GWAS in autoimmune thyroid disease: redefining our understanding of pathogenesis. Nature Reviews Endocrinology, 9 (5). pp. 277-287. ISSN 1759-5029

Simmonds, Matthew J. and Brand, Oliver J. and Barrett, Jeffrey C. and Newby, Paul R. and Franklyn, Jayne A. and Gough, Stephen C. L. (2010) Association of Fc receptor-like 5 (FCRL5) with Graves' disease is secondary to the effect of FCRL3. Clinical Endocrinology, 73 (5). pp. 654-660. ISSN 0300-0664

Simmonds, Matthew J. and Heward, J. M. and Carr-Smith, J. and Foxall, H. and Franklyn, J. A. and Gough, S. C. L. (2006) Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease. Journal of Clinical Endocrinology and Metabolism, 91 (3). pp. 1056-1061. ISSN 0021-972X

Simmonds, Matthew J. and Heward, Joanne M. and Kelly, M. Ann and Allahabadia, Amit and Foxall, Helen and Gordon, Caroline and Franklyn, Jayne A. and Gough, Stephen C. L. (2002) A nonsense mutation in exon 2 of the DNase I gene is not present in UK subjects with systemic lupus erythematosus and Graves' disease: Comment on the article by Rood et al. Arthritis and Rheumatism, 46 (11). pp. 3109-3110. ISSN 0004-3591

Simmonds, Matthew J. and Howson, Joanna M. M. and Heward, Joanne M. and Cordell, Heather J. and Foxall, Helen and Carr-Smith, Jackie and Gibson, Sarah M. and Walker, Neil and Tomer, Yaron and Franklyn, Jayne A. and Todd, John A. and Gough, Stephen C. L. (2005) Regression mapping of association between the human leukocyte antigen region and Graves' disease. American Journal of Human Genetics, 76 (1). pp. 157-163. ISSN 0002-9297

Yesmin, K. and Hargreaves, C. and Newby, P. R. and Brand, O. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2010) Association of FcGRIIa with Graves' disease: a potential role for dysregulated autoantibody clearance in disease onset/progression. Clinical Endocrinology, 73 (1). pp. 119-125. ISSN 0300-0664

Zeitlin, A. and Simmonds, M. J. and Gough, S. C. (2008) Genetic developments in autoimmune thyroid disease: an evolutionary process. Clinical Endocrinology, 68 (5). pp. 671-682. ISSN 0300-0664

Zeitlin, A. A. and Heward, J. M. and Brand, O. J. and Newby, P. R. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2006) Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. Clinical Endocrinology, 65 (3). pp. 380-384. ISSN 0300-0664

Zeitlin, A. A. and Heward, J. M. and Newby, P. R. and Carr-Smith, J. D. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2008) Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. Genes and Immunity, 9 (4). pp. 358-363. ISSN 1466-4879

Graves disease, Case-Control Studies

Simmonds, M. J. and Heward, J.M. and Howson, J.M.M. and Foxall, H. and Nithiyananthan, R. and Franklyn, J.A. and Gough, S.C.L. (2004) A systematic approach to the assesment of known TNF-alpha polymorphisms in Graves' disease. Genes and Immunity, 5 (4). pp. 267-273. ISSN 1466-4879

Graves’ disease

Hamilton, Alexander and Gough, Stephen C. L. and Simmonds, Matthew J. (2013) Genetics of Graves’ disease. In: eLS - Encyclopedia of Life Sciences. Wiley. ISBN 9780470015902

Great Britain

Boelaert, Kristien and Newby, Paul R. and Simmonds, Matthew J. and Holder, Roger L. and Carr-Smith, Jacqueline D. and Heward, Joanne M. and Manji, Nilusha and Allahabadia, Amit and Armitage, Mary and Chatterjee, Krishna V. and Lazarus, John H. and Pearce, Simon H. and Vaidya, Bijay and Gough, Stephen C. and Franklyn, Jayne A. (2010) Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease. American Journal of Medicine, 123 (2). 183.e1-183.e9. ISSN 0002-9343

Chand, S. and Holle, J. U. and Hilhorst, M. and Simmonds, M. J. and Smith, S. and Kamesh, L. and Hewins, P. and McKnight, A. J. and Maxwell, A. P. and Willem Cohen Tervaert, J. and Wieczorek, S. and Harper, L. and Borrows, R. (2013) Caveolin-1 single nucleotide polymorphism in antineutrophil cytoplasmic antibody associated vasculitis. PLoS ONE, 8 (7). ISSN 1932-6203

Heward, J. M. and Simmonds, M. J. and Carr-Smith, J. and Foxall, H. and Franklyn, J. A. and Gough, S. C. L. (2004) A single nucleotide polymorphism in the CD40 gene on chromosome 20q (GD-2) provides no evidence for susceptibility to Graves' disease in UK Caucasians. Clinical Endocrinology, 61 (2). pp. 269-272. ISSN 0300-0664

Hunt, K. A. and Mistry, V. and Bockett, N. A. and Ahmad, T. and Ban, M. and Barker, J. N. and Barrett, J. C. and Blackburn, H. and Brand, O. J. and Burren, O. and Capon, F. and Compston, A. and Gough, S. C. L. and Jostins, L. and Kong, Y. and Lee, J. C. and Lek, M. and MacArthur, D. G. and Mansfield, J. C. and Mathew, C. G. and Mein, C. A. and Mirza, M. and Nutland, S. and Onengut-Gumuscu, S. and Papouli, E. and Parkes, M. and Rich, S. S. and Sawcer, S. and Satsangi, J. and Simmonds, M. J. and Trembath, R. C. and Walker, N. M. and Wozniak, E. and Todd, J. A. and Simpson, M. A. and Plagnol, V. and van Heel, D. A. (2013) Negligible impact of rare autoimmune-locus coding-region variants on missing heritability. Nature, 498 (7453). pp. 232-235. ISSN 0028-0836

Moore, Jason and McKnight, Amy Jayne and Döhler, Bernd and Simmonds, Matthew J. and Courtney, Aisling E. and Brand, Oliver J. and Briggs, David and Ball, Simon and Cockwell, Paul and Patterson, Christopher C. and Maxwell, Alexander P. and Gough, Stephen C. L. and Opelz, Gerhard and Borrows, Richard (2012) Donor ABCB1 variant associates with increased risk for kidney allograft failure. Journal of the American Society of Nephrology, 23 (11). pp. 1891-1899. ISSN 1046-6673

Newby, Paul R. and Pickles, Oliver J. and Mazumdar, Samaresh and Brand, Oliver J. and Carr-Smith, Jacqueline D. and Pearce, Simon H. S. and Franklyn, Jayne A. and Evans, David M. and Simmonds, Matthew J. and Gough, Stephen C. L. and Welcome Trust Case-Control Consortium (WTCCC), . (2010) Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study. European Journal of Human Genetics, 18 (9). pp. 1021-1026. ISSN 1018-4813

Simmonds, Matthew J. and Heward, Joanne M. and Kelly, M. Ann and Allahabadia, Amit and Foxall, Helen and Gordon, Caroline and Franklyn, Jayne A. and Gough, Stephen C. L. (2002) A nonsense mutation in exon 2 of the DNase I gene is not present in UK subjects with systemic lupus erythematosus and Graves' disease: Comment on the article by Rood et al. Arthritis and Rheumatism, 46 (11). pp. 3109-3110. ISSN 0004-3591

Zeitlin, A. A. and Heward, J. M. and Newby, P. R. and Carr-Smith, J. D. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2008) Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. Genes and Immunity, 9 (4). pp. 358-363. ISSN 1466-4879

HDLBP gene

Newby, Paul R. and Pickles, Oliver J. and Mazumdar, Samaresh and Brand, Oliver J. and Carr-Smith, Jacqueline D. and Pearce, Simon H. S. and Franklyn, Jayne A. and Evans, David M. and Simmonds, Matthew J. and Gough, Stephen C. L. and Welcome Trust Case-Control Consortium (WTCCC), . (2010) Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study. European Journal of Human Genetics, 18 (9). pp. 1021-1026. ISSN 1018-4813

HLA Antigens

Simmonds, Matthew and Gough, S. C. L. (2005) Genetic insights into disease mechanisms of autoimmunity. British Medical Bulletin, 71 (1). pp. 93-113. ISSN 0007-1420

Zeitlin, A. and Simmonds, M. J. and Gough, S. C. (2008) Genetic developments in autoimmune thyroid disease: an evolutionary process. Clinical Endocrinology, 68 (5). pp. 671-682. ISSN 0300-0664

HLA B antigen

Gough, S .C. L. and Simmonds, Matthew J. (2007) The HLA region and autoimmune disease: associations and mechanisms of action. Current Genomics, 8 (7). pp. 453-465. ISSN 1389-2029

Simmonds, M. J. and Howson, J. M. M. and Heward, J. M. and Carr-Smith, J. and Franklyn, J. A. and Todd, J. A. and Gough, S. C. L. (2007) A novel and major association of HLA-C in Graves' disease that eclipses the classical HLA-DRB1 effect. Human Molecular Genetics, 16 (18). pp. 2149-2153. ISSN 0964-6906

HLA B27 antigen

Gough, S .C. L. and Simmonds, Matthew J. (2007) The HLA region and autoimmune disease: associations and mechanisms of action. Current Genomics, 8 (7). pp. 453-465. ISSN 1389-2029

HLA C antigen

Gough, S .C. L. and Simmonds, Matthew J. (2007) The HLA region and autoimmune disease: associations and mechanisms of action. Current Genomics, 8 (7). pp. 453-465. ISSN 1389-2029

Simmonds, M. J. and Howson, J. M. M. and Heward, J. M. and Carr-Smith, J. and Franklyn, J. A. and Todd, J. A. and Gough, S. C. L. (2007) A novel and major association of HLA-C in Graves' disease that eclipses the classical HLA-DRB1 effect. Human Molecular Genetics, 16 (18). pp. 2149-2153. ISSN 0964-6906

HLA DQA1 antigen

Gough, S .C. L. and Simmonds, Matthew J. (2007) The HLA region and autoimmune disease: associations and mechanisms of action. Current Genomics, 8 (7). pp. 453-465. ISSN 1389-2029

Simmonds, M. J. and Howson, J. M. M. and Heward, J. M. and Carr-Smith, J. and Franklyn, J. A. and Todd, J. A. and Gough, S. C. L. (2007) A novel and major association of HLA-C in Graves' disease that eclipses the classical HLA-DRB1 effect. Human Molecular Genetics, 16 (18). pp. 2149-2153. ISSN 0964-6906

Simmonds, Matthew J. and Howson, Joanna M. M. and Heward, Joanne M. and Cordell, Heather J. and Foxall, Helen and Carr-Smith, Jackie and Gibson, Sarah M. and Walker, Neil and Tomer, Yaron and Franklyn, Jayne A. and Todd, John A. and Gough, Stephen C. L. (2005) Regression mapping of association between the human leukocyte antigen region and Graves' disease. American Journal of Human Genetics, 76 (1). pp. 157-163. ISSN 0002-9297

Zeitlin, A. A. and Heward, J. M. and Newby, P. R. and Carr-Smith, J. D. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2008) Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. Genes and Immunity, 9 (4). pp. 358-363. ISSN 1466-4879

HLA DQB1 antigen

Gough, S .C. L. and Simmonds, Matthew J. (2007) The HLA region and autoimmune disease: associations and mechanisms of action. Current Genomics, 8 (7). pp. 453-465. ISSN 1389-2029

Simmonds, M. J. and Howson, J. M. M. and Heward, J. M. and Carr-Smith, J. and Franklyn, J. A. and Todd, J. A. and Gough, S. C. L. (2007) A novel and major association of HLA-C in Graves' disease that eclipses the classical HLA-DRB1 effect. Human Molecular Genetics, 16 (18). pp. 2149-2153. ISSN 0964-6906

Simmonds, Matthew J. and Howson, Joanna M. M. and Heward, Joanne M. and Cordell, Heather J. and Foxall, Helen and Carr-Smith, Jackie and Gibson, Sarah M. and Walker, Neil and Tomer, Yaron and Franklyn, Jayne A. and Todd, John A. and Gough, Stephen C. L. (2005) Regression mapping of association between the human leukocyte antigen region and Graves' disease. American Journal of Human Genetics, 76 (1). pp. 157-163. ISSN 0002-9297

Zeitlin, A. A. and Heward, J. M. and Newby, P. R. and Carr-Smith, J. D. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2008) Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. Genes and Immunity, 9 (4). pp. 358-363. ISSN 1466-4879

HLA DR antigen

Gough, S .C. L. and Simmonds, Matthew J. (2007) The HLA region and autoimmune disease: associations and mechanisms of action. Current Genomics, 8 (7). pp. 453-465. ISSN 1389-2029

Simmonds, M. J. and Heward, J.M. and Howson, J.M.M. and Foxall, H. and Nithiyananthan, R. and Franklyn, J.A. and Gough, S.C.L. (2004) A systematic approach to the assesment of known TNF-alpha polymorphisms in Graves' disease. Genes and Immunity, 5 (4). pp. 267-273. ISSN 1466-4879

Simmonds, M. J. and Howson, J. M. M. and Heward, J. M. and Carr-Smith, J. and Franklyn, J. A. and Todd, J. A. and Gough, S. C. L. (2007) A novel and major association of HLA-C in Graves' disease that eclipses the classical HLA-DRB1 effect. Human Molecular Genetics, 16 (18). pp. 2149-2153. ISSN 0964-6906

Zeitlin, A. A. and Heward, J. M. and Newby, P. R. and Carr-Smith, J. D. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2008) Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. Genes and Immunity, 9 (4). pp. 358-363. ISSN 1466-4879

HLA DR antigen, amino acid sequence

Simmonds, Matthew J. and Howson, Joanna M. M. and Heward, Joanne M. and Cordell, Heather J. and Foxall, Helen and Carr-Smith, Jackie and Gibson, Sarah M. and Walker, Neil and Tomer, Yaron and Franklyn, Jayne A. and Todd, John A. and Gough, Stephen C. L. (2005) Regression mapping of association between the human leukocyte antigen region and Graves' disease. American Journal of Human Genetics, 76 (1). pp. 157-163. ISSN 0002-9297

HLA DR13 antigen

Zeitlin, A. A. and Heward, J. M. and Newby, P. R. and Carr-Smith, J. D. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2008) Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. Genes and Immunity, 9 (4). pp. 358-363. ISSN 1466-4879

HLA DR15 antigen

Zeitlin, A. A. and Heward, J. M. and Newby, P. R. and Carr-Smith, J. D. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2008) Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. Genes and Immunity, 9 (4). pp. 358-363. ISSN 1466-4879

HLA DR3 antigen

Zeitlin, A. A. and Heward, J. M. and Newby, P. R. and Carr-Smith, J. D. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2008) Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. Genes and Immunity, 9 (4). pp. 358-363. ISSN 1466-4879

HLA DR4 antigen

Zeitlin, A. A. and Heward, J. M. and Newby, P. R. and Carr-Smith, J. D. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2008) Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. Genes and Immunity, 9 (4). pp. 358-363. ISSN 1466-4879

HLA DR7 antigen

Zeitlin, A. A. and Heward, J. M. and Newby, P. R. and Carr-Smith, J. D. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2008) Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. Genes and Immunity, 9 (4). pp. 358-363. ISSN 1466-4879

HLA antigen

Gough, S .C. L. and Simmonds, Matthew J. (2007) The HLA region and autoimmune disease: associations and mechanisms of action. Current Genomics, 8 (7). pp. 453-465. ISSN 1389-2029

Simmonds, M. J. and Gough, S. C. L. (2004) Unravelling the genetic complexity of autoimmune thyroid disease: HLA, CTLA-4 and beyond. Clinical and Experimental Immunology, 136 (1). pp. 1-10. ISSN 0009-9104

Simmonds, Matthew and Gough, S. C. L. (2005) Genetic insights into disease mechanisms of autoimmunity. British Medical Bulletin, 71 (1). pp. 93-113. ISSN 0007-1420

Zeitlin, A. and Simmonds, M. J. and Gough, S. C. (2008) Genetic developments in autoimmune thyroid disease: an evolutionary process. Clinical Endocrinology, 68 (5). pp. 671-682. ISSN 0300-0664

Zeitlin, A. A. and Heward, J. M. and Newby, P. R. and Carr-Smith, J. D. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2008) Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. Genes and Immunity, 9 (4). pp. 358-363. ISSN 1466-4879

HLA antigen class 1

Gough, S .C. L. and Simmonds, Matthew J. (2007) The HLA region and autoimmune disease: associations and mechanisms of action. Current Genomics, 8 (7). pp. 453-465. ISSN 1389-2029

HLA antigen class 2

Gough, S .C. L. and Simmonds, Matthew J. (2007) The HLA region and autoimmune disease: associations and mechanisms of action. Current Genomics, 8 (7). pp. 453-465. ISSN 1389-2029

Simmonds, Matthew J. and Howson, Joanna M. M. and Heward, Joanne M. and Cordell, Heather J. and Foxall, Helen and Carr-Smith, Jackie and Gibson, Sarah M. and Walker, Neil and Tomer, Yaron and Franklyn, Jayne A. and Todd, John A. and Gough, Stephen C. L. (2005) Regression mapping of association between the human leukocyte antigen region and Graves' disease. American Journal of Human Genetics, 76 (1). pp. 157-163. ISSN 0002-9297

Zeitlin, A. A. and Heward, J. M. and Newby, P. R. and Carr-Smith, J. D. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2008) Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. Genes and Immunity, 9 (4). pp. 358-363. ISSN 1466-4879

HLA antigen class 3

Gough, S .C. L. and Simmonds, Matthew J. (2007) The HLA region and autoimmune disease: associations and mechanisms of action. Current Genomics, 8 (7). pp. 453-465. ISSN 1389-2029

HLA matching

Simmonds, Matthew J. and Benavente, David and Brand, Oliver J. and Moore, Jason and Ball, Simon and Ferro, Charles J. and Briggs, David and Gough, Stephen C. L. and Borrows, Richard J. (2013) Skewing of female X-chromosome inactivation: an epigenetic risk factor for kidney transplantation outcome. Transplantation, 95 (5). e25-e28. ISSN 0041-1337

HLA system

Gough, S .C. L. and Simmonds, Matthew J. (2007) The HLA region and autoimmune disease: associations and mechanisms of action. Current Genomics, 8 (7). pp. 453-465. ISSN 1389-2029

Simmonds, M. J. and Gough, S. C. L. (2004) Unravelling the genetic complexity of autoimmune thyroid disease: HLA, CTLA-4 and beyond. Clinical and Experimental Immunology, 136 (1). pp. 1-10. ISSN 0009-9104

HLA-B Antigens

Simmonds, M. J. and Howson, J. M. M. and Heward, J. M. and Carr-Smith, J. and Franklyn, J. A. and Todd, J. A. and Gough, S. C. L. (2007) A novel and major association of HLA-C in Graves' disease that eclipses the classical HLA-DRB1 effect. Human Molecular Genetics, 16 (18). pp. 2149-2153. ISSN 0964-6906

HLA-C Antigens

Simmonds, M. J. and Howson, J. M. M. and Heward, J. M. and Carr-Smith, J. and Franklyn, J. A. and Todd, J. A. and Gough, S. C. L. (2007) A novel and major association of HLA-C in Graves' disease that eclipses the classical HLA-DRB1 effect. Human Molecular Genetics, 16 (18). pp. 2149-2153. ISSN 0964-6906

HLA-DQ Antigens

Simmonds, Matthew J. and Howson, Joanna M. M. and Heward, Joanne M. and Cordell, Heather J. and Foxall, Helen and Carr-Smith, Jackie and Gibson, Sarah M. and Walker, Neil and Tomer, Yaron and Franklyn, Jayne A. and Todd, John A. and Gough, Stephen C. L. (2005) Regression mapping of association between the human leukocyte antigen region and Graves' disease. American Journal of Human Genetics, 76 (1). pp. 157-163. ISSN 0002-9297

Zeitlin, A. A. and Heward, J. M. and Newby, P. R. and Carr-Smith, J. D. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2008) Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. Genes and Immunity, 9 (4). pp. 358-363. ISSN 1466-4879

HLA-DR Antigens

Simmonds, M. J. and Heward, J. M. and Barrett, J. C. and Franklyn, J. A. and Gough, S. C. L. (2006) Association of the BTNL2 rs2076530 single nucleotide polymorphism with Graves' disease appears to be secondary to DRB1 exon 2 position beta74. Clinical Endocrinology, 65 (4). pp. 429-432. ISSN 0300-0664

Simmonds, M. J. and Howson, J. M. M. and Heward, J. M. and Carr-Smith, J. and Franklyn, J. A. and Todd, J. A. and Gough, S. C. L. (2007) A novel and major association of HLA-C in Graves' disease that eclipses the classical HLA-DRB1 effect. Human Molecular Genetics, 16 (18). pp. 2149-2153. ISSN 0964-6906

Simmonds, Matthew J. and Howson, Joanna M. M. and Heward, Joanne M. and Cordell, Heather J. and Foxall, Helen and Carr-Smith, Jackie and Gibson, Sarah M. and Walker, Neil and Tomer, Yaron and Franklyn, Jayne A. and Todd, John A. and Gough, Stephen C. L. (2005) Regression mapping of association between the human leukocyte antigen region and Graves' disease. American Journal of Human Genetics, 76 (1). pp. 157-163. ISSN 0002-9297

Zeitlin, A. A. and Heward, J. M. and Newby, P. R. and Carr-Smith, J. D. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2008) Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. Genes and Immunity, 9 (4). pp. 358-363. ISSN 1466-4879

Haplotypes

Brand, O. J. and Barrett, J. C. and Simmonds, M. J. and Newby, P. R. and McCabe, C. J. and Bruce, C. K. and Kysela, B. and Carr-Smith, J. D. and Brix, T. and Hunt, P. J. and Wiersinga, W. M. and Hegedus, L. and Connell, J. and Wass, J. A. H. and Franklyn, J. A. and Weetman, A. P. and Heward, J. M. and Gough, S. C. L. (2009) Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves' disease. Human Molecular Genetics, 18 (9). pp. 1704-1713. ISSN 0964-6906

Zeitlin, A. A. and Heward, J. M. and Brand, O. J. and Newby, P. R. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2006) Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. Clinical Endocrinology, 65 (3). pp. 380-384. ISSN 0300-0664

Zeitlin, A. A. and Heward, J. M. and Newby, P. R. and Carr-Smith, J. D. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2008) Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. Genes and Immunity, 9 (4). pp. 358-363. ISSN 1466-4879

Hashimoto Disease

Simmonds, Matthew J. (2013) GWAS in autoimmune thyroid disease: redefining our understanding of pathogenesis. Nature Reviews Endocrinology, 9 (5). pp. 277-287. ISSN 1759-5029

Hashimoto disease

Boelaert, Kristien and Newby, Paul R. and Simmonds, Matthew J. and Holder, Roger L. and Carr-Smith, Jacqueline D. and Heward, Joanne M. and Manji, Nilusha and Allahabadia, Amit and Armitage, Mary and Chatterjee, Krishna V. and Lazarus, John H. and Pearce, Simon H. and Vaidya, Bijay and Gough, Stephen C. and Franklyn, Jayne A. (2010) Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease. American Journal of Medicine, 123 (2). 183.e1-183.e9. ISSN 0002-9343

Cooper, J. D. and Simmonds, M. J. and Walker, N.M. and Burren, O. and Brand, O.J. and Guo, H. and Wallace, C. and Stevens, H. and Coleman, G and Franklyn, J.A. and Todd, J.A. and Gough, S.C.L. (2012) Seven newly identified loci for autoimmune thyroid disease. Human Molecular Genetics, 21 (23). pp. 5202-5208. ISSN 0964-6906

Gough, S .C. L. and Simmonds, Matthew J. (2007) The HLA region and autoimmune disease: associations and mechanisms of action. Current Genomics, 8 (7). pp. 453-465. ISSN 1389-2029

Medici, M. and Porcu, E. and Pistis, G. and Teumer, A. and Brown, S. J. and Jensen, R. A. and Rawal, R. and Roef, G. L. and Plantinga, T. S. and Vermeulen, S. H. and Lahti, J. and Simmonds, M. J. and Husemoen, L. N. N. and Freathy, R. M. and Shields, B. M. and Pietzner, D. and Nagy, R. and Broer, L. and Chaker, L. and Korevaar, T. I. M. and Plia, M. G. and Sala, C. and Volker, U. and Richards, J. B. and Sweep, F. C. and Gieger, C. and Corre, T. and Kajantie, E. and Thuesen, B. and Taes, Y. E. and Visser, W. E. and Hattersley, A. T. and Kratzsch, J. and Hamilton, A. and Li, W. and Homuth, G. and Lobina, M. and Mariotti, S. and Soranzo, N. and Cocca, M. and Nauck, M. and Spielhagen, C. and Ross, A. and Arnold, A. and van de Bunt, M. and Liyanarachchi, S. and Heier, M. and Grabe, H. J. and Masciullo, C. and Galesloot, T. E. and Lim, E. M. and Reischl, E. and Leedman, P. J. and Lai, S. and Delitala, A. and Bremner, A. P. and Philips, D. I. W. and Beilby, J. P. and Mulas, A. and Vocale, M. and Abecasis, G. and Forsen, T. and James, A. and Widen, E. and Hui, J. and Prokisch, H. and Rietzschel, E. E. and Palotie, A. and Feddema, P. and Fletcher, S. J. and Schramm, K. and Rotter, J. I. and Kluttig, A. and Radke, D. and Traglia, M. and Surdulescu, G. L. and He, H. and Franklyn, J. A. and Tiller, D. and Vaidya, B. and de Meyer, T. and Jørgensen, T. and Eriksson, J. G. and O’Leary, P. C. and Wichmann, E. and Hermus, A. R. and Psaty, B. M. and Ittermann, T. and Hofman, A. and Bosi, E. and Schlessinger, D. and Wallaschofski, H. and Pirastu, N. and Aulchenko, Y.S. and de la Chapelle, A. and Netea-Maier, R.T. and Gough, S.C.L. and Meyer zu Schwabedissen, H. and Frayling, T.M. and Kaufman, J.M. and Linneberg, A. and Raikkonen, K. and Smit, J.W.A. and Kiemeney, L.A. and Rivadeneira, F. and Uitterlinden, A.G. and Walsh, J.P. and Meisinger, C. and den Heijer, M. and Visser, T.J. and Spector, T.D. and Wilson, S.G. and Volzke, H. and Cappola, A. and Toniolo, D. and Sanna, S. and Naitza, S. and Peeters, R.P. (2014) Identification of novel genetic loci associated with thyroid peroxidase antibodies and clinical thyroid disease. PLoS Genetics, 10 (2). ISSN 15537390

Simmonds, M. J. and Gough, S. C. L. (2004) Unravelling the genetic complexity of autoimmune thyroid disease: HLA, CTLA-4 and beyond. Clinical and Experimental Immunology, 136 (1). pp. 1-10. ISSN 0009-9104

Zeitlin, A. A. and Heward, J. M. and Newby, P. R. and Carr-Smith, J. D. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2008) Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. Genes and Immunity, 9 (4). pp. 358-363. ISSN 1466-4879

Histocompatibility Antigens Class I

Simmonds, Matthew and Gough, S. C. L. (2005) Genetic insights into disease mechanisms of autoimmunity. British Medical Bulletin, 71 (1). pp. 93-113. ISSN 0007-1420

Histocompatibility Antigens Class II

Simmonds, Matthew and Gough, S. C. L. (2005) Genetic insights into disease mechanisms of autoimmunity. British Medical Bulletin, 71 (1). pp. 93-113. ISSN 0007-1420

Simmonds, Matthew J. and Howson, Joanna M. M. and Heward, Joanne M. and Cordell, Heather J. and Foxall, Helen and Carr-Smith, Jackie and Gibson, Sarah M. and Walker, Neil and Tomer, Yaron and Franklyn, Jayne A. and Todd, John A. and Gough, Stephen C. L. (2005) Regression mapping of association between the human leukocyte antigen region and Graves' disease. American Journal of Human Genetics, 76 (1). pp. 157-163. ISSN 0002-9297

Holliday junctions

Xing, Meichun and Wang, Xiaohui and Palmai-Pallag, Timea and Shen, Huahao and Helleday, Thomas and Hickson, Ian D. and Ying, Songmin (2015) Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response. Oncotarget, 6 (35). pp. 37638-37646. ISSN 1949-2553

Human Leukocyte Antigen

Hamilton, Alexander and Gough, Stephen C. L. and Simmonds, Matthew J. (2013) Genetics of Graves’ disease. In: eLS - Encyclopedia of Life Sciences. Wiley. ISBN 9780470015902

Human genetics

Forouzanfar, Mohammad H. and Alexander, Lily and Anderson, H. Ross and Bachman, Victoria F. and Biryukov, Stan and Brauer, Michael and Burnett, Richard and Casey, Daniel and Coates, Matthew M. and Cohen, Aaron and Delwiche, Kristen and Estep, Kara and Frostad, Joseph J. and KC, Astha and Kyu, Hmwe H. and Moradi-Lakeh, Maziar and Ng, Marie and Slepak, Erica Leigh and Thomas, Bernadette A. and Wagner, Joseph and Aasvang, Gunn Marit and Abbafati, Cristiana and Ozgoren, Ayse Abbasoglu and Abd-Allah, Foad and Abera, Semaw F. and Aboyans, Victor and Abraham, Biju and Abraham, Jerry Puthenpurakal and Abubakar, Ibrahim and Abu-Rmeileh, Niveen M. E. and Aburto, Tania C. and Achoki, Tom and Adelekan, Ademola and Adofo, Koranteng and Adou, Arsène K. and Adsuar, José C. and Afshin, Ashkan and Agardh, Emilie E. and Al Khabouri, Mazin J. and Al Lami, Faris H. and Alam, Sayed Saidul and Alasfoor, Deena and Albittar, Mohammed I. and Alegretti, Miguel A. and Aleman, Alicia V. and Alemu, Zewdie A. and Alfonso-Cristancho, Rafael and Alhabib, Samia and Ali, Raghib and Ali, Mohammed K. and Alla, François and Allebeck, Peter and Allen, Peter J. and Alsharif, Ubai and Alvarez, Elena and Alvis-Guzman, Nelson and Amankwaa, Adansi A. and Amare, Azmeraw T. and Ameh, Emmanuel A. and Ameli, Omid and Amini, Heresh and Ammar, Walid and Anderson, Benjamin O. and Antonio, Carl Abelardo T. and Anwari, Palwasha and Cunningham, Solveig Argeseanu and Arnlöv, Johan and Arsenijevic, Valentina S. Arsic and Artaman, Al and Asghar, Rana J. and Assadi, Reza and Atkins, Lydia S. and Atkinson, Charles and Avila, Marco A. and Awuah, Baffour and Badawi, Alaa and Bahit, Maria C. and Bakfalouni, Talal and Balakrishnan, Kalpana and Balalla, Shivanthi and Balu, Ravi Kumar and Banerjee, Amitava and Barber, Ryan M. and Barker-Collo, Suzanne L. and Barquera, Simon and Barregard, Lars and Barrero, Lope H. and Barrientos-Gutierrez, Tonatiuh and Basto-Abreu, Ana C. and Basu, Arindam and Basu, Sanjay and Basulaiman, Mohammed O. and Ruvalcaba, Carolina Batis and Beardsley, Justin and Bedi, Neeraj and Bekele, Tolesa and Bell, Michelle L. and Benjet, Corina and Bennett, Derrick A. and Benzian, Habib and Bernabé, Eduardo and Beyene, Tariku J. and Bhala, Neeraj and Bhalla, Ashish and Bhutta, Zulfiqar A. and Bikbov, Boris and Abdulhak, Aref A. Bin and Blore, Jed D. and Blyth, Fiona M. and Bohensky, Megan A. and Başara, Berrak Bora and Borges, Guilherme and Bornstein, Natan M. and Bose, Dipan and Boufous, Soufiane and Bourne, Rupert R. and Brainin, Michael and Brazinova, Alexandra and Breitborde, Nicholas J. and Brenner, Hermann and Briggs, Adam D. M. and Broday, David M. and Brooks, Peter M. and Bruce, Nigel G. and Brugha, Traolach S. and Brunekreef, Bert and Buchbinder, Rachelle and Bui, Linh N. and Bukhman, Gene and Bulloch, Andrew G. and Burch, Michael and Burney, Peter G. J. and Campos-Nonato, Ismael R. and Campuzano, Julio C. and Cantoral, Alejandra J. and Caravanos, Jack and Cárdenas, Rosario and Cardis, Elisabeth and Carpenter, David O. and Caso, Valeria and Castañeda-Orjuela, Carlos A. and Castro, Ruben E. and Catalá-López, Ferrán and Cavalleri, Fiorella and Çavlin, Alanur and Chadha, Vineet K. and Chang, Jung-chen and Charlson, Fiona J. and Chen, Honglei and Chen, Wanqing and Chen, Zhengming and Chiang, Peggy P. and Chimed-Ochir, Odgerel and Chowdhury, Rajiv and Christophi, Costas A. and Chuang, Ting-Wu and Chugh, Sumeet S. and Cirillo, Massimo and Claßen, Thomas K. D. and Colistro, Valentina and Colomar, Mercedes and Colquhoun, Samantha M. and Contreras, Alejandra G. and Cooper, Cyrus and Cooperrider, Kimberly and Cooper, Leslie T. and Coresh, Josef and Courville, Karen J. and Criqui, Michael H. and Cuevas-Nasu, Lucia and Damsere-Derry, James and Danawi, Hadi and Dandona, Lalit and Dandona, Rakhi and Dargan, Paul I. and Davis, Adrian and Davitoiu, Dragos V. and Dayama, Anand and de Castro, E. Filipa and De la Cruz-Góngora, Vanessa and De Leo, Diego and de Lima, Graça and Degenhardt, Louisa and del Pozo-Cruz, Borja and Dellavalle, Robert P. and Deribe, Kebede and Derrett, Sarah and Jarlais, Don C. Des and Dessalegn, Muluken and deVeber, Gabrielle A. and Devries, Karen M. and Dharmaratne, Samath D. and Dherani, Mukesh K. and Dicker, Daniel and Ding, Eric L and Dokova, Klara and Dorsey, E. Ray and Driscoll, Tim R. and Duan, Leilei and Durrani, Adnan M. and Ebel, Beth E. and Ellenbogen, Richard G. and Elshrek, Yousef M. and Endres, Matthias and Ermakov, Sergey P. and Erskine, Holly E. and Eshrati, Babak and Esteghamati, Alireza and Fahimi, Saman and Faraon, Emerito Jose A. and Farzadfar, Farshad and Fay, Derek F. J. and Feigin, Valery L. and Feigl, Andrea B. and Fereshtehnejad, Seyed-Mohammad and Ferrari, Alize J. and Ferri, Cleusa P. and Flaxman, Abraham D. and Fleming, Thomas D. and Foigt, Nataliya and Foreman, Kyle J. and Paleo, Urbano Fra and Franklin, Richard C. and Gabbe, Belinda and Gaffikin, Lynne and Gakidou, Emmanuela and Gamkrelidze, Amiran and Gankpé, Fortuné G. and Gansevoort, Ron T. and García-Guerra, Francisco A. and Gasana, Evariste and Geleijnse, Johanna M. and Gessner, Bradford D. and Gething, Pete and Gibney, Katherine B. and Gillum, Richard F. and Ginawi, Ibrahim A. M. and Giroud, Maurice and Giussani, Giorgia and Goenka, Shifalika and Goginashvili, Ketevan and Dantes, Hector Gomez and Gona, Philimon and de Cosio, Teresita Gonzalez and González-Castell, Dinorah and Gotay, Carolyn C. and Goto, Atsushi and Gouda, Hebe N. and Guerrant, Richard L. and Gugnani, Harish C. and Guillemin, Francis and Gunnell, David and Gupta, Rahul and Gupta, Rajeev and Gutiérrez, Reyna A. and Hafezi-Nejad, Nima and Hagan, Holly and Hagstromer, Maria and Halasa, Yara A. and Hamadeh, Randah R. and Hammami, Mouhanad and Hankey, Graeme J. and Hao, Yuantao and Harb, Hilda L. and Haregu, Tilahun Nigatu and Haro, Josep Maria and Havmoeller, Rasmus and Hay, Simon I. and Hedayati, Mohammad T. and Heredia-Pi, Ileana B. and Hernandez, Lucia and Heuton, Kyle R. and Heydarpour, Pouria and Hijar, Martha and Hoek, Hans W. and Hoffman, Howard J. and Hornberger, John C. and Hosgood, H. Dean and Hoy, Damian G. and Hsairi, Mohamed and Hu, Guoqing and Hu, Howard and Huang, Cheng and Huang, John J. and Hubbell, Bryan J. and Huiart, Laetitia and Husseini, Abdullatif and Iannarone, Marissa L. and Iburg, Kim M. and Idrisov, Bulat T. and Ikeda, Nayu and Innos, Kaire and Inoue, Manami and Islami, Farhad and Ismayilova, Samaya and Jacobsen, Kathryn H. and Jansen, Henrica A. and Jarvis, Deborah L. and Jassal, Simerjot K. and Jauregui, Alejandra and Jayaraman, Sudha and Jeemon, Panniyammakal and Jensen, Paul N. and Jha, Vivekanand and Jiang, Fan and Jiang, Guohong and Jiang, Ying and Jonas, Jost B. and Juel, Knud and Kan, Haidong and Roseline, Sidibe S Kany and Karam, Nadim E. and Karch, André and Karema, Corine K. and Karthikeyan, Ganesan and Kaul, Anil and Kawakami, Norito and Kazi, Dhruv S. and Kemp, Andrew H. and Kengne, Andre P. and Keren, Andre and Khader, Yousef S. and Khalifa, Shams Eldin Ali Hassan and Khan, Ejaz A. and Khang, Young-Ho and Khatibzadeh, Shahab and Khonelidze, Irma and Kieling, Christian and Kim, Daniel and Kim, Sungroul and Kim, Yunjin and Kimokoti, Ruth W and Kinfu, Yohannes and Kinge, Jonas M. and Kissela, Brett M. and Kivipelto, Miia and Knibbs, Luke D. and Knudsen, Ann Kristin and Kokubo, Yoshihiro and Kose, M. 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Humans

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Brand, O. J. and Barrett, J. C. and Simmonds, M. J. and Newby, P. R. and McCabe, C. J. and Bruce, C. K. and Kysela, B. and Carr-Smith, J. D. and Brix, T. and Hunt, P. J. and Wiersinga, W. M. and Hegedus, L. and Connell, J. and Wass, J. A. H. and Franklyn, J. A. and Weetman, A. P. and Heward, J. M. and Gough, S. C. L. (2009) Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves' disease. Human Molecular Genetics, 18 (9). pp. 1704-1713. ISSN 0964-6906

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Hafler, J. P. and Maier, L. M. and Cooper, J. D. and Plagnol, V. and Hinks, A. and Simmonds, M. J. and Stevens, H. and Walker, N. and Healy, B. and Howson, J. M. M. and Maisuria, M. and Duley, S. and Coleman, G. and Gough, S. C. L. and Worthington, J. and Kuchroo, V. K. and Wicker, L. S. and Todd, J. A. and IMSGC, . (2009) CD226 Gly307Ser association with multiple autoimmune diseases. Genes and Immunity, 10 (1). pp. 5-10. ISSN 1466-4879

Heward, J. M. and Simmonds, M. J. and Carr-Smith, J. and Foxall, H. and Franklyn, J. A. and Gough, S. C. L. (2004) A single nucleotide polymorphism in the CD40 gene on chromosome 20q (GD-2) provides no evidence for susceptibility to Graves' disease in UK Caucasians. Clinical Endocrinology, 61 (2). pp. 269-272. ISSN 0300-0664

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Hunt, K. A. and Smyth, D. J. and Balschun, T. and Ban, M. and Mistry, V. and Ahmed, T. and Barrett, J. C. and Bhaw-Rosun, L. and Bockett, N. A. and Brand, O. J. and Brouwer, E. and Concannon, P. and Cooper, J. D. and Dias, K-R. M. and van Diemen, C. C. and Dubois, P.C. and Edkins, S. and Fölster-Holst, R. and Fransen, K. and Glass, D. N. and Heap, G. A. R. and Hofmann, S. and Huizinga, T. W. J. and Hunt, S. and Langford, C. and Lee, J. and Mansfield, J. and Giovanna Marrosu, M. and Mathew, C. G. and Mein, C.A. and Müller-Quernheim, J. and Nutland, S. and Onengut-Gumuscu, S. and Ouwehand, W. and Pearce, K. and Prescott, N. and Posthumus, M. D. and Potter, S. and Rosati, G. and Sambrook, J. and Satsangi, J. and Schreiber, S. and Shtir, C. and Simmonds, M. J. and Sudman, M. and Thompson, S. D. and Toes, R. and Trynka, G. and Vyse, T. J. and Walker, N. M. and Weidinger, S. and Zhernakova, A. and Zoledziewska, M. and Weersma, R.K. and Gough, S.C.L. and Sawcer, S. and Wijmenga, C. and Parkes, M. and Cucca, F. and Franke, A. and Deloukas, P. and Rich, S. S. and Todd, J. A. and van Heel, D. A. (2011) Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry. Nature Genetics, 44 (1). pp. 3-5. ISSN 10614036

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Moore, J. and McKnight, A.J. and Simmonds, M. J. and Courtney, A. E. and Hanvesakul, R. and Brand, O. J. and Briggs, D. and Ball, S. and Cockwell, P. and Patterson, C.C. and Maxwell, A. P. and Gough, S. C. L. and Borrows, R. (2010) Association of caveolin-1 gene polymorphism with kidney transplant fibrosis and allograft failure. JAMA - Journal of the American Medical Association, 303 (13). pp. 1282-1287. ISSN 0098-7484

Moore, Jason and McKnight, Amy Jayne and Döhler, Bernd and Simmonds, Matthew J. and Courtney, Aisling E. and Brand, Oliver J. and Briggs, David and Ball, Simon and Cockwell, Paul and Patterson, Christopher C. and Maxwell, Alexander P. and Gough, Stephen C. L. and Opelz, Gerhard and Borrows, Richard (2012) Donor ABCB1 variant associates with increased risk for kidney allograft failure. Journal of the American Society of Nephrology, 23 (11). pp. 1891-1899. ISSN 1046-6673

Newby, P. R. and Roberts-Davies, E. L. and Brand, O. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2007) Tag SNP screening of the PDCD1 gene for association with Graves' disease. Clinical Endocrinology, 67 (1). pp. 125-128. ISSN 0300-0664

Newby, Paul R. and Pickles, Oliver J. and Mazumdar, Samaresh and Brand, Oliver J. and Carr-Smith, Jacqueline D. and Pearce, Simon H. S. and Franklyn, Jayne A. and Evans, David M. and Simmonds, Matthew J. and Gough, Stephen C. L. and Welcome Trust Case-Control Consortium (WTCCC), . (2010) Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study. European Journal of Human Genetics, 18 (9). pp. 1021-1026. ISSN 1018-4813

Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN 1553-7390

Simmonds, M. J. and Gough, S. C. L. (2004) Unravelling the genetic complexity of autoimmune thyroid disease: HLA, CTLA-4 and beyond. Clinical and Experimental Immunology, 136 (1). pp. 1-10. ISSN 0009-9104

Simmonds, M. J. and Heward, J. M. and Barrett, J. C. and Franklyn, J. A. and Gough, S. C. L. (2006) Association of the BTNL2 rs2076530 single nucleotide polymorphism with Graves' disease appears to be secondary to DRB1 exon 2 position beta74. Clinical Endocrinology, 65 (4). pp. 429-432. ISSN 0300-0664

Simmonds, M. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. (2005) The CD40 Kozak SNP: a new susceptibility loci for Graves' disease? Clinical Endocrinology, 63 (2). pp. 232-233. ISSN 0300 0664

Simmonds, M. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. (2005) IL-13 and chromosome 5q31-q33: problems of identifying association within regions of linkage to Graves' disease. Clinical Endocrinology, 63 (6). pp. 695-697. ISSN 0300-0664

Simmonds, M. J. and Heward, J.M. and Howson, J.M.M. and Foxall, H. and Nithiyananthan, R. and Franklyn, J.A. and Gough, S.C.L. (2004) A systematic approach to the assesment of known TNF-alpha polymorphisms in Graves' disease. Genes and Immunity, 5 (4). pp. 267-273. ISSN 1466-4879

Simmonds, M. J. and Howson, J. M. M. and Heward, J. M. and Carr-Smith, J. and Franklyn, J. A. and Todd, J. A. and Gough, S. C. L. (2007) A novel and major association of HLA-C in Graves' disease that eclipses the classical HLA-DRB1 effect. Human Molecular Genetics, 16 (18). pp. 2149-2153. ISSN 0964-6906

Simmonds, Matthew and Gough, S. C. L. (2005) Genetic insights into disease mechanisms of autoimmunity. British Medical Bulletin, 71 (1). pp. 93-113. ISSN 0007-1420

Simmonds, Matthew J. (2013) GWAS in autoimmune thyroid disease: redefining our understanding of pathogenesis. Nature Reviews Endocrinology, 9 (5). pp. 277-287. ISSN 1759-5029

Simmonds, Matthew J. and Benavente, David and Brand, Oliver J. and Moore, Jason and Ball, Simon and Ferro, Charles J. and Briggs, David and Gough, Stephen C. L. and Borrows, Richard J. (2013) Skewing of female X-chromosome inactivation: an epigenetic risk factor for kidney transplantation outcome. Transplantation, 95 (5). e25-e28. ISSN 0041-1337

Simmonds, Matthew J. and Brand, Oliver J. and Barrett, Jeffrey C. and Newby, Paul R. and Franklyn, Jayne A. and Gough, Stephen C. L. (2010) Association of Fc receptor-like 5 (FCRL5) with Graves' disease is secondary to the effect of FCRL3. Clinical Endocrinology, 73 (5). pp. 654-660. ISSN 0300-0664

Simmonds, Matthew J. and Gough, Stephen C. L. (2011) The search for the genetic contribution to autoimmune thyroid disease: The never ending story? Briefings in Functional Genomics, 10 (2). pp. 77-90. ISSN 2041-2649

Simmonds, Matthew J. and Heward, J. M. and Carr-Smith, J. and Foxall, H. and Franklyn, J. A. and Gough, S. C. L. (2006) Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease. Journal of Clinical Endocrinology and Metabolism, 91 (3). pp. 1056-1061. ISSN 0021-972X

Simmonds, Matthew J. and Heward, Joanne M. and Kelly, M. Ann and Allahabadia, Amit and Foxall, Helen and Gordon, Caroline and Franklyn, Jayne A. and Gough, Stephen C. L. (2002) A nonsense mutation in exon 2 of the DNase I gene is not present in UK subjects with systemic lupus erythematosus and Graves' disease: Comment on the article by Rood et al. Arthritis and Rheumatism, 46 (11). pp. 3109-3110. ISSN 0004-3591

Simmonds, Matthew J. and Howson, Joanna M. M. and Heward, Joanne M. and Cordell, Heather J. and Foxall, Helen and Carr-Smith, Jackie and Gibson, Sarah M. and Walker, Neil and Tomer, Yaron and Franklyn, Jayne A. and Todd, John A. and Gough, Stephen C. L. (2005) Regression mapping of association between the human leukocyte antigen region and Graves' disease. American Journal of Human Genetics, 76 (1). pp. 157-163. ISSN 0002-9297

Todd, J. A. and Walker, N. M. and Cooper, J. D. and Smyth, D. J. and Downes, K. and Plagnol, V. and Bailey, R. and Nejentsev, S. and Field, S. F. and Payne, F. and Lowe, C. E. and Szeszko, J. S. and Hafler, J. P. and Zeitels, L. and Yang, J. H. M. and Vella, A. and Nutland, S. and Stevens, H. E. and Schuilenburg, H. and Coleman, G. and Maisuria, M. and Meadows, W. and Smink, L. J. and Healy, B. and Burren, O. S. and Lam, A. A. C. and Ovington, N. R. and Allen, J. and Adlem, E. and Leung, H-T. and Wallace, C. and Howson, J. M. M. and Guja, C. and Ionescu-Tırgoviste, C. and Genetics of T1D in Finland, . and Simmonds, M. J. and Heward, J. M. and Gough, S. C. L. and WTCCC, . and Dunger, D. B. and Wicker, L. S. and Clayton, D. G. (2007) Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nature Genetics, 39 (7). pp. 857-864. ISSN 1061-4036

Yesmin, K. and Hargreaves, C. and Newby, P. R. and Brand, O. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2010) Association of FcGRIIa with Graves' disease: a potential role for dysregulated autoantibody clearance in disease onset/progression. Clinical Endocrinology, 73 (1). pp. 119-125. ISSN 0300-0664

Zeitlin, A. and Simmonds, M. J. and Gough, S. C. (2008) Genetic developments in autoimmune thyroid disease: an evolutionary process. Clinical Endocrinology, 68 (5). pp. 671-682. ISSN 0300-0664

Zeitlin, A. A. and Heward, J. M. and Brand, O. J. and Newby, P. R. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2006) Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. Clinical Endocrinology, 65 (3). pp. 380-384. ISSN 0300-0664

Zeitlin, A. A. and Heward, J. M. and Newby, P. R. and Carr-Smith, J. D. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2008) Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. Genes and Immunity, 9 (4). pp. 358-363. ISSN 1466-4879

I kappa B

Simmonds, Matthew J. and Heward, J. M. and Carr-Smith, J. and Foxall, H. and Franklyn, J. A. and Gough, S. C. L. (2006) Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease. Journal of Clinical Endocrinology and Metabolism, 91 (3). pp. 1056-1061. ISSN 0021-972X

IFIH1 gene

Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN 1553-7390

IL2 gene

Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN 1553-7390

IL27 insulinoma associated antigen 2 gene

Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN 1553-7390

IL2RA gene

Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN 1553-7390

Immunosuppressive Agents

Simmonds, Matthew and Gough, S. C. L. (2005) Genetic insights into disease mechanisms of autoimmunity. British Medical Bulletin, 71 (1). pp. 93-113. ISSN 0007-1420

Infant

Zeitlin, A. A. and Heward, J. M. and Brand, O. J. and Newby, P. R. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2006) Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. Clinical Endocrinology, 65 (3). pp. 380-384. ISSN 0300-0664

Inheritance Patterns

Simmonds, Matthew J. and Gough, Stephen C. L. (2011) The search for the genetic contribution to autoimmune thyroid disease: The never ending story? Briefings in Functional Genomics, 10 (2). pp. 77-90. ISSN 2041-2649

Interleukin-13

Simmonds, M. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. (2005) IL-13 and chromosome 5q31-q33: problems of identifying association within regions of linkage to Graves' disease. Clinical Endocrinology, 63 (6). pp. 695-697. ISSN 0300-0664

Intracranial volume

Ikram, M. Arfan and Fornage, Myriam and Smith, Albert V. and Seshadri, Sudha and Schmidt, Reinhold and Debette, Stéphanie and Vrooman, Henri A. and Sigurdsson, Sigurdur and Ropele, Stefan and Taal, H. Rob and Mook-Kanamori, Dennis O. and Coker, Laura H. and Longstreth, W. T. and Niessen, Wiro J. and DeStefano, Anita L. and Beiser, Alexa and Zijdenbos, Alex P. and Struchalin, Maksim and Jack, Clifford R. and Rivadeneira, Fernando and Uitterlinden, Andre G. and Knopman, David S. and Hartikainen, Anna-Liisa and Pennell, Craig E. and Thiering, Elisabeth and Steegers, Eric A. P. and Hakonarson, Hakon and Heinrich, Joachim and Palmer, Lyle J. and Jarvelin, Marjo-Riitta and McCarthy, Mark I. and Grant, Struan F. A. and Pourcain, Beate St and Timpson, Nicholas J. and Smith, George Davey and Sovio, Ulla and Nalls, Mike A. and Au, Rhoda and Hofman, Albert and Gudnason, Haukur and van der Lugt, Aad and Harris, Tamara B. and Meeks, William M. and Vernooij, Meike W. and van Buchem, Mark A. and Catellier, Diane and Jaddoe, Vincent W. V. and Gudnason, Vilmundur and Windham, B. Gwen and Wolf, Philip A. and van Duijn, Cornelia M. and Mosley, Thomas H. and Schmidt, Helena and Launer, Lenore J. and Breteler, Monique M. B. and DeCarli, Charles and Adair, Linda S. and Ang, Wei and Atalay, Mustafa and van Beijsterveldt, Toos and Bergen, Nienke and Benke, Kelly and Berry, Diane and Coin, Lachlan and Davis, Oliver S. P. and Elliott, Paul and Flexeder, Claudia and Frayling, Tim and Gaillard, Romy and Groen-Blokhuis, Maria and Goh, Liang-Kee and Haworth, Claire M. A. and Hadley, Dexter and Hedebrand, Johannes and Hinney, Anke and Hirschhorn, Joel N. and Holloway, John W. and Holst, Claus and Jan Hottenga, Jouke and Horikoshi, Momoko and Huikari, Ville and Hypponen, Elina and Kilpeläinen, Tuomas O. and Kirin, Mirna and Kowgier, Matthew and Lakka, Hanna-Maaria and Lange, Leslie A. and Lawlor, Debbie A. and Lehtimäki, Terho and Lewin, Alex and Lindgren, Cecilia and Lindi, Virpi and Maggi, Reedik and Marsh, Julie and Middeldorp, Christel and Millwood, Iona and Murray, Jeffrey C. and Nivard, Michel and Nohr, Ellen Aagaard and Ntalla, Ioanna and Oken, Emily and Panoutsopoulou, Kalliope and Pararajasingham, Jennifer and Rodriguez, Alina and Salem, Rany M. and Sebert, Sylvain and Siitonen, Niina and Strachan, David P. and Teo, Yik-Ying and Valcárcel, Beatriz and Willemsen, Gonneke and Zeggini, Eleftheria and Boomsma, Dorret I. and Cooper, Cyrus and Gillman, Matthew and Hocher, Berthold and Lakka, Timo A. and Mohlke, Karen L. and Dedoussis, George V. and Ong, Ken K. and Pearson, Ewan R. and Price, Thomas S. and Power, Chris and Raitakari, Olli T. and Saw, Seang-Mei and Scherag, Andre and Simell, Olli and Sørensen, Thorkild I. A. and Wilson, James F. (2012) Common variants at 6q22 and 17q21 are associated with intracranial volume. Nature Genetics, 44 (5). pp. 539-544. ISSN 1061-4036

Introns

Brand, O. J. and Barrett, J. C. and Simmonds, M. J. and Newby, P. R. and McCabe, C. J. and Bruce, C. K. and Kysela, B. and Carr-Smith, J. D. and Brix, T. and Hunt, P. J. and Wiersinga, W. M. and Hegedus, L. and Connell, J. and Wass, J. A. H. and Franklyn, J. A. and Weetman, A. P. and Heward, J. M. and Gough, S. C. L. (2009) Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves' disease. Human Molecular Genetics, 18 (9). pp. 1704-1713. ISSN 0964-6906

JSRP1 gene

Newby, Paul R. and Pickles, Oliver J. and Mazumdar, Samaresh and Brand, Oliver J. and Carr-Smith, Jacqueline D. and Pearce, Simon H. S. and Franklyn, Jayne A. and Evans, David M. and Simmonds, Matthew J. and Gough, Stephen C. L. and Welcome Trust Case-Control Consortium (WTCCC), . (2010) Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study. European Journal of Human Genetics, 18 (9). pp. 1021-1026. ISSN 1018-4813

Kaplan-Meier Estimate

Moore, Jason and McKnight, Amy Jayne and Döhler, Bernd and Simmonds, Matthew J. and Courtney, Aisling E. and Brand, Oliver J. and Briggs, David and Ball, Simon and Cockwell, Paul and Patterson, Christopher C. and Maxwell, Alexander P. and Gough, Stephen C. L. and Opelz, Gerhard and Borrows, Richard (2012) Donor ABCB1 variant associates with increased risk for kidney allograft failure. Journal of the American Society of Nephrology, 23 (11). pp. 1891-1899. ISSN 1046-6673

Kidney Transplantation

Chand, S. and Holle, J. U. and Hilhorst, M. and Simmonds, M. J. and Smith, S. and Kamesh, L. and Hewins, P. and McKnight, A. J. and Maxwell, A. P. and Willem Cohen Tervaert, J. and Wieczorek, S. and Harper, L. and Borrows, R. (2013) Caveolin-1 single nucleotide polymorphism in antineutrophil cytoplasmic antibody associated vasculitis. PLoS ONE, 8 (7). ISSN 1932-6203

Libyan Arab Jamahiriya

Elmrghni, Samir and Shaw, Michael and Ali, Nadir and Dixon, Ron and Ross Williams, D. (2012) Aberrations of human gender identification by amelogenin test in Libyans (Benghazi city). Indian Journal of Forensic Medicine and Toxicology, 6 (2). pp. 163-166. ISSN 0973-9122

Linkage Disequilibrium

Brand, O. J. and Barrett, J. C. and Simmonds, M. J. and Newby, P. R. and McCabe, C. J. and Bruce, C. K. and Kysela, B. and Carr-Smith, J. D. and Brix, T. and Hunt, P. J. and Wiersinga, W. M. and Hegedus, L. and Connell, J. and Wass, J. A. H. and Franklyn, J. A. and Weetman, A. P. and Heward, J. M. and Gough, S. C. L. (2009) Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves' disease. Human Molecular Genetics, 18 (9). pp. 1704-1713. ISSN 0964-6906

Moore, Jason and McKnight, Amy Jayne and Döhler, Bernd and Simmonds, Matthew J. and Courtney, Aisling E. and Brand, Oliver J. and Briggs, David and Ball, Simon and Cockwell, Paul and Patterson, Christopher C. and Maxwell, Alexander P. and Gough, Stephen C. L. and Opelz, Gerhard and Borrows, Richard (2012) Donor ABCB1 variant associates with increased risk for kidney allograft failure. Journal of the American Society of Nephrology, 23 (11). pp. 1891-1899. ISSN 1046-6673

Simmonds, M. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. (2005) IL-13 and chromosome 5q31-q33: problems of identifying association within regions of linkage to Graves' disease. Clinical Endocrinology, 63 (6). pp. 695-697. ISSN 0300-0664

Simmonds, M. J. and Heward, J.M. and Howson, J.M.M. and Foxall, H. and Nithiyananthan, R. and Franklyn, J.A. and Gough, S.C.L. (2004) A systematic approach to the assesment of known TNF-alpha polymorphisms in Graves' disease. Genes and Immunity, 5 (4). pp. 267-273. ISSN 1466-4879

Simmonds, Matthew J. and Brand, Oliver J. and Barrett, Jeffrey C. and Newby, Paul R. and Franklyn, Jayne A. and Gough, Stephen C. L. (2010) Association of Fc receptor-like 5 (FCRL5) with Graves' disease is secondary to the effect of FCRL3. Clinical Endocrinology, 73 (5). pp. 654-660. ISSN 0300-0664

Zeitlin, A. A. and Heward, J. M. and Newby, P. R. and Carr-Smith, J. D. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2008) Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. Genes and Immunity, 9 (4). pp. 358-363. ISSN 1466-4879

Linkage disequilibrium

Hamilton, Alexander and Gough, Stephen C. L. and Simmonds, Matthew J. (2013) Genetics of Graves’ disease. In: eLS - Encyclopedia of Life Sciences. Wiley. ISBN 9780470015902

Logistic Models

Simmonds, Matthew J. and Brand, Oliver J. and Barrett, Jeffrey C. and Newby, Paul R. and Franklyn, Jayne A. and Gough, Stephen C. L. (2010) Association of Fc receptor-like 5 (FCRL5) with Graves' disease is secondary to the effect of FCRL3. Clinical Endocrinology, 73 (5). pp. 654-660. ISSN 0300-0664

Lupus Erythematosus, Systemic

Simmonds, Matthew J. and Heward, Joanne M. and Kelly, M. Ann and Allahabadia, Amit and Foxall, Helen and Gordon, Caroline and Franklyn, Jayne A. and Gough, Stephen C. L. (2002) A nonsense mutation in exon 2 of the DNase I gene is not present in UK subjects with systemic lupus erythematosus and Graves' disease: Comment on the article by Rood et al. Arthritis and Rheumatism, 46 (11). pp. 3109-3110. ISSN 0004-3591

MAGI3 gene

Medici, M. and Porcu, E. and Pistis, G. and Teumer, A. and Brown, S. J. and Jensen, R. A. and Rawal, R. and Roef, G. L. and Plantinga, T. S. and Vermeulen, S. H. and Lahti, J. and Simmonds, M. J. and Husemoen, L. N. N. and Freathy, R. M. and Shields, B. M. and Pietzner, D. and Nagy, R. and Broer, L. and Chaker, L. and Korevaar, T. I. M. and Plia, M. G. and Sala, C. and Volker, U. and Richards, J. B. and Sweep, F. C. and Gieger, C. and Corre, T. and Kajantie, E. and Thuesen, B. and Taes, Y. E. and Visser, W. E. and Hattersley, A. T. and Kratzsch, J. and Hamilton, A. and Li, W. and Homuth, G. and Lobina, M. and Mariotti, S. and Soranzo, N. and Cocca, M. and Nauck, M. and Spielhagen, C. and Ross, A. and Arnold, A. and van de Bunt, M. and Liyanarachchi, S. and Heier, M. and Grabe, H. J. and Masciullo, C. and Galesloot, T. E. and Lim, E. M. and Reischl, E. and Leedman, P. J. and Lai, S. and Delitala, A. and Bremner, A. P. and Philips, D. I. W. and Beilby, J. P. and Mulas, A. and Vocale, M. and Abecasis, G. and Forsen, T. and James, A. and Widen, E. and Hui, J. and Prokisch, H. and Rietzschel, E. E. and Palotie, A. and Feddema, P. and Fletcher, S. J. and Schramm, K. and Rotter, J. I. and Kluttig, A. and Radke, D. and Traglia, M. and Surdulescu, G. L. and He, H. and Franklyn, J. A. and Tiller, D. and Vaidya, B. and de Meyer, T. and Jørgensen, T. and Eriksson, J. G. and O’Leary, P. C. and Wichmann, E. and Hermus, A. R. and Psaty, B. M. and Ittermann, T. and Hofman, A. and Bosi, E. and Schlessinger, D. and Wallaschofski, H. and Pirastu, N. and Aulchenko, Y.S. and de la Chapelle, A. and Netea-Maier, R.T. and Gough, S.C.L. and Meyer zu Schwabedissen, H. and Frayling, T.M. and Kaufman, J.M. and Linneberg, A. and Raikkonen, K. and Smit, J.W.A. and Kiemeney, L.A. and Rivadeneira, F. and Uitterlinden, A.G. and Walsh, J.P. and Meisinger, C. and den Heijer, M. and Visser, T.J. and Spector, T.D. and Wilson, S.G. and Volzke, H. and Cappola, A. and Toniolo, D. and Sanna, S. and Naitza, S. and Peeters, R.P. (2014) Identification of novel genetic loci associated with thyroid peroxidase antibodies and clinical thyroid disease. PLoS Genetics, 10 (2). ISSN 15537390

Major Histocompatibility Complex

Simmonds, M. J. and Gough, S. C. L. (2004) Unravelling the genetic complexity of autoimmune thyroid disease: HLA, CTLA-4 and beyond. Clinical and Experimental Immunology, 136 (1). pp. 1-10. ISSN 0009-9104

Mantel Haenszel test

Simmonds, M. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. (2005) The CD40 Kozak SNP: a new susceptibility loci for Graves' disease? Clinical Endocrinology, 63 (2). pp. 232-233. ISSN 0300 0664

Membrane Glycoproteins

Simmonds, M. J. and Heward, J. M. and Barrett, J. C. and Franklyn, J. A. and Gough, S. C. L. (2006) Association of the BTNL2 rs2076530 single nucleotide polymorphism with Graves' disease appears to be secondary to DRB1 exon 2 position beta74. Clinical Endocrinology, 65 (4). pp. 429-432. ISSN 0300-0664

Membrane Proteins

Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN 1553-7390

Mice

Simmonds, M. J. and Gough, S. C. L. (2004) Unravelling the genetic complexity of autoimmune thyroid disease: HLA, CTLA-4 and beyond. Clinical and Experimental Immunology, 136 (1). pp. 1-10. ISSN 0009-9104

Middle Aged

Boelaert, Kristien and Newby, Paul R. and Simmonds, Matthew J. and Holder, Roger L. and Carr-Smith, Jacqueline D. and Heward, Joanne M. and Manji, Nilusha and Allahabadia, Amit and Armitage, Mary and Chatterjee, Krishna V. and Lazarus, John H. and Pearce, Simon H. and Vaidya, Bijay and Gough, Stephen C. and Franklyn, Jayne A. (2010) Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease. American Journal of Medicine, 123 (2). 183.e1-183.e9. ISSN 0002-9343

Chand, S. and Holle, J. U. and Hilhorst, M. and Simmonds, M. J. and Smith, S. and Kamesh, L. and Hewins, P. and McKnight, A. J. and Maxwell, A. P. and Willem Cohen Tervaert, J. and Wieczorek, S. and Harper, L. and Borrows, R. (2013) Caveolin-1 single nucleotide polymorphism in antineutrophil cytoplasmic antibody associated vasculitis. PLoS ONE, 8 (7). ISSN 1932-6203

Moore, Jason and McKnight, Amy Jayne and Döhler, Bernd and Simmonds, Matthew J. and Courtney, Aisling E. and Brand, Oliver J. and Briggs, David and Ball, Simon and Cockwell, Paul and Patterson, Christopher C. and Maxwell, Alexander P. and Gough, Stephen C. L. and Opelz, Gerhard and Borrows, Richard (2012) Donor ABCB1 variant associates with increased risk for kidney allograft failure. Journal of the American Society of Nephrology, 23 (11). pp. 1891-1899. ISSN 1046-6673

Simmonds, Matthew J. and Brand, Oliver J. and Barrett, Jeffrey C. and Newby, Paul R. and Franklyn, Jayne A. and Gough, Stephen C. L. (2010) Association of Fc receptor-like 5 (FCRL5) with Graves' disease is secondary to the effect of FCRL3. Clinical Endocrinology, 73 (5). pp. 654-660. ISSN 0300-0664

Yesmin, K. and Hargreaves, C. and Newby, P. R. and Brand, O. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2010) Association of FcGRIIa with Graves' disease: a potential role for dysregulated autoantibody clearance in disease onset/progression. Clinical Endocrinology, 73 (1). pp. 119-125. ISSN 0300-0664

Models, Genetic

Hunt, K. A. and Mistry, V. and Bockett, N. A. and Ahmad, T. and Ban, M. and Barker, J. N. and Barrett, J. C. and Blackburn, H. and Brand, O. J. and Burren, O. and Capon, F. and Compston, A. and Gough, S. C. L. and Jostins, L. and Kong, Y. and Lee, J. C. and Lek, M. and MacArthur, D. G. and Mansfield, J. C. and Mathew, C. G. and Mein, C. A. and Mirza, M. and Nutland, S. and Onengut-Gumuscu, S. and Papouli, E. and Parkes, M. and Rich, S. S. and Sawcer, S. and Satsangi, J. and Simmonds, M. J. and Trembath, R. C. and Walker, N. M. and Wozniak, E. and Todd, J. A. and Simpson, M. A. and Plagnol, V. and van Heel, D. A. (2013) Negligible impact of rare autoimmune-locus coding-region variants on missing heritability. Nature, 498 (7453). pp. 232-235. ISSN 0028-0836

Mutation

Hunt, K. A. and Mistry, V. and Bockett, N. A. and Ahmad, T. and Ban, M. and Barker, J. N. and Barrett, J. C. and Blackburn, H. and Brand, O. J. and Burren, O. and Capon, F. and Compston, A. and Gough, S. C. L. and Jostins, L. and Kong, Y. and Lee, J. C. and Lek, M. and MacArthur, D. G. and Mansfield, J. C. and Mathew, C. G. and Mein, C. A. and Mirza, M. and Nutland, S. and Onengut-Gumuscu, S. and Papouli, E. and Parkes, M. and Rich, S. S. and Sawcer, S. and Satsangi, J. and Simmonds, M. J. and Trembath, R. C. and Walker, N. M. and Wozniak, E. and Todd, J. A. and Simpson, M. A. and Plagnol, V. and van Heel, D. A. (2013) Negligible impact of rare autoimmune-locus coding-region variants on missing heritability. Nature, 498 (7453). pp. 232-235. ISSN 0028-0836

NBS1

Xing, Meichun and Wang, Xiaohui and Palmai-Pallag, Timea and Shen, Huahao and Helleday, Thomas and Hickson, Ian D. and Ying, Songmin (2015) Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response. Oncotarget, 6 (35). pp. 37638-37646. ISSN 1949-2553

NR1I2 gene

Moore, Jason and McKnight, Amy Jayne and Döhler, Bernd and Simmonds, Matthew J. and Courtney, Aisling E. and Brand, Oliver J. and Briggs, David and Ball, Simon and Cockwell, Paul and Patterson, Christopher C. and Maxwell, Alexander P. and Gough, Stephen C. L. and Opelz, Gerhard and Borrows, Richard (2012) Donor ABCB1 variant associates with increased risk for kidney allograft failure. Journal of the American Society of Nephrology, 23 (11). pp. 1891-1899. ISSN 1046-6673

Neurodegeneration

Taal, H. Rob and St Pourcain, Beate and Thiering, Elisabeth and Das, Shikta and Mook-Kanamori, Dennis O. and Warrington, Nicole M. and Kaakinen, Marika and Kreiner-Møller, Eskil and Bradfield, Jonathan P. and Freathy, Rachel M. and Geller, Frank and Guxens, Mònica and Cousminer, Diana L. and Kerkhof, Marjan and Timpson, Nicholas J. and Ikram, M. Arfan and Beilin, Lawrence J. and Bønnelykke, Klaus and Buxton, Jessica L. and Charoen, Pimphen and Chawes, Bo Lund Krogsgaard and Eriksson, Johan and Evans, David M. and Hofman, Albert and Kemp, John P. and Kim, Cecilia E. and Klopp, Norman and Lahti, Jari and Lye, Stephen J. and McMahon, George and Mentch, Frank D. and Müller-Nurasyid, Martina and O'Reilly, Paul F. and Prokopenko, Inga and Rivadeneira, Fernando and Steegers, Eric A. P. and Sunyer, Jordi and Tiesler, Carla and Yaghootkar, Hanieh and Fornage, Myriam and Smith, Albert V. and Seshadri, Sudha and Schmidt, Reinhold and Debette, Stéphanie and Vrooman, Henri A. and Sigurdsson, Sigurdur and Ropele, Stefan and Coker, Laura H. and Longstreth, W. T. and Niessen, Wiro J. and DeStefano, Anita L. and Beiser, Alexa and Zijdenbos, Alex P. and Struchalin, Maksim and Jack, Clifford R. and Nalls, Mike A. and Au, Rhoda and Gudnason, Haukur and van der Lugt, Aad and Harris, Tamara B. and Meeks, William M. and Vernooij, Meike W. and van Buchem, Mark A. and Catellier, Diane and Gudnason, Vilmundur and Windham, B. Gwen and Wolf, Philip A. and van Duijn, Cornelia M. and Mosley, Thomas H. and Schmidt, Helena and Launer, Lenore J. and Breteler, Monique M. B. and DeCarli, Charles and Mosley, Thomas and Ang, Wei and van Beijsterveldt, Toos and Bergen, Nienke and Benke, Kelly and Berry, Diane and Coin, Lachlan and Elliott, Paul and Frayling, Tim and Gaillard, Romy and Groen-Blokhuis, Maria and Hadley, Dexter and Hottenga, Jouke Jan and Huikari, Ville and Hypponen, Elina and Kowgier, Matthew and Lawlor, Debbie A. and Lewin, Alex and Lindgren, Cecilia and Marsh, Julie and Middeldorp, Christel and Millwood, Iona and Nivard, Michel and Palmer, Lyle J. and Rodriguez, Alina and Sebert, Sylvain and Standl, Marie and Strachan, David P. and Uitterlinden, Andre G. and Valcárcel, Beatriz and White, Scott and Willemsen, Gonneke and Boomsma, Dorret I. and Grant, Struan F. A. and Hakonarson, Hakon and Hattersley, Andrew T. and Heinrich, Joachim and Jaddoe, Vincent W. V. and McCarthy, Mark I. and Pennell, Craig E. and Power, Chris and Widen, Elisabeth and Blakemore, Alexandra I. F. and Chiavacci, Rosetta M. and Feenstra, Bjarke and Fernandez-Banet, Julio and Hartikainen, Anna-Liisa and van der Heijden, Albert J. and Iñiguez, Carmen and Lathrop, Mark and McArdle, Wendy L. and Mølgaard, Anne and Newnham, John P. and Palotie, Aarno and Pouta, Annneli and Ring, Susan M. and Sovio, Ulla and Wichmann, H-Erich and Vissing, Nadja Hawwa and van Duijn, Cornelia M. and Koppelman, Gerard H. and Melbye, Mads and Bisgaard, Hans and Smith, George Davey and Adair, Linda S. and Atalay, Mustafa and Davis, Oliver S. P. and Flexeder, Claudia and Goh, Liang-Kee and Haworth, Claire M. A. and Hedebrand, Johannes and Hinney, Anke and Hirschhorn, Joel N. and Holloway, John W. and Holst, Claus and Horikoshi, Momoko and Kilpeläinen, Tuomas O. and Kirin, Mirna and Lakka, Hanna-Maaria and Lange, Leslie A. and Lehtimäki, Terho and Lindi, Virpi and Maggi, Reedik and Murray, Jeffrey C. and Nohr, Ellen Aagaard and Ntalla, Ioanna and Oken, Emily and Panoutsopoulou, Kalliope and Pararajasingham, Jennifer and Salem, Rany M. and Siitonen, Niina and Teo, Yik-Ying and Zeggini, Eleftheria and Cooper, Cyrus and Estivill, Xavier and Gillman, Matthew and Hocher, Berthold and Jarvelin, Marjo-Riitta and Lakka, Timo A. and Mohlke, Karen L. and Dedoussis, George V. and Ong, Ken K. and Pearson, Ewan R. and Price, Thomas S. and Raitakari, Olli T. and Saw, Seang-Mei and Scherag, Andre and Simell, Olli and Sørensen, Thorkild I. A. and Wilson, James F. (2012) Common variants at 12q15 and 12q24 are associated with infant head circumference. Nature Genetics, 44 (5). pp. 532-538. ISSN 1061-4036

Neuroscience

St Pourcain, Beate and Cents, Rolieke A. M. and Whitehouse, Andrew J. O. and Haworth, Claire M. A. and Davis, Oliver S. P. and O’Reilly, Paul F. and Roulstone, Susan and Wren, Yvonne and Ang, Qi W. and Velders, Fleur P. and Evans, David M. and Kemp, John P. and Warrington, Nicole M. and Miller, Laura and Timpson, Nicholas J. and Ring, Susan M. and Verhulst, Frank C. and Hofman, Albert and Rivadeneira, Fernando and Meaburn, Emma L. and Price, Thomas S. and Dale, Philip S. and Pillas, Demetris and Yliherva, Anneli and Rodriguez, Alina and Golding, Jean and Jaddoe, Vincent W. V. and Jarvelin, Marjo-Riitta and Plomin, Robert and Pennell, Craig E. and Tiemeier, Henning and Davey Smith, George (2014) Common variation near ROBO2 is associated with expressive vocabulary in infancy. Nature Communications, 5 . p. 4831. ISSN 2041-1723

Odds Ratio

Hafler, J. P. and Maier, L. M. and Cooper, J. D. and Plagnol, V. and Hinks, A. and Simmonds, M. J. and Stevens, H. and Walker, N. and Healy, B. and Howson, J. M. M. and Maisuria, M. and Duley, S. and Coleman, G. and Gough, S. C. L. and Worthington, J. and Kuchroo, V. K. and Wicker, L. S. and Todd, J. A. and IMSGC, . (2009) CD226 Gly307Ser association with multiple autoimmune diseases. Genes and Immunity, 10 (1). pp. 5-10. ISSN 1466-4879

Newby, P. R. and Roberts-Davies, E. L. and Brand, O. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2007) Tag SNP screening of the PDCD1 gene for association with Graves' disease. Clinical Endocrinology, 67 (1). pp. 125-128. ISSN 0300-0664

Simmonds, M. J. and Heward, J. M. and Barrett, J. C. and Franklyn, J. A. and Gough, S. C. L. (2006) Association of the BTNL2 rs2076530 single nucleotide polymorphism with Graves' disease appears to be secondary to DRB1 exon 2 position beta74. Clinical Endocrinology, 65 (4). pp. 429-432. ISSN 0300-0664

Simmonds, Matthew J. and Howson, Joanna M. M. and Heward, Joanne M. and Cordell, Heather J. and Foxall, Helen and Carr-Smith, Jackie and Gibson, Sarah M. and Walker, Neil and Tomer, Yaron and Franklyn, Jayne A. and Todd, John A. and Gough, Stephen C. L. (2005) Regression mapping of association between the human leukocyte antigen region and Graves' disease. American Journal of Human Genetics, 76 (1). pp. 157-163. ISSN 0002-9297

Zeitlin, A. A. and Heward, J. M. and Brand, O. J. and Newby, P. R. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2006) Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. Clinical Endocrinology, 65 (3). pp. 380-384. ISSN 0300-0664

Zeitlin, A. A. and Heward, J. M. and Newby, P. R. and Carr-Smith, J. D. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2008) Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. Genes and Immunity, 9 (4). pp. 358-363. ISSN 1466-4879

Open Reading Frames

Hunt, K. A. and Mistry, V. and Bockett, N. A. and Ahmad, T. and Ban, M. and Barker, J. N. and Barrett, J. C. and Blackburn, H. and Brand, O. J. and Burren, O. and Capon, F. and Compston, A. and Gough, S. C. L. and Jostins, L. and Kong, Y. and Lee, J. C. and Lek, M. and MacArthur, D. G. and Mansfield, J. C. and Mathew, C. G. and Mein, C. A. and Mirza, M. and Nutland, S. and Onengut-Gumuscu, S. and Papouli, E. and Parkes, M. and Rich, S. S. and Sawcer, S. and Satsangi, J. and Simmonds, M. J. and Trembath, R. C. and Walker, N. M. and Wozniak, E. and Todd, J. A. and Simpson, M. A. and Plagnol, V. and van Heel, D. A. (2013) Negligible impact of rare autoimmune-locus coding-region variants on missing heritability. Nature, 498 (7453). pp. 232-235. ISSN 0028-0836

P-Glycoprotein

Moore, Jason and McKnight, Amy Jayne and Döhler, Bernd and Simmonds, Matthew J. and Courtney, Aisling E. and Brand, Oliver J. and Briggs, David and Ball, Simon and Cockwell, Paul and Patterson, Christopher C. and Maxwell, Alexander P. and Gough, Stephen C. L. and Opelz, Gerhard and Borrows, Richard (2012) Donor ABCB1 variant associates with increased risk for kidney allograft failure. Journal of the American Society of Nephrology, 23 (11). pp. 1891-1899. ISSN 1046-6673

PCA gene

Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN 1553-7390

PICH

Nielsen, Christian F. and Huttner, Diana and Bizard, Anna H. and Hirano, Seiki and Li, Tian-Neng and Palmai-Pallag, Timea and Bjerregaard, Victoria A. and Liu, Ying and Nigg, Erich A. and Wang, Lily Hui-Ching and Hickson, Ian D. (2015) PICH promotes sister chromatid disjunction and co-operates with topoisomerase II in mitosis. Nature Communications, 6 . p. 8962. ISSN 2041-1723

PPIA gene

Moore, Jason and McKnight, Amy Jayne and Döhler, Bernd and Simmonds, Matthew J. and Courtney, Aisling E. and Brand, Oliver J. and Briggs, David and Ball, Simon and Cockwell, Paul and Patterson, Christopher C. and Maxwell, Alexander P. and Gough, Stephen C. L. and Opelz, Gerhard and Borrows, Richard (2012) Donor ABCB1 variant associates with increased risk for kidney allograft failure. Journal of the American Society of Nephrology, 23 (11). pp. 1891-1899. ISSN 1046-6673

PTPN22 gene

Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN 1553-7390

Pakistan

Ali, Nadir and Coulson-Thomas, Yvette M. and Norton, Andrew L. and Dixon, Ronald A. and Williams, D. Ross (2013) Announcement of population data: genetic data for 17 Y-STR AmpFℓSTR® Yfiler™ markers from an immigrant Pakistani population in the UK (British Pakistanis). Forensic Science International: Genetics, 7 (2). e40-e42. ISSN 1872-4973

Parafibromin

Herr, Patrick and Lundin, Cecilia and Evers, Bastiaan and Ebner, Daniel and Bauerschmidt, Christina and Kingham, Guy and Palmai-Pallag, Timea and Mortusewicz, Oliver and Frings, Oliver and Sonnhammer, Erik and Helleday, Thomas (2015) A genome-wide IR-induced RAD51 foci RNAi screen identifies CDC73 involved in chromatin remodeling for DNA repair. Cell Discovery . p. 15034. ISSN 2056-5968

Phenotype

Simmonds, Matthew J. and Heward, J. M. and Carr-Smith, J. and Foxall, H. and Franklyn, J. A. and Gough, S. C. L. (2006) Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease. Journal of Clinical Endocrinology and Metabolism, 91 (3). pp. 1056-1061. ISSN 0021-972X

Physical Chromosome Mapping

Hafler, J. P. and Maier, L. M. and Cooper, J. D. and Plagnol, V. and Hinks, A. and Simmonds, M. J. and Stevens, H. and Walker, N. and Healy, B. and Howson, J. M. M. and Maisuria, M. and Duley, S. and Coleman, G. and Gough, S. C. L. and Worthington, J. and Kuchroo, V. K. and Wicker, L. S. and Todd, J. A. and IMSGC, . (2009) CD226 Gly307Ser association with multiple autoimmune diseases. Genes and Immunity, 10 (1). pp. 5-10. ISSN 1466-4879

Polymerase Chain Reaction

Simmonds, Matthew J. and Heward, J. M. and Carr-Smith, J. and Foxall, H. and Franklyn, J. A. and Gough, S. C. L. (2006) Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease. Journal of Clinical Endocrinology and Metabolism, 91 (3). pp. 1056-1061. ISSN 0021-972X

Polymorphism, Genetic

Moore, J. and McKnight, A.J. and Simmonds, M. J. and Courtney, A. E. and Hanvesakul, R. and Brand, O. J. and Briggs, D. and Ball, S. and Cockwell, P. and Patterson, C.C. and Maxwell, A. P. and Gough, S. C. L. and Borrows, R. (2010) Association of caveolin-1 gene polymorphism with kidney transplant fibrosis and allograft failure. JAMA - Journal of the American Medical Association, 303 (13). pp. 1282-1287. ISSN 0098-7484

Simmonds, M. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. (2005) IL-13 and chromosome 5q31-q33: problems of identifying association within regions of linkage to Graves' disease. Clinical Endocrinology, 63 (6). pp. 695-697. ISSN 0300-0664

Simmonds, M. J. and Heward, J.M. and Howson, J.M.M. and Foxall, H. and Nithiyananthan, R. and Franklyn, J.A. and Gough, S.C.L. (2004) A systematic approach to the assesment of known TNF-alpha polymorphisms in Graves' disease. Genes and Immunity, 5 (4). pp. 267-273. ISSN 1466-4879

Simmonds, Matthew J. and Howson, Joanna M. M. and Heward, Joanne M. and Cordell, Heather J. and Foxall, Helen and Carr-Smith, Jackie and Gibson, Sarah M. and Walker, Neil and Tomer, Yaron and Franklyn, Jayne A. and Todd, John A. and Gough, Stephen C. L. (2005) Regression mapping of association between the human leukocyte antigen region and Graves' disease. American Journal of Human Genetics, 76 (1). pp. 157-163. ISSN 0002-9297

Polymorphism, Restriction Fragment Length

Heward, J. M. and Simmonds, M. J. and Carr-Smith, J. and Foxall, H. and Franklyn, J. A. and Gough, S. C. L. (2004) A single nucleotide polymorphism in the CD40 gene on chromosome 20q (GD-2) provides no evidence for susceptibility to Graves' disease in UK Caucasians. Clinical Endocrinology, 61 (2). pp. 269-272. ISSN 0300-0664

Simmonds, Matthew J. and Heward, J. M. and Carr-Smith, J. and Foxall, H. and Franklyn, J. A. and Gough, S. C. L. (2006) Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease. Journal of Clinical Endocrinology and Metabolism, 91 (3). pp. 1056-1061. ISSN 0021-972X

Polymorphism, Single Nucleotide

Brand, O. J. and Barrett, J. C. and Simmonds, M. J. and Newby, P. R. and McCabe, C. J. and Bruce, C. K. and Kysela, B. and Carr-Smith, J. D. and Brix, T. and Hunt, P. J. and Wiersinga, W. M. and Hegedus, L. and Connell, J. and Wass, J. A. H. and Franklyn, J. A. and Weetman, A. P. and Heward, J. M. and Gough, S. C. L. (2009) Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves' disease. Human Molecular Genetics, 18 (9). pp. 1704-1713. ISSN 0964-6906

Chand, S. and Holle, J. U. and Hilhorst, M. and Simmonds, M. J. and Smith, S. and Kamesh, L. and Hewins, P. and McKnight, A. J. and Maxwell, A. P. and Willem Cohen Tervaert, J. and Wieczorek, S. and Harper, L. and Borrows, R. (2013) Caveolin-1 single nucleotide polymorphism in antineutrophil cytoplasmic antibody associated vasculitis. PLoS ONE, 8 (7). ISSN 1932-6203

Cooper, J. D. and Simmonds, M. J. and Walker, N.M. and Burren, O. and Brand, O.J. and Guo, H. and Wallace, C. and Stevens, H. and Coleman, G and Franklyn, J.A. and Todd, J.A. and Gough, S.C.L. (2012) Seven newly identified loci for autoimmune thyroid disease. Human Molecular Genetics, 21 (23). pp. 5202-5208. ISSN 0964-6906

Hafler, J. P. and Maier, L. M. and Cooper, J. D. and Plagnol, V. and Hinks, A. and Simmonds, M. J. and Stevens, H. and Walker, N. and Healy, B. and Howson, J. M. M. and Maisuria, M. and Duley, S. and Coleman, G. and Gough, S. C. L. and Worthington, J. and Kuchroo, V. K. and Wicker, L. S. and Todd, J. A. and IMSGC, . (2009) CD226 Gly307Ser association with multiple autoimmune diseases. Genes and Immunity, 10 (1). pp. 5-10. ISSN 1466-4879

Heward, J. M. and Simmonds, M. J. and Carr-Smith, J. and Foxall, H. and Franklyn, J. A. and Gough, S. C. L. (2004) A single nucleotide polymorphism in the CD40 gene on chromosome 20q (GD-2) provides no evidence for susceptibility to Graves' disease in UK Caucasians. Clinical Endocrinology, 61 (2). pp. 269-272. ISSN 0300-0664

Moore, Jason and McKnight, Amy Jayne and Döhler, Bernd and Simmonds, Matthew J. and Courtney, Aisling E. and Brand, Oliver J. and Briggs, David and Ball, Simon and Cockwell, Paul and Patterson, Christopher C. and Maxwell, Alexander P. and Gough, Stephen C. L. and Opelz, Gerhard and Borrows, Richard (2012) Donor ABCB1 variant associates with increased risk for kidney allograft failure. Journal of the American Society of Nephrology, 23 (11). pp. 1891-1899. ISSN 1046-6673

Newby, P. R. and Roberts-Davies, E. L. and Brand, O. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2007) Tag SNP screening of the PDCD1 gene for association with Graves' disease. Clinical Endocrinology, 67 (1). pp. 125-128. ISSN 0300-0664

Newby, Paul R. and Pickles, Oliver J. and Mazumdar, Samaresh and Brand, Oliver J. and Carr-Smith, Jacqueline D. and Pearce, Simon H. S. and Franklyn, Jayne A. and Evans, David M. and Simmonds, Matthew J. and Gough, Stephen C. L. and Welcome Trust Case-Control Consortium (WTCCC), . (2010) Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study. European Journal of Human Genetics, 18 (9). pp. 1021-1026. ISSN 1018-4813

Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN 1553-7390

Simmonds, M. J. and Heward, J. M. and Barrett, J. C. and Franklyn, J. A. and Gough, S. C. L. (2006) Association of the BTNL2 rs2076530 single nucleotide polymorphism with Graves' disease appears to be secondary to DRB1 exon 2 position beta74. Clinical Endocrinology, 65 (4). pp. 429-432. ISSN 0300-0664

Simmonds, M. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. (2005) The CD40 Kozak SNP: a new susceptibility loci for Graves' disease? Clinical Endocrinology, 63 (2). pp. 232-233. ISSN 0300 0664

Simmonds, M. J. and Heward, J.M. and Howson, J.M.M. and Foxall, H. and Nithiyananthan, R. and Franklyn, J.A. and Gough, S.C.L. (2004) A systematic approach to the assesment of known TNF-alpha polymorphisms in Graves' disease. Genes and Immunity, 5 (4). pp. 267-273. ISSN 1466-4879

Simmonds, Matthew J. (2013) GWAS in autoimmune thyroid disease: redefining our understanding of pathogenesis. Nature Reviews Endocrinology, 9 (5). pp. 277-287. ISSN 1759-5029

Simmonds, Matthew J. and Brand, Oliver J. and Barrett, Jeffrey C. and Newby, Paul R. and Franklyn, Jayne A. and Gough, Stephen C. L. (2010) Association of Fc receptor-like 5 (FCRL5) with Graves' disease is secondary to the effect of FCRL3. Clinical Endocrinology, 73 (5). pp. 654-660. ISSN 0300-0664

Simmonds, Matthew J. and Heward, J. M. and Carr-Smith, J. and Foxall, H. and Franklyn, J. A. and Gough, S. C. L. (2006) Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease. Journal of Clinical Endocrinology and Metabolism, 91 (3). pp. 1056-1061. ISSN 0021-972X

Todd, J. A. and Walker, N. M. and Cooper, J. D. and Smyth, D. J. and Downes, K. and Plagnol, V. and Bailey, R. and Nejentsev, S. and Field, S. F. and Payne, F. and Lowe, C. E. and Szeszko, J. S. and Hafler, J. P. and Zeitels, L. and Yang, J. H. M. and Vella, A. and Nutland, S. and Stevens, H. E. and Schuilenburg, H. and Coleman, G. and Maisuria, M. and Meadows, W. and Smink, L. J. and Healy, B. and Burren, O. S. and Lam, A. A. C. and Ovington, N. R. and Allen, J. and Adlem, E. and Leung, H-T. and Wallace, C. and Howson, J. M. M. and Guja, C. and Ionescu-Tırgoviste, C. and Genetics of T1D in Finland, . and Simmonds, M. J. and Heward, J. M. and Gough, S. C. L. and WTCCC, . and Dunger, D. B. and Wicker, L. S. and Clayton, D. G. (2007) Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nature Genetics, 39 (7). pp. 857-864. ISSN 1061-4036

Yesmin, K. and Hargreaves, C. and Newby, P. R. and Brand, O. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2010) Association of FcGRIIa with Graves' disease: a potential role for dysregulated autoantibody clearance in disease onset/progression. Clinical Endocrinology, 73 (1). pp. 119-125. ISSN 0300-0664

Zeitlin, A. and Simmonds, M. J. and Gough, S. C. (2008) Genetic developments in autoimmune thyroid disease: an evolutionary process. Clinical Endocrinology, 68 (5). pp. 671-682. ISSN 0300-0664

Zeitlin, A. A. and Heward, J. M. and Brand, O. J. and Newby, P. R. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2006) Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. Clinical Endocrinology, 65 (3). pp. 380-384. ISSN 0300-0664

Population

Ali, Nadir and Coulson-Thomas, Yvette M. and Dixon, Ronald A. and Williams, D. Ross (2014) Genetic variation comparison of 15 autosomal STR loci in an immigrant population living in the UK (British Pakistanis) with an ancestral origin population from Pakistan. Forensic Science International: Genetics, 9 . e10-e12. ISSN 1872-4973

Protein Tyrosine Phosphatase, Non-Receptor Type 22

Zeitlin, A. A. and Heward, J. M. and Brand, O. J. and Newby, P. R. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2006) Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. Clinical Endocrinology, 65 (3). pp. 380-384. ISSN 0300-0664

Protein Tyrosine Phosphatases

Zeitlin, A. A. and Heward, J. M. and Brand, O. J. and Newby, P. R. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2006) Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. Clinical Endocrinology, 65 (3). pp. 380-384. ISSN 0300-0664

Protein-Tyrosine-Phosphatase

Zeitlin, A. A. and Heward, J. M. and Brand, O. J. and Newby, P. R. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2006) Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. Clinical Endocrinology, 65 (3). pp. 380-384. ISSN 0300-0664

Quantitative Trait Loci

Simmonds, M. J. and Howson, J. M. M. and Heward, J. M. and Carr-Smith, J. and Franklyn, J. A. and Todd, J. A. and Gough, S. C. L. (2007) A novel and major association of HLA-C in Graves' disease that eclipses the classical HLA-DRB1 effect. Human Molecular Genetics, 16 (18). pp. 2149-2153. ISSN 0964-6906

RAD51

Herr, Patrick and Lundin, Cecilia and Evers, Bastiaan and Ebner, Daniel and Bauerschmidt, Christina and Kingham, Guy and Palmai-Pallag, Timea and Mortusewicz, Oliver and Frings, Oliver and Sonnhammer, Erik and Helleday, Thomas (2015) A genome-wide IR-induced RAD51 foci RNAi screen identifies CDC73 involved in chromatin remodeling for DNA repair. Cell Discovery . p. 15034. ISSN 2056-5968

RASGRP1 gene

Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN 1553-7390

Receptors, Cell Surface

Simmonds, Matthew J. and Brand, Oliver J. and Barrett, Jeffrey C. and Newby, Paul R. and Franklyn, Jayne A. and Gough, Stephen C. L. (2010) Association of Fc receptor-like 5 (FCRL5) with Graves' disease is secondary to the effect of FCRL3. Clinical Endocrinology, 73 (5). pp. 654-660. ISSN 0300-0664

Receptors, IgG

Yesmin, K. and Hargreaves, C. and Newby, P. R. and Brand, O. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2010) Association of FcGRIIa with Graves' disease: a potential role for dysregulated autoantibody clearance in disease onset/progression. Clinical Endocrinology, 73 (1). pp. 119-125. ISSN 0300-0664

Receptors, Immunologic

Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN 1553-7390

Simmonds, Matthew J. and Brand, Oliver J. and Barrett, Jeffrey C. and Newby, Paul R. and Franklyn, Jayne A. and Gough, Stephen C. L. (2010) Association of Fc receptor-like 5 (FCRL5) with Graves' disease is secondary to the effect of FCRL3. Clinical Endocrinology, 73 (5). pp. 654-660. ISSN 0300-0664

Simmonds, Matthew J. and Heward, J. M. and Carr-Smith, J. and Foxall, H. and Franklyn, J. A. and Gough, S. C. L. (2006) Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease. Journal of Clinical Endocrinology and Metabolism, 91 (3). pp. 1056-1061. ISSN 0021-972X

Receptors, Steroid

Moore, Jason and McKnight, Amy Jayne and Döhler, Bernd and Simmonds, Matthew J. and Courtney, Aisling E. and Brand, Oliver J. and Briggs, David and Ball, Simon and Cockwell, Paul and Patterson, Christopher C. and Maxwell, Alexander P. and Gough, Stephen C. L. and Opelz, Gerhard and Borrows, Richard (2012) Donor ABCB1 variant associates with increased risk for kidney allograft failure. Journal of the American Society of Nephrology, 23 (11). pp. 1891-1899. ISSN 1046-6673

Receptors, Thyrotropin

Brand, O. J. and Barrett, J. C. and Simmonds, M. J. and Newby, P. R. and McCabe, C. J. and Bruce, C. K. and Kysela, B. and Carr-Smith, J. D. and Brix, T. and Hunt, P. J. and Wiersinga, W. M. and Hegedus, L. and Connell, J. and Wass, J. A. H. and Franklyn, J. A. and Weetman, A. P. and Heward, J. M. and Gough, S. C. L. (2009) Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves' disease. Human Molecular Genetics, 18 (9). pp. 1704-1713. ISSN 0964-6906

Simmonds, M. J. and Howson, J. M. M. and Heward, J. M. and Carr-Smith, J. and Franklyn, J. A. and Todd, J. A. and Gough, S. C. L. (2007) A novel and major association of HLA-C in Graves' disease that eclipses the classical HLA-DRB1 effect. Human Molecular Genetics, 16 (18). pp. 2149-2153. ISSN 0964-6906

Reference Values

Simmonds, Matthew J. and Heward, J. M. and Carr-Smith, J. and Foxall, H. and Franklyn, J. A. and Gough, S. C. L. (2006) Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease. Journal of Clinical Endocrinology and Metabolism, 91 (3). pp. 1056-1061. ISSN 0021-972X

Regression Analysis

Simmonds, Matthew J. and Howson, Joanna M. M. and Heward, Joanne M. and Cordell, Heather J. and Foxall, Helen and Carr-Smith, Jackie and Gibson, Sarah M. and Walker, Neil and Tomer, Yaron and Franklyn, Jayne A. and Todd, John A. and Gough, Stephen C. L. (2005) Regression mapping of association between the human leukocyte antigen region and Graves' disease. American Journal of Human Genetics, 76 (1). pp. 157-163. ISSN 0002-9297

Risk

Boelaert, Kristien and Newby, Paul R. and Simmonds, Matthew J. and Holder, Roger L. and Carr-Smith, Jacqueline D. and Heward, Joanne M. and Manji, Nilusha and Allahabadia, Amit and Armitage, Mary and Chatterjee, Krishna V. and Lazarus, John H. and Pearce, Simon H. and Vaidya, Bijay and Gough, Stephen C. and Franklyn, Jayne A. (2010) Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease. American Journal of Medicine, 123 (2). 183.e1-183.e9. ISSN 0002-9343

Simmonds, M. J. and Heward, J. M. and Barrett, J. C. and Franklyn, J. A. and Gough, S. C. L. (2006) Association of the BTNL2 rs2076530 single nucleotide polymorphism with Graves' disease appears to be secondary to DRB1 exon 2 position beta74. Clinical Endocrinology, 65 (4). pp. 429-432. ISSN 0300-0664

Risk Factors

Chand, S. and Holle, J. U. and Hilhorst, M. and Simmonds, M. J. and Smith, S. and Kamesh, L. and Hewins, P. and McKnight, A. J. and Maxwell, A. P. and Willem Cohen Tervaert, J. and Wieczorek, S. and Harper, L. and Borrows, R. (2013) Caveolin-1 single nucleotide polymorphism in antineutrophil cytoplasmic antibody associated vasculitis. PLoS ONE, 8 (7). ISSN 1932-6203

Hunt, K. A. and Smyth, D. J. and Balschun, T. and Ban, M. and Mistry, V. and Ahmed, T. and Barrett, J. C. and Bhaw-Rosun, L. and Bockett, N. A. and Brand, O. J. and Brouwer, E. and Concannon, P. and Cooper, J. D. and Dias, K-R. M. and van Diemen, C. C. and Dubois, P.C. and Edkins, S. and Fölster-Holst, R. and Fransen, K. and Glass, D. N. and Heap, G. A. R. and Hofmann, S. and Huizinga, T. W. J. and Hunt, S. and Langford, C. and Lee, J. and Mansfield, J. and Giovanna Marrosu, M. and Mathew, C. G. and Mein, C.A. and Müller-Quernheim, J. and Nutland, S. and Onengut-Gumuscu, S. and Ouwehand, W. and Pearce, K. and Prescott, N. and Posthumus, M. D. and Potter, S. and Rosati, G. and Sambrook, J. and Satsangi, J. and Schreiber, S. and Shtir, C. and Simmonds, M. J. and Sudman, M. and Thompson, S. D. and Toes, R. and Trynka, G. and Vyse, T. J. and Walker, N. M. and Weidinger, S. and Zhernakova, A. and Zoledziewska, M. and Weersma, R.K. and Gough, S.C.L. and Sawcer, S. and Wijmenga, C. and Parkes, M. and Cucca, F. and Franke, A. and Deloukas, P. and Rich, S. S. and Todd, J. A. and van Heel, D. A. (2011) Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry. Nature Genetics, 44 (1). pp. 3-5. ISSN 10614036

Medici, M. and Porcu, E. and Pistis, G. and Teumer, A. and Brown, S. J. and Jensen, R. A. and Rawal, R. and Roef, G. L. and Plantinga, T. S. and Vermeulen, S. H. and Lahti, J. and Simmonds, M. J. and Husemoen, L. N. N. and Freathy, R. M. and Shields, B. M. and Pietzner, D. and Nagy, R. and Broer, L. and Chaker, L. and Korevaar, T. I. M. and Plia, M. G. and Sala, C. and Volker, U. and Richards, J. B. and Sweep, F. C. and Gieger, C. and Corre, T. and Kajantie, E. and Thuesen, B. and Taes, Y. E. and Visser, W. E. and Hattersley, A. T. and Kratzsch, J. and Hamilton, A. and Li, W. and Homuth, G. and Lobina, M. and Mariotti, S. and Soranzo, N. and Cocca, M. and Nauck, M. and Spielhagen, C. and Ross, A. and Arnold, A. and van de Bunt, M. and Liyanarachchi, S. and Heier, M. and Grabe, H. J. and Masciullo, C. and Galesloot, T. E. and Lim, E. M. and Reischl, E. and Leedman, P. J. and Lai, S. and Delitala, A. and Bremner, A. P. and Philips, D. I. W. and Beilby, J. P. and Mulas, A. and Vocale, M. and Abecasis, G. and Forsen, T. and James, A. and Widen, E. and Hui, J. and Prokisch, H. and Rietzschel, E. E. and Palotie, A. and Feddema, P. and Fletcher, S. J. and Schramm, K. and Rotter, J. I. and Kluttig, A. and Radke, D. and Traglia, M. and Surdulescu, G. L. and He, H. and Franklyn, J. A. and Tiller, D. and Vaidya, B. and de Meyer, T. and Jørgensen, T. and Eriksson, J. G. and O’Leary, P. C. and Wichmann, E. and Hermus, A. R. and Psaty, B. M. and Ittermann, T. and Hofman, A. and Bosi, E. and Schlessinger, D. and Wallaschofski, H. and Pirastu, N. and Aulchenko, Y.S. and de la Chapelle, A. and Netea-Maier, R.T. and Gough, S.C.L. and Meyer zu Schwabedissen, H. and Frayling, T.M. and Kaufman, J.M. and Linneberg, A. and Raikkonen, K. and Smit, J.W.A. and Kiemeney, L.A. and Rivadeneira, F. and Uitterlinden, A.G. and Walsh, J.P. and Meisinger, C. and den Heijer, M. and Visser, T.J. and Spector, T.D. and Wilson, S.G. and Volzke, H. and Cappola, A. and Toniolo, D. and Sanna, S. and Naitza, S. and Peeters, R.P. (2014) Identification of novel genetic loci associated with thyroid peroxidase antibodies and clinical thyroid disease. PLoS Genetics, 10 (2). ISSN 15537390

Moore, Jason and McKnight, Amy Jayne and Döhler, Bernd and Simmonds, Matthew J. and Courtney, Aisling E. and Brand, Oliver J. and Briggs, David and Ball, Simon and Cockwell, Paul and Patterson, Christopher C. and Maxwell, Alexander P. and Gough, Stephen C. L. and Opelz, Gerhard and Borrows, Richard (2012) Donor ABCB1 variant associates with increased risk for kidney allograft failure. Journal of the American Society of Nephrology, 23 (11). pp. 1891-1899. ISSN 1046-6673

Simmonds, Matthew J. and Benavente, David and Brand, Oliver J. and Moore, Jason and Ball, Simon and Ferro, Charles J. and Briggs, David and Gough, Stephen C. L. and Borrows, Richard J. (2013) Skewing of female X-chromosome inactivation: an epigenetic risk factor for kidney transplantation outcome. Transplantation, 95 (5). e25-e28. ISSN 0041-1337

Zeitlin, A. and Simmonds, M. J. and Gough, S. C. (2008) Genetic developments in autoimmune thyroid disease: an evolutionary process. Clinical Endocrinology, 68 (5). pp. 671-682. ISSN 0300-0664

SH2B3 gene

Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN 1553-7390

SIAE gene

Hunt, K. A. and Smyth, D. J. and Balschun, T. and Ban, M. and Mistry, V. and Ahmed, T. and Barrett, J. C. and Bhaw-Rosun, L. and Bockett, N. A. and Brand, O. J. and Brouwer, E. and Concannon, P. and Cooper, J. D. and Dias, K-R. M. and van Diemen, C. C. and Dubois, P.C. and Edkins, S. and Fölster-Holst, R. and Fransen, K. and Glass, D. N. and Heap, G. A. R. and Hofmann, S. and Huizinga, T. W. J. and Hunt, S. and Langford, C. and Lee, J. and Mansfield, J. and Giovanna Marrosu, M. and Mathew, C. G. and Mein, C.A. and Müller-Quernheim, J. and Nutland, S. and Onengut-Gumuscu, S. and Ouwehand, W. and Pearce, K. and Prescott, N. and Posthumus, M. D. and Potter, S. and Rosati, G. and Sambrook, J. and Satsangi, J. and Schreiber, S. and Shtir, C. and Simmonds, M. J. and Sudman, M. and Thompson, S. D. and Toes, R. and Trynka, G. and Vyse, T. J. and Walker, N. M. and Weidinger, S. and Zhernakova, A. and Zoledziewska, M. and Weersma, R.K. and Gough, S.C.L. and Sawcer, S. and Wijmenga, C. and Parkes, M. and Cucca, F. and Franke, A. and Deloukas, P. and Rich, S. S. and Todd, J. A. and van Heel, D. A. (2011) Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry. Nature Genetics, 44 (1). pp. 3-5. ISSN 10614036

SRY gene

Elmrghni, Samir and Shaw, Michael and Ali, Nadir and Dixon, Ron and Ross Williams, D. (2012) Aberrations of human gender identification by amelogenin test in Libyans (Benghazi city). Indian Journal of Forensic Medicine and Toxicology, 6 (2). pp. 163-166. ISSN 0973-9122

STAT4 gene

Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN 1553-7390

SUMO protein

Simmonds, Matthew J. and Heward, J. M. and Carr-Smith, J. and Foxall, H. and Franklyn, J. A. and Gough, S. C. L. (2006) Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease. Journal of Clinical Endocrinology and Metabolism, 91 (3). pp. 1056-1061. ISSN 0021-972X

Sample Size, Europe

Hunt, K. A. and Mistry, V. and Bockett, N. A. and Ahmad, T. and Ban, M. and Barker, J. N. and Barrett, J. C. and Blackburn, H. and Brand, O. J. and Burren, O. and Capon, F. and Compston, A. and Gough, S. C. L. and Jostins, L. and Kong, Y. and Lee, J. C. and Lek, M. and MacArthur, D. G. and Mansfield, J. C. and Mathew, C. G. and Mein, C. A. and Mirza, M. and Nutland, S. and Onengut-Gumuscu, S. and Papouli, E. and Parkes, M. and Rich, S. S. and Sawcer, S. and Satsangi, J. and Simmonds, M. J. and Trembath, R. C. and Walker, N. M. and Wozniak, E. and Todd, J. A. and Simpson, M. A. and Plagnol, V. and van Heel, D. A. (2013) Negligible impact of rare autoimmune-locus coding-region variants on missing heritability. Nature, 498 (7453). pp. 232-235. ISSN 0028-0836

Sequence Analysis, DNA

Simmonds, M. J. and Heward, J.M. and Howson, J.M.M. and Foxall, H. and Nithiyananthan, R. and Franklyn, J.A. and Gough, S.C.L. (2004) A systematic approach to the assesment of known TNF-alpha polymorphisms in Graves' disease. Genes and Immunity, 5 (4). pp. 267-273. ISSN 1466-4879

Sex Distribution

Boelaert, Kristien and Newby, Paul R. and Simmonds, Matthew J. and Holder, Roger L. and Carr-Smith, Jacqueline D. and Heward, Joanne M. and Manji, Nilusha and Allahabadia, Amit and Armitage, Mary and Chatterjee, Krishna V. and Lazarus, John H. and Pearce, Simon H. and Vaidya, Bijay and Gough, Stephen C. and Franklyn, Jayne A. (2010) Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease. American Journal of Medicine, 123 (2). 183.e1-183.e9. ISSN 0002-9343

Stroke

Kilarski, Laura L. and Rutten-Jacobs, Loes C. A. and Bevan, Stephen and Baker, Rob and Hassan, Ahamad and Hughes, Derralynn A. and Markus, Hugh S. (2015) Prevalence of CADASIL and Fabry disease in a cohort of MRI defined younger onset lacunar stroke. PloS one, 10 (8). e0136352. ISSN 1932-6203

Traylor, Matthew and Bevan, Stephen and Baron, Jean-Claude and Hassan, Ahamad and Lewis, Cathryn M. and Markus, Hugh S. (2015) Genetic architecture of lacunar stroke. Stroke; a journal of cerebral circulation, 46 (9). pp. 2407-2412. ISSN 0039-2499

Susceptibility Loci

Hamilton, Alexander and Gough, Stephen C. L. and Simmonds, Matthew J. (2013) Genetics of Graves’ disease. In: eLS - Encyclopedia of Life Sciences. Wiley. ISBN 9780470015902

T lymphocyte

Simmonds, M. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. (2005) The CD40 Kozak SNP: a new susceptibility loci for Graves' disease? Clinical Endocrinology, 63 (2). pp. 232-233. ISSN 0300 0664

Simmonds, Matthew J. (2013) GWAS in autoimmune thyroid disease: redefining our understanding of pathogenesis. Nature Reviews Endocrinology, 9 (5). pp. 277-287. ISSN 1759-5029

T lymphocyte, Case-Control Studies

Simmonds, Matthew J. and Howson, Joanna M. M. and Heward, Joanne M. and Cordell, Heather J. and Foxall, Helen and Carr-Smith, Jackie and Gibson, Sarah M. and Walker, Neil and Tomer, Yaron and Franklyn, Jayne A. and Todd, John A. and Gough, Stephen C. L. (2005) Regression mapping of association between the human leukocyte antigen region and Graves' disease. American Journal of Human Genetics, 76 (1). pp. 157-163. ISSN 0002-9297

TEKT1 gene

Newby, Paul R. and Pickles, Oliver J. and Mazumdar, Samaresh and Brand, Oliver J. and Carr-Smith, Jacqueline D. and Pearce, Simon H. S. and Franklyn, Jayne A. and Evans, David M. and Simmonds, Matthew J. and Gough, Stephen C. L. and Welcome Trust Case-Control Consortium (WTCCC), . (2010) Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study. European Journal of Human Genetics, 18 (9). pp. 1021-1026. ISSN 1018-4813

TPO gene

Medici, M. and Porcu, E. and Pistis, G. and Teumer, A. and Brown, S. J. and Jensen, R. A. and Rawal, R. and Roef, G. L. and Plantinga, T. S. and Vermeulen, S. H. and Lahti, J. and Simmonds, M. J. and Husemoen, L. N. N. and Freathy, R. M. and Shields, B. M. and Pietzner, D. and Nagy, R. and Broer, L. and Chaker, L. and Korevaar, T. I. M. and Plia, M. G. and Sala, C. and Volker, U. and Richards, J. B. and Sweep, F. C. and Gieger, C. and Corre, T. and Kajantie, E. and Thuesen, B. and Taes, Y. E. and Visser, W. E. and Hattersley, A. T. and Kratzsch, J. and Hamilton, A. and Li, W. and Homuth, G. and Lobina, M. and Mariotti, S. and Soranzo, N. and Cocca, M. and Nauck, M. and Spielhagen, C. and Ross, A. and Arnold, A. and van de Bunt, M. and Liyanarachchi, S. and Heier, M. and Grabe, H. J. and Masciullo, C. and Galesloot, T. E. and Lim, E. M. and Reischl, E. and Leedman, P. J. and Lai, S. and Delitala, A. and Bremner, A. P. and Philips, D. I. W. and Beilby, J. P. and Mulas, A. and Vocale, M. and Abecasis, G. and Forsen, T. and James, A. and Widen, E. and Hui, J. and Prokisch, H. and Rietzschel, E. E. and Palotie, A. and Feddema, P. and Fletcher, S. J. and Schramm, K. and Rotter, J. I. and Kluttig, A. and Radke, D. and Traglia, M. and Surdulescu, G. L. and He, H. and Franklyn, J. A. and Tiller, D. and Vaidya, B. and de Meyer, T. and Jørgensen, T. and Eriksson, J. G. and O’Leary, P. C. and Wichmann, E. and Hermus, A. R. and Psaty, B. M. and Ittermann, T. and Hofman, A. and Bosi, E. and Schlessinger, D. and Wallaschofski, H. and Pirastu, N. and Aulchenko, Y.S. and de la Chapelle, A. and Netea-Maier, R.T. and Gough, S.C.L. and Meyer zu Schwabedissen, H. and Frayling, T.M. and Kaufman, J.M. and Linneberg, A. and Raikkonen, K. and Smit, J.W.A. and Kiemeney, L.A. and Rivadeneira, F. and Uitterlinden, A.G. and Walsh, J.P. and Meisinger, C. and den Heijer, M. and Visser, T.J. and Spector, T.D. and Wilson, S.G. and Volzke, H. and Cappola, A. and Toniolo, D. and Sanna, S. and Naitza, S. and Peeters, R.P. (2014) Identification of novel genetic loci associated with thyroid peroxidase antibodies and clinical thyroid disease. PLoS Genetics, 10 (2). ISSN 15537390

TSHR gene, Autoimmune Diseases

Zeitlin, A. and Simmonds, M. J. and Gough, S. C. (2008) Genetic developments in autoimmune thyroid disease: an evolutionary process. Clinical Endocrinology, 68 (5). pp. 671-682. ISSN 0300-0664

Taq polymerase

Zeitlin, A. A. and Heward, J. M. and Brand, O. J. and Newby, P. R. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2006) Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. Clinical Endocrinology, 65 (3). pp. 380-384. ISSN 0300-0664

Tg gene

Simmonds, M. J. and Gough, S. C. L. (2004) Unravelling the genetic complexity of autoimmune thyroid disease: HLA, CTLA-4 and beyond. Clinical and Experimental Immunology, 136 (1). pp. 1-10. ISSN 0009-9104

Thyroid

Hamilton, Alexander and Gough, Stephen C. L. and Simmonds, Matthew J. (2013) Genetics of Graves’ disease. In: eLS - Encyclopedia of Life Sciences. Wiley. ISBN 9780470015902

Thyroid Diseases

Cooper, J. D. and Simmonds, M. J. and Walker, N.M. and Burren, O. and Brand, O.J. and Guo, H. and Wallace, C. and Stevens, H. and Coleman, G and Franklyn, J.A. and Todd, J.A. and Gough, S.C.L. (2012) Seven newly identified loci for autoimmune thyroid disease. Human Molecular Genetics, 21 (23). pp. 5202-5208. ISSN 0964-6906

Simmonds, M. J. and Gough, S. C. L. (2004) Unravelling the genetic complexity of autoimmune thyroid disease: HLA, CTLA-4 and beyond. Clinical and Experimental Immunology, 136 (1). pp. 1-10. ISSN 0009-9104

Simmonds, Matthew J. and Gough, Stephen C. L. (2011) The search for the genetic contribution to autoimmune thyroid disease: The never ending story? Briefings in Functional Genomics, 10 (2). pp. 77-90. ISSN 2041-2649

Zeitlin, A. and Simmonds, M. J. and Gough, S. C. (2008) Genetic developments in autoimmune thyroid disease: an evolutionary process. Clinical Endocrinology, 68 (5). pp. 671-682. ISSN 0300-0664

Tissue Donors

Moore, J. and McKnight, A.J. and Simmonds, M. J. and Courtney, A. E. and Hanvesakul, R. and Brand, O. J. and Briggs, D. and Ball, S. and Cockwell, P. and Patterson, C.C. and Maxwell, A. P. and Gough, S. C. L. and Borrows, R. (2010) Association of caveolin-1 gene polymorphism with kidney transplant fibrosis and allograft failure. JAMA - Journal of the American Medical Association, 303 (13). pp. 1282-1287. ISSN 0098-7484

Moore, Jason and McKnight, Amy Jayne and Döhler, Bernd and Simmonds, Matthew J. and Courtney, Aisling E. and Brand, Oliver J. and Briggs, David and Ball, Simon and Cockwell, Paul and Patterson, Christopher C. and Maxwell, Alexander P. and Gough, Stephen C. L. and Opelz, Gerhard and Borrows, Richard (2012) Donor ABCB1 variant associates with increased risk for kidney allograft failure. Journal of the American Society of Nephrology, 23 (11). pp. 1891-1899. ISSN 1046-6673

Topoisomerase II

Nielsen, Christian F. and Huttner, Diana and Bizard, Anna H. and Hirano, Seiki and Li, Tian-Neng and Palmai-Pallag, Timea and Bjerregaard, Victoria A. and Liu, Ying and Nigg, Erich A. and Wang, Lily Hui-Ching and Hickson, Ian D. (2015) PICH promotes sister chromatid disjunction and co-operates with topoisomerase II in mitosis. Nature Communications, 6 . p. 8962. ISSN 2041-1723

Transcription Factors

Simmonds, Matthew and Gough, S. C. L. (2005) Genetic insights into disease mechanisms of autoimmunity. British Medical Bulletin, 71 (1). pp. 93-113. ISSN 0007-1420

Transplantation, Homologous

Moore, J. and McKnight, A.J. and Simmonds, M. J. and Courtney, A. E. and Hanvesakul, R. and Brand, O. J. and Briggs, D. and Ball, S. and Cockwell, P. and Patterson, C.C. and Maxwell, A. P. and Gough, S. C. L. and Borrows, R. (2010) Association of caveolin-1 gene polymorphism with kidney transplant fibrosis and allograft failure. JAMA - Journal of the American Medical Association, 303 (13). pp. 1282-1287. ISSN 0098-7484

Treatment Failure

Moore, J. and McKnight, A.J. and Simmonds, M. J. and Courtney, A. E. and Hanvesakul, R. and Brand, O. J. and Briggs, D. and Ball, S. and Cockwell, P. and Patterson, C.C. and Maxwell, A. P. and Gough, S. C. L. and Borrows, R. (2010) Association of caveolin-1 gene polymorphism with kidney transplant fibrosis and allograft failure. JAMA - Journal of the American Medical Association, 303 (13). pp. 1282-1287. ISSN 0098-7484

Trinucleotide Repeats

Simmonds, Matthew J. and Benavente, David and Brand, Oliver J. and Moore, Jason and Ball, Simon and Ferro, Charles J. and Briggs, David and Gough, Stephen C. L. and Borrows, Richard J. (2013) Skewing of female X-chromosome inactivation: an epigenetic risk factor for kidney transplantation outcome. Transplantation, 95 (5). e25-e28. ISSN 0041-1337

Tumor Necrosis Factor-alpha

Simmonds, M. J. and Heward, J.M. and Howson, J.M.M. and Foxall, H. and Nithiyananthan, R. and Franklyn, J.A. and Gough, S.C.L. (2004) A systematic approach to the assesment of known TNF-alpha polymorphisms in Graves' disease. Genes and Immunity, 5 (4). pp. 267-273. ISSN 1466-4879

UBASH3A gene

Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN 1553-7390

UFBs

Nielsen, Christian F. and Huttner, Diana and Bizard, Anna H. and Hirano, Seiki and Li, Tian-Neng and Palmai-Pallag, Timea and Bjerregaard, Victoria A. and Liu, Ying and Nigg, Erich A. and Wang, Lily Hui-Ching and Hickson, Ian D. (2015) PICH promotes sister chromatid disjunction and co-operates with topoisomerase II in mitosis. Nature Communications, 6 . p. 8962. ISSN 2041-1723

UNESCO

Langlois, Adele (2006) The governance of genomic information: will it come of age? Genomics, Society and Policy, 2 (3). pp. 49-63. ISSN UNSPECIFIED

UTX gene, Genome-Wide Association Study

Newby, Paul R. and Pickles, Oliver J. and Mazumdar, Samaresh and Brand, Oliver J. and Carr-Smith, Jacqueline D. and Pearce, Simon H. S. and Franklyn, Jayne A. and Evans, David M. and Simmonds, Matthew J. and Gough, Stephen C. L. and Welcome Trust Case-Control Consortium (WTCCC), . (2010) Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study. European Journal of Human Genetics, 18 (9). pp. 1021-1026. ISSN 1018-4813

United Kingdom

Ali, Nadir and Coulson-Thomas, Yvette M. and Norton, Andrew L. and Dixon, Ronald A. and Williams, D. Ross (2013) Announcement of population data: genetic data for 17 Y-STR AmpFℓSTR® Yfiler™ markers from an immigrant Pakistani population in the UK (British Pakistanis). Forensic Science International: Genetics, 7 (2). e40-e42. ISSN 1872-4973

Boelaert, Kristien and Newby, Paul R. and Simmonds, Matthew J. and Holder, Roger L. and Carr-Smith, Jacqueline D. and Heward, Joanne M. and Manji, Nilusha and Allahabadia, Amit and Armitage, Mary and Chatterjee, Krishna V. and Lazarus, John H. and Pearce, Simon H. and Vaidya, Bijay and Gough, Stephen C. and Franklyn, Jayne A. (2010) Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease. American Journal of Medicine, 123 (2). 183.e1-183.e9. ISSN 0002-9343

Chand, S. and Holle, J. U. and Hilhorst, M. and Simmonds, M. J. and Smith, S. and Kamesh, L. and Hewins, P. and McKnight, A. J. and Maxwell, A. P. and Willem Cohen Tervaert, J. and Wieczorek, S. and Harper, L. and Borrows, R. (2013) Caveolin-1 single nucleotide polymorphism in antineutrophil cytoplasmic antibody associated vasculitis. PLoS ONE, 8 (7). ISSN 1932-6203

Moore, J. and McKnight, A.J. and Simmonds, M. J. and Courtney, A. E. and Hanvesakul, R. and Brand, O. J. and Briggs, D. and Ball, S. and Cockwell, P. and Patterson, C.C. and Maxwell, A. P. and Gough, S. C. L. and Borrows, R. (2010) Association of caveolin-1 gene polymorphism with kidney transplant fibrosis and allograft failure. JAMA - Journal of the American Medical Association, 303 (13). pp. 1282-1287. ISSN 0098-7484

Simmonds, M. J. and Heward, J.M. and Howson, J.M.M. and Foxall, H. and Nithiyananthan, R. and Franklyn, J.A. and Gough, S.C.L. (2004) A systematic approach to the assesment of known TNF-alpha polymorphisms in Graves' disease. Genes and Immunity, 5 (4). pp. 267-273. ISSN 1466-4879

United Kingdom, Adaptor Proteins, Signal Transducing

Simmonds, Matthew J. and Heward, J. M. and Carr-Smith, J. and Foxall, H. and Franklyn, J. A. and Gough, S. C. L. (2006) Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease. Journal of Clinical Endocrinology and Metabolism, 91 (3). pp. 1056-1061. ISSN 0021-972X

United Kingdom, Adolescent

Zeitlin, A. A. and Heward, J. M. and Brand, O. J. and Newby, P. R. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2006) Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. Clinical Endocrinology, 65 (3). pp. 380-384. ISSN 0300-0664

United Kingdom, Adult

Moore, Jason and McKnight, Amy Jayne and Döhler, Bernd and Simmonds, Matthew J. and Courtney, Aisling E. and Brand, Oliver J. and Briggs, David and Ball, Simon and Cockwell, Paul and Patterson, Christopher C. and Maxwell, Alexander P. and Gough, Stephen C. L. and Opelz, Gerhard and Borrows, Richard (2012) Donor ABCB1 variant associates with increased risk for kidney allograft failure. Journal of the American Society of Nephrology, 23 (11). pp. 1891-1899. ISSN 1046-6673

United Kingdom, Alleles

Heward, J. M. and Simmonds, M. J. and Carr-Smith, J. and Foxall, H. and Franklyn, J. A. and Gough, S. C. L. (2004) A single nucleotide polymorphism in the CD40 gene on chromosome 20q (GD-2) provides no evidence for susceptibility to Graves' disease in UK Caucasians. Clinical Endocrinology, 61 (2). pp. 269-272. ISSN 0300-0664

United Kingdom, Autoantibodies

Simmonds, M. J. and Howson, J. M. M. and Heward, J. M. and Carr-Smith, J. and Franklyn, J. A. and Todd, J. A. and Gough, S. C. L. (2007) A novel and major association of HLA-C in Graves' disease that eclipses the classical HLA-DRB1 effect. Human Molecular Genetics, 16 (18). pp. 2149-2153. ISSN 0964-6906

Utopia

Hudson, John (2011) All watched over by machines of loving grace: part 3 "The monkey in the machine and the machine in the monkey". Digital Imaging and Photography . ISSN UNSPECIFIED

X chromosome

Elmrghni, Samir and Shaw, Michael and Ali, Nadir and Dixon, Ron and Ross Williams, D. (2012) Aberrations of human gender identification by amelogenin test in Libyans (Benghazi city). Indian Journal of Forensic Medicine and Toxicology, 6 (2). pp. 163-166. ISSN 0973-9122

X chromosome inactivation

Simmonds, Matthew J. and Benavente, David and Brand, Oliver J. and Moore, Jason and Ball, Simon and Ferro, Charles J. and Briggs, David and Gough, Stephen C. L. and Borrows, Richard J. (2013) Skewing of female X-chromosome inactivation: an epigenetic risk factor for kidney transplantation outcome. Transplantation, 95 (5). e25-e28. ISSN 0041-1337

acetylesterase

Hunt, K. A. and Smyth, D. J. and Balschun, T. and Ban, M. and Mistry, V. and Ahmed, T. and Barrett, J. C. and Bhaw-Rosun, L. and Bockett, N. A. and Brand, O. J. and Brouwer, E. and Concannon, P. and Cooper, J. D. and Dias, K-R. M. and van Diemen, C. C. and Dubois, P.C. and Edkins, S. and Fölster-Holst, R. and Fransen, K. and Glass, D. N. and Heap, G. A. R. and Hofmann, S. and Huizinga, T. W. J. and Hunt, S. and Langford, C. and Lee, J. and Mansfield, J. and Giovanna Marrosu, M. and Mathew, C. G. and Mein, C.A. and Müller-Quernheim, J. and Nutland, S. and Onengut-Gumuscu, S. and Ouwehand, W. and Pearce, K. and Prescott, N. and Posthumus, M. D. and Potter, S. and Rosati, G. and Sambrook, J. and Satsangi, J. and Schreiber, S. and Shtir, C. and Simmonds, M. J. and Sudman, M. and Thompson, S. D. and Toes, R. and Trynka, G. and Vyse, T. J. and Walker, N. M. and Weidinger, S. and Zhernakova, A. and Zoledziewska, M. and Weersma, R.K. and Gough, S.C.L. and Sawcer, S. and Wijmenga, C. and Parkes, M. and Cucca, F. and Franke, A. and Deloukas, P. and Rich, S. S. and Todd, J. A. and van Heel, D. A. (2011) Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry. Nature Genetics, 44 (1). pp. 3-5. ISSN 10614036

adult

Boelaert, Kristien and Newby, Paul R. and Simmonds, Matthew J. and Holder, Roger L. and Carr-Smith, Jacqueline D. and Heward, Joanne M. and Manji, Nilusha and Allahabadia, Amit and Armitage, Mary and Chatterjee, Krishna V. and Lazarus, John H. and Pearce, Simon H. and Vaidya, Bijay and Gough, Stephen C. and Franklyn, Jayne A. (2010) Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease. American Journal of Medicine, 123 (2). 183.e1-183.e9. ISSN 0002-9343

Moore, Jason and McKnight, Amy Jayne and Döhler, Bernd and Simmonds, Matthew J. and Courtney, Aisling E. and Brand, Oliver J. and Briggs, David and Ball, Simon and Cockwell, Paul and Patterson, Christopher C. and Maxwell, Alexander P. and Gough, Stephen C. L. and Opelz, Gerhard and Borrows, Richard (2012) Donor ABCB1 variant associates with increased risk for kidney allograft failure. Journal of the American Society of Nephrology, 23 (11). pp. 1891-1899. ISSN 1046-6673

Newby, P. R. and Roberts-Davies, E. L. and Brand, O. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2007) Tag SNP screening of the PDCD1 gene for association with Graves' disease. Clinical Endocrinology, 67 (1). pp. 125-128. ISSN 0300-0664

aged

Chand, S. and Chue, C. D. and Edwards, N. C. and Hodson, J. and Simmonds, M. J. and Hamilton, A. and Gough, S. C. L. and Harper, L. and Steeds, R. P. and Townend, J. N. and Ferro, C. J. and Borrows, R. (2015) Endothelial nitric oxide synthase single nucleotide polymorphism and left ventricular function in early chronic kidney disease. PLoS ONE, 10 (1). ISSN 1932-6203

Chand, S. and Holle, J. U. and Hilhorst, M. and Simmonds, M. J. and Smith, S. and Kamesh, L. and Hewins, P. and McKnight, A. J. and Maxwell, A. P. and Willem Cohen Tervaert, J. and Wieczorek, S. and Harper, L. and Borrows, R. (2013) Caveolin-1 single nucleotide polymorphism in antineutrophil cytoplasmic antibody associated vasculitis. PLoS ONE, 8 (7). ISSN 1932-6203

Medici, M. and Porcu, E. and Pistis, G. and Teumer, A. and Brown, S. J. and Jensen, R. A. and Rawal, R. and Roef, G. L. and Plantinga, T. S. and Vermeulen, S. H. and Lahti, J. and Simmonds, M. J. and Husemoen, L. N. N. and Freathy, R. M. and Shields, B. M. and Pietzner, D. and Nagy, R. and Broer, L. and Chaker, L. and Korevaar, T. I. M. and Plia, M. G. and Sala, C. and Volker, U. and Richards, J. B. and Sweep, F. C. and Gieger, C. and Corre, T. and Kajantie, E. and Thuesen, B. and Taes, Y. E. and Visser, W. E. and Hattersley, A. T. and Kratzsch, J. and Hamilton, A. and Li, W. and Homuth, G. and Lobina, M. and Mariotti, S. and Soranzo, N. and Cocca, M. and Nauck, M. and Spielhagen, C. and Ross, A. and Arnold, A. and van de Bunt, M. and Liyanarachchi, S. and Heier, M. and Grabe, H. J. and Masciullo, C. and Galesloot, T. E. and Lim, E. M. and Reischl, E. and Leedman, P. J. and Lai, S. and Delitala, A. and Bremner, A. P. and Philips, D. I. W. and Beilby, J. P. and Mulas, A. and Vocale, M. and Abecasis, G. and Forsen, T. and James, A. and Widen, E. and Hui, J. and Prokisch, H. and Rietzschel, E. E. and Palotie, A. and Feddema, P. and Fletcher, S. J. and Schramm, K. and Rotter, J. I. and Kluttig, A. and Radke, D. and Traglia, M. and Surdulescu, G. L. and He, H. and Franklyn, J. A. and Tiller, D. and Vaidya, B. and de Meyer, T. and Jørgensen, T. and Eriksson, J. G. and O’Leary, P. C. and Wichmann, E. and Hermus, A. R. and Psaty, B. M. and Ittermann, T. and Hofman, A. and Bosi, E. and Schlessinger, D. and Wallaschofski, H. and Pirastu, N. and Aulchenko, Y.S. and de la Chapelle, A. and Netea-Maier, R.T. and Gough, S.C.L. and Meyer zu Schwabedissen, H. and Frayling, T.M. and Kaufman, J.M. and Linneberg, A. and Raikkonen, K. and Smit, J.W.A. and Kiemeney, L.A. and Rivadeneira, F. and Uitterlinden, A.G. and Walsh, J.P. and Meisinger, C. and den Heijer, M. and Visser, T.J. and Spector, T.D. and Wilson, S.G. and Volzke, H. and Cappola, A. and Toniolo, D. and Sanna, S. and Naitza, S. and Peeters, R.P. (2014) Identification of novel genetic loci associated with thyroid peroxidase antibodies and clinical thyroid disease. PLoS Genetics, 10 (2). ISSN 15537390

alanine

Hafler, J. P. and Maier, L. M. and Cooper, J. D. and Plagnol, V. and Hinks, A. and Simmonds, M. J. and Stevens, H. and Walker, N. and Healy, B. and Howson, J. M. M. and Maisuria, M. and Duley, S. and Coleman, G. and Gough, S. C. L. and Worthington, J. and Kuchroo, V. K. and Wicker, L. S. and Todd, J. A. and IMSGC, . (2009) CD226 Gly307Ser association with multiple autoimmune diseases. Genes and Immunity, 10 (1). pp. 5-10. ISSN 1466-4879

allele

Hunt, K. A. and Mistry, V. and Bockett, N. A. and Ahmad, T. and Ban, M. and Barker, J. N. and Barrett, J. C. and Blackburn, H. and Brand, O. J. and Burren, O. and Capon, F. and Compston, A. and Gough, S. C. L. and Jostins, L. and Kong, Y. and Lee, J. C. and Lek, M. and MacArthur, D. G. and Mansfield, J. C. and Mathew, C. G. and Mein, C. A. and Mirza, M. and Nutland, S. and Onengut-Gumuscu, S. and Papouli, E. and Parkes, M. and Rich, S. S. and Sawcer, S. and Satsangi, J. and Simmonds, M. J. and Trembath, R. C. and Walker, N. M. and Wozniak, E. and Todd, J. A. and Simpson, M. A. and Plagnol, V. and van Heel, D. A. (2013) Negligible impact of rare autoimmune-locus coding-region variants on missing heritability. Nature, 498 (7453). pp. 232-235. ISSN 0028-0836

allotransplantation

Moore, J. and McKnight, A.J. and Simmonds, M. J. and Courtney, A. E. and Hanvesakul, R. and Brand, O. J. and Briggs, D. and Ball, S. and Cockwell, P. and Patterson, C.C. and Maxwell, A. P. and Gough, S. C. L. and Borrows, R. (2010) Association of caveolin-1 gene polymorphism with kidney transplant fibrosis and allograft failure. JAMA - Journal of the American Medical Association, 303 (13). pp. 1282-1287. ISSN 0098-7484

amelogenin

Elmrghni, Samir and Shaw, Michael and Ali, Nadir and Dixon, Ron and Ross Williams, D. (2012) Aberrations of human gender identification by amelogenin test in Libyans (Benghazi city). Indian Journal of Forensic Medicine and Toxicology, 6 (2). pp. 163-166. ISSN 0973-9122

analytic method

Newby, P. R. and Roberts-Davies, E. L. and Brand, O. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2007) Tag SNP screening of the PDCD1 gene for association with Graves' disease. Clinical Endocrinology, 67 (1). pp. 125-128. ISSN 0300-0664

anamnesis

Boelaert, Kristien and Newby, Paul R. and Simmonds, Matthew J. and Holder, Roger L. and Carr-Smith, Jacqueline D. and Heward, Joanne M. and Manji, Nilusha and Allahabadia, Amit and Armitage, Mary and Chatterjee, Krishna V. and Lazarus, John H. and Pearce, Simon H. and Vaidya, Bijay and Gough, Stephen C. and Franklyn, Jayne A. (2010) Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease. American Journal of Medicine, 123 (2). 183.e1-183.e9. ISSN 0002-9343

ankylosing spondylitis

Gough, S .C. L. and Simmonds, Matthew J. (2007) The HLA region and autoimmune disease: associations and mechanisms of action. Current Genomics, 8 (7). pp. 453-465. ISSN 1389-2029

antibody blood level

Medici, M. and Porcu, E. and Pistis, G. and Teumer, A. and Brown, S. J. and Jensen, R. A. and Rawal, R. and Roef, G. L. and Plantinga, T. S. and Vermeulen, S. H. and Lahti, J. and Simmonds, M. J. and Husemoen, L. N. N. and Freathy, R. M. and Shields, B. M. and Pietzner, D. and Nagy, R. and Broer, L. and Chaker, L. and Korevaar, T. I. M. and Plia, M. G. and Sala, C. and Volker, U. and Richards, J. B. and Sweep, F. C. and Gieger, C. and Corre, T. and Kajantie, E. and Thuesen, B. and Taes, Y. E. and Visser, W. E. and Hattersley, A. T. and Kratzsch, J. and Hamilton, A. and Li, W. and Homuth, G. and Lobina, M. and Mariotti, S. and Soranzo, N. and Cocca, M. and Nauck, M. and Spielhagen, C. and Ross, A. and Arnold, A. and van de Bunt, M. and Liyanarachchi, S. and Heier, M. and Grabe, H. J. and Masciullo, C. and Galesloot, T. E. and Lim, E. M. and Reischl, E. and Leedman, P. J. and Lai, S. and Delitala, A. and Bremner, A. P. and Philips, D. I. W. and Beilby, J. P. and Mulas, A. and Vocale, M. and Abecasis, G. and Forsen, T. and James, A. and Widen, E. and Hui, J. and Prokisch, H. and Rietzschel, E. E. and Palotie, A. and Feddema, P. and Fletcher, S. J. and Schramm, K. and Rotter, J. I. and Kluttig, A. and Radke, D. and Traglia, M. and Surdulescu, G. L. and He, H. and Franklyn, J. A. and Tiller, D. and Vaidya, B. and de Meyer, T. and Jørgensen, T. and Eriksson, J. G. and O’Leary, P. C. and Wichmann, E. and Hermus, A. R. and Psaty, B. M. and Ittermann, T. and Hofman, A. and Bosi, E. and Schlessinger, D. and Wallaschofski, H. and Pirastu, N. and Aulchenko, Y.S. and de la Chapelle, A. and Netea-Maier, R.T. and Gough, S.C.L. and Meyer zu Schwabedissen, H. and Frayling, T.M. and Kaufman, J.M. and Linneberg, A. and Raikkonen, K. and Smit, J.W.A. and Kiemeney, L.A. and Rivadeneira, F. and Uitterlinden, A.G. and Walsh, J.P. and Meisinger, C. and den Heijer, M. and Visser, T.J. and Spector, T.D. and Wilson, S.G. and Volzke, H. and Cappola, A. and Toniolo, D. and Sanna, S. and Naitza, S. and Peeters, R.P. (2014) Identification of novel genetic loci associated with thyroid peroxidase antibodies and clinical thyroid disease. PLoS Genetics, 10 (2). ISSN 15537390

antibody response

Simmonds, M. J. and Howson, J. M. M. and Heward, J. M. and Carr-Smith, J. and Franklyn, J. A. and Todd, J. A. and Gough, S. C. L. (2007) A novel and major association of HLA-C in Graves' disease that eclipses the classical HLA-DRB1 effect. Human Molecular Genetics, 16 (18). pp. 2149-2153. ISSN 0964-6906

antigen function

Zeitlin, A. A. and Heward, J. M. and Newby, P. R. and Carr-Smith, J. D. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2008) Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. Genes and Immunity, 9 (4). pp. 358-363. ISSN 1466-4879

antigen presentation

Gough, S .C. L. and Simmonds, Matthew J. (2007) The HLA region and autoimmune disease: associations and mechanisms of action. Current Genomics, 8 (7). pp. 453-465. ISSN 1389-2029

Simmonds, Matthew J. and Howson, Joanna M. M. and Heward, Joanne M. and Cordell, Heather J. and Foxall, Helen and Carr-Smith, Jackie and Gibson, Sarah M. and Walker, Neil and Tomer, Yaron and Franklyn, Jayne A. and Todd, John A. and Gough, Stephen C. L. (2005) Regression mapping of association between the human leukocyte antigen region and Graves' disease. American Journal of Human Genetics, 76 (1). pp. 157-163. ISSN 0002-9297

article

Boelaert, Kristien and Newby, Paul R. and Simmonds, Matthew J. and Holder, Roger L. and Carr-Smith, Jacqueline D. and Heward, Joanne M. and Manji, Nilusha and Allahabadia, Amit and Armitage, Mary and Chatterjee, Krishna V. and Lazarus, John H. and Pearce, Simon H. and Vaidya, Bijay and Gough, Stephen C. and Franklyn, Jayne A. (2010) Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease. American Journal of Medicine, 123 (2). 183.e1-183.e9. ISSN 0002-9343

Chand, S. and Holle, J. U. and Hilhorst, M. and Simmonds, M. J. and Smith, S. and Kamesh, L. and Hewins, P. and McKnight, A. J. and Maxwell, A. P. and Willem Cohen Tervaert, J. and Wieczorek, S. and Harper, L. and Borrows, R. (2013) Caveolin-1 single nucleotide polymorphism in antineutrophil cytoplasmic antibody associated vasculitis. PLoS ONE, 8 (7). ISSN 1932-6203

Cooper, J. D. and Simmonds, M. J. and Walker, N.M. and Burren, O. and Brand, O.J. and Guo, H. and Wallace, C. and Stevens, H. and Coleman, G and Franklyn, J.A. and Todd, J.A. and Gough, S.C.L. (2012) Seven newly identified loci for autoimmune thyroid disease. Human Molecular Genetics, 21 (23). pp. 5202-5208. ISSN 0964-6906

Hafler, J. P. and Maier, L. M. and Cooper, J. D. and Plagnol, V. and Hinks, A. and Simmonds, M. J. and Stevens, H. and Walker, N. and Healy, B. and Howson, J. M. M. and Maisuria, M. and Duley, S. and Coleman, G. and Gough, S. C. L. and Worthington, J. and Kuchroo, V. K. and Wicker, L. S. and Todd, J. A. and IMSGC, . (2009) CD226 Gly307Ser association with multiple autoimmune diseases. Genes and Immunity, 10 (1). pp. 5-10. ISSN 1466-4879

Hunt, K. A. and Mistry, V. and Bockett, N. A. and Ahmad, T. and Ban, M. and Barker, J. N. and Barrett, J. C. and Blackburn, H. and Brand, O. J. and Burren, O. and Capon, F. and Compston, A. and Gough, S. C. L. and Jostins, L. and Kong, Y. and Lee, J. C. and Lek, M. and MacArthur, D. G. and Mansfield, J. C. and Mathew, C. G. and Mein, C. A. and Mirza, M. and Nutland, S. and Onengut-Gumuscu, S. and Papouli, E. and Parkes, M. and Rich, S. S. and Sawcer, S. and Satsangi, J. and Simmonds, M. J. and Trembath, R. C. and Walker, N. M. and Wozniak, E. and Todd, J. A. and Simpson, M. A. and Plagnol, V. and van Heel, D. A. (2013) Negligible impact of rare autoimmune-locus coding-region variants on missing heritability. Nature, 498 (7453). pp. 232-235. ISSN 0028-0836

Medici, M. and Porcu, E. and Pistis, G. and Teumer, A. and Brown, S. J. and Jensen, R. A. and Rawal, R. and Roef, G. L. and Plantinga, T. S. and Vermeulen, S. H. and Lahti, J. and Simmonds, M. J. and Husemoen, L. N. N. and Freathy, R. M. and Shields, B. M. and Pietzner, D. and Nagy, R. and Broer, L. and Chaker, L. and Korevaar, T. I. M. and Plia, M. G. and Sala, C. and Volker, U. and Richards, J. B. and Sweep, F. C. and Gieger, C. and Corre, T. and Kajantie, E. and Thuesen, B. and Taes, Y. E. and Visser, W. E. and Hattersley, A. T. and Kratzsch, J. and Hamilton, A. and Li, W. and Homuth, G. and Lobina, M. and Mariotti, S. and Soranzo, N. and Cocca, M. and Nauck, M. and Spielhagen, C. and Ross, A. and Arnold, A. and van de Bunt, M. and Liyanarachchi, S. and Heier, M. and Grabe, H. J. and Masciullo, C. and Galesloot, T. E. and Lim, E. M. and Reischl, E. and Leedman, P. J. and Lai, S. and Delitala, A. and Bremner, A. P. and Philips, D. I. W. and Beilby, J. P. and Mulas, A. and Vocale, M. and Abecasis, G. and Forsen, T. and James, A. and Widen, E. and Hui, J. and Prokisch, H. and Rietzschel, E. E. and Palotie, A. and Feddema, P. and Fletcher, S. J. and Schramm, K. and Rotter, J. I. and Kluttig, A. and Radke, D. and Traglia, M. and Surdulescu, G. L. and He, H. and Franklyn, J. A. and Tiller, D. and Vaidya, B. and de Meyer, T. and Jørgensen, T. and Eriksson, J. G. and O’Leary, P. C. and Wichmann, E. and Hermus, A. R. and Psaty, B. M. and Ittermann, T. and Hofman, A. and Bosi, E. and Schlessinger, D. and Wallaschofski, H. and Pirastu, N. and Aulchenko, Y.S. and de la Chapelle, A. and Netea-Maier, R.T. and Gough, S.C.L. and Meyer zu Schwabedissen, H. and Frayling, T.M. and Kaufman, J.M. and Linneberg, A. and Raikkonen, K. and Smit, J.W.A. and Kiemeney, L.A. and Rivadeneira, F. and Uitterlinden, A.G. and Walsh, J.P. and Meisinger, C. and den Heijer, M. and Visser, T.J. and Spector, T.D. and Wilson, S.G. and Volzke, H. and Cappola, A. and Toniolo, D. and Sanna, S. and Naitza, S. and Peeters, R.P. (2014) Identification of novel genetic loci associated with thyroid peroxidase antibodies and clinical thyroid disease. PLoS Genetics, 10 (2). ISSN 15537390

Moore, J. and McKnight, A.J. and Simmonds, M. J. and Courtney, A. E. and Hanvesakul, R. and Brand, O. J. and Briggs, D. and Ball, S. and Cockwell, P. and Patterson, C.C. and Maxwell, A. P. and Gough, S. C. L. and Borrows, R. (2010) Association of caveolin-1 gene polymorphism with kidney transplant fibrosis and allograft failure. JAMA - Journal of the American Medical Association, 303 (13). pp. 1282-1287. ISSN 0098-7484

Moore, Jason and McKnight, Amy Jayne and Döhler, Bernd and Simmonds, Matthew J. and Courtney, Aisling E. and Brand, Oliver J. and Briggs, David and Ball, Simon and Cockwell, Paul and Patterson, Christopher C. and Maxwell, Alexander P. and Gough, Stephen C. L. and Opelz, Gerhard and Borrows, Richard (2012) Donor ABCB1 variant associates with increased risk for kidney allograft failure. Journal of the American Society of Nephrology, 23 (11). pp. 1891-1899. ISSN 1046-6673

Newby, P. R. and Roberts-Davies, E. L. and Brand, O. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2007) Tag SNP screening of the PDCD1 gene for association with Graves' disease. Clinical Endocrinology, 67 (1). pp. 125-128. ISSN 0300-0664

Newby, Paul R. and Pickles, Oliver J. and Mazumdar, Samaresh and Brand, Oliver J. and Carr-Smith, Jacqueline D. and Pearce, Simon H. S. and Franklyn, Jayne A. and Evans, David M. and Simmonds, Matthew J. and Gough, Stephen C. L. and Welcome Trust Case-Control Consortium (WTCCC), . (2010) Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study. European Journal of Human Genetics, 18 (9). pp. 1021-1026. ISSN 1018-4813

Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN 1553-7390

Simmonds, M. J. and Heward, J. M. and Barrett, J. C. and Franklyn, J. A. and Gough, S. C. L. (2006) Association of the BTNL2 rs2076530 single nucleotide polymorphism with Graves' disease appears to be secondary to DRB1 exon 2 position beta74. Clinical Endocrinology, 65 (4). pp. 429-432. ISSN 0300-0664

Simmonds, M. J. and Howson, J. M. M. and Heward, J. M. and Carr-Smith, J. and Franklyn, J. A. and Todd, J. A. and Gough, S. C. L. (2007) A novel and major association of HLA-C in Graves' disease that eclipses the classical HLA-DRB1 effect. Human Molecular Genetics, 16 (18). pp. 2149-2153. ISSN 0964-6906

Simmonds, Matthew J. and Howson, Joanna M. M. and Heward, Joanne M. and Cordell, Heather J. and Foxall, Helen and Carr-Smith, Jackie and Gibson, Sarah M. and Walker, Neil and Tomer, Yaron and Franklyn, Jayne A. and Todd, John A. and Gough, Stephen C. L. (2005) Regression mapping of association between the human leukocyte antigen region and Graves' disease. American Journal of Human Genetics, 76 (1). pp. 157-163. ISSN 0002-9297

Todd, J. A. and Walker, N. M. and Cooper, J. D. and Smyth, D. J. and Downes, K. and Plagnol, V. and Bailey, R. and Nejentsev, S. and Field, S. F. and Payne, F. and Lowe, C. E. and Szeszko, J. S. and Hafler, J. P. and Zeitels, L. and Yang, J. H. M. and Vella, A. and Nutland, S. and Stevens, H. E. and Schuilenburg, H. and Coleman, G. and Maisuria, M. and Meadows, W. and Smink, L. J. and Healy, B. and Burren, O. S. and Lam, A. A. C. and Ovington, N. R. and Allen, J. and Adlem, E. and Leung, H-T. and Wallace, C. and Howson, J. M. M. and Guja, C. and Ionescu-Tırgoviste, C. and Genetics of T1D in Finland, . and Simmonds, M. J. and Heward, J. M. and Gough, S. C. L. and WTCCC, . and Dunger, D. B. and Wicker, L. S. and Clayton, D. G. (2007) Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nature Genetics, 39 (7). pp. 857-864. ISSN 1061-4036

Yesmin, K. and Hargreaves, C. and Newby, P. R. and Brand, O. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2010) Association of FcGRIIa with Graves' disease: a potential role for dysregulated autoantibody clearance in disease onset/progression. Clinical Endocrinology, 73 (1). pp. 119-125. ISSN 0300-0664

Zeitlin, A. A. and Heward, J. M. and Newby, P. R. and Carr-Smith, J. D. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2008) Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. Genes and Immunity, 9 (4). pp. 358-363. ISSN 1466-4879

autoantibody

Medici, M. and Porcu, E. and Pistis, G. and Teumer, A. and Brown, S. J. and Jensen, R. A. and Rawal, R. and Roef, G. L. and Plantinga, T. S. and Vermeulen, S. H. and Lahti, J. and Simmonds, M. J. and Husemoen, L. N. N. and Freathy, R. M. and Shields, B. M. and Pietzner, D. and Nagy, R. and Broer, L. and Chaker, L. and Korevaar, T. I. M. and Plia, M. G. and Sala, C. and Volker, U. and Richards, J. B. and Sweep, F. C. and Gieger, C. and Corre, T. and Kajantie, E. and Thuesen, B. and Taes, Y. E. and Visser, W. E. and Hattersley, A. T. and Kratzsch, J. and Hamilton, A. and Li, W. and Homuth, G. and Lobina, M. and Mariotti, S. and Soranzo, N. and Cocca, M. and Nauck, M. and Spielhagen, C. and Ross, A. and Arnold, A. and van de Bunt, M. and Liyanarachchi, S. and Heier, M. and Grabe, H. J. and Masciullo, C. and Galesloot, T. E. and Lim, E. M. and Reischl, E. and Leedman, P. J. and Lai, S. and Delitala, A. and Bremner, A. P. and Philips, D. I. W. and Beilby, J. P. and Mulas, A. and Vocale, M. and Abecasis, G. and Forsen, T. and James, A. and Widen, E. and Hui, J. and Prokisch, H. and Rietzschel, E. E. and Palotie, A. and Feddema, P. and Fletcher, S. J. and Schramm, K. and Rotter, J. I. and Kluttig, A. and Radke, D. and Traglia, M. and Surdulescu, G. L. and He, H. and Franklyn, J. A. and Tiller, D. and Vaidya, B. and de Meyer, T. and Jørgensen, T. and Eriksson, J. G. and O’Leary, P. C. and Wichmann, E. and Hermus, A. R. and Psaty, B. M. and Ittermann, T. and Hofman, A. and Bosi, E. and Schlessinger, D. and Wallaschofski, H. and Pirastu, N. and Aulchenko, Y.S. and de la Chapelle, A. and Netea-Maier, R.T. and Gough, S.C.L. and Meyer zu Schwabedissen, H. and Frayling, T.M. and Kaufman, J.M. and Linneberg, A. and Raikkonen, K. and Smit, J.W.A. and Kiemeney, L.A. and Rivadeneira, F. and Uitterlinden, A.G. and Walsh, J.P. and Meisinger, C. and den Heijer, M. and Visser, T.J. and Spector, T.D. and Wilson, S.G. and Volzke, H. and Cappola, A. and Toniolo, D. and Sanna, S. and Naitza, S. and Peeters, R.P. (2014) Identification of novel genetic loci associated with thyroid peroxidase antibodies and clinical thyroid disease. PLoS Genetics, 10 (2). ISSN 15537390

Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN 1553-7390

Simmonds, M. J. and Howson, J. M. M. and Heward, J. M. and Carr-Smith, J. and Franklyn, J. A. and Todd, J. A. and Gough, S. C. L. (2007) A novel and major association of HLA-C in Graves' disease that eclipses the classical HLA-DRB1 effect. Human Molecular Genetics, 16 (18). pp. 2149-2153. ISSN 0964-6906

Yesmin, K. and Hargreaves, C. and Newby, P. R. and Brand, O. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2010) Association of FcGRIIa with Graves' disease: a potential role for dysregulated autoantibody clearance in disease onset/progression. Clinical Endocrinology, 73 (1). pp. 119-125. ISSN 0300-0664

autoimmune disease

Boelaert, Kristien and Newby, Paul R. and Simmonds, Matthew J. and Holder, Roger L. and Carr-Smith, Jacqueline D. and Heward, Joanne M. and Manji, Nilusha and Allahabadia, Amit and Armitage, Mary and Chatterjee, Krishna V. and Lazarus, John H. and Pearce, Simon H. and Vaidya, Bijay and Gough, Stephen C. and Franklyn, Jayne A. (2010) Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease. American Journal of Medicine, 123 (2). 183.e1-183.e9. ISSN 0002-9343

Cooper, J. D. and Simmonds, M. J. and Walker, N.M. and Burren, O. and Brand, O.J. and Guo, H. and Wallace, C. and Stevens, H. and Coleman, G and Franklyn, J.A. and Todd, J.A. and Gough, S.C.L. (2012) Seven newly identified loci for autoimmune thyroid disease. Human Molecular Genetics, 21 (23). pp. 5202-5208. ISSN 0964-6906

Gough, S .C. L. and Simmonds, Matthew J. (2007) The HLA region and autoimmune disease: associations and mechanisms of action. Current Genomics, 8 (7). pp. 453-465. ISSN 1389-2029

Hafler, J. P. and Maier, L. M. and Cooper, J. D. and Plagnol, V. and Hinks, A. and Simmonds, M. J. and Stevens, H. and Walker, N. and Healy, B. and Howson, J. M. M. and Maisuria, M. and Duley, S. and Coleman, G. and Gough, S. C. L. and Worthington, J. and Kuchroo, V. K. and Wicker, L. S. and Todd, J. A. and IMSGC, . (2009) CD226 Gly307Ser association with multiple autoimmune diseases. Genes and Immunity, 10 (1). pp. 5-10. ISSN 1466-4879

Hunt, K. A. and Mistry, V. and Bockett, N. A. and Ahmad, T. and Ban, M. and Barker, J. N. and Barrett, J. C. and Blackburn, H. and Brand, O. J. and Burren, O. and Capon, F. and Compston, A. and Gough, S. C. L. and Jostins, L. and Kong, Y. and Lee, J. C. and Lek, M. and MacArthur, D. G. and Mansfield, J. C. and Mathew, C. G. and Mein, C. A. and Mirza, M. and Nutland, S. and Onengut-Gumuscu, S. and Papouli, E. and Parkes, M. and Rich, S. S. and Sawcer, S. and Satsangi, J. and Simmonds, M. J. and Trembath, R. C. and Walker, N. M. and Wozniak, E. and Todd, J. A. and Simpson, M. A. and Plagnol, V. and van Heel, D. A. (2013) Negligible impact of rare autoimmune-locus coding-region variants on missing heritability. Nature, 498 (7453). pp. 232-235. ISSN 0028-0836

Medici, M. and Porcu, E. and Pistis, G. and Teumer, A. and Brown, S. J. and Jensen, R. A. and Rawal, R. and Roef, G. L. and Plantinga, T. S. and Vermeulen, S. H. and Lahti, J. and Simmonds, M. J. and Husemoen, L. N. N. and Freathy, R. M. and Shields, B. M. and Pietzner, D. and Nagy, R. and Broer, L. and Chaker, L. and Korevaar, T. I. M. and Plia, M. G. and Sala, C. and Volker, U. and Richards, J. B. and Sweep, F. C. and Gieger, C. and Corre, T. and Kajantie, E. and Thuesen, B. and Taes, Y. E. and Visser, W. E. and Hattersley, A. T. and Kratzsch, J. and Hamilton, A. and Li, W. and Homuth, G. and Lobina, M. and Mariotti, S. and Soranzo, N. and Cocca, M. and Nauck, M. and Spielhagen, C. and Ross, A. and Arnold, A. and van de Bunt, M. and Liyanarachchi, S. and Heier, M. and Grabe, H. J. and Masciullo, C. and Galesloot, T. E. and Lim, E. M. and Reischl, E. and Leedman, P. J. and Lai, S. and Delitala, A. and Bremner, A. P. and Philips, D. I. W. and Beilby, J. P. and Mulas, A. and Vocale, M. and Abecasis, G. and Forsen, T. and James, A. and Widen, E. and Hui, J. and Prokisch, H. and Rietzschel, E. E. and Palotie, A. and Feddema, P. and Fletcher, S. J. and Schramm, K. and Rotter, J. I. and Kluttig, A. and Radke, D. and Traglia, M. and Surdulescu, G. L. and He, H. and Franklyn, J. A. and Tiller, D. and Vaidya, B. and de Meyer, T. and Jørgensen, T. and Eriksson, J. G. and O’Leary, P. C. and Wichmann, E. and Hermus, A. R. and Psaty, B. M. and Ittermann, T. and Hofman, A. and Bosi, E. and Schlessinger, D. and Wallaschofski, H. and Pirastu, N. and Aulchenko, Y.S. and de la Chapelle, A. and Netea-Maier, R.T. and Gough, S.C.L. and Meyer zu Schwabedissen, H. and Frayling, T.M. and Kaufman, J.M. and Linneberg, A. and Raikkonen, K. and Smit, J.W.A. and Kiemeney, L.A. and Rivadeneira, F. and Uitterlinden, A.G. and Walsh, J.P. and Meisinger, C. and den Heijer, M. and Visser, T.J. and Spector, T.D. and Wilson, S.G. and Volzke, H. and Cappola, A. and Toniolo, D. and Sanna, S. and Naitza, S. and Peeters, R.P. (2014) Identification of novel genetic loci associated with thyroid peroxidase antibodies and clinical thyroid disease. PLoS Genetics, 10 (2). ISSN 15537390

Simmonds, M. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. (2005) The CD40 Kozak SNP: a new susceptibility loci for Graves' disease? Clinical Endocrinology, 63 (2). pp. 232-233. ISSN 0300 0664

Simmonds, Matthew J. and Heward, J. M. and Carr-Smith, J. and Foxall, H. and Franklyn, J. A. and Gough, S. C. L. (2006) Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease. Journal of Clinical Endocrinology and Metabolism, 91 (3). pp. 1056-1061. ISSN 0021-972X

Zeitlin, A. A. and Heward, J. M. and Brand, O. J. and Newby, P. R. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2006) Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. Clinical Endocrinology, 65 (3). pp. 380-384. ISSN 0300-0664

autoimmune polyendocrinopathy candidiasis ectodermal dystrophy

Simmonds, Matthew and Gough, S. C. L. (2005) Genetic insights into disease mechanisms of autoimmunity. British Medical Bulletin, 71 (1). pp. 93-113. ISSN 0007-1420

autoimmune regulator protein

Simmonds, Matthew and Gough, S. C. L. (2005) Genetic insights into disease mechanisms of autoimmunity. British Medical Bulletin, 71 (1). pp. 93-113. ISSN 0007-1420

autoimmune regulator protein 1

Simmonds, Matthew and Gough, S. C. L. (2005) Genetic insights into disease mechanisms of autoimmunity. British Medical Bulletin, 71 (1). pp. 93-113. ISSN 0007-1420

autoimmune thyroid disease

Medici, M. and Porcu, E. and Pistis, G. and Teumer, A. and Brown, S. J. and Jensen, R. A. and Rawal, R. and Roef, G. L. and Plantinga, T. S. and Vermeulen, S. H. and Lahti, J. and Simmonds, M. J. and Husemoen, L. N. N. and Freathy, R. M. and Shields, B. M. and Pietzner, D. and Nagy, R. and Broer, L. and Chaker, L. and Korevaar, T. I. M. and Plia, M. G. and Sala, C. and Volker, U. and Richards, J. B. and Sweep, F. C. and Gieger, C. and Corre, T. and Kajantie, E. and Thuesen, B. and Taes, Y. E. and Visser, W. E. and Hattersley, A. T. and Kratzsch, J. and Hamilton, A. and Li, W. and Homuth, G. and Lobina, M. and Mariotti, S. and Soranzo, N. and Cocca, M. and Nauck, M. and Spielhagen, C. and Ross, A. and Arnold, A. and van de Bunt, M. and Liyanarachchi, S. and Heier, M. and Grabe, H. J. and Masciullo, C. and Galesloot, T. E. and Lim, E. M. and Reischl, E. and Leedman, P. J. and Lai, S. and Delitala, A. and Bremner, A. P. and Philips, D. I. W. and Beilby, J. P. and Mulas, A. and Vocale, M. and Abecasis, G. and Forsen, T. and James, A. and Widen, E. and Hui, J. and Prokisch, H. and Rietzschel, E. E. and Palotie, A. and Feddema, P. and Fletcher, S. J. and Schramm, K. and Rotter, J. I. and Kluttig, A. and Radke, D. and Traglia, M. and Surdulescu, G. L. and He, H. and Franklyn, J. A. and Tiller, D. and Vaidya, B. and de Meyer, T. and Jørgensen, T. and Eriksson, J. G. and O’Leary, P. C. and Wichmann, E. and Hermus, A. R. and Psaty, B. M. and Ittermann, T. and Hofman, A. and Bosi, E. and Schlessinger, D. and Wallaschofski, H. and Pirastu, N. and Aulchenko, Y.S. and de la Chapelle, A. and Netea-Maier, R.T. and Gough, S.C.L. and Meyer zu Schwabedissen, H. and Frayling, T.M. and Kaufman, J.M. and Linneberg, A. and Raikkonen, K. and Smit, J.W.A. and Kiemeney, L.A. and Rivadeneira, F. and Uitterlinden, A.G. and Walsh, J.P. and Meisinger, C. and den Heijer, M. and Visser, T.J. and Spector, T.D. and Wilson, S.G. and Volzke, H. and Cappola, A. and Toniolo, D. and Sanna, S. and Naitza, S. and Peeters, R.P. (2014) Identification of novel genetic loci associated with thyroid peroxidase antibodies and clinical thyroid disease. PLoS Genetics, 10 (2). ISSN 15537390

Simmonds, Matthew J. (2013) GWAS in autoimmune thyroid disease: redefining our understanding of pathogenesis. Nature Reviews Endocrinology, 9 (5). pp. 277-287. ISSN 1759-5029

autoimmune thyroiditis

Boelaert, Kristien and Newby, Paul R. and Simmonds, Matthew J. and Holder, Roger L. and Carr-Smith, Jacqueline D. and Heward, Joanne M. and Manji, Nilusha and Allahabadia, Amit and Armitage, Mary and Chatterjee, Krishna V. and Lazarus, John H. and Pearce, Simon H. and Vaidya, Bijay and Gough, Stephen C. and Franklyn, Jayne A. (2010) Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease. American Journal of Medicine, 123 (2). 183.e1-183.e9. ISSN 0002-9343

Simmonds, Matthew J. and Gough, Stephen C. L. (2011) The search for the genetic contribution to autoimmune thyroid disease: The never ending story? Briefings in Functional Genomics, 10 (2). pp. 77-90. ISSN 2041-2649

autoimmunity

Hunt, K. A. and Mistry, V. and Bockett, N. A. and Ahmad, T. and Ban, M. and Barker, J. N. and Barrett, J. C. and Blackburn, H. and Brand, O. J. and Burren, O. and Capon, F. and Compston, A. and Gough, S. C. L. and Jostins, L. and Kong, Y. and Lee, J. C. and Lek, M. and MacArthur, D. G. and Mansfield, J. C. and Mathew, C. G. and Mein, C. A. and Mirza, M. and Nutland, S. and Onengut-Gumuscu, S. and Papouli, E. and Parkes, M. and Rich, S. S. and Sawcer, S. and Satsangi, J. and Simmonds, M. J. and Trembath, R. C. and Walker, N. M. and Wozniak, E. and Todd, J. A. and Simpson, M. A. and Plagnol, V. and van Heel, D. A. (2013) Negligible impact of rare autoimmune-locus coding-region variants on missing heritability. Nature, 498 (7453). pp. 232-235. ISSN 0028-0836

Medici, M. and Porcu, E. and Pistis, G. and Teumer, A. and Brown, S. J. and Jensen, R. A. and Rawal, R. and Roef, G. L. and Plantinga, T. S. and Vermeulen, S. H. and Lahti, J. and Simmonds, M. J. and Husemoen, L. N. N. and Freathy, R. M. and Shields, B. M. and Pietzner, D. and Nagy, R. and Broer, L. and Chaker, L. and Korevaar, T. I. M. and Plia, M. G. and Sala, C. and Volker, U. and Richards, J. B. and Sweep, F. C. and Gieger, C. and Corre, T. and Kajantie, E. and Thuesen, B. and Taes, Y. E. and Visser, W. E. and Hattersley, A. T. and Kratzsch, J. and Hamilton, A. and Li, W. and Homuth, G. and Lobina, M. and Mariotti, S. and Soranzo, N. and Cocca, M. and Nauck, M. and Spielhagen, C. and Ross, A. and Arnold, A. and van de Bunt, M. and Liyanarachchi, S. and Heier, M. and Grabe, H. J. and Masciullo, C. and Galesloot, T. E. and Lim, E. M. and Reischl, E. and Leedman, P. J. and Lai, S. and Delitala, A. and Bremner, A. P. and Philips, D. I. W. and Beilby, J. P. and Mulas, A. and Vocale, M. and Abecasis, G. and Forsen, T. and James, A. and Widen, E. and Hui, J. and Prokisch, H. and Rietzschel, E. E. and Palotie, A. and Feddema, P. and Fletcher, S. J. and Schramm, K. and Rotter, J. I. and Kluttig, A. and Radke, D. and Traglia, M. and Surdulescu, G. L. and He, H. and Franklyn, J. A. and Tiller, D. and Vaidya, B. and de Meyer, T. and Jørgensen, T. and Eriksson, J. G. and O’Leary, P. C. and Wichmann, E. and Hermus, A. R. and Psaty, B. M. and Ittermann, T. and Hofman, A. and Bosi, E. and Schlessinger, D. and Wallaschofski, H. and Pirastu, N. and Aulchenko, Y.S. and de la Chapelle, A. and Netea-Maier, R.T. and Gough, S.C.L. and Meyer zu Schwabedissen, H. and Frayling, T.M. and Kaufman, J.M. and Linneberg, A. and Raikkonen, K. and Smit, J.W.A. and Kiemeney, L.A. and Rivadeneira, F. and Uitterlinden, A.G. and Walsh, J.P. and Meisinger, C. and den Heijer, M. and Visser, T.J. and Spector, T.D. and Wilson, S.G. and Volzke, H. and Cappola, A. and Toniolo, D. and Sanna, S. and Naitza, S. and Peeters, R.P. (2014) Identification of novel genetic loci associated with thyroid peroxidase antibodies and clinical thyroid disease. PLoS Genetics, 10 (2). ISSN 15537390

Simmonds, Matthew and Gough, S. C. L. (2005) Genetic insights into disease mechanisms of autoimmunity. British Medical Bulletin, 71 (1). pp. 93-113. ISSN 0007-1420

Simmonds, Matthew J. and Brand, Oliver J. and Barrett, Jeffrey C. and Newby, Paul R. and Franklyn, Jayne A. and Gough, Stephen C. L. (2010) Association of Fc receptor-like 5 (FCRL5) with Graves' disease is secondary to the effect of FCRL3. Clinical Endocrinology, 73 (5). pp. 654-660. ISSN 0300-0664

azathioprine

Simmonds, Matthew J. and Benavente, David and Brand, Oliver J. and Moore, Jason and Ball, Simon and Ferro, Charles J. and Briggs, David and Gough, Stephen C. L. and Borrows, Richard J. (2013) Skewing of female X-chromosome inactivation: an epigenetic risk factor for kidney transplantation outcome. Transplantation, 95 (5). e25-e28. ISSN 0041-1337

bacterial infection

Gough, S .C. L. and Simmonds, Matthew J. (2007) The HLA region and autoimmune disease: associations and mechanisms of action. Current Genomics, 8 (7). pp. 453-465. ISSN 1389-2029

binding site

Simmonds, Matthew J. and Howson, Joanna M. M. and Heward, Joanne M. and Cordell, Heather J. and Foxall, Helen and Carr-Smith, Jackie and Gibson, Sarah M. and Walker, Neil and Tomer, Yaron and Franklyn, Jayne A. and Todd, John A. and Gough, Stephen C. L. (2005) Regression mapping of association between the human leukocyte antigen region and Graves' disease. American Journal of Human Genetics, 76 (1). pp. 157-163. ISSN 0002-9297

biogenetics

Davy, Zowie (2012) Differences in sexual development: towards a phenomenological understanding of gender variance. In: Controversies and Confrontations: Violence and Agency, 6-7 December 2012, University of Vienna, Austria.

blood group ABO system

Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN 1553-7390

bmjgoldcheck

Southgate, Laura and Sukalo, Maja and Karountzos, Anastasios S. V. and Taylor, Edward J. and Collinson, Claire S. and Ruddy, Deborah and Snape, Katie M. and Dallapiccola, Bruno and Tolmie, John L. and Joss, Shelagh and Brancati, Francesco and Digilio, M. Cristina and Graul-Neumann, Luitgard M. and Salviati, Leonardo and Coerdt, Wiltrud and Jacquemin, Emmanuel and Wuyts, Wim and Zenker, Martin and Machado, Rajiv D. and Trembath, Richard C. (2015) Haploinsufficiency of the NOTCH1 receptor as a cause of Adams-Oliver Syndrome with variable cardiac anomalies. Circulation: Cardiovascular genetics, 8 (4). ISSN 1942-325X

body mass

Chand, S. and Chue, C. D. and Edwards, N. C. and Hodson, J. and Simmonds, M. J. and Hamilton, A. and Gough, S. C. L. and Harper, L. and Steeds, R. P. and Townend, J. N. and Ferro, C. J. and Borrows, R. (2015) Endothelial nitric oxide synthase single nucleotide polymorphism and left ventricular function in early chronic kidney disease. PLoS ONE, 10 (1). ISSN 1932-6203

cadaver kidney

Simmonds, Matthew J. and Benavente, David and Brand, Oliver J. and Moore, Jason and Ball, Simon and Ferro, Charles J. and Briggs, David and Gough, Stephen C. L. and Borrows, Richard J. (2013) Skewing of female X-chromosome inactivation: an epigenetic risk factor for kidney transplantation outcome. Transplantation, 95 (5). e25-e28. ISSN 0041-1337

cancer risk

Medici, M. and Porcu, E. and Pistis, G. and Teumer, A. and Brown, S. J. and Jensen, R. A. and Rawal, R. and Roef, G. L. and Plantinga, T. S. and Vermeulen, S. H. and Lahti, J. and Simmonds, M. J. and Husemoen, L. N. N. and Freathy, R. M. and Shields, B. M. and Pietzner, D. and Nagy, R. and Broer, L. and Chaker, L. and Korevaar, T. I. M. and Plia, M. G. and Sala, C. and Volker, U. and Richards, J. B. and Sweep, F. C. and Gieger, C. and Corre, T. and Kajantie, E. and Thuesen, B. and Taes, Y. E. and Visser, W. E. and Hattersley, A. T. and Kratzsch, J. and Hamilton, A. and Li, W. and Homuth, G. and Lobina, M. and Mariotti, S. and Soranzo, N. and Cocca, M. and Nauck, M. and Spielhagen, C. and Ross, A. and Arnold, A. and van de Bunt, M. and Liyanarachchi, S. and Heier, M. and Grabe, H. J. and Masciullo, C. and Galesloot, T. E. and Lim, E. M. and Reischl, E. and Leedman, P. J. and Lai, S. and Delitala, A. and Bremner, A. P. and Philips, D. I. W. and Beilby, J. P. and Mulas, A. and Vocale, M. and Abecasis, G. and Forsen, T. and James, A. and Widen, E. and Hui, J. and Prokisch, H. and Rietzschel, E. E. and Palotie, A. and Feddema, P. and Fletcher, S. J. and Schramm, K. and Rotter, J. I. and Kluttig, A. and Radke, D. and Traglia, M. and Surdulescu, G. L. and He, H. and Franklyn, J. A. and Tiller, D. and Vaidya, B. and de Meyer, T. and Jørgensen, T. and Eriksson, J. G. and O’Leary, P. C. and Wichmann, E. and Hermus, A. R. and Psaty, B. M. and Ittermann, T. and Hofman, A. and Bosi, E. and Schlessinger, D. and Wallaschofski, H. and Pirastu, N. and Aulchenko, Y.S. and de la Chapelle, A. and Netea-Maier, R.T. and Gough, S.C.L. and Meyer zu Schwabedissen, H. and Frayling, T.M. and Kaufman, J.M. and Linneberg, A. and Raikkonen, K. and Smit, J.W.A. and Kiemeney, L.A. and Rivadeneira, F. and Uitterlinden, A.G. and Walsh, J.P. and Meisinger, C. and den Heijer, M. and Visser, T.J. and Spector, T.D. and Wilson, S.G. and Volzke, H. and Cappola, A. and Toniolo, D. and Sanna, S. and Naitza, S. and Peeters, R.P. (2014) Identification of novel genetic loci associated with thyroid peroxidase antibodies and clinical thyroid disease. PLoS Genetics, 10 (2). ISSN 15537390

cardiovascular magnetic resonance

Chand, S. and Chue, C. D. and Edwards, N. C. and Hodson, J. and Simmonds, M. J. and Hamilton, A. and Gough, S. C. L. and Harper, L. and Steeds, R. P. and Townend, J. N. and Ferro, C. J. and Borrows, R. (2015) Endothelial nitric oxide synthase single nucleotide polymorphism and left ventricular function in early chronic kidney disease. PLoS ONE, 10 (1). ISSN 1932-6203

case control study

Heward, J. M. and Simmonds, M. J. and Carr-Smith, J. and Foxall, H. and Franklyn, J. A. and Gough, S. C. L. (2004) A single nucleotide polymorphism in the CD40 gene on chromosome 20q (GD-2) provides no evidence for susceptibility to Graves' disease in UK Caucasians. Clinical Endocrinology, 61 (2). pp. 269-272. ISSN 0300-0664

Newby, P. R. and Roberts-Davies, E. L. and Brand, O. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2007) Tag SNP screening of the PDCD1 gene for association with Graves' disease. Clinical Endocrinology, 67 (1). pp. 125-128. ISSN 0300-0664

Newby, Paul R. and Pickles, Oliver J. and Mazumdar, Samaresh and Brand, Oliver J. and Carr-Smith, Jacqueline D. and Pearce, Simon H. S. and Franklyn, Jayne A. and Evans, David M. and Simmonds, Matthew J. and Gough, Stephen C. L. and Welcome Trust Case-Control Consortium (WTCCC), . (2010) Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study. European Journal of Human Genetics, 18 (9). pp. 1021-1026. ISSN 1018-4813

Simmonds, M. J. and Heward, J.M. and Howson, J.M.M. and Foxall, H. and Nithiyananthan, R. and Franklyn, J.A. and Gough, S.C.L. (2004) A systematic approach to the assesment of known TNF-alpha polymorphisms in Graves' disease. Genes and Immunity, 5 (4). pp. 267-273. ISSN 1466-4879

Simmonds, Matthew J. and Brand, Oliver J. and Barrett, Jeffrey C. and Newby, Paul R. and Franklyn, Jayne A. and Gough, Stephen C. L. (2010) Association of Fc receptor-like 5 (FCRL5) with Graves' disease is secondary to the effect of FCRL3. Clinical Endocrinology, 73 (5). pp. 654-660. ISSN 0300-0664

Simmonds, Matthew J. and Howson, Joanna M. M. and Heward, Joanne M. and Cordell, Heather J. and Foxall, Helen and Carr-Smith, Jackie and Gibson, Sarah M. and Walker, Neil and Tomer, Yaron and Franklyn, Jayne A. and Todd, John A. and Gough, Stephen C. L. (2005) Regression mapping of association between the human leukocyte antigen region and Graves' disease. American Journal of Human Genetics, 76 (1). pp. 157-163. ISSN 0002-9297

Yesmin, K. and Hargreaves, C. and Newby, P. R. and Brand, O. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2010) Association of FcGRIIa with Graves' disease: a potential role for dysregulated autoantibody clearance in disease onset/progression. Clinical Endocrinology, 73 (1). pp. 119-125. ISSN 0300-0664

Zeitlin, A. A. and Heward, J. M. and Brand, O. J. and Newby, P. R. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2006) Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. Clinical Endocrinology, 65 (3). pp. 380-384. ISSN 0300-0664

Zeitlin, A. A. and Heward, J. M. and Newby, P. R. and Carr-Smith, J. D. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2008) Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. Genes and Immunity, 9 (4). pp. 358-363. ISSN 1466-4879

caveolin 1

Chand, S. and Holle, J. U. and Hilhorst, M. and Simmonds, M. J. and Smith, S. and Kamesh, L. and Hewins, P. and McKnight, A. J. and Maxwell, A. P. and Willem Cohen Tervaert, J. and Wieczorek, S. and Harper, L. and Borrows, R. (2013) Caveolin-1 single nucleotide polymorphism in antineutrophil cytoplasmic antibody associated vasculitis. PLoS ONE, 8 (7). ISSN 1932-6203

Moore, J. and McKnight, A.J. and Simmonds, M. J. and Courtney, A. E. and Hanvesakul, R. and Brand, O. J. and Briggs, D. and Ball, S. and Cockwell, P. and Patterson, C.C. and Maxwell, A. P. and Gough, S. C. L. and Borrows, R. (2010) Association of caveolin-1 gene polymorphism with kidney transplant fibrosis and allograft failure. JAMA - Journal of the American Medical Association, 303 (13). pp. 1282-1287. ISSN 0098-7484

caveolin 1, adult

Moore, J. and McKnight, A.J. and Simmonds, M. J. and Courtney, A. E. and Hanvesakul, R. and Brand, O. J. and Briggs, D. and Ball, S. and Cockwell, P. and Patterson, C.C. and Maxwell, A. P. and Gough, S. C. L. and Borrows, R. (2010) Association of caveolin-1 gene polymorphism with kidney transplant fibrosis and allograft failure. JAMA - Journal of the American Medical Association, 303 (13). pp. 1282-1287. ISSN 0098-7484

celiac disease

Boelaert, Kristien and Newby, Paul R. and Simmonds, Matthew J. and Holder, Roger L. and Carr-Smith, Jacqueline D. and Heward, Joanne M. and Manji, Nilusha and Allahabadia, Amit and Armitage, Mary and Chatterjee, Krishna V. and Lazarus, John H. and Pearce, Simon H. and Vaidya, Bijay and Gough, Stephen C. and Franklyn, Jayne A. (2010) Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease. American Journal of Medicine, 123 (2). 183.e1-183.e9. ISSN 0002-9343

Gough, S .C. L. and Simmonds, Matthew J. (2007) The HLA region and autoimmune disease: associations and mechanisms of action. Current Genomics, 8 (7). pp. 453-465. ISSN 1389-2029

cell antigen

Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN 1553-7390

cell line

Simmonds, M. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. (2005) The CD40 Kozak SNP: a new susceptibility loci for Graves' disease? Clinical Endocrinology, 63 (2). pp. 232-233. ISSN 0300 0664

cell surface

Simmonds, M. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. (2005) The CD40 Kozak SNP: a new susceptibility loci for Graves' disease? Clinical Endocrinology, 63 (2). pp. 232-233. ISSN 0300 0664

cellular senescence

Xing, Meichun and Wang, Xiaohui and Palmai-Pallag, Timea and Shen, Huahao and Helleday, Thomas and Hickson, Ian D. and Ying, Songmin (2015) Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response. Oncotarget, 6 (35). pp. 37638-37646. ISSN 1949-2553

child

Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN 1553-7390

cholesterol

Chand, S. and Chue, C. D. and Edwards, N. C. and Hodson, J. and Simmonds, M. J. and Hamilton, A. and Gough, S. C. L. and Harper, L. and Steeds, R. P. and Townend, J. N. and Ferro, C. J. and Borrows, R. (2015) Endothelial nitric oxide synthase single nucleotide polymorphism and left ventricular function in early chronic kidney disease. PLoS ONE, 10 (1). ISSN 1932-6203

cholesterol blood level

Chand, S. and Chue, C. D. and Edwards, N. C. and Hodson, J. and Simmonds, M. J. and Hamilton, A. and Gough, S. C. L. and Harper, L. and Steeds, R. P. and Townend, J. N. and Ferro, C. J. and Borrows, R. (2015) Endothelial nitric oxide synthase single nucleotide polymorphism and left ventricular function in early chronic kidney disease. PLoS ONE, 10 (1). ISSN 1932-6203

chromatin remodeling

Herr, Patrick and Lundin, Cecilia and Evers, Bastiaan and Ebner, Daniel and Bauerschmidt, Christina and Kingham, Guy and Palmai-Pallag, Timea and Mortusewicz, Oliver and Frings, Oliver and Sonnhammer, Erik and Helleday, Thomas (2015) A genome-wide IR-induced RAD51 foci RNAi screen identifies CDC73 involved in chromatin remodeling for DNA repair. Cell Discovery . p. 15034. ISSN 2056-5968

chromosome

Todd, J. A. and Walker, N. M. and Cooper, J. D. and Smyth, D. J. and Downes, K. and Plagnol, V. and Bailey, R. and Nejentsev, S. and Field, S. F. and Payne, F. and Lowe, C. E. and Szeszko, J. S. and Hafler, J. P. and Zeitels, L. and Yang, J. H. M. and Vella, A. and Nutland, S. and Stevens, H. E. and Schuilenburg, H. and Coleman, G. and Maisuria, M. and Meadows, W. and Smink, L. J. and Healy, B. and Burren, O. S. and Lam, A. A. C. and Ovington, N. R. and Allen, J. and Adlem, E. and Leung, H-T. and Wallace, C. and Howson, J. M. M. and Guja, C. and Ionescu-Tırgoviste, C. and Genetics of T1D in Finland, . and Simmonds, M. J. and Heward, J. M. and Gough, S. C. L. and WTCCC, . and Dunger, D. B. and Wicker, L. S. and Clayton, D. G. (2007) Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nature Genetics, 39 (7). pp. 857-864. ISSN 1061-4036

chromosome 1

Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN 1553-7390

chromosome 14q

Zeitlin, A. A. and Heward, J. M. and Brand, O. J. and Newby, P. R. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2006) Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. Clinical Endocrinology, 65 (3). pp. 380-384. ISSN 0300-0664

chromosome 18q

Hafler, J. P. and Maier, L. M. and Cooper, J. D. and Plagnol, V. and Hinks, A. and Simmonds, M. J. and Stevens, H. and Walker, N. and Healy, B. and Howson, J. M. M. and Maisuria, M. and Duley, S. and Coleman, G. and Gough, S. C. L. and Worthington, J. and Kuchroo, V. K. and Wicker, L. S. and Todd, J. A. and IMSGC, . (2009) CD226 Gly307Ser association with multiple autoimmune diseases. Genes and Immunity, 10 (1). pp. 5-10. ISSN 1466-4879

Todd, J. A. and Walker, N. M. and Cooper, J. D. and Smyth, D. J. and Downes, K. and Plagnol, V. and Bailey, R. and Nejentsev, S. and Field, S. F. and Payne, F. and Lowe, C. E. and Szeszko, J. S. and Hafler, J. P. and Zeitels, L. and Yang, J. H. M. and Vella, A. and Nutland, S. and Stevens, H. E. and Schuilenburg, H. and Coleman, G. and Maisuria, M. and Meadows, W. and Smink, L. J. and Healy, B. and Burren, O. S. and Lam, A. A. C. and Ovington, N. R. and Allen, J. and Adlem, E. and Leung, H-T. and Wallace, C. and Howson, J. M. M. and Guja, C. and Ionescu-Tırgoviste, C. and Genetics of T1D in Finland, . and Simmonds, M. J. and Heward, J. M. and Gough, S. C. L. and WTCCC, . and Dunger, D. B. and Wicker, L. S. and Clayton, D. G. (2007) Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nature Genetics, 39 (7). pp. 857-864. ISSN 1061-4036

chromosome 20q

Heward, J. M. and Simmonds, M. J. and Carr-Smith, J. and Foxall, H. and Franklyn, J. A. and Gough, S. C. L. (2004) A single nucleotide polymorphism in the CD40 gene on chromosome 20q (GD-2) provides no evidence for susceptibility to Graves' disease in UK Caucasians. Clinical Endocrinology, 61 (2). pp. 269-272. ISSN 0300-0664

Simmonds, M. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. (2005) The CD40 Kozak SNP: a new susceptibility loci for Graves' disease? Clinical Endocrinology, 63 (2). pp. 232-233. ISSN 0300 0664

chromosome 2q

Zeitlin, A. and Simmonds, M. J. and Gough, S. C. (2008) Genetic developments in autoimmune thyroid disease: an evolutionary process. Clinical Endocrinology, 68 (5). pp. 671-682. ISSN 0300-0664

chromosome 9

Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN 1553-7390

chromosome 9q

Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN 1553-7390

chromosome aberration

Elmrghni, Samir and Shaw, Michael and Ali, Nadir and Dixon, Ron and Ross Williams, D. (2012) Aberrations of human gender identification by amelogenin test in Libyans (Benghazi city). Indian Journal of Forensic Medicine and Toxicology, 6 (2). pp. 163-166. ISSN 0973-9122

chromosome deletion X

Elmrghni, Samir and Shaw, Michael and Ali, Nadir and Dixon, Ron and Ross Williams, D. (2012) Aberrations of human gender identification by amelogenin test in Libyans (Benghazi city). Indian Journal of Forensic Medicine and Toxicology, 6 (2). pp. 163-166. ISSN 0973-9122

chromosome deletion Y

Elmrghni, Samir and Shaw, Michael and Ali, Nadir and Dixon, Ron and Ross Williams, D. (2012) Aberrations of human gender identification by amelogenin test in Libyans (Benghazi city). Indian Journal of Forensic Medicine and Toxicology, 6 (2). pp. 163-166. ISSN 0973-9122

chromosome identification

Simmonds, M. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. (2005) IL-13 and chromosome 5q31-q33: problems of identifying association within regions of linkage to Graves' disease. Clinical Endocrinology, 63 (6). pp. 695-697. ISSN 0300-0664

chromosome instability

Nielsen, Christian F. and Huttner, Diana and Bizard, Anna H. and Hirano, Seiki and Li, Tian-Neng and Palmai-Pallag, Timea and Bjerregaard, Victoria A. and Liu, Ying and Nigg, Erich A. and Wang, Lily Hui-Ching and Hickson, Ian D. (2015) PICH promotes sister chromatid disjunction and co-operates with topoisomerase II in mitosis. Nature Communications, 6 . p. 8962. ISSN 2041-1723

chromosome missegregation

Nielsen, Christian F. and Huttner, Diana and Bizard, Anna H. and Hirano, Seiki and Li, Tian-Neng and Palmai-Pallag, Timea and Bjerregaard, Victoria A. and Liu, Ying and Nigg, Erich A. and Wang, Lily Hui-Ching and Hickson, Ian D. (2015) PICH promotes sister chromatid disjunction and co-operates with topoisomerase II in mitosis. Nature Communications, 6 . p. 8962. ISSN 2041-1723

chronic kidney disease

Chand, S. and Chue, C. D. and Edwards, N. C. and Hodson, J. and Simmonds, M. J. and Hamilton, A. and Gough, S. C. L. and Harper, L. and Steeds, R. P. and Townend, J. N. and Ferro, C. J. and Borrows, R. (2015) Endothelial nitric oxide synthase single nucleotide polymorphism and left ventricular function in early chronic kidney disease. PLoS ONE, 10 (1). ISSN 1932-6203

cohort analysis

Brand, O. J. and Barrett, J. C. and Simmonds, M. J. and Newby, P. R. and McCabe, C. J. and Bruce, C. K. and Kysela, B. and Carr-Smith, J. D. and Brix, T. and Hunt, P. J. and Wiersinga, W. M. and Hegedus, L. and Connell, J. and Wass, J. A. H. and Franklyn, J. A. and Weetman, A. P. and Heward, J. M. and Gough, S. C. L. (2009) Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves' disease. Human Molecular Genetics, 18 (9). pp. 1704-1713. ISSN 0964-6906

Chand, S. and Chue, C. D. and Edwards, N. C. and Hodson, J. and Simmonds, M. J. and Hamilton, A. and Gough, S. C. L. and Harper, L. and Steeds, R. P. and Townend, J. N. and Ferro, C. J. and Borrows, R. (2015) Endothelial nitric oxide synthase single nucleotide polymorphism and left ventricular function in early chronic kidney disease. PLoS ONE, 10 (1). ISSN 1932-6203

Chand, S. and Holle, J. U. and Hilhorst, M. and Simmonds, M. J. and Smith, S. and Kamesh, L. and Hewins, P. and McKnight, A. J. and Maxwell, A. P. and Willem Cohen Tervaert, J. and Wieczorek, S. and Harper, L. and Borrows, R. (2013) Caveolin-1 single nucleotide polymorphism in antineutrophil cytoplasmic antibody associated vasculitis. PLoS ONE, 8 (7). ISSN 1932-6203

Heward, J. M. and Simmonds, M. J. and Carr-Smith, J. and Foxall, H. and Franklyn, J. A. and Gough, S. C. L. (2004) A single nucleotide polymorphism in the CD40 gene on chromosome 20q (GD-2) provides no evidence for susceptibility to Graves' disease in UK Caucasians. Clinical Endocrinology, 61 (2). pp. 269-272. ISSN 0300-0664

Moore, J. and McKnight, A.J. and Simmonds, M. J. and Courtney, A. E. and Hanvesakul, R. and Brand, O. J. and Briggs, D. and Ball, S. and Cockwell, P. and Patterson, C.C. and Maxwell, A. P. and Gough, S. C. L. and Borrows, R. (2010) Association of caveolin-1 gene polymorphism with kidney transplant fibrosis and allograft failure. JAMA - Journal of the American Medical Association, 303 (13). pp. 1282-1287. ISSN 0098-7484

Simmonds, Matthew J. and Benavente, David and Brand, Oliver J. and Moore, Jason and Ball, Simon and Ferro, Charles J. and Briggs, David and Gough, Stephen C. L. and Borrows, Richard J. (2013) Skewing of female X-chromosome inactivation: an epigenetic risk factor for kidney transplantation outcome. Transplantation, 95 (5). e25-e28. ISSN 0041-1337

comparative study

Newby, P. R. and Roberts-Davies, E. L. and Brand, O. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2007) Tag SNP screening of the PDCD1 gene for association with Graves' disease. Clinical Endocrinology, 67 (1). pp. 125-128. ISSN 0300-0664

complementary DNA

Simmonds, M. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. (2005) The CD40 Kozak SNP: a new susceptibility loci for Graves' disease? Clinical Endocrinology, 63 (2). pp. 232-233. ISSN 0300 0664

confidence interval

Newby, P. R. and Roberts-Davies, E. L. and Brand, O. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2007) Tag SNP screening of the PDCD1 gene for association with Graves' disease. Clinical Endocrinology, 67 (1). pp. 125-128. ISSN 0300-0664

congenital

Southgate, Laura and Sukalo, Maja and Karountzos, Anastasios S. V. and Taylor, Edward J. and Collinson, Claire S. and Ruddy, Deborah and Snape, Katie M. and Dallapiccola, Bruno and Tolmie, John L. and Joss, Shelagh and Brancati, Francesco and Digilio, M. Cristina and Graul-Neumann, Luitgard M. and Salviati, Leonardo and Coerdt, Wiltrud and Jacquemin, Emmanuel and Wuyts, Wim and Zenker, Martin and Machado, Rajiv D. and Trembath, Richard C. (2015) Haploinsufficiency of the NOTCH1 receptor as a cause of Adams-Oliver Syndrome with variable cardiac anomalies. Circulation: Cardiovascular genetics, 8 (4). ISSN 1942-325X

controlled study

Brand, O. J. and Barrett, J. C. and Simmonds, M. J. and Newby, P. R. and McCabe, C. J. and Bruce, C. K. and Kysela, B. and Carr-Smith, J. D. and Brix, T. and Hunt, P. J. and Wiersinga, W. M. and Hegedus, L. and Connell, J. and Wass, J. A. H. and Franklyn, J. A. and Weetman, A. P. and Heward, J. M. and Gough, S. C. L. (2009) Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves' disease. Human Molecular Genetics, 18 (9). pp. 1704-1713. ISSN 0964-6906

Chand, S. and Chue, C. D. and Edwards, N. C. and Hodson, J. and Simmonds, M. J. and Hamilton, A. and Gough, S. C. L. and Harper, L. and Steeds, R. P. and Townend, J. N. and Ferro, C. J. and Borrows, R. (2015) Endothelial nitric oxide synthase single nucleotide polymorphism and left ventricular function in early chronic kidney disease. PLoS ONE, 10 (1). ISSN 1932-6203

Cooper, J. D. and Simmonds, M. J. and Walker, N.M. and Burren, O. and Brand, O.J. and Guo, H. and Wallace, C. and Stevens, H. and Coleman, G and Franklyn, J.A. and Todd, J.A. and Gough, S.C.L. (2012) Seven newly identified loci for autoimmune thyroid disease. Human Molecular Genetics, 21 (23). pp. 5202-5208. ISSN 0964-6906

Elmrghni, Samir and Shaw, Michael and Ali, Nadir and Dixon, Ron and Ross Williams, D. (2012) Aberrations of human gender identification by amelogenin test in Libyans (Benghazi city). Indian Journal of Forensic Medicine and Toxicology, 6 (2). pp. 163-166. ISSN 0973-9122

Hafler, J. P. and Maier, L. M. and Cooper, J. D. and Plagnol, V. and Hinks, A. and Simmonds, M. J. and Stevens, H. and Walker, N. and Healy, B. and Howson, J. M. M. and Maisuria, M. and Duley, S. and Coleman, G. and Gough, S. C. L. and Worthington, J. and Kuchroo, V. K. and Wicker, L. S. and Todd, J. A. and IMSGC, . (2009) CD226 Gly307Ser association with multiple autoimmune diseases. Genes and Immunity, 10 (1). pp. 5-10. ISSN 1466-4879

Heward, J. M. and Simmonds, M. J. and Carr-Smith, J. and Foxall, H. and Franklyn, J. A. and Gough, S. C. L. (2004) A single nucleotide polymorphism in the CD40 gene on chromosome 20q (GD-2) provides no evidence for susceptibility to Graves' disease in UK Caucasians. Clinical Endocrinology, 61 (2). pp. 269-272. ISSN 0300-0664

Hunt, K. A. and Mistry, V. and Bockett, N. A. and Ahmad, T. and Ban, M. and Barker, J. N. and Barrett, J. C. and Blackburn, H. and Brand, O. J. and Burren, O. and Capon, F. and Compston, A. and Gough, S. C. L. and Jostins, L. and Kong, Y. and Lee, J. C. and Lek, M. and MacArthur, D. G. and Mansfield, J. C. and Mathew, C. G. and Mein, C. A. and Mirza, M. and Nutland, S. and Onengut-Gumuscu, S. and Papouli, E. and Parkes, M. and Rich, S. S. and Sawcer, S. and Satsangi, J. and Simmonds, M. J. and Trembath, R. C. and Walker, N. M. and Wozniak, E. and Todd, J. A. and Simpson, M. A. and Plagnol, V. and van Heel, D. A. (2013) Negligible impact of rare autoimmune-locus coding-region variants on missing heritability. Nature, 498 (7453). pp. 232-235. ISSN 0028-0836

Hunt, K. A. and Smyth, D. J. and Balschun, T. and Ban, M. and Mistry, V. and Ahmed, T. and Barrett, J. C. and Bhaw-Rosun, L. and Bockett, N. A. and Brand, O. J. and Brouwer, E. and Concannon, P. and Cooper, J. D. and Dias, K-R. M. and van Diemen, C. C. and Dubois, P.C. and Edkins, S. and Fölster-Holst, R. and Fransen, K. and Glass, D. N. and Heap, G. A. R. and Hofmann, S. and Huizinga, T. W. J. and Hunt, S. and Langford, C. and Lee, J. and Mansfield, J. and Giovanna Marrosu, M. and Mathew, C. G. and Mein, C.A. and Müller-Quernheim, J. and Nutland, S. and Onengut-Gumuscu, S. and Ouwehand, W. and Pearce, K. and Prescott, N. and Posthumus, M. D. and Potter, S. and Rosati, G. and Sambrook, J. and Satsangi, J. and Schreiber, S. and Shtir, C. and Simmonds, M. J. and Sudman, M. and Thompson, S. D. and Toes, R. and Trynka, G. and Vyse, T. J. and Walker, N. M. and Weidinger, S. and Zhernakova, A. and Zoledziewska, M. and Weersma, R.K. and Gough, S.C.L. and Sawcer, S. and Wijmenga, C. and Parkes, M. and Cucca, F. and Franke, A. and Deloukas, P. and Rich, S. S. and Todd, J. A. and van Heel, D. A. (2011) Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry. Nature Genetics, 44 (1). pp. 3-5. ISSN 10614036

Medici, M. and Porcu, E. and Pistis, G. and Teumer, A. and Brown, S. J. and Jensen, R. A. and Rawal, R. and Roef, G. L. and Plantinga, T. S. and Vermeulen, S. H. and Lahti, J. and Simmonds, M. J. and Husemoen, L. N. N. and Freathy, R. M. and Shields, B. M. and Pietzner, D. and Nagy, R. and Broer, L. and Chaker, L. and Korevaar, T. I. M. and Plia, M. G. and Sala, C. and Volker, U. and Richards, J. B. and Sweep, F. C. and Gieger, C. and Corre, T. and Kajantie, E. and Thuesen, B. and Taes, Y. E. and Visser, W. E. and Hattersley, A. T. and Kratzsch, J. and Hamilton, A. and Li, W. and Homuth, G. and Lobina, M. and Mariotti, S. and Soranzo, N. and Cocca, M. and Nauck, M. and Spielhagen, C. and Ross, A. and Arnold, A. and van de Bunt, M. and Liyanarachchi, S. and Heier, M. and Grabe, H. J. and Masciullo, C. and Galesloot, T. E. and Lim, E. M. and Reischl, E. and Leedman, P. J. and Lai, S. and Delitala, A. and Bremner, A. P. and Philips, D. I. W. and Beilby, J. P. and Mulas, A. and Vocale, M. and Abecasis, G. and Forsen, T. and James, A. and Widen, E. and Hui, J. and Prokisch, H. and Rietzschel, E. E. and Palotie, A. and Feddema, P. and Fletcher, S. J. and Schramm, K. and Rotter, J. I. and Kluttig, A. and Radke, D. and Traglia, M. and Surdulescu, G. L. and He, H. and Franklyn, J. A. and Tiller, D. and Vaidya, B. and de Meyer, T. and Jørgensen, T. and Eriksson, J. G. and O’Leary, P. C. and Wichmann, E. and Hermus, A. R. and Psaty, B. M. and Ittermann, T. and Hofman, A. and Bosi, E. and Schlessinger, D. and Wallaschofski, H. and Pirastu, N. and Aulchenko, Y.S. and de la Chapelle, A. and Netea-Maier, R.T. and Gough, S.C.L. and Meyer zu Schwabedissen, H. and Frayling, T.M. and Kaufman, J.M. and Linneberg, A. and Raikkonen, K. and Smit, J.W.A. and Kiemeney, L.A. and Rivadeneira, F. and Uitterlinden, A.G. and Walsh, J.P. and Meisinger, C. and den Heijer, M. and Visser, T.J. and Spector, T.D. and Wilson, S.G. and Volzke, H. and Cappola, A. and Toniolo, D. and Sanna, S. and Naitza, S. and Peeters, R.P. (2014) Identification of novel genetic loci associated with thyroid peroxidase antibodies and clinical thyroid disease. PLoS Genetics, 10 (2). ISSN 15537390

Moore, J. and McKnight, A.J. and Simmonds, M. J. and Courtney, A. E. and Hanvesakul, R. and Brand, O. J. and Briggs, D. and Ball, S. and Cockwell, P. and Patterson, C.C. and Maxwell, A. P. and Gough, S. C. L. and Borrows, R. (2010) Association of caveolin-1 gene polymorphism with kidney transplant fibrosis and allograft failure. JAMA - Journal of the American Medical Association, 303 (13). pp. 1282-1287. ISSN 0098-7484

Moore, Jason and McKnight, Amy Jayne and Döhler, Bernd and Simmonds, Matthew J. and Courtney, Aisling E. and Brand, Oliver J. and Briggs, David and Ball, Simon and Cockwell, Paul and Patterson, Christopher C. and Maxwell, Alexander P. and Gough, Stephen C. L. and Opelz, Gerhard and Borrows, Richard (2012) Donor ABCB1 variant associates with increased risk for kidney allograft failure. Journal of the American Society of Nephrology, 23 (11). pp. 1891-1899. ISSN 1046-6673

Newby, P. R. and Roberts-Davies, E. L. and Brand, O. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2007) Tag SNP screening of the PDCD1 gene for association with Graves' disease. Clinical Endocrinology, 67 (1). pp. 125-128. ISSN 0300-0664

Newby, Paul R. and Pickles, Oliver J. and Mazumdar, Samaresh and Brand, Oliver J. and Carr-Smith, Jacqueline D. and Pearce, Simon H. S. and Franklyn, Jayne A. and Evans, David M. and Simmonds, Matthew J. and Gough, Stephen C. L. and Welcome Trust Case-Control Consortium (WTCCC), . (2010) Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study. European Journal of Human Genetics, 18 (9). pp. 1021-1026. ISSN 1018-4813

Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN 1553-7390

Simmonds, M. J. and Heward, J. M. and Barrett, J. C. and Franklyn, J. A. and Gough, S. C. L. (2006) Association of the BTNL2 rs2076530 single nucleotide polymorphism with Graves' disease appears to be secondary to DRB1 exon 2 position beta74. Clinical Endocrinology, 65 (4). pp. 429-432. ISSN 0300-0664

Simmonds, M. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. (2005) IL-13 and chromosome 5q31-q33: problems of identifying association within regions of linkage to Graves' disease. Clinical Endocrinology, 63 (6). pp. 695-697. ISSN 0300-0664

Simmonds, M. J. and Heward, J.M. and Howson, J.M.M. and Foxall, H. and Nithiyananthan, R. and Franklyn, J.A. and Gough, S.C.L. (2004) A systematic approach to the assesment of known TNF-alpha polymorphisms in Graves' disease. Genes and Immunity, 5 (4). pp. 267-273. ISSN 1466-4879

Simmonds, M. J. and Howson, J. M. M. and Heward, J. M. and Carr-Smith, J. and Franklyn, J. A. and Todd, J. A. and Gough, S. C. L. (2007) A novel and major association of HLA-C in Graves' disease that eclipses the classical HLA-DRB1 effect. Human Molecular Genetics, 16 (18). pp. 2149-2153. ISSN 0964-6906

Simmonds, Matthew J. and Brand, Oliver J. and Barrett, Jeffrey C. and Newby, Paul R. and Franklyn, Jayne A. and Gough, Stephen C. L. (2010) Association of Fc receptor-like 5 (FCRL5) with Graves' disease is secondary to the effect of FCRL3. Clinical Endocrinology, 73 (5). pp. 654-660. ISSN 0300-0664

Simmonds, Matthew J. and Heward, J. M. and Carr-Smith, J. and Foxall, H. and Franklyn, J. A. and Gough, S. C. L. (2006) Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease. Journal of Clinical Endocrinology and Metabolism, 91 (3). pp. 1056-1061. ISSN 0021-972X

Simmonds, Matthew J. and Howson, Joanna M. M. and Heward, Joanne M. and Cordell, Heather J. and Foxall, Helen and Carr-Smith, Jackie and Gibson, Sarah M. and Walker, Neil and Tomer, Yaron and Franklyn, Jayne A. and Todd, John A. and Gough, Stephen C. L. (2005) Regression mapping of association between the human leukocyte antigen region and Graves' disease. American Journal of Human Genetics, 76 (1). pp. 157-163. ISSN 0002-9297

Todd, J. A. and Walker, N. M. and Cooper, J. D. and Smyth, D. J. and Downes, K. and Plagnol, V. and Bailey, R. and Nejentsev, S. and Field, S. F. and Payne, F. and Lowe, C. E. and Szeszko, J. S. and Hafler, J. P. and Zeitels, L. and Yang, J. H. M. and Vella, A. and Nutland, S. and Stevens, H. E. and Schuilenburg, H. and Coleman, G. and Maisuria, M. and Meadows, W. and Smink, L. J. and Healy, B. and Burren, O. S. and Lam, A. A. C. and Ovington, N. R. and Allen, J. and Adlem, E. and Leung, H-T. and Wallace, C. and Howson, J. M. M. and Guja, C. and Ionescu-Tırgoviste, C. and Genetics of T1D in Finland, . and Simmonds, M. J. and Heward, J. M. and Gough, S. C. L. and WTCCC, . and Dunger, D. B. and Wicker, L. S. and Clayton, D. G. (2007) Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nature Genetics, 39 (7). pp. 857-864. ISSN 1061-4036

Yesmin, K. and Hargreaves, C. and Newby, P. R. and Brand, O. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2010) Association of FcGRIIa with Graves' disease: a potential role for dysregulated autoantibody clearance in disease onset/progression. Clinical Endocrinology, 73 (1). pp. 119-125. ISSN 0300-0664

Zeitlin, A. A. and Heward, J. M. and Brand, O. J. and Newby, P. R. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2006) Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. Clinical Endocrinology, 65 (3). pp. 380-384. ISSN 0300-0664

Zeitlin, A. A. and Heward, J. M. and Newby, P. R. and Carr-Smith, J. D. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2008) Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. Genes and Immunity, 9 (4). pp. 358-363. ISSN 1466-4879

copy number variation

Simmonds, Matthew J. (2013) GWAS in autoimmune thyroid disease: redefining our understanding of pathogenesis. Nature Reviews Endocrinology, 9 (5). pp. 277-287. ISSN 1759-5029

Simmonds, Matthew J. and Gough, Stephen C. L. (2011) The search for the genetic contribution to autoimmune thyroid disease: The never ending story? Briefings in Functional Genomics, 10 (2). pp. 77-90. ISSN 2041-2649

cyclophilin

Moore, Jason and McKnight, Amy Jayne and Döhler, Bernd and Simmonds, Matthew J. and Courtney, Aisling E. and Brand, Oliver J. and Briggs, David and Ball, Simon and Cockwell, Paul and Patterson, Christopher C. and Maxwell, Alexander P. and Gough, Stephen C. L. and Opelz, Gerhard and Borrows, Richard (2012) Donor ABCB1 variant associates with increased risk for kidney allograft failure. Journal of the American Society of Nephrology, 23 (11). pp. 1891-1899. ISSN 1046-6673

cytochrome P450 3A4

Moore, Jason and McKnight, Amy Jayne and Döhler, Bernd and Simmonds, Matthew J. and Courtney, Aisling E. and Brand, Oliver J. and Briggs, David and Ball, Simon and Cockwell, Paul and Patterson, Christopher C. and Maxwell, Alexander P. and Gough, Stephen C. L. and Opelz, Gerhard and Borrows, Richard (2012) Donor ABCB1 variant associates with increased risk for kidney allograft failure. Journal of the American Society of Nephrology, 23 (11). pp. 1891-1899. ISSN 1046-6673

cytochrome P450 3A5

Moore, Jason and McKnight, Amy Jayne and Döhler, Bernd and Simmonds, Matthew J. and Courtney, Aisling E. and Brand, Oliver J. and Briggs, David and Ball, Simon and Cockwell, Paul and Patterson, Christopher C. and Maxwell, Alexander P. and Gough, Stephen C. L. and Opelz, Gerhard and Borrows, Richard (2012) Donor ABCB1 variant associates with increased risk for kidney allograft failure. Journal of the American Society of Nephrology, 23 (11). pp. 1891-1899. ISSN 1046-6673

cytotoxic T lymphocyte antigen 4

Simmonds, M. J. and Gough, S. C. L. (2004) Unravelling the genetic complexity of autoimmune thyroid disease: HLA, CTLA-4 and beyond. Clinical and Experimental Immunology, 136 (1). pp. 1-10. ISSN 0009-9104

Simmonds, Matthew and Gough, S. C. L. (2005) Genetic insights into disease mechanisms of autoimmunity. British Medical Bulletin, 71 (1). pp. 93-113. ISSN 0007-1420

Zeitlin, A. and Simmonds, M. J. and Gough, S. C. (2008) Genetic developments in autoimmune thyroid disease: an evolutionary process. Clinical Endocrinology, 68 (5). pp. 671-682. ISSN 0300-0664

deoxyribonuclease I, autoimmune disease

Simmonds, Matthew J. and Heward, Joanne M. and Kelly, M. Ann and Allahabadia, Amit and Foxall, Helen and Gordon, Caroline and Franklyn, Jayne A. and Gough, Stephen C. L. (2002) A nonsense mutation in exon 2 of the DNase I gene is not present in UK subjects with systemic lupus erythematosus and Graves' disease: Comment on the article by Rood et al. Arthritis and Rheumatism, 46 (11). pp. 3109-3110. ISSN 0004-3591

diagnostic equipment

Ali, Nadir and Coulson-Thomas, Yvette M. and Norton, Andrew L. and Dixon, Ronald A. and Williams, D. Ross (2013) Announcement of population data: genetic data for 17 Y-STR AmpFℓSTR® Yfiler™ markers from an immigrant Pakistani population in the UK (British Pakistanis). Forensic Science International: Genetics, 7 (2). e40-e42. ISSN 1872-4973

dialysis

Moore, J. and McKnight, A.J. and Simmonds, M. J. and Courtney, A. E. and Hanvesakul, R. and Brand, O. J. and Briggs, D. and Ball, S. and Cockwell, P. and Patterson, C.C. and Maxwell, A. P. and Gough, S. C. L. and Borrows, R. (2010) Association of caveolin-1 gene polymorphism with kidney transplant fibrosis and allograft failure. JAMA - Journal of the American Medical Association, 303 (13). pp. 1282-1287. ISSN 0098-7484

digital

Hudson, John (2011) All watched over by machines of loving grace: part 3 "The monkey in the machine and the machine in the monkey". Digital Imaging and Photography . ISSN UNSPECIFIED

disease association

Chand, S. and Chue, C. D. and Edwards, N. C. and Hodson, J. and Simmonds, M. J. and Hamilton, A. and Gough, S. C. L. and Harper, L. and Steeds, R. P. and Townend, J. N. and Ferro, C. J. and Borrows, R. (2015) Endothelial nitric oxide synthase single nucleotide polymorphism and left ventricular function in early chronic kidney disease. PLoS ONE, 10 (1). ISSN 1932-6203

Hunt, K. A. and Mistry, V. and Bockett, N. A. and Ahmad, T. and Ban, M. and Barker, J. N. and Barrett, J. C. and Blackburn, H. and Brand, O. J. and Burren, O. and Capon, F. and Compston, A. and Gough, S. C. L. and Jostins, L. and Kong, Y. and Lee, J. C. and Lek, M. and MacArthur, D. G. and Mansfield, J. C. and Mathew, C. G. and Mein, C. A. and Mirza, M. and Nutland, S. and Onengut-Gumuscu, S. and Papouli, E. and Parkes, M. and Rich, S. S. and Sawcer, S. and Satsangi, J. and Simmonds, M. J. and Trembath, R. C. and Walker, N. M. and Wozniak, E. and Todd, J. A. and Simpson, M. A. and Plagnol, V. and van Heel, D. A. (2013) Negligible impact of rare autoimmune-locus coding-region variants on missing heritability. Nature, 498 (7453). pp. 232-235. ISSN 0028-0836

Newby, P. R. and Roberts-Davies, E. L. and Brand, O. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2007) Tag SNP screening of the PDCD1 gene for association with Graves' disease. Clinical Endocrinology, 67 (1). pp. 125-128. ISSN 0300-0664

Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN 1553-7390

Simmonds, M. J. and Heward, J. M. and Barrett, J. C. and Franklyn, J. A. and Gough, S. C. L. (2006) Association of the BTNL2 rs2076530 single nucleotide polymorphism with Graves' disease appears to be secondary to DRB1 exon 2 position beta74. Clinical Endocrinology, 65 (4). pp. 429-432. ISSN 0300-0664

Simmonds, M. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. (2005) IL-13 and chromosome 5q31-q33: problems of identifying association within regions of linkage to Graves' disease. Clinical Endocrinology, 63 (6). pp. 695-697. ISSN 0300-0664

Zeitlin, A. A. and Heward, J. M. and Brand, O. J. and Newby, P. R. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2006) Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. Clinical Endocrinology, 65 (3). pp. 380-384. ISSN 0300-0664

Zeitlin, A. A. and Heward, J. M. and Newby, P. R. and Carr-Smith, J. D. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2008) Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. Genes and Immunity, 9 (4). pp. 358-363. ISSN 1466-4879

disease classification

Simmonds, Matthew and Gough, S. C. L. (2005) Genetic insights into disease mechanisms of autoimmunity. British Medical Bulletin, 71 (1). pp. 93-113. ISSN 0007-1420

disease course

Gough, S .C. L. and Simmonds, Matthew J. (2007) The HLA region and autoimmune disease: associations and mechanisms of action. Current Genomics, 8 (7). pp. 453-465. ISSN 1389-2029

Simmonds, Matthew J. (2013) GWAS in autoimmune thyroid disease: redefining our understanding of pathogenesis. Nature Reviews Endocrinology, 9 (5). pp. 277-287. ISSN 1759-5029

Yesmin, K. and Hargreaves, C. and Newby, P. R. and Brand, O. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2010) Association of FcGRIIa with Graves' disease: a potential role for dysregulated autoantibody clearance in disease onset/progression. Clinical Endocrinology, 73 (1). pp. 119-125. ISSN 0300-0664

Zeitlin, A. A. and Heward, J. M. and Newby, P. R. and Carr-Smith, J. D. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2008) Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. Genes and Immunity, 9 (4). pp. 358-363. ISSN 1466-4879

disease incidence

Hunt, K. A. and Mistry, V. and Bockett, N. A. and Ahmad, T. and Ban, M. and Barker, J. N. and Barrett, J. C. and Blackburn, H. and Brand, O. J. and Burren, O. and Capon, F. and Compston, A. and Gough, S. C. L. and Jostins, L. and Kong, Y. and Lee, J. C. and Lek, M. and MacArthur, D. G. and Mansfield, J. C. and Mathew, C. G. and Mein, C. A. and Mirza, M. and Nutland, S. and Onengut-Gumuscu, S. and Papouli, E. and Parkes, M. and Rich, S. S. and Sawcer, S. and Satsangi, J. and Simmonds, M. J. and Trembath, R. C. and Walker, N. M. and Wozniak, E. and Todd, J. A. and Simpson, M. A. and Plagnol, V. and van Heel, D. A. (2013) Negligible impact of rare autoimmune-locus coding-region variants on missing heritability. Nature, 498 (7453). pp. 232-235. ISSN 0028-0836

disease model

Simmonds, M. J. and Gough, S. C. L. (2004) Unravelling the genetic complexity of autoimmune thyroid disease: HLA, CTLA-4 and beyond. Clinical and Experimental Immunology, 136 (1). pp. 1-10. ISSN 0009-9104

disease predisposition

Simmonds, M. J. and Heward, J. M. and Barrett, J. C. and Franklyn, J. A. and Gough, S. C. L. (2006) Association of the BTNL2 rs2076530 single nucleotide polymorphism with Graves' disease appears to be secondary to DRB1 exon 2 position beta74. Clinical Endocrinology, 65 (4). pp. 429-432. ISSN 0300-0664

donor

Moore, J. and McKnight, A.J. and Simmonds, M. J. and Courtney, A. E. and Hanvesakul, R. and Brand, O. J. and Briggs, D. and Ball, S. and Cockwell, P. and Patterson, C.C. and Maxwell, A. P. and Gough, S. C. L. and Borrows, R. (2010) Association of caveolin-1 gene polymorphism with kidney transplant fibrosis and allograft failure. JAMA - Journal of the American Medical Association, 303 (13). pp. 1282-1287. ISSN 0098-7484

drug design

Simmonds, Matthew and Gough, S. C. L. (2005) Genetic insights into disease mechanisms of autoimmunity. British Medical Bulletin, 71 (1). pp. 93-113. ISSN 0007-1420

endothelial nitric oxide synthase, adult

Chand, S. and Chue, C. D. and Edwards, N. C. and Hodson, J. and Simmonds, M. J. and Hamilton, A. and Gough, S. C. L. and Harper, L. and Steeds, R. P. and Townend, J. N. and Ferro, C. J. and Borrows, R. (2015) Endothelial nitric oxide synthase single nucleotide polymorphism and left ventricular function in early chronic kidney disease. PLoS ONE, 10 (1). ISSN 1932-6203

environmental factor

Simmonds, M. J. and Gough, S. C. L. (2004) Unravelling the genetic complexity of autoimmune thyroid disease: HLA, CTLA-4 and beyond. Clinical and Experimental Immunology, 136 (1). pp. 1-10. ISSN 0009-9104

enzyme activity

Hunt, K. A. and Smyth, D. J. and Balschun, T. and Ban, M. and Mistry, V. and Ahmed, T. and Barrett, J. C. and Bhaw-Rosun, L. and Bockett, N. A. and Brand, O. J. and Brouwer, E. and Concannon, P. and Cooper, J. D. and Dias, K-R. M. and van Diemen, C. C. and Dubois, P.C. and Edkins, S. and Fölster-Holst, R. and Fransen, K. and Glass, D. N. and Heap, G. A. R. and Hofmann, S. and Huizinga, T. W. J. and Hunt, S. and Langford, C. and Lee, J. and Mansfield, J. and Giovanna Marrosu, M. and Mathew, C. G. and Mein, C.A. and Müller-Quernheim, J. and Nutland, S. and Onengut-Gumuscu, S. and Ouwehand, W. and Pearce, K. and Prescott, N. and Posthumus, M. D. and Potter, S. and Rosati, G. and Sambrook, J. and Satsangi, J. and Schreiber, S. and Shtir, C. and Simmonds, M. J. and Sudman, M. and Thompson, S. D. and Toes, R. and Trynka, G. and Vyse, T. J. and Walker, N. M. and Weidinger, S. and Zhernakova, A. and Zoledziewska, M. and Weersma, R.K. and Gough, S.C.L. and Sawcer, S. and Wijmenga, C. and Parkes, M. and Cucca, F. and Franke, A. and Deloukas, P. and Rich, S. S. and Todd, J. A. and van Heel, D. A. (2011) Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry. Nature Genetics, 44 (1). pp. 3-5. ISSN 10614036

epigenetics

Simmonds, Matthew J. and Benavente, David and Brand, Oliver J. and Moore, Jason and Ball, Simon and Ferro, Charles J. and Briggs, David and Gough, Stephen C. L. and Borrows, Richard J. (2013) Skewing of female X-chromosome inactivation: an epigenetic risk factor for kidney transplantation outcome. Transplantation, 95 (5). e25-e28. ISSN 0041-1337

ethnic difference

Simmonds, Matthew J. and Gough, Stephen C. L. (2011) The search for the genetic contribution to autoimmune thyroid disease: The never ending story? Briefings in Functional Genomics, 10 (2). pp. 77-90. ISSN 2041-2649

ethnology

Zeitlin, A. A. and Heward, J. M. and Brand, O. J. and Newby, P. R. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2006) Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. Clinical Endocrinology, 65 (3). pp. 380-384. ISSN 0300-0664

exon

Hafler, J. P. and Maier, L. M. and Cooper, J. D. and Plagnol, V. and Hinks, A. and Simmonds, M. J. and Stevens, H. and Walker, N. and Healy, B. and Howson, J. M. M. and Maisuria, M. and Duley, S. and Coleman, G. and Gough, S. C. L. and Worthington, J. and Kuchroo, V. K. and Wicker, L. S. and Todd, J. A. and IMSGC, . (2009) CD226 Gly307Ser association with multiple autoimmune diseases. Genes and Immunity, 10 (1). pp. 5-10. ISSN 1466-4879

Hunt, K. A. and Mistry, V. and Bockett, N. A. and Ahmad, T. and Ban, M. and Barker, J. N. and Barrett, J. C. and Blackburn, H. and Brand, O. J. and Burren, O. and Capon, F. and Compston, A. and Gough, S. C. L. and Jostins, L. and Kong, Y. and Lee, J. C. and Lek, M. and MacArthur, D. G. and Mansfield, J. C. and Mathew, C. G. and Mein, C. A. and Mirza, M. and Nutland, S. and Onengut-Gumuscu, S. and Papouli, E. and Parkes, M. and Rich, S. S. and Sawcer, S. and Satsangi, J. and Simmonds, M. J. and Trembath, R. C. and Walker, N. M. and Wozniak, E. and Todd, J. A. and Simpson, M. A. and Plagnol, V. and van Heel, D. A. (2013) Negligible impact of rare autoimmune-locus coding-region variants on missing heritability. Nature, 498 (7453). pp. 232-235. ISSN 0028-0836

Simmonds, M. J. and Heward, J. M. and Barrett, J. C. and Franklyn, J. A. and Gough, S. C. L. (2006) Association of the BTNL2 rs2076530 single nucleotide polymorphism with Graves' disease appears to be secondary to DRB1 exon 2 position beta74. Clinical Endocrinology, 65 (4). pp. 429-432. ISSN 0300-0664

Simmonds, Matthew J. and Heward, Joanne M. and Kelly, M. Ann and Allahabadia, Amit and Foxall, Helen and Gordon, Caroline and Franklyn, Jayne A. and Gough, Stephen C. L. (2002) A nonsense mutation in exon 2 of the DNase I gene is not present in UK subjects with systemic lupus erythematosus and Graves' disease: Comment on the article by Rood et al. Arthritis and Rheumatism, 46 (11). pp. 3109-3110. ISSN 0004-3591

female

Boelaert, Kristien and Newby, Paul R. and Simmonds, Matthew J. and Holder, Roger L. and Carr-Smith, Jacqueline D. and Heward, Joanne M. and Manji, Nilusha and Allahabadia, Amit and Armitage, Mary and Chatterjee, Krishna V. and Lazarus, John H. and Pearce, Simon H. and Vaidya, Bijay and Gough, Stephen C. and Franklyn, Jayne A. (2010) Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease. American Journal of Medicine, 123 (2). 183.e1-183.e9. ISSN 0002-9343

Chand, S. and Chue, C. D. and Edwards, N. C. and Hodson, J. and Simmonds, M. J. and Hamilton, A. and Gough, S. C. L. and Harper, L. and Steeds, R. P. and Townend, J. N. and Ferro, C. J. and Borrows, R. (2015) Endothelial nitric oxide synthase single nucleotide polymorphism and left ventricular function in early chronic kidney disease. PLoS ONE, 10 (1). ISSN 1932-6203

Chand, S. and Holle, J. U. and Hilhorst, M. and Simmonds, M. J. and Smith, S. and Kamesh, L. and Hewins, P. and McKnight, A. J. and Maxwell, A. P. and Willem Cohen Tervaert, J. and Wieczorek, S. and Harper, L. and Borrows, R. (2013) Caveolin-1 single nucleotide polymorphism in antineutrophil cytoplasmic antibody associated vasculitis. PLoS ONE, 8 (7). ISSN 1932-6203

Cooper, J. D. and Simmonds, M. J. and Walker, N.M. and Burren, O. and Brand, O.J. and Guo, H. and Wallace, C. and Stevens, H. and Coleman, G and Franklyn, J.A. and Todd, J.A. and Gough, S.C.L. (2012) Seven newly identified loci for autoimmune thyroid disease. Human Molecular Genetics, 21 (23). pp. 5202-5208. ISSN 0964-6906

Elmrghni, Samir and Shaw, Michael and Ali, Nadir and Dixon, Ron and Ross Williams, D. (2012) Aberrations of human gender identification by amelogenin test in Libyans (Benghazi city). Indian Journal of Forensic Medicine and Toxicology, 6 (2). pp. 163-166. ISSN 0973-9122

Hafler, J. P. and Maier, L. M. and Cooper, J. D. and Plagnol, V. and Hinks, A. and Simmonds, M. J. and Stevens, H. and Walker, N. and Healy, B. and Howson, J. M. M. and Maisuria, M. and Duley, S. and Coleman, G. and Gough, S. C. L. and Worthington, J. and Kuchroo, V. K. and Wicker, L. S. and Todd, J. A. and IMSGC, . (2009) CD226 Gly307Ser association with multiple autoimmune diseases. Genes and Immunity, 10 (1). pp. 5-10. ISSN 1466-4879

Medici, M. and Porcu, E. and Pistis, G. and Teumer, A. and Brown, S. J. and Jensen, R. A. and Rawal, R. and Roef, G. L. and Plantinga, T. S. and Vermeulen, S. H. and Lahti, J. and Simmonds, M. J. and Husemoen, L. N. N. and Freathy, R. M. and Shields, B. M. and Pietzner, D. and Nagy, R. and Broer, L. and Chaker, L. and Korevaar, T. I. M. and Plia, M. G. and Sala, C. and Volker, U. and Richards, J. B. and Sweep, F. C. and Gieger, C. and Corre, T. and Kajantie, E. and Thuesen, B. and Taes, Y. E. and Visser, W. E. and Hattersley, A. T. and Kratzsch, J. and Hamilton, A. and Li, W. and Homuth, G. and Lobina, M. and Mariotti, S. and Soranzo, N. and Cocca, M. and Nauck, M. and Spielhagen, C. and Ross, A. and Arnold, A. and van de Bunt, M. and Liyanarachchi, S. and Heier, M. and Grabe, H. J. and Masciullo, C. and Galesloot, T. E. and Lim, E. M. and Reischl, E. and Leedman, P. J. and Lai, S. and Delitala, A. and Bremner, A. P. and Philips, D. I. W. and Beilby, J. P. and Mulas, A. and Vocale, M. and Abecasis, G. and Forsen, T. and James, A. and Widen, E. and Hui, J. and Prokisch, H. and Rietzschel, E. E. and Palotie, A. and Feddema, P. and Fletcher, S. J. and Schramm, K. and Rotter, J. I. and Kluttig, A. and Radke, D. and Traglia, M. and Surdulescu, G. L. and He, H. and Franklyn, J. A. and Tiller, D. and Vaidya, B. and de Meyer, T. and Jørgensen, T. and Eriksson, J. G. and O’Leary, P. C. and Wichmann, E. and Hermus, A. R. and Psaty, B. M. and Ittermann, T. and Hofman, A. and Bosi, E. and Schlessinger, D. and Wallaschofski, H. and Pirastu, N. and Aulchenko, Y.S. and de la Chapelle, A. and Netea-Maier, R.T. and Gough, S.C.L. and Meyer zu Schwabedissen, H. and Frayling, T.M. and Kaufman, J.M. and Linneberg, A. and Raikkonen, K. and Smit, J.W.A. and Kiemeney, L.A. and Rivadeneira, F. and Uitterlinden, A.G. and Walsh, J.P. and Meisinger, C. and den Heijer, M. and Visser, T.J. and Spector, T.D. and Wilson, S.G. and Volzke, H. and Cappola, A. and Toniolo, D. and Sanna, S. and Naitza, S. and Peeters, R.P. (2014) Identification of novel genetic loci associated with thyroid peroxidase antibodies and clinical thyroid disease. PLoS Genetics, 10 (2). ISSN 15537390

Moore, J. and McKnight, A.J. and Simmonds, M. J. and Courtney, A. E. and Hanvesakul, R. and Brand, O. J. and Briggs, D. and Ball, S. and Cockwell, P. and Patterson, C.C. and Maxwell, A. P. and Gough, S. C. L. and Borrows, R. (2010) Association of caveolin-1 gene polymorphism with kidney transplant fibrosis and allograft failure. JAMA - Journal of the American Medical Association, 303 (13). pp. 1282-1287. ISSN 0098-7484

Moore, Jason and McKnight, Amy Jayne and Döhler, Bernd and Simmonds, Matthew J. and Courtney, Aisling E. and Brand, Oliver J. and Briggs, David and Ball, Simon and Cockwell, Paul and Patterson, Christopher C. and Maxwell, Alexander P. and Gough, Stephen C. L. and Opelz, Gerhard and Borrows, Richard (2012) Donor ABCB1 variant associates with increased risk for kidney allograft failure. Journal of the American Society of Nephrology, 23 (11). pp. 1891-1899. ISSN 1046-6673

Simmonds, M. J. and Howson, J. M. M. and Heward, J. M. and Carr-Smith, J. and Franklyn, J. A. and Todd, J. A. and Gough, S. C. L. (2007) A novel and major association of HLA-C in Graves' disease that eclipses the classical HLA-DRB1 effect. Human Molecular Genetics, 16 (18). pp. 2149-2153. ISSN 0964-6906

Simmonds, Matthew J. and Benavente, David and Brand, Oliver J. and Moore, Jason and Ball, Simon and Ferro, Charles J. and Briggs, David and Gough, Stephen C. L. and Borrows, Richard J. (2013) Skewing of female X-chromosome inactivation: an epigenetic risk factor for kidney transplantation outcome. Transplantation, 95 (5). e25-e28. ISSN 0041-1337

Simmonds, Matthew J. and Heward, Joanne M. and Kelly, M. Ann and Allahabadia, Amit and Foxall, Helen and Gordon, Caroline and Franklyn, Jayne A. and Gough, Stephen C. L. (2002) A nonsense mutation in exon 2 of the DNase I gene is not present in UK subjects with systemic lupus erythematosus and Graves' disease: Comment on the article by Rood et al. Arthritis and Rheumatism, 46 (11). pp. 3109-3110. ISSN 0004-3591

Zeitlin, A. A. and Heward, J. M. and Brand, O. J. and Newby, P. R. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2006) Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. Clinical Endocrinology, 65 (3). pp. 380-384. ISSN 0300-0664

fibroblast

Simmonds, M. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. (2005) The CD40 Kozak SNP: a new susceptibility loci for Graves' disease? Clinical Endocrinology, 63 (2). pp. 232-233. ISSN 0300 0664

fibrosis

Moore, J. and McKnight, A.J. and Simmonds, M. J. and Courtney, A. E. and Hanvesakul, R. and Brand, O. J. and Briggs, D. and Ball, S. and Cockwell, P. and Patterson, C.C. and Maxwell, A. P. and Gough, S. C. L. and Borrows, R. (2010) Association of caveolin-1 gene polymorphism with kidney transplant fibrosis and allograft failure. JAMA - Journal of the American Medical Association, 303 (13). pp. 1282-1287. ISSN 0098-7484

follow up

Moore, J. and McKnight, A.J. and Simmonds, M. J. and Courtney, A. E. and Hanvesakul, R. and Brand, O. J. and Briggs, D. and Ball, S. and Cockwell, P. and Patterson, C.C. and Maxwell, A. P. and Gough, S. C. L. and Borrows, R. (2010) Association of caveolin-1 gene polymorphism with kidney transplant fibrosis and allograft failure. JAMA - Journal of the American Medical Association, 303 (13). pp. 1282-1287. ISSN 0098-7484

Newby, Paul R. and Pickles, Oliver J. and Mazumdar, Samaresh and Brand, Oliver J. and Carr-Smith, Jacqueline D. and Pearce, Simon H. S. and Franklyn, Jayne A. and Evans, David M. and Simmonds, Matthew J. and Gough, Stephen C. L. and Welcome Trust Case-Control Consortium (WTCCC), . (2010) Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study. European Journal of Human Genetics, 18 (9). pp. 1021-1026. ISSN 1018-4813

Simmonds, Matthew J. and Benavente, David and Brand, Oliver J. and Moore, Jason and Ball, Simon and Ferro, Charles J. and Briggs, David and Gough, Stephen C. L. and Borrows, Richard J. (2013) Skewing of female X-chromosome inactivation: an epigenetic risk factor for kidney transplantation outcome. Transplantation, 95 (5). e25-e28. ISSN 0041-1337

gastritis

Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN 1553-7390

gender

Chand, S. and Chue, C. D. and Edwards, N. C. and Hodson, J. and Simmonds, M. J. and Hamilton, A. and Gough, S. C. L. and Harper, L. and Steeds, R. P. and Townend, J. N. and Ferro, C. J. and Borrows, R. (2015) Endothelial nitric oxide synthase single nucleotide polymorphism and left ventricular function in early chronic kidney disease. PLoS ONE, 10 (1). ISSN 1932-6203

gender identity

Elmrghni, Samir and Shaw, Michael and Ali, Nadir and Dixon, Ron and Ross Williams, D. (2012) Aberrations of human gender identification by amelogenin test in Libyans (Benghazi city). Indian Journal of Forensic Medicine and Toxicology, 6 (2). pp. 163-166. ISSN 0973-9122

gender variance

Davy, Zowie (2012) Differences in sexual development: towards a phenomenological understanding of gender variance. In: Controversies and Confrontations: Violence and Agency, 6-7 December 2012, University of Vienna, Austria.

gene

Hunt, K. A. and Smyth, D. J. and Balschun, T. and Ban, M. and Mistry, V. and Ahmed, T. and Barrett, J. C. and Bhaw-Rosun, L. and Bockett, N. A. and Brand, O. J. and Brouwer, E. and Concannon, P. and Cooper, J. D. and Dias, K-R. M. and van Diemen, C. C. and Dubois, P.C. and Edkins, S. and Fölster-Holst, R. and Fransen, K. and Glass, D. N. and Heap, G. A. R. and Hofmann, S. and Huizinga, T. W. J. and Hunt, S. and Langford, C. and Lee, J. and Mansfield, J. and Giovanna Marrosu, M. and Mathew, C. G. and Mein, C.A. and Müller-Quernheim, J. and Nutland, S. and Onengut-Gumuscu, S. and Ouwehand, W. and Pearce, K. and Prescott, N. and Posthumus, M. D. and Potter, S. and Rosati, G. and Sambrook, J. and Satsangi, J. and Schreiber, S. and Shtir, C. and Simmonds, M. J. and Sudman, M. and Thompson, S. D. and Toes, R. and Trynka, G. and Vyse, T. J. and Walker, N. M. and Weidinger, S. and Zhernakova, A. and Zoledziewska, M. and Weersma, R.K. and Gough, S.C.L. and Sawcer, S. and Wijmenga, C. and Parkes, M. and Cucca, F. and Franke, A. and Deloukas, P. and Rich, S. S. and Todd, J. A. and van Heel, D. A. (2011) Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry. Nature Genetics, 44 (1). pp. 3-5. ISSN 10614036

Medici, M. and Porcu, E. and Pistis, G. and Teumer, A. and Brown, S. J. and Jensen, R. A. and Rawal, R. and Roef, G. L. and Plantinga, T. S. and Vermeulen, S. H. and Lahti, J. and Simmonds, M. J. and Husemoen, L. N. N. and Freathy, R. M. and Shields, B. M. and Pietzner, D. and Nagy, R. and Broer, L. and Chaker, L. and Korevaar, T. I. M. and Plia, M. G. and Sala, C. and Volker, U. and Richards, J. B. and Sweep, F. C. and Gieger, C. and Corre, T. and Kajantie, E. and Thuesen, B. and Taes, Y. E. and Visser, W. E. and Hattersley, A. T. and Kratzsch, J. and Hamilton, A. and Li, W. and Homuth, G. and Lobina, M. and Mariotti, S. and Soranzo, N. and Cocca, M. and Nauck, M. and Spielhagen, C. and Ross, A. and Arnold, A. and van de Bunt, M. and Liyanarachchi, S. and Heier, M. and Grabe, H. J. and Masciullo, C. and Galesloot, T. E. and Lim, E. M. and Reischl, E. and Leedman, P. J. and Lai, S. and Delitala, A. and Bremner, A. P. and Philips, D. I. W. and Beilby, J. P. and Mulas, A. and Vocale, M. and Abecasis, G. and Forsen, T. and James, A. and Widen, E. and Hui, J. and Prokisch, H. and Rietzschel, E. E. and Palotie, A. and Feddema, P. and Fletcher, S. J. and Schramm, K. and Rotter, J. I. and Kluttig, A. and Radke, D. and Traglia, M. and Surdulescu, G. L. and He, H. and Franklyn, J. A. and Tiller, D. and Vaidya, B. and de Meyer, T. and Jørgensen, T. and Eriksson, J. G. and O’Leary, P. C. and Wichmann, E. and Hermus, A. R. and Psaty, B. M. and Ittermann, T. and Hofman, A. and Bosi, E. and Schlessinger, D. and Wallaschofski, H. and Pirastu, N. and Aulchenko, Y.S. and de la Chapelle, A. and Netea-Maier, R.T. and Gough, S.C.L. and Meyer zu Schwabedissen, H. and Frayling, T.M. and Kaufman, J.M. and Linneberg, A. and Raikkonen, K. and Smit, J.W.A. and Kiemeney, L.A. and Rivadeneira, F. and Uitterlinden, A.G. and Walsh, J.P. and Meisinger, C. and den Heijer, M. and Visser, T.J. and Spector, T.D. and Wilson, S.G. and Volzke, H. and Cappola, A. and Toniolo, D. and Sanna, S. and Naitza, S. and Peeters, R.P. (2014) Identification of novel genetic loci associated with thyroid peroxidase antibodies and clinical thyroid disease. PLoS Genetics, 10 (2). ISSN 15537390

Moore, Jason and McKnight, Amy Jayne and Döhler, Bernd and Simmonds, Matthew J. and Courtney, Aisling E. and Brand, Oliver J. and Briggs, David and Ball, Simon and Cockwell, Paul and Patterson, Christopher C. and Maxwell, Alexander P. and Gough, Stephen C. L. and Opelz, Gerhard and Borrows, Richard (2012) Donor ABCB1 variant associates with increased risk for kidney allograft failure. Journal of the American Society of Nephrology, 23 (11). pp. 1891-1899. ISSN 1046-6673

Newby, P. R. and Roberts-Davies, E. L. and Brand, O. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2007) Tag SNP screening of the PDCD1 gene for association with Graves' disease. Clinical Endocrinology, 67 (1). pp. 125-128. ISSN 0300-0664

Newby, Paul R. and Pickles, Oliver J. and Mazumdar, Samaresh and Brand, Oliver J. and Carr-Smith, Jacqueline D. and Pearce, Simon H. S. and Franklyn, Jayne A. and Evans, David M. and Simmonds, Matthew J. and Gough, Stephen C. L. and Welcome Trust Case-Control Consortium (WTCCC), . (2010) Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study. European Journal of Human Genetics, 18 (9). pp. 1021-1026. ISSN 1018-4813

Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN 1553-7390

Simmonds, M. J. and Heward, J. M. and Barrett, J. C. and Franklyn, J. A. and Gough, S. C. L. (2006) Association of the BTNL2 rs2076530 single nucleotide polymorphism with Graves' disease appears to be secondary to DRB1 exon 2 position beta74. Clinical Endocrinology, 65 (4). pp. 429-432. ISSN 0300-0664

Simmonds, Matthew J. and Brand, Oliver J. and Barrett, Jeffrey C. and Newby, Paul R. and Franklyn, Jayne A. and Gough, Stephen C. L. (2010) Association of Fc receptor-like 5 (FCRL5) with Graves' disease is secondary to the effect of FCRL3. Clinical Endocrinology, 73 (5). pp. 654-660. ISSN 0300-0664

Zeitlin, A. and Simmonds, M. J. and Gough, S. C. (2008) Genetic developments in autoimmune thyroid disease: an evolutionary process. Clinical Endocrinology, 68 (5). pp. 671-682. ISSN 0300-0664

Zeitlin, A. A. and Heward, J. M. and Brand, O. J. and Newby, P. R. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2006) Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. Clinical Endocrinology, 65 (3). pp. 380-384. ISSN 0300-0664

gene control

Simmonds, Matthew J. (2013) GWAS in autoimmune thyroid disease: redefining our understanding of pathogenesis. Nature Reviews Endocrinology, 9 (5). pp. 277-287. ISSN 1759-5029

gene expression

Brand, O. J. and Barrett, J. C. and Simmonds, M. J. and Newby, P. R. and McCabe, C. J. and Bruce, C. K. and Kysela, B. and Carr-Smith, J. D. and Brix, T. and Hunt, P. J. and Wiersinga, W. M. and Hegedus, L. and Connell, J. and Wass, J. A. H. and Franklyn, J. A. and Weetman, A. P. and Heward, J. M. and Gough, S. C. L. (2009) Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves' disease. Human Molecular Genetics, 18 (9). pp. 1704-1713. ISSN 0964-6906

gene frequency

Cooper, J. D. and Simmonds, M. J. and Walker, N.M. and Burren, O. and Brand, O.J. and Guo, H. and Wallace, C. and Stevens, H. and Coleman, G and Franklyn, J.A. and Todd, J.A. and Gough, S.C.L. (2012) Seven newly identified loci for autoimmune thyroid disease. Human Molecular Genetics, 21 (23). pp. 5202-5208. ISSN 0964-6906

Hunt, K. A. and Smyth, D. J. and Balschun, T. and Ban, M. and Mistry, V. and Ahmed, T. and Barrett, J. C. and Bhaw-Rosun, L. and Bockett, N. A. and Brand, O. J. and Brouwer, E. and Concannon, P. and Cooper, J. D. and Dias, K-R. M. and van Diemen, C. C. and Dubois, P.C. and Edkins, S. and Fölster-Holst, R. and Fransen, K. and Glass, D. N. and Heap, G. A. R. and Hofmann, S. and Huizinga, T. W. J. and Hunt, S. and Langford, C. and Lee, J. and Mansfield, J. and Giovanna Marrosu, M. and Mathew, C. G. and Mein, C.A. and Müller-Quernheim, J. and Nutland, S. and Onengut-Gumuscu, S. and Ouwehand, W. and Pearce, K. and Prescott, N. and Posthumus, M. D. and Potter, S. and Rosati, G. and Sambrook, J. and Satsangi, J. and Schreiber, S. and Shtir, C. and Simmonds, M. J. and Sudman, M. and Thompson, S. D. and Toes, R. and Trynka, G. and Vyse, T. J. and Walker, N. M. and Weidinger, S. and Zhernakova, A. and Zoledziewska, M. and Weersma, R.K. and Gough, S.C.L. and Sawcer, S. and Wijmenga, C. and Parkes, M. and Cucca, F. and Franke, A. and Deloukas, P. and Rich, S. S. and Todd, J. A. and van Heel, D. A. (2011) Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry. Nature Genetics, 44 (1). pp. 3-5. ISSN 10614036

Medici, M. and Porcu, E. and Pistis, G. and Teumer, A. and Brown, S. J. and Jensen, R. A. and Rawal, R. and Roef, G. L. and Plantinga, T. S. and Vermeulen, S. H. and Lahti, J. and Simmonds, M. J. and Husemoen, L. N. N. and Freathy, R. M. and Shields, B. M. and Pietzner, D. and Nagy, R. and Broer, L. and Chaker, L. and Korevaar, T. I. M. and Plia, M. G. and Sala, C. and Volker, U. and Richards, J. B. and Sweep, F. C. and Gieger, C. and Corre, T. and Kajantie, E. and Thuesen, B. and Taes, Y. E. and Visser, W. E. and Hattersley, A. T. and Kratzsch, J. and Hamilton, A. and Li, W. and Homuth, G. and Lobina, M. and Mariotti, S. and Soranzo, N. and Cocca, M. and Nauck, M. and Spielhagen, C. and Ross, A. and Arnold, A. and van de Bunt, M. and Liyanarachchi, S. and Heier, M. and Grabe, H. J. and Masciullo, C. and Galesloot, T. E. and Lim, E. M. and Reischl, E. and Leedman, P. J. and Lai, S. and Delitala, A. and Bremner, A. P. and Philips, D. I. W. and Beilby, J. P. and Mulas, A. and Vocale, M. and Abecasis, G. and Forsen, T. and James, A. and Widen, E. and Hui, J. and Prokisch, H. and Rietzschel, E. E. and Palotie, A. and Feddema, P. and Fletcher, S. J. and Schramm, K. and Rotter, J. I. and Kluttig, A. and Radke, D. and Traglia, M. and Surdulescu, G. L. and He, H. and Franklyn, J. A. and Tiller, D. and Vaidya, B. and de Meyer, T. and Jørgensen, T. and Eriksson, J. G. and O’Leary, P. C. and Wichmann, E. and Hermus, A. R. and Psaty, B. M. and Ittermann, T. and Hofman, A. and Bosi, E. and Schlessinger, D. and Wallaschofski, H. and Pirastu, N. and Aulchenko, Y.S. and de la Chapelle, A. and Netea-Maier, R.T. and Gough, S.C.L. and Meyer zu Schwabedissen, H. and Frayling, T.M. and Kaufman, J.M. and Linneberg, A. and Raikkonen, K. and Smit, J.W.A. and Kiemeney, L.A. and Rivadeneira, F. and Uitterlinden, A.G. and Walsh, J.P. and Meisinger, C. and den Heijer, M. and Visser, T.J. and Spector, T.D. and Wilson, S.G. and Volzke, H. and Cappola, A. and Toniolo, D. and Sanna, S. and Naitza, S. and Peeters, R.P. (2014) Identification of novel genetic loci associated with thyroid peroxidase antibodies and clinical thyroid disease. PLoS Genetics, 10 (2). ISSN 15537390

Newby, Paul R. and Pickles, Oliver J. and Mazumdar, Samaresh and Brand, Oliver J. and Carr-Smith, Jacqueline D. and Pearce, Simon H. S. and Franklyn, Jayne A. and Evans, David M. and Simmonds, Matthew J. and Gough, Stephen C. L. and Welcome Trust Case-Control Consortium (WTCCC), . (2010) Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study. European Journal of Human Genetics, 18 (9). pp. 1021-1026. ISSN 1018-4813

Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN 1553-7390

Simmonds, M. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. (2005) The CD40 Kozak SNP: a new susceptibility loci for Graves' disease? Clinical Endocrinology, 63 (2). pp. 232-233. ISSN 0300 0664

Simmonds, M. J. and Heward, J.M. and Howson, J.M.M. and Foxall, H. and Nithiyananthan, R. and Franklyn, J.A. and Gough, S.C.L. (2004) A systematic approach to the assesment of known TNF-alpha polymorphisms in Graves' disease. Genes and Immunity, 5 (4). pp. 267-273. ISSN 1466-4879

Simmonds, M. J. and Howson, J. M. M. and Heward, J. M. and Carr-Smith, J. and Franklyn, J. A. and Todd, J. A. and Gough, S. C. L. (2007) A novel and major association of HLA-C in Graves' disease that eclipses the classical HLA-DRB1 effect. Human Molecular Genetics, 16 (18). pp. 2149-2153. ISSN 0964-6906

Simmonds, Matthew J. and Gough, Stephen C. L. (2011) The search for the genetic contribution to autoimmune thyroid disease: The never ending story? Briefings in Functional Genomics, 10 (2). pp. 77-90. ISSN 2041-2649

Yesmin, K. and Hargreaves, C. and Newby, P. R. and Brand, O. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2010) Association of FcGRIIa with Graves' disease: a potential role for dysregulated autoantibody clearance in disease onset/progression. Clinical Endocrinology, 73 (1). pp. 119-125. ISSN 0300-0664

Zeitlin, A. A. and Heward, J. M. and Newby, P. R. and Carr-Smith, J. D. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2008) Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. Genes and Immunity, 9 (4). pp. 358-363. ISSN 1466-4879

gene function

Brand, O. J. and Barrett, J. C. and Simmonds, M. J. and Newby, P. R. and McCabe, C. J. and Bruce, C. K. and Kysela, B. and Carr-Smith, J. D. and Brix, T. and Hunt, P. J. and Wiersinga, W. M. and Hegedus, L. and Connell, J. and Wass, J. A. H. and Franklyn, J. A. and Weetman, A. P. and Heward, J. M. and Gough, S. C. L. (2009) Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves' disease. Human Molecular Genetics, 18 (9). pp. 1704-1713. ISSN 0964-6906

Simmonds, Matthew and Gough, S. C. L. (2005) Genetic insights into disease mechanisms of autoimmunity. British Medical Bulletin, 71 (1). pp. 93-113. ISSN 0007-1420

gene identification

Medici, M. and Porcu, E. and Pistis, G. and Teumer, A. and Brown, S. J. and Jensen, R. A. and Rawal, R. and Roef, G. L. and Plantinga, T. S. and Vermeulen, S. H. and Lahti, J. and Simmonds, M. J. and Husemoen, L. N. N. and Freathy, R. M. and Shields, B. M. and Pietzner, D. and Nagy, R. and Broer, L. and Chaker, L. and Korevaar, T. I. M. and Plia, M. G. and Sala, C. and Volker, U. and Richards, J. B. and Sweep, F. C. and Gieger, C. and Corre, T. and Kajantie, E. and Thuesen, B. and Taes, Y. E. and Visser, W. E. and Hattersley, A. T. and Kratzsch, J. and Hamilton, A. and Li, W. and Homuth, G. and Lobina, M. and Mariotti, S. and Soranzo, N. and Cocca, M. and Nauck, M. and Spielhagen, C. and Ross, A. and Arnold, A. and van de Bunt, M. and Liyanarachchi, S. and Heier, M. and Grabe, H. J. and Masciullo, C. and Galesloot, T. E. and Lim, E. M. and Reischl, E. and Leedman, P. J. and Lai, S. and Delitala, A. and Bremner, A. P. and Philips, D. I. W. and Beilby, J. P. and Mulas, A. and Vocale, M. and Abecasis, G. and Forsen, T. and James, A. and Widen, E. and Hui, J. and Prokisch, H. and Rietzschel, E. E. and Palotie, A. and Feddema, P. and Fletcher, S. J. and Schramm, K. and Rotter, J. I. and Kluttig, A. and Radke, D. and Traglia, M. and Surdulescu, G. L. and He, H. and Franklyn, J. A. and Tiller, D. and Vaidya, B. and de Meyer, T. and Jørgensen, T. and Eriksson, J. G. and O’Leary, P. C. and Wichmann, E. and Hermus, A. R. and Psaty, B. M. and Ittermann, T. and Hofman, A. and Bosi, E. and Schlessinger, D. and Wallaschofski, H. and Pirastu, N. and Aulchenko, Y.S. and de la Chapelle, A. and Netea-Maier, R.T. and Gough, S.C.L. and Meyer zu Schwabedissen, H. and Frayling, T.M. and Kaufman, J.M. and Linneberg, A. and Raikkonen, K. and Smit, J.W.A. and Kiemeney, L.A. and Rivadeneira, F. and Uitterlinden, A.G. and Walsh, J.P. and Meisinger, C. and den Heijer, M. and Visser, T.J. and Spector, T.D. and Wilson, S.G. and Volzke, H. and Cappola, A. and Toniolo, D. and Sanna, S. and Naitza, S. and Peeters, R.P. (2014) Identification of novel genetic loci associated with thyroid peroxidase antibodies and clinical thyroid disease. PLoS Genetics, 10 (2). ISSN 15537390

Newby, Paul R. and Pickles, Oliver J. and Mazumdar, Samaresh and Brand, Oliver J. and Carr-Smith, Jacqueline D. and Pearce, Simon H. S. and Franklyn, Jayne A. and Evans, David M. and Simmonds, Matthew J. and Gough, Stephen C. L. and Welcome Trust Case-Control Consortium (WTCCC), . (2010) Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study. European Journal of Human Genetics, 18 (9). pp. 1021-1026. ISSN 1018-4813

Simmonds, Matthew J. and Gough, Stephen C. L. (2011) The search for the genetic contribution to autoimmune thyroid disease: The never ending story? Briefings in Functional Genomics, 10 (2). pp. 77-90. ISSN 2041-2649

Zeitlin, A. and Simmonds, M. J. and Gough, S. C. (2008) Genetic developments in autoimmune thyroid disease: an evolutionary process. Clinical Endocrinology, 68 (5). pp. 671-682. ISSN 0300-0664

gene interaction

Simmonds, Matthew J. and Gough, Stephen C. L. (2011) The search for the genetic contribution to autoimmune thyroid disease: The never ending story? Briefings in Functional Genomics, 10 (2). pp. 77-90. ISSN 2041-2649

gene linkage disequilibrium

Brand, O. J. and Barrett, J. C. and Simmonds, M. J. and Newby, P. R. and McCabe, C. J. and Bruce, C. K. and Kysela, B. and Carr-Smith, J. D. and Brix, T. and Hunt, P. J. and Wiersinga, W. M. and Hegedus, L. and Connell, J. and Wass, J. A. H. and Franklyn, J. A. and Weetman, A. P. and Heward, J. M. and Gough, S. C. L. (2009) Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves' disease. Human Molecular Genetics, 18 (9). pp. 1704-1713. ISSN 0964-6906

Gough, S .C. L. and Simmonds, Matthew J. (2007) The HLA region and autoimmune disease: associations and mechanisms of action. Current Genomics, 8 (7). pp. 453-465. ISSN 1389-2029

Hunt, K. A. and Mistry, V. and Bockett, N. A. and Ahmad, T. and Ban, M. and Barker, J. N. and Barrett, J. C. and Blackburn, H. and Brand, O. J. and Burren, O. and Capon, F. and Compston, A. and Gough, S. C. L. and Jostins, L. and Kong, Y. and Lee, J. C. and Lek, M. and MacArthur, D. G. and Mansfield, J. C. and Mathew, C. G. and Mein, C. A. and Mirza, M. and Nutland, S. and Onengut-Gumuscu, S. and Papouli, E. and Parkes, M. and Rich, S. S. and Sawcer, S. and Satsangi, J. and Simmonds, M. J. and Trembath, R. C. and Walker, N. M. and Wozniak, E. and Todd, J. A. and Simpson, M. A. and Plagnol, V. and van Heel, D. A. (2013) Negligible impact of rare autoimmune-locus coding-region variants on missing heritability. Nature, 498 (7453). pp. 232-235. ISSN 0028-0836

Moore, Jason and McKnight, Amy Jayne and Döhler, Bernd and Simmonds, Matthew J. and Courtney, Aisling E. and Brand, Oliver J. and Briggs, David and Ball, Simon and Cockwell, Paul and Patterson, Christopher C. and Maxwell, Alexander P. and Gough, Stephen C. L. and Opelz, Gerhard and Borrows, Richard (2012) Donor ABCB1 variant associates with increased risk for kidney allograft failure. Journal of the American Society of Nephrology, 23 (11). pp. 1891-1899. ISSN 1046-6673

Simmonds, M. J. and Heward, J.M. and Howson, J.M.M. and Foxall, H. and Nithiyananthan, R. and Franklyn, J.A. and Gough, S.C.L. (2004) A systematic approach to the assesment of known TNF-alpha polymorphisms in Graves' disease. Genes and Immunity, 5 (4). pp. 267-273. ISSN 1466-4879

Simmonds, M. J. and Howson, J. M. M. and Heward, J. M. and Carr-Smith, J. and Franklyn, J. A. and Todd, J. A. and Gough, S. C. L. (2007) A novel and major association of HLA-C in Graves' disease that eclipses the classical HLA-DRB1 effect. Human Molecular Genetics, 16 (18). pp. 2149-2153. ISSN 0964-6906

Simmonds, Matthew J. and Brand, Oliver J. and Barrett, Jeffrey C. and Newby, Paul R. and Franklyn, Jayne A. and Gough, Stephen C. L. (2010) Association of Fc receptor-like 5 (FCRL5) with Graves' disease is secondary to the effect of FCRL3. Clinical Endocrinology, 73 (5). pp. 654-660. ISSN 0300-0664

Simmonds, Matthew J. and Howson, Joanna M. M. and Heward, Joanne M. and Cordell, Heather J. and Foxall, Helen and Carr-Smith, Jackie and Gibson, Sarah M. and Walker, Neil and Tomer, Yaron and Franklyn, Jayne A. and Todd, John A. and Gough, Stephen C. L. (2005) Regression mapping of association between the human leukocyte antigen region and Graves' disease. American Journal of Human Genetics, 76 (1). pp. 157-163. ISSN 0002-9297

gene location

Simmonds, Matthew J. and Heward, J. M. and Carr-Smith, J. and Foxall, H. and Franklyn, J. A. and Gough, S. C. L. (2006) Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease. Journal of Clinical Endocrinology and Metabolism, 91 (3). pp. 1056-1061. ISSN 0021-972X

gene locus

Brand, O. J. and Barrett, J. C. and Simmonds, M. J. and Newby, P. R. and McCabe, C. J. and Bruce, C. K. and Kysela, B. and Carr-Smith, J. D. and Brix, T. and Hunt, P. J. and Wiersinga, W. M. and Hegedus, L. and Connell, J. and Wass, J. A. H. and Franklyn, J. A. and Weetman, A. P. and Heward, J. M. and Gough, S. C. L. (2009) Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves' disease. Human Molecular Genetics, 18 (9). pp. 1704-1713. ISSN 0964-6906

Cooper, J. D. and Simmonds, M. J. and Walker, N.M. and Burren, O. and Brand, O.J. and Guo, H. and Wallace, C. and Stevens, H. and Coleman, G and Franklyn, J.A. and Todd, J.A. and Gough, S.C.L. (2012) Seven newly identified loci for autoimmune thyroid disease. Human Molecular Genetics, 21 (23). pp. 5202-5208. ISSN 0964-6906

Hunt, K. A. and Mistry, V. and Bockett, N. A. and Ahmad, T. and Ban, M. and Barker, J. N. and Barrett, J. C. and Blackburn, H. and Brand, O. J. and Burren, O. and Capon, F. and Compston, A. and Gough, S. C. L. and Jostins, L. and Kong, Y. and Lee, J. C. and Lek, M. and MacArthur, D. G. and Mansfield, J. C. and Mathew, C. G. and Mein, C. A. and Mirza, M. and Nutland, S. and Onengut-Gumuscu, S. and Papouli, E. and Parkes, M. and Rich, S. S. and Sawcer, S. and Satsangi, J. and Simmonds, M. J. and Trembath, R. C. and Walker, N. M. and Wozniak, E. and Todd, J. A. and Simpson, M. A. and Plagnol, V. and van Heel, D. A. (2013) Negligible impact of rare autoimmune-locus coding-region variants on missing heritability. Nature, 498 (7453). pp. 232-235. ISSN 0028-0836

Medici, M. and Porcu, E. and Pistis, G. and Teumer, A. and Brown, S. J. and Jensen, R. A. and Rawal, R. and Roef, G. L. and Plantinga, T. S. and Vermeulen, S. H. and Lahti, J. and Simmonds, M. J. and Husemoen, L. N. N. and Freathy, R. M. and Shields, B. M. and Pietzner, D. and Nagy, R. and Broer, L. and Chaker, L. and Korevaar, T. I. M. and Plia, M. G. and Sala, C. and Volker, U. and Richards, J. B. and Sweep, F. C. and Gieger, C. and Corre, T. and Kajantie, E. and Thuesen, B. and Taes, Y. E. and Visser, W. E. and Hattersley, A. T. and Kratzsch, J. and Hamilton, A. and Li, W. and Homuth, G. and Lobina, M. and Mariotti, S. and Soranzo, N. and Cocca, M. and Nauck, M. and Spielhagen, C. and Ross, A. and Arnold, A. and van de Bunt, M. and Liyanarachchi, S. and Heier, M. and Grabe, H. J. and Masciullo, C. and Galesloot, T. E. and Lim, E. M. and Reischl, E. and Leedman, P. J. and Lai, S. and Delitala, A. and Bremner, A. P. and Philips, D. I. W. and Beilby, J. P. and Mulas, A. and Vocale, M. and Abecasis, G. and Forsen, T. and James, A. and Widen, E. and Hui, J. and Prokisch, H. and Rietzschel, E. E. and Palotie, A. and Feddema, P. and Fletcher, S. J. and Schramm, K. and Rotter, J. I. and Kluttig, A. and Radke, D. and Traglia, M. and Surdulescu, G. L. and He, H. and Franklyn, J. A. and Tiller, D. and Vaidya, B. and de Meyer, T. and Jørgensen, T. and Eriksson, J. G. and O’Leary, P. C. and Wichmann, E. and Hermus, A. R. and Psaty, B. M. and Ittermann, T. and Hofman, A. and Bosi, E. and Schlessinger, D. and Wallaschofski, H. and Pirastu, N. and Aulchenko, Y.S. and de la Chapelle, A. and Netea-Maier, R.T. and Gough, S.C.L. and Meyer zu Schwabedissen, H. and Frayling, T.M. and Kaufman, J.M. and Linneberg, A. and Raikkonen, K. and Smit, J.W.A. and Kiemeney, L.A. and Rivadeneira, F. and Uitterlinden, A.G. and Walsh, J.P. and Meisinger, C. and den Heijer, M. and Visser, T.J. and Spector, T.D. and Wilson, S.G. and Volzke, H. and Cappola, A. and Toniolo, D. and Sanna, S. and Naitza, S. and Peeters, R.P. (2014) Identification of novel genetic loci associated with thyroid peroxidase antibodies and clinical thyroid disease. PLoS Genetics, 10 (2). ISSN 15537390

Newby, Paul R. and Pickles, Oliver J. and Mazumdar, Samaresh and Brand, Oliver J. and Carr-Smith, Jacqueline D. and Pearce, Simon H. S. and Franklyn, Jayne A. and Evans, David M. and Simmonds, Matthew J. and Gough, Stephen C. L. and Welcome Trust Case-Control Consortium (WTCCC), . (2010) Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study. European Journal of Human Genetics, 18 (9). pp. 1021-1026. ISSN 1018-4813

Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN 1553-7390

Simmonds, M. J. and Gough, S. C. L. (2004) Unravelling the genetic complexity of autoimmune thyroid disease: HLA, CTLA-4 and beyond. Clinical and Experimental Immunology, 136 (1). pp. 1-10. ISSN 0009-9104

Simmonds, M. J. and Heward, J. M. and Barrett, J. C. and Franklyn, J. A. and Gough, S. C. L. (2006) Association of the BTNL2 rs2076530 single nucleotide polymorphism with Graves' disease appears to be secondary to DRB1 exon 2 position beta74. Clinical Endocrinology, 65 (4). pp. 429-432. ISSN 0300-0664

Simmonds, M. J. and Howson, J. M. M. and Heward, J. M. and Carr-Smith, J. and Franklyn, J. A. and Todd, J. A. and Gough, S. C. L. (2007) A novel and major association of HLA-C in Graves' disease that eclipses the classical HLA-DRB1 effect. Human Molecular Genetics, 16 (18). pp. 2149-2153. ISSN 0964-6906

Simmonds, Matthew J. (2013) GWAS in autoimmune thyroid disease: redefining our understanding of pathogenesis. Nature Reviews Endocrinology, 9 (5). pp. 277-287. ISSN 1759-5029

Todd, J. A. and Walker, N. M. and Cooper, J. D. and Smyth, D. J. and Downes, K. and Plagnol, V. and Bailey, R. and Nejentsev, S. and Field, S. F. and Payne, F. and Lowe, C. E. and Szeszko, J. S. and Hafler, J. P. and Zeitels, L. and Yang, J. H. M. and Vella, A. and Nutland, S. and Stevens, H. E. and Schuilenburg, H. and Coleman, G. and Maisuria, M. and Meadows, W. and Smink, L. J. and Healy, B. and Burren, O. S. and Lam, A. A. C. and Ovington, N. R. and Allen, J. and Adlem, E. and Leung, H-T. and Wallace, C. and Howson, J. M. M. and Guja, C. and Ionescu-Tırgoviste, C. and Genetics of T1D in Finland, . and Simmonds, M. J. and Heward, J. M. and Gough, S. C. L. and WTCCC, . and Dunger, D. B. and Wicker, L. S. and Clayton, D. G. (2007) Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nature Genetics, 39 (7). pp. 857-864. ISSN 1061-4036

Zeitlin, A. and Simmonds, M. J. and Gough, S. C. (2008) Genetic developments in autoimmune thyroid disease: an evolutionary process. Clinical Endocrinology, 68 (5). pp. 671-682. ISSN 0300-0664

Zeitlin, A. A. and Heward, J. M. and Brand, O. J. and Newby, P. R. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2006) Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. Clinical Endocrinology, 65 (3). pp. 380-384. ISSN 0300-0664

Zeitlin, A. A. and Heward, J. M. and Newby, P. R. and Carr-Smith, J. D. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2008) Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. Genes and Immunity, 9 (4). pp. 358-363. ISSN 1466-4879

gene mapping

Hafler, J. P. and Maier, L. M. and Cooper, J. D. and Plagnol, V. and Hinks, A. and Simmonds, M. J. and Stevens, H. and Walker, N. and Healy, B. and Howson, J. M. M. and Maisuria, M. and Duley, S. and Coleman, G. and Gough, S. C. L. and Worthington, J. and Kuchroo, V. K. and Wicker, L. S. and Todd, J. A. and IMSGC, . (2009) CD226 Gly307Ser association with multiple autoimmune diseases. Genes and Immunity, 10 (1). pp. 5-10. ISSN 1466-4879

Simmonds, M. J. and Gough, S. C. L. (2004) Unravelling the genetic complexity of autoimmune thyroid disease: HLA, CTLA-4 and beyond. Clinical and Experimental Immunology, 136 (1). pp. 1-10. ISSN 0009-9104

Simmonds, M. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. (2005) The CD40 Kozak SNP: a new susceptibility loci for Graves' disease? Clinical Endocrinology, 63 (2). pp. 232-233. ISSN 0300 0664

Simmonds, Matthew J. and Gough, Stephen C. L. (2011) The search for the genetic contribution to autoimmune thyroid disease: The never ending story? Briefings in Functional Genomics, 10 (2). pp. 77-90. ISSN 2041-2649

Simmonds, Matthew J. and Heward, J. M. and Carr-Smith, J. and Foxall, H. and Franklyn, J. A. and Gough, S. C. L. (2006) Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease. Journal of Clinical Endocrinology and Metabolism, 91 (3). pp. 1056-1061. ISSN 0021-972X

Simmonds, Matthew J. and Howson, Joanna M. M. and Heward, Joanne M. and Cordell, Heather J. and Foxall, Helen and Carr-Smith, Jackie and Gibson, Sarah M. and Walker, Neil and Tomer, Yaron and Franklyn, Jayne A. and Todd, John A. and Gough, Stephen C. L. (2005) Regression mapping of association between the human leukocyte antigen region and Graves' disease. American Journal of Human Genetics, 76 (1). pp. 157-163. ISSN 0002-9297

Zeitlin, A. and Simmonds, M. J. and Gough, S. C. (2008) Genetic developments in autoimmune thyroid disease: an evolutionary process. Clinical Endocrinology, 68 (5). pp. 671-682. ISSN 0300-0664

Zeitlin, A. A. and Heward, J. M. and Brand, O. J. and Newby, P. R. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2006) Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. Clinical Endocrinology, 65 (3). pp. 380-384. ISSN 0300-0664

gene replication

Brand, O. J. and Barrett, J. C. and Simmonds, M. J. and Newby, P. R. and McCabe, C. J. and Bruce, C. K. and Kysela, B. and Carr-Smith, J. D. and Brix, T. and Hunt, P. J. and Wiersinga, W. M. and Hegedus, L. and Connell, J. and Wass, J. A. H. and Franklyn, J. A. and Weetman, A. P. and Heward, J. M. and Gough, S. C. L. (2009) Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves' disease. Human Molecular Genetics, 18 (9). pp. 1704-1713. ISSN 0964-6906

Newby, Paul R. and Pickles, Oliver J. and Mazumdar, Samaresh and Brand, Oliver J. and Carr-Smith, Jacqueline D. and Pearce, Simon H. S. and Franklyn, Jayne A. and Evans, David M. and Simmonds, Matthew J. and Gough, Stephen C. L. and Welcome Trust Case-Control Consortium (WTCCC), . (2010) Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study. European Journal of Human Genetics, 18 (9). pp. 1021-1026. ISSN 1018-4813

gene sequence

Hafler, J. P. and Maier, L. M. and Cooper, J. D. and Plagnol, V. and Hinks, A. and Simmonds, M. J. and Stevens, H. and Walker, N. and Healy, B. and Howson, J. M. M. and Maisuria, M. and Duley, S. and Coleman, G. and Gough, S. C. L. and Worthington, J. and Kuchroo, V. K. and Wicker, L. S. and Todd, J. A. and IMSGC, . (2009) CD226 Gly307Ser association with multiple autoimmune diseases. Genes and Immunity, 10 (1). pp. 5-10. ISSN 1466-4879

Simmonds, M. J. and Gough, S. C. L. (2004) Unravelling the genetic complexity of autoimmune thyroid disease: HLA, CTLA-4 and beyond. Clinical and Experimental Immunology, 136 (1). pp. 1-10. ISSN 0009-9104

genetic analysis

Hafler, J. P. and Maier, L. M. and Cooper, J. D. and Plagnol, V. and Hinks, A. and Simmonds, M. J. and Stevens, H. and Walker, N. and Healy, B. and Howson, J. M. M. and Maisuria, M. and Duley, S. and Coleman, G. and Gough, S. C. L. and Worthington, J. and Kuchroo, V. K. and Wicker, L. S. and Todd, J. A. and IMSGC, . (2009) CD226 Gly307Ser association with multiple autoimmune diseases. Genes and Immunity, 10 (1). pp. 5-10. ISSN 1466-4879

Hunt, K. A. and Mistry, V. and Bockett, N. A. and Ahmad, T. and Ban, M. and Barker, J. N. and Barrett, J. C. and Blackburn, H. and Brand, O. J. and Burren, O. and Capon, F. and Compston, A. and Gough, S. C. L. and Jostins, L. and Kong, Y. and Lee, J. C. and Lek, M. and MacArthur, D. G. and Mansfield, J. C. and Mathew, C. G. and Mein, C. A. and Mirza, M. and Nutland, S. and Onengut-Gumuscu, S. and Papouli, E. and Parkes, M. and Rich, S. S. and Sawcer, S. and Satsangi, J. and Simmonds, M. J. and Trembath, R. C. and Walker, N. M. and Wozniak, E. and Todd, J. A. and Simpson, M. A. and Plagnol, V. and van Heel, D. A. (2013) Negligible impact of rare autoimmune-locus coding-region variants on missing heritability. Nature, 498 (7453). pp. 232-235. ISSN 0028-0836

Simmonds, Matthew and Gough, S. C. L. (2005) Genetic insights into disease mechanisms of autoimmunity. British Medical Bulletin, 71 (1). pp. 93-113. ISSN 0007-1420

genetic association

Brand, O. J. and Barrett, J. C. and Simmonds, M. J. and Newby, P. R. and McCabe, C. J. and Bruce, C. K. and Kysela, B. and Carr-Smith, J. D. and Brix, T. and Hunt, P. J. and Wiersinga, W. M. and Hegedus, L. and Connell, J. and Wass, J. A. H. and Franklyn, J. A. and Weetman, A. P. and Heward, J. M. and Gough, S. C. L. (2009) Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves' disease. Human Molecular Genetics, 18 (9). pp. 1704-1713. ISSN 0964-6906

Chand, S. and Holle, J. U. and Hilhorst, M. and Simmonds, M. J. and Smith, S. and Kamesh, L. and Hewins, P. and McKnight, A. J. and Maxwell, A. P. and Willem Cohen Tervaert, J. and Wieczorek, S. and Harper, L. and Borrows, R. (2013) Caveolin-1 single nucleotide polymorphism in antineutrophil cytoplasmic antibody associated vasculitis. PLoS ONE, 8 (7). ISSN 1932-6203

Cooper, J. D. and Simmonds, M. J. and Walker, N.M. and Burren, O. and Brand, O.J. and Guo, H. and Wallace, C. and Stevens, H. and Coleman, G and Franklyn, J.A. and Todd, J.A. and Gough, S.C.L. (2012) Seven newly identified loci for autoimmune thyroid disease. Human Molecular Genetics, 21 (23). pp. 5202-5208. ISSN 0964-6906

Gough, S .C. L. and Simmonds, Matthew J. (2007) The HLA region and autoimmune disease: associations and mechanisms of action. Current Genomics, 8 (7). pp. 453-465. ISSN 1389-2029

Hafler, J. P. and Maier, L. M. and Cooper, J. D. and Plagnol, V. and Hinks, A. and Simmonds, M. J. and Stevens, H. and Walker, N. and Healy, B. and Howson, J. M. M. and Maisuria, M. and Duley, S. and Coleman, G. and Gough, S. C. L. and Worthington, J. and Kuchroo, V. K. and Wicker, L. S. and Todd, J. A. and IMSGC, . (2009) CD226 Gly307Ser association with multiple autoimmune diseases. Genes and Immunity, 10 (1). pp. 5-10. ISSN 1466-4879

Hunt, K. A. and Mistry, V. and Bockett, N. A. and Ahmad, T. and Ban, M. and Barker, J. N. and Barrett, J. C. and Blackburn, H. and Brand, O. J. and Burren, O. and Capon, F. and Compston, A. and Gough, S. C. L. and Jostins, L. and Kong, Y. and Lee, J. C. and Lek, M. and MacArthur, D. G. and Mansfield, J. C. and Mathew, C. G. and Mein, C. A. and Mirza, M. and Nutland, S. and Onengut-Gumuscu, S. and Papouli, E. and Parkes, M. and Rich, S. S. and Sawcer, S. and Satsangi, J. and Simmonds, M. J. and Trembath, R. C. and Walker, N. M. and Wozniak, E. and Todd, J. A. and Simpson, M. A. and Plagnol, V. and van Heel, D. A. (2013) Negligible impact of rare autoimmune-locus coding-region variants on missing heritability. Nature, 498 (7453). pp. 232-235. ISSN 0028-0836

Hunt, K. A. and Smyth, D. J. and Balschun, T. and Ban, M. and Mistry, V. and Ahmed, T. and Barrett, J. C. and Bhaw-Rosun, L. and Bockett, N. A. and Brand, O. J. and Brouwer, E. and Concannon, P. and Cooper, J. D. and Dias, K-R. M. and van Diemen, C. C. and Dubois, P.C. and Edkins, S. and Fölster-Holst, R. and Fransen, K. and Glass, D. N. and Heap, G. A. R. and Hofmann, S. and Huizinga, T. W. J. and Hunt, S. and Langford, C. and Lee, J. and Mansfield, J. and Giovanna Marrosu, M. and Mathew, C. G. and Mein, C.A. and Müller-Quernheim, J. and Nutland, S. and Onengut-Gumuscu, S. and Ouwehand, W. and Pearce, K. and Prescott, N. and Posthumus, M. D. and Potter, S. and Rosati, G. and Sambrook, J. and Satsangi, J. and Schreiber, S. and Shtir, C. and Simmonds, M. J. and Sudman, M. and Thompson, S. D. and Toes, R. and Trynka, G. and Vyse, T. J. and Walker, N. M. and Weidinger, S. and Zhernakova, A. and Zoledziewska, M. and Weersma, R.K. and Gough, S.C.L. and Sawcer, S. and Wijmenga, C. and Parkes, M. and Cucca, F. and Franke, A. and Deloukas, P. and Rich, S. S. and Todd, J. A. and van Heel, D. A. (2011) Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry. Nature Genetics, 44 (1). pp. 3-5. ISSN 10614036

Medici, M. and Porcu, E. and Pistis, G. and Teumer, A. and Brown, S. J. and Jensen, R. A. and Rawal, R. and Roef, G. L. and Plantinga, T. S. and Vermeulen, S. H. and Lahti, J. and Simmonds, M. J. and Husemoen, L. N. N. and Freathy, R. M. and Shields, B. M. and Pietzner, D. and Nagy, R. and Broer, L. and Chaker, L. and Korevaar, T. I. M. and Plia, M. G. and Sala, C. and Volker, U. and Richards, J. B. and Sweep, F. C. and Gieger, C. and Corre, T. and Kajantie, E. and Thuesen, B. and Taes, Y. E. and Visser, W. E. and Hattersley, A. T. and Kratzsch, J. and Hamilton, A. and Li, W. and Homuth, G. and Lobina, M. and Mariotti, S. and Soranzo, N. and Cocca, M. and Nauck, M. and Spielhagen, C. and Ross, A. and Arnold, A. and van de Bunt, M. and Liyanarachchi, S. and Heier, M. and Grabe, H. J. and Masciullo, C. and Galesloot, T. E. and Lim, E. M. and Reischl, E. and Leedman, P. J. and Lai, S. and Delitala, A. and Bremner, A. P. and Philips, D. I. W. and Beilby, J. P. and Mulas, A. and Vocale, M. and Abecasis, G. and Forsen, T. and James, A. and Widen, E. and Hui, J. and Prokisch, H. and Rietzschel, E. E. and Palotie, A. and Feddema, P. and Fletcher, S. J. and Schramm, K. and Rotter, J. I. and Kluttig, A. and Radke, D. and Traglia, M. and Surdulescu, G. L. and He, H. and Franklyn, J. A. and Tiller, D. and Vaidya, B. and de Meyer, T. and Jørgensen, T. and Eriksson, J. G. and O’Leary, P. C. and Wichmann, E. and Hermus, A. R. and Psaty, B. M. and Ittermann, T. and Hofman, A. and Bosi, E. and Schlessinger, D. and Wallaschofski, H. and Pirastu, N. and Aulchenko, Y.S. and de la Chapelle, A. and Netea-Maier, R.T. and Gough, S.C.L. and Meyer zu Schwabedissen, H. and Frayling, T.M. and Kaufman, J.M. and Linneberg, A. and Raikkonen, K. and Smit, J.W.A. and Kiemeney, L.A. and Rivadeneira, F. and Uitterlinden, A.G. and Walsh, J.P. and Meisinger, C. and den Heijer, M. and Visser, T.J. and Spector, T.D. and Wilson, S.G. and Volzke, H. and Cappola, A. and Toniolo, D. and Sanna, S. and Naitza, S. and Peeters, R.P. (2014) Identification of novel genetic loci associated with thyroid peroxidase antibodies and clinical thyroid disease. PLoS Genetics, 10 (2). ISSN 15537390

Moore, J. and McKnight, A.J. and Simmonds, M. J. and Courtney, A. E. and Hanvesakul, R. and Brand, O. J. and Briggs, D. and Ball, S. and Cockwell, P. and Patterson, C.C. and Maxwell, A. P. and Gough, S. C. L. and Borrows, R. (2010) Association of caveolin-1 gene polymorphism with kidney transplant fibrosis and allograft failure. JAMA - Journal of the American Medical Association, 303 (13). pp. 1282-1287. ISSN 0098-7484

Moore, Jason and McKnight, Amy Jayne and Döhler, Bernd and Simmonds, Matthew J. and Courtney, Aisling E. and Brand, Oliver J. and Briggs, David and Ball, Simon and Cockwell, Paul and Patterson, Christopher C. and Maxwell, Alexander P. and Gough, Stephen C. L. and Opelz, Gerhard and Borrows, Richard (2012) Donor ABCB1 variant associates with increased risk for kidney allograft failure. Journal of the American Society of Nephrology, 23 (11). pp. 1891-1899. ISSN 1046-6673

Newby, P. R. and Roberts-Davies, E. L. and Brand, O. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2007) Tag SNP screening of the PDCD1 gene for association with Graves' disease. Clinical Endocrinology, 67 (1). pp. 125-128. ISSN 0300-0664

Newby, Paul R. and Pickles, Oliver J. and Mazumdar, Samaresh and Brand, Oliver J. and Carr-Smith, Jacqueline D. and Pearce, Simon H. S. and Franklyn, Jayne A. and Evans, David M. and Simmonds, Matthew J. and Gough, Stephen C. L. and Welcome Trust Case-Control Consortium (WTCCC), . (2010) Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study. European Journal of Human Genetics, 18 (9). pp. 1021-1026. ISSN 1018-4813

Plagnol, Vincent and Howson, Joanna M. M. and Smyth, Deborah J. and Walker, Neil and Hafler, Jason P. and Wallace, Chris and Stevens, Helen and Jackson, Laura and Simmonds, Matthew J. and T1D Genetics Consortium, - and Bingley, Polly J. and Gough, Stephen C. and Todd, John A. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genetics, 7 (8). ISSN 1553-7390

Simmonds, M. J. and Gough, S. C. L. (2004) Unravelling the genetic complexity of autoimmune thyroid disease: HLA, CTLA-4 and beyond. Clinical and Experimental Immunology, 136 (1). pp. 1-10. ISSN 0009-9104

Simmonds, M. J. and Heward, J.M. and Howson, J.M.M. and Foxall, H. and Nithiyananthan, R. and Franklyn, J.A. and Gough, S.C.L. (2004) A systematic approach to the assesment of known TNF-alpha polymorphisms in Graves' disease. Genes and Immunity, 5 (4). pp. 267-273. ISSN 1466-4879

Simmonds, M. J. and Howson, J. M. M. and Heward, J. M. and Carr-Smith, J. and Franklyn, J. A. and Todd, J. A. and Gough, S. C. L. (2007) A novel and major association of HLA-C in Graves' disease that eclipses the classical HLA-DRB1 effect. Human Molecular Genetics, 16 (18). pp. 2149-2153. ISSN 0964-6906

Simmonds, Matthew J. (2013) GWAS in autoimmune thyroid disease: redefining our understanding of pathogenesis. Nature Reviews Endocrinology, 9 (5). pp. 277-287. ISSN 1759-5029

Simmonds, Matthew J. and Brand, Oliver J. and Barrett, Jeffrey C. and Newby, Paul R. and Franklyn, Jayne A. and Gough, Stephen C. L. (2010) Association of Fc receptor-like 5 (FCRL5) with Graves' disease is secondary to the effect of FCRL3. Clinical Endocrinology, 73 (5). pp. 654-660. ISSN 0300-0664

Simmonds, Matthew J. and Gough, Stephen C. L. (2011) The search for the genetic contribution to autoimmune thyroid disease: The never ending story? Briefings in Functional Genomics, 10 (2). pp. 77-90. ISSN 2041-2649

Yesmin, K. and Hargreaves, C. and Newby, P. R. and Brand, O. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2010) Association of FcGRIIa with Graves' disease: a potential role for dysregulated autoantibody clearance in disease onset/progression. Clinical Endocrinology, 73 (1). pp. 119-125. ISSN 0300-0664

Zeitlin, A. and Simmonds, M. J. and Gough, S. C. (2008) Genetic developments in autoimmune thyroid disease: an evolutionary process. Clinical Endocrinology, 68 (5). pp. 671-682. ISSN 0300-0664

Zeitlin, A. A. and Heward, J. M. and Brand, O. J. and Newby, P. R. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2006) Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. Clinical Endocrinology, 65 (3). pp. 380-384. ISSN 0300-0664

genetic epigenesis

Simmonds, Matthew J. and Benavente, David and Brand, Oliver J. and Moore, Jason and Ball, Simon and Ferro, Charles J. and Briggs, David and Gough, Stephen C. L. and Borrows, Richard J. (2013) Skewing of female X-chromosome inactivation: an epigenetic risk factor for kidney transplantation outcome. Transplantation, 95 (5). e25-e28. ISSN 0041-1337

genetic identification

Brand, O. J. and Barrett, J. C. and Simmonds, M. J. and Newby, P. R. and McCabe, C. J. and Bruce, C. K. and Kysela, B. and Carr-Smith, J. D. and Brix, T. and Hunt, P. J. and Wiersinga, W. M. and Hegedus, L. and Connell, J. and Wass, J. A. H. and Franklyn, J. A. and Weetman, A. P. and Heward, J. M. and Gough, S. C. L. (2009) Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves' disease. Human Molecular Genetics, 18 (9). pp. 1704-1713. ISSN 0964-6906

genetic linkage

Simmonds, M. J. and Gough, S. C. L. (2004) Unravelling the genetic complexity of autoimmune thyroid disease: HLA, CTLA-4 and beyond. Clinical and Experimental Immunology, 136 (1). pp. 1-10. ISSN 0009-9104

Simmonds, M. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. (2005) IL-13 and chromosome 5q31-q33: problems of identifying association within regions of linkage to Graves' disease. Clinical Endocrinology, 63 (6). pp. 695-697. ISSN 0300-0664

Simmonds, Matthew J. and Gough, Stephen C. L. (2011) The search for the genetic contribution to autoimmune thyroid disease: The never ending story? Briefings in Functional Genomics, 10 (2). pp. 77-90. ISSN 2041-2649

Zeitlin, A. and Simmonds, M. J. and Gough, S. C. (2008) Genetic developments in autoimmune thyroid disease: an evolutionary process. Clinical Endocrinology, 68 (5). pp. 671-682. ISSN 0300-0664

Zeitlin, A. A. and Heward, J. M. and Brand, O. J. and Newby, P. R. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2006) Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. Clinical Endocrinology, 65 (3). pp. 380-384. ISSN 0300-0664

genetic marker

Zeitlin, A. A. and Heward, J. M. and Newby, P. R. and Carr-Smith, J. D. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2008) Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. Genes and Immunity, 9 (4). pp. 358-363. ISSN 1466-4879

genetic polymorphism

Moore, J. and McKnight, A.J. and Simmonds, M. J. and Courtney, A. E. and Hanvesakul, R. and Brand, O. J. and Briggs, D. and Ball, S. and Cockwell, P. and Patterson, C.C. and Maxwell, A. P. and Gough, S. C. L. and Borrows, R. (2010) Association of caveolin-1 gene polymorphism with kidney transplant fibrosis and allograft failure. JAMA - Journal of the American Medical Association, 303 (13). pp. 1282-1287. ISSN 0098-7484

Simmonds, M. J. and Heward, J.M. and Howson, J.M.M. and Foxall, H. and Nithiyananthan, R. and Franklyn, J.A. and Gough, S.C.L. (2004) A systematic approach to the assesment of known TNF-alpha polymorphisms in Graves' disease. Genes and Immunity, 5 (4). pp. 267-273. ISSN 1466-4879

Simmonds, Matthew J. and Benavente, David and Brand, Oliver J. and Moore, Jason and Ball, Simon and Ferro, Charles J. and Briggs, David and Gough, Stephen C. L. and Borrows, Richard J. (2013) Skewing of female X-chromosome inactivation: an epigenetic risk factor for kidney transplantation outcome. Transplantation, 95 (5). e25-e28. ISSN 0041-1337

Simmonds, Matthew J. and Howson, Joanna M. M. and Heward, Joanne M. and Cordell, Heather J. and Foxall, Helen and Carr-Smith, Jackie and Gibson, Sarah M. and Walker, Neil and Tomer, Yaron and Franklyn, Jayne A. and Todd, John A. and Gough, Stephen C. L. (2005) Regression mapping of association between the human leukocyte antigen region and Graves' disease. American Journal of Human Genetics, 76 (1). pp. 157-163. ISSN 0002-9297

genetic predisposition

Hafler, J. P. and Maier, L. M. and Cooper, J. D. and Plagnol, V. and Hinks, A. and Simmonds, M. J. and Stevens, H. and Walker, N. and Healy, B. and Howson, J. M. M. and Maisuria, M. and Duley, S. and Coleman, G. and Gough, S. C. L. and Worthington, J. and Kuchroo, V. K. and Wicker, L. S. and Todd, J. A. and IMSGC, . (2009) CD226 Gly307Ser association with multiple autoimmune diseases. Genes and Immunity, 10 (1). pp. 5-10. ISSN 1466-4879

Hunt, K. A. and Smyth, D. J. and Balschun, T. and Ban, M. and Mistry, V. and Ahmed, T. and Barrett, J. C. and Bhaw-Rosun, L. and Bockett, N. A. and Brand, O. J. and Brouwer, E. and Concannon, P. and Cooper, J. D. and Dias, K-R. M. and van Diemen, C. C. and Dubois, P.C. and Edkins, S. and Fölster-Holst, R. and Fransen, K. and Glass, D. N. and Heap, G. A. R. and Hofmann, S. and Huizinga, T. W. J. and Hunt, S. and Langford, C. and Lee, J. and Mansfield, J. and Giovanna Marrosu, M. and Mathew, C. G. and Mein, C.A. and Müller-Quernheim, J. and Nutland, S. and Onengut-Gumuscu, S. and Ouwehand, W. and Pearce, K. and Prescott, N. and Posthumus, M. D. and Potter, S. and Rosati, G. and Sambrook, J. and Satsangi, J. and Schreiber, S. and Shtir, C. and Simmonds, M. J. and Sudman, M. and Thompson, S. D. and Toes, R. and Trynka, G. and Vyse, T. J. and Walker, N. M. and Weidinger, S. and Zhernakova, A. and Zoledziewska, M. and Weersma, R.K. and Gough, S.C.L. and Sawcer, S. and Wijmenga, C. and Parkes, M. and Cucca, F. and Franke, A. and Deloukas, P. and Rich, S. S. and Todd, J. A. and van Heel, D. A. (2011) Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry. Nature Genetics, 44 (1). pp. 3-5. ISSN 10614036

Moore, J. and McKnight, A.J. and Simmonds, M. J. and Courtney, A. E. and Hanvesakul, R. and Brand, O. J. and Briggs, D. and Ball, S. and Cockwell, P. and Patterson, C.C. and Maxwell, A. P. and Gough, S. C. L. and Borrows, R. (2010) Association of caveolin-1 gene polymorphism with kidney transplant fibrosis and allograft failure. JAMA - Journal of the American Medical Association, 303 (13). pp. 1282-1287. ISSN 0098-7484

Simmonds, M. J. and Howson, J. M. M. and Heward, J. M. and Carr-Smith, J. and Franklyn, J. A. and Todd, J. A. and Gough, S. C. L. (2007) A novel and major association of HLA-C in Graves' disease that eclipses the classical HLA-DRB1 effect. Human Molecular Genetics, 16 (18). pp. 2149-2153. ISSN 0964-6906

Yesmin, K. and Hargreaves, C. and Newby, P. R. and Brand, O. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2010) Association of FcGRIIa with Graves' disease: a potential role for dysregulated autoantibody clearance in disease onset/progression. Clinical Endocrinology, 73 (1). pp. 119-125. ISSN 0300-0664

Zeitlin, A. A. and Heward, J. M. and Newby, P. R. and Carr-Smith, J. D. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2008) Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. Genes and Immunity, 9 (4). pp. 358-363. ISSN 1466-4879

genetic risk

Chand, S. and Holle, J. U. and Hilhorst, M. and Simmonds, M. J. and Smith, S. and Kamesh, L. and Hewins, P. and McKnight, A. J. and Maxwell, A. P. and Willem Cohen Tervaert, J. and Wieczorek, S. and Harper, L. and Borrows, R. (2013) Caveolin-1 single nucleotide polymorphism in antineutrophil cytoplasmic antibody associated vasculitis. PLoS ONE, 8 (7). ISSN 1932-6203

Hunt, K. A. and Mistry, V. and Bockett, N. A. and Ahmad, T. and Ban, M. and Barker, J. N. and Barrett, J. C. and Blackburn, H. and Brand, O. J. and Burren, O. and Capon, F. and Compston, A. and Gough, S. C. L. and Jostins, L. and Kong, Y. and Lee, J. C. and Lek, M. and MacArthur, D. G. and Mansfield, J. C. and Mathew, C. G. and Mein, C. A. and Mirza, M. and Nutland, S. and Onengut-Gumuscu, S. and Papouli, E. and Parkes, M. and Rich, S. S. and Sawcer, S. and Satsangi, J. and Simmonds, M. J. and Trembath, R. C. and Walker, N. M. and Wozniak, E. and Todd, J. A. and Simpson, M. A. and Plagnol, V. and van Heel, D. A. (2013) Negligible impact of rare autoimmune-locus coding-region variants on missing heritability. Nature, 498 (7453). pp. 232-235. ISSN 0028-0836

Hunt, K. A. and Smyth, D. J. and Balschun, T. and Ban, M. and Mistry, V. and Ahmed, T. and Barrett, J. C. and Bhaw-Rosun, L. and Bockett, N. A. and Brand, O. J. and Brouwer, E. and Concannon, P. and Cooper, J. D. and Dias, K-R. M. and van Diemen, C. C. and Dubois, P.C. and Edkins, S. and Fölster-Holst, R. and Fransen, K. and Glass, D. N. and Heap, G. A. R. and Hofmann, S. and Huizinga, T. W. J. and Hunt, S. and Langford, C. and Lee, J. and Mansfield, J. and Giovanna Marrosu, M. and Mathew, C. G. and Mein, C.A. and Müller-Quernheim, J. and Nutland, S. and Onengut-Gumuscu, S. and Ouwehand, W. and Pearce, K. and Prescott, N. and Posthumus, M. D. and Potter, S. and Rosati, G. and Sambrook, J. and Satsangi, J. and Schreiber, S. and Shtir, C. and Simmonds, M. J. and Sudman, M. and Thompson, S. D. and Toes, R. and Trynka, G. and Vyse, T. J. and Walker, N. M. and Weidinger, S. and Zhernakova, A. and Zoledziewska, M. and Weersma, R.K. and Gough, S.C.L. and Sawcer, S. and Wijmenga, C. and Parkes, M. and Cucca, F. and Franke, A. and Deloukas, P. and Rich, S. S. and Todd, J. A. and van Heel, D. A. (2011) Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry. Nature Genetics, 44 (1). pp. 3-5. ISSN 10614036

Moore, Jason and McKnight, Amy Jayne and Döhler, Bernd and Simmonds, Matthew J. and Courtney, Aisling E. and Brand, Oliver J. and Briggs, David and Ball, Simon and Cockwell, Paul and Patterson, Christopher C. and Maxwell, Alexander P. and Gough, Stephen C. L. and Opelz, Gerhard and Borrows, Richard (2012) Donor ABCB1 variant associates with increased risk for kidney allograft failure. Journal of the American Society of Nephrology, 23 (11). pp. 1891-1899. ISSN 1046-6673

Newby, Paul R. and Pickles, Oliver J. and Mazumdar, Samaresh and Brand, Oliver J. and Carr-Smith, Jacqueline D. and Pearce, Simon H. S. and Franklyn, Jayne A. and Evans, David M. and Simmonds, Matthew J. and Gough, Stephen C. L. and Welcome Trust Case-Control Consortium (WTCCC), . (2010) Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study. European Journal of Human Genetics, 18 (9). pp. 1021-1026. ISSN 1018-4813

Zeitlin, A. and Simmonds, M. J. and Gough, S. C. (2008) Genetic developments in autoimmune thyroid disease: an evolutionary process. Clinical Endocrinology, 68 (5). pp. 671-682. ISSN 0300-0664

genetic screening

Newby, Paul R. and Pickles, Oliver J. and Mazumdar, Samaresh and Brand, Oliver J. and Carr-Smith, Jacqueline D. and Pearce, Simon H. S. and Franklyn, Jayne A. and Evans, David M. and Simmonds, Matthew J. and Gough, Stephen C. L. and Welcome Trust Case-Control Consortium (WTCCC), . (2010) Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study. European Journal of Human Genetics, 18 (9). pp. 1021-1026. ISSN 1018-4813

Simmonds, Matthew J. and Gough, Stephen C. L. (2011) The search for the genetic contribution to autoimmune thyroid disease: The never ending story? Briefings in Functional Genomics, 10 (2). pp. 77-90. ISSN 2041-2649

Zeitlin, A. A. and Heward, J. M. and Brand, O. J. and Newby, P. R. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2006) Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. Clinical Endocrinology, 65 (3). pp. 380-384. ISSN 0300-0664

genetic susceptibility

Brand, O. J. and Barrett, J. C. and Simmonds, M. J. and Newby, P. R. and McCabe, C. J. and Bruce, C. K. and Kysela, B. and Carr-Smith, J. D. and Brix, T. and Hunt, P. J. and Wiersinga, W. M. and Hegedus, L. and Connell, J. and Wass, J. A. H. and Franklyn, J. A. and Weetman, A. P. and Heward, J. M. and Gough, S. C. L. (2009) Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves' disease. Human Molecular Genetics, 18 (9). pp. 1704-1713. ISSN 0964-6906

Cooper, J. D. and Simmonds, M. J. and Walker, N.M. and Burren, O. and Brand, O.J. and Guo, H. and Wallace, C. and Stevens, H. and Coleman, G and Franklyn, J.A. and Todd, J.A. and Gough, S.C.L. (2012) Seven newly identified loci for autoimmune thyroid disease. Human Molecular Genetics, 21 (23). pp. 5202-5208. ISSN 0964-6906

Gough, S .C. L. and Simmonds, Matthew J. (2007) The HLA region and autoimmune disease: associations and mechanisms of action. Current Genomics, 8 (7). pp. 453-465. ISSN 1389-2029

Hafler, J. P. and Maier, L. M. and Cooper, J. D. and Plagnol, V. and Hinks, A. and Simmonds, M. J. and Stevens, H. and Walker, N. and Healy, B. and Howson, J. M. M. and Maisuria, M. and Duley, S. and Coleman, G. and Gough, S. C. L. and Worthington, J. and Kuchroo, V. K. and Wicker, L. S. and Todd, J. A. and IMSGC, . (2009) CD226 Gly307Ser association with multiple autoimmune diseases. Genes and Immunity, 10 (1). pp. 5-10. ISSN 1466-4879

Heward, J. M. and Simmonds, M. J. and Carr-Smith, J. and Foxall, H. and Franklyn, J. A. and Gough, S. C. L. (2004) A single nucleotide polymorphism in the CD40 gene on chromosome 20q (GD-2) provides no evidence for susceptibility to Graves' disease in UK Caucasians. Clinical Endocrinology, 61 (2). pp. 269-272. ISSN 0300-0664

Newby, Paul R. and Pickles, Oliver J. and Mazumdar, Samaresh and Brand, Oliver J. and Carr-Smith, Jacqueline D. and Pearce, Simon H. S. and Franklyn, Jayne A. and Evans, David M. and Simmonds, Matthew J. and Gough, Stephen C. L. and Welcome Trust Case-Control Consortium (WTCCC), . (2010) Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study. European Journal of Human Genetics, 18 (9). pp. 1021-1026. ISSN 1018-4813

Simmonds, M. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. (2005) The CD40 Kozak SNP: a new susceptibility loci for Graves' disease? Clinical Endocrinology, 63 (2). pp. 232-233. ISSN 0300 0664

Simmonds, Matthew J. (2013) GWAS in autoimmune thyroid disease: redefining our understanding of pathogenesis. Nature Reviews Endocrinology, 9 (5). pp. 277-287. ISSN 1759-5029

Simmonds, Matthew J. and Heward, Joanne M. and Kelly, M. Ann and Allahabadia, Amit and Foxall, Helen and Gordon, Caroline and Franklyn, Jayne A. and Gough, Stephen C. L. (2002) A nonsense mutation in exon 2 of the DNase I gene is not present in UK subjects with systemic lupus erythematosus and Graves' disease: Comment on the article by Rood et al. Arthritis and Rheumatism, 46 (11). pp. 3109-3110. ISSN 0004-3591

Zeitlin, A. and Simmonds, M. J. and Gough, S. C. (2008) Genetic developments in autoimmune thyroid disease: an evolutionary process. Clinical Endocrinology, 68 (5). pp. 671-682. ISSN 0300-0664

Zeitlin, A. A. and Heward, J. M. and Brand, O. J. and Newby, P. R. and Franklyn, J. A. and Gough, S. C. L. and Simmonds, M. J. (2006) Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. Clinical Endocrinology, 65 (3). pp. 380-384. ISSN 0300-0664

genetic transfection

Simmonds, M. J. and Heward, J. M. and Franklyn, J. A. and Gough, S. C. L. (2005) The CD40 Kozak SNP: a new susceptibility loci for Graves' disease? Clinical Endocrinology, 63 (2). pp. 232-233. ISSN 0300 0664

genetic variability

Ali, Nadir and Coulson-Thomas, Yvette M. and Norton, Andrew L. and Dixon, Ronald A. and Williams, D. Ross (2013) Announcement of population data: genetic data for 17 Y-STR AmpFℓSTR® Yfiler™ markers from an immigrant Pakistani population in the UK (British Pakistanis). Forensic Science International: Genetics, 7 (2). e40-e42. ISSN 1872-4973

Brand, O. J. and Barrett, J. C. and Simmonds, M. J. and Newby, P. R. and McCabe, C. J. and Bruce, C. K. and Kysela, B. and Carr-Smith, J. D. and Brix, T. and Hunt, P. J. and Wiersinga, W. M. and Hegedus, L. and Connell, J. and Wass, J. A. H. and Franklyn, J. A. and Weetman, A. P. and Heward, J. M. and Gough, S. C. L. (2009) Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves' disease. Human Molecular Genetics, 18 (9). pp. 1704-1713. ISSN 0964-6906

Chand, S. and Chue, C. D. and Edwards, N. C. and Hodson, J. and Simmonds, M. J. and Hamilton, A. and Gough, S. C. L. and Harper, L. and Steeds, R. P. and Townend, J. N. and Ferro, C. J. and Borrows, R. (2015) Endothelial nitric oxide synthase single nucleotide polymorphism and left ventricular function in early chronic kidney disease. PLoS ONE, 10 (1). ISSN 1932-6203

Chand, S. and Holle, J. U. and Hilhorst, M. and Simmonds, M. J. and Smith, S. and Kamesh, L. and Hewins, P. and McKnight, A. J. and Maxwell, A. P. and Willem Cohen Tervaert, J. and Wieczorek, S. and Harper, L. and Borrows, R. (2013) Caveolin-1 single nucleotide polymorphism in antineutrophil cytoplasmic antibody associated vasculitis. PLoS ONE, 8 (7). ISSN 1932-6203

Hafler, J. P. and Maier, L. M. and Cooper, J. D. and Plagnol, V. and Hinks, A. and Simmonds, M. J. and Stevens, H. and Walker, N. and Healy, B. and Howson, J. M. M. and Maisuria, M. and Duley, S. and Coleman, G. and Gough, S. C. L. and Worthington, J. and Kuchroo, V. K. and Wicker, L. S. and