Items where Subject is "B Subjects allied to Medicine > B210 Pharmacology"

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(3,4 dihydro 2h pyranol2,3 bquinolin 7yl)(cis 4 ethoxycycloexyl) methanone 1 (2,4 dichlorophenyl) 5 (4 iodophenyl) 4 methyl n (1 piperidyl) 1h pyrazole 3 carboxamide 1 amino 1,3 cyclopentanedicarboxylic acid 1,2,3,6 tetrahydro 1 methyl 4 phenylpyridine 2 amino 2 (2 carboxycyclopropyl) 3 (xanthen 9 yl) propionic acid 2 amino 2 (2 carboxycyclopropyl) 3 (xanthen 9 yl)propionic acid 2 amino 3 (3,4 dichlorobenzyloxy) 6 fluorobicyclo3.1.0hexane 2,6 dicarboxylic acid 2 amino 4 phosphonobutyric acid 2 amino 5 phosphonovaleric acid 2 methyl 6 (2 phenylvinyl)pyridine 2 methyl 6 (phenylethynyl)pyridine 2,3 dihydro 5 methyl 3 (morpholinomethyl) 6 (1 naphthoyl)pyrrolo1,2,3 de1,4benzoxazine 3 (3, 4 dichlorobenzylamino) propyl (diethoxymethyl) phosphinic acid 3 (3,4 dichlorobenzylamino)propyl(diethoxymethyl)phosphinic acid 3,5 dihydroxyphenylglycine 4 (3 tert butylamino 2 hydroxypropoxy) 2 benzimidazolone 4 amino 2 oxabicyclo3.1.0hexane 4,6 dicarboxylic acid 4 amino 2 thiabicyclo3.1.0hexane 4,6 dicarboxylic acid 2,2 dioxide 4 aminobutyric acid 4 phosphonophenylglycine 5-aminolevulinic acid hexyl ester 6 hydroxydopamine 6 methyl 2 (phenylethynyl)pyridine 6 methyl 2 phenylazo 3 pyridinol 6-methyl-2-(phenylethynyl)pyridine 9h xanthene 9 carboxylic acid(4 trifluoromethyloxazol 2 yl)amide 9h xanthene 9 carboxylix acid (4 trifluoromethyl oxazol 2 yl)amide Absence epilepsy Adolescent Adult Aged Aged, 80 and over Amino Acids Analgesics, Non-Narcotic Analysis of Variance Animals Anthraquinones Anti-Inflammatory Agents Antibiotics Anticoagulants Anticonvulsants Antidepressive Agents, Tricyclic Aorta, Thoracic Apoptosis Arachidonic Acids Area Under Curve Article Association Learning Asthma Astrocytes August Copenhagen Irish rat Avoidance Learning BEAS-2B epithelial cells Baclofen Behavior, Animal Benzofurans Benzopyrans Benzoxazines Benzylamines Bicyclo Compounds, Heterocyclic Biological Availability Blotting, Western Brain Brain Infarction Brain Mapping Brain Neoplasms CB receptors COS Cells Calcium Cannabinoid Receptor Agonists Caprolactam Carbon Radioisotopes Carrier Proteins Cell Line, Tumor Cells, Cultured Central Nervous System Diseases Cercopithecus aethiops Cerebral Cortex Cerebral Infarction Chemical sympathectomy Chromatography, Liquid Chronic treatment Ciprofloxacin Circadian Rhythm Coloring Agents Convulsants Corticosteroid Corticosterone Cross-Over Studies Crystal Cyclic AMP Cyclins Cycloleucine Cytosol DNA Primers Densitometry Disease Models, Animal Dizocilpine Maleate Dose-Response Relationship, Drug Down-Regulation Drug Monitoring Electroencephalography Electrophysiology Encephalomyelitis, Autoimmune, Experimental Endocannabinoids Endothelin-1 Endothelium, Vascular Epilepsy Epilepsy, Absence Epithelial cells Estradiol Evans Blue Evoked Potentials Excitatory Amino Acid Antagonists Female Forelimb Forskolin Functional Laterality Fungal Proteins G protein coupled receptor GABA Agonists GABA Antagonists GABA Modulators GABA-A Receptor Antagonists GABAergic system GILZ GRM1 gene GRM2 gene Gastrointestinal Motility Gene Expression Gene Expression Regulation Genetic Glial Fibrillary Acidic Protein Glucocorticoid Glucose Glutamic Acid Half-Life Hepatitis, Toxic Hepatocytes Heterocyclic compounds Hindlimb Histamine Humans Hydrolysis I-kappa B Kinase IL-6 IL-8 Imidazoles Immunohistochemistry In Vitro Indoles Infarction, Middle Cerebral Artery Inflammation Injections, Intravenous Injections, Intraventricular Intestinal Secretions Intestine, Large Ischemia Ischemic Attack, Transient Islets of Langerhans Kainic Acid Ki-67 Antigen Kinetics Leukocytes, Mononuclear Ligands Long-Term Potentiation MAP Kinase Signaling System MTEP Magnetic Resonance Imaging Male Mepyramine Mice Mice, Inbred C57BL Mice, Inbred Strains Mice, Knockout Mice, Nude Microdialysis Microscopy, Electron Middle Aged Models, Molecular Molecular Molecular Targeted Therapy Morpholines Motor Activity Movement Munc18 Proteins Munc18 protein Muscle Contraction NF-?B NF-kappa B NHBE Naphthalenes Neoplastic Stem Cells Nerve Net Nervous System Physiology Neural Pathways Neuroglia Neuroprotective Agents Nucleic Acid Synthesis Inhibitors Osteoblasts Oxazines PBN Pancreas Parkinson disease Pentylenetetrazole Perforant Pathway Perfusion Phenazopyridine Phosphatidylinositol Phosphates Phosphinic Acids Photosensitizing Agents Piperidines Polyunsaturated Alkamides Postural Balance Pregnancy Prenatal Exposure Delayed Effects Psychomotor Performance Pulmonary epithelium Purkinje cell Pyrazoles Pyridines Quinolines R-SNARE Proteins RANTES RANTES, allergic encephalitis RNA, Messenger RO0711401 Rab protein Rats Rats, Inbred ACI Rats, Inbred F344 Rats, Inbred Lew Rats, Inbred Strains Rats, Mutant Strains Rats, Sprague-Dawley Rats, Wistar Rattus Reaction Time Receptor, Cannabinoid, CB1 Receptors, Adrenergic, beta Receptors, Drug Receptors, Metabotropic Glutamate Receptors, Opioid Reflex Reverse Transcriptase Polymerase Chain Reaction Rimonabant Seizure Seizures Severity of Illness Index Signal Transduction Smooth muscle cells Somatosensory Cortex Spike-wave discharges Spinocerebellar Ataxias Spinocerebellar Ataxias, Animals Sprague Dawley rat Stress, Psychological Supersensitivity Synapses Synapsins Synaptic Transmission T lymphocyte, Animals Tetrazolium Salts, Animalia Thalamic Nuclei Thalamus Tissue Fixation Tolerance Transactivation Transcription Up-Regulation VU0360172 WAG/Rij rats WIN55,212, Animals Western blotting Western blotting, 2-Amino-5-phosphonovalerate Western blotting, Age Factors Western blotting, Aging Western blotting, Amino Acids Western blotting, Animals Wistar albino Glaxo rat Wistar albino Glaxo rat, Animals Wistar rat, Allosteric Regulation Xanthenes absence acetylcysteine adenosine triphosphatase (potassium) adolescent adult aging agmatine algorithm alpha 1 adrenergic receptor blocking agent alpha ethylglutamate alpha methyl 4 tetrazolylphenylglycine alpha methylserine o phosphate amantadine amenamevir amide amino acid receptor blocking agent aminolevulinic acid aminolevulinic acid hexyl ester analysis of variance anandamide animal animal cell animal experiment animal model animal tissue anti-inflammatories anti-inflammatory effects antibiotics antidepressant activity antidepressant agent antiestrogen antineoplastic activity antiviral anxiety aorta area under the curve article astrocyte attenuation atypical antipsychotic agent autism azd 2066 basimglurant behavior benzoxazine derivative beta adrenergic receptor beta-agonists beta2-adrenoceptor agonists bioavailability blood body posture brain brain blood vessel brain capillary brain cortex brain damage brain depth stimulation brain infarction size brain ischemia brain level brain protection brain protein brain region brain slice brain tumor calcium cell level calcium ion calcium transport calixarenes cancer cell culture cancer graft cancer growth cancer inhibition cannabinoid 1 receptor cannabinoid 1 receptor agonist cannabis addiction carbon carbon 14 caudate nucleus cell culture cell death cell proliferation cellular distribution central nervous system central nervous system disease cerebellum cerebellum disease cerebrovascular accident chemical binding chemistry cinnabarinic acid clinical trial cocaine dependence compounds concentration response conference paper confidence interval controlled clinical trial controlled study convalescence corpus callosum corpus striatum corticosteroid crossover procedure culture medium cyclic AMP cyclin D1 cyclin D2 cytochrome P450 3A4 cytokines data analysis dentate gyrus depolarization depression desipramine dexamethasones dextro aspartic acid diabetes mellitus dialysate diazepam diazoxide dihydroxyphenylglycine dipraglurant disease model disease severity dizocilpine dose calculation dose response dose time effect relation down regulation drug absorption drug administration route drug antagonism drug bioavailability drug blood level drug clearance drug cost drug dependence drug derivative drug design drug determination drug distribution drug dose comparison drug effect drug effects drug efficacy drug half life drug mechanism drug metabolite drug potentiation drug receptor binding drug research drug safety drug targeting drug tolerability drug-resistance dyskinesia educational intervention efaroxan electrocorticography electroencephalogram electroencephalography electromyography electron microscopy endothelin 1 endothelin 1, age endothelium cell enzyme enzyme activation enzyme activity epithelial cells erythromycin ex vivo study excitatory amino acid transporter excitatory amino acid transporter 1 female flow fluconazole food and drug administration forelimb forskolin fragile X syndrome frontal cortex fura 2 gamma rhythm gene gene deletion gene expression gene expression regulation gene inactivation gene transcription general practice genetic absence epilepsy genetic disorder genetic model genetics glia cell glioblastoma glioma glioma cell glucocorticoids glutamate receptor 1 glutamate receptor 3 glutamate receptor 4 glutamate receptor antagonist glutamic acid glycine derivative glycoprotein P granule cell granulocyte/macrophage colony-stimulating factor (GM-CSF) half life time happy puppet syndrome hexaminolevulinate c 14 high performance liquid chromatography hippocampus human human cell human experiment hydrolysis hypothesis idazoxan imidazoline derivative imidazoline receptor imipramine immune response immunoblotting immunocytochemistry immunohistochemistry immunoreactivity in situ hybridization in vitro study in vivo study inflammation inhibition kinetics injection insulin insulin release interleukin 1beta interleukin 6 interleukin 8 interviews intestine contraction intestine perfusion intravesical drug administration ketamine knockout mouse kynurenine lactation large intestine latent period learning learning disorder leukocyte levacecarnine ligand lipopolysaccharide liquid chromatography liver cell liver injury liver necrosis liver toxicity long term depression long term potentiation mGlu5 receptor major depression male mass spectrometry mavoglurant maze test medical literature medical research melanoma memory memory disorder messenger RNA metabolism metabolite metabotropic receptor metabotropic receptor 1 metabotropic receptor 1alpha metabotropic receptor 2 metabotropic receptor 3 metabotropic receptor 3, adaptation metabotropic receptor 4 metabotropic receptor 5 metabotropic receptor 5, aged metabotropic receptor 7 metabotropic receptor 8 metabotropic receptor 8, absence metabotropic receptor agonist metabotropic receptor antagonist metabotropic receptor, absence methodology microdosing microfluorometry microvasculature midazolam middle aged, Administration, Intravesical middle cerebral artery middle cerebral artery occlusion mitochondria mitogen activated protein kinase molecular model molecular pathology molecularly targeted therapy morpholine derivative mouse movement (physiology) multiple sclerosis mutagenesis mutant n methyl dextro aspartic acid receptor n methyl dextro aspartic acid receptor stimulating agent n phenyl 7 (hydroxyimino)cyclopropabchromen 1a caboxamide n phenyl 7 (hydroxyimino)cyclopropabchromen1a carboxamide naphthalene derivative nerve cell nerve cell network nerve cell plasticity nervous system electrophysiology neural stem cell neuroleptic agent neurologic disease neuromodulation neuroprotection neurotransmission neurotransmitter release newborn nociceptin nonhuman normal human nuclear magnetic resonance imaging nucleotide sequence nucleus accumbens nude mouse opiate receptor opioid like receptor 1 oscillation osmotic minipump oxidative stress p38 Mitogen-Activated Protein Kinases pancreas islet paracetamol parvalbumin passive avoidance pathogenesis pathology pathophysiology patient participation pentetrazole pentobarbital perforant nerve tract perinatal period pertussis toxin phase 2 clinical trial (topic) phentolamine phentolamine mesylate, animal tissue phosphatidylinositol 3 kinase phosphoserine photosensitizing agent, absence of side effects physiology piperidine derivative polyphosphoinositide polyphosphoinositide, absence polyphosphoinositide, animal experiment pomaglumetad methionil practice guideline prenatal stress primary care priority journal priority journal, Administration, Oral priority journal, Adrenergic alpha-Antagonists pritelivir prostaglandin GH synthase protected learning time protein Homer 1a protein analysis protein expression protein function protein hydrolysis protein interaction protein localization protein protein interaction protein synthesis protein synthesis inhibition publication putamen pyrazole derivative, animal experiment pyridine derivative, allosterism qualitative research rab3A GTP-Binding Protein radiation dose radioactivity radiopharmaceutical agent rat rat strain rat strain, Analysis of Variance rat, Adrenergic Uptake Inhibitors rat, Analysis of Variance reactive oxygen metabolite receptor binding, Adaptation, Physiological receptor blocking, 1-Phosphatidylinositol 3-Kinase receptor blocking, Acetaminophen receptor down regulation receptor gene receptor intrinsic activity receptor protein receptor subtype receptor subtype, antigen presenting cell receptor upregulation recording reduction regulatory mechanism respiratory mucosa review rhein rimonabant, absence ro 0711401 ro 4419513 ro 4432717 schizophrenia seizure sennoside, animal experiment sensitivity analysis sensor sensorimotor function sensorimotor integration serotonin 2A receptor signal noise ratio signal transduction sodium chloride, absence somatosensory cortex spatial memory species comparison spike spike wave spike wave discharge spinal cord state dependent learning statistical analysis stem cell stereotactic device stimulation strain gauge transducer striate cortex symptom, Aminobutyric Acids syn 119 synapse synapse vesicle synapsin I synapsin II synaptic transmission synaptobrevin synaptophysin synaptosomal associated protein 25 synaptosome syntaxin 1 tandem mass spectrometry tandem mass spectrometry, Animals task performance tert butyl hydroperoxide, animal cell tert-Butylhydroperoxide thalamocortical tract thalamocortical tract, Animals thalamus thalamus nucleus thalamus reticular nucleus theta rhythm tissue preparation tobacco dependence tolbutamide toxicology transducer, Animal triphenyltetrazolium, article tristetrapolin tubercidin umbilical vein unclassified drug unclassified drug, allosterism unclassified drug, animal cell unclassified drug, animal experiment unclassified drug, animal tissue vascular endothelium vascular ring, Animals ventroposterolateral nucleus, Allosteric Regulation ventroposteromedial thalamic nucleus, Anandamide vesicular glutamate transporter 1, animal experiment volunteer vu 0360172 warfarin wild type, Animals zk 253, adult zk 253, area under the curve
Number of items at this level: 1318.

(3,4 dihydro 2h pyranol2,3 bquinolin 7yl)(cis 4 ethoxycycloexyl) methanone

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

1 (2,4 dichlorophenyl) 5 (4 iodophenyl) 4 methyl n (1 piperidyl) 1h pyrazole 3 carboxamide

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

1 amino 1,3 cyclopentanedicarboxylic acid

Cinque, C. and Zuena, A .R. and Casolini, P. and Ngomba, Richard T. and Melchiorri, D. and Maccari, S. and Nicoletti, F. and Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Matrisciano, F. and Storto, M. and Ngomba, Richard T. and Cappuccio, I. and Caricasole, A. and Scaccianoce, S. and Riozzi, B. and Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

1,2,3,6 tetrahydro 1 methyl 4 phenylpyridine

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

2 amino 2 (2 carboxycyclopropyl) 3 (xanthen 9 yl) propionic acid

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

2 amino 2 (2 carboxycyclopropyl) 3 (xanthen 9 yl)propionic acid

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Cinque, C. and Zuena, A .R. and Casolini, P. and Ngomba, Richard T. and Melchiorri, D. and Maccari, S. and Nicoletti, F. and Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Matrisciano, F. and Storto, M. and Ngomba, Richard T. and Cappuccio, I. and Caricasole, A. and Scaccianoce, S. and Riozzi, B. and Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

2 amino 3 (3,4 dichlorobenzyloxy) 6 fluorobicyclo3.1.0hexane 2,6 dicarboxylic acid

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

2 amino 4 phosphonobutyric acid

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Matrisciano, F. and Storto, M. and Ngomba, Richard T. and Cappuccio, I. and Caricasole, A. and Scaccianoce, S. and Riozzi, B. and Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

2 amino 5 phosphonovaleric acid

Manahan-Vaughan, D. and Ngomba, Richard T. and Storto, M. and Kulla, A. and Catania, M. V. and Chiechio, S. and Rampello, L. and Passarelli, F. and Capece, A. and Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

2 methyl 6 (2 phenylvinyl)pyridine

Storto, Marianna and Ngomba, Richard T. and Battaglia, Giuseppe and Freitas, Isabel and Griffini, Patrizia and Richelmi, Plinio and Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

2 methyl 6 (phenylethynyl)pyridine

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Storto, Marianna and Ngomba, Richard T. and Battaglia, Giuseppe and Freitas, Isabel and Griffini, Patrizia and Richelmi, Plinio and Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

2,3 dihydro 5 methyl 3 (morpholinomethyl) 6 (1 naphthoyl)pyrrolo1,2,3 de1,4benzoxazine

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

3 (3, 4 dichlorobenzylamino) propyl (diethoxymethyl) phosphinic acid

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

3 (3,4 dichlorobenzylamino)propyl(diethoxymethyl)phosphinic acid

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

3,5 dihydroxyphenylglycine

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

4 (3 tert butylamino 2 hydroxypropoxy) 2 benzimidazolone

Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

4 amino 2 oxabicyclo3.1.0hexane 4,6 dicarboxylic acid

Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Matrisciano, F. and Storto, M. and Ngomba, Richard T. and Cappuccio, I. and Caricasole, A. and Scaccianoce, S. and Riozzi, B. and Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

4 amino 2 thiabicyclo3.1.0hexane 4,6 dicarboxylic acid 2,2 dioxide

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

4 aminobutyric acid

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

4 phosphonophenylglycine

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

5-aminolevulinic acid hexyl ester

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

6 hydroxydopamine

Chess-Williams, RG and Grassby, Paul and Culling, W. and Penny, W. and Broadley, K. J. and Sheridan, D. J. (1985) Cardiac postjunctional supersensitivity to β-agonists after chronic chemical sympathectomy with 6-hydroxydopamine. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 329 (2). pp. 162-166. ISSN 0028-1298

6 methyl 2 (phenylethynyl)pyridine

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

6 methyl 2 phenylazo 3 pyridinol

Storto, Marianna and Ngomba, Richard T. and Battaglia, Giuseppe and Freitas, Isabel and Griffini, Patrizia and Richelmi, Plinio and Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

6-methyl-2-(phenylethynyl)pyridine

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

9h xanthene 9 carboxylic acid(4 trifluoromethyloxazol 2 yl)amide

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

9h xanthene 9 carboxylix acid (4 trifluoromethyl oxazol 2 yl)amide

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Absence epilepsy

D'Amore, V. and Santolini, I. and Celli, R. and Lionetto, L. and De Fusco, A. and Simmaco, M. and van Rijn, C. M. and Vieira, E. and Stauffer, S.R. and Conn, P. J. and Bosco, P. and Nicoletti, F. and van Luijtelaar, G. and Ngomba, R. T. (2014) Head-to head comparison of mGlu1 and mGlu5 receptor activation in chronic treatment of absence epilepsy in WAG/Rij rats. Neuropharmacology, 85 . pp. 91-103. ISSN 0028-3908

D'Amore, V. and Santolini, I. and van Rijn, C.M. and Biagioni, F. and Molinaro, G. and Prete, A. and Conn, P.J. and Lindsley, C.W. and Zhou, Y. and Vinson, P.N. and Rodriguez, A.L. and Jones, C.K and Stauffer, S.R. and Nicoletti, F. and van Luijtelaar, G. and Ngomba, R.T. (2013) Potentiation of mGlu5 receptors with the novel enhancer, VU0360172, reduces spontaneous absence seizures in WAG/Rij rats. Neuropharmacology, 66 . pp. 330-338. ISSN 0028-3908

Adolescent

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Adult

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Aged

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Aged, 80 and over

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Amino Acids

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Analgesics, Non-Narcotic

Storto, Marianna and Ngomba, Richard T. and Battaglia, Giuseppe and Freitas, Isabel and Griffini, Patrizia and Richelmi, Plinio and Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

Analysis of Variance

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Animals

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Manahan-Vaughan, D. and Ngomba, Richard T. and Storto, M. and Kulla, A. and Catania, M. V. and Chiechio, S. and Rampello, L. and Passarelli, F. and Capece, A. and Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Matrisciano, F. and Storto, M. and Ngomba, Richard T. and Cappuccio, I. and Caricasole, A. and Scaccianoce, S. and Riozzi, B. and Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

Moyanova, S.G. and Kortenska, L.V. and Mitreva, R.G. and Pashova, V.D. and Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

Simonyi, Agnes and Ngomba, Richard T. and Storto, Marianna and Catania, Maria V. and Miller, Laura A. and Youngs, Brian and DiGorgi-Gerevini, Valeria and Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

Storto, Marianna and Ngomba, Richard T. and Battaglia, Giuseppe and Freitas, Isabel and Griffini, Patrizia and Richelmi, Plinio and Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Anthraquinones

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Anti-Inflammatory Agents

Chivers, Joanna E. and Gong, Wei and King, Elizabeth M. and Seybold, Joachim and Mak, Judith C. and Donnelly, Louise E. and Holden, Neil S. and Newton, Robert (2006) Analysis of the dissociated steroid RU24858 does not exclude a role for inducible genes in the anti-inflammatory actions of glucocorticoids. Molecular pharmacology, 70 (6). pp. 2084-2095. ISSN 0026-895X

Antibiotics

Gruber, T. (2015) On the way to new shores: caprolactam derivatives as starting point for unprecedented antibiotics. In: Hungarian-German Spring symposium on organic (and) structural chemistry, April 2015, Budapest (Hungary).

Anticoagulants

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Anticonvulsants

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Antidepressive Agents, Tricyclic

Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Aorta, Thoracic

Granata, Filippo and Potenza, Rossella Luisa and Fiori, Anna and Strom, Roberto and Caronti, Brunella and Molinari, Paola and Donsante, Sonia and Citro, Gennaro and Iacovelli, Luisa and De Blasi, Antonio and Ngomba, Richard T. and Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

Apoptosis

Catley, Matthew C. and Chivers, Joanna E. and Holden, Neil S. and Barnes, Peter J. and Newton, Robert (2005) Validation of IKK beta as therapeutic target in airway inflammatory disease by adenoviral-mediated delivery of dominant-negative IKK beta to pulmonary epithelial cells. British journal of pharmacology, 145 (1). pp. 114-22. ISSN 0007-1188

Arachidonic Acids

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Area Under Curve

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Article

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Association Learning

Cinque, C. and Zuena, A .R. and Casolini, P. and Ngomba, Richard T. and Melchiorri, D. and Maccari, S. and Nicoletti, F. and Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Asthma

Holden, Neil S. and Rider, C. F. and Bell, M. J. and Velayudhan, J. and King, E. M. and Kaur, M. and Salmon, M. and Giembycz, M. A. and Newton, R. (2010) Enhancement of inflammatory mediator release by beta(2)-adrenoceptor agonists in airway epithelial cells is reversed by glucocorticoid action. British journal of pharmacology, 160 (2). pp. 410-420. ISSN 0007-1188

Kelly, M. M. and King, E. M. and Rider, C. F. and Gwozd, C. and Holden, Neil S. and Eddleston, J. and Zuraw, B. and Leigh, R. and O'Byrne, P. M. and Newton, R. (2012) Corticosteroid-induced gene expression in allergen-challenged asthmatic subjects taking inhaled budesonide. British Journal of Pharmacology, 165 (6). pp. 1737-1747. ISSN 0007-1188

Astrocytes

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

August Copenhagen Irish rat

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Avoidance Learning

Cinque, C. and Zuena, A .R. and Casolini, P. and Ngomba, Richard T. and Melchiorri, D. and Maccari, S. and Nicoletti, F. and Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

BEAS-2B epithelial cells

Holden, Neil S. and Gong, W. and King, E. M. and Kaur, M. and Giembycz, M. A. and Newton, R. (2007) Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. British journal of pharmacology, 152 (6). pp. 891-902. ISSN 0007-1188

Holden, Neil S. and Rider, C. F. and Bell, M. J. and Velayudhan, J. and King, E. M. and Kaur, M. and Salmon, M. and Giembycz, M. A. and Newton, R. (2010) Enhancement of inflammatory mediator release by beta(2)-adrenoceptor agonists in airway epithelial cells is reversed by glucocorticoid action. British journal of pharmacology, 160 (2). pp. 410-420. ISSN 0007-1188

Baclofen

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Behavior, Animal

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Moyanova, S.G. and Kortenska, L.V. and Mitreva, R.G. and Pashova, V.D. and Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Benzofurans

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

Benzopyrans

Ngomba, Richard T. and Ferraguti, F. and Badura, A. and Citraro, R. and Santolini, I. and Battaglia, G. and Bruno, V. and De Sarro, G. and Simonyi, A. and van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Benzoxazines

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Benzylamines

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Bicyclo Compounds, Heterocyclic

Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Biological Availability

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Blotting, Western

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Cinque, C. and Zuena, A .R. and Casolini, P. and Ngomba, Richard T. and Melchiorri, D. and Maccari, S. and Nicoletti, F. and Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Manahan-Vaughan, D. and Ngomba, Richard T. and Storto, M. and Kulla, A. and Catania, M. V. and Chiechio, S. and Rampello, L. and Passarelli, F. and Capece, A. and Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, Richard T. and Ferraguti, F. and Badura, A. and Citraro, R. and Santolini, I. and Battaglia, G. and Bruno, V. and De Sarro, G. and Simonyi, A. and van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Simonyi, Agnes and Ngomba, Richard T. and Storto, Marianna and Catania, Maria V. and Miller, Laura A. and Youngs, Brian and DiGorgi-Gerevini, Valeria and Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

Brain

Granata, Filippo and Potenza, Rossella Luisa and Fiori, Anna and Strom, Roberto and Caronti, Brunella and Molinari, Paola and Donsante, Sonia and Citro, Gennaro and Iacovelli, Luisa and De Blasi, Antonio and Ngomba, Richard T. and Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Brain Infarction

Moyanova, S.G. and Kortenska, L.V. and Mitreva, R.G. and Pashova, V.D. and Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

Brain Mapping

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Brain Neoplasms

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

CB receptors

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

COS Cells

Granata, Filippo and Potenza, Rossella Luisa and Fiori, Anna and Strom, Roberto and Caronti, Brunella and Molinari, Paola and Donsante, Sonia and Citro, Gennaro and Iacovelli, Luisa and De Blasi, Antonio and Ngomba, Richard T. and Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

Calcium

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

Cannabinoid Receptor Agonists

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Caprolactam

Gruber, T. (2015) On the way to new shores: caprolactam derivatives as starting point for unprecedented antibiotics. In: Hungarian-German Spring symposium on organic (and) structural chemistry, April 2015, Budapest (Hungary).

Carbon Radioisotopes

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Carrier Proteins

Granata, Filippo and Potenza, Rossella Luisa and Fiori, Anna and Strom, Roberto and Caronti, Brunella and Molinari, Paola and Donsante, Sonia and Citro, Gennaro and Iacovelli, Luisa and De Blasi, Antonio and Ngomba, Richard T. and Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

Cell Line, Tumor

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Cells, Cultured

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Central Nervous System Diseases

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Cercopithecus aethiops

Granata, Filippo and Potenza, Rossella Luisa and Fiori, Anna and Strom, Roberto and Caronti, Brunella and Molinari, Paola and Donsante, Sonia and Citro, Gennaro and Iacovelli, Luisa and De Blasi, Antonio and Ngomba, Richard T. and Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

Cerebral Cortex

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Cerebral Infarction

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Chemical sympathectomy

Chess-Williams, RG and Grassby, Paul and Culling, W. and Penny, W. and Broadley, K. J. and Sheridan, D. J. (1985) Cardiac postjunctional supersensitivity to β-agonists after chronic chemical sympathectomy with 6-hydroxydopamine. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 329 (2). pp. 162-166. ISSN 0028-1298

Chromatography, Liquid

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Chronic treatment

D'Amore, V. and Santolini, I. and Celli, R. and Lionetto, L. and De Fusco, A. and Simmaco, M. and van Rijn, C. M. and Vieira, E. and Stauffer, S.R. and Conn, P. J. and Bosco, P. and Nicoletti, F. and van Luijtelaar, G. and Ngomba, R. T. (2014) Head-to head comparison of mGlu1 and mGlu5 receptor activation in chronic treatment of absence epilepsy in WAG/Rij rats. Neuropharmacology, 85 . pp. 91-103. ISSN 0028-3908

Ciprofloxacin

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Circadian Rhythm

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Coloring Agents

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Convulsants

Ngomba, Richard T. and Ferraguti, F. and Badura, A. and Citraro, R. and Santolini, I. and Battaglia, G. and Bruno, V. and De Sarro, G. and Simonyi, A. and van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Corticosteroid

Kelly, M. M. and King, E. M. and Rider, C. F. and Gwozd, C. and Holden, Neil S. and Eddleston, J. and Zuraw, B. and Leigh, R. and O'Byrne, P. M. and Newton, R. (2012) Corticosteroid-induced gene expression in allergen-challenged asthmatic subjects taking inhaled budesonide. British Journal of Pharmacology, 165 (6). pp. 1737-1747. ISSN 0007-1188

Corticosterone

Cinque, C. and Zuena, A .R. and Casolini, P. and Ngomba, Richard T. and Melchiorri, D. and Maccari, S. and Nicoletti, F. and Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Cross-Over Studies

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Crystal

Gruber, T. (2014) Little change, deep impact: solvents and their fundamental influence on crystal formation. In: 65th BHT: Crystallography in Practice, June 2014, Freiberg (Germany).

Cyclic AMP

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Cyclins

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Cycloleucine

Cinque, C. and Zuena, A .R. and Casolini, P. and Ngomba, Richard T. and Melchiorri, D. and Maccari, S. and Nicoletti, F. and Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Cytosol

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

DNA Primers

Chivers, Joanna E. and Gong, Wei and King, Elizabeth M. and Seybold, Joachim and Mak, Judith C. and Donnelly, Louise E. and Holden, Neil S. and Newton, Robert (2006) Analysis of the dissociated steroid RU24858 does not exclude a role for inducible genes in the anti-inflammatory actions of glucocorticoids. Molecular pharmacology, 70 (6). pp. 2084-2095. ISSN 0026-895X

Densitometry

Ngomba, Richard T. and Ferraguti, F. and Badura, A. and Citraro, R. and Santolini, I. and Battaglia, G. and Bruno, V. and De Sarro, G. and Simonyi, A. and van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Disease Models, Animal

Moyanova, S.G. and Kortenska, L.V. and Mitreva, R.G. and Pashova, V.D. and Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Dizocilpine Maleate

Moyanova, S.G. and Kortenska, L.V. and Mitreva, R.G. and Pashova, V.D. and Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

Dose-Response Relationship, Drug

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Down-Regulation

Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

Drug Monitoring

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Electroencephalography

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Manahan-Vaughan, D. and Ngomba, Richard T. and Storto, M. and Kulla, A. and Catania, M. V. and Chiechio, S. and Rampello, L. and Passarelli, F. and Capece, A. and Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard T. and Ferraguti, F. and Badura, A. and Citraro, R. and Santolini, I. and Battaglia, G. and Bruno, V. and De Sarro, G. and Simonyi, A. and van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Electrophysiology

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Encephalomyelitis, Autoimmune, Experimental

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Endocannabinoids

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Endothelin-1

Moyanova, S.G. and Kortenska, L.V. and Mitreva, R.G. and Pashova, V.D. and Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

Endothelium, Vascular

Granata, Filippo and Potenza, Rossella Luisa and Fiori, Anna and Strom, Roberto and Caronti, Brunella and Molinari, Paola and Donsante, Sonia and Citro, Gennaro and Iacovelli, Luisa and De Blasi, Antonio and Ngomba, Richard T. and Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

Epilepsy

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Epilepsy, Absence

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard T. and Ferraguti, F. and Badura, A. and Citraro, R. and Santolini, I. and Battaglia, G. and Bruno, V. and De Sarro, G. and Simonyi, A. and van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Epithelial cells

Newton, Robert and Holden, Neil S. and Catley, Matthew C. and Oyelusi, Wale and Leigh, Richard and Proud, David and Barnes, Peter J. (2007) Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IκB kinase inhibitors. The journal of pharmacology and experimental therapeutics, 321 (2). pp. 734-42. ISSN 0022-3565

Rider, Christopher F. and King, Elizabeth M. and Holden, Neil S. and Giembycz, Mark A. and Newton, Robert (2011) Inflammatory stimuli inhibit glucocorticoid-dependent transactivation in human pulmonary epithelial cells: rescue by long-acting beta2-adrenoceptor agonists. Journal of Pharmacology and Experimental Therapeutics, 338 (3). pp. 860-869. ISSN 0022-3565

Estradiol

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Evans Blue

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Evoked Potentials

Manahan-Vaughan, D. and Ngomba, Richard T. and Storto, M. and Kulla, A. and Catania, M. V. and Chiechio, S. and Rampello, L. and Passarelli, F. and Capece, A. and Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Excitatory Amino Acid Antagonists

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Storto, Marianna and Ngomba, Richard T. and Battaglia, Giuseppe and Freitas, Isabel and Griffini, Patrizia and Richelmi, Plinio and Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

Female

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Forelimb

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Forskolin

HAWTHORN, M. H. and CHESSWILLIAMS, R. G. and Grassby, P. F. and BROADLEY, K. J. (1985) The use of forskolin to investigate the site of cardiac beta-adrenoreceptor supersensitivity. Journal of Autonomic Pharmacology, 5 (3). pp. 231-239. ISSN 0144-1795

Functional Laterality

Moyanova, S.G. and Kortenska, L.V. and Mitreva, R.G. and Pashova, V.D. and Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

Fungal Proteins

Granata, Filippo and Potenza, Rossella Luisa and Fiori, Anna and Strom, Roberto and Caronti, Brunella and Molinari, Paola and Donsante, Sonia and Citro, Gennaro and Iacovelli, Luisa and De Blasi, Antonio and Ngomba, Richard T. and Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

G protein coupled receptor

Nicoletti, F. and Battaglia, G. and Storto, M. and Ngomba, Richard T. and Iacovelli, L. and Arcella, A. and Gradini, R. and Sale, P. and Rampello, L. and De Vita, T. and Di Marco, R. and Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

GABA Agonists

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

GABA Antagonists

Ngomba, Richard T. and Ferraguti, F. and Badura, A. and Citraro, R. and Santolini, I. and Battaglia, G. and Bruno, V. and De Sarro, G. and Simonyi, A. and van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

GABA Modulators

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

GABA-A Receptor Antagonists

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

GABAergic system

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

GILZ

Kelly, M. M. and King, E. M. and Rider, C. F. and Gwozd, C. and Holden, Neil S. and Eddleston, J. and Zuraw, B. and Leigh, R. and O'Byrne, P. M. and Newton, R. (2012) Corticosteroid-induced gene expression in allergen-challenged asthmatic subjects taking inhaled budesonide. British Journal of Pharmacology, 165 (6). pp. 1737-1747. ISSN 0007-1188

GRM1 gene

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

GRM2 gene

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Gastrointestinal Motility

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Gene Expression

Simonyi, Agnes and Ngomba, Richard T. and Storto, Marianna and Catania, Maria V. and Miller, Laura A. and Youngs, Brian and DiGorgi-Gerevini, Valeria and Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

Gene Expression Regulation

Granata, Filippo and Potenza, Rossella Luisa and Fiori, Anna and Strom, Roberto and Caronti, Brunella and Molinari, Paola and Donsante, Sonia and Citro, Gennaro and Iacovelli, Luisa and De Blasi, Antonio and Ngomba, Richard T. and Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

Genetic

Chivers, Joanna E. and Gong, Wei and King, Elizabeth M. and Seybold, Joachim and Mak, Judith C. and Donnelly, Louise E. and Holden, Neil S. and Newton, Robert (2006) Analysis of the dissociated steroid RU24858 does not exclude a role for inducible genes in the anti-inflammatory actions of glucocorticoids. Molecular pharmacology, 70 (6). pp. 2084-2095. ISSN 0026-895X

Glial Fibrillary Acidic Protein

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Glucocorticoid

Holden, Neil S. and Gong, W. and King, E. M. and Kaur, M. and Giembycz, M. A. and Newton, R. (2007) Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. British journal of pharmacology, 152 (6). pp. 891-902. ISSN 0007-1188

Holden, Neil S. and Rider, C. F. and Bell, M. J. and Velayudhan, J. and King, E. M. and Kaur, M. and Salmon, M. and Giembycz, M. A. and Newton, R. (2010) Enhancement of inflammatory mediator release by beta(2)-adrenoceptor agonists in airway epithelial cells is reversed by glucocorticoid action. British journal of pharmacology, 160 (2). pp. 410-420. ISSN 0007-1188

Rider, Christopher F. and King, Elizabeth M. and Holden, Neil S. and Giembycz, Mark A. and Newton, Robert (2011) Inflammatory stimuli inhibit glucocorticoid-dependent transactivation in human pulmonary epithelial cells: rescue by long-acting beta2-adrenoceptor agonists. Journal of Pharmacology and Experimental Therapeutics, 338 (3). pp. 860-869. ISSN 0022-3565

Glucose

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

Glutamic Acid

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Nicoletti, F. and Battaglia, G. and Storto, M. and Ngomba, Richard T. and Iacovelli, L. and Arcella, A. and Gradini, R. and Sale, P. and Rampello, L. and De Vita, T. and Di Marco, R. and Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

Half-Life

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Hepatitis, Toxic

Storto, Marianna and Ngomba, Richard T. and Battaglia, Giuseppe and Freitas, Isabel and Griffini, Patrizia and Richelmi, Plinio and Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

Hepatocytes

Nicoletti, F. and Battaglia, G. and Storto, M. and Ngomba, Richard T. and Iacovelli, L. and Arcella, A. and Gradini, R. and Sale, P. and Rampello, L. and De Vita, T. and Di Marco, R. and Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

Storto, Marianna and Ngomba, Richard T. and Battaglia, Giuseppe and Freitas, Isabel and Griffini, Patrizia and Richelmi, Plinio and Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

Heterocyclic compounds

Newton, Robert and Holden, Neil S. and Catley, Matthew C. and Oyelusi, Wale and Leigh, Richard and Proud, David and Barnes, Peter J. (2007) Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IκB kinase inhibitors. The journal of pharmacology and experimental therapeutics, 321 (2). pp. 734-42. ISSN 0022-3565

Hindlimb

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Histamine

Holden, Neil S. and Gong, W. and King, E. M. and Kaur, M. and Giembycz, M. A. and Newton, R. (2007) Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. British journal of pharmacology, 152 (6). pp. 891-902. ISSN 0007-1188

Humans

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Granata, Filippo and Potenza, Rossella Luisa and Fiori, Anna and Strom, Roberto and Caronti, Brunella and Molinari, Paola and Donsante, Sonia and Citro, Gennaro and Iacovelli, Luisa and De Blasi, Antonio and Ngomba, Richard T. and Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Nicoletti, F. and Battaglia, G. and Storto, M. and Ngomba, Richard T. and Iacovelli, L. and Arcella, A. and Gradini, R. and Sale, P. and Rampello, L. and De Vita, T. and Di Marco, R. and Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Hydrolysis

Cinque, C. and Zuena, A .R. and Casolini, P. and Ngomba, Richard T. and Melchiorri, D. and Maccari, S. and Nicoletti, F. and Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

I-kappa B Kinase

Catley, Matthew C. and Chivers, Joanna E. and Holden, Neil S. and Barnes, Peter J. and Newton, Robert (2005) Validation of IKK beta as therapeutic target in airway inflammatory disease by adenoviral-mediated delivery of dominant-negative IKK beta to pulmonary epithelial cells. British journal of pharmacology, 145 (1). pp. 114-22. ISSN 0007-1188

Newton, Robert and Holden, Neil S. and Catley, Matthew C. and Oyelusi, Wale and Leigh, Richard and Proud, David and Barnes, Peter J. (2007) Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IκB kinase inhibitors. The journal of pharmacology and experimental therapeutics, 321 (2). pp. 734-42. ISSN 0022-3565

IL-6

Holden, Neil S. and Gong, W. and King, E. M. and Kaur, M. and Giembycz, M. A. and Newton, R. (2007) Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. British journal of pharmacology, 152 (6). pp. 891-902. ISSN 0007-1188

Holden, Neil S. and Rider, C. F. and Bell, M. J. and Velayudhan, J. and King, E. M. and Kaur, M. and Salmon, M. and Giembycz, M. A. and Newton, R. (2010) Enhancement of inflammatory mediator release by beta(2)-adrenoceptor agonists in airway epithelial cells is reversed by glucocorticoid action. British journal of pharmacology, 160 (2). pp. 410-420. ISSN 0007-1188

IL-8

Catley, Matthew C. and Chivers, Joanna E. and Holden, Neil S. and Barnes, Peter J. and Newton, Robert (2005) Validation of IKK beta as therapeutic target in airway inflammatory disease by adenoviral-mediated delivery of dominant-negative IKK beta to pulmonary epithelial cells. British journal of pharmacology, 145 (1). pp. 114-22. ISSN 0007-1188

Holden, Neil S. and Gong, W. and King, E. M. and Kaur, M. and Giembycz, M. A. and Newton, R. (2007) Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. British journal of pharmacology, 152 (6). pp. 891-902. ISSN 0007-1188

Holden, Neil S. and Rider, C. F. and Bell, M. J. and Velayudhan, J. and King, E. M. and Kaur, M. and Salmon, M. and Giembycz, M. A. and Newton, R. (2010) Enhancement of inflammatory mediator release by beta(2)-adrenoceptor agonists in airway epithelial cells is reversed by glucocorticoid action. British journal of pharmacology, 160 (2). pp. 410-420. ISSN 0007-1188

Imidazoles

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

Immunohistochemistry

Simonyi, Agnes and Ngomba, Richard T. and Storto, Marianna and Catania, Maria V. and Miller, Laura A. and Youngs, Brian and DiGorgi-Gerevini, Valeria and Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

In Vitro

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Indoles

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Infarction, Middle Cerebral Artery

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Inflammation

Holden, Neil S. and Gong, W. and King, E. M. and Kaur, M. and Giembycz, M. A. and Newton, R. (2007) Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. British journal of pharmacology, 152 (6). pp. 891-902. ISSN 0007-1188

Holden, Neil S. and Rider, C. F. and Bell, M. J. and Velayudhan, J. and King, E. M. and Kaur, M. and Salmon, M. and Giembycz, M. A. and Newton, R. (2010) Enhancement of inflammatory mediator release by beta(2)-adrenoceptor agonists in airway epithelial cells is reversed by glucocorticoid action. British journal of pharmacology, 160 (2). pp. 410-420. ISSN 0007-1188

Injections, Intravenous

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Injections, Intraventricular

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Manahan-Vaughan, D. and Ngomba, Richard T. and Storto, M. and Kulla, A. and Catania, M. V. and Chiechio, S. and Rampello, L. and Passarelli, F. and Capece, A. and Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Intestinal Secretions

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Intestine, Large

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Ischemia

Kuroda, Satoshi and Katsura, Ken-ichiro and Hillered, Lars and Bates, Timothy E. and Siesjö, Bo K. (1996) Delayed treatment with alpha-phenyl-N-tert-butyl nitrone (PBN) attenuates secondary mitochondrial dysfunction after transient focal cerebral ischemia in the rat. Neurobiology of Disease, 3 (2). pp. 149-157. ISSN 0969-9961

Ischemic Attack, Transient

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Moyanova, S.G. and Kortenska, L.V. and Mitreva, R.G. and Pashova, V.D. and Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

Islets of Langerhans

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

Kainic Acid

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Ki-67 Antigen

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Kinetics

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Leukocytes, Mononuclear

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Ligands

Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Long-Term Potentiation

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Manahan-Vaughan, D. and Ngomba, Richard T. and Storto, M. and Kulla, A. and Catania, M. V. and Chiechio, S. and Rampello, L. and Passarelli, F. and Capece, A. and Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

MAP Kinase Signaling System

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

MTEP

D'Amore, V. and Santolini, I. and van Rijn, C.M. and Biagioni, F. and Molinaro, G. and Prete, A. and Conn, P.J. and Lindsley, C.W. and Zhou, Y. and Vinson, P.N. and Rodriguez, A.L. and Jones, C.K and Stauffer, S.R. and Nicoletti, F. and van Luijtelaar, G. and Ngomba, R.T. (2013) Potentiation of mGlu5 receptors with the novel enhancer, VU0360172, reduces spontaneous absence seizures in WAG/Rij rats. Neuropharmacology, 66 . pp. 330-338. ISSN 0028-3908

Magnetic Resonance Imaging

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Male

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Moyanova, S.G. and Kortenska, L.V. and Mitreva, R.G. and Pashova, V.D. and Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

Mepyramine

Holden, Neil S. and Gong, W. and King, E. M. and Kaur, M. and Giembycz, M. A. and Newton, R. (2007) Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. British journal of pharmacology, 152 (6). pp. 891-902. ISSN 0007-1188

Mice

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

Storto, Marianna and Ngomba, Richard T. and Battaglia, Giuseppe and Freitas, Isabel and Griffini, Patrizia and Richelmi, Plinio and Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

Mice, Inbred C57BL

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Mice, Inbred Strains

Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Mice, Knockout

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Mice, Nude

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Microdialysis

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Microscopy, Electron

Ngomba, Richard T. and Ferraguti, F. and Badura, A. and Citraro, R. and Santolini, I. and Battaglia, G. and Bruno, V. and De Sarro, G. and Simonyi, A. and van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Middle Aged

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Models, Molecular

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Molecular

Gruber, T. (2015) In the molecular cage: complexation of biologically active compounds. In: Invited Lecture hosted by the Institute of Pharmacology and Toxicology, January 2015, University of the German Armed Forces, Munich.

Molecular Targeted Therapy

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Morpholines

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Motor Activity

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Movement

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Munc18 Proteins

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Munc18 protein

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Muscle Contraction

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

NF-?B

Holden, Neil S. and Gong, W. and King, E. M. and Kaur, M. and Giembycz, M. A. and Newton, R. (2007) Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. British journal of pharmacology, 152 (6). pp. 891-902. ISSN 0007-1188

NF-kappa B

Catley, Matthew C. and Chivers, Joanna E. and Holden, Neil S. and Barnes, Peter J. and Newton, Robert (2005) Validation of IKK beta as therapeutic target in airway inflammatory disease by adenoviral-mediated delivery of dominant-negative IKK beta to pulmonary epithelial cells. British journal of pharmacology, 145 (1). pp. 114-22. ISSN 0007-1188

King, Elizabeth M. and Kaur, Manminder and Gong, Wei and Rider, Christopher F. and Holden, Neil S. and Newton, Robert (2009) Regulation of tristetraprolin expression by interleukin-1β and dexamethasone in human pulmonary epithelial cells: Roles for nuclear factor-κB and p38 mitogen-activated protein kinase. The journal of pharmacology and experimental therapeutics, 330 (2). pp. 575-585. ISSN 0022-3565

Newton, Robert and Holden, Neil S. and Catley, Matthew C. and Oyelusi, Wale and Leigh, Richard and Proud, David and Barnes, Peter J. (2007) Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IκB kinase inhibitors. The journal of pharmacology and experimental therapeutics, 321 (2). pp. 734-42. ISSN 0022-3565

NHBE

Holden, Neil S. and Rider, C. F. and Bell, M. J. and Velayudhan, J. and King, E. M. and Kaur, M. and Salmon, M. and Giembycz, M. A. and Newton, R. (2010) Enhancement of inflammatory mediator release by beta(2)-adrenoceptor agonists in airway epithelial cells is reversed by glucocorticoid action. British journal of pharmacology, 160 (2). pp. 410-420. ISSN 0007-1188

Naphthalenes

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Neoplastic Stem Cells

Nicoletti, F. and Battaglia, G. and Storto, M. and Ngomba, Richard T. and Iacovelli, L. and Arcella, A. and Gradini, R. and Sale, P. and Rampello, L. and De Vita, T. and Di Marco, R. and Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

Nerve Net

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Nervous System Physiology

Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Neural Pathways

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Neuroglia

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Neuroprotective Agents

Moyanova, S.G. and Kortenska, L.V. and Mitreva, R.G. and Pashova, V.D. and Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

Nucleic Acid Synthesis Inhibitors

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Osteoblasts

Nicoletti, F. and Battaglia, G. and Storto, M. and Ngomba, Richard T. and Iacovelli, L. and Arcella, A. and Gradini, R. and Sale, P. and Rampello, L. and De Vita, T. and Di Marco, R. and Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

Oxazines

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

PBN

Kuroda, Satoshi and Katsura, Ken-ichiro and Hillered, Lars and Bates, Timothy E. and Siesjö, Bo K. (1996) Delayed treatment with alpha-phenyl-N-tert-butyl nitrone (PBN) attenuates secondary mitochondrial dysfunction after transient focal cerebral ischemia in the rat. Neurobiology of Disease, 3 (2). pp. 149-157. ISSN 0969-9961

Pancreas

Nicoletti, F. and Battaglia, G. and Storto, M. and Ngomba, Richard T. and Iacovelli, L. and Arcella, A. and Gradini, R. and Sale, P. and Rampello, L. and De Vita, T. and Di Marco, R. and Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

Parkinson disease

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Pentylenetetrazole

Ngomba, Richard T. and Ferraguti, F. and Badura, A. and Citraro, R. and Santolini, I. and Battaglia, G. and Bruno, V. and De Sarro, G. and Simonyi, A. and van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Perforant Pathway

Manahan-Vaughan, D. and Ngomba, Richard T. and Storto, M. and Kulla, A. and Catania, M. V. and Chiechio, S. and Rampello, L. and Passarelli, F. and Capece, A. and Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Perfusion

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Phenazopyridine

Storto, Marianna and Ngomba, Richard T. and Battaglia, Giuseppe and Freitas, Isabel and Griffini, Patrizia and Richelmi, Plinio and Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

Phosphatidylinositol Phosphates

Cinque, C. and Zuena, A .R. and Casolini, P. and Ngomba, Richard T. and Melchiorri, D. and Maccari, S. and Nicoletti, F. and Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Phosphinic Acids

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Photosensitizing Agents

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Piperidines

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Polyunsaturated Alkamides

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Postural Balance

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Pregnancy

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Prenatal Exposure Delayed Effects

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Psychomotor Performance

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Pulmonary epithelium

Catley, Matthew C. and Chivers, Joanna E. and Holden, Neil S. and Barnes, Peter J. and Newton, Robert (2005) Validation of IKK beta as therapeutic target in airway inflammatory disease by adenoviral-mediated delivery of dominant-negative IKK beta to pulmonary epithelial cells. British journal of pharmacology, 145 (1). pp. 114-22. ISSN 0007-1188

Purkinje cell

Simonyi, Agnes and Ngomba, Richard T. and Storto, Marianna and Catania, Maria V. and Miller, Laura A. and Youngs, Brian and DiGorgi-Gerevini, Valeria and Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

Pyrazoles

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Pyridines

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Storto, Marianna and Ngomba, Richard T. and Battaglia, Giuseppe and Freitas, Isabel and Griffini, Patrizia and Richelmi, Plinio and Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

Quinolines

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

R-SNARE Proteins

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

RANTES

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

RANTES, allergic encephalitis

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

RNA, Messenger

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Granata, Filippo and Potenza, Rossella Luisa and Fiori, Anna and Strom, Roberto and Caronti, Brunella and Molinari, Paola and Donsante, Sonia and Citro, Gennaro and Iacovelli, Luisa and De Blasi, Antonio and Ngomba, Richard T. and Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

Manahan-Vaughan, D. and Ngomba, Richard T. and Storto, M. and Kulla, A. and Catania, M. V. and Chiechio, S. and Rampello, L. and Passarelli, F. and Capece, A. and Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Simonyi, Agnes and Ngomba, Richard T. and Storto, Marianna and Catania, Maria V. and Miller, Laura A. and Youngs, Brian and DiGorgi-Gerevini, Valeria and Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

RO0711401

D'Amore, V. and Santolini, I. and Celli, R. and Lionetto, L. and De Fusco, A. and Simmaco, M. and van Rijn, C. M. and Vieira, E. and Stauffer, S.R. and Conn, P. J. and Bosco, P. and Nicoletti, F. and van Luijtelaar, G. and Ngomba, R. T. (2014) Head-to head comparison of mGlu1 and mGlu5 receptor activation in chronic treatment of absence epilepsy in WAG/Rij rats. Neuropharmacology, 85 . pp. 91-103. ISSN 0028-3908

Rab protein

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Rats

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Cinque, C. and Zuena, A .R. and Casolini, P. and Ngomba, Richard T. and Melchiorri, D. and Maccari, S. and Nicoletti, F. and Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Granata, Filippo and Potenza, Rossella Luisa and Fiori, Anna and Strom, Roberto and Caronti, Brunella and Molinari, Paola and Donsante, Sonia and Citro, Gennaro and Iacovelli, Luisa and De Blasi, Antonio and Ngomba, Richard T. and Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

Manahan-Vaughan, D. and Ngomba, Richard T. and Storto, M. and Kulla, A. and Catania, M. V. and Chiechio, S. and Rampello, L. and Passarelli, F. and Capece, A. and Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Matrisciano, F. and Storto, M. and Ngomba, Richard T. and Cappuccio, I. and Caricasole, A. and Scaccianoce, S. and Riozzi, B. and Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Moyanova, S.G. and Kortenska, L.V. and Mitreva, R.G. and Pashova, V.D. and Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard T. and Ferraguti, F. and Badura, A. and Citraro, R. and Santolini, I. and Battaglia, G. and Bruno, V. and De Sarro, G. and Simonyi, A. and van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Simonyi, Agnes and Ngomba, Richard T. and Storto, Marianna and Catania, Maria V. and Miller, Laura A. and Youngs, Brian and DiGorgi-Gerevini, Valeria and Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

Storto, Marianna and Ngomba, Richard T. and Battaglia, Giuseppe and Freitas, Isabel and Griffini, Patrizia and Richelmi, Plinio and Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Rats, Inbred ACI

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Rats, Inbred F344

Simonyi, Agnes and Ngomba, Richard T. and Storto, Marianna and Catania, Maria V. and Miller, Laura A. and Youngs, Brian and DiGorgi-Gerevini, Valeria and Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

Rats, Inbred Lew

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Rats, Inbred Strains

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Rats, Mutant Strains

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Rats, Sprague-Dawley

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Granata, Filippo and Potenza, Rossella Luisa and Fiori, Anna and Strom, Roberto and Caronti, Brunella and Molinari, Paola and Donsante, Sonia and Citro, Gennaro and Iacovelli, Luisa and De Blasi, Antonio and Ngomba, Richard T. and Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Matrisciano, F. and Storto, M. and Ngomba, Richard T. and Cappuccio, I. and Caricasole, A. and Scaccianoce, S. and Riozzi, B. and Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

Ngomba, Richard T. and Ferraguti, F. and Badura, A. and Citraro, R. and Santolini, I. and Battaglia, G. and Bruno, V. and De Sarro, G. and Simonyi, A. and van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Rats, Wistar

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Cinque, C. and Zuena, A .R. and Casolini, P. and Ngomba, Richard T. and Melchiorri, D. and Maccari, S. and Nicoletti, F. and Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Manahan-Vaughan, D. and Ngomba, Richard T. and Storto, M. and Kulla, A. and Catania, M. V. and Chiechio, S. and Rampello, L. and Passarelli, F. and Capece, A. and Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Moyanova, S.G. and Kortenska, L.V. and Mitreva, R.G. and Pashova, V.D. and Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Storto, Marianna and Ngomba, Richard T. and Battaglia, Giuseppe and Freitas, Isabel and Griffini, Patrizia and Richelmi, Plinio and Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

Rattus

Moyanova, S.G. and Kortenska, L.V. and Mitreva, R.G. and Pashova, V.D. and Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

Reaction Time

Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Receptor, Cannabinoid, CB1

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Receptors, Adrenergic, beta

Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Receptors, Drug

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

Receptors, Metabotropic Glutamate

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Cinque, C. and Zuena, A .R. and Casolini, P. and Ngomba, Richard T. and Melchiorri, D. and Maccari, S. and Nicoletti, F. and Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Manahan-Vaughan, D. and Ngomba, Richard T. and Storto, M. and Kulla, A. and Catania, M. V. and Chiechio, S. and Rampello, L. and Passarelli, F. and Capece, A. and Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Matrisciano, F. and Storto, M. and Ngomba, Richard T. and Cappuccio, I. and Caricasole, A. and Scaccianoce, S. and Riozzi, B. and Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard T. and Ferraguti, F. and Badura, A. and Citraro, R. and Santolini, I. and Battaglia, G. and Bruno, V. and De Sarro, G. and Simonyi, A. and van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Nicoletti, F. and Battaglia, G. and Storto, M. and Ngomba, Richard T. and Iacovelli, L. and Arcella, A. and Gradini, R. and Sale, P. and Rampello, L. and De Vita, T. and Di Marco, R. and Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Simonyi, Agnes and Ngomba, Richard T. and Storto, Marianna and Catania, Maria V. and Miller, Laura A. and Youngs, Brian and DiGorgi-Gerevini, Valeria and Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

Storto, Marianna and Ngomba, Richard T. and Battaglia, Giuseppe and Freitas, Isabel and Griffini, Patrizia and Richelmi, Plinio and Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

Receptors, Opioid

Granata, Filippo and Potenza, Rossella Luisa and Fiori, Anna and Strom, Roberto and Caronti, Brunella and Molinari, Paola and Donsante, Sonia and Citro, Gennaro and Iacovelli, Luisa and De Blasi, Antonio and Ngomba, Richard T. and Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

Reflex

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Reverse Transcriptase Polymerase Chain Reaction

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Chivers, Joanna E. and Gong, Wei and King, Elizabeth M. and Seybold, Joachim and Mak, Judith C. and Donnelly, Louise E. and Holden, Neil S. and Newton, Robert (2006) Analysis of the dissociated steroid RU24858 does not exclude a role for inducible genes in the anti-inflammatory actions of glucocorticoids. Molecular pharmacology, 70 (6). pp. 2084-2095. ISSN 0026-895X

Rimonabant

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Seizure

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Seizures

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Severity of Illness Index

Moyanova, S.G. and Kortenska, L.V. and Mitreva, R.G. and Pashova, V.D. and Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

Signal Transduction

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

Smooth muscle cells

Kelly, M. M. and King, E. M. and Rider, C. F. and Gwozd, C. and Holden, Neil S. and Eddleston, J. and Zuraw, B. and Leigh, R. and O'Byrne, P. M. and Newton, R. (2012) Corticosteroid-induced gene expression in allergen-challenged asthmatic subjects taking inhaled budesonide. British Journal of Pharmacology, 165 (6). pp. 1737-1747. ISSN 0007-1188

Somatosensory Cortex

Moyanova, S.G. and Kortenska, L.V. and Mitreva, R.G. and Pashova, V.D. and Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

Spike-wave discharges

D'Amore, V. and Santolini, I. and Celli, R. and Lionetto, L. and De Fusco, A. and Simmaco, M. and van Rijn, C. M. and Vieira, E. and Stauffer, S.R. and Conn, P. J. and Bosco, P. and Nicoletti, F. and van Luijtelaar, G. and Ngomba, R. T. (2014) Head-to head comparison of mGlu1 and mGlu5 receptor activation in chronic treatment of absence epilepsy in WAG/Rij rats. Neuropharmacology, 85 . pp. 91-103. ISSN 0028-3908

Spinocerebellar Ataxias

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Spinocerebellar Ataxias, Animals

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Sprague Dawley rat

Ngomba, Richard T. and Ferraguti, F. and Badura, A. and Citraro, R. and Santolini, I. and Battaglia, G. and Bruno, V. and De Sarro, G. and Simonyi, A. and van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Stress, Psychological

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Supersensitivity

HAWTHORN, M. H. and CHESSWILLIAMS, R. G. and Grassby, P. F. and BROADLEY, K. J. (1985) The use of forskolin to investigate the site of cardiac beta-adrenoreceptor supersensitivity. Journal of Autonomic Pharmacology, 5 (3). pp. 231-239. ISSN 0144-1795

Synapses

Manahan-Vaughan, D. and Ngomba, Richard T. and Storto, M. and Kulla, A. and Catania, M. V. and Chiechio, S. and Rampello, L. and Passarelli, F. and Capece, A. and Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Synapsins

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Synaptic Transmission

Manahan-Vaughan, D. and Ngomba, Richard T. and Storto, M. and Kulla, A. and Catania, M. V. and Chiechio, S. and Rampello, L. and Passarelli, F. and Capece, A. and Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Nicoletti, F. and Battaglia, G. and Storto, M. and Ngomba, Richard T. and Iacovelli, L. and Arcella, A. and Gradini, R. and Sale, P. and Rampello, L. and De Vita, T. and Di Marco, R. and Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

T lymphocyte, Animals

Nicoletti, F. and Battaglia, G. and Storto, M. and Ngomba, Richard T. and Iacovelli, L. and Arcella, A. and Gradini, R. and Sale, P. and Rampello, L. and De Vita, T. and Di Marco, R. and Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

Tetrazolium Salts, Animalia

Moyanova, S.G. and Kortenska, L.V. and Mitreva, R.G. and Pashova, V.D. and Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

Thalamic Nuclei

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Thalamus

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Tissue Fixation

Ngomba, Richard T. and Ferraguti, F. and Badura, A. and Citraro, R. and Santolini, I. and Battaglia, G. and Bruno, V. and De Sarro, G. and Simonyi, A. and van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Tolerance

D'Amore, V. and Santolini, I. and Celli, R. and Lionetto, L. and De Fusco, A. and Simmaco, M. and van Rijn, C. M. and Vieira, E. and Stauffer, S.R. and Conn, P. J. and Bosco, P. and Nicoletti, F. and van Luijtelaar, G. and Ngomba, R. T. (2014) Head-to head comparison of mGlu1 and mGlu5 receptor activation in chronic treatment of absence epilepsy in WAG/Rij rats. Neuropharmacology, 85 . pp. 91-103. ISSN 0028-3908

Transactivation

Newton, Robert and Holden, Neil S. (2007) Separating transrepression and transactivation: a distressing divorce for the glucocorticoid receptor? Molecular pharmacology, 72 (4). pp. 799-809. ISSN 0026-895X

Transcription

Chivers, Joanna E. and Gong, Wei and King, Elizabeth M. and Seybold, Joachim and Mak, Judith C. and Donnelly, Louise E. and Holden, Neil S. and Newton, Robert (2006) Analysis of the dissociated steroid RU24858 does not exclude a role for inducible genes in the anti-inflammatory actions of glucocorticoids. Molecular pharmacology, 70 (6). pp. 2084-2095. ISSN 0026-895X

Up-Regulation

Matrisciano, F. and Storto, M. and Ngomba, Richard T. and Cappuccio, I. and Caricasole, A. and Scaccianoce, S. and Riozzi, B. and Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

VU0360172

D'Amore, V. and Santolini, I. and Celli, R. and Lionetto, L. and De Fusco, A. and Simmaco, M. and van Rijn, C. M. and Vieira, E. and Stauffer, S.R. and Conn, P. J. and Bosco, P. and Nicoletti, F. and van Luijtelaar, G. and Ngomba, R. T. (2014) Head-to head comparison of mGlu1 and mGlu5 receptor activation in chronic treatment of absence epilepsy in WAG/Rij rats. Neuropharmacology, 85 . pp. 91-103. ISSN 0028-3908

D'Amore, V. and Santolini, I. and van Rijn, C.M. and Biagioni, F. and Molinaro, G. and Prete, A. and Conn, P.J. and Lindsley, C.W. and Zhou, Y. and Vinson, P.N. and Rodriguez, A.L. and Jones, C.K and Stauffer, S.R. and Nicoletti, F. and van Luijtelaar, G. and Ngomba, R.T. (2013) Potentiation of mGlu5 receptors with the novel enhancer, VU0360172, reduces spontaneous absence seizures in WAG/Rij rats. Neuropharmacology, 66 . pp. 330-338. ISSN 0028-3908

WAG/Rij rats

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

D'Amore, V. and Santolini, I. and Celli, R. and Lionetto, L. and De Fusco, A. and Simmaco, M. and van Rijn, C. M. and Vieira, E. and Stauffer, S.R. and Conn, P. J. and Bosco, P. and Nicoletti, F. and van Luijtelaar, G. and Ngomba, R. T. (2014) Head-to head comparison of mGlu1 and mGlu5 receptor activation in chronic treatment of absence epilepsy in WAG/Rij rats. Neuropharmacology, 85 . pp. 91-103. ISSN 0028-3908

D'Amore, V. and Santolini, I. and van Rijn, C.M. and Biagioni, F. and Molinaro, G. and Prete, A. and Conn, P.J. and Lindsley, C.W. and Zhou, Y. and Vinson, P.N. and Rodriguez, A.L. and Jones, C.K and Stauffer, S.R. and Nicoletti, F. and van Luijtelaar, G. and Ngomba, R.T. (2013) Potentiation of mGlu5 receptors with the novel enhancer, VU0360172, reduces spontaneous absence seizures in WAG/Rij rats. Neuropharmacology, 66 . pp. 330-338. ISSN 0028-3908

WIN55,212, Animals

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Western blotting

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Western blotting, 2-Amino-5-phosphonovalerate

Manahan-Vaughan, D. and Ngomba, Richard T. and Storto, M. and Kulla, A. and Catania, M. V. and Chiechio, S. and Rampello, L. and Passarelli, F. and Capece, A. and Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Western blotting, Age Factors

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Western blotting, Aging

Simonyi, Agnes and Ngomba, Richard T. and Storto, Marianna and Catania, Maria V. and Miller, Laura A. and Youngs, Brian and DiGorgi-Gerevini, Valeria and Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

Western blotting, Amino Acids

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Western blotting, Animals

Cinque, C. and Zuena, A .R. and Casolini, P. and Ngomba, Richard T. and Melchiorri, D. and Maccari, S. and Nicoletti, F. and Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Wistar albino Glaxo rat

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Wistar albino Glaxo rat, Animals

Ngomba, Richard T. and Ferraguti, F. and Badura, A. and Citraro, R. and Santolini, I. and Battaglia, G. and Bruno, V. and De Sarro, G. and Simonyi, A. and van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Wistar rat, Allosteric Regulation

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Xanthenes

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

absence

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

acetylcysteine

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

adenosine triphosphatase (potassium)

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

adolescent

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

adult

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

aging

Simonyi, Agnes and Ngomba, Richard T. and Storto, Marianna and Catania, Maria V. and Miller, Laura A. and Youngs, Brian and DiGorgi-Gerevini, Valeria and Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

agmatine

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

algorithm

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

alpha 1 adrenergic receptor blocking agent

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

alpha ethylglutamate

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

alpha methyl 4 tetrazolylphenylglycine

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

alpha methylserine o phosphate

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

amantadine

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

amenamevir

Biswas, Subhajit and Sukla, Soumi and Field, Hugh J. (2014) Helicase-primase inhibitors for herpes simplex virus: looking to the future of non-nucleoside inhibitors for treating herpes virus infections. Future Medicinal Chemistry, 6 (1). pp. 45-55. ISSN 1756-8919

amide

Ngomba, Richard T. and Ferraguti, F. and Badura, A. and Citraro, R. and Santolini, I. and Battaglia, G. and Bruno, V. and De Sarro, G. and Simonyi, A. and van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

amino acid receptor blocking agent

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

aminolevulinic acid

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

aminolevulinic acid hexyl ester

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

analysis of variance

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

anandamide

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

animal

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

animal cell

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

animal experiment

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard T. and Ferraguti, F. and Badura, A. and Citraro, R. and Santolini, I. and Battaglia, G. and Bruno, V. and De Sarro, G. and Simonyi, A. and van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Storto, Marianna and Ngomba, Richard T. and Battaglia, Giuseppe and Freitas, Isabel and Griffini, Patrizia and Richelmi, Plinio and Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

animal model

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard T. and Ferraguti, F. and Badura, A. and Citraro, R. and Santolini, I. and Battaglia, G. and Bruno, V. and De Sarro, G. and Simonyi, A. and van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Storto, Marianna and Ngomba, Richard T. and Battaglia, Giuseppe and Freitas, Isabel and Griffini, Patrizia and Richelmi, Plinio and Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

animal tissue

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Cinque, C. and Zuena, A .R. and Casolini, P. and Ngomba, Richard T. and Melchiorri, D. and Maccari, S. and Nicoletti, F. and Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Granata, Filippo and Potenza, Rossella Luisa and Fiori, Anna and Strom, Roberto and Caronti, Brunella and Molinari, Paola and Donsante, Sonia and Citro, Gennaro and Iacovelli, Luisa and De Blasi, Antonio and Ngomba, Richard T. and Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

Manahan-Vaughan, D. and Ngomba, Richard T. and Storto, M. and Kulla, A. and Catania, M. V. and Chiechio, S. and Rampello, L. and Passarelli, F. and Capece, A. and Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard T. and Ferraguti, F. and Badura, A. and Citraro, R. and Santolini, I. and Battaglia, G. and Bruno, V. and De Sarro, G. and Simonyi, A. and van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Simonyi, Agnes and Ngomba, Richard T. and Storto, Marianna and Catania, Maria V. and Miller, Laura A. and Youngs, Brian and DiGorgi-Gerevini, Valeria and Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

Storto, Marianna and Ngomba, Richard T. and Battaglia, Giuseppe and Freitas, Isabel and Griffini, Patrizia and Richelmi, Plinio and Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

anti-inflammatories

Newton, Robert and Holden, Neil S. (2007) Separating transrepression and transactivation: a distressing divorce for the glucocorticoid receptor? Molecular pharmacology, 72 (4). pp. 799-809. ISSN 0026-895X

anti-inflammatory effects

Chivers, Joanna E. and Gong, Wei and King, Elizabeth M. and Seybold, Joachim and Mak, Judith C. and Donnelly, Louise E. and Holden, Neil S. and Newton, Robert (2006) Analysis of the dissociated steroid RU24858 does not exclude a role for inducible genes in the anti-inflammatory actions of glucocorticoids. Molecular pharmacology, 70 (6). pp. 2084-2095. ISSN 0026-895X

antibiotics

Gruber, T. (2011) Sensor active molecules and antibiotics. In: Invited Lecture, January 2011, Hungarian Academy of Science, Budapest (Hungary),.

antidepressant activity

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

antidepressant agent

Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

antiestrogen

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

antineoplastic activity

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

antiviral

Biswas, Subhajit and Sukla, Soumi and Field, Hugh J. (2014) Helicase-primase inhibitors for herpes simplex virus: looking to the future of non-nucleoside inhibitors for treating herpes virus infections. Future Medicinal Chemistry, 6 (1). pp. 45-55. ISSN 1756-8919

anxiety

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

aorta

Granata, Filippo and Potenza, Rossella Luisa and Fiori, Anna and Strom, Roberto and Caronti, Brunella and Molinari, Paola and Donsante, Sonia and Citro, Gennaro and Iacovelli, Luisa and De Blasi, Antonio and Ngomba, Richard T. and Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

area under the curve

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

article

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Cinque, C. and Zuena, A .R. and Casolini, P. and Ngomba, Richard T. and Melchiorri, D. and Maccari, S. and Nicoletti, F. and Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Granata, Filippo and Potenza, Rossella Luisa and Fiori, Anna and Strom, Roberto and Caronti, Brunella and Molinari, Paola and Donsante, Sonia and Citro, Gennaro and Iacovelli, Luisa and De Blasi, Antonio and Ngomba, Richard T. and Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Manahan-Vaughan, D. and Ngomba, Richard T. and Storto, M. and Kulla, A. and Catania, M. V. and Chiechio, S. and Rampello, L. and Passarelli, F. and Capece, A. and Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Matrisciano, F. and Storto, M. and Ngomba, Richard T. and Cappuccio, I. and Caricasole, A. and Scaccianoce, S. and Riozzi, B. and Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard T. and Ferraguti, F. and Badura, A. and Citraro, R. and Santolini, I. and Battaglia, G. and Bruno, V. and De Sarro, G. and Simonyi, A. and van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Nicoletti, F. and Battaglia, G. and Storto, M. and Ngomba, Richard T. and Iacovelli, L. and Arcella, A. and Gradini, R. and Sale, P. and Rampello, L. and De Vita, T. and Di Marco, R. and Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

Simonyi, Agnes and Ngomba, Richard T. and Storto, Marianna and Catania, Maria V. and Miller, Laura A. and Youngs, Brian and DiGorgi-Gerevini, Valeria and Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

Storto, Marianna and Ngomba, Richard T. and Battaglia, Giuseppe and Freitas, Isabel and Griffini, Patrizia and Richelmi, Plinio and Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

astrocyte

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

attenuation

Cinque, C. and Zuena, A .R. and Casolini, P. and Ngomba, Richard T. and Melchiorri, D. and Maccari, S. and Nicoletti, F. and Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

atypical antipsychotic agent

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

autism

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

azd 2066

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

basimglurant

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

behavior

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

benzoxazine derivative

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

beta adrenergic receptor

Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

beta-agonists

Chess-Williams, RG and Grassby, Paul and Culling, W. and Penny, W. and Broadley, K. J. and Sheridan, D. J. (1985) Cardiac postjunctional supersensitivity to β-agonists after chronic chemical sympathectomy with 6-hydroxydopamine. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 329 (2). pp. 162-166. ISSN 0028-1298

beta2-adrenoceptor agonists

Holden, Neil S. and Rider, C. F. and Bell, M. J. and Velayudhan, J. and King, E. M. and Kaur, M. and Salmon, M. and Giembycz, M. A. and Newton, R. (2010) Enhancement of inflammatory mediator release by beta(2)-adrenoceptor agonists in airway epithelial cells is reversed by glucocorticoid action. British journal of pharmacology, 160 (2). pp. 410-420. ISSN 0007-1188

Rider, Christopher F. and King, Elizabeth M. and Holden, Neil S. and Giembycz, Mark A. and Newton, Robert (2011) Inflammatory stimuli inhibit glucocorticoid-dependent transactivation in human pulmonary epithelial cells: rescue by long-acting beta2-adrenoceptor agonists. Journal of Pharmacology and Experimental Therapeutics, 338 (3). pp. 860-869. ISSN 0022-3565

bioavailability

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

blood

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

body posture

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

brain

Simonyi, Agnes and Ngomba, Richard T. and Storto, Marianna and Catania, Maria V. and Miller, Laura A. and Youngs, Brian and DiGorgi-Gerevini, Valeria and Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

brain blood vessel

Granata, Filippo and Potenza, Rossella Luisa and Fiori, Anna and Strom, Roberto and Caronti, Brunella and Molinari, Paola and Donsante, Sonia and Citro, Gennaro and Iacovelli, Luisa and De Blasi, Antonio and Ngomba, Richard T. and Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

brain capillary

Granata, Filippo and Potenza, Rossella Luisa and Fiori, Anna and Strom, Roberto and Caronti, Brunella and Molinari, Paola and Donsante, Sonia and Citro, Gennaro and Iacovelli, Luisa and De Blasi, Antonio and Ngomba, Richard T. and Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

brain cortex

Matrisciano, F. and Storto, M. and Ngomba, Richard T. and Cappuccio, I. and Caricasole, A. and Scaccianoce, S. and Riozzi, B. and Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

brain damage

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

brain depth stimulation

Manahan-Vaughan, D. and Ngomba, Richard T. and Storto, M. and Kulla, A. and Catania, M. V. and Chiechio, S. and Rampello, L. and Passarelli, F. and Capece, A. and Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

brain infarction size

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

brain ischemia

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

Moyanova, S.G. and Kortenska, L.V. and Mitreva, R.G. and Pashova, V.D. and Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

brain level

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

brain protection

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

brain protein

Matrisciano, F. and Storto, M. and Ngomba, Richard T. and Cappuccio, I. and Caricasole, A. and Scaccianoce, S. and Riozzi, B. and Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

brain region

Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Simonyi, Agnes and Ngomba, Richard T. and Storto, Marianna and Catania, Maria V. and Miller, Laura A. and Youngs, Brian and DiGorgi-Gerevini, Valeria and Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

brain slice

Cinque, C. and Zuena, A .R. and Casolini, P. and Ngomba, Richard T. and Melchiorri, D. and Maccari, S. and Nicoletti, F. and Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Matrisciano, F. and Storto, M. and Ngomba, Richard T. and Cappuccio, I. and Caricasole, A. and Scaccianoce, S. and Riozzi, B. and Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

brain tumor

Nicoletti, F. and Battaglia, G. and Storto, M. and Ngomba, Richard T. and Iacovelli, L. and Arcella, A. and Gradini, R. and Sale, P. and Rampello, L. and De Vita, T. and Di Marco, R. and Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

calcium cell level

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

calcium ion

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

calcium transport

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

calixarenes

Gruber, T. (2005) Synthesis, structures and inclusion behaviour of functionalized calixarenes. In: ., October 2005, Department of Natural Sciences, University of Chemnitz (Germany).

cancer cell culture

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

cancer graft

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

cancer growth

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

cancer inhibition

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

cannabinoid 1 receptor

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

cannabinoid 1 receptor agonist

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

cannabis addiction

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

carbon

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

carbon 14

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

caudate nucleus

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

cell culture

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Granata, Filippo and Potenza, Rossella Luisa and Fiori, Anna and Strom, Roberto and Caronti, Brunella and Molinari, Paola and Donsante, Sonia and Citro, Gennaro and Iacovelli, Luisa and De Blasi, Antonio and Ngomba, Richard T. and Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

cell death

Storto, Marianna and Ngomba, Richard T. and Battaglia, Giuseppe and Freitas, Isabel and Griffini, Patrizia and Richelmi, Plinio and Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

cell proliferation

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

cellular distribution

Ngomba, Richard T. and Ferraguti, F. and Badura, A. and Citraro, R. and Santolini, I. and Battaglia, G. and Bruno, V. and De Sarro, G. and Simonyi, A. and van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

central nervous system

Nicoletti, F. and Battaglia, G. and Storto, M. and Ngomba, Richard T. and Iacovelli, L. and Arcella, A. and Gradini, R. and Sale, P. and Rampello, L. and De Vita, T. and Di Marco, R. and Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

central nervous system disease

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

cerebellum

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

cerebellum disease

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

cerebrovascular accident

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

chemical binding

Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

chemistry

Gruber, T. (2014) The chemistry of X-mas. In: JCF Christmas Lecture, December 2014, University of Cologne (Germany).

cinnabarinic acid

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

clinical trial

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

cocaine dependence

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

compounds

Gruber, T. (2015) In the molecular cage: complexation of biologically active compounds. In: Invited Lecture hosted by the Institute of Pharmacology and Toxicology, January 2015, University of the German Armed Forces, Munich.

concentration response

Matrisciano, F. and Storto, M. and Ngomba, Richard T. and Cappuccio, I. and Caricasole, A. and Scaccianoce, S. and Riozzi, B. and Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

conference paper

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

confidence interval

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

controlled clinical trial

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

controlled study

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Cinque, C. and Zuena, A .R. and Casolini, P. and Ngomba, Richard T. and Melchiorri, D. and Maccari, S. and Nicoletti, F. and Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Granata, Filippo and Potenza, Rossella Luisa and Fiori, Anna and Strom, Roberto and Caronti, Brunella and Molinari, Paola and Donsante, Sonia and Citro, Gennaro and Iacovelli, Luisa and De Blasi, Antonio and Ngomba, Richard T. and Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Manahan-Vaughan, D. and Ngomba, Richard T. and Storto, M. and Kulla, A. and Catania, M. V. and Chiechio, S. and Rampello, L. and Passarelli, F. and Capece, A. and Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Matrisciano, F. and Storto, M. and Ngomba, Richard T. and Cappuccio, I. and Caricasole, A. and Scaccianoce, S. and Riozzi, B. and Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

Moyanova, S.G. and Kortenska, L.V. and Mitreva, R.G. and Pashova, V.D. and Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard T. and Ferraguti, F. and Badura, A. and Citraro, R. and Santolini, I. and Battaglia, G. and Bruno, V. and De Sarro, G. and Simonyi, A. and van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

Simonyi, Agnes and Ngomba, Richard T. and Storto, Marianna and Catania, Maria V. and Miller, Laura A. and Youngs, Brian and DiGorgi-Gerevini, Valeria and Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

Storto, Marianna and Ngomba, Richard T. and Battaglia, Giuseppe and Freitas, Isabel and Griffini, Patrizia and Richelmi, Plinio and Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

convalescence

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

corpus callosum

Simonyi, Agnes and Ngomba, Richard T. and Storto, Marianna and Catania, Maria V. and Miller, Laura A. and Youngs, Brian and DiGorgi-Gerevini, Valeria and Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

corpus striatum

Matrisciano, F. and Storto, M. and Ngomba, Richard T. and Cappuccio, I. and Caricasole, A. and Scaccianoce, S. and Riozzi, B. and Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

corticosteroid

Cinque, C. and Zuena, A .R. and Casolini, P. and Ngomba, Richard T. and Melchiorri, D. and Maccari, S. and Nicoletti, F. and Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

crossover procedure

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

culture medium

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

cyclic AMP

Matrisciano, F. and Storto, M. and Ngomba, Richard T. and Cappuccio, I. and Caricasole, A. and Scaccianoce, S. and Riozzi, B. and Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

cyclin D1

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

cyclin D2

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

cytochrome P450 3A4

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

cytokines

Catley, Matthew C. and Chivers, Joanna E. and Holden, Neil S. and Barnes, Peter J. and Newton, Robert (2005) Validation of IKK beta as therapeutic target in airway inflammatory disease by adenoviral-mediated delivery of dominant-negative IKK beta to pulmonary epithelial cells. British journal of pharmacology, 145 (1). pp. 114-22. ISSN 0007-1188

data analysis

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

dentate gyrus

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Manahan-Vaughan, D. and Ngomba, Richard T. and Storto, M. and Kulla, A. and Catania, M. V. and Chiechio, S. and Rampello, L. and Passarelli, F. and Capece, A. and Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

depolarization

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

depression

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

desipramine

Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

dexamethasones

King, Elizabeth M. and Kaur, Manminder and Gong, Wei and Rider, Christopher F. and Holden, Neil S. and Newton, Robert (2009) Regulation of tristetraprolin expression by interleukin-1β and dexamethasone in human pulmonary epithelial cells: Roles for nuclear factor-κB and p38 mitogen-activated protein kinase. The journal of pharmacology and experimental therapeutics, 330 (2). pp. 575-585. ISSN 0022-3565

dextro aspartic acid

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

diabetes mellitus

Siriwardena, A. Niroshan and Middlemass, Jo B. and Ward, Kate and Wilkinson, Carol (2009) Drivers for change in primary care of diabetes following a protected learning time educational event: interview study of practitioners. BMC Medical Education, 8 (4). pp. 1-9. ISSN 1472-6920

dialysate

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

diazepam

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

diazoxide

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

dihydroxyphenylglycine

Matrisciano, F. and Storto, M. and Ngomba, Richard T. and Cappuccio, I. and Caricasole, A. and Scaccianoce, S. and Riozzi, B. and Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

dipraglurant

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

disease model

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

disease severity

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

dizocilpine

Moyanova, S.G. and Kortenska, L.V. and Mitreva, R.G. and Pashova, V.D. and Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

dose calculation

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

dose response

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

dose time effect relation

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

down regulation

Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

drug absorption

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

drug administration route

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

drug antagonism

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

drug bioavailability

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

drug blood level

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

drug clearance

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

drug cost

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

drug dependence

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

drug derivative

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

drug design

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

drug determination

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

drug distribution

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

drug dose comparison

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

drug effect

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Matrisciano, F. and Storto, M. and Ngomba, Richard T. and Cappuccio, I. and Caricasole, A. and Scaccianoce, S. and Riozzi, B. and Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

Moyanova, S.G. and Kortenska, L.V. and Mitreva, R.G. and Pashova, V.D. and Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

Storto, Marianna and Ngomba, Richard T. and Battaglia, Giuseppe and Freitas, Isabel and Griffini, Patrizia and Richelmi, Plinio and Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

drug effects

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

drug efficacy

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

drug half life

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

drug mechanism

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

drug metabolite

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

drug potentiation

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

drug receptor binding

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

drug research

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

drug safety

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

drug targeting

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

drug tolerability

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

drug-resistance

Biswas, Subhajit and Sukla, Soumi and Field, Hugh J. (2014) Helicase-primase inhibitors for herpes simplex virus: looking to the future of non-nucleoside inhibitors for treating herpes virus infections. Future Medicinal Chemistry, 6 (1). pp. 45-55. ISSN 1756-8919

dyskinesia

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

educational intervention

Siriwardena, A. Niroshan and Middlemass, Jo B. and Ward, Kate and Wilkinson, Carol (2009) Drivers for change in primary care of diabetes following a protected learning time educational event: interview study of practitioners. BMC Medical Education, 8 (4). pp. 1-9. ISSN 1472-6920

efaroxan

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

electrocorticography

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

electroencephalogram

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

electroencephalography

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

Moyanova, S.G. and Kortenska, L.V. and Mitreva, R.G. and Pashova, V.D. and Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

electromyography

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

electron microscopy

Ngomba, Richard T. and Ferraguti, F. and Badura, A. and Citraro, R. and Santolini, I. and Battaglia, G. and Bruno, V. and De Sarro, G. and Simonyi, A. and van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

endothelin 1

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Moyanova, S.G. and Kortenska, L.V. and Mitreva, R.G. and Pashova, V.D. and Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

endothelin 1, age

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

endothelium cell

Granata, Filippo and Potenza, Rossella Luisa and Fiori, Anna and Strom, Roberto and Caronti, Brunella and Molinari, Paola and Donsante, Sonia and Citro, Gennaro and Iacovelli, Luisa and De Blasi, Antonio and Ngomba, Richard T. and Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

Newton, Robert and Holden, Neil S. (2007) Separating transrepression and transactivation: a distressing divorce for the glucocorticoid receptor? Molecular pharmacology, 72 (4). pp. 799-809. ISSN 0026-895X

enzyme

Gruber, T. (2010) From enzyme mimics to sensor molecules. In: ., June 2010, Hungarian Academy of Science, Budapest (Hungary.

enzyme activation

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Granata, Filippo and Potenza, Rossella Luisa and Fiori, Anna and Strom, Roberto and Caronti, Brunella and Molinari, Paola and Donsante, Sonia and Citro, Gennaro and Iacovelli, Luisa and De Blasi, Antonio and Ngomba, Richard T. and Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

enzyme activity

Storto, Marianna and Ngomba, Richard T. and Battaglia, Giuseppe and Freitas, Isabel and Griffini, Patrizia and Richelmi, Plinio and Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

epithelial cells

Kelly, M. M. and King, E. M. and Rider, C. F. and Gwozd, C. and Holden, Neil S. and Eddleston, J. and Zuraw, B. and Leigh, R. and O'Byrne, P. M. and Newton, R. (2012) Corticosteroid-induced gene expression in allergen-challenged asthmatic subjects taking inhaled budesonide. British Journal of Pharmacology, 165 (6). pp. 1737-1747. ISSN 0007-1188

erythromycin

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

ex vivo study

Granata, Filippo and Potenza, Rossella Luisa and Fiori, Anna and Strom, Roberto and Caronti, Brunella and Molinari, Paola and Donsante, Sonia and Citro, Gennaro and Iacovelli, Luisa and De Blasi, Antonio and Ngomba, Richard T. and Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

excitatory amino acid transporter

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

excitatory amino acid transporter 1

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

female

Cinque, C. and Zuena, A .R. and Casolini, P. and Ngomba, Richard T. and Melchiorri, D. and Maccari, S. and Nicoletti, F. and Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

flow

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

fluconazole

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

food and drug administration

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

forelimb

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

forskolin

Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Matrisciano, F. and Storto, M. and Ngomba, Richard T. and Cappuccio, I. and Caricasole, A. and Scaccianoce, S. and Riozzi, B. and Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

fragile X syndrome

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

frontal cortex

Simonyi, Agnes and Ngomba, Richard T. and Storto, Marianna and Catania, Maria V. and Miller, Laura A. and Youngs, Brian and DiGorgi-Gerevini, Valeria and Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

fura 2

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

gamma rhythm

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

gene

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

gene deletion

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

gene expression

Newton, Robert and Holden, Neil S. (2007) Separating transrepression and transactivation: a distressing divorce for the glucocorticoid receptor? Molecular pharmacology, 72 (4). pp. 799-809. ISSN 0026-895X

Nicoletti, F. and Battaglia, G. and Storto, M. and Ngomba, Richard T. and Iacovelli, L. and Arcella, A. and Gradini, R. and Sale, P. and Rampello, L. and De Vita, T. and Di Marco, R. and Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

gene expression regulation

Chivers, Joanna E. and Gong, Wei and King, Elizabeth M. and Seybold, Joachim and Mak, Judith C. and Donnelly, Louise E. and Holden, Neil S. and Newton, Robert (2006) Analysis of the dissociated steroid RU24858 does not exclude a role for inducible genes in the anti-inflammatory actions of glucocorticoids. Molecular pharmacology, 70 (6). pp. 2084-2095. ISSN 0026-895X

King, Elizabeth M. and Kaur, Manminder and Gong, Wei and Rider, Christopher F. and Holden, Neil S. and Newton, Robert (2009) Regulation of tristetraprolin expression by interleukin-1β and dexamethasone in human pulmonary epithelial cells: Roles for nuclear factor-κB and p38 mitogen-activated protein kinase. The journal of pharmacology and experimental therapeutics, 330 (2). pp. 575-585. ISSN 0022-3565

Newton, Robert and Holden, Neil S. and Catley, Matthew C. and Oyelusi, Wale and Leigh, Richard and Proud, David and Barnes, Peter J. (2007) Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IκB kinase inhibitors. The journal of pharmacology and experimental therapeutics, 321 (2). pp. 734-42. ISSN 0022-3565

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

gene inactivation

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

gene transcription

Newton, Robert and Holden, Neil S. (2007) Separating transrepression and transactivation: a distressing divorce for the glucocorticoid receptor? Molecular pharmacology, 72 (4). pp. 799-809. ISSN 0026-895X

general practice

Siriwardena, A. Niroshan and Middlemass, Jo B. and Ward, Kate and Wilkinson, Carol (2009) Drivers for change in primary care of diabetes following a protected learning time educational event: interview study of practitioners. BMC Medical Education, 8 (4). pp. 1-9. ISSN 1472-6920

genetic absence epilepsy

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

genetic disorder

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

genetic model

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

genetics

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

glia cell

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

glioblastoma

Nicoletti, F. and Battaglia, G. and Storto, M. and Ngomba, Richard T. and Iacovelli, L. and Arcella, A. and Gradini, R. and Sale, P. and Rampello, L. and De Vita, T. and Di Marco, R. and Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

glioma

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

glioma cell

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

glucocorticoids

Chivers, Joanna E. and Gong, Wei and King, Elizabeth M. and Seybold, Joachim and Mak, Judith C. and Donnelly, Louise E. and Holden, Neil S. and Newton, Robert (2006) Analysis of the dissociated steroid RU24858 does not exclude a role for inducible genes in the anti-inflammatory actions of glucocorticoids. Molecular pharmacology, 70 (6). pp. 2084-2095. ISSN 0026-895X

Newton, Robert and Holden, Neil S. (2007) Separating transrepression and transactivation: a distressing divorce for the glucocorticoid receptor? Molecular pharmacology, 72 (4). pp. 799-809. ISSN 0026-895X

glutamate receptor 1

Nicoletti, F. and Battaglia, G. and Storto, M. and Ngomba, Richard T. and Iacovelli, L. and Arcella, A. and Gradini, R. and Sale, P. and Rampello, L. and De Vita, T. and Di Marco, R. and Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

glutamate receptor 3

Nicoletti, F. and Battaglia, G. and Storto, M. and Ngomba, Richard T. and Iacovelli, L. and Arcella, A. and Gradini, R. and Sale, P. and Rampello, L. and De Vita, T. and Di Marco, R. and Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

glutamate receptor 4

Nicoletti, F. and Battaglia, G. and Storto, M. and Ngomba, Richard T. and Iacovelli, L. and Arcella, A. and Gradini, R. and Sale, P. and Rampello, L. and De Vita, T. and Di Marco, R. and Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

glutamate receptor antagonist

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

glutamic acid

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

glycine derivative

Matrisciano, F. and Storto, M. and Ngomba, Richard T. and Cappuccio, I. and Caricasole, A. and Scaccianoce, S. and Riozzi, B. and Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

glycoprotein P

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

granule cell

Simonyi, Agnes and Ngomba, Richard T. and Storto, Marianna and Catania, Maria V. and Miller, Laura A. and Youngs, Brian and DiGorgi-Gerevini, Valeria and Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

granulocyte/macrophage colony-stimulating factor (GM-CSF)

Catley, Matthew C. and Chivers, Joanna E. and Holden, Neil S. and Barnes, Peter J. and Newton, Robert (2005) Validation of IKK beta as therapeutic target in airway inflammatory disease by adenoviral-mediated delivery of dominant-negative IKK beta to pulmonary epithelial cells. British journal of pharmacology, 145 (1). pp. 114-22. ISSN 0007-1188

half life time

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

happy puppet syndrome

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

hexaminolevulinate c 14

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

high performance liquid chromatography

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

hippocampus

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Cinque, C. and Zuena, A .R. and Casolini, P. and Ngomba, Richard T. and Melchiorri, D. and Maccari, S. and Nicoletti, F. and Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Manahan-Vaughan, D. and Ngomba, Richard T. and Storto, M. and Kulla, A. and Catania, M. V. and Chiechio, S. and Rampello, L. and Passarelli, F. and Capece, A. and Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Matrisciano, F. and Storto, M. and Ngomba, Richard T. and Cappuccio, I. and Caricasole, A. and Scaccianoce, S. and Riozzi, B. and Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, Richard T. and Ferraguti, F. and Badura, A. and Citraro, R. and Santolini, I. and Battaglia, G. and Bruno, V. and De Sarro, G. and Simonyi, A. and van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Simonyi, Agnes and Ngomba, Richard T. and Storto, Marianna and Catania, Maria V. and Miller, Laura A. and Youngs, Brian and DiGorgi-Gerevini, Valeria and Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

human

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Granata, Filippo and Potenza, Rossella Luisa and Fiori, Anna and Strom, Roberto and Caronti, Brunella and Molinari, Paola and Donsante, Sonia and Citro, Gennaro and Iacovelli, Luisa and De Blasi, Antonio and Ngomba, Richard T. and Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Nicoletti, F. and Battaglia, G. and Storto, M. and Ngomba, Richard T. and Iacovelli, L. and Arcella, A. and Gradini, R. and Sale, P. and Rampello, L. and De Vita, T. and Di Marco, R. and Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

human cell

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Granata, Filippo and Potenza, Rossella Luisa and Fiori, Anna and Strom, Roberto and Caronti, Brunella and Molinari, Paola and Donsante, Sonia and Citro, Gennaro and Iacovelli, Luisa and De Blasi, Antonio and Ngomba, Richard T. and Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

Nicoletti, F. and Battaglia, G. and Storto, M. and Ngomba, Richard T. and Iacovelli, L. and Arcella, A. and Gradini, R. and Sale, P. and Rampello, L. and De Vita, T. and Di Marco, R. and Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

human experiment

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

hydrolysis

Matrisciano, F. and Storto, M. and Ngomba, Richard T. and Cappuccio, I. and Caricasole, A. and Scaccianoce, S. and Riozzi, B. and Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

hypothesis

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

idazoxan

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

imidazoline derivative

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

imidazoline receptor

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

imipramine

Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Matrisciano, F. and Storto, M. and Ngomba, Richard T. and Cappuccio, I. and Caricasole, A. and Scaccianoce, S. and Riozzi, B. and Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

immune response

Granata, Filippo and Potenza, Rossella Luisa and Fiori, Anna and Strom, Roberto and Caronti, Brunella and Molinari, Paola and Donsante, Sonia and Citro, Gennaro and Iacovelli, Luisa and De Blasi, Antonio and Ngomba, Richard T. and Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

immunoblotting

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard T. and Ferraguti, F. and Badura, A. and Citraro, R. and Santolini, I. and Battaglia, G. and Bruno, V. and De Sarro, G. and Simonyi, A. and van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

immunocytochemistry

Simonyi, Agnes and Ngomba, Richard T. and Storto, Marianna and Catania, Maria V. and Miller, Laura A. and Youngs, Brian and DiGorgi-Gerevini, Valeria and Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

immunohistochemistry

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard T. and Ferraguti, F. and Badura, A. and Citraro, R. and Santolini, I. and Battaglia, G. and Bruno, V. and De Sarro, G. and Simonyi, A. and van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

immunoreactivity

Ngomba, Richard T. and Ferraguti, F. and Badura, A. and Citraro, R. and Santolini, I. and Battaglia, G. and Bruno, V. and De Sarro, G. and Simonyi, A. and van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

in situ hybridization

Manahan-Vaughan, D. and Ngomba, Richard T. and Storto, M. and Kulla, A. and Catania, M. V. and Chiechio, S. and Rampello, L. and Passarelli, F. and Capece, A. and Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard T. and Ferraguti, F. and Badura, A. and Citraro, R. and Santolini, I. and Battaglia, G. and Bruno, V. and De Sarro, G. and Simonyi, A. and van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Simonyi, Agnes and Ngomba, Richard T. and Storto, Marianna and Catania, Maria V. and Miller, Laura A. and Youngs, Brian and DiGorgi-Gerevini, Valeria and Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

in vitro study

Granata, Filippo and Potenza, Rossella Luisa and Fiori, Anna and Strom, Roberto and Caronti, Brunella and Molinari, Paola and Donsante, Sonia and Citro, Gennaro and Iacovelli, Luisa and De Blasi, Antonio and Ngomba, Richard T. and Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

in vivo study

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

inflammation

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

inhibition kinetics

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

injection

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

insulin

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

insulin release

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

interleukin 1beta

King, Elizabeth M. and Kaur, Manminder and Gong, Wei and Rider, Christopher F. and Holden, Neil S. and Newton, Robert (2009) Regulation of tristetraprolin expression by interleukin-1β and dexamethasone in human pulmonary epithelial cells: Roles for nuclear factor-κB and p38 mitogen-activated protein kinase. The journal of pharmacology and experimental therapeutics, 330 (2). pp. 575-585. ISSN 0022-3565

Newton, Robert and Holden, Neil S. and Catley, Matthew C. and Oyelusi, Wale and Leigh, Richard and Proud, David and Barnes, Peter J. (2007) Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IκB kinase inhibitors. The journal of pharmacology and experimental therapeutics, 321 (2). pp. 734-42. ISSN 0022-3565

interleukin 6

Newton, Robert and Holden, Neil S. and Catley, Matthew C. and Oyelusi, Wale and Leigh, Richard and Proud, David and Barnes, Peter J. (2007) Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IκB kinase inhibitors. The journal of pharmacology and experimental therapeutics, 321 (2). pp. 734-42. ISSN 0022-3565

interleukin 8

Newton, Robert and Holden, Neil S. and Catley, Matthew C. and Oyelusi, Wale and Leigh, Richard and Proud, David and Barnes, Peter J. (2007) Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IκB kinase inhibitors. The journal of pharmacology and experimental therapeutics, 321 (2). pp. 734-42. ISSN 0022-3565

interviews

Siriwardena, A. Niroshan and Middlemass, Jo B. and Ward, Kate and Wilkinson, Carol (2009) Drivers for change in primary care of diabetes following a protected learning time educational event: interview study of practitioners. BMC Medical Education, 8 (4). pp. 1-9. ISSN 1472-6920

intestine contraction

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

intestine perfusion

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

intravesical drug administration

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

ketamine

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

knockout mouse

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

kynurenine

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

lactation

Cinque, C. and Zuena, A .R. and Casolini, P. and Ngomba, Richard T. and Melchiorri, D. and Maccari, S. and Nicoletti, F. and Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

large intestine

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

latent period

Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

learning

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

learning disorder

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

leukocyte

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

levacecarnine

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

ligand

Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

lipopolysaccharide

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

liquid chromatography

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

liver cell

Storto, Marianna and Ngomba, Richard T. and Battaglia, Giuseppe and Freitas, Isabel and Griffini, Patrizia and Richelmi, Plinio and Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

liver injury

Storto, Marianna and Ngomba, Richard T. and Battaglia, Giuseppe and Freitas, Isabel and Griffini, Patrizia and Richelmi, Plinio and Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

liver necrosis

Storto, Marianna and Ngomba, Richard T. and Battaglia, Giuseppe and Freitas, Isabel and Griffini, Patrizia and Richelmi, Plinio and Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

liver toxicity

Storto, Marianna and Ngomba, Richard T. and Battaglia, Giuseppe and Freitas, Isabel and Griffini, Patrizia and Richelmi, Plinio and Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

long term depression

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

long term potentiation

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Manahan-Vaughan, D. and Ngomba, Richard T. and Storto, M. and Kulla, A. and Catania, M. V. and Chiechio, S. and Rampello, L. and Passarelli, F. and Capece, A. and Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

mGlu5 receptor

D'Amore, V. and Santolini, I. and van Rijn, C.M. and Biagioni, F. and Molinaro, G. and Prete, A. and Conn, P.J. and Lindsley, C.W. and Zhou, Y. and Vinson, P.N. and Rodriguez, A.L. and Jones, C.K and Stauffer, S.R. and Nicoletti, F. and van Luijtelaar, G. and Ngomba, R.T. (2013) Potentiation of mGlu5 receptors with the novel enhancer, VU0360172, reduces spontaneous absence seizures in WAG/Rij rats. Neuropharmacology, 66 . pp. 330-338. ISSN 0028-3908

major depression

Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

male

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Cinque, C. and Zuena, A .R. and Casolini, P. and Ngomba, Richard T. and Melchiorri, D. and Maccari, S. and Nicoletti, F. and Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Granata, Filippo and Potenza, Rossella Luisa and Fiori, Anna and Strom, Roberto and Caronti, Brunella and Molinari, Paola and Donsante, Sonia and Citro, Gennaro and Iacovelli, Luisa and De Blasi, Antonio and Ngomba, Richard T. and Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Manahan-Vaughan, D. and Ngomba, Richard T. and Storto, M. and Kulla, A. and Catania, M. V. and Chiechio, S. and Rampello, L. and Passarelli, F. and Capece, A. and Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Matrisciano, F. and Storto, M. and Ngomba, Richard T. and Cappuccio, I. and Caricasole, A. and Scaccianoce, S. and Riozzi, B. and Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard T. and Ferraguti, F. and Badura, A. and Citraro, R. and Santolini, I. and Battaglia, G. and Bruno, V. and De Sarro, G. and Simonyi, A. and van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Simonyi, Agnes and Ngomba, Richard T. and Storto, Marianna and Catania, Maria V. and Miller, Laura A. and Youngs, Brian and DiGorgi-Gerevini, Valeria and Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

Storto, Marianna and Ngomba, Richard T. and Battaglia, Giuseppe and Freitas, Isabel and Griffini, Patrizia and Richelmi, Plinio and Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

mass spectrometry

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

mavoglurant

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

maze test

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

medical literature

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

medical research

Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

melanoma

Nicoletti, F. and Battaglia, G. and Storto, M. and Ngomba, Richard T. and Iacovelli, L. and Arcella, A. and Gradini, R. and Sale, P. and Rampello, L. and De Vita, T. and Di Marco, R. and Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

memory

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

memory disorder

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

messenger RNA

Cinque, C. and Zuena, A .R. and Casolini, P. and Ngomba, Richard T. and Melchiorri, D. and Maccari, S. and Nicoletti, F. and Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Granata, Filippo and Potenza, Rossella Luisa and Fiori, Anna and Strom, Roberto and Caronti, Brunella and Molinari, Paola and Donsante, Sonia and Citro, Gennaro and Iacovelli, Luisa and De Blasi, Antonio and Ngomba, Richard T. and Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

Manahan-Vaughan, D. and Ngomba, Richard T. and Storto, M. and Kulla, A. and Catania, M. V. and Chiechio, S. and Rampello, L. and Passarelli, F. and Capece, A. and Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Matrisciano, F. and Storto, M. and Ngomba, Richard T. and Cappuccio, I. and Caricasole, A. and Scaccianoce, S. and Riozzi, B. and Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Simonyi, Agnes and Ngomba, Richard T. and Storto, Marianna and Catania, Maria V. and Miller, Laura A. and Youngs, Brian and DiGorgi-Gerevini, Valeria and Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

metabolism

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

metabolite

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

metabotropic receptor

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Cinque, C. and Zuena, A .R. and Casolini, P. and Ngomba, Richard T. and Melchiorri, D. and Maccari, S. and Nicoletti, F. and Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Manahan-Vaughan, D. and Ngomba, Richard T. and Storto, M. and Kulla, A. and Catania, M. V. and Chiechio, S. and Rampello, L. and Passarelli, F. and Capece, A. and Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Matrisciano, F. and Storto, M. and Ngomba, Richard T. and Cappuccio, I. and Caricasole, A. and Scaccianoce, S. and Riozzi, B. and Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

Nicoletti, F. and Battaglia, G. and Storto, M. and Ngomba, Richard T. and Iacovelli, L. and Arcella, A. and Gradini, R. and Sale, P. and Rampello, L. and De Vita, T. and Di Marco, R. and Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Storto, Marianna and Ngomba, Richard T. and Battaglia, Giuseppe and Freitas, Isabel and Griffini, Patrizia and Richelmi, Plinio and Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

metabotropic receptor 1

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Simonyi, Agnes and Ngomba, Richard T. and Storto, Marianna and Catania, Maria V. and Miller, Laura A. and Youngs, Brian and DiGorgi-Gerevini, Valeria and Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

metabotropic receptor 1alpha

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

metabotropic receptor 2

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Manahan-Vaughan, D. and Ngomba, Richard T. and Storto, M. and Kulla, A. and Catania, M. V. and Chiechio, S. and Rampello, L. and Passarelli, F. and Capece, A. and Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Simonyi, Agnes and Ngomba, Richard T. and Storto, Marianna and Catania, Maria V. and Miller, Laura A. and Youngs, Brian and DiGorgi-Gerevini, Valeria and Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

metabotropic receptor 3

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Manahan-Vaughan, D. and Ngomba, Richard T. and Storto, M. and Kulla, A. and Catania, M. V. and Chiechio, S. and Rampello, L. and Passarelli, F. and Capece, A. and Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

metabotropic receptor 3, adaptation

Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

metabotropic receptor 4

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Ngomba, Richard T. and Ferraguti, F. and Badura, A. and Citraro, R. and Santolini, I. and Battaglia, G. and Bruno, V. and De Sarro, G. and Simonyi, A. and van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

metabotropic receptor 5

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Manahan-Vaughan, D. and Ngomba, Richard T. and Storto, M. and Kulla, A. and Catania, M. V. and Chiechio, S. and Rampello, L. and Passarelli, F. and Capece, A. and Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

metabotropic receptor 5, aged

Simonyi, Agnes and Ngomba, Richard T. and Storto, Marianna and Catania, Maria V. and Miller, Laura A. and Youngs, Brian and DiGorgi-Gerevini, Valeria and Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

metabotropic receptor 7

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

metabotropic receptor 8

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

metabotropic receptor 8, absence

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

metabotropic receptor agonist

Cinque, C. and Zuena, A .R. and Casolini, P. and Ngomba, Richard T. and Melchiorri, D. and Maccari, S. and Nicoletti, F. and Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

metabotropic receptor antagonist

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Cinque, C. and Zuena, A .R. and Casolini, P. and Ngomba, Richard T. and Melchiorri, D. and Maccari, S. and Nicoletti, F. and Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Storto, Marianna and Ngomba, Richard T. and Battaglia, Giuseppe and Freitas, Isabel and Griffini, Patrizia and Richelmi, Plinio and Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

metabotropic receptor, absence

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

methodology

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

microdosing

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

microfluorometry

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

microvasculature

Granata, Filippo and Potenza, Rossella Luisa and Fiori, Anna and Strom, Roberto and Caronti, Brunella and Molinari, Paola and Donsante, Sonia and Citro, Gennaro and Iacovelli, Luisa and De Blasi, Antonio and Ngomba, Richard T. and Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

midazolam

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

middle aged, Administration, Intravesical

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

middle cerebral artery

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

middle cerebral artery occlusion

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

mitochondria

Kuroda, Satoshi and Katsura, Ken-ichiro and Hillered, Lars and Bates, Timothy E. and Siesjö, Bo K. (1996) Delayed treatment with alpha-phenyl-N-tert-butyl nitrone (PBN) attenuates secondary mitochondrial dysfunction after transient focal cerebral ischemia in the rat. Neurobiology of Disease, 3 (2). pp. 149-157. ISSN 0969-9961

mitogen activated protein kinase

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Granata, Filippo and Potenza, Rossella Luisa and Fiori, Anna and Strom, Roberto and Caronti, Brunella and Molinari, Paola and Donsante, Sonia and Citro, Gennaro and Iacovelli, Luisa and De Blasi, Antonio and Ngomba, Richard T. and Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

molecular model

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

molecular pathology

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

molecularly targeted therapy

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

morpholine derivative

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

mouse

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Ngomba, Richard T. and Ferraguti, F. and Badura, A. and Citraro, R. and Santolini, I. and Battaglia, G. and Bruno, V. and De Sarro, G. and Simonyi, A. and van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

movement (physiology)

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

multiple sclerosis

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

mutagenesis

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

mutant

Biswas, Subhajit and Sukla, Soumi and Field, Hugh J. (2014) Helicase-primase inhibitors for herpes simplex virus: looking to the future of non-nucleoside inhibitors for treating herpes virus infections. Future Medicinal Chemistry, 6 (1). pp. 45-55. ISSN 1756-8919

n methyl dextro aspartic acid receptor

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

n methyl dextro aspartic acid receptor stimulating agent

Manahan-Vaughan, D. and Ngomba, Richard T. and Storto, M. and Kulla, A. and Catania, M. V. and Chiechio, S. and Rampello, L. and Passarelli, F. and Capece, A. and Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

n phenyl 7 (hydroxyimino)cyclopropabchromen 1a caboxamide

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

n phenyl 7 (hydroxyimino)cyclopropabchromen1a carboxamide

Ngomba, Richard T. and Ferraguti, F. and Badura, A. and Citraro, R. and Santolini, I. and Battaglia, G. and Bruno, V. and De Sarro, G. and Simonyi, A. and van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

naphthalene derivative

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

nerve cell

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

nerve cell network

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

nerve cell plasticity

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Manahan-Vaughan, D. and Ngomba, Richard T. and Storto, M. and Kulla, A. and Catania, M. V. and Chiechio, S. and Rampello, L. and Passarelli, F. and Capece, A. and Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

nervous system electrophysiology

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

neural stem cell

Nicoletti, F. and Battaglia, G. and Storto, M. and Ngomba, Richard T. and Iacovelli, L. and Arcella, A. and Gradini, R. and Sale, P. and Rampello, L. and De Vita, T. and Di Marco, R. and Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

neuroleptic agent

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

neurologic disease

Moyanova, S.G. and Kortenska, L.V. and Mitreva, R.G. and Pashova, V.D. and Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

neuromodulation

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

neuroprotection

Moyanova, S.G. and Kortenska, L.V. and Mitreva, R.G. and Pashova, V.D. and Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

neurotransmission

Nicoletti, F. and Battaglia, G. and Storto, M. and Ngomba, Richard T. and Iacovelli, L. and Arcella, A. and Gradini, R. and Sale, P. and Rampello, L. and De Vita, T. and Di Marco, R. and Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

neurotransmitter release

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

newborn

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

nociceptin

Granata, Filippo and Potenza, Rossella Luisa and Fiori, Anna and Strom, Roberto and Caronti, Brunella and Molinari, Paola and Donsante, Sonia and Citro, Gennaro and Iacovelli, Luisa and De Blasi, Antonio and Ngomba, Richard T. and Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

nonhuman

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Cinque, C. and Zuena, A .R. and Casolini, P. and Ngomba, Richard T. and Melchiorri, D. and Maccari, S. and Nicoletti, F. and Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Granata, Filippo and Potenza, Rossella Luisa and Fiori, Anna and Strom, Roberto and Caronti, Brunella and Molinari, Paola and Donsante, Sonia and Citro, Gennaro and Iacovelli, Luisa and De Blasi, Antonio and Ngomba, Richard T. and Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Manahan-Vaughan, D. and Ngomba, Richard T. and Storto, M. and Kulla, A. and Catania, M. V. and Chiechio, S. and Rampello, L. and Passarelli, F. and Capece, A. and Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Matrisciano, F. and Storto, M. and Ngomba, Richard T. and Cappuccio, I. and Caricasole, A. and Scaccianoce, S. and Riozzi, B. and Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

Moyanova, S.G. and Kortenska, L.V. and Mitreva, R.G. and Pashova, V.D. and Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard T. and Ferraguti, F. and Badura, A. and Citraro, R. and Santolini, I. and Battaglia, G. and Bruno, V. and De Sarro, G. and Simonyi, A. and van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

Simonyi, Agnes and Ngomba, Richard T. and Storto, Marianna and Catania, Maria V. and Miller, Laura A. and Youngs, Brian and DiGorgi-Gerevini, Valeria and Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

Storto, Marianna and Ngomba, Richard T. and Battaglia, Giuseppe and Freitas, Isabel and Griffini, Patrizia and Richelmi, Plinio and Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

normal human

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

nuclear magnetic resonance imaging

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

nucleotide sequence

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

nucleus accumbens

Matrisciano, F. and Storto, M. and Ngomba, Richard T. and Cappuccio, I. and Caricasole, A. and Scaccianoce, S. and Riozzi, B. and Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

nude mouse

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

opiate receptor

Granata, Filippo and Potenza, Rossella Luisa and Fiori, Anna and Strom, Roberto and Caronti, Brunella and Molinari, Paola and Donsante, Sonia and Citro, Gennaro and Iacovelli, Luisa and De Blasi, Antonio and Ngomba, Richard T. and Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

opioid like receptor 1

Granata, Filippo and Potenza, Rossella Luisa and Fiori, Anna and Strom, Roberto and Caronti, Brunella and Molinari, Paola and Donsante, Sonia and Citro, Gennaro and Iacovelli, Luisa and De Blasi, Antonio and Ngomba, Richard T. and Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

oscillation

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

osmotic minipump

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

oxidative stress

Storto, Marianna and Ngomba, Richard T. and Battaglia, Giuseppe and Freitas, Isabel and Griffini, Patrizia and Richelmi, Plinio and Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

p38 Mitogen-Activated Protein Kinases

King, Elizabeth M. and Kaur, Manminder and Gong, Wei and Rider, Christopher F. and Holden, Neil S. and Newton, Robert (2009) Regulation of tristetraprolin expression by interleukin-1β and dexamethasone in human pulmonary epithelial cells: Roles for nuclear factor-κB and p38 mitogen-activated protein kinase. The journal of pharmacology and experimental therapeutics, 330 (2). pp. 575-585. ISSN 0022-3565

pancreas islet

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

paracetamol

Storto, Marianna and Ngomba, Richard T. and Battaglia, Giuseppe and Freitas, Isabel and Griffini, Patrizia and Richelmi, Plinio and Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

parvalbumin

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

passive avoidance

Cinque, C. and Zuena, A .R. and Casolini, P. and Ngomba, Richard T. and Melchiorri, D. and Maccari, S. and Nicoletti, F. and Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

pathogenesis

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

pathology

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

pathophysiology

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Nicoletti, F. and Battaglia, G. and Storto, M. and Ngomba, Richard T. and Iacovelli, L. and Arcella, A. and Gradini, R. and Sale, P. and Rampello, L. and De Vita, T. and Di Marco, R. and Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

patient participation

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

pentetrazole

Ngomba, Richard T. and Ferraguti, F. and Badura, A. and Citraro, R. and Santolini, I. and Battaglia, G. and Bruno, V. and De Sarro, G. and Simonyi, A. and van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

pentobarbital

Manahan-Vaughan, D. and Ngomba, Richard T. and Storto, M. and Kulla, A. and Catania, M. V. and Chiechio, S. and Rampello, L. and Passarelli, F. and Capece, A. and Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

perforant nerve tract

Manahan-Vaughan, D. and Ngomba, Richard T. and Storto, M. and Kulla, A. and Catania, M. V. and Chiechio, S. and Rampello, L. and Passarelli, F. and Capece, A. and Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

perinatal period

Cinque, C. and Zuena, A .R. and Casolini, P. and Ngomba, Richard T. and Melchiorri, D. and Maccari, S. and Nicoletti, F. and Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

pertussis toxin

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

phase 2 clinical trial (topic)

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

phentolamine

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

phentolamine mesylate, animal tissue

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

phosphatidylinositol 3 kinase

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

phosphoserine

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

photosensitizing agent, absence of side effects

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

physiology

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

piperidine derivative

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

polyphosphoinositide

Matrisciano, F. and Storto, M. and Ngomba, Richard T. and Cappuccio, I. and Caricasole, A. and Scaccianoce, S. and Riozzi, B. and Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

polyphosphoinositide, absence

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

polyphosphoinositide, animal experiment

Cinque, C. and Zuena, A .R. and Casolini, P. and Ngomba, Richard T. and Melchiorri, D. and Maccari, S. and Nicoletti, F. and Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

pomaglumetad methionil

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

practice guideline

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

prenatal stress

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

primary care

Siriwardena, A. Niroshan and Middlemass, Jo B. and Ward, Kate and Wilkinson, Carol (2009) Drivers for change in primary care of diabetes following a protected learning time educational event: interview study of practitioners. BMC Medical Education, 8 (4). pp. 1-9. ISSN 1472-6920

priority journal

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Cinque, C. and Zuena, A .R. and Casolini, P. and Ngomba, Richard T. and Melchiorri, D. and Maccari, S. and Nicoletti, F. and Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Granata, Filippo and Potenza, Rossella Luisa and Fiori, Anna and Strom, Roberto and Caronti, Brunella and Molinari, Paola and Donsante, Sonia and Citro, Gennaro and Iacovelli, Luisa and De Blasi, Antonio and Ngomba, Richard T. and Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Manahan-Vaughan, D. and Ngomba, Richard T. and Storto, M. and Kulla, A. and Catania, M. V. and Chiechio, S. and Rampello, L. and Passarelli, F. and Capece, A. and Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Matrisciano, F. and Storto, M. and Ngomba, Richard T. and Cappuccio, I. and Caricasole, A. and Scaccianoce, S. and Riozzi, B. and Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

Moyanova, S.G. and Kortenska, L.V. and Mitreva, R.G. and Pashova, V.D. and Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard T. and Ferraguti, F. and Badura, A. and Citraro, R. and Santolini, I. and Battaglia, G. and Bruno, V. and De Sarro, G. and Simonyi, A. and van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Nicoletti, F. and Battaglia, G. and Storto, M. and Ngomba, Richard T. and Iacovelli, L. and Arcella, A. and Gradini, R. and Sale, P. and Rampello, L. and De Vita, T. and Di Marco, R. and Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Simonyi, Agnes and Ngomba, Richard T. and Storto, Marianna and Catania, Maria V. and Miller, Laura A. and Youngs, Brian and DiGorgi-Gerevini, Valeria and Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

Storto, Marianna and Ngomba, Richard T. and Battaglia, Giuseppe and Freitas, Isabel and Griffini, Patrizia and Richelmi, Plinio and Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

priority journal, Administration, Oral

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

priority journal, Adrenergic alpha-Antagonists

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

pritelivir

Biswas, Subhajit and Sukla, Soumi and Field, Hugh J. (2014) Helicase-primase inhibitors for herpes simplex virus: looking to the future of non-nucleoside inhibitors for treating herpes virus infections. Future Medicinal Chemistry, 6 (1). pp. 45-55. ISSN 1756-8919

prostaglandin GH synthase

Catley, Matthew C. and Chivers, Joanna E. and Holden, Neil S. and Barnes, Peter J. and Newton, Robert (2005) Validation of IKK beta as therapeutic target in airway inflammatory disease by adenoviral-mediated delivery of dominant-negative IKK beta to pulmonary epithelial cells. British journal of pharmacology, 145 (1). pp. 114-22. ISSN 0007-1188

protected learning time

Siriwardena, A. Niroshan and Middlemass, Jo B. and Ward, Kate and Wilkinson, Carol (2009) Drivers for change in primary care of diabetes following a protected learning time educational event: interview study of practitioners. BMC Medical Education, 8 (4). pp. 1-9. ISSN 1472-6920

protein Homer 1a

Matrisciano, F. and Storto, M. and Ngomba, Richard T. and Cappuccio, I. and Caricasole, A. and Scaccianoce, S. and Riozzi, B. and Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

protein analysis

Matrisciano, F. and Storto, M. and Ngomba, Richard T. and Cappuccio, I. and Caricasole, A. and Scaccianoce, S. and Riozzi, B. and Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

protein expression

Arcella, A. and Carpinelli, G. and Battaglia, G. and D'Onofrio, M. and Santoro, F. and Ngomba, R. T. and Bruno, V. and Casolini, P. and Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Cinque, C. and Zuena, A .R. and Casolini, P. and Ngomba, Richard T. and Melchiorri, D. and Maccari, S. and Nicoletti, F. and Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Granata, Filippo and Potenza, Rossella Luisa and Fiori, Anna and Strom, Roberto and Caronti, Brunella and Molinari, Paola and Donsante, Sonia and Citro, Gennaro and Iacovelli, Luisa and De Blasi, Antonio and Ngomba, Richard T. and Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

Manahan-Vaughan, D. and Ngomba, Richard T. and Storto, M. and Kulla, A. and Catania, M. V. and Chiechio, S. and Rampello, L. and Passarelli, F. and Capece, A. and Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Matrisciano, F. and Storto, M. and Ngomba, Richard T. and Cappuccio, I. and Caricasole, A. and Scaccianoce, S. and Riozzi, B. and Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard T. and Ferraguti, F. and Badura, A. and Citraro, R. and Santolini, I. and Battaglia, G. and Bruno, V. and De Sarro, G. and Simonyi, A. and van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Simonyi, Agnes and Ngomba, Richard T. and Storto, Marianna and Catania, Maria V. and Miller, Laura A. and Youngs, Brian and DiGorgi-Gerevini, Valeria and Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

protein function

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Ngomba, R. T. and Biagioni, F. and Casciato, S. and Willems-Van Bree, E. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard T. and Ferraguti, F. and Badura, A. and Citraro, R. and Santolini, I. and Battaglia, G. and Bruno, V. and De Sarro, G. and Simonyi, A. and van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

protein hydrolysis

Cinque, C. and Zuena, A .R. and Casolini, P. and Ngomba, Richard T. and Melchiorri, D. and Maccari, S. and Nicoletti, F. and Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

protein interaction

Matrisciano, F. and Scaccianoce, S. and Del Bianco, P. and Panaccione, I. and Canudas, A. M. and Battaglia, G. and Riozzi, B. and Ngomba, R. T. and Molinaro, G. and Tatarelli, R. and Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

protein localization

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard T. and Ferraguti, F. and Badura, A. and Citraro, R. and Santolini, I. and Battaglia, G. and Bruno, V. and De Sarro, G. and Simonyi, A. and van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

protein protein interaction

Granata, Filippo and Potenza, Rossella Luisa and Fiori, Anna and Strom, Roberto and Caronti, Brunella and Molinari, Paola and Donsante, Sonia and Citro, Gennaro and Iacovelli, Luisa and De Blasi, Antonio and Ngomba, Richard T. and Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

protein synthesis

Granata, Filippo and Potenza, Rossella Luisa and Fiori, Anna and Strom, Roberto and Caronti, Brunella and Molinari, Paola and Donsante, Sonia and Citro, Gennaro and Iacovelli, Luisa and De Blasi, Antonio and Ngomba, Richard T. and Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

protein synthesis inhibition

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

publication

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

putamen

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

pyrazole derivative, animal experiment

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

pyridine derivative, allosterism

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

qualitative research

Siriwardena, A. Niroshan and Middlemass, Jo B. and Ward, Kate and Wilkinson, Carol (2009) Drivers for change in primary care of diabetes following a protected learning time educational event: interview study of practitioners. BMC Medical Education, 8 (4). pp. 1-9. ISSN 1472-6920

rab3A GTP-Binding Protein

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

radiation dose

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

radioactivity

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

radiopharmaceutical agent

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

rat

Besong, Gilbert and Battaglia, Giuseppe and D'Onofrio, Mara and Di Marco, Roberto and Ngomba, Richard T. and Storto, Marianna and Castiglione, Marzia and Mangano, Katia and Busceti, Carla L. and Nicoletti, Ferdinando R. and Bacon, Kevin and Tusche, Michael and Valenti, Ornella and Conn, Peter Jeffrey and Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Bikbaev, A. and Neyman, S. and Ngomba, Richard and Conn, J. and Nicoletti, F. and Manahan-Vaughan, D. (2008)