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(E) - capsaicin 1-methyl-4-phenylpyridinium 1H 2 amino 4 nitrophenol 2 propanol 31P 4 nitrophenol 5-IAI AEA AFM AMPA ATP Absorption enhancement Accelerator mass spectrometry Acid condition Acid-base complexation reaction Adolescent Adult Aged Aged, 80 and over Alkylation Alkylglycosides Alkynes Allium Allium cepa Allium sativum Alzheimer's Amino acid Ammonia Antibiosis Anticoagulants Antioxidants Area Under Curve Artificial organs Aspergillus fumigatu Azides BSO Bacteriocins Basement membrane Batch Cell Culture Techniques Biocompatibility Bioconjugation} Biological Markers Biomarkers Biosynthesis Brain Brain Slices Bronchial alveolar lavage Butanols Byproducts CHO cells Caco-2 Caco-2 cells Calcium depletion Calu-3 Calu-3 cells Carbon Radioisotopes Carbon-Sulfur Lyases Cardiac Catalysis Cell adhesion Cell contraction Cell mechanic Cell monolayers Cell surface morphology Cell surface roughness Cells Cells adhesion Cellular stress response Cellular uptake Characterisation Charge transfer Chemical gas sensor Chemistry Chemistry, Pharmaceutical Chitosan Cholesteryl esters Chromatography, Liquid Cinchona pubescens Click reaction Complex I Complexes Computer simulation Cross-Over Studies Crystal engineering Crystal interfaces Crystal structure Crystallization Crystallography, X-Ray Crystals Cycloaddition D2 receptor D3 receptor DNA DNA Virus DNA methylation DNA-protein interactions Delta-9-tetrahydrocannabinol Derivatisation Derivative Diaminopyrimidine antibiotic Disease Progression Dissolution Dissolution rates Dodecylmaltoside Dog Dose-Response Relationship, Drug Drug Design Drug Monitoring Drug Stability Drug Storage Drug delivery Drug products Drug products plants Dyes EM Elastic properties Elasticity Electron Microscopy Electron Transport Chain Enterococcus faecium Enzymes Epipolythiodioxopiperazine Epithelial barrier Epithelial models Epithelial permeability Estradiol Excipients Extracellular matrix protein FTIR FcRn pathway Focal adhesions Folate ligands Food Microbiology Foodborne Diseases Fructose GABA Modulators GC-MS GCM GHB concentration GSH Gamma-hydroxybutyrate Gene delivery Gene therapy Glass Gliotoxin Glutamate receptors Glutathione Glycosides Good correlations Guinea pig ileum H202 H460 HU 210 Heart High-resolution imaging Human keratinocytes Humans Huntington Disease Huntington chorea Hydrocortisone Hydrogen bonds Hydrogen chloride Hydrogen peroxide Hydroxybutyrate IgG Image reconstruction Imaging systems Immumnoelectron microscopy Immunocytochemistry Immunofluorescence staining In situ crystallization Injection Injection port Injections, Intravenous Integrins Interfacial interaction Ischaemia Ischemia Isotopes Keratinocytes Kidney Kinetics L-buthionine sulfoximine Ligand density Linear elasticity Liposomes Liquid crystals Listeria Liver MPP+ MPTP MRS Macromolecular permeability Magnetic field strength Mammalia Marijuana Smoking Mass spectrometry Mechanics Medical applications Medicinal chemistr Metabolism Metal free porphyrin Metastable polymorphs Methane Microdose Microdosing Middle Aged Mitochondria Molecular Structure Mucoadhesion Mucosal delivery Mucosal protein delivery Multicomponent crystals Multiplex Polymerase Chain Reaction N omega-nitro-L-arginine NMR NMR Spectroscopy NMR spectroscopy NOS NRPS Nanomedicines Nanoparticle transport Nanoparticles Nanotechnology Nasal drug delivery Nitric Oxide Synthase Nitroparaffins Nootropic Agents Novel applications Nuclear physics Nucleation Nucleosides Nucleotides Nystagmus, Pathologic Ocular Motility Disorders Oligonucleotides Oligoribonucleotides Operating ranges Optimisation Optimization Oxidative Phosphorylation Oxidative Stress PEG PEG-g-chitosan PEGylated nanomedicines PEGylation Parkinson's disease Particle morphology, Crystal engineering Permeability enhancement Permeation enhancer Permeation enhancers Pharmaceutical Preparations Pharmacokinetics Pharmacy Phase 0 Phase Transition Phase transitions, Reaction kinetics Phosphodiester Phosphodiesters Polymorphic modifications, Carboxylic acids Polymorphism Polymorphs Polystyrene nanoparticles Port Proteins Proton Qualitative analysis RNA Rat Redox Reduced toxicity Reperfusion Reperfusion injury Respiratory chain Reverse Transcriptase Polymerase Chain Reaction Ribonucleosides SB366791 SPAP reporter gene Saccades Scattering matrices Scattering parameters Sensors Shear deformation Shear rates, Adhesion Silylation Skeletal Muscle Solid-phase synthesis Solubility Solvents Sporidesmin A} Structure elucidation, Organic compounds Sulfoxides, Alliaceae Sulfur compounds, Polymorphs, Powders, solvent Supersensitivity Supramolecular chemistry, Drug products, er 34122 Surface modification Surface plasmon excitation Surface plasmon resonance, Plasmons, vinculin, article Surfactants Suspensions Synaptosomal Synaptosomes Synchrotrons Synthesis TASTPM TBC TEER THC TRPV1 Technology, Pharmaceutical Temperature Temperature measurement, Thermochromic polymeric films, Plastic films Tetradecylmaltoside Tight junction modulation Tight junctions Time Factors Tissue engineering Tissue engineering, Cells Toxicity Toxicology Transepithelial electrical resistance Treatment Outcome Tridecylmaltoside Tumors Ultrasensitive drug analysis, Carbon, Animalia Uptake inhibition Van de Graaff accelerators, Accelerator mass spectrometry Vanilloid Vanilloids Veterinary Antivirals Virology Water Watercress Wide-field, Cell adhesion X ray analysis X ray diffraction, 2-Propanol X ray powder diffraction X ray powder diffraction, Benzamide X-ray diffraction Xanthone abasic site acetyl-L-carnitine acute liver failure adult alliin lyase alpha 1 adrenergic receptor blocking agent amyloid precursor protein anandamide anticancer antidepressants antiestrogen apoptosis area under the curve article atenolol bacteriocin beta-adrenoceptors bioengineering bipolar disorder bmjindex brain brain slices brain stem caffeine cancer cannabinoid cannabis, adult capsazepine carbamazepine carbon 14 carbon tetrachloride case report celiprolol cell adhesion cell interaction cell surface cellular distribution cellular stress cerebral ischaemia cerebral ischemia chemical modification chemical phenomena chemical reaction chemical structure chemistry chitosan chlorimipramine clarithromycin clinical article clinical trial clomipramine complexexs computer simulation conference paper controlled clinical trial controlled study cornea reflex cross linking crystal crystal structure crystallization crystallography culture technique curcumin cyclic-AMP cysteine cytochrome P450 3A4 data analysis databases development diagnostic and therapeutic imaging diazepam differential scanning calorimetry digoxin diphenhydramine disease course dopamine dopamine receptor dose calculation dose response dose time effect relation drug drug absorption drug activity drug and gene delivery drug bioavailability drug blood level drug classification drug clearance drug cost drug delivery system drug derivative drug distribution drug effect drug efficacy drug half life drug impurity drug mechanism drug metabolism drug microdose drug monitoring drug penetration drug research drug safety drug solubility drug stability drug structure eNOS electron transport chain element enalapril endocannabinoid energy transfer enterocin enzymes erythromycin excitotoxicity eye movement control factual fast GC-MS screening female fentanyl fermentation fexofenadine flow rate fluconazole folic acid food food and drug administration forensic drug analysis fosdevirine free radicals garlic gene expression gene transcription genetics glibenclamide glioma glutamate glutamate toxicity glutamic acid, article glycoprotein P glycosides griseofulvin half life time high performance liquid chromatography human human tissue hydration hydrocortisone, article hydrogen bond hydrogen peroxide hydrolysis imaging system immobilized lipas immunocytochemistry immunofluorescence isobutanol kainate keratinocyte kinetics legal highs lipoxygenase inhibitor liquid chromatography liquid crystal listeriosis lithium liver clearance liver failure losartan lung cancer lyase male manganese [III] tetrakis 4-benzoic acid porphyrin mass spectrometry material coating medical literature metabolism metformin methanol methodology metoprolol microdosing microfluidics microscopy midazolam mitochondria mitochondrial complexes mitochondrial membrane potential molecular interaction molecular model molecular stability monitoring multiple sclerosis necrosis neurodegeneration neuroprotection nicardipine nitromethane nonhuman normal human novel psychoactive substances nucleic acids} nutrition nystagmus oaemailed oligodendrocyte optical density optical reflection oxidative stress pH effects paracetamol particle size patient participation peer review peroxynitrite pharmacy phase transition phenazone phenobarbital phospholipid photon correlation spectroscopy physical chemistry piracetam plasma concentration-time curve poly(vinyl alcohol)-cryogel carrier} positron emission tomography precipitation presenilin-1 priority journal priority journal, Administration, Oral propafenone prostaglandin synthase inhibitor protein polymorphism psychiatry quinidine raltegravir reactor redox homeostasis redox state redox-dependent refraction index resiniferatoxin respiratory chain complexes resveratrol reverse transcription polymerase chain reaction review review, Allium review, Biological Availability saccadic eye movement scanning electron microscopy schizophrenia simulation smoking solid phase extraction solid state solvation solvent solvent effect solvent, chemical engineering spectral editing sub-classification sulfathiazole, aqueous solution sulfathiazole, crystal sulfoxide, catalysis sumatriptan superoxide dismutase surface property suspension tandem mass spectrometry tegmentum, Eye Movements telmisartan temperature sensitivity tenofovir thermodynamics tolbutamide toxicology transmission electron microscopy transmucosal tricyclic tubercidin unclassified drug unclassified drug, area under the curve unclassified drug, article unclassified drug, bacterial strain unindexed drug verapamil virulence, Anti-Bacterial Agents vitagenes voluntary movement, Adult volunteer warfarin water, article widefield surface plasmon resonance microscopy zeta potential, Anti-Inflammatory Agents zidovudine, area under the curve zk 253, adult zk 253, area under the curve
Number of items at this level: 811.

(E) - capsaicin

Athanasiou, Andriani and Smith, Paul A. and Vakilpour, Sara and Kumaran, Nethia M. and Turner, Amy E. and Bagiokou, Dimitra and Layfield, Robert and Ray, David E. and Westwell, Andrew D. and Alexander, Stephen P. H. and Kendall, David A. and Lobo, Dileep N. and Watson, Susan A. and Lophatanon, Artitaya and Muir, Kenneth A. and Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

1-methyl-4-phenylpyridinium

Bates, T. E. and Heales, S. J. and Davies, S. E. and Boakye, P. and Clark, J. B. (1994) Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. Journal of neurochemistry, 63 (2). pp. 640-648. ISSN 0022-3042

1H

Bates, Timothy E. and Williams, Stephen R. and Kauppinen, Risto A. and Gadian, David G. (1989) Observation of cerebral metabolites in an animal model of acute liver failure in vivo: a 1H and 31P nuclear magnetic resonance study. Journal of neurochemistry, 53 (1). pp. 102-10. ISSN 0022-3042

Brooks, K. J. and Kauppinen, R. A. and Williams, S. R. and Bachelard, H. S. and Bates, T. E. and Gadian, D. G. (1989) Ammonia causes a drop in intracellular pH in metabolizing cortical brain slices. A [31P]- and [1H]nuclear magnetic resonance study. Neuroscience, 33 (1). pp. 185-192. ISSN 0306-4522

Gadian, D. G. and Bates, T. E. and Williams, S. R. and Bell, J. D. and Austin, S. J. and Connelly, A. (1991) Approaches to editing, assignment and interpretation of proton spectra. NMR in biomedicine, 4 (2). pp. 85-89. ISSN 0952-3480

2 amino 4 nitrophenol

Blagden, Nicholas and Cross, Wendy I. and Davey, Roger J. and Broderick, Mairead and Pritchard, Robin G. and Roberts, Ronald J. and Rowe, Raymond C. (2001) Can crystal structure prediction be used as part of an integrated strategy for ensuring maximum diversity of isolated crystal forms? The case of 2-amino-4-nitrophenol. Physical Chemistry Chemical Physics, 3 (17). pp. 3819-3825. ISSN 1463-9076

2 propanol

Dematos, Luciana L. and Williams, Adrian C. and Booth, Steven W. and Petts, Catherine R. and Taylor, David J. and Blagden, Nicholas (2007) Solvent influences on metastable polymorph lifetimes: real-time interconversions using energy dispersive X-ray diffractometry. Journal of Pharmaceutical Sciences, 96 (5). pp. 1069-1078. ISSN 0022-3549

31P

Bates, Timothy E. and Williams, Stephen R. and Gadian, David G. (1989) Phosphodiesters in the liver: the effect of field strength on the 31P signal. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 12 (1). pp. 145-150. ISSN 0740-3194

Bates, Timothy E. and Williams, Stephen R. and Kauppinen, Risto A. and Gadian, David G. (1989) Observation of cerebral metabolites in an animal model of acute liver failure in vivo: a 1H and 31P nuclear magnetic resonance study. Journal of neurochemistry, 53 (1). pp. 102-10. ISSN 0022-3042

Brooks, K. J. and Kauppinen, R. A. and Williams, S. R. and Bachelard, H. S. and Bates, T. E. and Gadian, D. G. (1989) Ammonia causes a drop in intracellular pH in metabolizing cortical brain slices. A [31P]- and [1H]nuclear magnetic resonance study. Neuroscience, 33 (1). pp. 185-192. ISSN 0306-4522

Murphy, Elizabeth J. and Bates, Timothy E. and Williams, Stephen R. and Watson, Tracey and Brindle, Kevin M. and Rajagopalan, Bheeshma and Radda, George K. (1992) Endoplasmic reticulum: the major contributor to the PDE peak in hepatic 31P-NMR spectra at low magnetic field strengths. Biochimica et biophysica acta: biomembranes, 1111 (1). pp. 51-58. ISSN 0005-2736

4 nitrophenol

Blagden, Nicholas and Cross, Wendy I. and Davey, Roger J. and Broderick, Mairead and Pritchard, Robin G. and Roberts, Ronald J. and Rowe, Raymond C. (2001) Can crystal structure prediction be used as part of an integrated strategy for ensuring maximum diversity of isolated crystal forms? The case of 2-amino-4-nitrophenol. Physical Chemistry Chemical Physics, 3 (17). pp. 3819-3825. ISSN 1463-9076

5-IAI

Elie, Mathieu P. and Elie, Leonie E. and Baron, Mark G. (2013) Keeping pace with NPS releases: fast GC-MS screening of legal high products. Drug Testing and Analysis, 5 (5). pp. 281-290. ISSN 1942-7603

AEA

Athanasiou, Andriani and Clarke, Anna B. and Turner, Amy E. and Kumaran, Nethia M. and Vakilpour, Sara and Smith, Paul A. and Bagiokou, Dimitra and Bradshaw, Tracey D. and Westwell, Andrew D. and Fang, Lin and Lobo, Dileep N. and Constantinescu, Cris S. and Calabrese, Vittorio and Loesch, Andrzej and Alexander, Stephen P. H. and Clothier, Richard H. and Kendall, David A. and Bates, Timothy E. (2007) Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications, 364 (1). pp. 131-137. ISSN 0006-291x

AFM

Soon, C. F. and Omar, W. I. W. and Berends, R. F. and Nayan, N. and Basri, H. and Tee, K. S. and Youseffi, M. and Blagden, Nicholas and Denyer, M. C. T. (2014) Biophysical characteristics of cells cultured on cholesteryl ester liquid crystals. Micron, 56 . pp. 73-79. ISSN 0968-4328

AMPA

Rosin, Claudia and Bates, Timothy E. and Skaper, Stephen D. (2004) Excitatory amino acid induced oligodendrocyte cell death in vitro: receptor-dependent and -independent mechanisms. Journal of Neurochemistry, 90 (5). pp. 1173-1185. ISSN 0022-3042

ATP

Allen, Kathryn L. and Almeida, Angeles and Bates, Timothy E. and Clark, John B. (1995) Changes of respiratory chain activity in mitochondrial and synaptosomal fractions isolated from the gerbil brain after graded ischaemia. Journal of neurochemistry, 64 (5). pp. 2222-2229. ISSN 0022-3042

Bates, T. E. and Heales, S. J. and Davies, S. E. and Boakye, P. and Clark, J. B. (1994) Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. Journal of neurochemistry, 63 (2). pp. 640-648. ISSN 0022-3042

Absorption enhancement

Casettari, Luca and Vllasaliu, Driton and Castagnino, Enzo and Stolnik, Snjezana and Howdle, Steven and Illum, Lisbeth (2012) PEGylated chitosan derivatives: synthesis, characterizations and pharmaceutical applications. Progress in Polymer Science, 37 (5). pp. 659-685. ISSN 0079-6700

Vllasaliu, Driton and Casettari, Luca and Fowler, Robyn and Exposito-Harris, Ruth and Garnett, Martin and Illum, Lisbeth and Stolnik, Snow (2012) Absorption-promoting effects of chitosan in airway and intestinal cell lines: a comparative study. International Journal of Pharmaceutics, 430 (1-2). pp. 151-160. ISSN 0378-5173

Accelerator mass spectrometry

Lappin, G. and Boyce, M. J. and Matzow, T. and Lociuro, S. and Seymour, M. and Warrington, S. J. (2013) A microdose study of 14C-AR-709 in healthy men: pharmacokinetics, absolute bioavailability and concentrations in key compartments of the lung. European Journal of Clinical Pharmacology, 69 (9). pp. 1673-1682. ISSN 0031-6970

Acid condition

Elie, Mathieu Pierre and Baron, Mark G. and Birkett, Jason W. (2012) Injection port silylation of γ-hydroxybutyrate and trans-hydroxycrotonic acid: Conditions optimisation and characterisation of the di-tert-butyldimethylsilyl derivatives by GC-MS. Analyst, 137 (1). p. 255. ISSN 0003-2654

Acid-base complexation reaction

Baron, M. G. and Narayanaswamy, R. and Thorpe, S. C. (1996) Hydrophobic membrane sensors for the optical determination of hydrogen chloride gas. Sensors and Actuators, B: Chemical, 34 (1-3). pp. 511-515. ISSN 0925-4005

Adolescent

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Adult

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Aged

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Aged, 80 and over

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Alkylation

Belokon, Yuri N. and Kochetkov, Konstantin A. and Churkina, Tatiana D. and Ikonnikov, Nikolai S. and Chesnokov, Alexey A. and Larionov, Oleg V. and Singh, Ishwar and Parmar, Virinder S. and Vyskocil, Stepan and Kagan, Henri B. (2000) Asymmetric PTC C-alkylation catalyzed by chiral derivatives of tartaric acid and aminophenols. Synthesis of (R)- and (S)-alpha-methyl amino acids. Journal of Organic Chemistry, 65 (21). pp. 7041-7048. ISSN 0022-3263

Alkylglycosides

Vllasaliu, Driton and Shubber, Saif and Fowler, Robyn and Garnett, Martin and Alexander, Cameron and Stolnik, Snow (2013) Epithelial toxicity of alkylglycoside surfactants. Journal of Pharmaceutical Sciences, 102 (1). pp. 114-125. ISSN 0975-1459

Alkynes

Singh, Ishwar and Freeman, Colin and Heaney, Frances (2011) Efficient synthesis of DNA conjugates by strain-promoted azide-cyclooctyne cycloaddition in the solid phase. European Journal of Organic Chemistry (33). pp. 6739-6746. ISSN 1434-193X

Allium

Rose, Peter and Whiteman, Matt and Moore, Philip K. and Yi, Zhun Zhu (2005) Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents. Natural Product Reports, 22 (3). pp. 351-368. ISSN 0265-0568

Allium cepa

Rose, Peter and Whiteman, Matt and Moore, Philip K. and Yi, Zhun Zhu (2005) Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents. Natural Product Reports, 22 (3). pp. 351-368. ISSN 0265-0568

Allium sativum

Rose, Peter and Whiteman, Matt and Moore, Philip K. and Yi, Zhun Zhu (2005) Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents. Natural Product Reports, 22 (3). pp. 351-368. ISSN 0265-0568

Alzheimer's

Mancuso, Cesare and Bates, Timothy E. and Butterfield, D. Allan and Calafato, Stella and Cornelius, Carolin and De Lorenzo, Antonino and Dinkova Kostova, Albena T. and Calabrese, Vittorio (2007) Natural antioxidants in Alzheimer's disease. Expert Opinion on Investigational Drugs, 16 (12). pp. 1921-1931. ISSN 1354-3784

Pardon, Marie-Christine and Sarmad, Sarir and Rattray, Ivan and Bates, Timothy E. and Scullion, Gillian A. and Marsden, Charles A. and Barrett, David A. and Lowe, James and Kendall, David A. (2009) Repeated novel cage exposure-induced improvement of early Alzheimer's-like cognitive and amyloid changes in TASTPM mice is unrelated to changes in brain endocannabinoids levels. Neurobiology of Aging, 30 (7). pp. 1099-1113. ISSN 0197-4580

Amino acid

Casettari, Luca and Vllasaliu, Driton and Lam, Jenny K. W. and Soliman, Mahmoud and Illum, Lisbeth (2012) Biomedical applications of amino acid-modified chitosans: a review. Biomaterials, 33 (30). pp. 7565-7583. ISSN 0142-9612

Ammonia

Brooks, K. J. and Kauppinen, R. A. and Williams, S. R. and Bachelard, H. S. and Bates, T. E. and Gadian, D. G. (1989) Ammonia causes a drop in intracellular pH in metabolizing cortical brain slices. A [31P]- and [1H]nuclear magnetic resonance study. Neuroscience, 33 (1). pp. 185-192. ISSN 0306-4522

Antibiosis

Williams, David R. and Chanos, P. (2012) Application of anti-listerial bacteriocins: monitoring enterocin expression by multiplex relative reverse transcription-PCR. Biochemical Society Transactions, 40 (6). pp. 1544-1548. ISSN 0300-5127

Anticoagulants

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Antioxidants

Mancuso, Cesare and Bates, Timothy E. and Butterfield, D. Allan and Calafato, Stella and Cornelius, Carolin and De Lorenzo, Antonino and Dinkova Kostova, Albena T. and Calabrese, Vittorio (2007) Natural antioxidants in Alzheimer's disease. Expert Opinion on Investigational Drugs, 16 (12). pp. 1921-1931. ISSN 1354-3784

Area Under Curve

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Artificial organs

Soon, C. F. and Youseffi, M. and Blagden, N. and Lobo, S. B. and Javid, F. A. and Denyer, M. C. T. (2009) Interactions of cells with elastic cholesteryl liquid crystals. In: World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany.

Aspergillus fumigatu

Davis, Carol and Gordon, Natasha and Murphy, Sinead and Singh, Ishwar and Kavanagh, Kevin and Carberry, Stephen and Doyle, Sean (2011) Single-pot derivatisation strategy for enhanced gliotoxin detection by HPLC and MALDI-ToF mass spectrometry. Analytical and Bioanalytical Chemistry, 401 (8). pp. 2519-2529. ISSN 1618-2642

Azides

Singh, Ishwar and Freeman, Colin and Heaney, Frances (2011) Efficient synthesis of DNA conjugates by strain-promoted azide-cyclooctyne cycloaddition in the solid phase. European Journal of Organic Chemistry (33). pp. 6739-6746. ISSN 1434-193X

BSO

Heales, S. J. and Davies, S. E. and Bates, T. E. and Clark, J. B. (1995) Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration. Neurochemical research, 20 (1). pp. 31-38. ISSN 0364-3190

Bacteriocins

Williams, David R. and Chanos, P. (2012) Application of anti-listerial bacteriocins: monitoring enterocin expression by multiplex relative reverse transcription-PCR. Biochemical Society Transactions, 40 (6). pp. 1544-1548. ISSN 0300-5127

Basement membrane

Vllasaliu, Driton and Falcone, Franco H. and Stolnik, Snjezana and Garnett, Martin (2014) Basement membrane influences intestinal epithelial cell growth and presents a barrier to the movement of macromolecules. Experimental Cell Research, 323 (1). pp. 218-231. ISSN 0014-4827

Batch Cell Culture Techniques

Williams, David R. and Chanos, P. (2012) Application of anti-listerial bacteriocins: monitoring enterocin expression by multiplex relative reverse transcription-PCR. Biochemical Society Transactions, 40 (6). pp. 1544-1548. ISSN 0300-5127

Biocompatibility

Vllasaliu, Driton and Shubber, Saif and Fowler, Robyn and Garnett, Martin and Alexander, Cameron and Stolnik, Snow (2013) Epithelial toxicity of alkylglycoside surfactants. Journal of Pharmaceutical Sciences, 102 (1). pp. 114-125. ISSN 0975-1459

Bioconjugation}

Singh, Ishwar and Freeman, Colin and Heaney, Frances (2011) Efficient synthesis of DNA conjugates by strain-promoted azide-cyclooctyne cycloaddition in the solid phase. European Journal of Organic Chemistry (33). pp. 6739-6746. ISSN 1434-193X

Biological Markers

Golding, C. V. P. and Danchaivijitr, C. and Hodgson, T. L. and Tabrizi, S. J. and Kennard, C. (2006) Identification of an oculomotor biomarker of preclinical Huntington disease. Neurology, 67 (3). pp. 485-487. ISSN 0028-3878

Biomarkers

Lappin, Graham and Garner, R. Colin (2004) Current perspectives of 14C-isotope measurement in biomedical accelerator mass spectrometry. Analytical and Bioanalytical Chemistry, 378 (2). pp. 356-364. ISSN 1618-2642

Biosynthesis

Davis, Carol and Carberry, Stephen and Schrettl, Markus and Singh, Ishwar and Stephens, John C. and Barry, Sarah M. and Kavanagh, Kevin and Challis, Gregory L. and Brougham, Dermot and Doyle, Sean (2011) The role of glutathione S-Transferase GliG in gliotoxin biosynthesis in Aspergillus fumigatus. Chemistry and Biology, 18 (4). pp. 542-552. ISSN 1074-5521

Brain

Allen, Kathryn L. and Almeida, Angeles and Bates, Timothy E. and Clark, John B. (1995) Changes of respiratory chain activity in mitochondrial and synaptosomal fractions isolated from the gerbil brain after graded ischaemia. Journal of neurochemistry, 64 (5). pp. 2222-2229. ISSN 0022-3042

Bates, T. E and Loesch, A. and Burnstock, G. and Clark, J. B. (1995) Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver. Biochemical and biophysical research communications, 213 (3). pp. 896-900. ISSN 0006-291X

Bates, T. E. and Heales, S. J. and Davies, S. E. and Boakye, P. and Clark, J. B. (1994) Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. Journal of neurochemistry, 63 (2). pp. 640-648. ISSN 0022-3042

Gadian, D. G. and Bates, T. E. and Williams, S. R. and Bell, J. D. and Austin, S. J. and Connelly, A. (1991) Approaches to editing, assignment and interpretation of proton spectra. NMR in biomedicine, 4 (2). pp. 85-89. ISSN 0952-3480

Heales, S. J. and Davies, S. E. and Bates, T. E. and Clark, J. B. (1995) Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration. Neurochemical research, 20 (1). pp. 31-38. ISSN 0364-3190

Brain Slices

Brooks, Keith J. and Hargreaves, Iain P. and Bates, Timothy E. (2008) Protection of respiratory chain enzymes from ischaemic damage in adult rat brain slices. Neurochemical research, 33 (9). pp. 1711-1716. ISSN 0364-3190

Bronchial alveolar lavage

Lappin, G. and Boyce, M. J. and Matzow, T. and Lociuro, S. and Seymour, M. and Warrington, S. J. (2013) A microdose study of 14C-AR-709 in healthy men: pharmacokinetics, absolute bioavailability and concentrations in key compartments of the lung. European Journal of Clinical Pharmacology, 69 (9). pp. 1673-1682. ISSN 0031-6970

Butanols

Dematos, Luciana L. and Williams, Adrian C. and Booth, Steven W. and Petts, Catherine R. and Taylor, David J. and Blagden, Nicholas (2007) Solvent influences on metastable polymorph lifetimes: real-time interconversions using energy dispersive X-ray diffractometry. Journal of Pharmaceutical Sciences, 96 (5). pp. 1069-1078. ISSN 0022-3549

Byproducts

Blagden, Nicholas (2001) Crystal engineering of polymorph appearance: the case of sulphathiazole. Powder Technology, 121 (1). pp. 46-52. ISSN 0032-5910

CHO cells

Abdel-Razaq, W. and Bates, T. E. and Kendall, D. A. (2007) The effects of antidepressants on cyclic AMP-response element-driven gene transcription in a model cell system. Biochemical Pharmacology, 73 (12). pp. 1995-2003. ISSN 0006-2952

Caco-2

Vllasaliu, Driton and Casettari, Luca and Fowler, Robyn and Exposito-Harris, Ruth and Garnett, Martin and Illum, Lisbeth and Stolnik, Snow (2012) Absorption-promoting effects of chitosan in airway and intestinal cell lines: a comparative study. International Journal of Pharmaceutics, 430 (1-2). pp. 151-160. ISSN 0378-5173

Vllasaliu, Driton and Fowler, Robyn and Garnett, Martin and Eaton , Mike and Stolnik, Snow (2011) Barrier characteristics of epithelial cultures modelling the airway and intestinal mucosa: a comparison. Biochemical and Biophysical Research Communications, 415 (4). pp. 579-585. ISSN 0006-291X

Vllasaliu, Driton and Shubber, Saif and Garnett, Martin and Alexander, Cameron and Eaton, Mike and Stolnik, Snow (2012) Evaluation of calcium depletion as a strategy for enhancement of mucosal absorption of macromolecules. Biochemical and Biophysical Research Communications, 418 (1). pp. 128-133. ISSN 0006-291X

Caco-2 cells

Garnett, Martin and Vllasaliu, Driton and Stolnik, Snow and Falcone, Franco (2014) Drug delivery: epithelial cell models for drug transport and toxicology studies. The Biochemist, 36 (3). p. 8. ISSN 0954-982X

Calcium depletion

Vllasaliu, Driton and Shubber, Saif and Garnett, Martin and Alexander, Cameron and Eaton, Mike and Stolnik, Snow (2012) Evaluation of calcium depletion as a strategy for enhancement of mucosal absorption of macromolecules. Biochemical and Biophysical Research Communications, 418 (1). pp. 128-133. ISSN 0006-291X

Calu-3

Vllasaliu, Driton and Casettari, Luca and Fowler, Robyn and Exposito-Harris, Ruth and Garnett, Martin and Illum, Lisbeth and Stolnik, Snow (2012) Absorption-promoting effects of chitosan in airway and intestinal cell lines: a comparative study. International Journal of Pharmaceutics, 430 (1-2). pp. 151-160. ISSN 0378-5173

Vllasaliu, Driton and Exposito-Harris, Ruth and Heras, Angeles and Casettari, Luca and Garnett, Martin and Illum, Lisbeth and Stolnik, Snow (2010) Tight junction modulation by chitosan nanoparticles: comparison with chitosan solution. International Journal of Pharmaceutics, 400 (1-2). pp. 183-193. ISSN 0378-5173

Vllasaliu, Driton and Fowler, Robyn and Garnett, Martin and Eaton , Mike and Stolnik, Snow (2011) Barrier characteristics of epithelial cultures modelling the airway and intestinal mucosa: a comparison. Biochemical and Biophysical Research Communications, 415 (4). pp. 579-585. ISSN 0006-291X

Vllasaliu, Driton and Shubber, Saif and Garnett, Martin and Alexander, Cameron and Eaton, Mike and Stolnik, Snow (2012) Evaluation of calcium depletion as a strategy for enhancement of mucosal absorption of macromolecules. Biochemical and Biophysical Research Communications, 418 (1). pp. 128-133. ISSN 0006-291X

Calu-3 cells

Vllasaliu, Driton and Shubber, Saif and Fowler, Robyn and Garnett, Martin and Alexander, Cameron and Stolnik, Snow (2013) Epithelial toxicity of alkylglycoside surfactants. Journal of Pharmaceutical Sciences, 102 (1). pp. 114-125. ISSN 0975-1459

Carbon Radioisotopes

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Carbon-Sulfur Lyases

Rose, Peter and Whiteman, Matt and Moore, Philip K. and Yi, Zhun Zhu (2005) Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents. Natural Product Reports, 22 (3). pp. 351-368. ISSN 0265-0568

Cardiac

Broadley, K. J. and Williams, R. G. and Hawthorn, M. H. and Grassby, Paul (1984) Mechanisms of cardiac supersensitivity to sympathomimetic amines. Methods and Findings in Experimental and Clinical Pharmacology, 6 (4). pp. 179-186. ISSN 0379-0355

Catalysis

Rose, Peter and Whiteman, Matt and Moore, Philip K. and Yi, Zhun Zhu (2005) Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents. Natural Product Reports, 22 (3). pp. 351-368. ISSN 0265-0568

Cell adhesion

Soon, C. F. and Omar, W. I. W. and Berends, R. F. and Nayan, N. and Basri, H. and Tee, K. S. and Youseffi, M. and Blagden, Nicholas and Denyer, M. C. T. (2014) Biophysical characteristics of cells cultured on cholesteryl ester liquid crystals. Micron, 56 . pp. 73-79. ISSN 0968-4328

Soon, C. F. and Youseffi, M. and Blagden, N. and Lobo, S. B. and Javid, F. A. and Denyer, M. C. T. (2009) Interactions of cells with elastic cholesteryl liquid crystals. In: World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany.

Cell contraction

Soon, C. F. and Youseffi, M. and Blagden, N. and Lobo, S. B. and Javid, F. A. and Denyer, M. C. T. (2009) Interactions of cells with elastic cholesteryl liquid crystals. In: World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany.

Cell mechanic

Soon, C. F. and Youseffi, M. and Blagden, N. and Lobo, S. B. and Javid, F. A. and Denyer, M. C. T. (2009) Interactions of cells with elastic cholesteryl liquid crystals. In: World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany.

Cell monolayers

Casettari, Luca and Vllasaliu, Driton and Mantovani, Guiseppe and Howdle, Steven M. and Stolnik, Snow and Illum, Lisbeth (2010) Effect of PEGylation on the toxicity and permeability enhancement of chitosan. Biomacromolecules, 11 (11). pp. 2854-2865. ISSN 1525-7797

Cell surface morphology

Soon, C. F. and Omar, W. I. W. and Berends, R. F. and Nayan, N. and Basri, H. and Tee, K. S. and Youseffi, M. and Blagden, Nicholas and Denyer, M. C. T. (2014) Biophysical characteristics of cells cultured on cholesteryl ester liquid crystals. Micron, 56 . pp. 73-79. ISSN 0968-4328

Cell surface roughness

Soon, C. F. and Omar, W. I. W. and Berends, R. F. and Nayan, N. and Basri, H. and Tee, K. S. and Youseffi, M. and Blagden, Nicholas and Denyer, M. C. T. (2014) Biophysical characteristics of cells cultured on cholesteryl ester liquid crystals. Micron, 56 . pp. 73-79. ISSN 0968-4328

Cells

Soon, Chin Phong and Khaghani, Seyed Ali and Youseffi, Mansour and Nayan, Nafarizal and Saim, Hashim and Britland, Stephen and Blagden, Nicholas and Denyer, Morgan Clive Thomas (2013) Interfacial study of cell adhesion to liquid crystals using widefield surface plasmon resonance microscopy. Colloids and Surfaces B: Biointerfaces, 110 . pp. 156-162. ISSN 0927-7765

Cells adhesion

Soon, C. F. and Youseffi, M. and Blagden, N. and Lobo, S. B. and Javid, F. A. and Denyer, M. C. T. (2009) Interactions of cells with elastic cholesteryl liquid crystals. In: World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany.

Cellular stress response

Calabrese, Vittorio and Cornelius, Carolin and Mancuso, Cesare and Pennisi, Giovanni and Calafato, Stella and Bellia, Francesco and Bates, Timothy E. and Giuffrida Stella, Anna Maria and Schapira, Tony and Dinkova Kostova, Albena T. and Rizzarelli, Enrico (2008) Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity. Neurochemical Research, 33 (12). pp. 2444-2471. ISSN 0364-3190

Cellular uptake

Moradi, Emilia and Vllasaliu, Driton and Garnett, Martin and Falcone, Franco and Stolnik, Snow (2012) Ligand density and clustering effects on endocytosis of folate modified nanoparticles. RSC Advances, 2 (7). pp. 3025-3033. ISSN 2046-2069

Characterisation

Elie, Mathieu Pierre and Baron, Mark G. and Birkett, Jason W. (2012) Injection port silylation of γ-hydroxybutyrate and trans-hydroxycrotonic acid: Conditions optimisation and characterisation of the di-tert-butyldimethylsilyl derivatives by GC-MS. Analyst, 137 (1). p. 255. ISSN 0003-2654

Charge transfer

Seaton, Colin C. and Blagden, Nicholas and Munshi, Tasnim and Scowen, Ian J. (2013) Creation of ternary multicomponent crystals by exploitation of charge-transfer interactions. Chemistry - A European Journal, 19 (32). pp. 10663-10671. ISSN 0947-6539

Chemical gas sensor

Baron, M. G. and Narayanaswamy, R. and Thorpe, S. C. (1996) Hydrophobic membrane sensors for the optical determination of hydrogen chloride gas. Sensors and Actuators, B: Chemical, 34 (1-3). pp. 511-515. ISSN 0925-4005

Chemistry

Blagden, Nicholas and Davey, R. (1999) Polymorphs take shape. Chemistry in Britain, 35 (3). pp. 44-45. ISSN 0009-3106

Errington, W. and Parmar, V. S. and Singh, A. and Singh, I. (2001) 7-acetoxy-4-(1-chloroethyl)coumarin. Acta Crystallographica Section E - Structure Reports Online, 57 (10). O939-O940. ISSN 1600-5368

Kumar, Ajay and Husain, Mofazzal and Prasad, Ashok K. and Singh, Iswar and Vats, Archana and Sharma, Nawal K. and Sharma, Sunil K. and Gupta, Rajinder K. and Olsen, Carl E. and Bracke, Marc E. and Gross, Richard A. and Parmar, Virinder S. (2003) Synthesis of novel heterocyclic compounds: routes to pyrazolyl 1,2,3-triazoles and their biological activity evaluation. Indian Journal of Chemistry : Section B, Oganic Chemistry including Medicinal Chemistry, 42 (8). pp. 1950-1957. ISSN 0376-4699

Singh, Ishwar and Seitz, Oliver (2006) Diastereoselective synthesis of beta-aryl-C-nucleosides from 1,2-anhydrosugars. Organic Letters, 8 (19). pp. 4319-4322. ISSN 1523-7060

Singh, Ishwar and Zarafshani, Zoya and Heaney, Frances and Lutz, Jean-Francois (2011) Orthogonal modification of polymer chain-ends via sequential nitrile oxide-alkyne and azide-alkyne Huisgen cycloadditions. Polymer Chemistry, 2 (2). pp. 372-375. ISSN 1759-9954

Singh, Ishwar and Zarafshani, Zoya and Lutz, Jean-Francois and Heaney, Frances (2009) Metal-Free "Click'' chemistry: efficient polymer modification via 1,3-dipolar cycloaddition of nitrile oxides and alkynes. Macromolecules, 42 (15). pp. 5411-5413. ISSN 0024-9297

Wendeln, Christian and Singh, Ishwar and Rinnen, Stefan and Schulz, Christian and Arlinghaus, Heinrich F. and Burley, Glenn A. and Ravoo, Bart Jan (2012) Orthogonal, metal-free surface modification by strain-promoted azide-alkyne and nitrile oxide-alkene/alkyne cycloadditions. Chemical Science, 3 (8). pp. 2479-2484. ISSN 2041-6520

Chemistry, Pharmaceutical

Ali, Hany S. M. and York, Peter and Blagden, Nicholas (2009) Preparation of hydrocortisone nanosuspension through a bottom-up nanoprecipitation technique using microfluidic reactors. International Journal of Pharmaceutics, 375 (1-2). pp. 107-113. ISSN 0378-5173

Blagden, N. and de Matas, M. and Gavan, P.T. and York, P. (2007) Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Advanced Drug Delivery Reviews, 59 (7). pp. 617-630. ISSN 0169-409X

Dematos, Luciana L. and Williams, Adrian C. and Booth, Steven W. and Petts, Catherine R. and Taylor, David J. and Blagden, Nicholas (2007) Solvent influences on metastable polymorph lifetimes: real-time interconversions using energy dispersive X-ray diffractometry. Journal of Pharmaceutical Sciences, 96 (5). pp. 1069-1078. ISSN 0022-3549

Chitosan

Casettari, Luca and Vllasaliu, Driton and Castagnino, Enzo and Stolnik, Snjezana and Howdle, Steven and Illum, Lisbeth (2012) PEGylated chitosan derivatives: synthesis, characterizations and pharmaceutical applications. Progress in Polymer Science, 37 (5). pp. 659-685. ISSN 0079-6700

Casettari, Luca and Vllasaliu, Driton and Lam, Jenny K. W. and Soliman, Mahmoud and Illum, Lisbeth (2012) Biomedical applications of amino acid-modified chitosans: a review. Biomaterials, 33 (30). pp. 7565-7583. ISSN 0142-9612

Vllasaliu, Driton and Casettari, Luca and Fowler, Robyn and Exposito-Harris, Ruth and Garnett, Martin and Illum, Lisbeth and Stolnik, Snow (2012) Absorption-promoting effects of chitosan in airway and intestinal cell lines: a comparative study. International Journal of Pharmaceutics, 430 (1-2). pp. 151-160. ISSN 0378-5173

Vllasaliu, Driton and Exposito-Harris, Ruth and Heras, Angeles and Casettari, Luca and Garnett, Martin and Illum, Lisbeth and Stolnik, Snow (2010) Tight junction modulation by chitosan nanoparticles: comparison with chitosan solution. International Journal of Pharmaceutics, 400 (1-2). pp. 183-193. ISSN 0378-5173

Cholesteryl esters

Soon, C. F. and Omar, W. I. W. and Berends, R. F. and Nayan, N. and Basri, H. and Tee, K. S. and Youseffi, M. and Blagden, Nicholas and Denyer, M. C. T. (2014) Biophysical characteristics of cells cultured on cholesteryl ester liquid crystals. Micron, 56 . pp. 73-79. ISSN 0968-4328

Chromatography, Liquid

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Cinchona pubescens

Rose, Peter and Whiteman, Matt and Moore, Philip K. and Yi, Zhun Zhu (2005) Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents. Natural Product Reports, 22 (3). pp. 351-368. ISSN 0265-0568

Click reaction

Singh, Ishwar and Freeman, Colin and Heaney, Frances (2011) Efficient synthesis of DNA conjugates by strain-promoted azide-cyclooctyne cycloaddition in the solid phase. European Journal of Organic Chemistry (33). pp. 6739-6746. ISSN 1434-193X

Complex I

Bates, T. E. and Heales, S. J. and Davies, S. E. and Boakye, P. and Clark, J. B. (1994) Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. Journal of neurochemistry, 63 (2). pp. 640-648. ISSN 0022-3042

Complexes

Heales, S. J. and Davies, S. E. and Bates, T. E. and Clark, J. B. (1995) Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration. Neurochemical research, 20 (1). pp. 31-38. ISSN 0364-3190

Computer simulation

Davey, R. J. and Blagden, N. and Righini, S. and Alison, H. and Ferrari, E. S. (2002) Nucleation control in solution mediated polymorphic phase transformations: the case of 2,6-dihydroxybenzoic acid. Journal of Physical Chemistry B, 106 (8). pp. 1954-1959. ISSN 1520-6106

Cross-Over Studies

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Crystal engineering

Seaton, Colin C. and Blagden, Nicholas and Munshi, Tasnim and Scowen, Ian J. (2013) Creation of ternary multicomponent crystals by exploitation of charge-transfer interactions. Chemistry - A European Journal, 19 (32). pp. 10663-10671. ISSN 0947-6539

Crystal interfaces

Soon, Chin Phong and Khaghani, Seyed Ali and Youseffi, Mansour and Nayan, Nafarizal and Saim, Hashim and Britland, Stephen and Blagden, Nicholas and Denyer, Morgan Clive Thomas (2013) Interfacial study of cell adhesion to liquid crystals using widefield surface plasmon resonance microscopy. Colloids and Surfaces B: Biointerfaces, 110 . pp. 156-162. ISSN 0927-7765

Crystal structure

David, W. I. F. and Shankland, K. and Pulham, C. R. and Blagden, N. and Davey, R. J. and Song, M. (2005) Polymorphism in benzamide. Angewandte Chemie - International Edition, 44 (43). pp. 7032-7035. ISSN 1433-7851

Crystallization

Blagden, N. and de Matas, M. and Gavan, P.T. and York, P. (2007) Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Advanced Drug Delivery Reviews, 59 (7). pp. 617-630. ISSN 0169-409X

Davey, R. J. and Blagden, N. and Righini, S. and Alison, H. and Ferrari, E. S. (2002) Nucleation control in solution mediated polymorphic phase transformations: the case of 2,6-dihydroxybenzoic acid. Journal of Physical Chemistry B, 106 (8). pp. 1954-1959. ISSN 1520-6106

Crystallography, X-Ray

Dematos, Luciana L. and Williams, Adrian C. and Booth, Steven W. and Petts, Catherine R. and Taylor, David J. and Blagden, Nicholas (2007) Solvent influences on metastable polymorph lifetimes: real-time interconversions using energy dispersive X-ray diffractometry. Journal of Pharmaceutical Sciences, 96 (5). pp. 1069-1078. ISSN 0022-3549

Crystals

Blagden, Nicholas (2001) Crystal engineering of polymorph appearance: the case of sulphathiazole. Powder Technology, 121 (1). pp. 46-52. ISSN 0032-5910

Davey, R. J. and Blagden, N. (1999) Computational approaches to crystal engineering. Journal of Pharmacy and Pharmacology, 51 (SUPPL.). p. 2. ISSN 0022-3573

Soon, C. F. and Youseffi, M. and Blagden, N. and Lobo, S. B. and Javid, F. A. and Denyer, M. C. T. (2009) Interactions of cells with elastic cholesteryl liquid crystals. In: World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany.

Cycloaddition

Singh, Ishwar and Freeman, Colin and Heaney, Frances (2011) Efficient synthesis of DNA conjugates by strain-promoted azide-cyclooctyne cycloaddition in the solid phase. European Journal of Organic Chemistry (33). pp. 6739-6746. ISSN 1434-193X

D2 receptor

Rosin, Claudia and Colombo, Sergio and Calver, Andrew A. and Bates, Timothy E. and Skaper, Stephen D. (2005) Dopamine D2 and D3 receptor agonists limit oligodendrocyte injury caused by glutamate oxidative stress and oxygen/glucose deprivation. Glia, 52 (4). pp. 336-343. ISSN 0894-1491

D3 receptor

Rosin, Claudia and Colombo, Sergio and Calver, Andrew A. and Bates, Timothy E. and Skaper, Stephen D. (2005) Dopamine D2 and D3 receptor agonists limit oligodendrocyte injury caused by glutamate oxidative stress and oxygen/glucose deprivation. Glia, 52 (4). pp. 336-343. ISSN 0894-1491

DNA

Kohler, O. and Jarikote, D. V. and Singh, I. and Parmar, V. S. and Weinhold, E. and Seitz, O. (2005) Forced intercalation as a tool in gene diagnostics and in studying DNA-protein interactions. Pure and Applied Chemistry , 77 (1). pp. 327-338. ISSN 0033-4545

Krpetic, Zeljka and Singh, Ishwar and Su, Wu and Guerrini, Luca and Faulds, Karen and Burley, Glenn A. and Graham, Duncan (2012) Directed assembly of DNA-functionalized gold nanoparticles using pyrrole-imidazole polyamides. Journal of the American Chemical Society, 134 (20). pp. 8356-8359. ISSN 0002-7863

Lappin, Graham and Garner, R. Colin (2004) Current perspectives of 14C-isotope measurement in biomedical accelerator mass spectrometry. Analytical and Bioanalytical Chemistry, 378 (2). pp. 356-364. ISSN 1618-2642

Singh, I. and Beuck, C. and Bhattacharya, A. and Hecker, W. and Parmar, V. S. and Weinhold, E. and Seitz, O. (2004) Abasic site stabilization by aromatic DNA base surrogates: High-affinity binding to a baseflipping DNA-methyltransferase. Pure and Applied Chemistry , 76 (7-8). pp. 1563-1570. ISSN 0033-4545

Singh, Ishwar and Freeman, Colin and Heaney, Frances (2011) Efficient synthesis of DNA conjugates by strain-promoted azide-cyclooctyne cycloaddition in the solid phase. European Journal of Organic Chemistry (33). pp. 6739-6746. ISSN 1434-193X

Singh, Ishwar and Heaney, Frances (2011) Solid phase strain promoted "click'' modification of DNA via [3+2]-nitrile oxide-cyclooctyne cycloadditions. Chemical Communications, 47 (9). pp. 2706-2708. ISSN 1359-7345

Singh, Ishwar and Hecker, Walburga and Prasad, Ashok K. and Parmara, Virinder S. and Seitz, Oliver (2002) Local disruption of DNA-base stacking by bulky base surrogates. Chemical Communications (5). pp. 500-501. ISSN 1359-7345

Singh, Ishwar and Wendeln, Christian and Clark, Alasdair W. and Cooper, Jonathan M. and Ravoo, Bart Jan and Burley, Glenn A. (2013) Sequence-selective detection of double-stranded DNA sequences using pyrrole-imidazole polyamide microarrays. Journal of the American Chemical Society , 135 (9). pp. 3449-3457. ISSN 0002-7863

DNA Virus

Field, Hugh J. and Biswas, Subhajit and Mohammad, Islam T. (2006) Herpesvirus latency and therapy--from a veterinary perspective. Antiviral Research, 71 (2-3). pp. 127-133. ISSN 0166-3542

DNA methylation

Beuck, C and Singh, I. and Bhattacharya, A and Heckler, W and Parmar, VS and Seitz, O and Weinhold, E (2003) Polycyclic aromatic DNA-Base surrogates: high-affinity binding to an adenine-specific base-flipping DNA methyltransferase. Angewandte Chemie International Edition, 42 (33). pp. 3958-3960. ISSN 1433-7851

DNA-protein interactions

Beuck, C and Singh, I. and Bhattacharya, A and Heckler, W and Parmar, VS and Seitz, O and Weinhold, E (2003) Polycyclic aromatic DNA-Base surrogates: high-affinity binding to an adenine-specific base-flipping DNA methyltransferase. Angewandte Chemie International Edition, 42 (33). pp. 3958-3960. ISSN 1433-7851

Delta-9-tetrahydrocannabinol

Athanasiou, Andriani and Clarke, Anna B. and Turner, Amy E. and Kumaran, Nethia M. and Vakilpour, Sara and Smith, Paul A. and Bagiokou, Dimitra and Bradshaw, Tracey D. and Westwell, Andrew D. and Fang, Lin and Lobo, Dileep N. and Constantinescu, Cris S. and Calabrese, Vittorio and Loesch, Andrzej and Alexander, Stephen P. H. and Clothier, Richard H. and Kendall, David A. and Bates, Timothy E. (2007) Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications, 364 (1). pp. 131-137. ISSN 0006-291x

Derivatisation

Elie, Mathieu Pierre and Baron, Mark G. and Birkett, Jason W. (2012) Injection port silylation of γ-hydroxybutyrate and trans-hydroxycrotonic acid: Conditions optimisation and characterisation of the di-tert-butyldimethylsilyl derivatives by GC-MS. Analyst, 137 (1). p. 255. ISSN 0003-2654

Derivative

Elie, Mathieu Pierre and Baron, Mark G. and Birkett, Jason W. (2012) Injection port silylation of γ-hydroxybutyrate and trans-hydroxycrotonic acid: Conditions optimisation and characterisation of the di-tert-butyldimethylsilyl derivatives by GC-MS. Analyst, 137 (1). p. 255. ISSN 0003-2654

Diaminopyrimidine antibiotic

Lappin, G. and Boyce, M. J. and Matzow, T. and Lociuro, S. and Seymour, M. and Warrington, S. J. (2013) A microdose study of 14C-AR-709 in healthy men: pharmacokinetics, absolute bioavailability and concentrations in key compartments of the lung. European Journal of Clinical Pharmacology, 69 (9). pp. 1673-1682. ISSN 0031-6970

Disease Progression

Golding, C. V. P. and Danchaivijitr, C. and Hodgson, T. L. and Tabrizi, S. J. and Kennard, C. (2006) Identification of an oculomotor biomarker of preclinical Huntington disease. Neurology, 67 (3). pp. 485-487. ISSN 0028-3878

Dissolution

Blagden, N. and de Matas, M. and Gavan, P.T. and York, P. (2007) Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Advanced Drug Delivery Reviews, 59 (7). pp. 617-630. ISSN 0169-409X

Dissolution rates

Blagden, N. and de Matas, M. and Gavan, P.T. and York, P. (2007) Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Advanced Drug Delivery Reviews, 59 (7). pp. 617-630. ISSN 0169-409X

Dodecylmaltoside

Vllasaliu, Driton and Shubber, Saif and Fowler, Robyn and Garnett, Martin and Alexander, Cameron and Stolnik, Snow (2013) Epithelial toxicity of alkylglycoside surfactants. Journal of Pharmaceutical Sciences, 102 (1). pp. 114-125. ISSN 0975-1459

Dog

van Ravenzwaay, B. and Hardwick, T. D. and Needham, D. and Pethen, S. and Lappin, G. J. (2003) Comparative metabolism of 2,4-dichlorophenoxyacetic acid (2,4-D) in rat and dog. Xenobiotica: the fate of foreign compounds in biological systems, 33 (8). pp. 805-21. ISSN 0049-8254

Dose-Response Relationship, Drug

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Drug Design

Blagden, N. and de Matas, M. and Gavan, P.T. and York, P. (2007) Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Advanced Drug Delivery Reviews, 59 (7). pp. 617-630. ISSN 0169-409X

Drug Monitoring

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Drug Stability

Ali, Hany S. M. and York, Peter and Blagden, Nicholas (2009) Preparation of hydrocortisone nanosuspension through a bottom-up nanoprecipitation technique using microfluidic reactors. International Journal of Pharmaceutics, 375 (1-2). pp. 107-113. ISSN 0378-5173

Drug Storage

Ali, Hany S. M. and York, Peter and Blagden, Nicholas (2009) Preparation of hydrocortisone nanosuspension through a bottom-up nanoprecipitation technique using microfluidic reactors. International Journal of Pharmaceutics, 375 (1-2). pp. 107-113. ISSN 0378-5173

Drug delivery

Blagden, N. and de Matas, M. and Gavan, P.T. and York, P. (2007) Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Advanced Drug Delivery Reviews, 59 (7). pp. 617-630. ISSN 0169-409X

Casettari, Luca and Vllasaliu, Driton and Castagnino, Enzo and Stolnik, Snjezana and Howdle, Steven and Illum, Lisbeth (2012) PEGylated chitosan derivatives: synthesis, characterizations and pharmaceutical applications. Progress in Polymer Science, 37 (5). pp. 659-685. ISSN 0079-6700

Casettari, Luca and Vllasaliu, Driton and Lam, Jenny K. W. and Soliman, Mahmoud and Illum, Lisbeth (2012) Biomedical applications of amino acid-modified chitosans: a review. Biomaterials, 33 (30). pp. 7565-7583. ISSN 0142-9612

Garnett, Martin and Vllasaliu, Driton and Stolnik, Snow and Falcone, Franco (2014) Drug delivery: epithelial cell models for drug transport and toxicology studies. The Biochemist, 36 (3). p. 8. ISSN 0954-982X

Vllasaliu, Driton and Fowler, Robyn and Stolnik, Snjezana (2014) PEGylated nanomedicines: recent progress and remaining concerns. Expert Opinion on Drug Delivery, 11 (1). pp. 139-154. ISSN 1742-5247

Drug products

Lappin, Graham and Garner, R. Colin (2004) Current perspectives of 14C-isotope measurement in biomedical accelerator mass spectrometry. Analytical and Bioanalytical Chemistry, 378 (2). pp. 356-364. ISSN 1618-2642

Drug products plants

Davey, R. J. and Blagden, N. and Righini, S. and Alison, H. and Ferrari, E. S. (2002) Nucleation control in solution mediated polymorphic phase transformations: the case of 2,6-dihydroxybenzoic acid. Journal of Physical Chemistry B, 106 (8). pp. 1954-1959. ISSN 1520-6106

Dyes

Baron, M. G. and Elie, M. (2003) Temperature sensing using reversible thermochromic polymeric films. Sensors and Actuators, B: Chemical, 90 (1-3). pp. 271-275. ISSN 0925-4005

EM

Bates, T. E. and Loesch, A. and Burnstock, G. and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochemical and biophysical research communications, 218 (1). pp. 40-44. ISSN 0006-291X

Elastic properties

Soon, C. F. and Youseffi, M. and Blagden, N. and Lobo, S. B. and Javid, F. A. and Denyer, M. C. T. (2009) Interactions of cells with elastic cholesteryl liquid crystals. In: World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany.

Elasticity

Soon, C. F. and Youseffi, M. and Blagden, N. and Lobo, S. B. and Javid, F. A. and Denyer, M. C. T. (2009) Interactions of cells with elastic cholesteryl liquid crystals. In: World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany.

Electron Microscopy

Bates, T. E. and Loesch, A. and Burnstock, G. and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochemical and biophysical research communications, 218 (1). pp. 40-44. ISSN 0006-291X

Electron Transport Chain

Allen, Kathryn L. and Almeida, Angeles and Bates, Timothy E. and Clark, John B. (1995) Changes of respiratory chain activity in mitochondrial and synaptosomal fractions isolated from the gerbil brain after graded ischaemia. Journal of neurochemistry, 64 (5). pp. 2222-2229. ISSN 0022-3042

Almeida, A. and Brooks, K. J. and Sammut, I. and Keelan, J. and Davey, G. P. and Clark, J. B. and Bates, T. E. (1995) Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain. Developmental Neuroscience, 17 (4). pp. 212-218. ISSN 0378-5866

Almeida, Angeles and Allen, Kathryn L. and Bates, TImothy E. and Clark, John B. (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. Journal of neurochemistry, 65 (4). pp. 1698-1703. ISSN 0022-3042

Enterococcus faecium

Williams, David R. and Chanos, P. (2012) Application of anti-listerial bacteriocins: monitoring enterocin expression by multiplex relative reverse transcription-PCR. Biochemical Society Transactions, 40 (6). pp. 1544-1548. ISSN 0300-5127

Enzymes

Rose, Peter and Faulkner, Kathy and Williamson, Gary and Mithen, Gary (2000) 7-Methylsulfinylheptyl and 8-methylsulfinyloctyl isothiocyanates from watercress are potent inducers of phase II enzymes. Carcinogenesis, 21 (11). pp. 1983-1988. ISSN 0143-3334

Epipolythiodioxopiperazine

Davis, Carol and Gordon, Natasha and Murphy, Sinead and Singh, Ishwar and Kavanagh, Kevin and Carberry, Stephen and Doyle, Sean (2011) Single-pot derivatisation strategy for enhanced gliotoxin detection by HPLC and MALDI-ToF mass spectrometry. Analytical and Bioanalytical Chemistry, 401 (8). pp. 2519-2529. ISSN 1618-2642

Epithelial barrier

Vllasaliu, Driton and Fowler, Robyn and Garnett, Martin and Eaton , Mike and Stolnik, Snow (2011) Barrier characteristics of epithelial cultures modelling the airway and intestinal mucosa: a comparison. Biochemical and Biophysical Research Communications, 415 (4). pp. 579-585. ISSN 0006-291X

Epithelial models

Garnett, Martin and Vllasaliu, Driton and Stolnik, Snow and Falcone, Franco (2014) Drug delivery: epithelial cell models for drug transport and toxicology studies. The Biochemist, 36 (3). p. 8. ISSN 0954-982X

Epithelial permeability

Garnett, Martin and Vllasaliu, Driton and Stolnik, Snow and Falcone, Franco (2014) Drug delivery: epithelial cell models for drug transport and toxicology studies. The Biochemist, 36 (3). p. 8. ISSN 0954-982X

Vllasaliu, Driton and Shubber, Saif and Fowler, Robyn and Garnett, Martin and Alexander, Cameron and Stolnik, Snow (2013) Epithelial toxicity of alkylglycoside surfactants. Journal of Pharmaceutical Sciences, 102 (1). pp. 114-125. ISSN 0975-1459

Estradiol

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Excipients

Ali, Hany S. M. and York, Peter and Blagden, Nicholas (2009) Preparation of hydrocortisone nanosuspension through a bottom-up nanoprecipitation technique using microfluidic reactors. International Journal of Pharmaceutics, 375 (1-2). pp. 107-113. ISSN 0378-5173

Extracellular matrix protein

Soon, C. F. and Omar, W. I. W. and Berends, R. F. and Nayan, N. and Basri, H. and Tee, K. S. and Youseffi, M. and Blagden, Nicholas and Denyer, M. C. T. (2014) Biophysical characteristics of cells cultured on cholesteryl ester liquid crystals. Micron, 56 . pp. 73-79. ISSN 0968-4328

Soon, C. F. and Youseffi, M. and Blagden, N. and Lobo, S. B. and Javid, F. A. and Denyer, M. C. T. (2009) Interactions of cells with elastic cholesteryl liquid crystals. In: World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany.

FTIR

Soon, C. F. and Omar, W. I. W. and Berends, R. F. and Nayan, N. and Basri, H. and Tee, K. S. and Youseffi, M. and Blagden, Nicholas and Denyer, M. C. T. (2014) Biophysical characteristics of cells cultured on cholesteryl ester liquid crystals. Micron, 56 . pp. 73-79. ISSN 0968-4328

FcRn pathway

Vllasaliu, Driton and Alexander, Cameron and Garnett, Martin and Eaton , Mike and Stolnik, Snow (2012) Fc-mediated transport of nanoparticles across airway epithelial cell layers. Journal of Controlled Release, 158 (3). pp. 479-486. ISSN 0168-3659

Focal adhesions

Soon, C. F. and Youseffi, M. and Blagden, N. and Lobo, S. B. and Javid, F. A. and Denyer, M. C. T. (2009) Interactions of cells with elastic cholesteryl liquid crystals. In: World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany.

Folate ligands

Moradi, Emilia and Vllasaliu, Driton and Garnett, Martin and Falcone, Franco and Stolnik, Snow (2012) Ligand density and clustering effects on endocytosis of folate modified nanoparticles. RSC Advances, 2 (7). pp. 3025-3033. ISSN 2046-2069

Food Microbiology

Williams, David R. and Chanos, P. (2012) Application of anti-listerial bacteriocins: monitoring enterocin expression by multiplex relative reverse transcription-PCR. Biochemical Society Transactions, 40 (6). pp. 1544-1548. ISSN 0300-5127

Foodborne Diseases

Williams, David R. and Chanos, P. (2012) Application of anti-listerial bacteriocins: monitoring enterocin expression by multiplex relative reverse transcription-PCR. Biochemical Society Transactions, 40 (6). pp. 1544-1548. ISSN 0300-5127

Fructose

Bates, T. E. and Williams, S. R. and Busza, A. L. and Gadian, D. G. and Proctor, E. (1988) A 31P nuclear magnetic resonance study in vivo of metabolic abnormalities in rats with acute liver failure. NMR in biomedicine, 1 (2). pp. 67-73. ISSN 0952-3480

GABA Modulators

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

GC-MS

Elie, Mathieu Pierre and Baron, Mark G. and Birkett, Jason W. (2012) Injection port silylation of γ-hydroxybutyrate and trans-hydroxycrotonic acid: Conditions optimisation and characterisation of the di-tert-butyldimethylsilyl derivatives by GC-MS. Analyst, 137 (1). p. 255. ISSN 0003-2654

GCM

Elie, Mathieu Pierre and Baron, Mark G. and Birkett, Jason W. (2012) Injection port silylation of γ-hydroxybutyrate and trans-hydroxycrotonic acid: Conditions optimisation and characterisation of the di-tert-butyldimethylsilyl derivatives by GC-MS. Analyst, 137 (1). p. 255. ISSN 0003-2654

GHB concentration

Elie, Mathieu Pierre and Baron, Mark G. and Birkett, Jason W. (2012) Injection port silylation of γ-hydroxybutyrate and trans-hydroxycrotonic acid: Conditions optimisation and characterisation of the di-tert-butyldimethylsilyl derivatives by GC-MS. Analyst, 137 (1). p. 255. ISSN 0003-2654

GSH

Heales, S. J. and Davies, S. E. and Bates, T. E. and Clark, J. B. (1995) Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration. Neurochemical research, 20 (1). pp. 31-38. ISSN 0364-3190

Gamma-hydroxybutyrate

Elie, Mathieu Pierre and Baron, Mark G. and Birkett, Jason W. (2012) Injection port silylation of γ-hydroxybutyrate and trans-hydroxycrotonic acid: Conditions optimisation and characterisation of the di-tert-butyldimethylsilyl derivatives by GC-MS. Analyst, 137 (1). p. 255. ISSN 0003-2654

Gene delivery

Casettari, Luca and Vllasaliu, Driton and Castagnino, Enzo and Stolnik, Snjezana and Howdle, Steven and Illum, Lisbeth (2012) PEGylated chitosan derivatives: synthesis, characterizations and pharmaceutical applications. Progress in Polymer Science, 37 (5). pp. 659-685. ISSN 0079-6700

Gene therapy

Casettari, Luca and Vllasaliu, Driton and Lam, Jenny K. W. and Soliman, Mahmoud and Illum, Lisbeth (2012) Biomedical applications of amino acid-modified chitosans: a review. Biomaterials, 33 (30). pp. 7565-7583. ISSN 0142-9612

Glass

Soon, Chin Phong and Khaghani, Seyed Ali and Youseffi, Mansour and Nayan, Nafarizal and Saim, Hashim and Britland, Stephen and Blagden, Nicholas and Denyer, Morgan Clive Thomas (2013) Interfacial study of cell adhesion to liquid crystals using widefield surface plasmon resonance microscopy. Colloids and Surfaces B: Biointerfaces, 110 . pp. 156-162. ISSN 0927-7765

Gliotoxin

Davis, Carol and Gordon, Natasha and Murphy, Sinead and Singh, Ishwar and Kavanagh, Kevin and Carberry, Stephen and Doyle, Sean (2011) Single-pot derivatisation strategy for enhanced gliotoxin detection by HPLC and MALDI-ToF mass spectrometry. Analytical and Bioanalytical Chemistry, 401 (8). pp. 2519-2529. ISSN 1618-2642

Glutamate receptors

Rosin, Claudia and Bates, Timothy E. and Skaper, Stephen D. (2004) Excitatory amino acid induced oligodendrocyte cell death in vitro: receptor-dependent and -independent mechanisms. Journal of Neurochemistry, 90 (5). pp. 1173-1185. ISSN 0022-3042

Glutathione

Heales, S. J. and Davies, S. E. and Bates, T. E. and Clark, J. B. (1995) Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration. Neurochemical research, 20 (1). pp. 31-38. ISSN 0364-3190

Glycosides

Hainke, Sven and Singh, Ishwar and Hemmings, Jennifer and Seitz, Oliver (2007) Synthesis of C-aryl-nucleosides and O-aryl-glycosides via cuprate glycosylation. Journal of Organic Chemistry, 72 (23). pp. 8811-8819. ISSN 0022-3263

Good correlations

Soon, C. F. and Youseffi, M. and Blagden, N. and Lobo, S. B. and Javid, F. A. and Denyer, M. C. T. (2009) Interactions of cells with elastic cholesteryl liquid crystals. In: World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany.

Guinea pig ileum

Broadley, Kenneth J. and Grassby, Paul F. (1985) Alpha- and beta-adrenoceptor-mediated responses of the guinea-pig ileum and the effects of neuronal uptake inhibition. Naunyn-Schmiedeberg's Archives of Pharmacology, 331 (4). pp. 316-323. ISSN 0028-1298

H202

Bates, T. E. and Heales, S. J. and Davies, S. E. and Boakye, P. and Clark, J. B. (1994) Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. Journal of neurochemistry, 63 (2). pp. 640-648. ISSN 0022-3042

H460

Athanasiou, Andriani and Clarke, Anna B. and Turner, Amy E. and Kumaran, Nethia M. and Vakilpour, Sara and Smith, Paul A. and Bagiokou, Dimitra and Bradshaw, Tracey D. and Westwell, Andrew D. and Fang, Lin and Lobo, Dileep N. and Constantinescu, Cris S. and Calabrese, Vittorio and Loesch, Andrzej and Alexander, Stephen P. H. and Clothier, Richard H. and Kendall, David A. and Bates, Timothy E. (2007) Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications, 364 (1). pp. 131-137. ISSN 0006-291x

Athanasiou, Andriani and Smith, Paul A. and Vakilpour, Sara and Kumaran, Nethia M. and Turner, Amy E. and Bagiokou, Dimitra and Layfield, Robert and Ray, David E. and Westwell, Andrew D. and Alexander, Stephen P. H. and Kendall, David A. and Lobo, Dileep N. and Watson, Susan A. and Lophatanon, Artitaya and Muir, Kenneth A. and Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

HU 210

Athanasiou, Andriani and Clarke, Anna B. and Turner, Amy E. and Kumaran, Nethia M. and Vakilpour, Sara and Smith, Paul A. and Bagiokou, Dimitra and Bradshaw, Tracey D. and Westwell, Andrew D. and Fang, Lin and Lobo, Dileep N. and Constantinescu, Cris S. and Calabrese, Vittorio and Loesch, Andrzej and Alexander, Stephen P. H. and Clothier, Richard H. and Kendall, David A. and Bates, Timothy E. (2007) Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications, 364 (1). pp. 131-137. ISSN 0006-291x

Heart

Bates, T. E. and Loesch, A. and Burnstock, G. and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochemical and biophysical research communications, 218 (1). pp. 40-44. ISSN 0006-291X

High-resolution imaging

Soon, Chin Phong and Khaghani, Seyed Ali and Youseffi, Mansour and Nayan, Nafarizal and Saim, Hashim and Britland, Stephen and Blagden, Nicholas and Denyer, Morgan Clive Thomas (2013) Interfacial study of cell adhesion to liquid crystals using widefield surface plasmon resonance microscopy. Colloids and Surfaces B: Biointerfaces, 110 . pp. 156-162. ISSN 0927-7765

Human keratinocytes

Soon, C. F. and Youseffi, M. and Blagden, N. and Lobo, S. B. and Javid, F. A. and Denyer, M. C. T. (2009) Interactions of cells with elastic cholesteryl liquid crystals. In: World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany.

Humans

Golding, C. V. P. and Danchaivijitr, C. and Hodgson, T. L. and Tabrizi, S. J. and Kennard, C. (2006) Identification of an oculomotor biomarker of preclinical Huntington disease. Neurology, 67 (3). pp. 485-487. ISSN 0028-3878

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Rose, Peter and Whiteman, Matt and Moore, Philip K. and Yi, Zhun Zhu (2005) Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents. Natural Product Reports, 22 (3). pp. 351-368. ISSN 0265-0568

Schon, F. and Hart, P. E. and Hodgson, T. L. and Pambakian, A. L. M. and Ruprah, M. and Williamson, E.M. and Kennard, C. (1999) Suppression of pendular nystagmus by smoking cannabis in a patient with multiple sclerosis. Neurology, 53 (9). pp. 2209-2210. ISSN 0028-3878

Williams, David R. and Chanos, P. (2012) Application of anti-listerial bacteriocins: monitoring enterocin expression by multiplex relative reverse transcription-PCR. Biochemical Society Transactions, 40 (6). pp. 1544-1548. ISSN 0300-5127

Huntington Disease

Golding, C. V. P. and Danchaivijitr, C. and Hodgson, T. L. and Tabrizi, S. J. and Kennard, C. (2006) Identification of an oculomotor biomarker of preclinical Huntington disease. Neurology, 67 (3). pp. 485-487. ISSN 0028-3878

Huntington chorea

Golding, C. V. P. and Danchaivijitr, C. and Hodgson, T. L. and Tabrizi, S. J. and Kennard, C. (2006) Identification of an oculomotor biomarker of preclinical Huntington disease. Neurology, 67 (3). pp. 485-487. ISSN 0028-3878

Hydrocortisone

Ali, Hany S. M. and York, Peter and Blagden, Nicholas (2009) Preparation of hydrocortisone nanosuspension through a bottom-up nanoprecipitation technique using microfluidic reactors. International Journal of Pharmaceutics, 375 (1-2). pp. 107-113. ISSN 0378-5173

Hydrogen bonds

Seaton, Colin C. and Blagden, Nicholas and Munshi, Tasnim and Scowen, Ian J. (2013) Creation of ternary multicomponent crystals by exploitation of charge-transfer interactions. Chemistry - A European Journal, 19 (32). pp. 10663-10671. ISSN 0947-6539

Hydrogen chloride

Baron, M. G. and Narayanaswamy, R. and Thorpe, S. C. (1996) Hydrophobic membrane sensors for the optical determination of hydrogen chloride gas. Sensors and Actuators, B: Chemical, 34 (1-3). pp. 511-515. ISSN 0925-4005

Hydrogen peroxide

Bates, T. E. and Heales, S. J. and Davies, S. E. and Boakye, P. and Clark, J. B. (1994) Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. Journal of neurochemistry, 63 (2). pp. 640-648. ISSN 0022-3042

Hydroxybutyrate

Elie, Mathieu Pierre and Baron, Mark G. and Birkett, Jason W. (2012) Injection port silylation of γ-hydroxybutyrate and trans-hydroxycrotonic acid: Conditions optimisation and characterisation of the di-tert-butyldimethylsilyl derivatives by GC-MS. Analyst, 137 (1). p. 255. ISSN 0003-2654

IgG

Vllasaliu, Driton and Alexander, Cameron and Garnett, Martin and Eaton , Mike and Stolnik, Snow (2012) Fc-mediated transport of nanoparticles across airway epithelial cell layers. Journal of Controlled Release, 158 (3). pp. 479-486. ISSN 0168-3659

Image reconstruction

Soon, Chin Phong and Khaghani, Seyed Ali and Youseffi, Mansour and Nayan, Nafarizal and Saim, Hashim and Britland, Stephen and Blagden, Nicholas and Denyer, Morgan Clive Thomas (2013) Interfacial study of cell adhesion to liquid crystals using widefield surface plasmon resonance microscopy. Colloids and Surfaces B: Biointerfaces, 110 . pp. 156-162. ISSN 0927-7765

Imaging systems

Soon, Chin Phong and Khaghani, Seyed Ali and Youseffi, Mansour and Nayan, Nafarizal and Saim, Hashim and Britland, Stephen and Blagden, Nicholas and Denyer, Morgan Clive Thomas (2013) Interfacial study of cell adhesion to liquid crystals using widefield surface plasmon resonance microscopy. Colloids and Surfaces B: Biointerfaces, 110 . pp. 156-162. ISSN 0927-7765

Immumnoelectron microscopy

Bates, T. E. and Loesch, A. and Burnstock, G. and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochemical and biophysical research communications, 218 (1). pp. 40-44. ISSN 0006-291X

Immunocytochemistry

Bates, T. E. and Loesch, A. and Burnstock, G. and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochemical and biophysical research communications, 218 (1). pp. 40-44. ISSN 0006-291X

Immunofluorescence staining

Soon, Chin Phong and Khaghani, Seyed Ali and Youseffi, Mansour and Nayan, Nafarizal and Saim, Hashim and Britland, Stephen and Blagden, Nicholas and Denyer, Morgan Clive Thomas (2013) Interfacial study of cell adhesion to liquid crystals using widefield surface plasmon resonance microscopy. Colloids and Surfaces B: Biointerfaces, 110 . pp. 156-162. ISSN 0927-7765

In situ crystallization

David, W. I. F. and Shankland, K. and Pulham, C. R. and Blagden, N. and Davey, R. J. and Song, M. (2005) Polymorphism in benzamide. Angewandte Chemie - International Edition, 44 (43). pp. 7032-7035. ISSN 1433-7851

Injection

Elie, Mathieu Pierre and Baron, Mark G. and Birkett, Jason W. (2012) Injection port silylation of γ-hydroxybutyrate and trans-hydroxycrotonic acid: Conditions optimisation and characterisation of the di-tert-butyldimethylsilyl derivatives by GC-MS. Analyst, 137 (1). p. 255. ISSN 0003-2654

Injection port

Elie, Mathieu Pierre and Baron, Mark G. and Birkett, Jason W. (2012) Injection port silylation of γ-hydroxybutyrate and trans-hydroxycrotonic acid: Conditions optimisation and characterisation of the di-tert-butyldimethylsilyl derivatives by GC-MS. Analyst, 137 (1). p. 255. ISSN 0003-2654

Injections, Intravenous

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Integrins

Soon, C. F. and Omar, W. I. W. and Berends, R. F. and Nayan, N. and Basri, H. and Tee, K. S. and Youseffi, M. and Blagden, Nicholas and Denyer, M. C. T. (2014) Biophysical characteristics of cells cultured on cholesteryl ester liquid crystals. Micron, 56 . pp. 73-79. ISSN 0968-4328

Interfacial interaction

Soon, Chin Phong and Khaghani, Seyed Ali and Youseffi, Mansour and Nayan, Nafarizal and Saim, Hashim and Britland, Stephen and Blagden, Nicholas and Denyer, Morgan Clive Thomas (2013) Interfacial study of cell adhesion to liquid crystals using widefield surface plasmon resonance microscopy. Colloids and Surfaces B: Biointerfaces, 110 . pp. 156-162. ISSN 0927-7765

Ischaemia

Allen, Kathryn L. and Almeida, Angeles and Bates, Timothy E. and Clark, John B. (1995) Changes of respiratory chain activity in mitochondrial and synaptosomal fractions isolated from the gerbil brain after graded ischaemia. Journal of neurochemistry, 64 (5). pp. 2222-2229. ISSN 0022-3042

Almeida, Angeles and Allen, Kathryn L. and Bates, TImothy E. and Clark, John B. (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. Journal of neurochemistry, 65 (4). pp. 1698-1703. ISSN 0022-3042

Brooks, Keith J. and Hargreaves, Iain P. and Bates, Timothy E. (2008) Protection of respiratory chain enzymes from ischaemic damage in adult rat brain slices. Neurochemical research, 33 (9). pp. 1711-1716. ISSN 0364-3190

Ischemia

Allen, Kathryn L. and Almeida, Angeles and Bates, Timothy E. and Clark, John B. (1995) Changes of respiratory chain activity in mitochondrial and synaptosomal fractions isolated from the gerbil brain after graded ischaemia. Journal of neurochemistry, 64 (5). pp. 2222-2229. ISSN 0022-3042

Almeida, Angeles and Allen, Kathryn L. and Bates, TImothy E. and Clark, John B. (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. Journal of neurochemistry, 65 (4). pp. 1698-1703. ISSN 0022-3042

Brooks, Keith J. and Hargreaves, Iain P. and Bates, Timothy E. (2008) Protection of respiratory chain enzymes from ischaemic damage in adult rat brain slices. Neurochemical research, 33 (9). pp. 1711-1716. ISSN 0364-3190

Isotopes

Lappin, Graham and Garner, R. Colin (2004) Current perspectives of 14C-isotope measurement in biomedical accelerator mass spectrometry. Analytical and Bioanalytical Chemistry, 378 (2). pp. 356-364. ISSN 1618-2642

Keratinocytes

Soon, Chin Phong and Khaghani, Seyed Ali and Youseffi, Mansour and Nayan, Nafarizal and Saim, Hashim and Britland, Stephen and Blagden, Nicholas and Denyer, Morgan Clive Thomas (2013) Interfacial study of cell adhesion to liquid crystals using widefield surface plasmon resonance microscopy. Colloids and Surfaces B: Biointerfaces, 110 . pp. 156-162. ISSN 0927-7765

Kidney

Bates, T. E. and Loesch, A. and Burnstock, G. and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochemical and biophysical research communications, 218 (1). pp. 40-44. ISSN 0006-291X

Kinetics

Dematos, Luciana L. and Williams, Adrian C. and Booth, Steven W. and Petts, Catherine R. and Taylor, David J. and Blagden, Nicholas (2007) Solvent influences on metastable polymorph lifetimes: real-time interconversions using energy dispersive X-ray diffractometry. Journal of Pharmaceutical Sciences, 96 (5). pp. 1069-1078. ISSN 0022-3549

L-buthionine sulfoximine

Heales, S. J. and Davies, S. E. and Bates, T. E. and Clark, J. B. (1995) Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration. Neurochemical research, 20 (1). pp. 31-38. ISSN 0364-3190

Ligand density

Moradi, Emilia and Vllasaliu, Driton and Garnett, Martin and Falcone, Franco and Stolnik, Snow (2012) Ligand density and clustering effects on endocytosis of folate modified nanoparticles. RSC Advances, 2 (7). pp. 3025-3033. ISSN 2046-2069

Linear elasticity

Soon, C. F. and Youseffi, M. and Blagden, N. and Lobo, S. B. and Javid, F. A. and Denyer, M. C. T. (2009) Interactions of cells with elastic cholesteryl liquid crystals. In: World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany.

Liposomes

Vllasaliu, Driton and Fowler, Robyn and Stolnik, Snjezana (2014) PEGylated nanomedicines: recent progress and remaining concerns. Expert Opinion on Drug Delivery, 11 (1). pp. 139-154. ISSN 1742-5247

Liquid crystals

Soon, C. F. and Omar, W. I. W. and Berends, R. F. and Nayan, N. and Basri, H. and Tee, K. S. and Youseffi, M. and Blagden, Nicholas and Denyer, M. C. T. (2014) Biophysical characteristics of cells cultured on cholesteryl ester liquid crystals. Micron, 56 . pp. 73-79. ISSN 0968-4328

Soon, C. F. and Youseffi, M. and Blagden, N. and Lobo, S. B. and Javid, F. A. and Denyer, M. C. T. (2009) Interactions of cells with elastic cholesteryl liquid crystals. In: World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany.

Soon, Chin Phong and Khaghani, Seyed Ali and Youseffi, Mansour and Nayan, Nafarizal and Saim, Hashim and Britland, Stephen and Blagden, Nicholas and Denyer, Morgan Clive Thomas (2013) Interfacial study of cell adhesion to liquid crystals using widefield surface plasmon resonance microscopy. Colloids and Surfaces B: Biointerfaces, 110 . pp. 156-162. ISSN 0927-7765

Listeria

Williams, David R. and Chanos, P. (2012) Application of anti-listerial bacteriocins: monitoring enterocin expression by multiplex relative reverse transcription-PCR. Biochemical Society Transactions, 40 (6). pp. 1544-1548. ISSN 0300-5127

Liver

Bates, T. E and Loesch, A. and Burnstock, G. and Clark, J. B. (1995) Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver. Biochemical and biophysical research communications, 213 (3). pp. 896-900. ISSN 0006-291X

Bates, Timothy E. and Williams, Stephen R. and Gadian, David G. (1989) Phosphodiesters in the liver: the effect of field strength on the 31P signal. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 12 (1). pp. 145-150. ISSN 0740-3194

Murphy, Elizabeth J. and Bates, Timothy E. and Williams, Stephen R. and Watson, Tracey and Brindle, Kevin M. and Rajagopalan, Bheeshma and Radda, George K. (1992) Endoplasmic reticulum: the major contributor to the PDE peak in hepatic 31P-NMR spectra at low magnetic field strengths. Biochimica et biophysica acta: biomembranes, 1111 (1). pp. 51-58. ISSN 0005-2736

MPP+

Bates, T. E. and Heales, S. J. and Davies, S. E. and Boakye, P. and Clark, J. B. (1994) Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. Journal of neurochemistry, 63 (2). pp. 640-648. ISSN 0022-3042

MPTP

Bates, T. E. and Heales, S. J. and Davies, S. E. and Boakye, P. and Clark, J. B. (1994) Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. Journal of neurochemistry, 63 (2). pp. 640-648. ISSN 0022-3042

MRS

Bates, T. E. and Williams, S. R. and Busza, A. L. and Gadian, D. G. and Proctor, E. (1988) A 31P nuclear magnetic resonance study in vivo of metabolic abnormalities in rats with acute liver failure. NMR in biomedicine, 1 (2). pp. 67-73. ISSN 0952-3480

Macromolecular permeability

Vllasaliu, Driton and Fowler, Robyn and Garnett, Martin and Eaton , Mike and Stolnik, Snow (2011) Barrier characteristics of epithelial cultures modelling the airway and intestinal mucosa: a comparison. Biochemical and Biophysical Research Communications, 415 (4). pp. 579-585. ISSN 0006-291X

Magnetic field strength

Bates, Timothy E. and Williams, Stephen R. and Gadian, David G. (1989) Phosphodiesters in the liver: the effect of field strength on the 31P signal. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 12 (1). pp. 145-150. ISSN 0740-3194

Mammalia

Rose, Peter and Whiteman, Matt and Moore, Philip K. and Yi, Zhun Zhu (2005) Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents. Natural Product Reports, 22 (3). pp. 351-368. ISSN 0265-0568

Marijuana Smoking

Schon, F. and Hart, P. E. and Hodgson, T. L. and Pambakian, A. L. M. and Ruprah, M. and Williamson, E.M. and Kennard, C. (1999) Suppression of pendular nystagmus by smoking cannabis in a patient with multiple sclerosis. Neurology, 53 (9). pp. 2209-2210. ISSN 0028-3878

Mass spectrometry

Lappin, Graham and Garner, R. Colin (2004) Current perspectives of 14C-isotope measurement in biomedical accelerator mass spectrometry. Analytical and Bioanalytical Chemistry, 378 (2). pp. 356-364. ISSN 1618-2642

Mechanics

Soon, C. F. and Youseffi, M. and Blagden, N. and Lobo, S. B. and Javid, F. A. and Denyer, M. C. T. (2009) Interactions of cells with elastic cholesteryl liquid crystals. In: World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany.

Medical applications

Lappin, Graham and Garner, R. Colin (2004) Current perspectives of 14C-isotope measurement in biomedical accelerator mass spectrometry. Analytical and Bioanalytical Chemistry, 378 (2). pp. 356-364. ISSN 1618-2642

Medicinal chemistr

Singh, Ishwar and Freeman, Colin and Heaney, Frances (2011) Efficient synthesis of DNA conjugates by strain-promoted azide-cyclooctyne cycloaddition in the solid phase. European Journal of Organic Chemistry (33). pp. 6739-6746. ISSN 1434-193X

Metabolism

Lappin, Graham (2011) Microdosing: pharmacokinetic and metabolism data early in the drug development process. In: Pharmacokinetics in drug development: advanves and applications. Pharmacokinetics in Drug Development (3). Springer, New York. ISBN 9781441979377

Lappin, Graham and Garner, R. Colin (2004) Current perspectives of 14C-isotope measurement in biomedical accelerator mass spectrometry. Analytical and Bioanalytical Chemistry, 378 (2). pp. 356-364. ISSN 1618-2642

van Ravenzwaay, B. and Hardwick, T. D. and Needham, D. and Pethen, S. and Lappin, G. J. (2003) Comparative metabolism of 2,4-dichlorophenoxyacetic acid (2,4-D) in rat and dog. Xenobiotica: the fate of foreign compounds in biological systems, 33 (8). pp. 805-21. ISSN 0049-8254

Metal free porphyrin

Baron, M. G. and Narayanaswamy, R. and Thorpe, S. C. (1996) Hydrophobic membrane sensors for the optical determination of hydrogen chloride gas. Sensors and Actuators, B: Chemical, 34 (1-3). pp. 511-515. ISSN 0925-4005

Metastable polymorphs

Blagden, N. and de Matas, M. and Gavan, P.T. and York, P. (2007) Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Advanced Drug Delivery Reviews, 59 (7). pp. 617-630. ISSN 0169-409X

Methane

Dematos, Luciana L. and Williams, Adrian C. and Booth, Steven W. and Petts, Catherine R. and Taylor, David J. and Blagden, Nicholas (2007) Solvent influences on metastable polymorph lifetimes: real-time interconversions using energy dispersive X-ray diffractometry. Journal of Pharmaceutical Sciences, 96 (5). pp. 1069-1078. ISSN 0022-3549

Microdose

Lappin, G. and Boyce, M. J. and Matzow, T. and Lociuro, S. and Seymour, M. and Warrington, S. J. (2013) A microdose study of 14C-AR-709 in healthy men: pharmacokinetics, absolute bioavailability and concentrations in key compartments of the lung. European Journal of Clinical Pharmacology, 69 (9). pp. 1673-1682. ISSN 0031-6970

Microdosing

Lappin, Graham (2010) Pharmacokinetics II: 14C-labelled microdosing in assessing drug pharmacokinetics at phase-0. In: Clinical Pharmacology, Current Topics and Case Studies. Springer, pp. 155-165. ISBN 9783709101438

Lappin, Graham and Garner, R. Colin (2004) Current perspectives of 14C-isotope measurement in biomedical accelerator mass spectrometry. Analytical and Bioanalytical Chemistry, 378 (2). pp. 356-364. ISSN 1618-2642

Middle Aged

Golding, C. V. P. and Danchaivijitr, C. and Hodgson, T. L. and Tabrizi, S. J. and Kennard, C. (2006) Identification of an oculomotor biomarker of preclinical Huntington disease. Neurology, 67 (3). pp. 485-487. ISSN 0028-3878

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Schon, F. and Hart, P. E. and Hodgson, T. L. and Pambakian, A. L. M. and Ruprah, M. and Williamson, E.M. and Kennard, C. (1999) Suppression of pendular nystagmus by smoking cannabis in a patient with multiple sclerosis. Neurology, 53 (9). pp. 2209-2210. ISSN 0028-3878

Mitochondria

Allen, Kathryn L. and Almeida, Angeles and Bates, Timothy E. and Clark, John B. (1995) Changes of respiratory chain activity in mitochondrial and synaptosomal fractions isolated from the gerbil brain after graded ischaemia. Journal of neurochemistry, 64 (5). pp. 2222-2229. ISSN 0022-3042

Almeida, Angeles and Allen, Kathryn L. and Bates, TImothy E. and Clark, John B. (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. Journal of neurochemistry, 65 (4). pp. 1698-1703. ISSN 0022-3042

Bates, T. E and Loesch, A. and Burnstock, G. and Clark, J. B. (1995) Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver. Biochemical and biophysical research communications, 213 (3). pp. 896-900. ISSN 0006-291X

Bates, T. E. and Heales, S. J. and Davies, S. E. and Boakye, P. and Clark, J. B. (1994) Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. Journal of neurochemistry, 63 (2). pp. 640-648. ISSN 0022-3042

Brooks, Keith J. and Hargreaves, Iain P. and Bates, Timothy E. (2008) Protection of respiratory chain enzymes from ischaemic damage in adult rat brain slices. Neurochemical research, 33 (9). pp. 1711-1716. ISSN 0364-3190

Heales, S. J. and Davies, S. E. and Bates, T. E. and Clark, J. B. (1995) Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration. Neurochemical research, 20 (1). pp. 31-38. ISSN 0364-3190

Molecular Structure

Rose, Peter and Whiteman, Matt and Moore, Philip K. and Yi, Zhun Zhu (2005) Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents. Natural Product Reports, 22 (3). pp. 351-368. ISSN 0265-0568

Mucoadhesion

Vllasaliu, Driton and Casettari, Luca and Fowler, Robyn and Exposito-Harris, Ruth and Garnett, Martin and Illum, Lisbeth and Stolnik, Snow (2012) Absorption-promoting effects of chitosan in airway and intestinal cell lines: a comparative study. International Journal of Pharmaceutics, 430 (1-2). pp. 151-160. ISSN 0378-5173

Mucosal delivery

Vllasaliu, Driton and Alexander, Cameron and Garnett, Martin and Eaton , Mike and Stolnik, Snow (2012) Fc-mediated transport of nanoparticles across airway epithelial cell layers. Journal of Controlled Release, 158 (3). pp. 479-486. ISSN 0168-3659

Vllasaliu, Driton and Fowler, Robyn and Garnett, Martin and Eaton , Mike and Stolnik, Snow (2011) Barrier characteristics of epithelial cultures modelling the airway and intestinal mucosa: a comparison. Biochemical and Biophysical Research Communications, 415 (4). pp. 579-585. ISSN 0006-291X

Mucosal protein delivery

Vllasaliu, Driton and Shubber, Saif and Garnett, Martin and Alexander, Cameron and Eaton, Mike and Stolnik, Snow (2012) Evaluation of calcium depletion as a strategy for enhancement of mucosal absorption of macromolecules. Biochemical and Biophysical Research Communications, 418 (1). pp. 128-133. ISSN 0006-291X

Multicomponent crystals

Seaton, Colin C. and Blagden, Nicholas and Munshi, Tasnim and Scowen, Ian J. (2013) Creation of ternary multicomponent crystals by exploitation of charge-transfer interactions. Chemistry - A European Journal, 19 (32). pp. 10663-10671. ISSN 0947-6539

Multiplex Polymerase Chain Reaction

Williams, David R. and Chanos, P. (2012) Application of anti-listerial bacteriocins: monitoring enterocin expression by multiplex relative reverse transcription-PCR. Biochemical Society Transactions, 40 (6). pp. 1544-1548. ISSN 0300-5127

N omega-nitro-L-arginine

Brooks, Keith J. and Hargreaves, Iain P. and Bates, Timothy E. (2008) Protection of respiratory chain enzymes from ischaemic damage in adult rat brain slices. Neurochemical research, 33 (9). pp. 1711-1716. ISSN 0364-3190

NMR

Murphy, Elizabeth J. and Bates, Timothy E. and Williams, Stephen R. and Watson, Tracey and Brindle, Kevin M. and Rajagopalan, Bheeshma and Radda, George K. (1992) Endoplasmic reticulum: the major contributor to the PDE peak in hepatic 31P-NMR spectra at low magnetic field strengths. Biochimica et biophysica acta: biomembranes, 1111 (1). pp. 51-58. ISSN 0005-2736

NMR Spectroscopy

Bates, T. E. and Williams, S. R. and Busza, A. L. and Gadian, D. G. and Proctor, E. (1988) A 31P nuclear magnetic resonance study in vivo of metabolic abnormalities in rats with acute liver failure. NMR in biomedicine, 1 (2). pp. 67-73. ISSN 0952-3480

Bates, Timothy E. and Williams, Stephen R. and Kauppinen, Risto A. and Gadian, David G. (1989) Observation of cerebral metabolites in an animal model of acute liver failure in vivo: a 1H and 31P nuclear magnetic resonance study. Journal of neurochemistry, 53 (1). pp. 102-10. ISSN 0022-3042

Gadian, D. G. and Bates, T. E. and Williams, S. R. and Bell, J. D. and Austin, S. J. and Connelly, A. (1991) Approaches to editing, assignment and interpretation of proton spectra. NMR in biomedicine, 4 (2). pp. 85-89. ISSN 0952-3480

NMR spectroscopy

Brooks, K. J. and Kauppinen, R. A. and Williams, S. R. and Bachelard, H. S. and Bates, T. E. and Gadian, D. G. (1989) Ammonia causes a drop in intracellular pH in metabolizing cortical brain slices. A [31P]- and [1H]nuclear magnetic resonance study. Neuroscience, 33 (1). pp. 185-192. ISSN 0306-4522

NOS

Bates, T. E and Loesch, A. and Burnstock, G. and Clark, J. B. (1995) Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver. Biochemical and biophysical research communications, 213 (3). pp. 896-900. ISSN 0006-291X

Bates, T. E. and Loesch, A. and Burnstock, G. and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochemical and biophysical research communications, 218 (1). pp. 40-44. ISSN 0006-291X

NRPS

Davis, Carol and Gordon, Natasha and Murphy, Sinead and Singh, Ishwar and Kavanagh, Kevin and Carberry, Stephen and Doyle, Sean (2011) Single-pot derivatisation strategy for enhanced gliotoxin detection by HPLC and MALDI-ToF mass spectrometry. Analytical and Bioanalytical Chemistry, 401 (8). pp. 2519-2529. ISSN 1618-2642

Nanomedicines

Vllasaliu, Driton and Fowler, Robyn and Stolnik, Snjezana (2014) PEGylated nanomedicines: recent progress and remaining concerns. Expert Opinion on Drug Delivery, 11 (1). pp. 139-154. ISSN 1742-5247

Nanoparticle transport

Vllasaliu, Driton and Alexander, Cameron and Garnett, Martin and Eaton , Mike and Stolnik, Snow (2012) Fc-mediated transport of nanoparticles across airway epithelial cell layers. Journal of Controlled Release, 158 (3). pp. 479-486. ISSN 0168-3659

Nanoparticles

Ali, Hany S. M. and York, Peter and Blagden, Nicholas (2009) Preparation of hydrocortisone nanosuspension through a bottom-up nanoprecipitation technique using microfluidic reactors. International Journal of Pharmaceutics, 375 (1-2). pp. 107-113. ISSN 0378-5173

Vllasaliu, Driton and Exposito-Harris, Ruth and Heras, Angeles and Casettari, Luca and Garnett, Martin and Illum, Lisbeth and Stolnik, Snow (2010) Tight junction modulation by chitosan nanoparticles: comparison with chitosan solution. International Journal of Pharmaceutics, 400 (1-2). pp. 183-193. ISSN 0378-5173

Vllasaliu, Driton and Fowler, Robyn and Stolnik, Snjezana (2014) PEGylated nanomedicines: recent progress and remaining concerns. Expert Opinion on Drug Delivery, 11 (1). pp. 139-154. ISSN 1742-5247

Nanotechnology

Ali, Hany S. M. and York, Peter and Blagden, Nicholas (2009) Preparation of hydrocortisone nanosuspension through a bottom-up nanoprecipitation technique using microfluidic reactors. International Journal of Pharmaceutics, 375 (1-2). pp. 107-113. ISSN 0378-5173

Nasal drug delivery

Vllasaliu, Driton and Exposito-Harris, Ruth and Heras, Angeles and Casettari, Luca and Garnett, Martin and Illum, Lisbeth and Stolnik, Snow (2010) Tight junction modulation by chitosan nanoparticles: comparison with chitosan solution. International Journal of Pharmaceutics, 400 (1-2). pp. 183-193. ISSN 0378-5173

Nitric Oxide Synthase

Bates, T. E and Loesch, A. and Burnstock, G. and Clark, J. B. (1995) Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver. Biochemical and biophysical research communications, 213 (3). pp. 896-900. ISSN 0006-291X

Bates, T. E. and Loesch, A. and Burnstock, G. and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochemical and biophysical research communications, 218 (1). pp. 40-44. ISSN 0006-291X

Nitroparaffins

Dematos, Luciana L. and Williams, Adrian C. and Booth, Steven W. and Petts, Catherine R. and Taylor, David J. and Blagden, Nicholas (2007) Solvent influences on metastable polymorph lifetimes: real-time interconversions using energy dispersive X-ray diffractometry. Journal of Pharmaceutical Sciences, 96 (5). pp. 1069-1078. ISSN 0022-3549

Nootropic Agents

Dematos, Luciana L. and Williams, Adrian C. and Booth, Steven W. and Petts, Catherine R. and Taylor, David J. and Blagden, Nicholas (2007) Solvent influences on metastable polymorph lifetimes: real-time interconversions using energy dispersive X-ray diffractometry. Journal of Pharmaceutical Sciences, 96 (5). pp. 1069-1078. ISSN 0022-3549

Novel applications

Soon, C. F. and Youseffi, M. and Blagden, N. and Lobo, S. B. and Javid, F. A. and Denyer, M. C. T. (2009) Interactions of cells with elastic cholesteryl liquid crystals. In: World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany.

Nuclear physics

Lappin, Graham and Garner, R. Colin (2004) Current perspectives of 14C-isotope measurement in biomedical accelerator mass spectrometry. Analytical and Bioanalytical Chemistry, 378 (2). pp. 356-364. ISSN 1618-2642

Nucleation

Davey, R. J. and Blagden, N. and Righini, S. and Alison, H. and Ferrari, E. S. (2002) Nucleation control in solution mediated polymorphic phase transformations: the case of 2,6-dihydroxybenzoic acid. Journal of Physical Chemistry B, 106 (8). pp. 1954-1959. ISSN 1520-6106

Nucleosides

Algay, Virginie and Singh, Ishwar and Heaney, Frances (2010) Nucleoside and nucleotide analogues by catalyst free Huisgen nitrile oxide-alkyne 1,3-dipolar cycloaddition. Organic and Biomolecular Chemistry, 8 (2). pp. 391-397. ISSN 1477-0520

Hainke, Sven and Singh, Ishwar and Hemmings, Jennifer and Seitz, Oliver (2007) Synthesis of C-aryl-nucleosides and O-aryl-glycosides via cuprate glycosylation. Journal of Organic Chemistry, 72 (23). pp. 8811-8819. ISSN 0022-3263

Singh, Ishwar and Heaney, Frances (2010) Metal free, "click and click-click'' conjugation of ribonucleosides and 2'-OMe oligoribonucleotides on the solid phase. Organic and Biomolecular Chemistry, 8 (2). pp. 451-456. ISSN 1477-0520

Nucleotides

Algay, Virginie and Singh, Ishwar and Heaney, Frances (2010) Nucleoside and nucleotide analogues by catalyst free Huisgen nitrile oxide-alkyne 1,3-dipolar cycloaddition. Organic and Biomolecular Chemistry, 8 (2). pp. 391-397. ISSN 1477-0520

Bethge, Lucas and Singh, Ishwar and Seitz, Oliver (2010) Designed thiazole orange nucleotides for the synthesis of single labelled oligonucleotides that fluoresce upon matched hybridization. Organic and Biomolecular Chemistry, 8 (10). pp. 2439-2448. ISSN 1477-0520

Singh, Ishwar and Heaney, Frances (2010) Metal free, "click and click-click'' conjugation of ribonucleosides and 2'-OMe oligoribonucleotides on the solid phase. Organic and Biomolecular Chemistry, 8 (2). pp. 451-456. ISSN 1477-0520

Nystagmus, Pathologic

Schon, F. and Hart, P. E. and Hodgson, T. L. and Pambakian, A. L. M. and Ruprah, M. and Williamson, E.M. and Kennard, C. (1999) Suppression of pendular nystagmus by smoking cannabis in a patient with multiple sclerosis. Neurology, 53 (9). pp. 2209-2210. ISSN 0028-3878

Ocular Motility Disorders

Golding, C. V. P. and Danchaivijitr, C. and Hodgson, T. L. and Tabrizi, S. J. and Kennard, C. (2006) Identification of an oculomotor biomarker of preclinical Huntington disease. Neurology, 67 (3). pp. 485-487. ISSN 0028-3878

Oligonucleotides

Bethge, Lucas and Singh, Ishwar and Seitz, Oliver (2010) Designed thiazole orange nucleotides for the synthesis of single labelled oligonucleotides that fluoresce upon matched hybridization. Organic and Biomolecular Chemistry, 8 (10). pp. 2439-2448. ISSN 1477-0520

Singh, Ishwar and Freeman, Colin and Heaney, Frances (2011) Efficient synthesis of DNA conjugates by strain-promoted azide-cyclooctyne cycloaddition in the solid phase. European Journal of Organic Chemistry (33). pp. 6739-6746. ISSN 1434-193X

Singh, Ishwar and Vyle, Joseph S. and Heaney, Frances (2009) Fast, copper-free click chemistry: a convenient solid-phase approach to oligonucleotide conjugation. Chemical Communications, 45 (22). pp. 3276-3278. ISSN 1359-7345

Oligoribonucleotides

Singh, Ishwar and Heaney, Frances (2010) Metal free, "click and click-click'' conjugation of ribonucleosides and 2'-OMe oligoribonucleotides on the solid phase. Organic and Biomolecular Chemistry, 8 (2). pp. 451-456. ISSN 1477-0520

Operating ranges

Soon, C. F. and Youseffi, M. and Blagden, N. and Lobo, S. B. and Javid, F. A. and Denyer, M. C. T. (2009) Interactions of cells with elastic cholesteryl liquid crystals. In: World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany.

Optimisation

Elie, Mathieu Pierre and Baron, Mark G. and Birkett, Jason W. (2012) Injection port silylation of γ-hydroxybutyrate and trans-hydroxycrotonic acid: Conditions optimisation and characterisation of the di-tert-butyldimethylsilyl derivatives by GC-MS. Analyst, 137 (1). p. 255. ISSN 0003-2654

Optimization

David, W. I. F. and Shankland, K. and Pulham, C. R. and Blagden, N. and Davey, R. J. and Song, M. (2005) Polymorphism in benzamide. Angewandte Chemie - International Edition, 44 (43). pp. 7032-7035. ISSN 1433-7851

Oxidative Phosphorylation

Bates, T. E and Loesch, A. and Burnstock, G. and Clark, J. B. (1995) Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver. Biochemical and biophysical research communications, 213 (3). pp. 896-900. ISSN 0006-291X

Oxidative Stress

Heales, S. J. and Davies, S. E. and Bates, T. E. and Clark, J. B. (1995) Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration. Neurochemical research, 20 (1). pp. 31-38. ISSN 0364-3190

PEG

Vllasaliu, Driton and Fowler, Robyn and Stolnik, Snjezana (2014) PEGylated nanomedicines: recent progress and remaining concerns. Expert Opinion on Drug Delivery, 11 (1). pp. 139-154. ISSN 1742-5247

PEG-g-chitosan

Casettari, Luca and Vllasaliu, Driton and Castagnino, Enzo and Stolnik, Snjezana and Howdle, Steven and Illum, Lisbeth (2012) PEGylated chitosan derivatives: synthesis, characterizations and pharmaceutical applications. Progress in Polymer Science, 37 (5). pp. 659-685. ISSN 0079-6700

PEGylated nanomedicines

Vllasaliu, Driton and Fowler, Robyn and Stolnik, Snjezana (2014) PEGylated nanomedicines: recent progress and remaining concerns. Expert Opinion on Drug Delivery, 11 (1). pp. 139-154. ISSN 1742-5247

PEGylation

Casettari, Luca and Vllasaliu, Driton and Castagnino, Enzo and Stolnik, Snjezana and Howdle, Steven and Illum, Lisbeth (2012) PEGylated chitosan derivatives: synthesis, characterizations and pharmaceutical applications. Progress in Polymer Science, 37 (5). pp. 659-685. ISSN 0079-6700

Parkinson's disease

Rosin, Claudia and Colombo, Sergio and Calver, Andrew A. and Bates, Timothy E. and Skaper, Stephen D. (2005) Dopamine D2 and D3 receptor agonists limit oligodendrocyte injury caused by glutamate oxidative stress and oxygen/glucose deprivation. Glia, 52 (4). pp. 336-343. ISSN 0894-1491

Particle morphology, Crystal engineering

Blagden, N. and de Matas, M. and Gavan, P.T. and York, P. (2007) Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Advanced Drug Delivery Reviews, 59 (7). pp. 617-630. ISSN 0169-409X

Permeability enhancement

Casettari, Luca and Vllasaliu, Driton and Mantovani, Guiseppe and Howdle, Steven M. and Stolnik, Snow and Illum, Lisbeth (2010) Effect of PEGylation on the toxicity and permeability enhancement of chitosan. Biomacromolecules, 11 (11). pp. 2854-2865. ISSN 1525-7797

Permeation enhancer

Vllasaliu, Driton and Exposito-Harris, Ruth and Heras, Angeles and Casettari, Luca and Garnett, Martin and Illum, Lisbeth and Stolnik, Snow (2010) Tight junction modulation by chitosan nanoparticles: comparison with chitosan solution. International Journal of Pharmaceutics, 400 (1-2). pp. 183-193. ISSN 0378-5173

Permeation enhancers

Vllasaliu, Driton and Shubber, Saif and Fowler, Robyn and Garnett, Martin and Alexander, Cameron and Stolnik, Snow (2013) Epithelial toxicity of alkylglycoside surfactants. Journal of Pharmaceutical Sciences, 102 (1). pp. 114-125. ISSN 0975-1459

Pharmaceutical Preparations

Blagden, N. and de Matas, M. and Gavan, P.T. and York, P. (2007) Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Advanced Drug Delivery Reviews, 59 (7). pp. 617-630. ISSN 0169-409X

Rose, Peter and Whiteman, Matt and Moore, Philip K. and Yi, Zhun Zhu (2005) Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents. Natural Product Reports, 22 (3). pp. 351-368. ISSN 0265-0568

Pharmacokinetics

Lappin, G. and Boyce, M. J. and Matzow, T. and Lociuro, S. and Seymour, M. and Warrington, S. J. (2013) A microdose study of 14C-AR-709 in healthy men: pharmacokinetics, absolute bioavailability and concentrations in key compartments of the lung. European Journal of Clinical Pharmacology, 69 (9). pp. 1673-1682. ISSN 0031-6970

Lappin, Graham (2011) Microdosing: pharmacokinetic and metabolism data early in the drug development process. In: Pharmacokinetics in drug development: advanves and applications. Pharmacokinetics in Drug Development (3). Springer, New York. ISBN 9781441979377

Lappin, Graham (2010) Pharmacokinetics II: 14C-labelled microdosing in assessing drug pharmacokinetics at phase-0. In: Clinical Pharmacology, Current Topics and Case Studies. Springer, pp. 155-165. ISBN 9783709101438

Pharmacy

Lappin, Graham and Tampion, J. and Stride, J. (1989) The biotransformation of monoterpenoids by tissue plant culture. In: Secondary metabolism in plant cell cultures. Cambridge University Press. ISBN UNSPECIFIED

Parmar, Virinder S. and Sharma, Nawal K. and Husain, Mofazzal and Watterson, Arthur C. and Kumar, Jayant and Samuelson, Lynne A. and Cholli, Ashok L. and Prasad, Ashok K. and Kumar, Ajay and Malhotra, Sanjay and Kumar, Naresh and Jha, Amitabh and Singh, Amarjit and Singh, Ishwar and Himanshu, and Vats, Archana and Shakil, Najam A. and Trikha, Smriti and Mukherjee, Shubasish and Sharma, Sunil K. and Singh, Sanjay K. and Kumar, Ajay and Jha, Hriday N. and Olsen, Carl E. and Stove, Chrisophe P. and Bracke, Marc E. and Mareel, Marc M. (2003) Synthesis, characterization and in vitro anti-invasive activity screening of polyphenolic and heterocyclic compounds. Bioorganic and Medicinal Chemistry, 11 (6). pp. 913-929. ISSN 0968-0896

Raj, Hanumantharao G. and Singh, Ishwar and Kohli, Ekta and Kumari, Ranju and Gupta, Garima and Tyagi, Yogesh K. and Kumar, Ajit and Prasad, Ashok K. and Kaushik, Narendra K. and Olsen, Carl E. and Watterson, Arthur C. and Parmar, Virinder S. (2003) Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part 10: Identification of inhibitors for the liver microsomal acetoxycoumarin: protein transacetylase. Bioorganic and Medicinal Chemistry , 11 (6). pp. 1015-1019. ISSN 0968-0896

Singh, Ishwar and Prasad, Ashok K. and Sharma, Ajendra K. and Saxena, Rajendra K. and Olsen, Carl E. and Cholli, Ashok L. and Samuelson, Lynne A. and Kumar, Jayant and Watterson, Arthur C. and Parmar, Virinder S. (2003) Synthetic and novel biocatalytic resolution studies on (+/-)-5/6/7-acetoxy-4-aryl-3,4-dihydrocoumarins. Bioorganic and Medicinal Chemistry, 11 (4). pp. 529-538. ISSN 0968-0896

Phase 0

Lappin, Graham and Garner, R. Colin (2004) Current perspectives of 14C-isotope measurement in biomedical accelerator mass spectrometry. Analytical and Bioanalytical Chemistry, 378 (2). pp. 356-364. ISSN 1618-2642

Phase Transition

Dematos, Luciana L. and Williams, Adrian C. and Booth, Steven W. and Petts, Catherine R. and Taylor, David J. and Blagden, Nicholas (2007) Solvent influences on metastable polymorph lifetimes: real-time interconversions using energy dispersive X-ray diffractometry. Journal of Pharmaceutical Sciences, 96 (5). pp. 1069-1078. ISSN 0022-3549

Phase transitions, Reaction kinetics

Davey, R. J. and Blagden, N. and Righini, S. and Alison, H. and Ferrari, E. S. (2002) Nucleation control in solution mediated polymorphic phase transformations: the case of 2,6-dihydroxybenzoic acid. Journal of Physical Chemistry B, 106 (8). pp. 1954-1959. ISSN 1520-6106

Phosphodiester

Murphy, Elizabeth J. and Bates, Timothy E. and Williams, Stephen R. and Watson, Tracey and Brindle, Kevin M. and Rajagopalan, Bheeshma and Radda, George K. (1992) Endoplasmic reticulum: the major contributor to the PDE peak in hepatic 31P-NMR spectra at low magnetic field strengths. Biochimica et biophysica acta: biomembranes, 1111 (1). pp. 51-58. ISSN 0005-2736

Phosphodiesters

Bates, Timothy E. and Williams, Stephen R. and Gadian, David G. (1989) Phosphodiesters in the liver: the effect of field strength on the 31P signal. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 12 (1). pp. 145-150. ISSN 0740-3194

Polymorphic modifications, Carboxylic acids

Davey, R. J. and Blagden, N. and Righini, S. and Alison, H. and Ferrari, E. S. (2002) Nucleation control in solution mediated polymorphic phase transformations: the case of 2,6-dihydroxybenzoic acid. Journal of Physical Chemistry B, 106 (8). pp. 1954-1959. ISSN 1520-6106

Polymorphism

Blagden, N. and de Matas, M. and Gavan, P.T. and York, P. (2007) Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Advanced Drug Delivery Reviews, 59 (7). pp. 617-630. ISSN 0169-409X

David, W. I. F. and Shankland, K. and Pulham, C. R. and Blagden, N. and Davey, R. J. and Song, M. (2005) Polymorphism in benzamide. Angewandte Chemie - International Edition, 44 (43). pp. 7032-7035. ISSN 1433-7851

Polymorphs

Blagden, Nicholas and Davey, R. (1999) Polymorphs take shape. Chemistry in Britain, 35 (3). pp. 44-45. ISSN 0009-3106

Polystyrene nanoparticles

Moradi, Emilia and Vllasaliu, Driton and Garnett, Martin and Falcone, Franco and Stolnik, Snow (2012) Ligand density and clustering effects on endocytosis of folate modified nanoparticles. RSC Advances, 2 (7). pp. 3025-3033. ISSN 2046-2069

Port

Elie, Mathieu Pierre and Baron, Mark G. and Birkett, Jason W. (2012) Injection port silylation of γ-hydroxybutyrate and trans-hydroxycrotonic acid: Conditions optimisation and characterisation of the di-tert-butyldimethylsilyl derivatives by GC-MS. Analyst, 137 (1). p. 255. ISSN 0003-2654

Proteins

Lappin, Graham and Garner, R. Colin (2004) Current perspectives of 14C-isotope measurement in biomedical accelerator mass spectrometry. Analytical and Bioanalytical Chemistry, 378 (2). pp. 356-364. ISSN 1618-2642

Soon, C. F. and Youseffi, M. and Blagden, N. and Lobo, S. B. and Javid, F. A. and Denyer, M. C. T. (2009) Interactions of cells with elastic cholesteryl liquid crystals. In: World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany.

Proton

Gadian, D. G. and Bates, T. E. and Williams, S. R. and Bell, J. D. and Austin, S. J. and Connelly, A. (1991) Approaches to editing, assignment and interpretation of proton spectra. NMR in biomedicine, 4 (2). pp. 85-89. ISSN 0952-3480

Qualitative analysis

Soon, C. F. and Youseffi, M. and Blagden, N. and Lobo, S. B. and Javid, F. A. and Denyer, M. C. T. (2009) Interactions of cells with elastic cholesteryl liquid crystals. In: World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany.

RNA

Singh, Ishwar and Freeman, Colin and Madder, Annemieke and Vyle, Joseph S. and Heaney, Frances (2012) Fast RNA conjugations on solid phase by strain-promoted cycloadditions. Organic and Biomolecular Chemistry, 10 (33). pp. 6633-6639. ISSN 1477-0520

Rat

van Ravenzwaay, B. and Hardwick, T. D. and Needham, D. and Pethen, S. and Lappin, G. J. (2003) Comparative metabolism of 2,4-dichlorophenoxyacetic acid (2,4-D) in rat and dog. Xenobiotica: the fate of foreign compounds in biological systems, 33 (8). pp. 805-21. ISSN 0049-8254

Redox

Davis, Carol and Gordon, Natasha and Murphy, Sinead and Singh, Ishwar and Kavanagh, Kevin and Carberry, Stephen and Doyle, Sean (2011) Single-pot derivatisation strategy for enhanced gliotoxin detection by HPLC and MALDI-ToF mass spectrometry. Analytical and Bioanalytical Chemistry, 401 (8). pp. 2519-2529. ISSN 1618-2642

Reduced toxicity

Casettari, Luca and Vllasaliu, Driton and Mantovani, Guiseppe and Howdle, Steven M. and Stolnik, Snow and Illum, Lisbeth (2010) Effect of PEGylation on the toxicity and permeability enhancement of chitosan. Biomacromolecules, 11 (11). pp. 2854-2865. ISSN 1525-7797

Reperfusion

Almeida, Angeles and Allen, Kathryn L. and Bates, TImothy E. and Clark, John B. (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. Journal of neurochemistry, 65 (4). pp. 1698-1703. ISSN 0022-3042

Reperfusion injury

Almeida, Angeles and Allen, Kathryn L. and Bates, TImothy E. and Clark, John B. (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. Journal of neurochemistry, 65 (4). pp. 1698-1703. ISSN 0022-3042

Respiratory chain

Almeida, Angeles and Allen, Kathryn L. and Bates, TImothy E. and Clark, John B. (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. Journal of neurochemistry, 65 (4). pp. 1698-1703. ISSN 0022-3042

Reverse Transcriptase Polymerase Chain Reaction

Williams, David R. and Chanos, P. (2012) Application of anti-listerial bacteriocins: monitoring enterocin expression by multiplex relative reverse transcription-PCR. Biochemical Society Transactions, 40 (6). pp. 1544-1548. ISSN 0300-5127

Ribonucleosides

Singh, Ishwar and Heaney, Frances (2010) Metal free, "click and click-click'' conjugation of ribonucleosides and 2'-OMe oligoribonucleotides on the solid phase. Organic and Biomolecular Chemistry, 8 (2). pp. 451-456. ISSN 1477-0520

SB366791

Athanasiou, Andriani and Smith, Paul A. and Vakilpour, Sara and Kumaran, Nethia M. and Turner, Amy E. and Bagiokou, Dimitra and Layfield, Robert and Ray, David E. and Westwell, Andrew D. and Alexander, Stephen P. H. and Kendall, David A. and Lobo, Dileep N. and Watson, Susan A. and Lophatanon, Artitaya and Muir, Kenneth A. and Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

SPAP reporter gene

Abdel-Razaq, W. and Bates, T. E. and Kendall, D. A. (2007) The effects of antidepressants on cyclic AMP-response element-driven gene transcription in a model cell system. Biochemical Pharmacology, 73 (12). pp. 1995-2003. ISSN 0006-2952

Saccades

Golding, C. V. P. and Danchaivijitr, C. and Hodgson, T. L. and Tabrizi, S. J. and Kennard, C. (2006) Identification of an oculomotor biomarker of preclinical Huntington disease. Neurology, 67 (3). pp. 485-487. ISSN 0028-3878

Scattering matrices

Soon, Chin Phong and Khaghani, Seyed Ali and Youseffi, Mansour and Nayan, Nafarizal and Saim, Hashim and Britland, Stephen and Blagden, Nicholas and Denyer, Morgan Clive Thomas (2013) Interfacial study of cell adhesion to liquid crystals using widefield surface plasmon resonance microscopy. Colloids and Surfaces B: Biointerfaces, 110 . pp. 156-162. ISSN 0927-7765

Scattering parameters

Soon, Chin Phong and Khaghani, Seyed Ali and Youseffi, Mansour and Nayan, Nafarizal and Saim, Hashim and Britland, Stephen and Blagden, Nicholas and Denyer, Morgan Clive Thomas (2013) Interfacial study of cell adhesion to liquid crystals using widefield surface plasmon resonance microscopy. Colloids and Surfaces B: Biointerfaces, 110 . pp. 156-162. ISSN 0927-7765

Sensors

Baron, M. G. and Elie, M. (2003) Temperature sensing using reversible thermochromic polymeric films. Sensors and Actuators, B: Chemical, 90 (1-3). pp. 271-275. ISSN 0925-4005

Shear deformation

Soon, C. F. and Youseffi, M. and Blagden, N. and Lobo, S. B. and Javid, F. A. and Denyer, M. C. T. (2009) Interactions of cells with elastic cholesteryl liquid crystals. In: World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany.

Shear rates, Adhesion

Soon, C. F. and Youseffi, M. and Blagden, N. and Lobo, S. B. and Javid, F. A. and Denyer, M. C. T. (2009) Interactions of cells with elastic cholesteryl liquid crystals. In: World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany.

Silylation

Elie, Mathieu Pierre and Baron, Mark G. and Birkett, Jason W. (2012) Injection port silylation of γ-hydroxybutyrate and trans-hydroxycrotonic acid: Conditions optimisation and characterisation of the di-tert-butyldimethylsilyl derivatives by GC-MS. Analyst, 137 (1). p. 255. ISSN 0003-2654

Skeletal Muscle

Bates, T. E. and Loesch, A. and Burnstock, G. and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochemical and biophysical research communications, 218 (1). pp. 40-44. ISSN 0006-291X

Solid-phase synthesis

Singh, Ishwar and Freeman, Colin and Heaney, Frances (2011) Efficient synthesis of DNA conjugates by strain-promoted azide-cyclooctyne cycloaddition in the solid phase. European Journal of Organic Chemistry (33). pp. 6739-6746. ISSN 1434-193X

Solubility

Blagden, N. and de Matas, M. and Gavan, P.T. and York, P. (2007) Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Advanced Drug Delivery Reviews, 59 (7). pp. 617-630. ISSN 0169-409X

Solvents

Ali, Hany S. M. and York, Peter and Blagden, Nicholas (2009) Preparation of hydrocortisone nanosuspension through a bottom-up nanoprecipitation technique using microfluidic reactors. International Journal of Pharmaceutics, 375 (1-2). pp. 107-113. ISSN 0378-5173

Blagden, N. and de Matas, M. and Gavan, P.T. and York, P. (2007) Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Advanced Drug Delivery Reviews, 59 (7). pp. 617-630. ISSN 0169-409X

Dematos, Luciana L. and Williams, Adrian C. and Booth, Steven W. and Petts, Catherine R. and Taylor, David J. and Blagden, Nicholas (2007) Solvent influences on metastable polymorph lifetimes: real-time interconversions using energy dispersive X-ray diffractometry. Journal of Pharmaceutical Sciences, 96 (5). pp. 1069-1078. ISSN 0022-3549

Sporidesmin A}

Davis, Carol and Gordon, Natasha and Murphy, Sinead and Singh, Ishwar and Kavanagh, Kevin and Carberry, Stephen and Doyle, Sean (2011) Single-pot derivatisation strategy for enhanced gliotoxin detection by HPLC and MALDI-ToF mass spectrometry. Analytical and Bioanalytical Chemistry, 401 (8). pp. 2519-2529. ISSN 1618-2642

Structure elucidation, Organic compounds

David, W. I. F. and Shankland, K. and Pulham, C. R. and Blagden, N. and Davey, R. J. and Song, M. (2005) Polymorphism in benzamide. Angewandte Chemie - International Edition, 44 (43). pp. 7032-7035. ISSN 1433-7851

Sulfoxides, Alliaceae

Rose, Peter and Whiteman, Matt and Moore, Philip K. and Yi, Zhun Zhu (2005) Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents. Natural Product Reports, 22 (3). pp. 351-368. ISSN 0265-0568

Sulfur compounds, Polymorphs, Powders, solvent

Blagden, Nicholas (2001) Crystal engineering of polymorph appearance: the case of sulphathiazole. Powder Technology, 121 (1). pp. 46-52. ISSN 0032-5910

Supersensitivity

Broadley, K. J. and Chess-Williams, R. G. and Grassby, P. F. (1986) A physiological basis for subclassifying beta-adrenoceptors examined by chemical sympathectomy of guinea-pigs. Journal of Physiology, 373 (1). pp. 367-378. ISSN 0022-3751

Broadley, K. J. and Williams, R. G. and Hawthorn, M. H. and Grassby, Paul (1984) Mechanisms of cardiac supersensitivity to sympathomimetic amines. Methods and Findings in Experimental and Clinical Pharmacology, 6 (4). pp. 179-186. ISSN 0379-0355

Supramolecular chemistry, Drug products, er 34122

Blagden, N. and de Matas, M. and Gavan, P.T. and York, P. (2007) Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Advanced Drug Delivery Reviews, 59 (7). pp. 617-630. ISSN 0169-409X

Surface modification

Vllasaliu, Driton and Alexander, Cameron and Garnett, Martin and Eaton , Mike and Stolnik, Snow (2012) Fc-mediated transport of nanoparticles across airway epithelial cell layers. Journal of Controlled Release, 158 (3). pp. 479-486. ISSN 0168-3659

Surface plasmon excitation

Soon, Chin Phong and Khaghani, Seyed Ali and Youseffi, Mansour and Nayan, Nafarizal and Saim, Hashim and Britland, Stephen and Blagden, Nicholas and Denyer, Morgan Clive Thomas (2013) Interfacial study of cell adhesion to liquid crystals using widefield surface plasmon resonance microscopy. Colloids and Surfaces B: Biointerfaces, 110 . pp. 156-162. ISSN 0927-7765

Surface plasmon resonance, Plasmons, vinculin, article

Soon, Chin Phong and Khaghani, Seyed Ali and Youseffi, Mansour and Nayan, Nafarizal and Saim, Hashim and Britland, Stephen and Blagden, Nicholas and Denyer, Morgan Clive Thomas (2013) Interfacial study of cell adhesion to liquid crystals using widefield surface plasmon resonance microscopy. Colloids and Surfaces B: Biointerfaces, 110 . pp. 156-162. ISSN 0927-7765

Surfactants

Vllasaliu, Driton and Shubber, Saif and Fowler, Robyn and Garnett, Martin and Alexander, Cameron and Stolnik, Snow (2013) Epithelial toxicity of alkylglycoside surfactants. Journal of Pharmaceutical Sciences, 102 (1). pp. 114-125. ISSN 0975-1459

Suspensions

Ali, Hany S. M. and York, Peter and Blagden, Nicholas (2009) Preparation of hydrocortisone nanosuspension through a bottom-up nanoprecipitation technique using microfluidic reactors. International Journal of Pharmaceutics, 375 (1-2). pp. 107-113. ISSN 0378-5173

Synaptosomal

Almeida, A. and Brooks, K. J. and Sammut, I. and Keelan, J. and Davey, G. P. and Clark, J. B. and Bates, T. E. (1995) Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain. Developmental Neuroscience, 17 (4). pp. 212-218. ISSN 0378-5866

Bates, T. E and Loesch, A. and Burnstock, G. and Clark, J. B. (1995) Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver. Biochemical and biophysical research communications, 213 (3). pp. 896-900. ISSN 0006-291X

Synaptosomes

Allen, Kathryn L. and Almeida, Angeles and Bates, Timothy E. and Clark, John B. (1995) Changes of respiratory chain activity in mitochondrial and synaptosomal fractions isolated from the gerbil brain after graded ischaemia. Journal of neurochemistry, 64 (5). pp. 2222-2229. ISSN 0022-3042

Synchrotrons

Dematos, Luciana L. and Williams, Adrian C. and Booth, Steven W. and Petts, Catherine R. and Taylor, David J. and Blagden, Nicholas (2007) Solvent influences on metastable polymorph lifetimes: real-time interconversions using energy dispersive X-ray diffractometry. Journal of Pharmaceutical Sciences, 96 (5). pp. 1069-1078. ISSN 0022-3549

Synthesis

Kumar, Ajay and Husain, Mofazzal and Prasad, Ashok K. and Singh, Iswar and Vats, Archana and Sharma, Nawal K. and Sharma, Sunil K. and Gupta, Rajinder K. and Olsen, Carl E. and Bracke, Marc E. and Gross, Richard A. and Parmar, Virinder S. (2003) Synthesis of novel heterocyclic compounds: routes to pyrazolyl 1,2,3-triazoles and their biological activity evaluation. Indian Journal of Chemistry : Section B, Oganic Chemistry including Medicinal Chemistry, 42 (8). pp. 1950-1957. ISSN 0376-4699

TASTPM

Pardon, Marie-Christine and Sarmad, Sarir and Rattray, Ivan and Bates, Timothy E. and Scullion, Gillian A. and Marsden, Charles A. and Barrett, David A. and Lowe, James and Kendall, David A. (2009) Repeated novel cage exposure-induced improvement of early Alzheimer's-like cognitive and amyloid changes in TASTPM mice is unrelated to changes in brain endocannabinoids levels. Neurobiology of Aging, 30 (7). pp. 1099-1113. ISSN 0197-4580

TBC

Elie, Mathieu Pierre and Baron, Mark G. and Birkett, Jason W. (2012) Injection port silylation of γ-hydroxybutyrate and trans-hydroxycrotonic acid: Conditions optimisation and characterisation of the di-tert-butyldimethylsilyl derivatives by GC-MS. Analyst, 137 (1). p. 255. ISSN 0003-2654

TEER

Vllasaliu, Driton and Shubber, Saif and Garnett, Martin and Alexander, Cameron and Eaton, Mike and Stolnik, Snow (2012) Evaluation of calcium depletion as a strategy for enhancement of mucosal absorption of macromolecules. Biochemical and Biophysical Research Communications, 418 (1). pp. 128-133. ISSN 0006-291X

THC

Athanasiou, Andriani and Clarke, Anna B. and Turner, Amy E. and Kumaran, Nethia M. and Vakilpour, Sara and Smith, Paul A. and Bagiokou, Dimitra and Bradshaw, Tracey D. and Westwell, Andrew D. and Fang, Lin and Lobo, Dileep N. and Constantinescu, Cris S. and Calabrese, Vittorio and Loesch, Andrzej and Alexander, Stephen P. H. and Clothier, Richard H. and Kendall, David A. and Bates, Timothy E. (2007) Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications, 364 (1). pp. 131-137. ISSN 0006-291x

TRPV1

Athanasiou, Andriani and Smith, Paul A. and Vakilpour, Sara and Kumaran, Nethia M. and Turner, Amy E. and Bagiokou, Dimitra and Layfield, Robert and Ray, David E. and Westwell, Andrew D. and Alexander, Stephen P. H. and Kendall, David A. and Lobo, Dileep N. and Watson, Susan A. and Lophatanon, Artitaya and Muir, Kenneth A. and Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

Technology, Pharmaceutical

Dematos, Luciana L. and Williams, Adrian C. and Booth, Steven W. and Petts, Catherine R. and Taylor, David J. and Blagden, Nicholas (2007) Solvent influences on metastable polymorph lifetimes: real-time interconversions using energy dispersive X-ray diffractometry. Journal of Pharmaceutical Sciences, 96 (5). pp. 1069-1078. ISSN 0022-3549

Temperature

Dematos, Luciana L. and Williams, Adrian C. and Booth, Steven W. and Petts, Catherine R. and Taylor, David J. and Blagden, Nicholas (2007) Solvent influences on metastable polymorph lifetimes: real-time interconversions using energy dispersive X-ray diffractometry. Journal of Pharmaceutical Sciences, 96 (5). pp. 1069-1078. ISSN 0022-3549

Temperature measurement, Thermochromic polymeric films, Plastic films

Baron, M. G. and Elie, M. (2003) Temperature sensing using reversible thermochromic polymeric films. Sensors and Actuators, B: Chemical, 90 (1-3). pp. 271-275. ISSN 0925-4005

Tetradecylmaltoside

Vllasaliu, Driton and Shubber, Saif and Fowler, Robyn and Garnett, Martin and Alexander, Cameron and Stolnik, Snow (2013) Epithelial toxicity of alkylglycoside surfactants. Journal of Pharmaceutical Sciences, 102 (1). pp. 114-125. ISSN 0975-1459

Tight junction modulation

Vllasaliu, Driton and Exposito-Harris, Ruth and Heras, Angeles and Casettari, Luca and Garnett, Martin and Illum, Lisbeth and Stolnik, Snow (2010) Tight junction modulation by chitosan nanoparticles: comparison with chitosan solution. International Journal of Pharmaceutics, 400 (1-2). pp. 183-193. ISSN 0378-5173

Tight junctions

Casettari, Luca and Vllasaliu, Driton and Mantovani, Guiseppe and Howdle, Steven M. and Stolnik, Snow and Illum, Lisbeth (2010) Effect of PEGylation on the toxicity and permeability enhancement of chitosan. Biomacromolecules, 11 (11). pp. 2854-2865. ISSN 1525-7797

Vllasaliu, Driton and Casettari, Luca and Fowler, Robyn and Exposito-Harris, Ruth and Garnett, Martin and Illum, Lisbeth and Stolnik, Snow (2012) Absorption-promoting effects of chitosan in airway and intestinal cell lines: a comparative study. International Journal of Pharmaceutics, 430 (1-2). pp. 151-160. ISSN 0378-5173

Vllasaliu, Driton and Fowler, Robyn and Garnett, Martin and Eaton , Mike and Stolnik, Snow (2011) Barrier characteristics of epithelial cultures modelling the airway and intestinal mucosa: a comparison. Biochemical and Biophysical Research Communications, 415 (4). pp. 579-585. ISSN 0006-291X

Vllasaliu, Driton and Shubber, Saif and Garnett, Martin and Alexander, Cameron and Eaton, Mike and Stolnik, Snow (2012) Evaluation of calcium depletion as a strategy for enhancement of mucosal absorption of macromolecules. Biochemical and Biophysical Research Communications, 418 (1). pp. 128-133. ISSN 0006-291X

Time Factors

Dematos, Luciana L. and Williams, Adrian C. and Booth, Steven W. and Petts, Catherine R. and Taylor, David J. and Blagden, Nicholas (2007) Solvent influences on metastable polymorph lifetimes: real-time interconversions using energy dispersive X-ray diffractometry. Journal of Pharmaceutical Sciences, 96 (5). pp. 1069-1078. ISSN 0022-3549

Tissue engineering

Casettari, Luca and Vllasaliu, Driton and Lam, Jenny K. W. and Soliman, Mahmoud and Illum, Lisbeth (2012) Biomedical applications of amino acid-modified chitosans: a review. Biomaterials, 33 (30). pp. 7565-7583. ISSN 0142-9612

Tissue engineering, Cells

Soon, C. F. and Youseffi, M. and Blagden, N. and Lobo, S. B. and Javid, F. A. and Denyer, M. C. T. (2009) Interactions of cells with elastic cholesteryl liquid crystals. In: World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany.

Toxicity

Lappin, Graham and Garner, R. Colin (2004) Current perspectives of 14C-isotope measurement in biomedical accelerator mass spectrometry. Analytical and Bioanalytical Chemistry, 378 (2). pp. 356-364. ISSN 1618-2642

Toxicology

Vllasaliu, Driton and Shubber, Saif and Fowler, Robyn and Garnett, Martin and Alexander, Cameron and Stolnik, Snow (2013) Epithelial toxicity of alkylglycoside surfactants. Journal of Pharmaceutical Sciences, 102 (1). pp. 114-125. ISSN 0975-1459

Transepithelial electrical resistance

Casettari, Luca and Vllasaliu, Driton and Mantovani, Guiseppe and Howdle, Steven M. and Stolnik, Snow and Illum, Lisbeth (2010) Effect of PEGylation on the toxicity and permeability enhancement of chitosan. Biomacromolecules, 11 (11). pp. 2854-2865. ISSN 1525-7797

Treatment Outcome

Schon, F. and Hart, P. E. and Hodgson, T. L. and Pambakian, A. L. M. and Ruprah, M. and Williamson, E.M. and Kennard, C. (1999) Suppression of pendular nystagmus by smoking cannabis in a patient with multiple sclerosis. Neurology, 53 (9). pp. 2209-2210. ISSN 0028-3878

Tridecylmaltoside

Vllasaliu, Driton and Shubber, Saif and Fowler, Robyn and Garnett, Martin and Alexander, Cameron and Stolnik, Snow (2013) Epithelial toxicity of alkylglycoside surfactants. Journal of Pharmaceutical Sciences, 102 (1). pp. 114-125. ISSN 0975-1459

Tumors

Lappin, Graham and Garner, R. Colin (2004) Current perspectives of 14C-isotope measurement in biomedical accelerator mass spectrometry. Analytical and Bioanalytical Chemistry, 378 (2). pp. 356-364. ISSN 1618-2642

Ultrasensitive drug analysis, Carbon, Animalia

Lappin, Graham and Garner, R. Colin (2004) Current perspectives of 14C-isotope measurement in biomedical accelerator mass spectrometry. Analytical and Bioanalytical Chemistry, 378 (2). pp. 356-364. ISSN 1618-2642

Uptake inhibition

Broadley, Kenneth J. and Grassby, Paul F. (1985) Alpha- and beta-adrenoceptor-mediated responses of the guinea-pig ileum and the effects of neuronal uptake inhibition. Naunyn-Schmiedeberg's Archives of Pharmacology, 331 (4). pp. 316-323. ISSN 0028-1298

Van de Graaff accelerators, Accelerator mass spectrometry

Lappin, Graham and Garner, R. Colin (2004) Current perspectives of 14C-isotope measurement in biomedical accelerator mass spectrometry. Analytical and Bioanalytical Chemistry, 378 (2). pp. 356-364. ISSN 1618-2642

Vanilloid

Athanasiou, Andriani and Smith, Paul A. and Vakilpour, Sara and Kumaran, Nethia M. and Turner, Amy E. and Bagiokou, Dimitra and Layfield, Robert and Ray, David E. and Westwell, Andrew D. and Alexander, Stephen P. H. and Kendall, David A. and Lobo, Dileep N. and Watson, Susan A. and Lophatanon, Artitaya and Muir, Kenneth A. and Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

Vanilloids

Athanasiou, Andriani and Smith, Paul A. and Vakilpour, Sara and Kumaran, Nethia M. and Turner, Amy E. and Bagiokou, Dimitra and Layfield, Robert and Ray, David E. and Westwell, Andrew D. and Alexander, Stephen P. H. and Kendall, David A. and Lobo, Dileep N. and Watson, Susan A. and Lophatanon, Artitaya and Muir, Kenneth A. and Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

Veterinary Antivirals

Field, Hugh J. and Biswas, Subhajit and Mohammad, Islam T. (2006) Herpesvirus latency and therapy--from a veterinary perspective. Antiviral Research, 71 (2-3). pp. 127-133. ISSN 0166-3542

Virology

Field, Hugh J. and Biswas, Subhajit and Mohammad, Islam T. (2006) Herpesvirus latency and therapy--from a veterinary perspective. Antiviral Research, 71 (2-3). pp. 127-133. ISSN 0166-3542

Water

Dematos, Luciana L. and Williams, Adrian C. and Booth, Steven W. and Petts, Catherine R. and Taylor, David J. and Blagden, Nicholas (2007) Solvent influences on metastable polymorph lifetimes: real-time interconversions using energy dispersive X-ray diffractometry. Journal of Pharmaceutical Sciences, 96 (5). pp. 1069-1078. ISSN 0022-3549

Watercress

Rose, Peter and Faulkner, Kathy and Williamson, Gary and Mithen, Gary (2000) 7-Methylsulfinylheptyl and 8-methylsulfinyloctyl isothiocyanates from watercress are potent inducers of phase II enzymes. Carcinogenesis, 21 (11). pp. 1983-1988. ISSN 0143-3334

Wide-field, Cell adhesion

Soon, Chin Phong and Khaghani, Seyed Ali and Youseffi, Mansour and Nayan, Nafarizal and Saim, Hashim and Britland, Stephen and Blagden, Nicholas and Denyer, Morgan Clive Thomas (2013) Interfacial study of cell adhesion to liquid crystals using widefield surface plasmon resonance microscopy. Colloids and Surfaces B: Biointerfaces, 110 . pp. 156-162. ISSN 0927-7765

X ray analysis

Ali, Hany S. M. and York, Peter and Blagden, Nicholas (2009) Preparation of hydrocortisone nanosuspension through a bottom-up nanoprecipitation technique using microfluidic reactors. International Journal of Pharmaceutics, 375 (1-2). pp. 107-113. ISSN 0378-5173

X ray diffraction, 2-Propanol

Dematos, Luciana L. and Williams, Adrian C. and Booth, Steven W. and Petts, Catherine R. and Taylor, David J. and Blagden, Nicholas (2007) Solvent influences on metastable polymorph lifetimes: real-time interconversions using energy dispersive X-ray diffractometry. Journal of Pharmaceutical Sciences, 96 (5). pp. 1069-1078. ISSN 0022-3549

X ray powder diffraction

Ali, Hany S. M. and York, Peter and Blagden, Nicholas (2009) Preparation of hydrocortisone nanosuspension through a bottom-up nanoprecipitation technique using microfluidic reactors. International Journal of Pharmaceutics, 375 (1-2). pp. 107-113. ISSN 0378-5173

X ray powder diffraction, Benzamide

David, W. I. F. and Shankland, K. and Pulham, C. R. and Blagden, N. and Davey, R. J. and Song, M. (2005) Polymorphism in benzamide. Angewandte Chemie - International Edition, 44 (43). pp. 7032-7035. ISSN 1433-7851

X-ray diffraction

Seaton, Colin C. and Blagden, Nicholas and Munshi, Tasnim and Scowen, Ian J. (2013) Creation of ternary multicomponent crystals by exploitation of charge-transfer interactions. Chemistry - A European Journal, 19 (32). pp. 10663-10671. ISSN 0947-6539

Xanthone

Madan, Babita and Singh, Ishwar and Kumar, Ajit and Prasad, Ashok K. and Raj, Hanumantharao G. and Parmar, Virinder S. and Ghosh, Balaram (2002) Xanthones as inhibitors of microsomal lipid peroxidation and TNF-alpha induced ICAM-1 expression on human umbilical vein endothelial cells (HUVECs). Bioorganic and Medicinal Chemistry, 10 (11). pp. 3431-3436. ISSN 0968-0896

abasic site

Beuck, C and Singh, I. and Bhattacharya, A and Heckler, W and Parmar, VS and Seitz, O and Weinhold, E (2003) Polycyclic aromatic DNA-Base surrogates: high-affinity binding to an adenine-specific base-flipping DNA methyltransferase. Angewandte Chemie International Edition, 42 (33). pp. 3958-3960. ISSN 1433-7851

acetyl-L-carnitine

Mancuso, Cesare and Bates, Timothy E. and Butterfield, D. Allan and Calafato, Stella and Cornelius, Carolin and De Lorenzo, Antonino and Dinkova Kostova, Albena T. and Calabrese, Vittorio (2007) Natural antioxidants in Alzheimer's disease. Expert Opinion on Investigational Drugs, 16 (12). pp. 1921-1931. ISSN 1354-3784

acute liver failure

Bates, T. E. and Williams, S. R. and Busza, A. L. and Gadian, D. G. and Proctor, E. (1988) A 31P nuclear magnetic resonance study in vivo of metabolic abnormalities in rats with acute liver failure. NMR in biomedicine, 1 (2). pp. 67-73. ISSN 0952-3480

adult

Golding, C. V. P. and Danchaivijitr, C. and Hodgson, T. L. and Tabrizi, S. J. and Kennard, C. (2006) Identification of an oculomotor biomarker of preclinical Huntington disease. Neurology, 67 (3). pp. 485-487. ISSN 0028-3878

alliin lyase

Rose, Peter and Whiteman, Matt and Moore, Philip K. and Yi, Zhun Zhu (2005) Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents. Natural Product Reports, 22 (3). pp. 351-368. ISSN 0265-0568

alpha 1 adrenergic receptor blocking agent

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

amyloid precursor protein

Pardon, Marie-Christine and Sarmad, Sarir and Rattray, Ivan and Bates, Timothy E. and Scullion, Gillian A. and Marsden, Charles A. and Barrett, David A. and Lowe, James and Kendall, David A. (2009) Repeated novel cage exposure-induced improvement of early Alzheimer's-like cognitive and amyloid changes in TASTPM mice is unrelated to changes in brain endocannabinoids levels. Neurobiology of Aging, 30 (7). pp. 1099-1113. ISSN 0197-4580

anandamide

Athanasiou, Andriani and Clarke, Anna B. and Turner, Amy E. and Kumaran, Nethia M. and Vakilpour, Sara and Smith, Paul A. and Bagiokou, Dimitra and Bradshaw, Tracey D. and Westwell, Andrew D. and Fang, Lin and Lobo, Dileep N. and Constantinescu, Cris S. and Calabrese, Vittorio and Loesch, Andrzej and Alexander, Stephen P. H. and Clothier, Richard H. and Kendall, David A. and Bates, Timothy E. (2007) Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications, 364 (1). pp. 131-137. ISSN 0006-291x

anticancer

Daley, E. and Wilkie, D. and Loesch, A. and Hargreaves, I. P. and Kendall, D. A. and Pilkington, G. J. and Bates, T. E. (2005) Chlorimipramine: a novel anticancer agent with a mitochondrial target. Biochemical and Biophysical Research Communications, 328 (2). pp. 623-632. ISSN 0006-291X

antidepressants

Abdel-Razaq, W. and Bates, T. E. and Kendall, D. A. (2007) The effects of antidepressants on cyclic AMP-response element-driven gene transcription in a model cell system. Biochemical Pharmacology, 73 (12). pp. 1995-2003. ISSN 0006-2952

Daley, E. and Wilkie, D. and Loesch, A. and Hargreaves, I. P. and Kendall, D. A. and Pilkington, G. J. and Bates, T. E. (2005) Chlorimipramine: a novel anticancer agent with a mitochondrial target. Biochemical and Biophysical Research Communications, 328 (2). pp. 623-632. ISSN 0006-291X

antiestrogen

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

apoptosis

Athanasiou, Andriani and Clarke, Anna B. and Turner, Amy E. and Kumaran, Nethia M. and Vakilpour, Sara and Smith, Paul A. and Bagiokou, Dimitra and Bradshaw, Tracey D. and Westwell, Andrew D. and Fang, Lin and Lobo, Dileep N. and Constantinescu, Cris S. and Calabrese, Vittorio and Loesch, Andrzej and Alexander, Stephen P. H. and Clothier, Richard H. and Kendall, David A. and Bates, Timothy E. (2007) Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications, 364 (1). pp. 131-137. ISSN 0006-291x

Athanasiou, Andriani and Smith, Paul A. and Vakilpour, Sara and Kumaran, Nethia M. and Turner, Amy E. and Bagiokou, Dimitra and Layfield, Robert and Ray, David E. and Westwell, Andrew D. and Alexander, Stephen P. H. and Kendall, David A. and Lobo, Dileep N. and Watson, Susan A. and Lophatanon, Artitaya and Muir, Kenneth A. and Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

Daley, E. and Wilkie, D. and Loesch, A. and Hargreaves, I. P. and Kendall, D. A. and Pilkington, G. J. and Bates, T. E. (2005) Chlorimipramine: a novel anticancer agent with a mitochondrial target. Biochemical and Biophysical Research Communications, 328 (2). pp. 623-632. ISSN 0006-291X

area under the curve

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

article

Blagden, N. and Davey, R. J. and Rowe, R. and Roberts, R. (1998) Disappearing polymorphs and the role of reaction by-products: the case of sulphathiazole. International Journal of Pharmaceutics, 172 (1-2). pp. 169-177. ISSN 0378-5173

Golding, C. V. P. and Danchaivijitr, C. and Hodgson, T. L. and Tabrizi, S. J. and Kennard, C. (2006) Identification of an oculomotor biomarker of preclinical Huntington disease. Neurology, 67 (3). pp. 485-487. ISSN 0028-3878

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Schon, F. and Hart, P. E. and Hodgson, T. L. and Pambakian, A. L. M. and Ruprah, M. and Williamson, E.M. and Kennard, C. (1999) Suppression of pendular nystagmus by smoking cannabis in a patient with multiple sclerosis. Neurology, 53 (9). pp. 2209-2210. ISSN 0028-3878

atenolol

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

bacteriocin

Williams, David R. and Chanos, P. (2012) Application of anti-listerial bacteriocins: monitoring enterocin expression by multiplex relative reverse transcription-PCR. Biochemical Society Transactions, 40 (6). pp. 1544-1548. ISSN 0300-5127

beta-adrenoceptors

Broadley, K. J. and Chess-Williams, R. G. and Grassby, P. F. (1986) A physiological basis for subclassifying beta-adrenoceptors examined by chemical sympathectomy of guinea-pigs. Journal of Physiology, 373 (1). pp. 367-378. ISSN 0022-3751

bioengineering

Blagden, N. and de Matas, M. and Gavan, P.T. and York, P. (2007) Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Advanced Drug Delivery Reviews, 59 (7). pp. 617-630. ISSN 0169-409X

bipolar disorder

Kirkham, Emma and Bazire, Stephen and Anderson, Timothy and Wood, John and Grassby, Paul and Desborough, James (2013) Impact of active monitoring on lithium management in Norfolk. Therapeutic Advances in Psychopharmacology, 3 (5). pp. 260-265. ISSN 2045-1253

bmjindex

Seaton, Colin C. and Blagden, Nicholas and Munshi, Tasnim and Scowen, Ian J. (2013) Creation of ternary multicomponent crystals by exploitation of charge-transfer interactions. Chemistry - A European Journal, 19 (32). pp. 10663-10671. ISSN 0947-6539

brain

Almeida, A. and Brooks, K. J. and Sammut, I. and Keelan, J. and Davey, G. P. and Clark, J. B. and Bates, T. E. (1995) Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain. Developmental Neuroscience, 17 (4). pp. 212-218. ISSN 0378-5866

Almeida, Angeles and Allen, Kathryn L. and Bates, TImothy E. and Clark, John B. (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. Journal of neurochemistry, 65 (4). pp. 1698-1703. ISSN 0022-3042

Bates, T E and Almeida, A and Heales, S J and Clark, J B (1994) Postnatal development of the complexes of the electron transport chain in isolated rat brain mitochondria. Developmental neuroscience, 16 (5-6). pp. 321-7. ISSN 0378-5866

brain slices

Brooks, K. J. and Kauppinen, R. A. and Williams, S. R. and Bachelard, H. S. and Bates, T. E. and Gadian, D. G. (1989) Ammonia causes a drop in intracellular pH in metabolizing cortical brain slices. A [31P]- and [1H]nuclear magnetic resonance study. Neuroscience, 33 (1). pp. 185-192. ISSN 0306-4522

brain stem

Schon, F. and Hart, P. E. and Hodgson, T. L. and Pambakian, A. L. M. and Ruprah, M. and Williamson, E.M. and Kennard, C. (1999) Suppression of pendular nystagmus by smoking cannabis in a patient with multiple sclerosis. Neurology, 53 (9). pp. 2209-2210. ISSN 0028-3878

caffeine

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

cancer

Athanasiou, Andriani and Smith, Paul A. and Vakilpour, Sara and Kumaran, Nethia M. and Turner, Amy E. and Bagiokou, Dimitra and Layfield, Robert and Ray, David E. and Westwell, Andrew D. and Alexander, Stephen P. H. and Kendall, David A. and Lobo, Dileep N. and Watson, Susan A. and Lophatanon, Artitaya and Muir, Kenneth A. and Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

Daley, E. and Wilkie, D. and Loesch, A. and Hargreaves, I. P. and Kendall, D. A. and Pilkington, G. J. and Bates, T. E. (2005) Chlorimipramine: a novel anticancer agent with a mitochondrial target. Biochemical and Biophysical Research Communications, 328 (2). pp. 623-632. ISSN 0006-291X

cannabinoid

Athanasiou, Andriani and Clarke, Anna B. and Turner, Amy E. and Kumaran, Nethia M. and Vakilpour, Sara and Smith, Paul A. and Bagiokou, Dimitra and Bradshaw, Tracey D. and Westwell, Andrew D. and Fang, Lin and Lobo, Dileep N. and Constantinescu, Cris S. and Calabrese, Vittorio and Loesch, Andrzej and Alexander, Stephen P. H. and Clothier, Richard H. and Kendall, David A. and Bates, Timothy E. (2007) Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications, 364 (1). pp. 131-137. ISSN 0006-291x

cannabis, adult

Schon, F. and Hart, P. E. and Hodgson, T. L. and Pambakian, A. L. M. and Ruprah, M. and Williamson, E.M. and Kennard, C. (1999) Suppression of pendular nystagmus by smoking cannabis in a patient with multiple sclerosis. Neurology, 53 (9). pp. 2209-2210. ISSN 0028-3878

capsazepine

Athanasiou, Andriani and Smith, Paul A. and Vakilpour, Sara and Kumaran, Nethia M. and Turner, Amy E. and Bagiokou, Dimitra and Layfield, Robert and Ray, David E. and Westwell, Andrew D. and Alexander, Stephen P. H. and Kendall, David A. and Lobo, Dileep N. and Watson, Susan A. and Lophatanon, Artitaya and Muir, Kenneth A. and Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

carbamazepine

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

carbon 14

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

carbon tetrachloride

Bates, T. E. and Williams, S. R. and Busza, A. L. and Gadian, D. G. and Proctor, E. (1988) A 31P nuclear magnetic resonance study in vivo of metabolic abnormalities in rats with acute liver failure. NMR in biomedicine, 1 (2). pp. 67-73. ISSN 0952-3480

Bates, Timothy E. and Williams, Stephen R. and Kauppinen, Risto A. and Gadian, David G. (1989) Observation of cerebral metabolites in an animal model of acute liver failure in vivo: a 1H and 31P nuclear magnetic resonance study. Journal of neurochemistry, 53 (1). pp. 102-10. ISSN 0022-3042

case report

Schon, F. and Hart, P. E. and Hodgson, T. L. and Pambakian, A. L. M. and Ruprah, M. and Williamson, E.M. and Kennard, C. (1999) Suppression of pendular nystagmus by smoking cannabis in a patient with multiple sclerosis. Neurology, 53 (9). pp. 2209-2210. ISSN 0028-3878

celiprolol

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

cell adhesion

Soon, Chin Phong and Khaghani, Seyed Ali and Youseffi, Mansour and Nayan, Nafarizal and Saim, Hashim and Britland, Stephen and Blagden, Nicholas and Denyer, Morgan Clive Thomas (2013) Interfacial study of cell adhesion to liquid crystals using widefield surface plasmon resonance microscopy. Colloids and Surfaces B: Biointerfaces, 110 . pp. 156-162. ISSN 0927-7765

cell interaction

Soon, Chin Phong and Khaghani, Seyed Ali and Youseffi, Mansour and Nayan, Nafarizal and Saim, Hashim and Britland, Stephen and Blagden, Nicholas and Denyer, Morgan Clive Thomas (2013) Interfacial study of cell adhesion to liquid crystals using widefield surface plasmon resonance microscopy. Colloids and Surfaces B: Biointerfaces, 110 . pp. 156-162. ISSN 0927-7765

cell surface

Soon, Chin Phong and Khaghani, Seyed Ali and Youseffi, Mansour and Nayan, Nafarizal and Saim, Hashim and Britland, Stephen and Blagden, Nicholas and Denyer, Morgan Clive Thomas (2013) Interfacial study of cell adhesion to liquid crystals using widefield surface plasmon resonance microscopy. Colloids and Surfaces B: Biointerfaces, 110 . pp. 156-162. ISSN 0927-7765

cellular distribution

Soon, Chin Phong and Khaghani, Seyed Ali and Youseffi, Mansour and Nayan, Nafarizal and Saim, Hashim and Britland, Stephen and Blagden, Nicholas and Denyer, Morgan Clive Thomas (2013) Interfacial study of cell adhesion to liquid crystals using widefield surface plasmon resonance microscopy. Colloids and Surfaces B: Biointerfaces, 110 . pp. 156-162. ISSN 0927-7765

cellular stress

Calabrese, Vittorio and Bates, Timothy E. and Mancuso, Cesare and Cornelius, Carolin and Ventimiglia, Bernardo and Cambria, Maria Teresa and Di Renzo, Laura and De Lorenzo, Antonino and Dinkova-Kostova, Albena T. (2008) Curcumin and the cellular stress response in free radical-related diseases. Molecular Nutrition & Food Research, 52 (9). pp. 1062-1073. ISSN 1613-4125

cerebral ischaemia

Almeida, Angeles and Allen, Kathryn L. and Bates, TImothy E. and Clark, John B. (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. Journal of neurochemistry, 65 (4). pp. 1698-1703. ISSN 0022-3042

cerebral ischemia

Almeida, Angeles and Allen, Kathryn L. and Bates, TImothy E. and Clark, John B. (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. Journal of neurochemistry, 65 (4). pp. 1698-1703. ISSN 0022-3042

chemical modification

Blagden, Nicholas and Cross, Wendy I. and Davey, Roger J. and Broderick, Mairead and Pritchard, Robin G. and Roberts, Ronald J. and Rowe, Raymond C. (2001) Can crystal structure prediction be used as part of an integrated strategy for ensuring maximum diversity of isolated crystal forms? The case of 2-amino-4-nitrophenol. Physical Chemistry Chemical Physics, 3 (17). pp. 3819-3825. ISSN 1463-9076

chemical phenomena

Soon, Chin Phong and Khaghani, Seyed Ali and Youseffi, Mansour and Nayan, Nafarizal and Saim, Hashim and Britland, Stephen and Blagden, Nicholas and Denyer, Morgan Clive Thomas (2013) Interfacial study of cell adhesion to liquid crystals using widefield surface plasmon resonance microscopy. Colloids and Surfaces B: Biointerfaces, 110 . pp. 156-162. ISSN 0927-7765

chemical reaction

Blagden, Nicholas (2001) Crystal engineering of polymorph appearance: the case of sulphathiazole. Powder Technology, 121 (1). pp. 46-52. ISSN 0032-5910

chemical structure

Rose, Peter and Whiteman, Matt and Moore, Philip K. and Yi, Zhun Zhu (2005) Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents. Natural Product Reports, 22 (3). pp. 351-368. ISSN 0265-0568

chemistry

Rose, Peter and Whiteman, Matt and Moore, Philip K. and Yi, Zhun Zhu (2005) Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents. Natural Product Reports, 22 (3). pp. 351-368. ISSN 0265-0568

chitosan

Vllasaliu, Driton and Casettari, Luca and Bonacucina, Giulia and Cespi, Marco and Filippo Palmieri, Giovanni and Illum, Lisbeth (2013) Folic acid conjugated chitosan nanoparticles for tumor targeting of therapeutic and imaging agents. Pharmaceutical Nanotechnology, 1 (3). pp. 184-203. ISSN 2211-7385

chlorimipramine

Daley, E. and Wilkie, D. and Loesch, A. and Hargreaves, I. P. and Kendall, D. A. and Pilkington, G. J. and Bates, T. E. (2005) Chlorimipramine: a novel anticancer agent with a mitochondrial target. Biochemical and Biophysical Research Communications, 328 (2). pp. 623-632. ISSN 0006-291X

clarithromycin

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

clinical article

Golding, C. V. P. and Danchaivijitr, C. and Hodgson, T. L. and Tabrizi, S. J. and Kennard, C. (2006) Identification of an oculomotor biomarker of preclinical Huntington disease. Neurology, 67 (3). pp. 485-487. ISSN 0028-3878

clinical trial

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

clomipramine

Daley, E. and Wilkie, D. and Loesch, A. and Hargreaves, I. P. and Kendall, D. A. and Pilkington, G. J. and Bates, T. E. (2005) Chlorimipramine: a novel anticancer agent with a mitochondrial target. Biochemical and Biophysical Research Communications, 328 (2). pp. 623-632. ISSN 0006-291X

complexexs

Almeida, Angeles and Allen, Kathryn L. and Bates, TImothy E. and Clark, John B. (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. Journal of neurochemistry, 65 (4). pp. 1698-1703. ISSN 0022-3042

computer simulation

Soon, Chin Phong and Khaghani, Seyed Ali and Youseffi, Mansour and Nayan, Nafarizal and Saim, Hashim and Britland, Stephen and Blagden, Nicholas and Denyer, Morgan Clive Thomas (2013) Interfacial study of cell adhesion to liquid crystals using widefield surface plasmon resonance microscopy. Colloids and Surfaces B: Biointerfaces, 110 . pp. 156-162. ISSN 0927-7765

conference paper

Blagden, Nicholas (2001) Crystal engineering of polymorph appearance: the case of sulphathiazole. Powder Technology, 121 (1). pp. 46-52. ISSN 0032-5910

Williams, David R. and Chanos, P. (2012) Application of anti-listerial bacteriocins: monitoring enterocin expression by multiplex relative reverse transcription-PCR. Biochemical Society Transactions, 40 (6). pp. 1544-1548. ISSN 0300-5127

controlled clinical trial

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

controlled study

Golding, C. V. P. and Danchaivijitr, C. and Hodgson, T. L. and Tabrizi, S. J. and Kennard, C. (2006) Identification of an oculomotor biomarker of preclinical Huntington disease. Neurology, 67 (3). pp. 485-487. ISSN 0028-3878

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Soon, Chin Phong and Khaghani, Seyed Ali and Youseffi, Mansour and Nayan, Nafarizal and Saim, Hashim and Britland, Stephen and Blagden, Nicholas and Denyer, Morgan Clive Thomas (2013) Interfacial study of cell adhesion to liquid crystals using widefield surface plasmon resonance microscopy. Colloids and Surfaces B: Biointerfaces, 110 . pp. 156-162. ISSN 0927-7765

cornea reflex

Golding, C. V. P. and Danchaivijitr, C. and Hodgson, T. L. and Tabrizi, S. J. and Kennard, C. (2006) Identification of an oculomotor biomarker of preclinical Huntington disease. Neurology, 67 (3). pp. 485-487. ISSN 0028-3878

cross linking

Dematos, Luciana L. and Williams, Adrian C. and Booth, Steven W. and Petts, Catherine R. and Taylor, David J. and Blagden, Nicholas (2007) Solvent influences on metastable polymorph lifetimes: real-time interconversions using energy dispersive X-ray diffractometry. Journal of Pharmaceutical Sciences, 96 (5). pp. 1069-1078. ISSN 0022-3549

crystal

Blagden, N. and de Matas, M. and Gavan, P.T. and York, P. (2007) Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Advanced Drug Delivery Reviews, 59 (7). pp. 617-630. ISSN 0169-409X

crystal structure

Blagden, N. and Davey, R. J. and Rowe, R. and Roberts, R. (1998) Disappearing polymorphs and the role of reaction by-products: the case of sulphathiazole. International Journal of Pharmaceutics, 172 (1-2). pp. 169-177. ISSN 0378-5173

Blagden, N. and de Matas, M. and Gavan, P.T. and York, P. (2007) Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Advanced Drug Delivery Reviews, 59 (7). pp. 617-630. ISSN 0169-409X

Blagden, Nicholas (2001) Crystal engineering of polymorph appearance: the case of sulphathiazole. Powder Technology, 121 (1). pp. 46-52. ISSN 0032-5910

Blagden, Nicholas and Cross, Wendy I. and Davey, Roger J. and Broderick, Mairead and Pritchard, Robin G. and Roberts, Ronald J. and Rowe, Raymond C. (2001) Can crystal structure prediction be used as part of an integrated strategy for ensuring maximum diversity of isolated crystal forms? The case of 2-amino-4-nitrophenol. Physical Chemistry Chemical Physics, 3 (17). pp. 3819-3825. ISSN 1463-9076

crystallization

Blagden, Nicholas (2001) Crystal engineering of polymorph appearance: the case of sulphathiazole. Powder Technology, 121 (1). pp. 46-52. ISSN 0032-5910

Blagden, Nicholas and Cross, Wendy I. and Davey, Roger J. and Broderick, Mairead and Pritchard, Robin G. and Roberts, Ronald J. and Rowe, Raymond C. (2001) Can crystal structure prediction be used as part of an integrated strategy for ensuring maximum diversity of isolated crystal forms? The case of 2-amino-4-nitrophenol. Physical Chemistry Chemical Physics, 3 (17). pp. 3819-3825. ISSN 1463-9076

Dematos, Luciana L. and Williams, Adrian C. and Booth, Steven W. and Petts, Catherine R. and Taylor, David J. and Blagden, Nicholas (2007) Solvent influences on metastable polymorph lifetimes: real-time interconversions using energy dispersive X-ray diffractometry. Journal of Pharmaceutical Sciences, 96 (5). pp. 1069-1078. ISSN 0022-3549

crystallography

Blagden, Nicholas and Cross, Wendy I. and Davey, Roger J. and Broderick, Mairead and Pritchard, Robin G. and Roberts, Ronald J. and Rowe, Raymond C. (2001) Can crystal structure prediction be used as part of an integrated strategy for ensuring maximum diversity of isolated crystal forms? The case of 2-amino-4-nitrophenol. Physical Chemistry Chemical Physics, 3 (17). pp. 3819-3825. ISSN 1463-9076

Davey, R. J. and Blagden, N. and Potts, G. D. and Docherty, R. (1997) Polymorphism in molecular crystals: stabilization of a metastable form by conformational mimicry. Journal of the American Chemical Society, 119 (7). pp. 1767-1772. ISSN 0002-7863

culture technique

Soon, Chin Phong and Khaghani, Seyed Ali and Youseffi, Mansour and Nayan, Nafarizal and Saim, Hashim and Britland, Stephen and Blagden, Nicholas and Denyer, Morgan Clive Thomas (2013) Interfacial study of cell adhesion to liquid crystals using widefield surface plasmon resonance microscopy. Colloids and Surfaces B: Biointerfaces, 110 . pp. 156-162. ISSN 0927-7765

curcumin

Calabrese, Vittorio and Bates, Timothy E. and Mancuso, Cesare and Cornelius, Carolin and Ventimiglia, Bernardo and Cambria, Maria Teresa and Di Renzo, Laura and De Lorenzo, Antonino and Dinkova-Kostova, Albena T. (2008) Curcumin and the cellular stress response in free radical-related diseases. Molecular Nutrition & Food Research, 52 (9). pp. 1062-1073. ISSN 1613-4125

Mancuso, Cesare and Bates, Timothy E. and Butterfield, D. Allan and Calafato, Stella and Cornelius, Carolin and De Lorenzo, Antonino and Dinkova Kostova, Albena T. and Calabrese, Vittorio (2007) Natural antioxidants in Alzheimer's disease. Expert Opinion on Investigational Drugs, 16 (12). pp. 1921-1931. ISSN 1354-3784

cyclic-AMP

Abdel-Razaq, W. and Bates, T. E. and Kendall, D. A. (2007) The effects of antidepressants on cyclic AMP-response element-driven gene transcription in a model cell system. Biochemical Pharmacology, 73 (12). pp. 1995-2003. ISSN 0006-2952

cysteine

Rose, Peter and Whiteman, Matt and Moore, Philip K. and Yi, Zhun Zhu (2005) Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents. Natural Product Reports, 22 (3). pp. 351-368. ISSN 0265-0568

cytochrome P450 3A4

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

data analysis

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

databases

Kirkham, Emma and Bazire, Stephen and Anderson, Timothy and Wood, John and Grassby, Paul and Desborough, James (2013) Impact of active monitoring on lithium management in Norfolk. Therapeutic Advances in Psychopharmacology, 3 (5). pp. 260-265. ISSN 2045-1253

development

Almeida, A. and Brooks, K. J. and Sammut, I. and Keelan, J. and Davey, G. P. and Clark, J. B. and Bates, T. E. (1995) Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain. Developmental Neuroscience, 17 (4). pp. 212-218. ISSN 0378-5866

Bates, T E and Almeida, A and Heales, S J and Clark, J B (1994) Postnatal development of the complexes of the electron transport chain in isolated rat brain mitochondria. Developmental neuroscience, 16 (5-6). pp. 321-7. ISSN 0378-5866

diagnostic and therapeutic imaging

Vllasaliu, Driton and Casettari, Luca and Bonacucina, Giulia and Cespi, Marco and Filippo Palmieri, Giovanni and Illum, Lisbeth (2013) Folic acid conjugated chitosan nanoparticles for tumor targeting of therapeutic and imaging agents. Pharmaceutical Nanotechnology, 1 (3). pp. 184-203. ISSN 2211-7385

diazepam

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

differential scanning calorimetry

Ali, Hany S. M. and York, Peter and Blagden, Nicholas (2009) Preparation of hydrocortisone nanosuspension through a bottom-up nanoprecipitation technique using microfluidic reactors. International Journal of Pharmaceutics, 375 (1-2). pp. 107-113. ISSN 0378-5173

digoxin

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

diphenhydramine

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

disease course

Golding, C. V. P. and Danchaivijitr, C. and Hodgson, T. L. and Tabrizi, S. J. and Kennard, C. (2006) Identification of an oculomotor biomarker of preclinical Huntington disease. Neurology, 67 (3). pp. 485-487. ISSN 0028-3878

dopamine

Rosin, Claudia and Colombo, Sergio and Calver, Andrew A. and Bates, Timothy E. and Skaper, Stephen D. (2005) Dopamine D2 and D3 receptor agonists limit oligodendrocyte injury caused by glutamate oxidative stress and oxygen/glucose deprivation. Glia, 52 (4). pp. 336-343. ISSN 0894-1491

dopamine receptor

Rosin, Claudia and Colombo, Sergio and Calver, Andrew A. and Bates, Timothy E. and Skaper, Stephen D. (2005) Dopamine D2 and D3 receptor agonists limit oligodendrocyte injury caused by glutamate oxidative stress and oxygen/glucose deprivation. Glia, 52 (4). pp. 336-343. ISSN 0894-1491

dose calculation

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

dose response

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

dose time effect relation

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

drug

Rose, Peter and Whiteman, Matt and Moore, Philip K. and Yi, Zhun Zhu (2005) Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents. Natural Product Reports, 22 (3). pp. 351-368. ISSN 0265-0568

drug absorption

Blagden, N. and de Matas, M. and Gavan, P.T. and York, P. (2007) Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Advanced Drug Delivery Reviews, 59 (7). pp. 617-630. ISSN 0169-409X

drug activity

Schon, F. and Hart, P. E. and Hodgson, T. L. and Pambakian, A. L. M. and Ruprah, M. and Williamson, E.M. and Kennard, C. (1999) Suppression of pendular nystagmus by smoking cannabis in a patient with multiple sclerosis. Neurology, 53 (9). pp. 2209-2210. ISSN 0028-3878

drug and gene delivery

Vllasaliu, Driton and Casettari, Luca and Bonacucina, Giulia and Cespi, Marco and Filippo Palmieri, Giovanni and Illum, Lisbeth (2013) Folic acid conjugated chitosan nanoparticles for tumor targeting of therapeutic and imaging agents. Pharmaceutical Nanotechnology, 1 (3). pp. 184-203. ISSN 2211-7385

drug bioavailability

Blagden, N. and de Matas, M. and Gavan, P.T. and York, P. (2007) Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Advanced Drug Delivery Reviews, 59 (7). pp. 617-630. ISSN 0169-409X

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

drug blood level

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Schon, F. and Hart, P. E. and Hodgson, T. L. and Pambakian, A. L. M. and Ruprah, M. and Williamson, E.M. and Kennard, C. (1999) Suppression of pendular nystagmus by smoking cannabis in a patient with multiple sclerosis. Neurology, 53 (9). pp. 2209-2210. ISSN 0028-3878

drug classification

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

drug clearance

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

drug cost

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

drug delivery system

Blagden, N. and de Matas, M. and Gavan, P.T. and York, P. (2007) Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Advanced Drug Delivery Reviews, 59 (7). pp. 617-630. ISSN 0169-409X

drug derivative

Rose, Peter and Whiteman, Matt and Moore, Philip K. and Yi, Zhun Zhu (2005) Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents. Natural Product Reports, 22 (3). pp. 351-368. ISSN 0265-0568

drug distribution

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

drug effect

Schon, F. and Hart, P. E. and Hodgson, T. L. and Pambakian, A. L. M. and Ruprah, M. and Williamson, E.M. and Kennard, C. (1999) Suppression of pendular nystagmus by smoking cannabis in a patient with multiple sclerosis. Neurology, 53 (9). pp. 2209-2210. ISSN 0028-3878

drug efficacy

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

drug half life

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

drug impurity

Blagden, N. and Davey, R. J. and Rowe, R. and Roberts, R. (1998) Disappearing polymorphs and the role of reaction by-products: the case of sulphathiazole. International Journal of Pharmaceutics, 172 (1-2). pp. 169-177. ISSN 0378-5173

drug mechanism

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

drug metabolism

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

drug microdose

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

drug monitoring

Kirkham, Emma and Bazire, Stephen and Anderson, Timothy and Wood, John and Grassby, Paul and Desborough, James (2013) Impact of active monitoring on lithium management in Norfolk. Therapeutic Advances in Psychopharmacology, 3 (5). pp. 260-265. ISSN 2045-1253

drug penetration

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

drug research

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

drug safety

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

drug solubility

Ali, Hany S. M. and York, Peter and Blagden, Nicholas (2009) Preparation of hydrocortisone nanosuspension through a bottom-up nanoprecipitation technique using microfluidic reactors. International Journal of Pharmaceutics, 375 (1-2). pp. 107-113. ISSN 0378-5173

Blagden, N. and de Matas, M. and Gavan, P.T. and York, P. (2007) Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Advanced Drug Delivery Reviews, 59 (7). pp. 617-630. ISSN 0169-409X

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

drug stability

Davey, R. J. and Blagden, N. and Potts, G. D. and Docherty, R. (1997) Polymorphism in molecular crystals: stabilization of a metastable form by conformational mimicry. Journal of the American Chemical Society, 119 (7). pp. 1767-1772. ISSN 0002-7863

Dematos, Luciana L. and Williams, Adrian C. and Booth, Steven W. and Petts, Catherine R. and Taylor, David J. and Blagden, Nicholas (2007) Solvent influences on metastable polymorph lifetimes: real-time interconversions using energy dispersive X-ray diffractometry. Journal of Pharmaceutical Sciences, 96 (5). pp. 1069-1078. ISSN 0022-3549

drug structure

Davey, R. J. and Blagden, N. and Potts, G. D. and Docherty, R. (1997) Polymorphism in molecular crystals: stabilization of a metastable form by conformational mimicry. Journal of the American Chemical Society, 119 (7). pp. 1767-1772. ISSN 0002-7863

Dematos, Luciana L. and Williams, Adrian C. and Booth, Steven W. and Petts, Catherine R. and Taylor, David J. and Blagden, Nicholas (2007) Solvent influences on metastable polymorph lifetimes: real-time interconversions using energy dispersive X-ray diffractometry. Journal of Pharmaceutical Sciences, 96 (5). pp. 1069-1078. ISSN 0022-3549

eNOS

Bates, T. E. and Loesch, A. and Burnstock, G. and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochemical and biophysical research communications, 218 (1). pp. 40-44. ISSN 0006-291X

electron transport chain

Bates, T E and Almeida, A and Heales, S J and Clark, J B (1994) Postnatal development of the complexes of the electron transport chain in isolated rat brain mitochondria. Developmental neuroscience, 16 (5-6). pp. 321-7. ISSN 0378-5866

element

Blagden, Nicholas and Cross, Wendy I. and Davey, Roger J. and Broderick, Mairead and Pritchard, Robin G. and Roberts, Ronald J. and Rowe, Raymond C. (2001) Can crystal structure prediction be used as part of an integrated strategy for ensuring maximum diversity of isolated crystal forms? The case of 2-amino-4-nitrophenol. Physical Chemistry Chemical Physics, 3 (17). pp. 3819-3825. ISSN 1463-9076

enalapril

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

endocannabinoid

Pardon, Marie-Christine and Sarmad, Sarir and Rattray, Ivan and Bates, Timothy E. and Scullion, Gillian A. and Marsden, Charles A. and Barrett, David A. and Lowe, James and Kendall, David A. (2009) Repeated novel cage exposure-induced improvement of early Alzheimer's-like cognitive and amyloid changes in TASTPM mice is unrelated to changes in brain endocannabinoids levels. Neurobiology of Aging, 30 (7). pp. 1099-1113. ISSN 0197-4580

energy transfer

Dematos, Luciana L. and Williams, Adrian C. and Booth, Steven W. and Petts, Catherine R. and Taylor, David J. and Blagden, Nicholas (2007) Solvent influences on metastable polymorph lifetimes: real-time interconversions using energy dispersive X-ray diffractometry. Journal of Pharmaceutical Sciences, 96 (5). pp. 1069-1078. ISSN 0022-3549

enterocin

Williams, David R. and Chanos, P. (2012) Application of anti-listerial bacteriocins: monitoring enterocin expression by multiplex relative reverse transcription-PCR. Biochemical Society Transactions, 40 (6). pp. 1544-1548. ISSN 0300-5127

enzymes

Bates, T E and Almeida, A and Heales, S J and Clark, J B (1994) Postnatal development of the complexes of the electron transport chain in isolated rat brain mitochondria. Developmental neuroscience, 16 (5-6). pp. 321-7. ISSN 0378-5866

Beuck, C and Singh, I. and Bhattacharya, A and Heckler, W and Parmar, VS and Seitz, O and Weinhold, E (2003) Polycyclic aromatic DNA-Base surrogates: high-affinity binding to an adenine-specific base-flipping DNA methyltransferase. Angewandte Chemie International Edition, 42 (33). pp. 3958-3960. ISSN 1433-7851

erythromycin

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

excitotoxicity

Rosin, Claudia and Bates, Timothy E. and Skaper, Stephen D. (2004) Excitatory amino acid induced oligodendrocyte cell death in vitro: receptor-dependent and -independent mechanisms. Journal of Neurochemistry, 90 (5). pp. 1173-1185. ISSN 0022-3042

eye movement control

Golding, C. V. P. and Danchaivijitr, C. and Hodgson, T. L. and Tabrizi, S. J. and Kennard, C. (2006) Identification of an oculomotor biomarker of preclinical Huntington disease. Neurology, 67 (3). pp. 485-487. ISSN 0028-3878

factual

Kirkham, Emma and Bazire, Stephen and Anderson, Timothy and Wood, John and Grassby, Paul and Desborough, James (2013) Impact of active monitoring on lithium management in Norfolk. Therapeutic Advances in Psychopharmacology, 3 (5). pp. 260-265. ISSN 2045-1253

fast GC-MS screening

Elie, Mathieu P. and Elie, Leonie E. and Baron, Mark G. (2013) Keeping pace with NPS releases: fast GC-MS screening of legal high products. Drug Testing and Analysis, 5 (5). pp. 281-290. ISSN 1942-7603

female

Golding, C. V. P. and Danchaivijitr, C. and Hodgson, T. L. and Tabrizi, S. J. and Kennard, C. (2006) Identification of an oculomotor biomarker of preclinical Huntington disease. Neurology, 67 (3). pp. 485-487. ISSN 0028-3878

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

fentanyl

Prosser, D. and Allman, M. and Grassby, Paul (1998) Oral transmucosal fentanyl. Anaesthesia, 53 (10). p. 1030. ISSN 0003-2409

fermentation

Williams, David R. and Chanos, P. (2012) Application of anti-listerial bacteriocins: monitoring enterocin expression by multiplex relative reverse transcription-PCR. Biochemical Society Transactions, 40 (6). pp. 1544-1548. ISSN 0300-5127

fexofenadine

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

flow rate

Ali, Hany S. M. and York, Peter and Blagden, Nicholas (2009) Preparation of hydrocortisone nanosuspension through a bottom-up nanoprecipitation technique using microfluidic reactors. International Journal of Pharmaceutics, 375 (1-2). pp. 107-113. ISSN 0378-5173

fluconazole

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

folic acid

Vllasaliu, Driton and Casettari, Luca and Bonacucina, Giulia and Cespi, Marco and Filippo Palmieri, Giovanni and Illum, Lisbeth (2013) Folic acid conjugated chitosan nanoparticles for tumor targeting of therapeutic and imaging agents. Pharmaceutical Nanotechnology, 1 (3). pp. 184-203. ISSN 2211-7385

food

Williams, David R. and Chanos, P. (2012) Application of anti-listerial bacteriocins: monitoring enterocin expression by multiplex relative reverse transcription-PCR. Biochemical Society Transactions, 40 (6). pp. 1544-1548. ISSN 0300-5127

food and drug administration

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

forensic drug analysis

Elie, Mathieu P. and Elie, Leonie E. and Baron, Mark G. (2013) Keeping pace with NPS releases: fast GC-MS screening of legal high products. Drug Testing and Analysis, 5 (5). pp. 281-290. ISSN 1942-7603

fosdevirine

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

free radicals

Calabrese, Vittorio and Bates, Timothy E. and Mancuso, Cesare and Cornelius, Carolin and Ventimiglia, Bernardo and Cambria, Maria Teresa and Di Renzo, Laura and De Lorenzo, Antonino and Dinkova-Kostova, Albena T. (2008) Curcumin and the cellular stress response in free radical-related diseases. Molecular Nutrition & Food Research, 52 (9). pp. 1062-1073. ISSN 1613-4125

garlic

Rose, Peter and Whiteman, Matt and Moore, Philip K. and Yi, Zhun Zhu (2005) Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents. Natural Product Reports, 22 (3). pp. 351-368. ISSN 0265-0568

gene expression

Williams, David R. and Chanos, P. (2012) Application of anti-listerial bacteriocins: monitoring enterocin expression by multiplex relative reverse transcription-PCR. Biochemical Society Transactions, 40 (6). pp. 1544-1548. ISSN 0300-5127

gene transcription

Abdel-Razaq, W. and Bates, T. E. and Kendall, D. A. (2007) The effects of antidepressants on cyclic AMP-response element-driven gene transcription in a model cell system. Biochemical Pharmacology, 73 (12). pp. 1995-2003. ISSN 0006-2952

genetics

Golding, C. V. P. and Danchaivijitr, C. and Hodgson, T. L. and Tabrizi, S. J. and Kennard, C. (2006) Identification of an oculomotor biomarker of preclinical Huntington disease. Neurology, 67 (3). pp. 485-487. ISSN 0028-3878

glibenclamide

Blagden, N. and de Matas, M. and Gavan, P.T. and York, P. (2007) Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Advanced Drug Delivery Reviews, 59 (7). pp. 617-630. ISSN 0169-409X

glioma

Daley, E. and Wilkie, D. and Loesch, A. and Hargreaves, I. P. and Kendall, D. A. and Pilkington, G. J. and Bates, T. E. (2005) Chlorimipramine: a novel anticancer agent with a mitochondrial target. Biochemical and Biophysical Research Communications, 328 (2). pp. 623-632. ISSN 0006-291X

glutamate

Rosin, Claudia and Bates, Timothy E. and Skaper, Stephen D. (2004) Excitatory amino acid induced oligodendrocyte cell death in vitro: receptor-dependent and -independent mechanisms. Journal of Neurochemistry, 90 (5). pp. 1173-1185. ISSN 0022-3042

glutamate toxicity

Rosin, Claudia and Colombo, Sergio and Calver, Andrew A. and Bates, Timothy E. and Skaper, Stephen D. (2005) Dopamine D2 and D3 receptor agonists limit oligodendrocyte injury caused by glutamate oxidative stress and oxygen/glucose deprivation. Glia, 52 (4). pp. 336-343. ISSN 0894-1491

glutamic acid, article

Davey, R. J. and Blagden, N. and Potts, G. D. and Docherty, R. (1997) Polymorphism in molecular crystals: stabilization of a metastable form by conformational mimicry. Journal of the American Chemical Society, 119 (7). pp. 1767-1772. ISSN 0002-7863

glycoprotein P

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

glycosides

Beuck, C and Singh, I. and Bhattacharya, A and Heckler, W and Parmar, VS and Seitz, O and Weinhold, E (2003) Polycyclic aromatic DNA-Base surrogates: high-affinity binding to an adenine-specific base-flipping DNA methyltransferase. Angewandte Chemie International Edition, 42 (33). pp. 3958-3960. ISSN 1433-7851

griseofulvin

Blagden, N. and de Matas, M. and Gavan, P.T. and York, P. (2007) Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Advanced Drug Delivery Reviews, 59 (7). pp. 617-630. ISSN 0169-409X

half life time

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

high performance liquid chromatography

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

human

Golding, C. V. P. and Danchaivijitr, C. and Hodgson, T. L. and Tabrizi, S. J. and Kennard, C. (2006) Identification of an oculomotor biomarker of preclinical Huntington disease. Neurology, 67 (3). pp. 485-487. ISSN 0028-3878

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

Rose, Peter and Whiteman, Matt and Moore, Philip K. and Yi, Zhun Zhu (2005) Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents. Natural Product Reports, 22 (3). pp. 351-368. ISSN 0265-0568

Schon, F. and Hart, P. E. and Hodgson, T. L. and Pambakian, A. L. M. and Ruprah, M. and Williamson, E.M. and Kennard, C. (1999) Suppression of pendular nystagmus by smoking cannabis in a patient with multiple sclerosis. Neurology, 53 (9). pp. 2209-2210. ISSN 0028-3878

Soon, Chin Phong and Khaghani, Seyed Ali and Youseffi, Mansour and Nayan, Nafarizal and Saim, Hashim and Britland, Stephen and Blagden, Nicholas and Denyer, Morgan Clive Thomas (2013) Interfacial study of cell adhesion to liquid crystals using widefield surface plasmon resonance microscopy. Colloids and Surfaces B: Biointerfaces, 110 . pp. 156-162. ISSN 0927-7765

human tissue

Soon, Chin Phong and Khaghani, Seyed Ali and Youseffi, Mansour and Nayan, Nafarizal and Saim, Hashim and Britland, Stephen and Blagden, Nicholas and Denyer, Morgan Clive Thomas (2013) Interfacial study of cell adhesion to liquid crystals using widefield surface plasmon resonance microscopy. Colloids and Surfaces B: Biointerfaces, 110 . pp. 156-162. ISSN 0927-7765

hydration

Dematos, Luciana L. and Williams, Adrian C. and Booth, Steven W. and Petts, Catherine R. and Taylor, David J. and Blagden, Nicholas (2007) Solvent influences on metastable polymorph lifetimes: real-time interconversions using energy dispersive X-ray diffractometry. Journal of Pharmaceutical Sciences, 96 (5). pp. 1069-1078. ISSN 0022-3549

hydrocortisone, article

Ali, Hany S. M. and York, Peter and Blagden, Nicholas (2009) Preparation of hydrocortisone nanosuspension through a bottom-up nanoprecipitation technique using microfluidic reactors. International Journal of Pharmaceutics, 375 (1-2). pp. 107-113. ISSN 0378-5173

hydrogen bond

Blagden, N. and Davey, R. J. and Rowe, R. and Roberts, R. (1998) Disappearing polymorphs and the role of reaction by-products: the case of sulphathiazole. International Journal of Pharmaceutics, 172 (1-2). pp. 169-177. ISSN 0378-5173

hydrogen peroxide

Athanasiou, Andriani and Clarke, Anna B. and Turner, Amy E. and Kumaran, Nethia M. and Vakilpour, Sara and Smith, Paul A. and Bagiokou, Dimitra and Bradshaw, Tracey D. and Westwell, Andrew D. and Fang, Lin and Lobo, Dileep N. and Constantinescu, Cris S. and Calabrese, Vittorio and Loesch, Andrzej and Alexander, Stephen P. H. and Clothier, Richard H. and Kendall, David A. and Bates, Timothy E. (2007) Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications, 364 (1). pp. 131-137. ISSN 0006-291x

hydrolysis

Blagden, N. and Davey, R. J. and Rowe, R. and Roberts, R. (1998) Disappearing polymorphs and the role of reaction by-products: the case of sulphathiazole. International Journal of Pharmaceutics, 172 (1-2). pp. 169-177. ISSN 0378-5173

imaging system

Soon, Chin Phong and Khaghani, Seyed Ali and Youseffi, Mansour and Nayan, Nafarizal and Saim, Hashim and Britland, Stephen and Blagden, Nicholas and Denyer, Morgan Clive Thomas (2013) Interfacial study of cell adhesion to liquid crystals using widefield surface plasmon resonance microscopy. Colloids and Surfaces B: Biointerfaces, 110 . pp. 156-162. ISSN 0927-7765

immobilized lipas

Plieva, F. M. and Kochetkov, K. A. and Singh, Ishwar and Parmar, V. S. and Belokon', Y. N. and Lozinsky, V. I. (2000) Immobilization of hog pancreas lipase in macroporous poly(vinyl alcohol)-cryogel carrier for the biocatalysis in water-poor media. Biotechnology Letters, 22 (7). pp. 551-554. ISSN 0141-5492

immunocytochemistry

Soon, Chin Phong and Khaghani, Seyed Ali and Youseffi, Mansour and Nayan, Nafarizal and Saim, Hashim and Britland, Stephen and Blagden, Nicholas and Denyer, Morgan Clive Thomas (2013) Interfacial study of cell adhesion to liquid crystals using widefield surface plasmon resonance microscopy. Colloids and Surfaces B: Biointerfaces, 110 . pp. 156-162. ISSN 0927-7765

immunofluorescence

Soon, Chin Phong and Khaghani, Seyed Ali and Youseffi, Mansour and Nayan, Nafarizal and Saim, Hashim and Britland, Stephen and Blagden, Nicholas and Denyer, Morgan Clive Thomas (2013) Interfacial study of cell adhesion to liquid crystals using widefield surface plasmon resonance microscopy. Colloids and Surfaces B: Biointerfaces, 110 . pp. 156-162. ISSN 0927-7765

isobutanol

Dematos, Luciana L. and Williams, Adrian C. and Booth, Steven W. and Petts, Catherine R. and Taylor, David J. and Blagden, Nicholas (2007) Solvent influences on metastable polymorph lifetimes: real-time interconversions using energy dispersive X-ray diffractometry. Journal of Pharmaceutical Sciences, 96 (5). pp. 1069-1078. ISSN 0022-3549

kainate

Rosin, Claudia and Bates, Timothy E. and Skaper, Stephen D. (2004) Excitatory amino acid induced oligodendrocyte cell death in vitro: receptor-dependent and -independent mechanisms. Journal of Neurochemistry, 90 (5). pp. 1173-1185. ISSN 0022-3042

keratinocyte

Soon, C. F. and Omar, W. I. W. and Berends, R. F. and Nayan, N. and Basri, H. and Tee, K. S. and Youseffi, M. and Blagden, Nicholas and Denyer, M. C. T. (2014) Biophysical characteristics of cells cultured on cholesteryl ester liquid crystals. Micron, 56 . pp. 73-79. ISSN 0968-4328

Soon, Chin Phong and Khaghani, Seyed Ali and Youseffi, Mansour and Nayan, Nafarizal and Saim, Hashim and Britland, Stephen and Blagden, Nicholas and Denyer, Morgan Clive Thomas (2013) Interfacial study of cell adhesion to liquid crystals using widefield surface plasmon resonance microscopy. Colloids and Surfaces B: Biointerfaces, 110 . pp. 156-162. ISSN 0927-7765

kinetics

Blagden, Nicholas (2001) Crystal engineering of polymorph appearance: the case of sulphathiazole. Powder Technology, 121 (1). pp. 46-52. ISSN 0032-5910

legal highs

Elie, Mathieu P. and Elie, Leonie E. and Baron, Mark G. (2013) Keeping pace with NPS releases: fast GC-MS screening of legal high products. Drug Testing and Analysis, 5 (5). pp. 281-290. ISSN 1942-7603

lipoxygenase inhibitor

Blagden, N. and de Matas, M. and Gavan, P.T. and York, P. (2007) Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Advanced Drug Delivery Reviews, 59 (7). pp. 617-630. ISSN 0169-409X

liquid chromatography

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

liquid crystal

Soon, Chin Phong and Khaghani, Seyed Ali and Youseffi, Mansour and Nayan, Nafarizal and Saim, Hashim and Britland, Stephen and Blagden, Nicholas and Denyer, Morgan Clive Thomas (2013) Interfacial study of cell adhesion to liquid crystals using widefield surface plasmon resonance microscopy. Colloids and Surfaces B: Biointerfaces, 110 . pp. 156-162. ISSN 0927-7765

listeriosis

Williams, David R. and Chanos, P. (2012) Application of anti-listerial bacteriocins: monitoring enterocin expression by multiplex relative reverse transcription-PCR. Biochemical Society Transactions, 40 (6). pp. 1544-1548. ISSN 0300-5127

lithium

Kirkham, Emma and Bazire, Stephen and Anderson, Timothy and Wood, John and Grassby, Paul and Desborough, James (2013) Impact of active monitoring on lithium management in Norfolk. Therapeutic Advances in Psychopharmacology, 3 (5). pp. 260-265. ISSN 2045-1253

liver clearance

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

liver failure

Bates, Timothy E. and Williams, Stephen R. and Kauppinen, Risto A. and Gadian, David G. (1989) Observation of cerebral metabolites in an animal model of acute liver failure in vivo: a 1H and 31P nuclear magnetic resonance study. Journal of neurochemistry, 53 (1). pp. 102-10. ISSN 0022-3042

losartan

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

lung cancer

Athanasiou, Andriani and Smith, Paul A. and Vakilpour, Sara and Kumaran, Nethia M. and Turner, Amy E. and Bagiokou, Dimitra and Layfield, Robert and Ray, David E. and Westwell, Andrew D. and Alexander, Stephen P. H. and Kendall, David A. and Lobo, Dileep N. and Watson, Susan A. and Lophatanon, Artitaya and Muir, Kenneth A. and Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

lyase

Rose, Peter and Whiteman, Matt and Moore, Philip K. and Yi, Zhun Zhu (2005) Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents. Natural Product Reports, 22 (3). pp. 351-368. ISSN 0265-0568

male

Golding, C. V. P. and Danchaivijitr, C. and Hodgson, T. L. and Tabrizi, S. J. and Kennard, C. (2006) Identification of an oculomotor biomarker of preclinical Huntington disease. Neurology, 67 (3). pp. 485-487. ISSN 0028-3878

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Schon, F. and Hart, P. E. and Hodgson, T. L. and Pambakian, A. L. M. and Ruprah, M. and Williamson, E.M. and Kennard, C. (1999) Suppression of pendular nystagmus by smoking cannabis in a patient with multiple sclerosis. Neurology, 53 (9). pp. 2209-2210. ISSN 0028-3878

manganese [III] tetrakis 4-benzoic acid porphyrin

Brooks, Keith J. and Hargreaves, Iain P. and Bates, Timothy E. (2008) Protection of respiratory chain enzymes from ischaemic damage in adult rat brain slices. Neurochemical research, 33 (9). pp. 1711-1716. ISSN 0364-3190

mass spectrometry

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

material coating

Soon, Chin Phong and Khaghani, Seyed Ali and Youseffi, Mansour and Nayan, Nafarizal and Saim, Hashim and Britland, Stephen and Blagden, Nicholas and Denyer, Morgan Clive Thomas (2013) Interfacial study of cell adhesion to liquid crystals using widefield surface plasmon resonance microscopy. Colloids and Surfaces B: Biointerfaces, 110 . pp. 156-162. ISSN 0927-7765

medical literature

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

metabolism

Rose, Peter and Whiteman, Matt and Moore, Philip K. and Yi, Zhun Zhu (2005) Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents. Natural Product Reports, 22 (3). pp. 351-368. ISSN 0265-0568

metformin

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

methanol

Dematos, Luciana L. and Williams, Adrian C. and Booth, Steven W. and Petts, Catherine R. and Taylor, David J. and Blagden, Nicholas (2007) Solvent influences on metastable polymorph lifetimes: real-time interconversions using energy dispersive X-ray diffractometry. Journal of Pharmaceutical Sciences, 96 (5). pp. 1069-1078. ISSN 0022-3549

methodology

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

metoprolol

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

microdosing

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

microfluidics

Ali, Hany S. M. and York, Peter and Blagden, Nicholas (2009) Preparation of hydrocortisone nanosuspension through a bottom-up nanoprecipitation technique using microfluidic reactors. International Journal of Pharmaceutics, 375 (1-2). pp. 107-113. ISSN 0378-5173

microscopy

Soon, Chin Phong and Khaghani, Seyed Ali and Youseffi, Mansour and Nayan, Nafarizal and Saim, Hashim and Britland, Stephen and Blagden, Nicholas and Denyer, Morgan Clive Thomas (2013) Interfacial study of cell adhesion to liquid crystals using widefield surface plasmon resonance microscopy. Colloids and Surfaces B: Biointerfaces, 110 . pp. 156-162. ISSN 0927-7765

midazolam

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

mitochondria

Almeida, A. and Brooks, K. J. and Sammut, I. and Keelan, J. and Davey, G. P. and Clark, J. B. and Bates, T. E. (1995) Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain. Developmental Neuroscience, 17 (4). pp. 212-218. ISSN 0378-5866

Athanasiou, Andriani and Clarke, Anna B. and Turner, Amy E. and Kumaran, Nethia M. and Vakilpour, Sara and Smith, Paul A. and Bagiokou, Dimitra and Bradshaw, Tracey D. and Westwell, Andrew D. and Fang, Lin and Lobo, Dileep N. and Constantinescu, Cris S. and Calabrese, Vittorio and Loesch, Andrzej and Alexander, Stephen P. H. and Clothier, Richard H. and Kendall, David A. and Bates, Timothy E. (2007) Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications, 364 (1). pp. 131-137. ISSN 0006-291x

Athanasiou, Andriani and Smith, Paul A. and Vakilpour, Sara and Kumaran, Nethia M. and Turner, Amy E. and Bagiokou, Dimitra and Layfield, Robert and Ray, David E. and Westwell, Andrew D. and Alexander, Stephen P. H. and Kendall, David A. and Lobo, Dileep N. and Watson, Susan A. and Lophatanon, Artitaya and Muir, Kenneth A. and Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

Bates, T E and Almeida, A and Heales, S J and Clark, J B (1994) Postnatal development of the complexes of the electron transport chain in isolated rat brain mitochondria. Developmental neuroscience, 16 (5-6). pp. 321-7. ISSN 0378-5866

Mancuso, Cesare and Bates, Timothy E. and Butterfield, D. Allan and Calafato, Stella and Cornelius, Carolin and De Lorenzo, Antonino and Dinkova Kostova, Albena T. and Calabrese, Vittorio (2007) Natural antioxidants in Alzheimer's disease. Expert Opinion on Investigational Drugs, 16 (12). pp. 1921-1931. ISSN 1354-3784

mitochondrial complexes

Athanasiou, Andriani and Clarke, Anna B. and Turner, Amy E. and Kumaran, Nethia M. and Vakilpour, Sara and Smith, Paul A. and Bagiokou, Dimitra and Bradshaw, Tracey D. and Westwell, Andrew D. and Fang, Lin and Lobo, Dileep N. and Constantinescu, Cris S. and Calabrese, Vittorio and Loesch, Andrzej and Alexander, Stephen P. H. and Clothier, Richard H. and Kendall, David A. and Bates, Timothy E. (2007) Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications, 364 (1). pp. 131-137. ISSN 0006-291x

mitochondrial membrane potential

Athanasiou, Andriani and Clarke, Anna B. and Turner, Amy E. and Kumaran, Nethia M. and Vakilpour, Sara and Smith, Paul A. and Bagiokou, Dimitra and Bradshaw, Tracey D. and Westwell, Andrew D. and Fang, Lin and Lobo, Dileep N. and Constantinescu, Cris S. and Calabrese, Vittorio and Loesch, Andrzej and Alexander, Stephen P. H. and Clothier, Richard H. and Kendall, David A. and Bates, Timothy E. (2007) Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications, 364 (1). pp. 131-137. ISSN 0006-291x

molecular interaction

Soon, Chin Phong and Khaghani, Seyed Ali and Youseffi, Mansour and Nayan, Nafarizal and Saim, Hashim and Britland, Stephen and Blagden, Nicholas and Denyer, Morgan Clive Thomas (2013) Interfacial study of cell adhesion to liquid crystals using widefield surface plasmon resonance microscopy. Colloids and Surfaces B: Biointerfaces, 110 . pp. 156-162. ISSN 0927-7765

molecular model

Blagden, Nicholas (2001) Crystal engineering of polymorph appearance: the case of sulphathiazole. Powder Technology, 121 (1). pp. 46-52. ISSN 0032-5910

molecular stability

Blagden, N. and Davey, R. J. and Rowe, R. and Roberts, R. (1998) Disappearing polymorphs and the role of reaction by-products: the case of sulphathiazole. International Journal of Pharmaceutics, 172 (1-2). pp. 169-177. ISSN 0378-5173

monitoring

Williams, David R. and Chanos, P. (2012) Application of anti-listerial bacteriocins: monitoring enterocin expression by multiplex relative reverse transcription-PCR. Biochemical Society Transactions, 40 (6). pp. 1544-1548. ISSN 0300-5127

multiple sclerosis

Rosin, Claudia and Bates, Timothy E. and Skaper, Stephen D. (2004) Excitatory amino acid induced oligodendrocyte cell death in vitro: receptor-dependent and -independent mechanisms. Journal of Neurochemistry, 90 (5). pp. 1173-1185. ISSN 0022-3042

Schon, F. and Hart, P. E. and Hodgson, T. L. and Pambakian, A. L. M. and Ruprah, M. and Williamson, E.M. and Kennard, C. (1999) Suppression of pendular nystagmus by smoking cannabis in a patient with multiple sclerosis. Neurology, 53 (9). pp. 2209-2210. ISSN 0028-3878

necrosis

Athanasiou, Andriani and Smith, Paul A. and Vakilpour, Sara and Kumaran, Nethia M. and Turner, Amy E. and Bagiokou, Dimitra and Layfield, Robert and Ray, David E. and Westwell, Andrew D. and Alexander, Stephen P. H. and Kendall, David A. and Lobo, Dileep N. and Watson, Susan A. and Lophatanon, Artitaya and Muir, Kenneth A. and Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

neurodegeneration

Calabrese, Vittorio and Cornelius, Carolin and Mancuso, Cesare and Pennisi, Giovanni and Calafato, Stella and Bellia, Francesco and Bates, Timothy E. and Giuffrida Stella, Anna Maria and Schapira, Tony and Dinkova Kostova, Albena T. and Rizzarelli, Enrico (2008) Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity. Neurochemical Research, 33 (12). pp. 2444-2471. ISSN 0364-3190

neuroprotection

Calabrese, Vittorio and Cornelius, Carolin and Mancuso, Cesare and Pennisi, Giovanni and Calafato, Stella and Bellia, Francesco and Bates, Timothy E. and Giuffrida Stella, Anna Maria and Schapira, Tony and Dinkova Kostova, Albena T. and Rizzarelli, Enrico (2008) Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity. Neurochemical Research, 33 (12). pp. 2444-2471. ISSN 0364-3190

nicardipine

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

nitromethane

Dematos, Luciana L. and Williams, Adrian C. and Booth, Steven W. and Petts, Catherine R. and Taylor, David J. and Blagden, Nicholas (2007) Solvent influences on metastable polymorph lifetimes: real-time interconversions using energy dispersive X-ray diffractometry. Journal of Pharmaceutical Sciences, 96 (5). pp. 1069-1078. ISSN 0022-3549

nonhuman

Blagden, N. and de Matas, M. and Gavan, P.T. and York, P. (2007) Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Advanced Drug Delivery Reviews, 59 (7). pp. 617-630. ISSN 0169-409X

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

Williams, David R. and Chanos, P. (2012) Application of anti-listerial bacteriocins: monitoring enterocin expression by multiplex relative reverse transcription-PCR. Biochemical Society Transactions, 40 (6). pp. 1544-1548. ISSN 0300-5127

normal human

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

novel psychoactive substances

Elie, Mathieu P. and Elie, Leonie E. and Baron, Mark G. (2013) Keeping pace with NPS releases: fast GC-MS screening of legal high products. Drug Testing and Analysis, 5 (5). pp. 281-290. ISSN 1942-7603

nucleic acids}

Beuck, C and Singh, I. and Bhattacharya, A and Heckler, W and Parmar, VS and Seitz, O and Weinhold, E (2003) Polycyclic aromatic DNA-Base surrogates: high-affinity binding to an adenine-specific base-flipping DNA methyltransferase. Angewandte Chemie International Edition, 42 (33). pp. 3958-3960. ISSN 1433-7851

nutrition

Calabrese, Vittorio and Cornelius, Carolin and Mancuso, Cesare and Pennisi, Giovanni and Calafato, Stella and Bellia, Francesco and Bates, Timothy E. and Giuffrida Stella, Anna Maria and Schapira, Tony and Dinkova Kostova, Albena T. and Rizzarelli, Enrico (2008) Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity. Neurochemical Research, 33 (12). pp. 2444-2471. ISSN 0364-3190

nystagmus

Schon, F. and Hart, P. E. and Hodgson, T. L. and Pambakian, A. L. M. and Ruprah, M. and Williamson, E.M. and Kennard, C. (1999) Suppression of pendular nystagmus by smoking cannabis in a patient with multiple sclerosis. Neurology, 53 (9). pp. 2209-2210. ISSN 0028-3878

oaemailed

Garnett, Martin and Vllasaliu, Driton and Stolnik, Snow and Falcone, Franco (2014) Drug delivery: epithelial cell models for drug transport and toxicology studies. The Biochemist, 36 (3). p. 8. ISSN 0954-982X

oligodendrocyte

Rosin, Claudia and Bates, Timothy E. and Skaper, Stephen D. (2004) Excitatory amino acid induced oligodendrocyte cell death in vitro: receptor-dependent and -independent mechanisms. Journal of Neurochemistry, 90 (5). pp. 1173-1185. ISSN 0022-3042

Rosin, Claudia and Colombo, Sergio and Calver, Andrew A. and Bates, Timothy E. and Skaper, Stephen D. (2005) Dopamine D2 and D3 receptor agonists limit oligodendrocyte injury caused by glutamate oxidative stress and oxygen/glucose deprivation. Glia, 52 (4). pp. 336-343. ISSN 0894-1491

optical density

Soon, Chin Phong and Khaghani, Seyed Ali and Youseffi, Mansour and Nayan, Nafarizal and Saim, Hashim and Britland, Stephen and Blagden, Nicholas and Denyer, Morgan Clive Thomas (2013) Interfacial study of cell adhesion to liquid crystals using widefield surface plasmon resonance microscopy. Colloids and Surfaces B: Biointerfaces, 110 . pp. 156-162. ISSN 0927-7765

optical reflection

Soon, Chin Phong and Khaghani, Seyed Ali and Youseffi, Mansour and Nayan, Nafarizal and Saim, Hashim and Britland, Stephen and Blagden, Nicholas and Denyer, Morgan Clive Thomas (2013) Interfacial study of cell adhesion to liquid crystals using widefield surface plasmon resonance microscopy. Colloids and Surfaces B: Biointerfaces, 110 . pp. 156-162. ISSN 0927-7765

oxidative stress

Bates, T. E. and Heales, S. J. and Davies, S. E. and Boakye, P. and Clark, J. B. (1994) Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. Journal of neurochemistry, 63 (2). pp. 640-648. ISSN 0022-3042

Rosin, Claudia and Bates, Timothy E. and Skaper, Stephen D. (2004) Excitatory amino acid induced oligodendrocyte cell death in vitro: receptor-dependent and -independent mechanisms. Journal of Neurochemistry, 90 (5). pp. 1173-1185. ISSN 0022-3042

pH effects

Baron, M. G. and Elie, M. (2003) Temperature sensing using reversible thermochromic polymeric films. Sensors and Actuators, B: Chemical, 90 (1-3). pp. 271-275. ISSN 0925-4005

paracetamol

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

particle size

Ali, Hany S. M. and York, Peter and Blagden, Nicholas (2009) Preparation of hydrocortisone nanosuspension through a bottom-up nanoprecipitation technique using microfluidic reactors. International Journal of Pharmaceutics, 375 (1-2). pp. 107-113. ISSN 0378-5173

patient participation

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

peer review

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

peroxynitrite

Brooks, Keith J. and Hargreaves, Iain P. and Bates, Timothy E. (2008) Protection of respiratory chain enzymes from ischaemic damage in adult rat brain slices. Neurochemical research, 33 (9). pp. 1711-1716. ISSN 0364-3190

pharmacy

Singh, Ishwar and Kohli, E. and Raj, H. G. and Gyanda, K. and Jain, S. K. and Tyagi, Y. K. and Gupta, G. and Kumari, R. and Kumar, A. and Pal, G. and Prasad, A. K. and Rastogi, R. C. and Olsen, C. E. and Jain, S. C. and Parmar, V. S. (2002) Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part 9: comparison of acetoxy 4-methylcoumarins and other polyphenolic acetates reveal the specificity to acetoxy drug: protein transacetylase for pyran carbonyl group in proximity to the oxygen heteroatom. Bioorganic and Medicinal Chemistry, 10 (12). pp. 4103-4111. ISSN 0968-0896

phase transition

Blagden, N. and Davey, R. J. and Rowe, R. and Roberts, R. (1998) Disappearing polymorphs and the role of reaction by-products: the case of sulphathiazole. International Journal of Pharmaceutics, 172 (1-2). pp. 169-177. ISSN 0378-5173

phenazone

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

phenobarbital

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

phospholipid

Murphy, Elizabeth J. and Bates, Timothy E. and Williams, Stephen R. and Watson, Tracey and Brindle, Kevin M. and Rajagopalan, Bheeshma and Radda, George K. (1992) Endoplasmic reticulum: the major contributor to the PDE peak in hepatic 31P-NMR spectra at low magnetic field strengths. Biochimica et biophysica acta: biomembranes, 1111 (1). pp. 51-58. ISSN 0005-2736

photon correlation spectroscopy

Ali, Hany S. M. and York, Peter and Blagden, Nicholas (2009) Preparation of hydrocortisone nanosuspension through a bottom-up nanoprecipitation technique using microfluidic reactors. International Journal of Pharmaceutics, 375 (1-2). pp. 107-113. ISSN 0378-5173

physical chemistry

Blagden, N. and de Matas, M. and Gavan, P.T. and York, P. (2007) Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Advanced Drug Delivery Reviews, 59 (7). pp. 617-630. ISSN 0169-409X

piracetam

Dematos, Luciana L. and Williams, Adrian C. and Booth, Steven W. and Petts, Catherine R. and Taylor, David J. and Blagden, Nicholas (2007) Solvent influences on metastable polymorph lifetimes: real-time interconversions using energy dispersive X-ray diffractometry. Journal of Pharmaceutical Sciences, 96 (5). pp. 1069-1078. ISSN 0022-3549

plasma concentration-time curve

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

poly(vinyl alcohol)-cryogel carrier}

Plieva, F. M. and Kochetkov, K. A. and Singh, Ishwar and Parmar, V. S. and Belokon', Y. N. and Lozinsky, V. I. (2000) Immobilization of hog pancreas lipase in macroporous poly(vinyl alcohol)-cryogel carrier for the biocatalysis in water-poor media. Biotechnology Letters, 22 (7). pp. 551-554. ISSN 0141-5492

positron emission tomography

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

precipitation

Ali, Hany S. M. and York, Peter and Blagden, Nicholas (2009) Preparation of hydrocortisone nanosuspension through a bottom-up nanoprecipitation technique using microfluidic reactors. International Journal of Pharmaceutics, 375 (1-2). pp. 107-113. ISSN 0378-5173

presenilin-1

Pardon, Marie-Christine and Sarmad, Sarir and Rattray, Ivan and Bates, Timothy E. and Scullion, Gillian A. and Marsden, Charles A. and Barrett, David A. and Lowe, James and Kendall, David A. (2009) Repeated novel cage exposure-induced improvement of early Alzheimer's-like cognitive and amyloid changes in TASTPM mice is unrelated to changes in brain endocannabinoids levels. Neurobiology of Aging, 30 (7). pp. 1099-1113. ISSN 0197-4580

priority journal

Ali, Hany S. M. and York, Peter and Blagden, Nicholas (2009) Preparation of hydrocortisone nanosuspension through a bottom-up nanoprecipitation technique using microfluidic reactors. International Journal of Pharmaceutics, 375 (1-2). pp. 107-113. ISSN 0378-5173

Blagden, N. and Davey, R. J. and Rowe, R. and Roberts, R. (1998) Disappearing polymorphs and the role of reaction by-products: the case of sulphathiazole. International Journal of Pharmaceutics, 172 (1-2). pp. 169-177. ISSN 0378-5173

Blagden, N. and de Matas, M. and Gavan, P.T. and York, P. (2007) Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Advanced Drug Delivery Reviews, 59 (7). pp. 617-630. ISSN 0169-409X

Golding, C. V. P. and Danchaivijitr, C. and Hodgson, T. L. and Tabrizi, S. J. and Kennard, C. (2006) Identification of an oculomotor biomarker of preclinical Huntington disease. Neurology, 67 (3). pp. 485-487. ISSN 0028-3878

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Schon, F. and Hart, P. E. and Hodgson, T. L. and Pambakian, A. L. M. and Ruprah, M. and Williamson, E.M. and Kennard, C. (1999) Suppression of pendular nystagmus by smoking cannabis in a patient with multiple sclerosis. Neurology, 53 (9). pp. 2209-2210. ISSN 0028-3878

Soon, Chin Phong and Khaghani, Seyed Ali and Youseffi, Mansour and Nayan, Nafarizal and Saim, Hashim and Britland, Stephen and Blagden, Nicholas and Denyer, Morgan Clive Thomas (2013) Interfacial study of cell adhesion to liquid crystals using widefield surface plasmon resonance microscopy. Colloids and Surfaces B: Biointerfaces, 110 . pp. 156-162. ISSN 0927-7765

Williams, David R. and Chanos, P. (2012) Application of anti-listerial bacteriocins: monitoring enterocin expression by multiplex relative reverse transcription-PCR. Biochemical Society Transactions, 40 (6). pp. 1544-1548. ISSN 0300-5127

priority journal, Administration, Oral

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

propafenone

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

prostaglandin synthase inhibitor

Blagden, N. and de Matas, M. and Gavan, P.T. and York, P. (2007) Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Advanced Drug Delivery Reviews, 59 (7). pp. 617-630. ISSN 0169-409X

protein polymorphism

Davey, R. J. and Blagden, N. and Potts, G. D. and Docherty, R. (1997) Polymorphism in molecular crystals: stabilization of a metastable form by conformational mimicry. Journal of the American Chemical Society, 119 (7). pp. 1767-1772. ISSN 0002-7863

psychiatry

Kirkham, Emma and Bazire, Stephen and Anderson, Timothy and Wood, John and Grassby, Paul and Desborough, James (2013) Impact of active monitoring on lithium management in Norfolk. Therapeutic Advances in Psychopharmacology, 3 (5). pp. 260-265. ISSN 2045-1253

quinidine

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

raltegravir

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

reactor

Ali, Hany S. M. and York, Peter and Blagden, Nicholas (2009) Preparation of hydrocortisone nanosuspension through a bottom-up nanoprecipitation technique using microfluidic reactors. International Journal of Pharmaceutics, 375 (1-2). pp. 107-113. ISSN 0378-5173

redox homeostasis

Calabrese, Vittorio and Cornelius, Carolin and Mancuso, Cesare and Pennisi, Giovanni and Calafato, Stella and Bellia, Francesco and Bates, Timothy E. and Giuffrida Stella, Anna Maria and Schapira, Tony and Dinkova Kostova, Albena T. and Rizzarelli, Enrico (2008) Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity. Neurochemical Research, 33 (12). pp. 2444-2471. ISSN 0364-3190

redox state

Calabrese, Vittorio and Cornelius, Carolin and Mancuso, Cesare and Pennisi, Giovanni and Calafato, Stella and Bellia, Francesco and Bates, Timothy E. and Giuffrida Stella, Anna Maria and Schapira, Tony and Dinkova Kostova, Albena T. and Rizzarelli, Enrico (2008) Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity. Neurochemical Research, 33 (12). pp. 2444-2471. ISSN 0364-3190

redox-dependent

Mancuso, Cesare and Bates, Timothy E. and Butterfield, D. Allan and Calafato, Stella and Cornelius, Carolin and De Lorenzo, Antonino and Dinkova Kostova, Albena T. and Calabrese, Vittorio (2007) Natural antioxidants in Alzheimer's disease. Expert Opinion on Investigational Drugs, 16 (12). pp. 1921-1931. ISSN 1354-3784

refraction index

Soon, Chin Phong and Khaghani, Seyed Ali and Youseffi, Mansour and Nayan, Nafarizal and Saim, Hashim and Britland, Stephen and Blagden, Nicholas and Denyer, Morgan Clive Thomas (2013) Interfacial study of cell adhesion to liquid crystals using widefield surface plasmon resonance microscopy. Colloids and Surfaces B: Biointerfaces, 110 . pp. 156-162. ISSN 0927-7765

resiniferatoxin

Athanasiou, Andriani and Smith, Paul A. and Vakilpour, Sara and Kumaran, Nethia M. and Turner, Amy E. and Bagiokou, Dimitra and Layfield, Robert and Ray, David E. and Westwell, Andrew D. and Alexander, Stephen P. H. and Kendall, David A. and Lobo, Dileep N. and Watson, Susan A. and Lophatanon, Artitaya and Muir, Kenneth A. and Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

respiratory chain complexes

Brooks, Keith J. and Hargreaves, Iain P. and Bates, Timothy E. (2008) Protection of respiratory chain enzymes from ischaemic damage in adult rat brain slices. Neurochemical research, 33 (9). pp. 1711-1716. ISSN 0364-3190

resveratrol

Mancuso, Cesare and Bates, Timothy E. and Butterfield, D. Allan and Calafato, Stella and Cornelius, Carolin and De Lorenzo, Antonino and Dinkova Kostova, Albena T. and Calabrese, Vittorio (2007) Natural antioxidants in Alzheimer's disease. Expert Opinion on Investigational Drugs, 16 (12). pp. 1921-1931. ISSN 1354-3784

reverse transcription polymerase chain reaction

Williams, David R. and Chanos, P. (2012) Application of anti-listerial bacteriocins: monitoring enterocin expression by multiplex relative reverse transcription-PCR. Biochemical Society Transactions, 40 (6). pp. 1544-1548. ISSN 0300-5127

review

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

review, Allium

Rose, Peter and Whiteman, Matt and Moore, Philip K. and Yi, Zhun Zhu (2005) Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents. Natural Product Reports, 22 (3). pp. 351-368. ISSN 0265-0568

review, Biological Availability

Blagden, N. and de Matas, M. and Gavan, P.T. and York, P. (2007) Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Advanced Drug Delivery Reviews, 59 (7). pp. 617-630. ISSN 0169-409X

saccadic eye movement

Golding, C. V. P. and Danchaivijitr, C. and Hodgson, T. L. and Tabrizi, S. J. and Kennard, C. (2006) Identification of an oculomotor biomarker of preclinical Huntington disease. Neurology, 67 (3). pp. 485-487. ISSN 0028-3878

scanning electron microscopy

Ali, Hany S. M. and York, Peter and Blagden, Nicholas (2009) Preparation of hydrocortisone nanosuspension through a bottom-up nanoprecipitation technique using microfluidic reactors. International Journal of Pharmaceutics, 375 (1-2). pp. 107-113. ISSN 0378-5173

schizophrenia

Rosin, Claudia and Colombo, Sergio and Calver, Andrew A. and Bates, Timothy E. and Skaper, Stephen D. (2005) Dopamine D2 and D3 receptor agonists limit oligodendrocyte injury caused by glutamate oxidative stress and oxygen/glucose deprivation. Glia, 52 (4). pp. 336-343. ISSN 0894-1491

simulation

Blagden, Nicholas and Cross, Wendy I. and Davey, Roger J. and Broderick, Mairead and Pritchard, Robin G. and Roberts, Ronald J. and Rowe, Raymond C. (2001) Can crystal structure prediction be used as part of an integrated strategy for ensuring maximum diversity of isolated crystal forms? The case of 2-amino-4-nitrophenol. Physical Chemistry Chemical Physics, 3 (17). pp. 3819-3825. ISSN 1463-9076

smoking

Schon, F. and Hart, P. E. and Hodgson, T. L. and Pambakian, A. L. M. and Ruprah, M. and Williamson, E.M. and Kennard, C. (1999) Suppression of pendular nystagmus by smoking cannabis in a patient with multiple sclerosis. Neurology, 53 (9). pp. 2209-2210. ISSN 0028-3878

solid phase extraction

Blagden, Nicholas and Cross, Wendy I. and Davey, Roger J. and Broderick, Mairead and Pritchard, Robin G. and Roberts, Ronald J. and Rowe, Raymond C. (2001) Can crystal structure prediction be used as part of an integrated strategy for ensuring maximum diversity of isolated crystal forms? The case of 2-amino-4-nitrophenol. Physical Chemistry Chemical Physics, 3 (17). pp. 3819-3825. ISSN 1463-9076

solid state

Blagden, Nicholas and Cross, Wendy I. and Davey, Roger J. and Broderick, Mairead and Pritchard, Robin G. and Roberts, Ronald J. and Rowe, Raymond C. (2001) Can crystal structure prediction be used as part of an integrated strategy for ensuring maximum diversity of isolated crystal forms? The case of 2-amino-4-nitrophenol. Physical Chemistry Chemical Physics, 3 (17). pp. 3819-3825. ISSN 1463-9076

solvation

Blagden, Nicholas and Cross, Wendy I. and Davey, Roger J. and Broderick, Mairead and Pritchard, Robin G. and Roberts, Ronald J. and Rowe, Raymond C. (2001) Can crystal structure prediction be used as part of an integrated strategy for ensuring maximum diversity of isolated crystal forms? The case of 2-amino-4-nitrophenol. Physical Chemistry Chemical Physics, 3 (17). pp. 3819-3825. ISSN 1463-9076

solvent

Blagden, Nicholas and Cross, Wendy I. and Davey, Roger J. and Broderick, Mairead and Pritchard, Robin G. and Roberts, Ronald J. and Rowe, Raymond C. (2001) Can crystal structure prediction be used as part of an integrated strategy for ensuring maximum diversity of isolated crystal forms? The case of 2-amino-4-nitrophenol. Physical Chemistry Chemical Physics, 3 (17). pp. 3819-3825. ISSN 1463-9076

solvent effect

Dematos, Luciana L. and Williams, Adrian C. and Booth, Steven W. and Petts, Catherine R. and Taylor, David J. and Blagden, Nicholas (2007) Solvent influences on metastable polymorph lifetimes: real-time interconversions using energy dispersive X-ray diffractometry. Journal of Pharmaceutical Sciences, 96 (5). pp. 1069-1078. ISSN 0022-3549

solvent, chemical engineering

Blagden, Nicholas (2001) Crystal engineering of polymorph appearance: the case of sulphathiazole. Powder Technology, 121 (1). pp. 46-52. ISSN 0032-5910

spectral editing

Gadian, D. G. and Bates, T. E. and Williams, S. R. and Bell, J. D. and Austin, S. J. and Connelly, A. (1991) Approaches to editing, assignment and interpretation of proton spectra. NMR in biomedicine, 4 (2). pp. 85-89. ISSN 0952-3480

sub-classification

Broadley, K. J. and Chess-Williams, R. G. and Grassby, P. F. (1986) A physiological basis for subclassifying beta-adrenoceptors examined by chemical sympathectomy of guinea-pigs. Journal of Physiology, 373 (1). pp. 367-378. ISSN 0022-3751

sulfathiazole, aqueous solution

Blagden, N. and Davey, R. J. and Rowe, R. and Roberts, R. (1998) Disappearing polymorphs and the role of reaction by-products: the case of sulphathiazole. International Journal of Pharmaceutics, 172 (1-2). pp. 169-177. ISSN 0378-5173

sulfathiazole, crystal

Blagden, Nicholas (2001) Crystal engineering of polymorph appearance: the case of sulphathiazole. Powder Technology, 121 (1). pp. 46-52. ISSN 0032-5910

sulfoxide, catalysis

Rose, Peter and Whiteman, Matt and Moore, Philip K. and Yi, Zhun Zhu (2005) Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents. Natural Product Reports, 22 (3). pp. 351-368. ISSN 0265-0568

sumatriptan

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

superoxide dismutase

Brooks, Keith J. and Hargreaves, Iain P. and Bates, Timothy E. (2008) Protection of respiratory chain enzymes from ischaemic damage in adult rat brain slices. Neurochemical research, 33 (9). pp. 1711-1716. ISSN 0364-3190

surface property

Soon, Chin Phong and Khaghani, Seyed Ali and Youseffi, Mansour and Nayan, Nafarizal and Saim, Hashim and Britland, Stephen and Blagden, Nicholas and Denyer, Morgan Clive Thomas (2013) Interfacial study of cell adhesion to liquid crystals using widefield surface plasmon resonance microscopy. Colloids and Surfaces B: Biointerfaces, 110 . pp. 156-162. ISSN 0927-7765

suspension

Ali, Hany S. M. and York, Peter and Blagden, Nicholas (2009) Preparation of hydrocortisone nanosuspension through a bottom-up nanoprecipitation technique using microfluidic reactors. International Journal of Pharmaceutics, 375 (1-2). pp. 107-113. ISSN 0378-5173

tandem mass spectrometry

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

tegmentum, Eye Movements

Schon, F. and Hart, P. E. and Hodgson, T. L. and Pambakian, A. L. M. and Ruprah, M. and Williamson, E.M. and Kennard, C. (1999) Suppression of pendular nystagmus by smoking cannabis in a patient with multiple sclerosis. Neurology, 53 (9). pp. 2209-2210. ISSN 0028-3878

telmisartan

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

temperature sensitivity

Dematos, Luciana L. and Williams, Adrian C. and Booth, Steven W. and Petts, Catherine R. and Taylor, David J. and Blagden, Nicholas (2007) Solvent influences on metastable polymorph lifetimes: real-time interconversions using energy dispersive X-ray diffractometry. Journal of Pharmaceutical Sciences, 96 (5). pp. 1069-1078. ISSN 0022-3549

tenofovir

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

thermodynamics

Dematos, Luciana L. and Williams, Adrian C. and Booth, Steven W. and Petts, Catherine R. and Taylor, David J. and Blagden, Nicholas (2007) Solvent influences on metastable polymorph lifetimes: real-time interconversions using energy dispersive X-ray diffractometry. Journal of Pharmaceutical Sciences, 96 (5). pp. 1069-1078. ISSN 0022-3549

tolbutamide

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

toxicology

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

transmission electron microscopy

Ali, Hany S. M. and York, Peter and Blagden, Nicholas (2009) Preparation of hydrocortisone nanosuspension through a bottom-up nanoprecipitation technique using microfluidic reactors. International Journal of Pharmaceutics, 375 (1-2). pp. 107-113. ISSN 0378-5173

transmucosal

Prosser, D. and Allman, M. and Grassby, Paul (1998) Oral transmucosal fentanyl. Anaesthesia, 53 (10). p. 1030. ISSN 0003-2409

tricyclic

Daley, E. and Wilkie, D. and Loesch, A. and Hargreaves, I. P. and Kendall, D. A. and Pilkington, G. J. and Bates, T. E. (2005) Chlorimipramine: a novel anticancer agent with a mitochondrial target. Biochemical and Biophysical Research Communications, 328 (2). pp. 623-632. ISSN 0006-291X

tubercidin

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

unclassified drug

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

unclassified drug, area under the curve

Blagden, N. and de Matas, M. and Gavan, P.T. and York, P. (2007) Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Advanced Drug Delivery Reviews, 59 (7). pp. 617-630. ISSN 0169-409X

unclassified drug, article

Blagden, Nicholas and Cross, Wendy I. and Davey, Roger J. and Broderick, Mairead and Pritchard, Robin G. and Roberts, Ronald J. and Rowe, Raymond C. (2001) Can crystal structure prediction be used as part of an integrated strategy for ensuring maximum diversity of isolated crystal forms? The case of 2-amino-4-nitrophenol. Physical Chemistry Chemical Physics, 3 (17). pp. 3819-3825. ISSN 1463-9076

unclassified drug, bacterial strain

Williams, David R. and Chanos, P. (2012) Application of anti-listerial bacteriocins: monitoring enterocin expression by multiplex relative reverse transcription-PCR. Biochemical Society Transactions, 40 (6). pp. 1544-1548. ISSN 0300-5127

unindexed drug

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

verapamil

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

virulence, Anti-Bacterial Agents

Williams, David R. and Chanos, P. (2012) Application of anti-listerial bacteriocins: monitoring enterocin expression by multiplex relative reverse transcription-PCR. Biochemical Society Transactions, 40 (6). pp. 1544-1548. ISSN 0300-5127

vitagenes

Mancuso, Cesare and Bates, Timothy E. and Butterfield, D. Allan and Calafato, Stella and Cornelius, Carolin and De Lorenzo, Antonino and Dinkova Kostova, Albena T. and Calabrese, Vittorio (2007) Natural antioxidants in Alzheimer's disease. Expert Opinion on Investigational Drugs, 16 (12). pp. 1921-1931. ISSN 1354-3784

voluntary movement, Adult

Golding, C. V. P. and Danchaivijitr, C. and Hodgson, T. L. and Tabrizi, S. J. and Kennard, C. (2006) Identification of an oculomotor biomarker of preclinical Huntington disease. Neurology, 67 (3). pp. 485-487. ISSN 0028-3878

volunteer

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

warfarin

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

water, article

Dematos, Luciana L. and Williams, Adrian C. and Booth, Steven W. and Petts, Catherine R. and Taylor, David J. and Blagden, Nicholas (2007) Solvent influences on metastable polymorph lifetimes: real-time interconversions using energy dispersive X-ray diffractometry. Journal of Pharmaceutical Sciences, 96 (5). pp. 1069-1078. ISSN 0022-3549

widefield surface plasmon resonance microscopy

Soon, Chin Phong and Khaghani, Seyed Ali and Youseffi, Mansour and Nayan, Nafarizal and Saim, Hashim and Britland, Stephen and Blagden, Nicholas and Denyer, Morgan Clive Thomas (2013) Interfacial study of cell adhesion to liquid crystals using widefield surface plasmon resonance microscopy. Colloids and Surfaces B: Biointerfaces, 110 . pp. 156-162. ISSN 0927-7765

zeta potential, Anti-Inflammatory Agents

Ali, Hany S. M. and York, Peter and Blagden, Nicholas (2009) Preparation of hydrocortisone nanosuspension through a bottom-up nanoprecipitation technique using microfluidic reactors. International Journal of Pharmaceutics, 375 (1-2). pp. 107-113. ISSN 0378-5173

zidovudine, area under the curve

Lappin, Graham and Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255

zk 253, adult

Lappin, Graham and Kuhnz, Wilhelm and Jochemsen, Roeline and Kneer, Johannes and Chaudhary, Ajai and Oosterhuis, Berend and Drijfhout, Willem Jan and Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

zk 253, area under the curve

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

This list was generated on Wed Aug 27 11:30:21 2014 BST.