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(3,4 dihydro 2h pyranol2,3 bquinolin 7yl)(cis 4 ethoxycycloexyl) methanone 1 (2,4 dichlorophenyl) 5 (4 iodophenyl) 4 methyl n (1 piperidyl) 1h pyrazole 3 carboxamide 1,2,3,6 tetrahydro 1 methyl 4 phenylpyridine 2 amino 2 (2 carboxycyclopropyl) 3 (xanthen 9 yl) propionic acid 2 amino 2 (2 carboxycyclopropyl) 3 (xanthen 9 yl)propionic acid 2 amino 3 (3,4 dichlorobenzyloxy) 6 fluorobicyclo3.1.0hexane 2,6 dicarboxylic acid 2 methyl 6 (phenylethynyl)pyridine 2,3 dihydro 5 methyl 3 (morpholinomethyl) 6 (1 naphthoyl)pyrrolo1,2,3 de1,4benzoxazine 3 (3, 4 dichlorobenzylamino) propyl (diethoxymethyl) phosphinic acid 3 (3,4 dichlorobenzylamino)propyl(diethoxymethyl)phosphinic acid 3,5 dihydroxyphenylglycine 4 amino 2 thiabicyclo3.1.0hexane 4,6 dicarboxylic acid 2,2 dioxide 4 aminobutyric acid 5-aminolevulinic acid hexyl ester 6 hydroxydopamine 9h xanthene 9 carboxylic acid(4 trifluoromethyloxazol 2 yl)amide 9h xanthene 9 carboxylix acid (4 trifluoromethyl oxazol 2 yl)amide Absence epilepsy Adolescent Adult Aged Aged, 80 and over Animals Anthraquinones Anti-Inflammatory Agents Anticoagulants Anticonvulsants Apoptosis Arachidonic Acids Area Under Curve Article Asthma August Copenhagen Irish rat BEAS-2B epithelial cells Behavior, Animal Benzofurans Benzoxazines Benzylamines Biological Availability Brain CB receptors Calcium Cannabinoid Receptor Agonists Carbon Radioisotopes Cells, Cultured Central Nervous System Diseases Cerebral Cortex Cerebral Infarction Chemical sympathectomy Chromatography, Liquid Chronic treatment Ciprofloxacin Coloring Agents Corticosteroid Cross-Over Studies Cyclic AMP Cytosol DNA Primers Disease Models, Animal Dose-Response Relationship, Drug Down-Regulation Drug Monitoring Electroencephalography Electrophysiology Endocannabinoids Epilepsy Epilepsy, Absence Epithelial cells Estradiol Evans Blue Excitatory Amino Acid Antagonists Female Forelimb Forskolin GABA Modulators GABA-A Receptor Antagonists GABAergic system GILZ GRM1 gene GRM2 gene Gastrointestinal Motility Genetic Glucocorticoid Glucose Glutamic Acid Half-Life Heterocyclic compounds Hindlimb Histamine Humans I-kappa B Kinase IL-6 IL-8 Imidazoles In Vitro Infarction, Middle Cerebral Artery Inflammation Injections, Intravenous Injections, Intraventricular Intestinal Secretions Intestine, Large Ischemia Ischemic Attack, Transient Islets of Langerhans Kainic Acid Ligands MTEP Male Mepyramine Mice Mice, Inbred C57BL Mice, Knockout Middle Aged Models, Molecular Molecular Targeted Therapy Morpholines Motor Activity Movement Munc18 Proteins Munc18 protein Muscle Contraction NF-?B NF-kappa B NHBE Naphthalenes Nerve Net Neural Pathways Neuroglia Nucleic Acid Synthesis Inhibitors Oxazines PBN Parkinson disease Perfusion Phosphinic Acids Photosensitizing Agents Piperidines Polyunsaturated Alkamides Postural Balance Pregnancy Prenatal Exposure Delayed Effects Psychomotor Performance Pulmonary epithelium Pyrazoles Quinolines R-SNARE Proteins RNA, Messenger RO0711401 Rab protein Rats Rats, Inbred ACI Rats, Inbred Strains Rats, Mutant Strains Rats, Sprague-Dawley Rats, Wistar Receptor, Cannabinoid, CB1 Receptors, Drug Receptors, Metabotropic Glutamate Reflex Reverse Transcriptase Polymerase Chain Reaction Rimonabant Seizure Seizures Signal Transduction Smooth muscle cells Spike-wave discharges Spinocerebellar Ataxias Spinocerebellar Ataxias, Animals Stress, Psychological Supersensitivity Synapsins Synaptic Transmission Thalamic Nuclei Thalamus Tolerance Transactivation Transcription VU0360172 WAG/Rij rats WIN55,212, Animals Western blotting Western blotting, Amino Acids Wistar albino Glaxo rat Xanthenes absence acetylcysteine adenosine triphosphatase (potassium) adolescent adult agmatine algorithm alpha 1 adrenergic receptor blocking agent amantadine amenamevir aminolevulinic acid aminolevulinic acid hexyl ester analysis of variance anandamide animal animal experiment animal model animal tissue anti-inflammatories anti-inflammatory effects antidepressant activity antiestrogen antiviral anxiety area under the curve article atypical antipsychotic agent autism azd 2066 basimglurant behavior benzoxazine derivative beta-agonists beta2-adrenoceptor agonists bioavailability blood body posture brain cortex brain damage brain infarction size brain ischemia brain level brain protection calcium cell level calcium ion calcium transport cannabinoid 1 receptor cannabinoid 1 receptor agonist cannabis addiction carbon carbon 14 caudate nucleus central nervous system disease cerebellum disease cerebrovascular accident cinnabarinic acid clinical trial cocaine dependence conference paper confidence interval controlled clinical trial controlled study convalescence crossover procedure cytochrome P450 3A4 cytokines data analysis depolarization depression dexamethasones dextro aspartic acid diabetes mellitus diazepam diazoxide dipraglurant disease model dose calculation dose response dose time effect relation drug absorption drug administration route drug bioavailability drug blood level drug clearance drug cost drug dependence drug derivative drug design drug determination drug distribution drug dose comparison drug effect drug effects drug efficacy drug half life drug mechanism drug metabolite drug potentiation drug receptor binding drug research drug safety drug targeting drug tolerability drug-resistance dyskinesia educational intervention efaroxan electrocorticography electroencephalogram electroencephalography electromyography endothelin 1 endothelin 1, age endothelium cell epithelial cells erythromycin excitatory amino acid transporter excitatory amino acid transporter 1 female flow fluconazole food and drug administration forelimb fragile X syndrome fura 2 gene gene deletion gene expression gene expression regulation gene inactivation gene transcription general practice genetic absence epilepsy genetic disorder genetic model genetics glia cell glucocorticoids glutamic acid glycoprotein P granulocyte/macrophage colony-stimulating factor (GM-CSF) half life time happy puppet syndrome hexaminolevulinate c 14 high performance liquid chromatography hippocampus human human cell human experiment hydrolysis idazoxan imidazoline derivative imidazoline receptor immunoblotting immunohistochemistry in situ hybridization in vivo study insulin insulin release interleukin 1beta interleukin 6 interleukin 8 interviews intestine contraction intestine perfusion intravesical drug administration ketamine kynurenine large intestine levacecarnine ligand lipopolysaccharide liquid chromatography long term depression mGlu5 receptor male mass spectrometry mavoglurant maze test medical literature messenger RNA metabolism metabolite metabotropic receptor metabotropic receptor 1 metabotropic receptor 1alpha metabotropic receptor 2 metabotropic receptor 3 metabotropic receptor 4 metabotropic receptor 5 metabotropic receptor 7 metabotropic receptor 8 metabotropic receptor 8, absence metabotropic receptor agonist metabotropic receptor antagonist metabotropic receptor, absence methodology microdosing microfluorometry midazolam middle aged, Administration, Intravesical middle cerebral artery middle cerebral artery occlusion mitochondria molecular model molecular pathology molecularly targeted therapy morpholine derivative mouse movement (physiology) mutagenesis mutant n methyl dextro aspartic acid receptor n phenyl 7 (hydroxyimino)cyclopropabchromen 1a caboxamide naphthalene derivative nerve cell nervous system electrophysiology neuroleptic agent neuromodulation neuroprotection neurotransmitter release nonhuman normal human oscillation p38 Mitogen-Activated Protein Kinases pancreas islet parvalbumin pathogenesis pathology pathophysiology patient participation phase 2 clinical trial (topic) phentolamine phentolamine mesylate, animal tissue photosensitizing agent, absence of side effects piperidine derivative polyphosphoinositide, absence pomaglumetad methionil practice guideline prenatal stress primary care priority journal priority journal, Administration, Oral priority journal, Adrenergic alpha-Antagonists pritelivir prostaglandin GH synthase protected learning time protein expression protein function protein localization publication putamen pyrazole derivative, animal experiment qualitative research rab3A GTP-Binding Protein radiation dose radioactivity radiopharmaceutical agent rat rat strain, Analysis of Variance receptor down regulation regulatory mechanism respiratory mucosa review rhein rimonabant, absence ro 0711401 ro 4419513 ro 4432717 schizophrenia seizure sennoside, animal experiment sensitivity analysis sensorimotor function sensorimotor integration serotonin 2A receptor signal transduction somatosensory cortex spike spike wave spike wave discharge statistical analysis stereotactic device strain gauge transducer striate cortex syn 119 synapse vesicle synapsin I synapsin II synaptic transmission synaptobrevin synaptophysin synaptosomal associated protein 25 synaptosome syntaxin 1 tandem mass spectrometry tandem mass spectrometry, Animals thalamocortical tract thalamocortical tract, Animals thalamus thalamus nucleus thalamus reticular nucleus tobacco dependence tolbutamide toxicology transducer, Animal tristetrapolin tubercidin unclassified drug unclassified drug, animal cell unclassified drug, animal experiment ventroposterolateral nucleus, Allosteric Regulation ventroposteromedial thalamic nucleus, Anandamide vesicular glutamate transporter 1, animal experiment volunteer vu 0360172 warfarin wild type, Animals zk 253, adult zk 253, area under the curve
Number of items at this level: 720.

(3,4 dihydro 2h pyranol2,3 bquinolin 7yl)(cis 4 ethoxycycloexyl) methanone

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

1 (2,4 dichlorophenyl) 5 (4 iodophenyl) 4 methyl n (1 piperidyl) 1h pyrazole 3 carboxamide

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

1,2,3,6 tetrahydro 1 methyl 4 phenylpyridine

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

2 amino 2 (2 carboxycyclopropyl) 3 (xanthen 9 yl) propionic acid

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

2 amino 2 (2 carboxycyclopropyl) 3 (xanthen 9 yl)propionic acid

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

2 amino 3 (3,4 dichlorobenzyloxy) 6 fluorobicyclo3.1.0hexane 2,6 dicarboxylic acid

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

2 methyl 6 (phenylethynyl)pyridine

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

2,3 dihydro 5 methyl 3 (morpholinomethyl) 6 (1 naphthoyl)pyrrolo1,2,3 de1,4benzoxazine

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

3 (3, 4 dichlorobenzylamino) propyl (diethoxymethyl) phosphinic acid

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

3 (3,4 dichlorobenzylamino)propyl(diethoxymethyl)phosphinic acid

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

3,5 dihydroxyphenylglycine

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

4 amino 2 thiabicyclo3.1.0hexane 4,6 dicarboxylic acid 2,2 dioxide

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

4 aminobutyric acid

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

5-aminolevulinic acid hexyl ester

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

6 hydroxydopamine

Chess-Williams, RG and Grassby, Paul and Culling, W. and Penny, W. and Broadley, K. J. and Sheridan, D. J. (1985) Cardiac postjunctional supersensitivity to β-agonists after chronic chemical sympathectomy with 6-hydroxydopamine. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 329 (2). pp. 162-166. ISSN 0028-1298

9h xanthene 9 carboxylic acid(4 trifluoromethyloxazol 2 yl)amide

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

9h xanthene 9 carboxylix acid (4 trifluoromethyl oxazol 2 yl)amide

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Absence epilepsy

D'Amore, V. and Santolini, I. and Celli, R. and Lionetto, L. and De Fusco, A. and Simmaco, M. and van Rijn, C. M. and Vieira, E. and Stauffer, S.R. and Conn, P. J. and Bosco, P. and Nicoletti, F. and van Luijtelaar, G. and Ngomba, R. T. (2014) Head-to head comparison of mGlu1 and mGlu5 receptor activation in chronic treatment of absence epilepsy in WAG/Rij rats. Neuropharmacology, 85 . pp. 91-103. ISSN 0028-3908

D'Amore, V. and Santolini, I. and van Rijn, C.M. and Biagioni, F. and Molinaro, G. and Prete, A. and Conn, P.J. and Lindsley, C.W. and Zhou, Y. and Vinson, P.N. and Rodriguez, A.L. and Jones, C.K and Stauffer, S.R. and Nicoletti, F. and van Luijtelaar, G. and Ngomba, R.T. (2013) Potentiation of mGlu5 receptors with the novel enhancer, VU0360172, reduces spontaneous absence seizures in WAG/Rij rats. Neuropharmacology, 66 . pp. 330-338. ISSN 0028-3908

Adolescent

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Adult

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Aged

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Aged, 80 and over

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Animals

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Anthraquinones

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Anti-Inflammatory Agents

Chivers, Joanna E. and Gong, Wei and King, Elizabeth M. and Seybold, Joachim and Mak, Judith C. and Donnelly, Louise E. and Holden, Neil S. and Newton, Robert (2006) Analysis of the dissociated steroid RU24858 does not exclude a role for inducible genes in the anti-inflammatory actions of glucocorticoids. Molecular pharmacology, 70 (6). pp. 2084-2095. ISSN 0026-895X

Anticoagulants

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Anticonvulsants

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Apoptosis

Catley, Matthew C. and Chivers, Joanna E. and Holden, Neil S. and Barnes, Peter J. and Newton, Robert (2005) Validation of IKK beta as therapeutic target in airway inflammatory disease by adenoviral-mediated delivery of dominant-negative IKK beta to pulmonary epithelial cells. British journal of pharmacology, 145 (1). pp. 114-22. ISSN 0007-1188

Arachidonic Acids

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Area Under Curve

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Article

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Asthma

Holden, Neil S. and Rider, C. F. and Bell, M. J. and Velayudhan, J. and King, E. M. and Kaur, M. and Salmon, M. and Giembycz, M. A. and Newton, R. (2010) Enhancement of inflammatory mediator release by beta(2)-adrenoceptor agonists in airway epithelial cells is reversed by glucocorticoid action. British journal of pharmacology, 160 (2). pp. 410-420. ISSN 0007-1188

Kelly, M. M. and King, E. M. and Rider, C. F. and Gwozd, C. and Holden, Neil S. and Eddleston, J. and Zuraw, B. and Leigh, R. and O'Byrne, P. M. and Newton, R. (2012) Corticosteroid-induced gene expression in allergen-challenged asthmatic subjects taking inhaled budesonide. British Journal of Pharmacology, 165 (6). pp. 1737-1747. ISSN 0007-1188

August Copenhagen Irish rat

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

BEAS-2B epithelial cells

Holden, Neil S. and Gong, W. and King, E. M. and Kaur, M. and Giembycz, M. A. and Newton, R. (2007) Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. British journal of pharmacology, 152 (6). pp. 891-902. ISSN 0007-1188

Holden, Neil S. and Rider, C. F. and Bell, M. J. and Velayudhan, J. and King, E. M. and Kaur, M. and Salmon, M. and Giembycz, M. A. and Newton, R. (2010) Enhancement of inflammatory mediator release by beta(2)-adrenoceptor agonists in airway epithelial cells is reversed by glucocorticoid action. British journal of pharmacology, 160 (2). pp. 410-420. ISSN 0007-1188

Behavior, Animal

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Benzofurans

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

Benzoxazines

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Benzylamines

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Biological Availability

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Brain

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

CB receptors

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Calcium

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

Cannabinoid Receptor Agonists

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Carbon Radioisotopes

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Cells, Cultured

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Central Nervous System Diseases

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Cerebral Cortex

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Cerebral Infarction

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Chemical sympathectomy

Chess-Williams, RG and Grassby, Paul and Culling, W. and Penny, W. and Broadley, K. J. and Sheridan, D. J. (1985) Cardiac postjunctional supersensitivity to β-agonists after chronic chemical sympathectomy with 6-hydroxydopamine. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 329 (2). pp. 162-166. ISSN 0028-1298

Chromatography, Liquid

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Chronic treatment

D'Amore, V. and Santolini, I. and Celli, R. and Lionetto, L. and De Fusco, A. and Simmaco, M. and van Rijn, C. M. and Vieira, E. and Stauffer, S.R. and Conn, P. J. and Bosco, P. and Nicoletti, F. and van Luijtelaar, G. and Ngomba, R. T. (2014) Head-to head comparison of mGlu1 and mGlu5 receptor activation in chronic treatment of absence epilepsy in WAG/Rij rats. Neuropharmacology, 85 . pp. 91-103. ISSN 0028-3908

Ciprofloxacin

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Coloring Agents

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Corticosteroid

Kelly, M. M. and King, E. M. and Rider, C. F. and Gwozd, C. and Holden, Neil S. and Eddleston, J. and Zuraw, B. and Leigh, R. and O'Byrne, P. M. and Newton, R. (2012) Corticosteroid-induced gene expression in allergen-challenged asthmatic subjects taking inhaled budesonide. British Journal of Pharmacology, 165 (6). pp. 1737-1747. ISSN 0007-1188

Cross-Over Studies

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Cyclic AMP

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Cytosol

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

DNA Primers

Chivers, Joanna E. and Gong, Wei and King, Elizabeth M. and Seybold, Joachim and Mak, Judith C. and Donnelly, Louise E. and Holden, Neil S. and Newton, Robert (2006) Analysis of the dissociated steroid RU24858 does not exclude a role for inducible genes in the anti-inflammatory actions of glucocorticoids. Molecular pharmacology, 70 (6). pp. 2084-2095. ISSN 0026-895X

Disease Models, Animal

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Dose-Response Relationship, Drug

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Down-Regulation

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

Drug Monitoring

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Electroencephalography

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Electrophysiology

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Endocannabinoids

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Epilepsy

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Epilepsy, Absence

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Epithelial cells

Newton, Robert and Holden, Neil S. and Catley, Matthew C. and Oyelusi, Wale and Leigh, Richard and Proud, David and Barnes, Peter J. (2007) Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IκB kinase inhibitors. The journal of pharmacology and experimental therapeutics, 321 (2). pp. 734-42. ISSN 0022-3565

Rider, Christopher F. and King, Elizabeth M. and Holden, Neil S. and Giembycz, Mark A. and Newton, Robert (2011) Inflammatory stimuli inhibit glucocorticoid-dependent transactivation in human pulmonary epithelial cells: rescue by long-acting beta2-adrenoceptor agonists. Journal of Pharmacology and Experimental Therapeutics, 338 (3). pp. 860-869. ISSN 0022-3565

Estradiol

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Evans Blue

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Excitatory Amino Acid Antagonists

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Female

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Forelimb

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Forskolin

HAWTHORN, M. H. and CHESSWILLIAMS, R. G. and Grassby, P. F. and BROADLEY, K. J. (1985) The use of forskolin to investigate the site of cardiac beta-adrenoreceptor supersensitivity. Journal of Autonomic Pharmacology, 5 (3). pp. 231-239. ISSN 0144-1795

GABA Modulators

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

GABA-A Receptor Antagonists

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

GABAergic system

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

GILZ

Kelly, M. M. and King, E. M. and Rider, C. F. and Gwozd, C. and Holden, Neil S. and Eddleston, J. and Zuraw, B. and Leigh, R. and O'Byrne, P. M. and Newton, R. (2012) Corticosteroid-induced gene expression in allergen-challenged asthmatic subjects taking inhaled budesonide. British Journal of Pharmacology, 165 (6). pp. 1737-1747. ISSN 0007-1188

GRM1 gene

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

GRM2 gene

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Gastrointestinal Motility

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Genetic

Chivers, Joanna E. and Gong, Wei and King, Elizabeth M. and Seybold, Joachim and Mak, Judith C. and Donnelly, Louise E. and Holden, Neil S. and Newton, Robert (2006) Analysis of the dissociated steroid RU24858 does not exclude a role for inducible genes in the anti-inflammatory actions of glucocorticoids. Molecular pharmacology, 70 (6). pp. 2084-2095. ISSN 0026-895X

Glucocorticoid

Holden, Neil S. and Gong, W. and King, E. M. and Kaur, M. and Giembycz, M. A. and Newton, R. (2007) Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. British journal of pharmacology, 152 (6). pp. 891-902. ISSN 0007-1188

Holden, Neil S. and Rider, C. F. and Bell, M. J. and Velayudhan, J. and King, E. M. and Kaur, M. and Salmon, M. and Giembycz, M. A. and Newton, R. (2010) Enhancement of inflammatory mediator release by beta(2)-adrenoceptor agonists in airway epithelial cells is reversed by glucocorticoid action. British journal of pharmacology, 160 (2). pp. 410-420. ISSN 0007-1188

Rider, Christopher F. and King, Elizabeth M. and Holden, Neil S. and Giembycz, Mark A. and Newton, Robert (2011) Inflammatory stimuli inhibit glucocorticoid-dependent transactivation in human pulmonary epithelial cells: rescue by long-acting beta2-adrenoceptor agonists. Journal of Pharmacology and Experimental Therapeutics, 338 (3). pp. 860-869. ISSN 0022-3565

Glucose

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

Glutamic Acid

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Half-Life

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Heterocyclic compounds

Newton, Robert and Holden, Neil S. and Catley, Matthew C. and Oyelusi, Wale and Leigh, Richard and Proud, David and Barnes, Peter J. (2007) Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IκB kinase inhibitors. The journal of pharmacology and experimental therapeutics, 321 (2). pp. 734-42. ISSN 0022-3565

Hindlimb

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Histamine

Holden, Neil S. and Gong, W. and King, E. M. and Kaur, M. and Giembycz, M. A. and Newton, R. (2007) Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. British journal of pharmacology, 152 (6). pp. 891-902. ISSN 0007-1188

Humans

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

I-kappa B Kinase

Catley, Matthew C. and Chivers, Joanna E. and Holden, Neil S. and Barnes, Peter J. and Newton, Robert (2005) Validation of IKK beta as therapeutic target in airway inflammatory disease by adenoviral-mediated delivery of dominant-negative IKK beta to pulmonary epithelial cells. British journal of pharmacology, 145 (1). pp. 114-22. ISSN 0007-1188

Newton, Robert and Holden, Neil S. and Catley, Matthew C. and Oyelusi, Wale and Leigh, Richard and Proud, David and Barnes, Peter J. (2007) Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IκB kinase inhibitors. The journal of pharmacology and experimental therapeutics, 321 (2). pp. 734-42. ISSN 0022-3565

IL-6

Holden, Neil S. and Gong, W. and King, E. M. and Kaur, M. and Giembycz, M. A. and Newton, R. (2007) Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. British journal of pharmacology, 152 (6). pp. 891-902. ISSN 0007-1188

Holden, Neil S. and Rider, C. F. and Bell, M. J. and Velayudhan, J. and King, E. M. and Kaur, M. and Salmon, M. and Giembycz, M. A. and Newton, R. (2010) Enhancement of inflammatory mediator release by beta(2)-adrenoceptor agonists in airway epithelial cells is reversed by glucocorticoid action. British journal of pharmacology, 160 (2). pp. 410-420. ISSN 0007-1188

IL-8

Catley, Matthew C. and Chivers, Joanna E. and Holden, Neil S. and Barnes, Peter J. and Newton, Robert (2005) Validation of IKK beta as therapeutic target in airway inflammatory disease by adenoviral-mediated delivery of dominant-negative IKK beta to pulmonary epithelial cells. British journal of pharmacology, 145 (1). pp. 114-22. ISSN 0007-1188

Holden, Neil S. and Gong, W. and King, E. M. and Kaur, M. and Giembycz, M. A. and Newton, R. (2007) Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. British journal of pharmacology, 152 (6). pp. 891-902. ISSN 0007-1188

Holden, Neil S. and Rider, C. F. and Bell, M. J. and Velayudhan, J. and King, E. M. and Kaur, M. and Salmon, M. and Giembycz, M. A. and Newton, R. (2010) Enhancement of inflammatory mediator release by beta(2)-adrenoceptor agonists in airway epithelial cells is reversed by glucocorticoid action. British journal of pharmacology, 160 (2). pp. 410-420. ISSN 0007-1188

Imidazoles

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

In Vitro

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Infarction, Middle Cerebral Artery

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Inflammation

Holden, Neil S. and Gong, W. and King, E. M. and Kaur, M. and Giembycz, M. A. and Newton, R. (2007) Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. British journal of pharmacology, 152 (6). pp. 891-902. ISSN 0007-1188

Holden, Neil S. and Rider, C. F. and Bell, M. J. and Velayudhan, J. and King, E. M. and Kaur, M. and Salmon, M. and Giembycz, M. A. and Newton, R. (2010) Enhancement of inflammatory mediator release by beta(2)-adrenoceptor agonists in airway epithelial cells is reversed by glucocorticoid action. British journal of pharmacology, 160 (2). pp. 410-420. ISSN 0007-1188

Injections, Intravenous

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Injections, Intraventricular

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Intestinal Secretions

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Intestine, Large

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Ischemia

Kuroda, Satoshi and Katsura, Ken-ichiro and Hillered, Lars and Bates, Timothy E. and Siesjö, Bo K. (1996) Delayed treatment with alpha-phenyl-N-tert-butyl nitrone (PBN) attenuates secondary mitochondrial dysfunction after transient focal cerebral ischemia in the rat. Neurobiology of Disease, 3 (2). pp. 149-157. ISSN 0969-9961

Ischemic Attack, Transient

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Islets of Langerhans

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

Kainic Acid

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Ligands

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

MTEP

D'Amore, V. and Santolini, I. and van Rijn, C.M. and Biagioni, F. and Molinaro, G. and Prete, A. and Conn, P.J. and Lindsley, C.W. and Zhou, Y. and Vinson, P.N. and Rodriguez, A.L. and Jones, C.K and Stauffer, S.R. and Nicoletti, F. and van Luijtelaar, G. and Ngomba, R.T. (2013) Potentiation of mGlu5 receptors with the novel enhancer, VU0360172, reduces spontaneous absence seizures in WAG/Rij rats. Neuropharmacology, 66 . pp. 330-338. ISSN 0028-3908

Male

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Mepyramine

Holden, Neil S. and Gong, W. and King, E. M. and Kaur, M. and Giembycz, M. A. and Newton, R. (2007) Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. British journal of pharmacology, 152 (6). pp. 891-902. ISSN 0007-1188

Mice

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

Mice, Inbred C57BL

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Mice, Knockout

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Middle Aged

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Models, Molecular

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Molecular Targeted Therapy

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Morpholines

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Motor Activity

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Movement

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Munc18 Proteins

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Munc18 protein

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Muscle Contraction

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

NF-?B

Holden, Neil S. and Gong, W. and King, E. M. and Kaur, M. and Giembycz, M. A. and Newton, R. (2007) Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. British journal of pharmacology, 152 (6). pp. 891-902. ISSN 0007-1188

NF-kappa B

Catley, Matthew C. and Chivers, Joanna E. and Holden, Neil S. and Barnes, Peter J. and Newton, Robert (2005) Validation of IKK beta as therapeutic target in airway inflammatory disease by adenoviral-mediated delivery of dominant-negative IKK beta to pulmonary epithelial cells. British journal of pharmacology, 145 (1). pp. 114-22. ISSN 0007-1188

King, Elizabeth M. and Kaur, Manminder and Gong, Wei and Rider, Christopher F. and Holden, Neil S. and Newton, Robert (2009) Regulation of tristetraprolin expression by interleukin-1β and dexamethasone in human pulmonary epithelial cells: Roles for nuclear factor-κB and p38 mitogen-activated protein kinase. The journal of pharmacology and experimental therapeutics, 330 (2). pp. 575-585. ISSN 0022-3565

Newton, Robert and Holden, Neil S. and Catley, Matthew C. and Oyelusi, Wale and Leigh, Richard and Proud, David and Barnes, Peter J. (2007) Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IκB kinase inhibitors. The journal of pharmacology and experimental therapeutics, 321 (2). pp. 734-42. ISSN 0022-3565

NHBE

Holden, Neil S. and Rider, C. F. and Bell, M. J. and Velayudhan, J. and King, E. M. and Kaur, M. and Salmon, M. and Giembycz, M. A. and Newton, R. (2010) Enhancement of inflammatory mediator release by beta(2)-adrenoceptor agonists in airway epithelial cells is reversed by glucocorticoid action. British journal of pharmacology, 160 (2). pp. 410-420. ISSN 0007-1188

Naphthalenes

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Nerve Net

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Neural Pathways

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Neuroglia

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Nucleic Acid Synthesis Inhibitors

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Oxazines

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

PBN

Kuroda, Satoshi and Katsura, Ken-ichiro and Hillered, Lars and Bates, Timothy E. and Siesjö, Bo K. (1996) Delayed treatment with alpha-phenyl-N-tert-butyl nitrone (PBN) attenuates secondary mitochondrial dysfunction after transient focal cerebral ischemia in the rat. Neurobiology of Disease, 3 (2). pp. 149-157. ISSN 0969-9961

Parkinson disease

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Perfusion

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Phosphinic Acids

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Photosensitizing Agents

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Piperidines

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Polyunsaturated Alkamides

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Postural Balance

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Pregnancy

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Prenatal Exposure Delayed Effects

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Psychomotor Performance

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Pulmonary epithelium

Catley, Matthew C. and Chivers, Joanna E. and Holden, Neil S. and Barnes, Peter J. and Newton, Robert (2005) Validation of IKK beta as therapeutic target in airway inflammatory disease by adenoviral-mediated delivery of dominant-negative IKK beta to pulmonary epithelial cells. British journal of pharmacology, 145 (1). pp. 114-22. ISSN 0007-1188

Pyrazoles

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Quinolines

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

R-SNARE Proteins

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

RNA, Messenger

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

RO0711401

D'Amore, V. and Santolini, I. and Celli, R. and Lionetto, L. and De Fusco, A. and Simmaco, M. and van Rijn, C. M. and Vieira, E. and Stauffer, S.R. and Conn, P. J. and Bosco, P. and Nicoletti, F. and van Luijtelaar, G. and Ngomba, R. T. (2014) Head-to head comparison of mGlu1 and mGlu5 receptor activation in chronic treatment of absence epilepsy in WAG/Rij rats. Neuropharmacology, 85 . pp. 91-103. ISSN 0028-3908

Rab protein

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Rats

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Rats, Inbred ACI

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Rats, Inbred Strains

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Rats, Mutant Strains

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Rats, Sprague-Dawley

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Rats, Wistar

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Receptor, Cannabinoid, CB1

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Receptors, Drug

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

Receptors, Metabotropic Glutamate

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Reflex

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Reverse Transcriptase Polymerase Chain Reaction

Chivers, Joanna E. and Gong, Wei and King, Elizabeth M. and Seybold, Joachim and Mak, Judith C. and Donnelly, Louise E. and Holden, Neil S. and Newton, Robert (2006) Analysis of the dissociated steroid RU24858 does not exclude a role for inducible genes in the anti-inflammatory actions of glucocorticoids. Molecular pharmacology, 70 (6). pp. 2084-2095. ISSN 0026-895X

Rimonabant

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Seizure

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Seizures

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Signal Transduction

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

Smooth muscle cells

Kelly, M. M. and King, E. M. and Rider, C. F. and Gwozd, C. and Holden, Neil S. and Eddleston, J. and Zuraw, B. and Leigh, R. and O'Byrne, P. M. and Newton, R. (2012) Corticosteroid-induced gene expression in allergen-challenged asthmatic subjects taking inhaled budesonide. British Journal of Pharmacology, 165 (6). pp. 1737-1747. ISSN 0007-1188

Spike-wave discharges

D'Amore, V. and Santolini, I. and Celli, R. and Lionetto, L. and De Fusco, A. and Simmaco, M. and van Rijn, C. M. and Vieira, E. and Stauffer, S.R. and Conn, P. J. and Bosco, P. and Nicoletti, F. and van Luijtelaar, G. and Ngomba, R. T. (2014) Head-to head comparison of mGlu1 and mGlu5 receptor activation in chronic treatment of absence epilepsy in WAG/Rij rats. Neuropharmacology, 85 . pp. 91-103. ISSN 0028-3908

Spinocerebellar Ataxias

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Spinocerebellar Ataxias, Animals

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Stress, Psychological

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Supersensitivity

HAWTHORN, M. H. and CHESSWILLIAMS, R. G. and Grassby, P. F. and BROADLEY, K. J. (1985) The use of forskolin to investigate the site of cardiac beta-adrenoreceptor supersensitivity. Journal of Autonomic Pharmacology, 5 (3). pp. 231-239. ISSN 0144-1795

Synapsins

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Synaptic Transmission

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Thalamic Nuclei

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Thalamus

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Tolerance

D'Amore, V. and Santolini, I. and Celli, R. and Lionetto, L. and De Fusco, A. and Simmaco, M. and van Rijn, C. M. and Vieira, E. and Stauffer, S.R. and Conn, P. J. and Bosco, P. and Nicoletti, F. and van Luijtelaar, G. and Ngomba, R. T. (2014) Head-to head comparison of mGlu1 and mGlu5 receptor activation in chronic treatment of absence epilepsy in WAG/Rij rats. Neuropharmacology, 85 . pp. 91-103. ISSN 0028-3908

Transactivation

Newton, Robert and Holden, Neil S. (2007) Separating transrepression and transactivation: a distressing divorce for the glucocorticoid receptor? Molecular pharmacology, 72 (4). pp. 799-809. ISSN 0026-895X

Transcription

Chivers, Joanna E. and Gong, Wei and King, Elizabeth M. and Seybold, Joachim and Mak, Judith C. and Donnelly, Louise E. and Holden, Neil S. and Newton, Robert (2006) Analysis of the dissociated steroid RU24858 does not exclude a role for inducible genes in the anti-inflammatory actions of glucocorticoids. Molecular pharmacology, 70 (6). pp. 2084-2095. ISSN 0026-895X

VU0360172

D'Amore, V. and Santolini, I. and Celli, R. and Lionetto, L. and De Fusco, A. and Simmaco, M. and van Rijn, C. M. and Vieira, E. and Stauffer, S.R. and Conn, P. J. and Bosco, P. and Nicoletti, F. and van Luijtelaar, G. and Ngomba, R. T. (2014) Head-to head comparison of mGlu1 and mGlu5 receptor activation in chronic treatment of absence epilepsy in WAG/Rij rats. Neuropharmacology, 85 . pp. 91-103. ISSN 0028-3908

D'Amore, V. and Santolini, I. and van Rijn, C.M. and Biagioni, F. and Molinaro, G. and Prete, A. and Conn, P.J. and Lindsley, C.W. and Zhou, Y. and Vinson, P.N. and Rodriguez, A.L. and Jones, C.K and Stauffer, S.R. and Nicoletti, F. and van Luijtelaar, G. and Ngomba, R.T. (2013) Potentiation of mGlu5 receptors with the novel enhancer, VU0360172, reduces spontaneous absence seizures in WAG/Rij rats. Neuropharmacology, 66 . pp. 330-338. ISSN 0028-3908

WAG/Rij rats

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

D'Amore, V. and Santolini, I. and Celli, R. and Lionetto, L. and De Fusco, A. and Simmaco, M. and van Rijn, C. M. and Vieira, E. and Stauffer, S.R. and Conn, P. J. and Bosco, P. and Nicoletti, F. and van Luijtelaar, G. and Ngomba, R. T. (2014) Head-to head comparison of mGlu1 and mGlu5 receptor activation in chronic treatment of absence epilepsy in WAG/Rij rats. Neuropharmacology, 85 . pp. 91-103. ISSN 0028-3908

D'Amore, V. and Santolini, I. and van Rijn, C.M. and Biagioni, F. and Molinaro, G. and Prete, A. and Conn, P.J. and Lindsley, C.W. and Zhou, Y. and Vinson, P.N. and Rodriguez, A.L. and Jones, C.K and Stauffer, S.R. and Nicoletti, F. and van Luijtelaar, G. and Ngomba, R.T. (2013) Potentiation of mGlu5 receptors with the novel enhancer, VU0360172, reduces spontaneous absence seizures in WAG/Rij rats. Neuropharmacology, 66 . pp. 330-338. ISSN 0028-3908

WIN55,212, Animals

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Western blotting

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Western blotting, Amino Acids

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Wistar albino Glaxo rat

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Xanthenes

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

absence

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

acetylcysteine

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

adenosine triphosphatase (potassium)

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

adolescent

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

adult

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

agmatine

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

algorithm

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

alpha 1 adrenergic receptor blocking agent

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

amantadine

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

amenamevir

Biswas, Subhajit and Sukla, Soumi and Field, Hugh J. (2014) Helicase-primase inhibitors for herpes simplex virus: looking to the future of non-nucleoside inhibitors for treating herpes virus infections. Future Medicinal Chemistry, 6 (1). pp. 45-55. ISSN 1756-8919

aminolevulinic acid

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

aminolevulinic acid hexyl ester

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

analysis of variance

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

anandamide

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

animal

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

animal experiment

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

animal model

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

animal tissue

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

anti-inflammatories

Newton, Robert and Holden, Neil S. (2007) Separating transrepression and transactivation: a distressing divorce for the glucocorticoid receptor? Molecular pharmacology, 72 (4). pp. 799-809. ISSN 0026-895X

anti-inflammatory effects

Chivers, Joanna E. and Gong, Wei and King, Elizabeth M. and Seybold, Joachim and Mak, Judith C. and Donnelly, Louise E. and Holden, Neil S. and Newton, Robert (2006) Analysis of the dissociated steroid RU24858 does not exclude a role for inducible genes in the anti-inflammatory actions of glucocorticoids. Molecular pharmacology, 70 (6). pp. 2084-2095. ISSN 0026-895X

antidepressant activity

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

antiestrogen

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

antiviral

Biswas, Subhajit and Sukla, Soumi and Field, Hugh J. (2014) Helicase-primase inhibitors for herpes simplex virus: looking to the future of non-nucleoside inhibitors for treating herpes virus infections. Future Medicinal Chemistry, 6 (1). pp. 45-55. ISSN 1756-8919

anxiety

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

area under the curve

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

article

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

atypical antipsychotic agent

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

autism

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

azd 2066

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

basimglurant

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

behavior

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

benzoxazine derivative

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

beta-agonists

Chess-Williams, RG and Grassby, Paul and Culling, W. and Penny, W. and Broadley, K. J. and Sheridan, D. J. (1985) Cardiac postjunctional supersensitivity to β-agonists after chronic chemical sympathectomy with 6-hydroxydopamine. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 329 (2). pp. 162-166. ISSN 0028-1298

beta2-adrenoceptor agonists

Holden, Neil S. and Rider, C. F. and Bell, M. J. and Velayudhan, J. and King, E. M. and Kaur, M. and Salmon, M. and Giembycz, M. A. and Newton, R. (2010) Enhancement of inflammatory mediator release by beta(2)-adrenoceptor agonists in airway epithelial cells is reversed by glucocorticoid action. British journal of pharmacology, 160 (2). pp. 410-420. ISSN 0007-1188

Rider, Christopher F. and King, Elizabeth M. and Holden, Neil S. and Giembycz, Mark A. and Newton, Robert (2011) Inflammatory stimuli inhibit glucocorticoid-dependent transactivation in human pulmonary epithelial cells: rescue by long-acting beta2-adrenoceptor agonists. Journal of Pharmacology and Experimental Therapeutics, 338 (3). pp. 860-869. ISSN 0022-3565

bioavailability

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

blood

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

body posture

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

brain cortex

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

brain damage

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

brain infarction size

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

brain ischemia

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

brain level

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

brain protection

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

calcium cell level

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

calcium ion

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

calcium transport

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

cannabinoid 1 receptor

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

cannabinoid 1 receptor agonist

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

cannabis addiction

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

carbon

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

carbon 14

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

caudate nucleus

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

central nervous system disease

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

cerebellum disease

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

cerebrovascular accident

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

cinnabarinic acid

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

clinical trial

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

cocaine dependence

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

conference paper

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

confidence interval

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

controlled clinical trial

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

controlled study

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

convalescence

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

crossover procedure

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

cytochrome P450 3A4

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

cytokines

Catley, Matthew C. and Chivers, Joanna E. and Holden, Neil S. and Barnes, Peter J. and Newton, Robert (2005) Validation of IKK beta as therapeutic target in airway inflammatory disease by adenoviral-mediated delivery of dominant-negative IKK beta to pulmonary epithelial cells. British journal of pharmacology, 145 (1). pp. 114-22. ISSN 0007-1188

data analysis

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

depolarization

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

depression

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

dexamethasones

King, Elizabeth M. and Kaur, Manminder and Gong, Wei and Rider, Christopher F. and Holden, Neil S. and Newton, Robert (2009) Regulation of tristetraprolin expression by interleukin-1β and dexamethasone in human pulmonary epithelial cells: Roles for nuclear factor-κB and p38 mitogen-activated protein kinase. The journal of pharmacology and experimental therapeutics, 330 (2). pp. 575-585. ISSN 0022-3565

dextro aspartic acid

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

diabetes mellitus

Siriwardena, A. Niroshan and Middlemass, Jo B. and Ward, Kate and Wilkinson, Carol (2009) Drivers for change in primary care of diabetes following a protected learning time educational event: interview study of practitioners. BMC Medical Education, 8 (4). pp. 1-9. ISSN 1472-6920

diazepam

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

diazoxide

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

dipraglurant

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

disease model

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

dose calculation

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

dose response

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

dose time effect relation

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

drug absorption

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

drug administration route

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

drug bioavailability

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

drug blood level

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

drug clearance

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

drug cost

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

drug dependence

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

drug derivative

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

drug design

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

drug determination

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

drug distribution

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

drug dose comparison

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

drug effect

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

drug effects

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

drug efficacy

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

drug half life

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

drug mechanism

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

drug metabolite

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

drug potentiation

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

drug receptor binding

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

drug research

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

drug safety

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

drug targeting

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

drug tolerability

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

drug-resistance

Biswas, Subhajit and Sukla, Soumi and Field, Hugh J. (2014) Helicase-primase inhibitors for herpes simplex virus: looking to the future of non-nucleoside inhibitors for treating herpes virus infections. Future Medicinal Chemistry, 6 (1). pp. 45-55. ISSN 1756-8919

dyskinesia

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

educational intervention

Siriwardena, A. Niroshan and Middlemass, Jo B. and Ward, Kate and Wilkinson, Carol (2009) Drivers for change in primary care of diabetes following a protected learning time educational event: interview study of practitioners. BMC Medical Education, 8 (4). pp. 1-9. ISSN 1472-6920

efaroxan

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

electrocorticography

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

electroencephalogram

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

electroencephalography

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

electromyography

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

endothelin 1

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

endothelin 1, age

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

endothelium cell

Newton, Robert and Holden, Neil S. (2007) Separating transrepression and transactivation: a distressing divorce for the glucocorticoid receptor? Molecular pharmacology, 72 (4). pp. 799-809. ISSN 0026-895X

epithelial cells

Kelly, M. M. and King, E. M. and Rider, C. F. and Gwozd, C. and Holden, Neil S. and Eddleston, J. and Zuraw, B. and Leigh, R. and O'Byrne, P. M. and Newton, R. (2012) Corticosteroid-induced gene expression in allergen-challenged asthmatic subjects taking inhaled budesonide. British Journal of Pharmacology, 165 (6). pp. 1737-1747. ISSN 0007-1188

erythromycin

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

excitatory amino acid transporter

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

excitatory amino acid transporter 1

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

female

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

flow

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

fluconazole

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

food and drug administration

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

forelimb

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

fragile X syndrome

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

fura 2

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

gene

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

gene deletion

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

gene expression

Newton, Robert and Holden, Neil S. (2007) Separating transrepression and transactivation: a distressing divorce for the glucocorticoid receptor? Molecular pharmacology, 72 (4). pp. 799-809. ISSN 0026-895X

gene expression regulation

Chivers, Joanna E. and Gong, Wei and King, Elizabeth M. and Seybold, Joachim and Mak, Judith C. and Donnelly, Louise E. and Holden, Neil S. and Newton, Robert (2006) Analysis of the dissociated steroid RU24858 does not exclude a role for inducible genes in the anti-inflammatory actions of glucocorticoids. Molecular pharmacology, 70 (6). pp. 2084-2095. ISSN 0026-895X

King, Elizabeth M. and Kaur, Manminder and Gong, Wei and Rider, Christopher F. and Holden, Neil S. and Newton, Robert (2009) Regulation of tristetraprolin expression by interleukin-1β and dexamethasone in human pulmonary epithelial cells: Roles for nuclear factor-κB and p38 mitogen-activated protein kinase. The journal of pharmacology and experimental therapeutics, 330 (2). pp. 575-585. ISSN 0022-3565

Newton, Robert and Holden, Neil S. and Catley, Matthew C. and Oyelusi, Wale and Leigh, Richard and Proud, David and Barnes, Peter J. (2007) Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IκB kinase inhibitors. The journal of pharmacology and experimental therapeutics, 321 (2). pp. 734-42. ISSN 0022-3565

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

gene inactivation

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

gene transcription

Newton, Robert and Holden, Neil S. (2007) Separating transrepression and transactivation: a distressing divorce for the glucocorticoid receptor? Molecular pharmacology, 72 (4). pp. 799-809. ISSN 0026-895X

general practice

Siriwardena, A. Niroshan and Middlemass, Jo B. and Ward, Kate and Wilkinson, Carol (2009) Drivers for change in primary care of diabetes following a protected learning time educational event: interview study of practitioners. BMC Medical Education, 8 (4). pp. 1-9. ISSN 1472-6920

genetic absence epilepsy

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

genetic disorder

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

genetic model

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

genetics

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

glia cell

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

glucocorticoids

Chivers, Joanna E. and Gong, Wei and King, Elizabeth M. and Seybold, Joachim and Mak, Judith C. and Donnelly, Louise E. and Holden, Neil S. and Newton, Robert (2006) Analysis of the dissociated steroid RU24858 does not exclude a role for inducible genes in the anti-inflammatory actions of glucocorticoids. Molecular pharmacology, 70 (6). pp. 2084-2095. ISSN 0026-895X

Newton, Robert and Holden, Neil S. (2007) Separating transrepression and transactivation: a distressing divorce for the glucocorticoid receptor? Molecular pharmacology, 72 (4). pp. 799-809. ISSN 0026-895X

glutamic acid

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

glycoprotein P

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

granulocyte/macrophage colony-stimulating factor (GM-CSF)

Catley, Matthew C. and Chivers, Joanna E. and Holden, Neil S. and Barnes, Peter J. and Newton, Robert (2005) Validation of IKK beta as therapeutic target in airway inflammatory disease by adenoviral-mediated delivery of dominant-negative IKK beta to pulmonary epithelial cells. British journal of pharmacology, 145 (1). pp. 114-22. ISSN 0007-1188

half life time

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

happy puppet syndrome

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

hexaminolevulinate c 14

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

high performance liquid chromatography

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

hippocampus

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

human

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

human cell

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

human experiment

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

hydrolysis

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

idazoxan

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

imidazoline derivative

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

imidazoline receptor

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

immunoblotting

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

immunohistochemistry

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

in situ hybridization

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

in vivo study

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

insulin

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

insulin release

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

interleukin 1beta

King, Elizabeth M. and Kaur, Manminder and Gong, Wei and Rider, Christopher F. and Holden, Neil S. and Newton, Robert (2009) Regulation of tristetraprolin expression by interleukin-1β and dexamethasone in human pulmonary epithelial cells: Roles for nuclear factor-κB and p38 mitogen-activated protein kinase. The journal of pharmacology and experimental therapeutics, 330 (2). pp. 575-585. ISSN 0022-3565

Newton, Robert and Holden, Neil S. and Catley, Matthew C. and Oyelusi, Wale and Leigh, Richard and Proud, David and Barnes, Peter J. (2007) Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IκB kinase inhibitors. The journal of pharmacology and experimental therapeutics, 321 (2). pp. 734-42. ISSN 0022-3565

interleukin 6

Newton, Robert and Holden, Neil S. and Catley, Matthew C. and Oyelusi, Wale and Leigh, Richard and Proud, David and Barnes, Peter J. (2007) Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IκB kinase inhibitors. The journal of pharmacology and experimental therapeutics, 321 (2). pp. 734-42. ISSN 0022-3565

interleukin 8

Newton, Robert and Holden, Neil S. and Catley, Matthew C. and Oyelusi, Wale and Leigh, Richard and Proud, David and Barnes, Peter J. (2007) Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IκB kinase inhibitors. The journal of pharmacology and experimental therapeutics, 321 (2). pp. 734-42. ISSN 0022-3565

interviews

Siriwardena, A. Niroshan and Middlemass, Jo B. and Ward, Kate and Wilkinson, Carol (2009) Drivers for change in primary care of diabetes following a protected learning time educational event: interview study of practitioners. BMC Medical Education, 8 (4). pp. 1-9. ISSN 1472-6920

intestine contraction

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

intestine perfusion

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

intravesical drug administration

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

ketamine

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

kynurenine

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

large intestine

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

levacecarnine

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

ligand

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

lipopolysaccharide

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

liquid chromatography

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

long term depression

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

mGlu5 receptor

D'Amore, V. and Santolini, I. and van Rijn, C.M. and Biagioni, F. and Molinaro, G. and Prete, A. and Conn, P.J. and Lindsley, C.W. and Zhou, Y. and Vinson, P.N. and Rodriguez, A.L. and Jones, C.K and Stauffer, S.R. and Nicoletti, F. and van Luijtelaar, G. and Ngomba, R.T. (2013) Potentiation of mGlu5 receptors with the novel enhancer, VU0360172, reduces spontaneous absence seizures in WAG/Rij rats. Neuropharmacology, 66 . pp. 330-338. ISSN 0028-3908

male

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

mass spectrometry

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

mavoglurant

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

maze test

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

medical literature

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

messenger RNA

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

metabolism

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

metabolite

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

metabotropic receptor

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

metabotropic receptor 1

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

metabotropic receptor 1alpha

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

metabotropic receptor 2

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

metabotropic receptor 3

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

metabotropic receptor 4

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

metabotropic receptor 5

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

metabotropic receptor 7

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

metabotropic receptor 8

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

metabotropic receptor 8, absence

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

metabotropic receptor agonist

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

metabotropic receptor antagonist

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

metabotropic receptor, absence

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

methodology

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

microdosing

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

microfluorometry

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

midazolam

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

middle aged, Administration, Intravesical

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

middle cerebral artery

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

middle cerebral artery occlusion

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

mitochondria

Kuroda, Satoshi and Katsura, Ken-ichiro and Hillered, Lars and Bates, Timothy E. and Siesjö, Bo K. (1996) Delayed treatment with alpha-phenyl-N-tert-butyl nitrone (PBN) attenuates secondary mitochondrial dysfunction after transient focal cerebral ischemia in the rat. Neurobiology of Disease, 3 (2). pp. 149-157. ISSN 0969-9961

molecular model

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

molecular pathology

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

molecularly targeted therapy

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

morpholine derivative

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

mouse

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

movement (physiology)

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

mutagenesis

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

mutant

Biswas, Subhajit and Sukla, Soumi and Field, Hugh J. (2014) Helicase-primase inhibitors for herpes simplex virus: looking to the future of non-nucleoside inhibitors for treating herpes virus infections. Future Medicinal Chemistry, 6 (1). pp. 45-55. ISSN 1756-8919

n methyl dextro aspartic acid receptor

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

n phenyl 7 (hydroxyimino)cyclopropabchromen 1a caboxamide

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

naphthalene derivative

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

nerve cell

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

nervous system electrophysiology

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

neuroleptic agent

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

neuromodulation

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

neuroprotection

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

neurotransmitter release

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

nonhuman

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

normal human

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

oscillation

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

p38 Mitogen-Activated Protein Kinases

King, Elizabeth M. and Kaur, Manminder and Gong, Wei and Rider, Christopher F. and Holden, Neil S. and Newton, Robert (2009) Regulation of tristetraprolin expression by interleukin-1β and dexamethasone in human pulmonary epithelial cells: Roles for nuclear factor-κB and p38 mitogen-activated protein kinase. The journal of pharmacology and experimental therapeutics, 330 (2). pp. 575-585. ISSN 0022-3565

pancreas islet

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

parvalbumin

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

pathogenesis

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

pathology

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

pathophysiology

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

patient participation

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

phase 2 clinical trial (topic)

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

phentolamine

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

phentolamine mesylate, animal tissue

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

photosensitizing agent, absence of side effects

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

piperidine derivative

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

polyphosphoinositide, absence

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

pomaglumetad methionil

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

practice guideline

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

prenatal stress

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

primary care

Siriwardena, A. Niroshan and Middlemass, Jo B. and Ward, Kate and Wilkinson, Carol (2009) Drivers for change in primary care of diabetes following a protected learning time educational event: interview study of practitioners. BMC Medical Education, 8 (4). pp. 1-9. ISSN 1472-6920

priority journal

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

priority journal, Administration, Oral

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

priority journal, Adrenergic alpha-Antagonists

Shepherd, R. M. and Hashmi, M. N. and Kane, C. and Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

pritelivir

Biswas, Subhajit and Sukla, Soumi and Field, Hugh J. (2014) Helicase-primase inhibitors for herpes simplex virus: looking to the future of non-nucleoside inhibitors for treating herpes virus infections. Future Medicinal Chemistry, 6 (1). pp. 45-55. ISSN 1756-8919

prostaglandin GH synthase

Catley, Matthew C. and Chivers, Joanna E. and Holden, Neil S. and Barnes, Peter J. and Newton, Robert (2005) Validation of IKK beta as therapeutic target in airway inflammatory disease by adenoviral-mediated delivery of dominant-negative IKK beta to pulmonary epithelial cells. British journal of pharmacology, 145 (1). pp. 114-22. ISSN 0007-1188

protected learning time

Siriwardena, A. Niroshan and Middlemass, Jo B. and Ward, Kate and Wilkinson, Carol (2009) Drivers for change in primary care of diabetes following a protected learning time educational event: interview study of practitioners. BMC Medical Education, 8 (4). pp. 1-9. ISSN 1472-6920

protein expression

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

protein function

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

protein localization

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

publication

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

putamen

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

pyrazole derivative, animal experiment

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

qualitative research

Siriwardena, A. Niroshan and Middlemass, Jo B. and Ward, Kate and Wilkinson, Carol (2009) Drivers for change in primary care of diabetes following a protected learning time educational event: interview study of practitioners. BMC Medical Education, 8 (4). pp. 1-9. ISSN 1472-6920

rab3A GTP-Binding Protein

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

radiation dose

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

radioactivity

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

radiopharmaceutical agent

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

rat

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

rat strain, Analysis of Variance

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

receptor down regulation

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

regulatory mechanism

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

respiratory mucosa

King, Elizabeth M. and Kaur, Manminder and Gong, Wei and Rider, Christopher F. and Holden, Neil S. and Newton, Robert (2009) Regulation of tristetraprolin expression by interleukin-1β and dexamethasone in human pulmonary epithelial cells: Roles for nuclear factor-κB and p38 mitogen-activated protein kinase. The journal of pharmacology and experimental therapeutics, 330 (2). pp. 575-585. ISSN 0022-3565

review

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

rhein

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

rimonabant, absence

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

ro 0711401

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

ro 4419513

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

ro 4432717

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

schizophrenia

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

seizure

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

sennoside, animal experiment

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

sensitivity analysis

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

sensorimotor function

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

sensorimotor integration

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

serotonin 2A receptor

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

signal transduction

Catley, Matthew C. and Chivers, Joanna E. and Holden, Neil S. and Barnes, Peter J. and Newton, Robert (2005) Validation of IKK beta as therapeutic target in airway inflammatory disease by adenoviral-mediated delivery of dominant-negative IKK beta to pulmonary epithelial cells. British journal of pharmacology, 145 (1). pp. 114-22. ISSN 0007-1188

somatosensory cortex

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

spike

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

spike wave

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

spike wave discharge

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

statistical analysis

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

stereotactic device

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

strain gauge transducer

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

striate cortex

Moyanova, S. G. and Mitreva, R. G. and Kortenska, L. V. and Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

syn 119

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

synapse vesicle

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

synapsin I

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

synapsin II

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

synaptic transmission

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

synaptobrevin

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

synaptophysin

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

synaptosomal associated protein 25

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

synaptosome

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

syntaxin 1

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

tandem mass spectrometry

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

tandem mass spectrometry, Animals

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

thalamocortical tract

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

thalamocortical tract, Animals

Ngomba, Richard Teke and Santolini, I. and Salt, T. E. and Ferraguti, F. and Battaglia, G. and Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

thalamus

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

thalamus nucleus

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Van Rijn, C. M. and Gaetani, S. and Santolini, I. and Badura, A. and Gabova, A. and Fu, J. and Watanabe, M. and Cuomo, V. and Van Luijtelaar, G. and Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

thalamus reticular nucleus

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

tobacco dependence

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

tolbutamide

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

toxicology

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

transducer, Animal

Rumsey, R. D. E. and Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

tristetrapolin

King, Elizabeth M. and Kaur, Manminder and Gong, Wei and Rider, Christopher F. and Holden, Neil S. and Newton, Robert (2009) Regulation of tristetraprolin expression by interleukin-1β and dexamethasone in human pulmonary epithelial cells: Roles for nuclear factor-κB and p38 mitogen-activated protein kinase. The journal of pharmacology and experimental therapeutics, 330 (2). pp. 575-585. ISSN 0022-3565

tubercidin

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

unclassified drug

Klem, B. and Lappin, Graham and Nicholson, S. and Van De Wetering, J. and De Vries, D. E. and Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

unclassified drug, animal cell

Fazio, F. and Lionetto, L. and Molinaro, G. and Bertrand, H.O. and Acher, F. and Ngomba, R.T. and Notartomaso, S. and Curini, M. and Rosati, O. and Scarselli, P. and Di Marco, R.a and Battaglia, G. and Bruno, V. and Simmaco, M. and Pin, J.P. and Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

unclassified drug, animal experiment

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

ventroposterolateral nucleus, Allosteric Regulation

Ngomba, R. T. and Santolini, I. and Biagioni, F. and Molinaro, G. and Simonyi, A. and Van Rijn, C. M. and D'Amore, V. and Mastroiacovo, F. and Olivieri, G. and Gradini, R. and Ferraguti, F. and Battaglia, G. and Bruno, V. and Puliti, A. and Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

ventroposteromedial thalamic nucleus, Anandamide

Citraro, R. and Russo, E. and Ngomba, R.T. and Nicoletti, F. and Scicchitano, F. and Whalley, B.J. and Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

vesicular glutamate transporter 1, animal experiment

Marrocco, J. and Mairesse, J. and Ngomba, R.T. and Silletti, V. and Van Camp, G. and Bouwalerh, H. and Summa, M. and Pittaluga, A. and Nicoletti, F. and Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

volunteer

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

vu 0360172

Nicoletti, F. and Bruno, V. and Ngomba, R. T and Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

warfarin

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

wild type, Animals

Moyanova, S. G. and Mastroiacovo, F. and Kortenska, L. V. and Mitreva, R. G. and Fardone, E. and Santolini, I. and Sobrado, M. and Battaglia, G. and Bruno, V. and Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

zk 253, adult

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

zk 253, area under the curve

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

This list was generated on Thu Feb 11 12:31:42 2016 GMT.