Article

Abdel-Razaq, W. and Bates, T. E. and Kendall, D. A. (2007) The effects of antidepressants on cyclic AMP-response element-driven gene transcription in a model cell system. Biochemical Pharmacology, 73 (12). pp. 1995-2003. ISSN 0006-2952

Ali, Hany S. M. and York, Peter and Blagden, Nicholas (2009) Preparation of hydrocortisone nanosuspension through a bottom-up nanoprecipitation technique using microfluidic reactors. International Journal of Pharmaceutics, 375 (1-2). pp. 107-113. ISSN 0378-5173

Allen, Kathryn L. and Almeida, Angeles and Bates, Timothy E. and Clark, John B. (1995) Changes of respiratory chain activity in mitochondrial and synaptosomal fractions isolated from the gerbil brain after graded ischaemia. Journal of neurochemistry, 64 (5). pp. 2222-2229. ISSN 0022-3042

Almeida, A. and Brooks, K. J. and Sammut, I. and Keelan, J. and Davey, G. P. and Clark, J. B. and Bates, T. E. (1995) Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain. Developmental Neuroscience, 17 (4). pp. 212-218. ISSN 0378-5866

Almeida, Angeles and Allen, Kathryn L. and Bates, TImothy E. and Clark, John B. (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. Journal of neurochemistry, 65 (4). pp. 1698-1703. ISSN 0022-3042

Athanasiou, Andriani and Clarke, Anna B. and Turner, Amy E. and Kumaran, Nethia M. and Vakilpour, Sara and Smith, Paul A. and Bagiokou, Dimitra and Bradshaw, Tracey D. and Westwell, Andrew D. and Fang, Lin and Lobo, Dileep N. and Constantinescu, Cris S. and Calabrese, Vittorio and Loesch, Andrzej and Alexander, Stephen P. H. and Clothier, Richard H. and Kendall, David A. and Bates, Timothy E. (2007) Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications, 364 (1). pp. 131-137. ISSN 0006-291x

Athanasiou, Andriani and Smith, Paul A. and Vakilpour, Sara and Kumaran, Nethia M. and Turner, Amy E. and Bagiokou, Dimitra and Layfield, Robert and Ray, David E. and Westwell, Andrew D. and Alexander, Stephen P. H. and Kendall, David A. and Lobo, Dileep N. and Watson, Susan A. and Lophatanon, Artitaya and Muir, Kenneth A. and Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

Bates, T E and Almeida, A and Heales, S J and Clark, J B (1994) Postnatal development of the complexes of the electron transport chain in isolated rat brain mitochondria. Developmental neuroscience, 16 (5-6). pp. 321-7. ISSN 0378-5866

Bates, T. E and Loesch, A. and Burnstock, G. and Clark, J. B. (1995) Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver. Biochemical and biophysical research communications, 213 (3). pp. 896-900. ISSN 0006-291X

Bates, T. E. and Heales, S. J. and Davies, S. E. and Boakye, P. and Clark, J. B. (1994) Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. Journal of neurochemistry, 63 (2). pp. 640-648. ISSN 0022-3042

Bates, T. E. and Loesch, A. and Burnstock, G. and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochemical and biophysical research communications, 218 (1). pp. 40-44. ISSN 0006-291X

Bates, T. E. and Williams, S. R. and Busza, A. L. and Gadian, D. G. and Proctor, E. (1988) A 31P nuclear magnetic resonance study in vivo of metabolic abnormalities in rats with acute liver failure. NMR in biomedicine, 1 (2). pp. 67-73. ISSN 0952-3480

Bates, Timothy E. and Williams, Stephen R. and Gadian, David G. (1989) Phosphodiesters in the liver: the effect of field strength on the 31P signal. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 12 (1). pp. 145-150. ISSN 0740-3194

Bates, Timothy E. and Williams, Stephen R. and Kauppinen, Risto A. and Gadian, David G. (1989) Observation of cerebral metabolites in an animal model of acute liver failure in vivo: a 1H and 31P nuclear magnetic resonance study. Journal of neurochemistry, 53 (1). pp. 102-10. ISSN 0022-3042

Blagden, N. and Davey, R. J. and Rowe, R. and Roberts, R. (1998) Disappearing polymorphs and the role of reaction by-products: the case of sulphathiazole. International Journal of Pharmaceutics, 172 (1-2). pp. 169-177. ISSN 0378-5173

Broadley, K. J. and Chess-Williams, R. G. and Grassby, P. F. (1986) A physiological basis for subclassifying beta-adrenoceptors examined by chemical sympathectomy of guinea-pigs. Journal of Physiology, 373 (1). pp. 367-378. ISSN 0022-3751

Broadley, K. J. and Williams, R. G. and Hawthorn, M. H. and Grassby, Paul (1984) Mechanisms of cardiac supersensitivity to sympathomimetic amines. Methods and Findings in Experimental and Clinical Pharmacology, 6 (4). pp. 179-186. ISSN 0379-0355

Broadley, Kenneth J. and Grassby, Paul F. (1985) Alpha- and beta-adrenoceptor-mediated responses of the guinea-pig ileum and the effects of neuronal uptake inhibition. Naunyn-Schmiedeberg's Archives of Pharmacology, 331 (4). pp. 316-323. ISSN 0028-1298

Brooks, K. J. and Kauppinen, R. A. and Williams, S. R. and Bachelard, H. S. and Bates, T. E. and Gadian, D. G. (1989) Ammonia causes a drop in intracellular pH in metabolizing cortical brain slices. A [31P]- and [1H]nuclear magnetic resonance study. Neuroscience, 33 (1). pp. 185-192. ISSN 0306-4522

Brooks, Keith J. and Hargreaves, Iain P. and Bates, Timothy E. (2008) Protection of respiratory chain enzymes from ischaemic damage in adult rat brain slices. Neurochemical research, 33 (9). pp. 1711-1716. ISSN 0364-3190

Calabrese, Vittorio and Bates, Timothy E. and Mancuso, Cesare and Cornelius, Carolin and Ventimiglia, Bernardo and Cambria, Maria Teresa and Di Renzo, Laura and De Lorenzo, Antonino and Dinkova-Kostova, Albena T. (2008) Curcumin and the cellular stress response in free radical-related diseases. Molecular Nutrition & Food Research, 52 (9). pp. 1062-1073. ISSN 1613-4125

Calabrese, Vittorio and Cornelius, Carolin and Mancuso, Cesare and Pennisi, Giovanni and Calafato, Stella and Bellia, Francesco and Bates, Timothy E. and Giuffrida Stella, Anna Maria and Schapira, Tony and Dinkova Kostova, Albena T. and Rizzarelli, Enrico (2008) Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity. Neurochemical Research, 33 (12). pp. 2444-2471. ISSN 0364-3190

Casettari, Luca and Vllasaliu, Driton and Castagnino, Enzo and Stolnik, Snjezana and Howdle, Steven and Illum, Lisbeth (2012) PEGylated chitosan derivatives: synthesis, characterizations and pharmaceutical applications. Progress in Polymer Science, 37 (5). pp. 659-685. ISSN 0079-6700

Casettari, Luca and Vllasaliu, Driton and Lam, Jenny K. W. and Soliman, Mahmoud and Illum, Lisbeth (2012) Biomedical applications of amino acid-modified chitosans: a review. Biomaterials, 33 (30). pp. 7565-7583. ISSN 0142-9612

Casettari, Luca and Vllasaliu, Driton and Mantovani, Guiseppe and Howdle, Steven M. and Stolnik, Snow and Illum, Lisbeth (2010) Effect of PEGylation on the toxicity and permeability enhancement of chitosan. Biomacromolecules, 11 (11). pp. 2854-2865. ISSN 1525-7797

Daley, E. and Wilkie, D. and Loesch, A. and Hargreaves, I. P. and Kendall, D. A. and Pilkington, G. J. and Bates, T. E. (2005) Chlorimipramine: a novel anticancer agent with a mitochondrial target. Biochemical and Biophysical Research Communications, 328 (2). pp. 623-632. ISSN 0006-291X

Field, Hugh J. and Biswas, Subhajit and Mohammad, Islam T. (2006) Herpesvirus latency and therapy--from a veterinary perspective. Antiviral Research, 71 (2-3). pp. 127-133. ISSN 0166-3542

Gadian, D. G. and Bates, T. E. and Williams, S. R. and Bell, J. D. and Austin, S. J. and Connelly, A. (1991) Approaches to editing, assignment and interpretation of proton spectra. NMR in biomedicine, 4 (2). pp. 85-89. ISSN 0952-3480

Heales, S. J. and Davies, S. E. and Bates, T. E. and Clark, J. B. (1995) Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration. Neurochemical research, 20 (1). pp. 31-38. ISSN 0364-3190

Lappin, Graham and Garner, R. Colin (2004) Current perspectives of 14C-isotope measurement in biomedical accelerator mass spectrometry. Analytical and Bioanalytical Chemistry, 378 (2). pp. 356-364. ISSN 1618-2642

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Mancuso, Cesare and Bates, Timothy E. and Butterfield, D. Allan and Calafato, Stella and Cornelius, Carolin and De Lorenzo, Antonino and Dinkova Kostova, Albena T. and Calabrese, Vittorio (2007) Natural antioxidants in Alzheimer's disease. Expert Opinion on Investigational Drugs, 16 (12). pp. 1921-1931. ISSN 1354-3784

Moradi, Emilia and Vllasaliu, Driton and Garnett, Martin and Falcone, Franco and Stolnik, Snow (2012) Ligand density and clustering effects on endocytosis of folate modified nanoparticles. RSC Advances, 2 (7). pp. 3025-3033. ISSN 2046-2069

Murphy, Elizabeth J. and Bates, Timothy E. and Williams, Stephen R. and Watson, Tracey and Brindle, Kevin M. and Rajagopalan, Bheeshma and Radda, George K. (1992) Endoplasmic reticulum: the major contributor to the PDE peak in hepatic 31P-NMR spectra at low magnetic field strengths. Biochimica et biophysica acta: biomembranes, 1111 (1). pp. 51-58. ISSN 0005-2736

Pardon, Marie-Christine and Sarmad, Sarir and Rattray, Ivan and Bates, Timothy E. and Scullion, Gillian A. and Marsden, Charles A. and Barrett, David A. and Lowe, James and Kendall, David A. (2009) Repeated novel cage exposure-induced improvement of early Alzheimer's-like cognitive and amyloid changes in TASTPM mice is unrelated to changes in brain endocannabinoids levels. Neurobiology of Aging, 30 (7). pp. 1099-1113. ISSN 0197-4580

Prosser, D. and Allman, M. and Grassby, Paul (1998) Oral transmucosal fentanyl. Anaesthesia, 53 (10). p. 1030. ISSN 0003-2409

Rosin, Claudia and Bates, Timothy E. and Skaper, Stephen D. (2004) Excitatory amino acid induced oligodendrocyte cell death in vitro: receptor-dependent and -independent mechanisms. Journal of Neurochemistry, 90 (5). pp. 1173-1185. ISSN 0022-3042

Rosin, Claudia and Colombo, Sergio and Calver, Andrew A. and Bates, Timothy E. and Skaper, Stephen D. (2005) Dopamine D2 and D3 receptor agonists limit oligodendrocyte injury caused by glutamate oxidative stress and oxygen/glucose deprivation. Glia, 52 (4). pp. 336-343. ISSN 0894-1491

Vllasaliu, Driton and Alexander, Cameron and Garnett, Martin and Eaton , Mike and Stolnik, Snow (2012) Fc-mediated transport of nanoparticles across airway epithelial cell layers. Journal of Controlled Release, 158 (3). pp. 479-486. ISSN 0168-3659

Vllasaliu, Driton and Casettari, Luca and Bonacucina, Giulia and Cespi, Marco (2013) Folic acid conjugated chitosan nanoparticles for tumor targeting of therapeutic and imaging agents. Pharmaceutical Nanotechnology . ISSN 2211-7385 (In Press)

Vllasaliu, Driton and Casettari, Luca and Fowler, Robyn and Exposito-Harris, Ruth and Garnett, Martin and Illum, Lisbeth and Stolnik, Snow (2012) Absorption-promoting effects of chitosan in airway and intestinal cell lines: a comparative study. International Journal of Pharmaceutics, 430 (1-2). pp. 151-160. ISSN 0378-5173

Vllasaliu, Driton and Exposito-Harris, Ruth and Heras, Angeles and Casettari, Luca and Garnett, Martin and Illum, Lisbeth and Stolnik, Snow (2010) Tight junction modulation by chitosan nanoparticles: comparison with chitosan solution. International Journal of Pharmaceutics, 400 (1-2). pp. 183-193. ISSN 0378-5173

Vllasaliu, Driton and Fowler, Robyn and Garnett, Martin and Eaton , Mike and Stolnik, Snow (2011) Barrier characteristics of epithelial cultures modelling the airway and intestinal mucosa: a comparison. Biochemical and Biophysical Research Communications, 415 (4). pp. 579-585. ISSN 0006-291X

Vllasaliu, Driton and Shubber, Saif and Fowler, Robyn and Garnett, Martin and Alexander, Cameron and Stolnik, Snow (2013) Epithelial toxicity of alkylglycoside surfactants. Journal of Pharmaceutical Sciences, 102 (1). pp. 114-125. ISSN 0975-1459

Vllasaliu, Driton and Shubber, Saif and Garnett, Martin and Alexander, Cameron and Eaton, Mike and Stolnik, Snow (2012) Evaluation of calcium depletion as a strategy for enhancement of mucosal absorption of macromolecules. Biochemical and Biophysical Research Communications, 418 (1). pp. 128-133. ISSN 0006-291X

van Ravenzwaay, B. and Hardwick, T. D. and Needham, D. and Pethen, S. and Lappin, G. J. (2003) Comparative metabolism of 2,4-dichlorophenoxyacetic acid (2,4-D) in rat and dog. Xenobiotica: the fate of foreign compounds in biological systems, 33 (8). pp. 805-21. ISSN 0049-8254

Book Section

Lappin, Graham (2011) Microdosing: pharmacokinetic and metabolism data early in the drug development process. In: Pharmacokinetics in drug development: advanves and applications. Pharmacokinetics in Drug Development (3). Springer, New York. ISBN 9781441979377

Lappin, Graham (2010) Pharmacokinetics II: 14C-labelled microdosing in assessing drug pharmacokinetics at phase-0. In: Clinical Pharmacology, Current Topics and Case Studies. Springer, pp. 155-165. ISBN 9783709101438

Lappin, Graham and Tampion, J. and Stride, J. (1989) The biotransformation of monoterpenoids by tissue plant culture. In: Secondary metabolism in plant cell cultures. Cambridge University Press. ISBN UNSPECIFIED