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(E) - capsaicin 1-methyl-4-phenylpyridinium 13C 1H 31P 4 aminobutyric acid AEA AME AMPA ATP Adolescent Adult Age Age of Onset Aged Aged, 80 and over Ageing Aging Alleles Allopurinol Alzheimer's Animal Animals Animals, Newborn Antibodies Antibodies, Monoclonal Antibody Formation Antibody Specificity Antigen-Antibody Reactions Antigens Antigens, Surface Antioxidant Antioxidants Arabs Autoantibodies Autoantigens Autoimmune Diseases Autoimmunity Autoradiography Azo Compounds B lymphocyte BAY 57-1293 BSO BV2 Base Sequence Belgium Binding Sites, Antibody Binding, Competitive Biological Markers Blood Glucose Body Mass Index Brain Brain Chemistry Brain Slices Brain Tumour C peptide C-Peptide Ca2+ Calcium Cancer Carbohydrates Cathepsin Cell Fractionation Cell Line Cell Membrane Cell Proliferation Cell Transplantation Cells, Cultured Cellular stress response Centrifugation, Density Gradient Child Child, Preschool Chronic Disease Clinical application Cloning, Molecular Cohort Studies Comparative Study Complex I Complexes Cross Reactions Cross-Sectional Studies Cyclosporine Cytoplasm D2 receptor D3 receptor DNA Primers Decision Trees Delta-9-tetrahydrocannabinol Development Diabetes Diabetes Mellitus Diabetes Mellitus, Experimental Diabetes Mellitus, Insulin-Dependent Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Diabetes, Gestational Dietary antioxidants Disease Progression Disease Susceptibility Diseases in Twins Dithizone EM ET EVI1 Electron Microscopy Electron Transport Chain Electrophoresis, Gel, Two-Dimensional Electrophoresis, Polyacrylamide Gel Endothelial function Epitopes Exercise Family Fathers Fatty acide ethyl esters Female Fluorescent Antibody Technique Fluorescent Antibody Technique, Indirect Follow-Up Studies Forecasting GATA1 GSH Gene Expression Regulation, Bacterial Genes, MHC Class II Genetic Predisposition to Disease Gerbil Glucagon Glucose Glucose Tolerance Test Glutamate Decarboxylase Glutamate receptors Glutathione H202 H460 HLA Antigens HLA DQ antigen HLA DR1 antigen HLA DR13 antigen HLA DR3 antigen HLA DR4 antigen HLA DR4 antigen, adult HLA antigen HLA antigen class 1 HLA antigen class 2 HLA antigen class 2, adolescent HLA system HLA-D Antigens HLA-DQ Antigens HLA-DR Antigens HLA-DR3 Antigen HLA-DR4 Antigen HSP 70 HSP's HU 210 Haplotypes Heart Heat Heat Shock Heat-Shock Proteins Hemoglobin A, Glycosylated Hepatocytes Histocompatibility Antigens Class I Histocompatibility Antigens Class II Homeodomain Proteins Humans Hydrogen peroxide Hydrolysis Hypoglycemic Agents Hypothermia IA 2 antigen IA 2beta antigen ICA512 autoantibody IPTP Ia 2 antigen Ia antibody Ia antigen Immumnoelectron microscopy Immunocytochemistry Immunodominant Epitopes Immunoglobulin G Immunohistochemistry Immunology Immunoprecipitation Immunosorbent Techniques Immunosuppressive Agents Infant Infant, Newborn Insulin Insulin Antibodies Interferon gamma Iodine Radioisotopes Iontophoresis Ischaemia Ischemia Islets of Langerhans Islets of Langerhans Transplantation Isoenzymes J774 Kidney L-buthionine sulfoximine LASCA LDF LPS Laser Doppler flowmetry Laser Doppler fluximetry Lectins Life Tables Lipopolysaccharide Liver MCAO MPN MPP+ MPT Pore MPTP MRS Male Mass Screening Membrane Glycoproteins Membrane Proteins Mice Mice, Inbred BALB C Mice, Inbred NOD Mice, SCID Microbial Collagenase Microvascular perfusion Middle Age Middle Aged Mitochondria Mitochondrial complexes Molecular Sequence Data Molecular Weight Mothers Mutation N omega-nitro-L-arginine N-Acetylaspartate N-acetylaspartate N11 NAA NMR NMR Spectroscopy NMR spectroscopy NO NOS Neoplasm Proteins Nerve Tissue Proteins Nitric Oxide Synthase Nitric oxide Nitric oxide synthase Nuclear Family Organ Preservation Solutions Organ Specificity Osmolar Concentration Ovarian Neoplasms Oxidative Phosphorylation Oxidative Stress Oxidative phsphorylation Oxidative stress PBN Pancreas Pancreas Transplantation Pancreatic Neoplasms Parkinson's disease Peptide Fragments Peptide Mapping Peptides Phosphodiester Placebos Plasmids Polyendocrinopathies, Autoimmune Polymerase Chain Reaction Polymorphism, Genetic Precipitin Tests Prediabetic State Predictive Value of Tests Pregnancy Pregnancy in Diabetics Prevalence Primary care Prospective Studies Prostate cancer Protein Footprinting Protein-Tyrosine-Phosphatase Proteins RCT RUNX1 RUNx1 Rabbits Radioimmunoprecipitation Assay Radioligand Assay Raffinose Rats Rats, Inbred Strains Rats, Wistar Recombinant Fusion Proteins Recombinant Proteins Recombinant Proteins, Escherichia coli Reference Values Registries Regression Analysis Reperfusion Reperfusion injury Reproducibility Reproducibility of Results Respiratory chain Reverse Transcriptase Polymerase Chain Reaction Risk Risk Assessment Risk Factors S-nitrosothiols SB366791 SCID mouse SCID mouse, Adenosine Saudi Arabia Saudi Arabia, Adult Sensitivity and Specificity Sex Characteristics Skeletal Muscle Skin blood flow Somatostatin Stiff-Person Syndrome Sulfur Radioisotopes Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Sweden Synaptic Synaptosomal Synaptosomes T lymphocyte, Adolescent T-Lymphocytes TASTPM THC TRPV1 Time Factors Tissue Distribution Tissue Survival Tissue and Organ Harvesting Trans-Activators Transfection Transplantation Trypsin Trypsin, Human herpesvirus 4 Twins, Dizygotic Twins, Monozygotic Type 1 diabetes United Kingdom, Adult Vanilloid Vanilloids acetyl carnitine acetyl-L-carnitine activin A adult age age distribution aged aging aglycemia algorithm allele amino acid amino terminal sequence amyloid amyloid precursor protein anandamide animal cell animal experiment animal model animal tissue antibody antibody blood level antibody detection antibody response antibody specificity antibody titer antibody, autoimmunity anticancer antidepressants antidiabetic agent antigen antigen antibody complex antigen antibody reaction antigen binding antigen detection antigen expression antigen presentation antigen recognition antigen specificity antisense cDNA apoptosis arm-cranking exercise article autoantibody autoantigen autoantigen, adolescent autoantigen, article autoimmune disease autoimmune polyendocrinopathy autoimmunity autoradiography b lymphocyte betacellulin binding affinity biological marker biotin blood blood flow blood level blood sampling bmjaccents bmjanomaly bmjdoi bmjgoldcheck brain brain enzyme brain slices c peptide calcium cancer candidiasis cannabinoid capsazepine carboxy terminal sequence cardiac cell culture cell damage cell differentiation cell fractionation cell growth cell invasion cell isolation cell line cell proliferation cell protein cell survival cell viability cellular distribution cellular stress cerebral ischaemia cerebral ischemia cerebroprotection child childhood disease chimera chlorimipramine clinical article clinical trial clomipramine cohort analysis comparative study complementary dna complexexs conference paper controlled clinical trial controlled study cross reaction curcumin cutaneous microcirculation cyclosporin cytochemistry cytochrome oxidase cytokeratin cytoplasm densitometry density gradient development diabetes Education competencies diabetes mellitus diagnosis diagnostic value disease association disease course disease duration disease marker disease predisposition dithizone, animal cell dizygotic twins dopamine dopamine receptor dysfunction eNOS ectodermal dysplasia electron transport chain electrophoresis endocannabinoid endocrine disease enzyme activity enzyme antibody enzymes epitope epitope mapping epstein barr virus escherichia coli ethanol ethnic group etiology excitotoxicity exocrine cell familial disease family family study fatty acids female fibroblast fluorescent antibody technique follow up free radicals function gene gene mapping genetic marker genetic polymorphism genetic predisposition genetic susceptibility genetic transfection genetics genotype glioma glucagon glucose glucose blood level glucose tolerance test glutamate glutamate decarboxylase glutamate decarboxylase 65 glutamate decarboxylase 65 antibody glutamate decarboxylase, adolescent glutamate toxicity glutathione glutatione glycosylated hemoglobin glycosylation graves disease hamster haplotype heat heat Stress heat shock protein, animal cell helicase herpes simplex high risk patient high risk population histology human human cell human cell culture human tissue humoral immunity hybrid protein hydrazine hydrogen peroxide hyperglycemia hypothermia hypoxia ia 2 antibody immune response immunoassay immunoblotting immunocytochemistry immunofluorescence immunofluorescence test immunoglobulin g, article immunohistochemistry immunology immunoprecipitation immunostimulation immunosuppressive agent immunosuppressive treatment impaired glucose tolerance incidence infant inflammation insulin insulin antibody insulin antibody, adult insulin dependent diabetes mellitus insulin release insulin synthesis insulin treatment insulin, adult insulinoma iodine 125 ischemia isoenzyme, adolescent isotope labeling jak2 kainate kidney laser Doppler flowmetry life table liver longevity lung cancer major clinical study male malic enzyme manganese [III] tetrakis 4-benzoic acid porphyrin marker measurement methionine methionine synthase methodology microglia middle aged mitochondria mitochondrial complexes mitochondrial membrane potential mitochondris molecular cloning molecular weight monoclonal antibody monoclonal antibody 76F monolayer culture monozygotic twins morphometrics mouse mouse infection model multicenter study multiple endocrine adenomatosis multiple sclerosis mutation necrosis neonatal nestin neurodegeneration neuroprotection newborn nicotinamide nitric oxide nitrotyrosine non insulin dependent diabetes mellitus nonhuman nuclear family nutrition oligodendrocyte onset age oral antidiabetic agent oral glucose tolerance test oxidative stress pancreas pancreas islet pancreas islet antibody pancreas islet beta cell pancreas islet cell pancreas islet cell antibody pancreas islet cell antibody, adolescent pancreas islet cell antibody, adult pancreas islet cell antibody, animal pancreas islet cell function pancreas islet cell protein pancreas islet cell, Animal pancreas islet transplantation pancreatitis parent pathogenesis perfusion perinatal period permeability transition pore peroxynitrite phenotype phosphatase, adolescent phospholipid placebo, article polyendocrinopathy prediction prediction and forecasting pregnancy diabetes mellitus preschool child preschool child, Adolescent presenilin-1 prevalence primase priority journal priority journal, Adolescent priority journal, Adult priority journal, Animal priority journal, Antibody Specificity progeny, Animals prognosis prospective study prostate cancer protein analysis protein analysis, Animals protein antibody protein antibody, adolescent protein conformation protein degradation, Antigen-Antibody Reactions protein expression protein tyrosine phosphatase protein tyrosine phosphatase, adolescent protein tyrosine phosphatase, adult protein tyrosine phosphatase, article protein tyrosine phosphatase, autoimmunity protein, antigen binding purification quality control radioassay radioimmunoprecipitation randomized controlled trial rat rat strain rat, Adolescent rat, Amino Acid Sequence rat, Animal rat, Antibody Specificity reactivity recombinant protein recombinant protein, adolescent redox redox homeostasis redox state redox-dependent reference value register relative, Adolescent reliability remission reperfusion resiniferatoxin resistance respiratory chain complexes resveratrol review review, Animal review, Autoantibodies risk risk factor schizophrenia school child school child, Adolescent screening test, Adolescent screening, Adolescent serum, Adolescent sexual development, Adolescent skin skin blood flow skin temperature staining stiff man syndrome, Adolescent stiff man syndrome, Adult storage streptavidin streptozocin diabetes streptozocin diabetes, Animals streptozocin, animal experiment streptozocin, animal model sulfur sulfur 35, adolescent superoxide dismutase supravital stain, Animal sweden, Animal t lymphocyte, Adenocarcinoma t lymphocyte, Autoantibodies time, Adult tissue culture, Adolescent tissue distribution, Animal training transcription factor PDX 1 treatment failure treatment outcome, Adolescent tricyclic trypsin trypsin, affinity chromatography trypsin, amino acid sequence twin discordance, Adolescent tyrosine phosphatase ubiquinone unclassified drug, adolescent unclassified drug, adult unclassified drug, animal cell unclassified drug, antibody specificity unclassified drug, human vimentin, animal experiment virus vitagenes vitamin E
Number of items at this level: 1843.

(E) - capsaicin

Athanasiou, Andriani and Smith, Paul A. and Vakilpour, Sara and Kumaran, Nethia M. and Turner, Amy E. and Bagiokou, Dimitra and Layfield, Robert and Ray, David E. and Westwell, Andrew D. and Alexander, Stephen P. H. and Kendall, David A. and Lobo, Dileep N. and Watson, Susan A. and Lophatanon, Artitaya and Muir, Kenneth A. and Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

1-methyl-4-phenylpyridinium

Bates, T. E. and Heales, S. J. and Davies, S. E. and Boakye, P. and Clark, J. B. (1994) Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. Journal of neurochemistry, 63 (2). pp. 640-648. ISSN 0022-3042

13C

Bakken, Inger J. and Sonnewald, Ursula and Clark, John B. and Bates, Timothy E. (1997) [U-13C]glutamate metabolism in rat brain mitochondria reveals malic enzyme activity. Neuroreport, 8 (7). pp. 1567-1570. ISSN 0959-4965

1H

Bates, Timothy E. and Strangward, Maria and Keelan, Julia and Davey, Gavin P. and Munro, Peter M. G. and Clark, John B. (1996) Inhibition of N-acetylaspartate production: implications for 1H MRS studies in vivo. Neuroreport, 7 (8). pp. 1397-1400. ISSN 0959-4965

Brooks, K. J. and Clark, J. B. and Bates, T. E. (1996) Assessment of energy metabolism in the developing brain following aglycemic hypoxia by 1H and 31P NMR. Neurochemical Research, 21 (9). pp. 1089-1095. ISSN 0364-3190

31P

Brooks, K. J. and Clark, J. B. and Bates, T. E. (1996) Assessment of energy metabolism in the developing brain following aglycemic hypoxia by 1H and 31P NMR. Neurochemical Research, 21 (9). pp. 1089-1095. ISSN 0364-3190

Dagnelie, P. C. and Bell, J. D. and Williams, S. C. and Bates, T. E. and Abel, P. D. and Foster, C. S. (1993) Altered phosphorylation status, phospholipid metabolism and gluconeogenesis in the host liver of rats with prostate cancer: a 31P magnetic resonance spectroscopy study. British Journal of Cancer, 67 (6). pp. 1303-1309. ISSN 0007-0920

Dagnelie, Pieter C. and Bell, Jimmy D. and Williams, Steve C. and Bates, Timothy E. and Abel, Paul D. and Foster, Christopher S. (1994) Effect of fish oil on cancer cachexia and host liver metabolism in rats with prostate tumors. Lipids, 29 (3). pp. 195-203. ISSN 0024-4201

Murphy, Elizabeth J. and Bates, Timothy E. and Williams, Stephen R. and Watson, Tracey and Brindle, Kevin M. and Rajagopalan, Bheeshma and Radda, George K. (1992) Endoplasmic reticulum: the major contributor to the PDE peak in hepatic 31P-NMR spectra at low magnetic field strengths. Biochimica et biophysica acta: biomembranes, 1111 (1). pp. 51-58. ISSN 0005-2736

4 aminobutyric acid

Bonifacio, E. and Christie, M. R. (1996) Tyrosine phosphatase-like proteins as autoantigens in insulin-dependent diabetes mellitus: the targets for 37/40k antibodies. Diabetes, Nutrition and Metabolism - Clinical and Experimental, 9 (4). pp. 183-187. ISSN 0394-3402

AEA

Athanasiou, Andriani and Clarke, Anna B. and Turner, Amy E. and Kumaran, Nethia M. and Vakilpour, Sara and Smith, Paul A. and Bagiokou, Dimitra and Bradshaw, Tracey D. and Westwell, Andrew D. and Fang, Lin and Lobo, Dileep N. and Constantinescu, Cris S. and Calabrese, Vittorio and Loesch, Andrzej and Alexander, Stephen P. H. and Clothier, Richard H. and Kendall, David A. and Bates, Timothy E. (2007) Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications, 364 (1). pp. 131-137. ISSN 0006-291x

AME

Senyuk, Vitalyi and Rinaldi, Ciro Roberto and Li, Donglan and Cattaneo, Francesca and Stojanovic, Aleksandra and Pane, Fabrizio and Du, Xiaoping and Mahmud, Nadim and Dickstein, Jerome and Nucifora, Giuseppina (2009) Consistent up-regulation of Stat3 Independently of Jak2 mutations in a new murine model of essential thrombocythemia. Cancer research, 69 (1). pp. 262-271. ISSN 0008-5472

AMPA

Rosin, Claudia and Bates, Timothy E. and Skaper, Stephen D. (2004) Excitatory amino acid induced oligodendrocyte cell death in vitro: receptor-dependent and -independent mechanisms. Journal of Neurochemistry, 90 (5). pp. 1173-1185. ISSN 0022-3042

ATP

Allen, Kathryn L. and Almeida, Angeles and Bates, Timothy E. and Clark, John B. (1995) Changes of respiratory chain activity in mitochondrial and synaptosomal fractions isolated from the gerbil brain after graded ischaemia. Journal of neurochemistry, 64 (5). pp. 2222-2229. ISSN 0022-3042

Bates, T. E. and Heales, S. J. and Davies, S. E. and Boakye, P. and Clark, J. B. (1994) Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. Journal of neurochemistry, 63 (2). pp. 640-648. ISSN 0022-3042

Adolescent

Wagner, R. and McNally, J. M. and Bonifacio, E. and Genovese, S. and Foulis, A. and McGill, M. and Christie, M. R. and Betterle, C. and Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

Adult

Christie, M. R. and Genovese, S. and Cassidy, D. and Bosi, E. and Brown, T. J. and Lai, M. and Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

Christie, M. R. and Vohra, G. and Champagne, P. and Daneman, D. and Delovitch, T. L. (1990) Distinct antibody specificities to a 64-kD islet cell antigen in Type 1 diabetes as revealed by trypsin treatment. Journal of Experimental Medicine, 172 (3). pp. 789-794. ISSN 0022-1007

Huang, Guo Cai and Zhao, Min and Jones, Peter and Persaud, Shanta and Ramracheya, Reshma and Lobner, Kristian and Christie, Michael R. and Banga, J. Paul and Peakman, Mark and Sirinivsan, Parthi and Rela, Mohammed and Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Morgenthaler, N. G. and Seissler, J. and Achenbach, P. and Glawe, D. and Payton, M. and Meinck, H.-M. and Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Wagner, R. and Genovese, S. and Bosi, E. and Becker, F. and Bingley, P. J. and Bonifacio, E. and Miles, K. A. and Christie, Michael and Bottazzo, G. F. and Gale, E. A. M. (1994) Slow metabolic deterioration towards diabetes in islet cell antibody positive patients with autoimmune polyendocrine disease. Diabetologia, 37 (4). pp. 365-371. ISSN 0012-186X

Zhao, M. and Amiel, S. A. and Christie, Michael R. and Rela, M. and Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Age

Tew, G. and Klonizakis, Markos and Moss, J. and Ruddock, A. D. and Saxton, J. M. and Hodges, G. J. (2011) Reproducibility of cutaneous thermal hyperaemia assessed by laser Doppler flowmetry in young and older adults. Microvascular Research, 81 (2). pp. 177-182. ISSN 0026-2862

Age of Onset

Damanhouri, L. H. and Dromey, J. A. and Christie, Michael R. and Nasrat, H. A. and Ardawi, M. S. M. and Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Desai, M.a and Cull, C.A.b and Horton, V.A.a and Christie, M.R.c and Bonifacio, E.d and Lampasona, V.d and Bingley, P.J.e and Levy, J.C.a and Mackay, I.R.f and Zimmet, P.g and Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Gillespie, Kathleen M. and Bain, Steven C. and Barnett, Anthony H. and Bingley, Polly J. and Christie, Michael R. and Gill, Geoffrey V. and Gale, Edwin A. M. (2004) The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. The Lancet, 364 (9446). pp. 1699-1700. ISSN 0140-6736

Gorus, F. K. and Goubert, P. and Semakula, C. and Vandewalle, C. L. and De Schepper, J. and Scheen, A. and Christie, Michael R. and Pipeleers, D. G. (1997) IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia, 40 (1). pp. 95-99. ISSN 0012-186X

Aged

Hawa, M. and Rowe, R. and Lan, M. S. and Notkins, A. L. and Pozzilli, P. and Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Wagner, R. and Genovese, S. and Bosi, E. and Becker, F. and Bingley, P. J. and Bonifacio, E. and Miles, K. A. and Christie, Michael and Bottazzo, G. F. and Gale, E. A. M. (1994) Slow metabolic deterioration towards diabetes in islet cell antibody positive patients with autoimmune polyendocrine disease. Diabetologia, 37 (4). pp. 365-371. ISSN 0012-186X

Aged, 80 and over

Morgenthaler, N. G. and Seissler, J. and Achenbach, P. and Glawe, D. and Payton, M. and Meinck, H.-M. and Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Wagner, R. and McNally, J. M. and Bonifacio, E. and Genovese, S. and Foulis, A. and McGill, M. and Christie, M. R. and Betterle, C. and Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

Ageing

Tew, G. and Klonizakis, Markos and Saxton, G. (2010) Effects of ageing and fitness on skin-microvessel vasodilator function in humans. European Journal of Applied Physiology, 109 (2). pp. 173-181. ISSN 1439-6319

Aging

Roll, U. and Christie, M. R. and Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

Alleles

Gylling, Mikhail and Tuomi, Tiinamaija and Bjorses, Petra and Kontiainen, Sirkka and Partanen, Jukka and Christie, Michael R. and Knip, Mikael and Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

Allopurinol

Huang, Guo Cai and Zhao, Min and Jones, Peter and Persaud, Shanta and Ramracheya, Reshma and Lobner, Kristian and Christie, Michael R. and Banga, J. Paul and Peakman, Mark and Sirinivsan, Parthi and Rela, Mohammed and Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Alzheimer's

Mancuso, Cesare and Bates, Timothy E. and Butterfield, D. Allan and Calafato, Stella and Cornelius, Carolin and De Lorenzo, Antonino and Dinkova Kostova, Albena T. and Calabrese, Vittorio (2007) Natural antioxidants in Alzheimer's disease. Expert Opinion on Investigational Drugs, 16 (12). pp. 1921-1931. ISSN 1354-3784

Pardon, Marie-Christine and Sarmad, Sarir and Rattray, Ivan and Bates, Timothy E. and Scullion, Gillian A. and Marsden, Charles A. and Barrett, David A. and Lowe, James and Kendall, David A. (2009) Repeated novel cage exposure-induced improvement of early Alzheimer's-like cognitive and amyloid changes in TASTPM mice is unrelated to changes in brain endocannabinoids levels. Neurobiology of Aging, 30 (7). pp. 1099-1113. ISSN 0197-4580

Animal

Christie, M. R. and Vohra, G. and Champagne, P. and Daneman, D. and Delovitch, T. L. (1990) Distinct antibody specificities to a 64-kD islet cell antigen in Type 1 diabetes as revealed by trypsin treatment. Journal of Experimental Medicine, 172 (3). pp. 789-794. ISSN 0022-1007

Christie, Michael and Brown, T. J. and Cassidy, D. (1992) Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme. Diabetologia, 35 (4). pp. 380-384. ISSN 0012-186X

Roll, U. and Christie, M. R. and Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

Animals

Huang, Guo Cai and Zhao, Min and Jones, Peter and Persaud, Shanta and Ramracheya, Reshma and Lobner, Kristian and Christie, Michael R. and Banga, J. Paul and Peakman, Mark and Sirinivsan, Parthi and Rela, Mohammed and Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Piquer, Sandra and Valera, Lionel and Lampasona, Vito and Jardin-Watelet, Benedicte and Roche, Stephanie and Granier, Claude and Roquet, Francoise and Christie, Michael R. and Giordano, Tiziana and Malosio, Maria-Luisa and Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

Zhao, M. and Amiel, S. A. and Christie, Michael R. and Rela, M. and Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Animals, Newborn

Christie, M. R. and Pipeleers, D. G. and Lernmark, A. and Baekkeskov, S. (1990) Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes. Journal of Biological Chemistry, 265 (1). pp. 376-381. ISSN 0021-9258

Christie, M. R. and Vohra, G. and Champagne, P. and Daneman, D. and Delovitch, T. L. (1990) Distinct antibody specificities to a 64-kD islet cell antigen in Type 1 diabetes as revealed by trypsin treatment. Journal of Experimental Medicine, 172 (3). pp. 789-794. ISSN 0022-1007

Antibodies

Christie, M. R. and Daneman, D. and Champagne, P. and Delovitch, T. L. (1990) Persistence of serum antibodies to 64,000-Mr islet cell protein after onset of type I diabetes. Diabetes, 39 (6). pp. 653-656. ISSN 0012-1797

Hawkes, C. J. and Wasmeier, C. and Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Roll, U. and Christie, M. R. and Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

Antibodies, Monoclonal

Piquer, Sandra and Valera, Lionel and Lampasona, Vito and Jardin-Watelet, Benedicte and Roche, Stephanie and Granier, Claude and Roquet, Francoise and Christie, Michael R. and Giordano, Tiziana and Malosio, Maria-Luisa and Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

Wagner, R. and McNally, J. M. and Bonifacio, E. and Genovese, S. and Foulis, A. and McGill, M. and Christie, M. R. and Betterle, C. and Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

Antibody Formation

Roll, U. and Christie, M. R. and Fuchtenbusch, M. and Payton, M. A. and Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Antibody Specificity

Baekkeskov, S. and Warnock, G. and Christie, M. and Rajotte, R.V. and Larsen, P.M. and Fey, S. (1989) Revelation of specificity of 64K autoantibodies in IDDM serums by high-resolution 2-D gel electrophoresis. Unambiguous identification of 64K target antigen. Diabetes, 38 (9). pp. 1133-1141. ISSN 0012-1797

Christie, M. R. and Vohra, G. and Champagne, P. and Daneman, D. and Delovitch, T. L. (1990) Distinct antibody specificities to a 64-kD islet cell antigen in Type 1 diabetes as revealed by trypsin treatment. Journal of Experimental Medicine, 172 (3). pp. 789-794. ISSN 0022-1007

Morgenthaler, N. G. and Löbner, K. and Morgenthaler, U. Y. and Christie, M. R. and Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Morgenthaler, N. G. and Seissler, J. and Achenbach, P. and Glawe, D. and Payton, M. and Meinck, H.-M. and Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Piquer, Sandra and Valera, Lionel and Lampasona, Vito and Jardin-Watelet, Benedicte and Roche, Stephanie and Granier, Claude and Roquet, Francoise and Christie, Michael R. and Giordano, Tiziana and Malosio, Maria-Luisa and Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

Antigen-Antibody Reactions

Hawkes, C. J. and Wasmeier, C. and Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Payton, M. A. and Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Antigens

Christie, M. R. and Tun, R. Y. M. and Lo, S. S. S. and Cassidy, D. and Brown, T. J. and Hollands, J. and Shattock, M. and Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Payton, M. A. and Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Antigens, Surface

Christie, M. R. and Vohra, G. and Champagne, P. and Daneman, D. and Delovitch, T. L. (1990) Distinct antibody specificities to a 64-kD islet cell antigen in Type 1 diabetes as revealed by trypsin treatment. Journal of Experimental Medicine, 172 (3). pp. 789-794. ISSN 0022-1007

Antioxidant

Calabrese, V. and Bates, T. E. and Stella, A. M. (2000) NO synthase and NO-dependent signal pathways in brain aging and neurodegenerative disorders: the role of oxidant/antioxidant balance. Neurochemical Research, 25 (9-10). pp. 1315-41. ISSN 0364-3190

Calabrese, V. and Scapagnini, G. and Catalano, C. and Bates, T. E. and Dinotta, F. and Micali, G. and Giuffrida Stella, A. M. (2001) Induction of heat shock protein synthesis in human skin fibroblasts in response to oxidative stress: regulation by a natural antioxidant from rosemary extract. International Journal of Tissue Reactions, 23 (2). pp. 51-8. ISSN 0250-0868

Antioxidants

Mancuso, Cesare and Bates, Timothy E. and Butterfield, D. Allan and Calafato, Stella and Cornelius, Carolin and De Lorenzo, Antonino and Dinkova Kostova, Albena T. and Calabrese, Vittorio (2007) Natural antioxidants in Alzheimer's disease. Expert Opinion on Investigational Drugs, 16 (12). pp. 1921-1931. ISSN 1354-3784

Arabs

Damanhouri, L. H. and Dromey, J. A. and Christie, Michael R. and Nasrat, H. A. and Ardawi, M. S. M. and Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Autoantibodies

Baekkeskov, S. and Warnock, G. and Christie, M. and Rajotte, R.V. and Larsen, P.M. and Fey, S. (1989) Revelation of specificity of 64K autoantibodies in IDDM serums by high-resolution 2-D gel electrophoresis. Unambiguous identification of 64K target antigen. Diabetes, 38 (9). pp. 1133-1141. ISSN 0012-1797

Bearzatto, Massimo and Naserke, Heike and Piquer, Sandra and Koczwara, Kerstin and Lampasona, Vito and Williams, Alistair and Christie, Michael R. and Bingley, Polly J. and Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Bingley, P. J. and Christie, M. R. and Bonifacio, E. and Bonfanti, R. and Shattock, M. and Fonte, M.-T. and Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Bottazzo, G. F. and Genovese, S. and Bosi, E. and Dean, B. M. and Christie, M. R. and Bonifacio, E. (1991) Novel considerations on the antibody/autoantigen system in type I (insulin-dependent) diabetes mellitus. Annals of Medicine, 23 (4). pp. 453-461. ISSN 0785-3890

Christie, M. R. (1993) Characterization of distinct islet protein auto antigens associated with type 1 diabetes. Autoimmunity, 15 (s1). pp. 1-3. ISSN 0891-6934

Christie, M. R. and Genovese, S. and Cassidy, D. and Bosi, E. and Brown, T. J. and Lai, M. and Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

Christie, M. R. and Hollands, J. A. and Brown, T. J. and Michelsen, B. K. and Delovitch, T. L. (1993) Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. Journal of Clinical Investigation, 92 (1). pp. 240-248. ISSN 0021-9738

Christie, M. R. and Tun, R. Y. M. and Lo, S. S. S. and Cassidy, D. and Brown, T. J. and Hollands, J. and Shattock, M. and Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Christie, M. R. and Vohra, G. and Champagne, P. and Daneman, D. and Delovitch, T. L. (1990) Distinct antibody specificities to a 64-kD islet cell antigen in Type 1 diabetes as revealed by trypsin treatment. Journal of Experimental Medicine, 172 (3). pp. 789-794. ISSN 0022-1007

Christie, Michael and Brown, T. J. and Cassidy, D. (1992) Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme. Diabetologia, 35 (4). pp. 380-384. ISSN 0012-186X

Christie, Michael and Landin-Olsson, M. and Sundkvist, G. and Dahlquist, G. and Lernmark, A. and Baekkeskov, S. (1988) Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes. Diabetologia, 31 (8). pp. 597-602. ISSN 0012-186X

Christie, Michael R. and Molvig, Jens and Hawkes, Charlotte J. and Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

Christie, Michael R. and Roll, Ursula and Payton, Mark A. and Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Damanhouri, L. H. and Dromey, J. A. and Christie, Michael R. and Nasrat, H. A. and Ardawi, M. S. M. and Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Desai, M.a and Cull, C.A.b and Horton, V.A.a and Christie, M.R.c and Bonifacio, E.d and Lampasona, V.d and Bingley, P.J.e and Levy, J.C.a and Mackay, I.R.f and Zimmet, P.g and Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Gorus, F. K. and Goubert, P. and Semakula, C. and Vandewalle, C. L. and De Schepper, J. and Scheen, A. and Christie, Michael R. and Pipeleers, D. G. (1997) IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia, 40 (1). pp. 95-99. ISSN 0012-186X

Gylling, Mikhail and Tuomi, Tiinamaija and Bjorses, Petra and Kontiainen, Sirkka and Partanen, Jukka and Christie, Michael R. and Knip, Mikael and Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

Hatfield, E. C. I. and Hawkes, C. J. and Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Hawa, M. and Rowe, R. and Lan, M. S. and Notkins, A. L. and Pozzilli, P. and Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Hawkes, C. J. and Wasmeier, C. and Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Lampeter, E. F. and Kolb, H. and Seifert, I. and Lohmann, D. and Heise, J. W. and Bertrams, J. and Christie, Michael and Kolb-Bachofen, V. (1994) Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity. Diabetologia, 37 (5). pp. 471-475. ISSN 0012-186X

Morgenthaler, N. G. and Löbner, K. and Morgenthaler, U. Y. and Christie, M. R. and Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Morgenthaler, N. G. and Seissler, J. and Achenbach, P. and Glawe, D. and Payton, M. and Meinck, H.-M. and Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Piquer, Sandra and Valera, Lionel and Lampasona, Vito and Jardin-Watelet, Benedicte and Roche, Stephanie and Granier, Claude and Roquet, Francoise and Christie, Michael R. and Giordano, Tiziana and Malosio, Maria-Luisa and Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

Roll, U. and Christie, M. R. and Fuchtenbusch, M. and Payton, M. A. and Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Roll, U. and Christie, M. R. and Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

Seissler, J. and Morgenthaler, N. G. and Achenbach, P. and Lampeter, E .F. and Glawe, D. and Payton, M. and Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

Tremble, Jennifer and Morgenthaler, Nils G. and Vlug, Arjen and Powers, Alvin C. and Christie, Michael R. and Scherbaum, Werner A. and Banga, J. Paul (1997) Human B cells secreting immunoglobulin G to glutamic acid decarboxylase- 65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes. Journal of Clinical Endocrinology and Metabolism, 82 (8). pp. 2664-2670. ISSN 0021-972X

Wagner, R. and Genovese, S. and Bosi, E. and Becker, F. and Bingley, P. J. and Bonifacio, E. and Miles, K. A. and Christie, Michael and Bottazzo, G. F. and Gale, E. A. M. (1994) Slow metabolic deterioration towards diabetes in islet cell antibody positive patients with autoimmune polyendocrine disease. Diabetologia, 37 (4). pp. 365-371. ISSN 0012-186X

Wagner, R. and McNally, J. M. and Bonifacio, E. and Genovese, S. and Foulis, A. and McGill, M. and Christie, M. R. and Betterle, C. and Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

Winnock, Frederic and Christie, Michael R. and Batstra, Manou R. and Aanstoot, Henk-Jan and Weets, Ilse and Decochez, Katelijn and Jopart, Philippe and Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

Autoantigens

Bearzatto, Massimo and Naserke, Heike and Piquer, Sandra and Koczwara, Kerstin and Lampasona, Vito and Williams, Alistair and Christie, Michael R. and Bingley, Polly J. and Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Bonifacio, E. and Christie, M. R. (1997) Islet cell antigens in the prediction and prevention of insulin-dependent diabetes mellitus. Annals of Medicine, 29 (5). pp. 405-412. ISSN 0785-3890

Bottazzo, G. F. and Genovese, S. and Bosi, E. and Dean, B. M. and Christie, M. R. and Bonifacio, E. (1991) Novel considerations on the antibody/autoantigen system in type I (insulin-dependent) diabetes mellitus. Annals of Medicine, 23 (4). pp. 453-461. ISSN 0785-3890

Christie, M. R. (1993) Characterization of distinct islet protein auto antigens associated with type 1 diabetes. Autoimmunity, 15 (s1). pp. 1-3. ISSN 0891-6934

Christie, M. R. (1996) Islet cell autoantigens in type 1 diabetes. European Journal of Clinical Investigation, 26 (10). pp. 827-838. ISSN 0014-2972

Christie, M. R. and Genovese, S. and Cassidy, D. and Bosi, E. and Brown, T. J. and Lai, M. and Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

Christie, M. R. and Hollands, J. A. and Brown, T. J. and Michelsen, B. K. and Delovitch, T. L. (1993) Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. Journal of Clinical Investigation, 92 (1). pp. 240-248. ISSN 0021-9738

Christie, M. R. and Pipeleers, D. G. and Lernmark, A. and Baekkeskov, S. (1990) Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes. Journal of Biological Chemistry, 265 (1). pp. 376-381. ISSN 0021-9258

Christie, M. R. and Tun, R. Y. M. and Lo, S. S. S. and Cassidy, D. and Brown, T. J. and Hollands, J. and Shattock, M. and Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Christie, Michael and Landin-Olsson, M. and Sundkvist, G. and Dahlquist, G. and Lernmark, A. and Baekkeskov, S. (1988) Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes. Diabetologia, 31 (8). pp. 597-602. ISSN 0012-186X

Christie, Michael R. and Roll, Ursula and Payton, Mark A. and Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Hatfield, E. C. I. and Hawkes, C. J. and Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Hawa, M. and Rowe, R. and Lan, M. S. and Notkins, A. L. and Pozzilli, P. and Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Hawkes, C. J. and Schloot, N. C. and Marks, J. and Willemen, S. J. M. and Drijfhout, J. W. and Mayer, E. K. and Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

Hawkes, C. J. and Wasmeier, C. and Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Morgenthaler, N. G. and Löbner, K. and Morgenthaler, U. Y. and Christie, M. R. and Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Morgenthaler, N. G. and Seissler, J. and Achenbach, P. and Glawe, D. and Payton, M. and Meinck, H.-M. and Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Piquer, Sandra and Valera, Lionel and Lampasona, Vito and Jardin-Watelet, Benedicte and Roche, Stephanie and Granier, Claude and Roquet, Francoise and Christie, Michael R. and Giordano, Tiziana and Malosio, Maria-Luisa and Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

Autoimmune Diseases

Bottazzo, G. F. and Genovese, S. and Bosi, E. and Dean, B. M. and Christie, M. R. and Bonifacio, E. (1991) Novel considerations on the antibody/autoantigen system in type I (insulin-dependent) diabetes mellitus. Annals of Medicine, 23 (4). pp. 453-461. ISSN 0785-3890

Christie, M. R. (1993) Characterization of distinct islet protein auto antigens associated with type 1 diabetes. Autoimmunity, 15 (s1). pp. 1-3. ISSN 0891-6934

Damanhouri, L. H. and Dromey, J. A. and Christie, Michael R. and Nasrat, H. A. and Ardawi, M. S. M. and Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Morgenthaler, N. G. and Seissler, J. and Achenbach, P. and Glawe, D. and Payton, M. and Meinck, H.-M. and Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Autoimmunity

McLaughlin, Kerry A. and Richardson, Carolyn C. and Williams, Stefan and Bonifacio, Ezio and Morgan, Diana and Feltbower, Richard G. and Powell, Michael and Rees Smith, Bernard and Furmaniak, Jadwiga and Christie, Michael R. (2015) Relationships between major epitopes of the IA-2 autoantigen in Type 1 diabetes: implications for determinant spreading. Clinical Immunology, 160 (2). pp. 226-236. ISSN 1521-6616

Autoradiography

Christie, M. R. and Daneman, D. and Champagne, P. and Delovitch, T. L. (1990) Persistence of serum antibodies to 64,000-Mr islet cell protein after onset of type I diabetes. Diabetes, 39 (6). pp. 653-656. ISSN 0012-1797

Azo Compounds

Hansen, W.A. and Christie, M.R. and Kahn, R. and Norgaard, A. and Abel, I. and Petersen, A.M. and Jorgensen, D.W. and Baekkeskov, S. and Nielsen, J.H. and Lernmark, A. and Egeberg, J. and Richter-Olesen, H. and Grainger, T. and Kristensen, J.K. and Brynitz, S. and Bilde, T. (1989) Supravital dithizone staining in the isolation of human and rat pancreatic islets. Diabetes Research, 10 (2). pp. 53-57. ISSN 0265-5985

B lymphocyte

Bearzatto, Massimo and Naserke, Heike and Piquer, Sandra and Koczwara, Kerstin and Lampasona, Vito and Williams, Alistair and Christie, Michael R. and Bingley, Polly J. and Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

BAY 57-1293

Biswas, Subhajit and Nunez Miguel, Ricardo and Sukla, Soumi and Field, Hugh J. (2009) A mutation in helicase motif IV of herpes simplex virus type 1 UL5 that results in reduced growth in vitro and lower virulence in a murine infection model is related to the predicted helicase structure. Journal of General Virology, 90 (8). pp. 1937-1942. ISSN 0022-1317

BSO

Heales, S. J. and Davies, S. E. and Bates, T. E. and Clark, J. B. (1995) Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration. Neurochemical research, 20 (1). pp. 31-38. ISSN 0364-3190

BV2

Moss, David W. and Bates, Timothy E. (2001) Activation of murine microglial cell lines by lipopolysaccharide and interferon-gamma causes NO-mediated decreases in mitochondrial and cellular function. The European Journal of Neuroscience, 13 (3). pp. 529-38. ISSN 0953-816X

Base Sequence

Payton, M. A. and Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Belgium

Gorus, F. K. and Goubert, P. and Semakula, C. and Vandewalle, C. L. and De Schepper, J. and Scheen, A. and Christie, Michael R. and Pipeleers, D. G. (1997) IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia, 40 (1). pp. 95-99. ISSN 0012-186X

Winnock, Frederic and Christie, Michael R. and Batstra, Manou R. and Aanstoot, Henk-Jan and Weets, Ilse and Decochez, Katelijn and Jopart, Philippe and Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

Binding Sites, Antibody

Bearzatto, Massimo and Naserke, Heike and Piquer, Sandra and Koczwara, Kerstin and Lampasona, Vito and Williams, Alistair and Christie, Michael R. and Bingley, Polly J. and Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Binding, Competitive

Bearzatto, Massimo and Naserke, Heike and Piquer, Sandra and Koczwara, Kerstin and Lampasona, Vito and Williams, Alistair and Christie, Michael R. and Bingley, Polly J. and Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Christie, M. R. and Hollands, J. A. and Brown, T. J. and Michelsen, B. K. and Delovitch, T. L. (1993) Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. Journal of Clinical Investigation, 92 (1). pp. 240-248. ISSN 0021-9738

Hatfield, E. C. I. and Hawkes, C. J. and Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Biological Markers

Bonifacio, E. and Christie, M. R. (1997) Islet cell antigens in the prediction and prevention of insulin-dependent diabetes mellitus. Annals of Medicine, 29 (5). pp. 405-412. ISSN 0785-3890

Christie, M. R. (1993) Characterization of distinct islet protein auto antigens associated with type 1 diabetes. Autoimmunity, 15 (s1). pp. 1-3. ISSN 0891-6934

Christie, M. R. and Genovese, S. and Cassidy, D. and Bosi, E. and Brown, T. J. and Lai, M. and Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

Christie, M. R. and Tun, R. Y. M. and Lo, S. S. S. and Cassidy, D. and Brown, T. J. and Hollands, J. and Shattock, M. and Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Damanhouri, L. H. and Dromey, J. A. and Christie, Michael R. and Nasrat, H. A. and Ardawi, M. S. M. and Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Gorus, F. K. and Goubert, P. and Semakula, C. and Vandewalle, C. L. and De Schepper, J. and Scheen, A. and Christie, Michael R. and Pipeleers, D. G. (1997) IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia, 40 (1). pp. 95-99. ISSN 0012-186X

Hawa, M. and Rowe, R. and Lan, M. S. and Notkins, A. L. and Pozzilli, P. and Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Lampeter, E. F. and Kolb, H. and Seifert, I. and Lohmann, D. and Heise, J. W. and Bertrams, J. and Christie, Michael and Kolb-Bachofen, V. (1994) Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity. Diabetologia, 37 (5). pp. 471-475. ISSN 0012-186X

Seissler, J. and Morgenthaler, N. G. and Achenbach, P. and Lampeter, E .F. and Glawe, D. and Payton, M. and Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

Zhao, M. and Amiel, S. A. and Christie, Michael R. and Rela, M. and Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Blood Glucose

Huang, Guo Cai and Zhao, Min and Jones, Peter and Persaud, Shanta and Ramracheya, Reshma and Lobner, Kristian and Christie, Michael R. and Banga, J. Paul and Peakman, Mark and Sirinivsan, Parthi and Rela, Mohammed and Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Wagner, R. and Genovese, S. and Bosi, E. and Becker, F. and Bingley, P. J. and Bonifacio, E. and Miles, K. A. and Christie, Michael and Bottazzo, G. F. and Gale, E. A. M. (1994) Slow metabolic deterioration towards diabetes in islet cell antibody positive patients with autoimmune polyendocrine disease. Diabetologia, 37 (4). pp. 365-371. ISSN 0012-186X

Body Mass Index

Desai, M.a and Cull, C.A.b and Horton, V.A.a and Christie, M.R.c and Bonifacio, E.d and Lampasona, V.d and Bingley, P.J.e and Levy, J.C.a and Mackay, I.R.f and Zimmet, P.g and Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Brain

Allen, Kathryn L. and Almeida, Angeles and Bates, Timothy E. and Clark, John B. (1995) Changes of respiratory chain activity in mitochondrial and synaptosomal fractions isolated from the gerbil brain after graded ischaemia. Journal of neurochemistry, 64 (5). pp. 2222-2229. ISSN 0022-3042

Almeida, A. and Brooks, K. J. and Sammut, I. and Keelan, J. and Davey, G. P. and Clark, J. B. and Bates, T. E. (1995) Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain. Developmental neuroscience, 17 (4). pp. 212-218. ISSN 0378-5866

Bakken, Inger J. and Sonnewald, Ursula and Clark, John B. and Bates, Timothy E. (1997) [U-13C]glutamate metabolism in rat brain mitochondria reveals malic enzyme activity. Neuroreport, 8 (7). pp. 1567-1570. ISSN 0959-4965

Bates, T. E and Loesch, A. and Burnstock, G. and Clark, J. B. (1995) Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver. Biochemical and biophysical research communications, 213 (3). pp. 896-900. ISSN 0006-291X

Bates, T. E. and Heales, S. J. and Davies, S. E. and Boakye, P. and Clark, J. B. (1994) Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. Journal of neurochemistry, 63 (2). pp. 640-648. ISSN 0022-3042

Bates, Timothy E. and Strangward, Maria and Keelan, Julia and Davey, Gavin P. and Munro, Peter M. G. and Clark, John B. (1996) Inhibition of N-acetylaspartate production: implications for 1H MRS studies in vivo. Neuroreport, 7 (8). pp. 1397-1400. ISSN 0959-4965

Christie, M. R. and Genovese, S. and Cassidy, D. and Bosi, E. and Brown, T. J. and Lai, M. and Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

Christie, M. R. and Hollands, J. A. and Brown, T. J. and Michelsen, B. K. and Delovitch, T. L. (1993) Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. Journal of Clinical Investigation, 92 (1). pp. 240-248. ISSN 0021-9738

Heales, S. J. and Davies, S. E. and Bates, T. E. and Clark, J. B. (1995) Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration. Neurochemical research, 20 (1). pp. 31-38. ISSN 0364-3190

Keelan, Julie and Bates, Timothy E. and Clark, John B. (1996) Intrasynaptosomal free calcium concentration during rat brain development: effects of hypoxia, aglycaemia, and ischaemia. Journal of neurochemistry, 66 (6). pp. 2460-7. ISSN 0022-3042

Payton, M. A. and Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Roll, U. and Christie, M. R. and Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

Brain Chemistry

Christie, M. R. (1993) Characterization of distinct islet protein auto antigens associated with type 1 diabetes. Autoimmunity, 15 (s1). pp. 1-3. ISSN 0891-6934

Brain Slices

Brooks, Keith J. and Hargreaves, Iain P. and Bates, Timothy E. (2008) Protection of respiratory chain enzymes from ischaemic damage in adult rat brain slices. Neurochemical research, 33 (9). pp. 1711-1716. ISSN 0364-3190

Brain Tumour

Levicar, Natasa and Dewey, Ricardo A. and Daley, Emma and Bates, Timothy E. and Davies, Derek and Kos, Janko and Pilkington, Geoffrey J. and Lah, Tamara T. (2003) Selective suppression of cathepsin L by antisense cDNA impairs human brain tumor cell invasion in vitro and promotes apoptosis. Cancer Gene Therapy, 10 (2). pp. 141-51. ISSN 0929-1903

C peptide

Christie, Michael R. and Molvig, Jens and Hawkes, Charlotte J. and Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

C-Peptide

Christie, M. R. and Daneman, D. and Champagne, P. and Delovitch, T. L. (1990) Persistence of serum antibodies to 64,000-Mr islet cell protein after onset of type I diabetes. Diabetes, 39 (6). pp. 653-656. ISSN 0012-1797

Christie, Michael R. and Molvig, Jens and Hawkes, Charlotte J. and Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

Ca2+

Keelan, Julie and Bates, Timothy E. and Clark, John B. (1996) Intrasynaptosomal free calcium concentration during rat brain development: effects of hypoxia, aglycaemia, and ischaemia. Journal of neurochemistry, 66 (6). pp. 2460-7. ISSN 0022-3042

Calcium

Keelan, Julie and Bates, Timothy E. and Clark, John B. (1996) Intrasynaptosomal free calcium concentration during rat brain development: effects of hypoxia, aglycaemia, and ischaemia. Journal of neurochemistry, 66 (6). pp. 2460-7. ISSN 0022-3042

Cancer

Dagnelie, Pieter C. and Bell, Jimmy D. and Williams, Steve C. and Bates, Timothy E. and Abel, Paul D. and Foster, Christopher S. (1994) Effect of fish oil on cancer cachexia and host liver metabolism in rats with prostate tumors. Lipids, 29 (3). pp. 195-203. ISSN 0024-4201

Carbohydrates

Payton, M. A. and Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Cathepsin

Levicar, Natasa and Dewey, Ricardo A. and Daley, Emma and Bates, Timothy E. and Davies, Derek and Kos, Janko and Pilkington, Geoffrey J. and Lah, Tamara T. (2003) Selective suppression of cathepsin L by antisense cDNA impairs human brain tumor cell invasion in vitro and promotes apoptosis. Cancer Gene Therapy, 10 (2). pp. 141-51. ISSN 0929-1903

Cell Fractionation

Christie, M. R. and Pipeleers, D. G. and Lernmark, A. and Baekkeskov, S. (1990) Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes. Journal of Biological Chemistry, 265 (1). pp. 376-381. ISSN 0021-9258

Cell Line

Hawkes, C. J. and Schloot, N. C. and Marks, J. and Willemen, S. J. M. and Drijfhout, J. W. and Mayer, E. K. and Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

Cell Membrane

Christie, M. R. and Pipeleers, D. G. and Lernmark, A. and Baekkeskov, S. (1990) Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes. Journal of Biological Chemistry, 265 (1). pp. 376-381. ISSN 0021-9258

Christie, M. R. and Vohra, G. and Champagne, P. and Daneman, D. and Delovitch, T. L. (1990) Distinct antibody specificities to a 64-kD islet cell antigen in Type 1 diabetes as revealed by trypsin treatment. Journal of Experimental Medicine, 172 (3). pp. 789-794. ISSN 0022-1007

Cell Proliferation

Zhao, M. and Amiel, S. A. and Christie, Michael R. and Rela, M. and Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Cell Transplantation

Zhao, M. and Amiel, S. A. and Christie, Michael R. and Rela, M. and Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Cells, Cultured

Hansen, W.A. and Christie, M.R. and Kahn, R. and Norgaard, A. and Abel, I. and Petersen, A.M. and Jorgensen, D.W. and Baekkeskov, S. and Nielsen, J.H. and Lernmark, A. and Egeberg, J. and Richter-Olesen, H. and Grainger, T. and Kristensen, J.K. and Brynitz, S. and Bilde, T. (1989) Supravital dithizone staining in the isolation of human and rat pancreatic islets. Diabetes Research, 10 (2). pp. 53-57. ISSN 0265-5985

Zhao, M. and Amiel, S. A. and Christie, Michael R. and Rela, M. and Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Zhao, M. and Christie, M.R. and Heaton, N. and George, S. and Amiel, S. and Huang, G.C. (2002) Amelioration of streptozotocin-induced diabetes in mice using human islet cells derived from long-term culture in vitro. Transplantation, 73 (9). pp. 1454-1460. ISSN 0041-1337

Cellular stress response

Calabrese, Vittorio and Cornelius, Carolin and Mancuso, Cesare and Pennisi, Giovanni and Calafato, Stella and Bellia, Francesco and Bates, Timothy E. and Giuffrida Stella, Anna Maria and Schapira, Tony and Dinkova Kostova, Albena T. and Rizzarelli, Enrico (2008) Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity. Neurochemical Research, 33 (12). pp. 2444-2471. ISSN 0364-3190

Centrifugation, Density Gradient

Christie, M. R. and Pipeleers, D. G. and Lernmark, A. and Baekkeskov, S. (1990) Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes. Journal of Biological Chemistry, 265 (1). pp. 376-381. ISSN 0021-9258

Child

Christie, M. R. and Daneman, D. and Champagne, P. and Delovitch, T. L. (1990) Persistence of serum antibodies to 64,000-Mr islet cell protein after onset of type I diabetes. Diabetes, 39 (6). pp. 653-656. ISSN 0012-1797

Christie, M. R. and Genovese, S. and Cassidy, D. and Bosi, E. and Brown, T. J. and Lai, M. and Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

Christie, M. R. and Tun, R. Y. M. and Lo, S. S. S. and Cassidy, D. and Brown, T. J. and Hollands, J. and Shattock, M. and Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Christie, M. R. and Vohra, G. and Champagne, P. and Daneman, D. and Delovitch, T. L. (1990) Distinct antibody specificities to a 64-kD islet cell antigen in Type 1 diabetes as revealed by trypsin treatment. Journal of Experimental Medicine, 172 (3). pp. 789-794. ISSN 0022-1007

Gillespie, Kathleen M. and Bain, Steven C. and Barnett, Anthony H. and Bingley, Polly J. and Christie, Michael R. and Gill, Geoffrey V. and Gale, Edwin A. M. (2004) The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. The Lancet, 364 (9446). pp. 1699-1700. ISSN 0140-6736

Morgenthaler, N. G. and Seissler, J. and Achenbach, P. and Glawe, D. and Payton, M. and Meinck, H.-M. and Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Child, Preschool

Bingley, P. J. and Christie, M. R. and Bonifacio, E. and Bonfanti, R. and Shattock, M. and Fonte, M.-T. and Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Christie, M. R. and Genovese, S. and Cassidy, D. and Bosi, E. and Brown, T. J. and Lai, M. and Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

Christie, M. R. and Vohra, G. and Champagne, P. and Daneman, D. and Delovitch, T. L. (1990) Distinct antibody specificities to a 64-kD islet cell antigen in Type 1 diabetes as revealed by trypsin treatment. Journal of Experimental Medicine, 172 (3). pp. 789-794. ISSN 0022-1007

Christie, Michael R. and Roll, Ursula and Payton, Mark A. and Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Gillespie, Kathleen M. and Bain, Steven C. and Barnett, Anthony H. and Bingley, Polly J. and Christie, Michael R. and Gill, Geoffrey V. and Gale, Edwin A. M. (2004) The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. The Lancet, 364 (9446). pp. 1699-1700. ISSN 0140-6736

Gorus, F. K. and Goubert, P. and Semakula, C. and Vandewalle, C. L. and De Schepper, J. and Scheen, A. and Christie, Michael R. and Pipeleers, D. G. (1997) IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia, 40 (1). pp. 95-99. ISSN 0012-186X

Gylling, Mikhail and Tuomi, Tiinamaija and Bjorses, Petra and Kontiainen, Sirkka and Partanen, Jukka and Christie, Michael R. and Knip, Mikael and Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

Hatfield, E. C. I. and Hawkes, C. J. and Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Hawa, M. and Rowe, R. and Lan, M. S. and Notkins, A. L. and Pozzilli, P. and Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Hawkes, C. J. and Schloot, N. C. and Marks, J. and Willemen, S. J. M. and Drijfhout, J. W. and Mayer, E. K. and Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

Morgenthaler, N. G. and Löbner, K. and Morgenthaler, U. Y. and Christie, M. R. and Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Morgenthaler, N. G. and Seissler, J. and Achenbach, P. and Glawe, D. and Payton, M. and Meinck, H.-M. and Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Roll, U. and Christie, M. R. and Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

Seissler, J. and Morgenthaler, N. G. and Achenbach, P. and Lampeter, E .F. and Glawe, D. and Payton, M. and Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

Winnock, Frederic and Christie, Michael R. and Batstra, Manou R. and Aanstoot, Henk-Jan and Weets, Ilse and Decochez, Katelijn and Jopart, Philippe and Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

Chronic Disease

Lampeter, E. F. and Kolb, H. and Seifert, I. and Lohmann, D. and Heise, J. W. and Bertrams, J. and Christie, Michael and Kolb-Bachofen, V. (1994) Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity. Diabetologia, 37 (5). pp. 471-475. ISSN 0012-186X

Clinical application

Klonizakis, Markos and Manning, Gillian and Donnelly, Richard (2011) Assessment of lower limb microcirculation: exploring the reproducibility and clinical application of laser doppler techniques. Skin Pharmacology and Physiology: Journal of Pharmacological and Biophysical Research, 24 (3). pp. 136-143. ISSN 1660-5527

Cloning, Molecular

Hawkes, C. J. and Wasmeier, C. and Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Payton, M. A. and Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Cohort Studies

Christie, M. R. and Tun, R. Y. M. and Lo, S. S. S. and Cassidy, D. and Brown, T. J. and Hollands, J. and Shattock, M. and Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Gorus, F. K. and Goubert, P. and Semakula, C. and Vandewalle, C. L. and De Schepper, J. and Scheen, A. and Christie, Michael R. and Pipeleers, D. G. (1997) IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia, 40 (1). pp. 95-99. ISSN 0012-186X

Hawa, M. and Rowe, R. and Lan, M. S. and Notkins, A. L. and Pozzilli, P. and Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Comparative Study

Christie, M. R. (1993) Characterization of distinct islet protein auto antigens associated with type 1 diabetes. Autoimmunity, 15 (s1). pp. 1-3. ISSN 0891-6934

Christie, M. R. and Daneman, D. and Champagne, P. and Delovitch, T. L. (1990) Persistence of serum antibodies to 64,000-Mr islet cell protein after onset of type I diabetes. Diabetes, 39 (6). pp. 653-656. ISSN 0012-1797

Christie, M. R. and Tun, R. Y. M. and Lo, S. S. S. and Cassidy, D. and Brown, T. J. and Hollands, J. and Shattock, M. and Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Payton, M. A. and Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Complex I

Bates, T. E. and Heales, S. J. and Davies, S. E. and Boakye, P. and Clark, J. B. (1994) Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. Journal of neurochemistry, 63 (2). pp. 640-648. ISSN 0022-3042

Complexes

Heales, S. J. and Davies, S. E. and Bates, T. E. and Clark, J. B. (1995) Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration. Neurochemical research, 20 (1). pp. 31-38. ISSN 0364-3190

Cross Reactions

Hatfield, E. C. I. and Hawkes, C. J. and Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Hawkes, C. J. and Wasmeier, C. and Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Cross-Sectional Studies

Hawa, M. and Rowe, R. and Lan, M. S. and Notkins, A. L. and Pozzilli, P. and Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Cyclosporine

Christie, Michael R. and Molvig, Jens and Hawkes, Charlotte J. and Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

Cytoplasm

Hawkes, C. J. and Schloot, N. C. and Marks, J. and Willemen, S. J. M. and Drijfhout, J. W. and Mayer, E. K. and Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

Morgenthaler, N. G. and Seissler, J. and Achenbach, P. and Glawe, D. and Payton, M. and Meinck, H.-M. and Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

D2 receptor

Rosin, Claudia and Colombo, Sergio and Calver, Andrew A. and Bates, Timothy E. and Skaper, Stephen D. (2005) Dopamine D2 and D3 receptor agonists limit oligodendrocyte injury caused by glutamate oxidative stress and oxygen/glucose deprivation. Glia, 52 (4). pp. 336-343. ISSN 0894-1491

D3 receptor

Rosin, Claudia and Colombo, Sergio and Calver, Andrew A. and Bates, Timothy E. and Skaper, Stephen D. (2005) Dopamine D2 and D3 receptor agonists limit oligodendrocyte injury caused by glutamate oxidative stress and oxygen/glucose deprivation. Glia, 52 (4). pp. 336-343. ISSN 0894-1491

DNA Primers

Payton, M. A. and Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Decision Trees

Bingley, P. J. and Christie, M. R. and Bonifacio, E. and Bonfanti, R. and Shattock, M. and Fonte, M.-T. and Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Delta-9-tetrahydrocannabinol

Athanasiou, Andriani and Clarke, Anna B. and Turner, Amy E. and Kumaran, Nethia M. and Vakilpour, Sara and Smith, Paul A. and Bagiokou, Dimitra and Bradshaw, Tracey D. and Westwell, Andrew D. and Fang, Lin and Lobo, Dileep N. and Constantinescu, Cris S. and Calabrese, Vittorio and Loesch, Andrzej and Alexander, Stephen P. H. and Clothier, Richard H. and Kendall, David A. and Bates, Timothy E. (2007) Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications, 364 (1). pp. 131-137. ISSN 0006-291x

Development

Almeida, A. and Brooks, K. J. and Sammut, I. and Keelan, J. and Davey, G. P. and Clark, J. B. and Bates, T. E. (1995) Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain. Developmental neuroscience, 17 (4). pp. 212-218. ISSN 0378-5866

Keelan, Julie and Bates, Timothy E. and Clark, John B. (1996) Intrasynaptosomal free calcium concentration during rat brain development: effects of hypoxia, aglycaemia, and ischaemia. Journal of neurochemistry, 66 (6). pp. 2460-7. ISSN 0022-3042

Diabetes

Christie, Michael (1999) Islet proteins implicated in pathogenesis of type 1 diabetes mellitus. Advances in Molecular and Cell Biology, 29 (C). pp. 75-100. ISSN 1569-2558

Diabetes Mellitus

Damanhouri, L. H. and Dromey, J. A. and Christie, Michael R. and Nasrat, H. A. and Ardawi, M. S. M. and Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Diabetes Mellitus, Experimental

Huang, Guo Cai and Zhao, Min and Jones, Peter and Persaud, Shanta and Ramracheya, Reshma and Lobner, Kristian and Christie, Michael R. and Banga, J. Paul and Peakman, Mark and Sirinivsan, Parthi and Rela, Mohammed and Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Zhao, M. and Amiel, S. A. and Christie, Michael R. and Rela, M. and Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Zhao, M. and Christie, M.R. and Heaton, N. and George, S. and Amiel, S. and Huang, G.C. (2002) Amelioration of streptozotocin-induced diabetes in mice using human islet cells derived from long-term culture in vitro. Transplantation, 73 (9). pp. 1454-1460. ISSN 0041-1337

Diabetes Mellitus, Insulin-Dependent

Baekkeskov, S. and Warnock, G. and Christie, M. and Rajotte, R.V. and Larsen, P.M. and Fey, S. (1989) Revelation of specificity of 64K autoantibodies in IDDM serums by high-resolution 2-D gel electrophoresis. Unambiguous identification of 64K target antigen. Diabetes, 38 (9). pp. 1133-1141. ISSN 0012-1797

Bottazzo, G. F. and Genovese, S. and Bosi, E. and Dean, B. M. and Christie, M. R. and Bonifacio, E. (1991) Novel considerations on the antibody/autoantigen system in type I (insulin-dependent) diabetes mellitus. Annals of Medicine, 23 (4). pp. 453-461. ISSN 0785-3890

Christie, M. R. (1993) Characterization of distinct islet protein auto antigens associated with type 1 diabetes. Autoimmunity, 15 (s1). pp. 1-3. ISSN 0891-6934

Christie, M. R. and Daneman, D. and Champagne, P. and Delovitch, T. L. (1990) Persistence of serum antibodies to 64,000-Mr islet cell protein after onset of type I diabetes. Diabetes, 39 (6). pp. 653-656. ISSN 0012-1797

Christie, M. R. and Genovese, S. and Cassidy, D. and Bosi, E. and Brown, T. J. and Lai, M. and Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

Christie, M. R. and Hollands, J. A. and Brown, T. J. and Michelsen, B. K. and Delovitch, T. L. (1993) Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. Journal of Clinical Investigation, 92 (1). pp. 240-248. ISSN 0021-9738

Christie, M. R. and Pipeleers, D. G. and Lernmark, A. and Baekkeskov, S. (1990) Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes. Journal of Biological Chemistry, 265 (1). pp. 376-381. ISSN 0021-9258

Christie, M. R. and Tun, R. Y. M. and Lo, S. S. S. and Cassidy, D. and Brown, T. J. and Hollands, J. and Shattock, M. and Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Christie, M. R. and Vohra, G. and Champagne, P. and Daneman, D. and Delovitch, T. L. (1990) Distinct antibody specificities to a 64-kD islet cell antigen in Type 1 diabetes as revealed by trypsin treatment. Journal of Experimental Medicine, 172 (3). pp. 789-794. ISSN 0022-1007

Christie, Michael and Brown, T. J. and Cassidy, D. (1992) Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme. Diabetologia, 35 (4). pp. 380-384. ISSN 0012-186X

Christie, Michael and Landin-Olsson, M. and Sundkvist, G. and Dahlquist, G. and Lernmark, A. and Baekkeskov, S. (1988) Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes. Diabetologia, 31 (8). pp. 597-602. ISSN 0012-186X

Payton, M. A. and Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Roll, U. and Christie, M. R. and Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

Wagner, R. and Genovese, S. and Bosi, E. and Becker, F. and Bingley, P. J. and Bonifacio, E. and Miles, K. A. and Christie, Michael and Bottazzo, G. F. and Gale, E. A. M. (1994) Slow metabolic deterioration towards diabetes in islet cell antibody positive patients with autoimmune polyendocrine disease. Diabetologia, 37 (4). pp. 365-371. ISSN 0012-186X

Diabetes Mellitus, Type 1

Bearzatto, Massimo and Naserke, Heike and Piquer, Sandra and Koczwara, Kerstin and Lampasona, Vito and Williams, Alistair and Christie, Michael R. and Bingley, Polly J. and Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Bingley, P. J. and Christie, M. R. and Bonifacio, E. and Bonfanti, R. and Shattock, M. and Fonte, M.-T. and Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Bonifacio, E. and Christie, M. R. (1997) Islet cell antigens in the prediction and prevention of insulin-dependent diabetes mellitus. Annals of Medicine, 29 (5). pp. 405-412. ISSN 0785-3890

Christie, M. R. (1996) Islet cell autoantigens in type 1 diabetes. European Journal of Clinical Investigation, 26 (10). pp. 827-838. ISSN 0014-2972

Christie, Michael R. and Molvig, Jens and Hawkes, Charlotte J. and Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

Christie, Michael R. and Roll, Ursula and Payton, Mark A. and Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Damanhouri, L. H. and Dromey, J. A. and Christie, Michael R. and Nasrat, H. A. and Ardawi, M. S. M. and Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Desai, M.a and Cull, C.A.b and Horton, V.A.a and Christie, M.R.c and Bonifacio, E.d and Lampasona, V.d and Bingley, P.J.e and Levy, J.C.a and Mackay, I.R.f and Zimmet, P.g and Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Gillespie, Kathleen M. and Bain, Steven C. and Barnett, Anthony H. and Bingley, Polly J. and Christie, Michael R. and Gill, Geoffrey V. and Gale, Edwin A. M. (2004) The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. The Lancet, 364 (9446). pp. 1699-1700. ISSN 0140-6736

Gorus, F. K. and Goubert, P. and Semakula, C. and Vandewalle, C. L. and De Schepper, J. and Scheen, A. and Christie, Michael R. and Pipeleers, D. G. (1997) IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia, 40 (1). pp. 95-99. ISSN 0012-186X

Gylling, Mikhail and Tuomi, Tiinamaija and Bjorses, Petra and Kontiainen, Sirkka and Partanen, Jukka and Christie, Michael R. and Knip, Mikael and Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

Hatfield, E. C. I. and Hawkes, C. J. and Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Hawa, M. and Rowe, R. and Lan, M. S. and Notkins, A. L. and Pozzilli, P. and Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Hawkes, C. J. and Schloot, N. C. and Marks, J. and Willemen, S. J. M. and Drijfhout, J. W. and Mayer, E. K. and Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

Hawkes, C. J. and Wasmeier, C. and Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Morgenthaler, N. G. and Löbner, K. and Morgenthaler, U. Y. and Christie, M. R. and Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Morgenthaler, N. G. and Seissler, J. and Achenbach, P. and Glawe, D. and Payton, M. and Meinck, H.-M. and Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Piquer, Sandra and Valera, Lionel and Lampasona, Vito and Jardin-Watelet, Benedicte and Roche, Stephanie and Granier, Claude and Roquet, Francoise and Christie, Michael R. and Giordano, Tiziana and Malosio, Maria-Luisa and Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

Roll, U. and Christie, M. R. and Fuchtenbusch, M. and Payton, M. A. and Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Seissler, J. and Morgenthaler, N. G. and Achenbach, P. and Lampeter, E .F. and Glawe, D. and Payton, M. and Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

Tremble, Jennifer and Morgenthaler, Nils G. and Vlug, Arjen and Powers, Alvin C. and Christie, Michael R. and Scherbaum, Werner A. and Banga, J. Paul (1997) Human B cells secreting immunoglobulin G to glutamic acid decarboxylase- 65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes. Journal of Clinical Endocrinology and Metabolism, 82 (8). pp. 2664-2670. ISSN 0021-972X

Winnock, Frederic and Christie, Michael R. and Batstra, Manou R. and Aanstoot, Henk-Jan and Weets, Ilse and Decochez, Katelijn and Jopart, Philippe and Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

Diabetes Mellitus, Type 2

Damanhouri, L. H. and Dromey, J. A. and Christie, Michael R. and Nasrat, H. A. and Ardawi, M. S. M. and Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Diabetes, Gestational

Damanhouri, L. H. and Dromey, J. A. and Christie, Michael R. and Nasrat, H. A. and Ardawi, M. S. M. and Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Roll, U. and Christie, M. R. and Fuchtenbusch, M. and Payton, M. A. and Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Dietary antioxidants

Calabrese, V. and Bates, T. E. and Stella, A. M. (2000) NO synthase and NO-dependent signal pathways in brain aging and neurodegenerative disorders: the role of oxidant/antioxidant balance. Neurochemical Research, 25 (9-10). pp. 1315-41. ISSN 0364-3190

Disease Progression

Desai, M.a and Cull, C.A.b and Horton, V.A.a and Christie, M.R.c and Bonifacio, E.d and Lampasona, V.d and Bingley, P.J.e and Levy, J.C.a and Mackay, I.R.f and Zimmet, P.g and Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Disease Susceptibility

Lampeter, E. F. and Kolb, H. and Seifert, I. and Lohmann, D. and Heise, J. W. and Bertrams, J. and Christie, Michael and Kolb-Bachofen, V. (1994) Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity. Diabetologia, 37 (5). pp. 471-475. ISSN 0012-186X

Diseases in Twins

Bottazzo, G. F. and Genovese, S. and Bosi, E. and Dean, B. M. and Christie, M. R. and Bonifacio, E. (1991) Novel considerations on the antibody/autoantigen system in type I (insulin-dependent) diabetes mellitus. Annals of Medicine, 23 (4). pp. 453-461. ISSN 0785-3890

Christie, M. R. and Tun, R. Y. M. and Lo, S. S. S. and Cassidy, D. and Brown, T. J. and Hollands, J. and Shattock, M. and Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Dithizone

Hansen, W.A. and Christie, M.R. and Kahn, R. and Norgaard, A. and Abel, I. and Petersen, A.M. and Jorgensen, D.W. and Baekkeskov, S. and Nielsen, J.H. and Lernmark, A. and Egeberg, J. and Richter-Olesen, H. and Grainger, T. and Kristensen, J.K. and Brynitz, S. and Bilde, T. (1989) Supravital dithizone staining in the isolation of human and rat pancreatic islets. Diabetes Research, 10 (2). pp. 53-57. ISSN 0265-5985

EM

Bates, T. E. and Loesch, A. and Burnstock, G. and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochemical and biophysical research communications, 218 (1). pp. 40-44. ISSN 0006-291X

ET

Rinaldi, Ciro and Martinelli, Vincenzo and Rinaldi, Paola and Ciancia, Rosanna and del Vecchio, Luigi (2008) GATA1 is overexpressed in patients with essential thrombocythemia and polycythemia vera but not in patients with primary myelofibrosis or chronic myelogenous leukemia. Leukemia & lymphoma, 49 (7). pp. 1416-1419. ISSN 1042-8194

EVI1

Laricchia-Robbio, Leopoldo and Fazzina, Raffaella and Li, Donglan and Rinaldi, Ciro and Sinha, Kisaly K. and Chakraborty, Soumen and Nucifora, Giuseppina (2006) Point mutations in two EVI1 Zn fingers abolish EVI1-GATA1 interaction and allow erythroid differentiation of murine bone marrow cells. Molecular and cellular biology, 26 (20). pp. 7658-7666. ISSN 0270-7306

Laricchia-Robbio, Leopoldo and Premanand, Kavitha and Rinaldi, Ciro R. and Nucifora, Giuseppina (2009) EVI1 Impairs myelopoiesis by deregulation of PU.1 function. Cancer Research, 69 (4). pp. 1633-1642. ISSN 0008-5472

Senyuk, Vitalyi and Sinha, Kislay K. and Li, Donglan and Rinaldi, Ciro R. and Yanamandra, Sastry and Nucifora, Giuseppina (2007) Repression of RUNX1 activity by EVI1: a new role of EVI1 in leukemogenesis. Cancer research, 67 (12). pp. 5658-5666. ISSN 1538-7445

Electron Microscopy

Bates, T. E. and Loesch, A. and Burnstock, G. and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochemical and biophysical research communications, 218 (1). pp. 40-44. ISSN 0006-291X

Electron Transport Chain

Allen, Kathryn L. and Almeida, Angeles and Bates, Timothy E. and Clark, John B. (1995) Changes of respiratory chain activity in mitochondrial and synaptosomal fractions isolated from the gerbil brain after graded ischaemia. Journal of neurochemistry, 64 (5). pp. 2222-2229. ISSN 0022-3042

Almeida, A. and Brooks, K. J. and Sammut, I. and Keelan, J. and Davey, G. P. and Clark, J. B. and Bates, T. E. (1995) Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain. Developmental neuroscience, 17 (4). pp. 212-218. ISSN 0378-5866

Almeida, A. and Brooks, K. J. and Sammut, I. and Keelan, J. and Davey, G. P. and Clark, J. B. and Bates, T. E. (1995) Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain. Developmental Neuroscience, 17 (4). pp. 212-218. ISSN 0378-5866

Almeida, Angeles and Allen, Kathryn L. and Bates, TImothy E. and Clark, John B. (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. Journal of neurochemistry, 65 (4). pp. 1698-1703. ISSN 0022-3042

Electrophoresis, Gel, Two-Dimensional

Baekkeskov, S. and Warnock, G. and Christie, M. and Rajotte, R.V. and Larsen, P.M. and Fey, S. (1989) Revelation of specificity of 64K autoantibodies in IDDM serums by high-resolution 2-D gel electrophoresis. Unambiguous identification of 64K target antigen. Diabetes, 38 (9). pp. 1133-1141. ISSN 0012-1797

Christie, M. R. and Hollands, J. A. and Brown, T. J. and Michelsen, B. K. and Delovitch, T. L. (1993) Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. Journal of Clinical Investigation, 92 (1). pp. 240-248. ISSN 0021-9738

Electrophoresis, Polyacrylamide Gel

Baekkeskov, S. and Warnock, G. and Christie, M. and Rajotte, R.V. and Larsen, P.M. and Fey, S. (1989) Revelation of specificity of 64K autoantibodies in IDDM serums by high-resolution 2-D gel electrophoresis. Unambiguous identification of 64K target antigen. Diabetes, 38 (9). pp. 1133-1141. ISSN 0012-1797

Endothelial function

Klonizakis, Markos and Manning, Gillian and Donnelly, Richard (2011) Assessment of lower limb microcirculation: exploring the reproducibility and clinical application of laser doppler techniques. Skin Pharmacology and Physiology: Journal of Pharmacological and Biophysical Research, 24 (3). pp. 136-143. ISSN 1660-5527

Epitopes

Christie, M. R. (1996) Islet cell autoantigens in type 1 diabetes. European Journal of Clinical Investigation, 26 (10). pp. 827-838. ISSN 0014-2972

Desai, M.a and Cull, C.A.b and Horton, V.A.a and Christie, M.R.c and Bonifacio, E.d and Lampasona, V.d and Bingley, P.J.e and Levy, J.C.a and Mackay, I.R.f and Zimmet, P.g and Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Hatfield, E. C. I. and Hawkes, C. J. and Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Hawkes, C. J. and Schloot, N. C. and Marks, J. and Willemen, S. J. M. and Drijfhout, J. W. and Mayer, E. K. and Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

Morgenthaler, N. G. and Löbner, K. and Morgenthaler, U. Y. and Christie, M. R. and Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Piquer, Sandra and Valera, Lionel and Lampasona, Vito and Jardin-Watelet, Benedicte and Roche, Stephanie and Granier, Claude and Roquet, Francoise and Christie, Michael R. and Giordano, Tiziana and Malosio, Maria-Luisa and Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

Tremble, Jennifer and Morgenthaler, Nils G. and Vlug, Arjen and Powers, Alvin C. and Christie, Michael R. and Scherbaum, Werner A. and Banga, J. Paul (1997) Human B cells secreting immunoglobulin G to glutamic acid decarboxylase- 65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes. Journal of Clinical Endocrinology and Metabolism, 82 (8). pp. 2664-2670. ISSN 0021-972X

Exercise

Tew, G. and Klonizakis, Markos and Saxton, G. (2010) Effects of ageing and fitness on skin-microvessel vasodilator function in humans. European Journal of Applied Physiology, 109 (2). pp. 173-181. ISSN 1439-6319

Family

Payton, M. A. and Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Fathers

Roll, U. and Christie, M. R. and Fuchtenbusch, M. and Payton, M. A. and Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Fatty acide ethyl esters

Calabrese, V. and Scapagnini, G. and Catalano, C. and Dinotta, F. and Bates, T. E. and Calvani, M. and Stella, A. M. (2001) Effects of acetyl-L-carnitine on the formation of fatty acid ethyl esters in brain and peripheral organs after short-term ethanol administration in rat. Neurochemical Research, 26 (2). pp. 167-74. ISSN 0364-3190

Female

Gorus, F. K. and Goubert, P. and Semakula, C. and Vandewalle, C. L. and De Schepper, J. and Scheen, A. and Christie, Michael R. and Pipeleers, D. G. (1997) IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia, 40 (1). pp. 95-99. ISSN 0012-186X

Hawkes, C. J. and Schloot, N. C. and Marks, J. and Willemen, S. J. M. and Drijfhout, J. W. and Mayer, E. K. and Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

Huang, Guo Cai and Zhao, Min and Jones, Peter and Persaud, Shanta and Ramracheya, Reshma and Lobner, Kristian and Christie, Michael R. and Banga, J. Paul and Peakman, Mark and Sirinivsan, Parthi and Rela, Mohammed and Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Zhao, M. and Amiel, S. A. and Christie, Michael R. and Rela, M. and Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Fluorescent Antibody Technique

Wagner, R. and Genovese, S. and Bosi, E. and Becker, F. and Bingley, P. J. and Bonifacio, E. and Miles, K. A. and Christie, Michael and Bottazzo, G. F. and Gale, E. A. M. (1994) Slow metabolic deterioration towards diabetes in islet cell antibody positive patients with autoimmune polyendocrine disease. Diabetologia, 37 (4). pp. 365-371. ISSN 0012-186X

Fluorescent Antibody Technique, Indirect

Seissler, J. and Morgenthaler, N. G. and Achenbach, P. and Lampeter, E .F. and Glawe, D. and Payton, M. and Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

Tremble, Jennifer and Morgenthaler, Nils G. and Vlug, Arjen and Powers, Alvin C. and Christie, Michael R. and Scherbaum, Werner A. and Banga, J. Paul (1997) Human B cells secreting immunoglobulin G to glutamic acid decarboxylase- 65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes. Journal of Clinical Endocrinology and Metabolism, 82 (8). pp. 2664-2670. ISSN 0021-972X

Follow-Up Studies

Bingley, P. J. and Christie, M. R. and Bonifacio, E. and Bonfanti, R. and Shattock, M. and Fonte, M.-T. and Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Christie, M. R. and Tun, R. Y. M. and Lo, S. S. S. and Cassidy, D. and Brown, T. J. and Hollands, J. and Shattock, M. and Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Christie, Michael R. and Molvig, Jens and Hawkes, Charlotte J. and Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

Christie, Michael R. and Roll, Ursula and Payton, Mark A. and Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Desai, M.a and Cull, C.A.b and Horton, V.A.a and Christie, M.R.c and Bonifacio, E.d and Lampasona, V.d and Bingley, P.J.e and Levy, J.C.a and Mackay, I.R.f and Zimmet, P.g and Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Hawa, M. and Rowe, R. and Lan, M. S. and Notkins, A. L. and Pozzilli, P. and Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Roll, U. and Christie, M. R. and Fuchtenbusch, M. and Payton, M. A. and Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Roll, U. and Christie, M. R. and Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

Seissler, J. and Morgenthaler, N. G. and Achenbach, P. and Lampeter, E .F. and Glawe, D. and Payton, M. and Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

Forecasting

Bonifacio, E. and Christie, M. R. (1997) Islet cell antigens in the prediction and prevention of insulin-dependent diabetes mellitus. Annals of Medicine, 29 (5). pp. 405-412. ISSN 0785-3890

GATA1

Rinaldi, Ciro and Martinelli, Vincenzo and Rinaldi, Paola and Ciancia, Rosanna and del Vecchio, Luigi (2008) GATA1 is overexpressed in patients with essential thrombocythemia and polycythemia vera but not in patients with primary myelofibrosis or chronic myelogenous leukemia. Leukemia & lymphoma, 49 (7). pp. 1416-1419. ISSN 1042-8194

GSH

Brooks, Keith J and Hargreaves, Iain and Bhakoo, Kishore and Sellwood, Mark and O'Brien, Francis and Noone, Martina and Sakata, Yasuko and Cady, Ernest and Wylezinska, Marzena and Thornton, John and Ordidge, Roger and Nguyen, Quyen and Clemence, Matthew and Wyatt, John and Bates, Timothy E. (2002) Delayed hypothermia prevents decreases in N-acetylaspartate and reduced glutathione in the cerebral cortex of the neonatal pig following transient hypoxia-ischaemia. Neurochemical Research, 27 (12). pp. 1599-604. ISSN 0364-3190

Calabrese, Vittorio and Testa, Guiseppe and Ravagna, Agrippino and Bates, Timothy Edward and Stella, Anna Maria (2000) HSP70 induction in the brain following ethanol administration in the rat: regulation by glutathione redox state. Biochemical and Biophysical Research Communications, 269 (2). pp. 397-400. ISSN 0006-291X

Heales, S. J. and Davies, S. E. and Bates, T. E. and Clark, J. B. (1995) Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration. Neurochemical research, 20 (1). pp. 31-38. ISSN 0364-3190

Kenyon, Susan H. and Waterfield, Catherine J. and Asker, Daniel S. and Kudo, Mariko and Moss, David W. and Bates, Timothy E. and Nicolaou, Anna and Gibbons, William A. and Timbrell, John A. (1999) Effect of hydrazine upon vitamin B12-dependent methionine synthase activity and the sulphur amino acid pathway in isolated rat hepatocytes. Biochemical Pharmacology, 57 (11). pp. 1311-1319. ISSN 0006-2952

Gene Expression Regulation, Bacterial

Morgenthaler, N. G. and Löbner, K. and Morgenthaler, U. Y. and Christie, M. R. and Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Genes, MHC Class II

Gylling, Mikhail and Tuomi, Tiinamaija and Bjorses, Petra and Kontiainen, Sirkka and Partanen, Jukka and Christie, Michael R. and Knip, Mikael and Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

Genetic Predisposition to Disease

Gillespie, Kathleen M. and Bain, Steven C. and Barnett, Anthony H. and Bingley, Polly J. and Christie, Michael R. and Gill, Geoffrey V. and Gale, Edwin A. M. (2004) The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. The Lancet, 364 (9446). pp. 1699-1700. ISSN 0140-6736

Gerbil

Canevari, Laura and Console, Antonella and Tendi, E. A. and Clark, J. B. and Bates, Timothy (1999) Effect of postischaemic hypothermia on the mitochondrial damage induced by ischaemia and reperfusion in the gerbil. Brain research, 817 (1-2). pp. 241-245. ISSN 0006-8993

Glucagon

Wagner, R. and McNally, J. M. and Bonifacio, E. and Genovese, S. and Foulis, A. and McGill, M. and Christie, M. R. and Betterle, C. and Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

Glucose

Zhao, M. and Christie, M.R. and Heaton, N. and George, S. and Amiel, S. and Huang, G.C. (2002) Amelioration of streptozotocin-induced diabetes in mice using human islet cells derived from long-term culture in vitro. Transplantation, 73 (9). pp. 1454-1460. ISSN 0041-1337

Glucose Tolerance Test

Christie, M. R. and Tun, R. Y. M. and Lo, S. S. S. and Cassidy, D. and Brown, T. J. and Hollands, J. and Shattock, M. and Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Roll, U. and Christie, M. R. and Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

Zhao, M. and Amiel, S. A. and Christie, Michael R. and Rela, M. and Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Glutamate Decarboxylase

Christie, Michael and Brown, T. J. and Cassidy, D. (1992) Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme. Diabetologia, 35 (4). pp. 380-384. ISSN 0012-186X

Damanhouri, L. H. and Dromey, J. A. and Christie, Michael R. and Nasrat, H. A. and Ardawi, M. S. M. and Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Desai, M.a and Cull, C.A.b and Horton, V.A.a and Christie, M.R.c and Bonifacio, E.d and Lampasona, V.d and Bingley, P.J.e and Levy, J.C.a and Mackay, I.R.f and Zimmet, P.g and Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Gorus, F. K. and Goubert, P. and Semakula, C. and Vandewalle, C. L. and De Schepper, J. and Scheen, A. and Christie, Michael R. and Pipeleers, D. G. (1997) IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia, 40 (1). pp. 95-99. ISSN 0012-186X

Payton, M. A. and Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Roll, U. and Christie, M. R. and Fuchtenbusch, M. and Payton, M. A. and Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Wagner, R. and Genovese, S. and Bosi, E. and Becker, F. and Bingley, P. J. and Bonifacio, E. and Miles, K. A. and Christie, Michael and Bottazzo, G. F. and Gale, E. A. M. (1994) Slow metabolic deterioration towards diabetes in islet cell antibody positive patients with autoimmune polyendocrine disease. Diabetologia, 37 (4). pp. 365-371. ISSN 0012-186X

Glutamate receptors

Rosin, Claudia and Bates, Timothy E. and Skaper, Stephen D. (2004) Excitatory amino acid induced oligodendrocyte cell death in vitro: receptor-dependent and -independent mechanisms. Journal of Neurochemistry, 90 (5). pp. 1173-1185. ISSN 0022-3042

Glutathione

Calabrese, Vittorio and Scapagnini, Giovanni and Ravagna, Agrippino and Bella, Rita and Foresti, Roberta and Bates, Timothy E. and Giuffrida Stella, Anna-Maria and Pennisi, Giovanni (2002) Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels. Journal of Neuroscience Research, 70 (4). pp. 580-7. ISSN 0360-4012

Heales, S. J. and Davies, S. E. and Bates, T. E. and Clark, J. B. (1995) Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration. Neurochemical research, 20 (1). pp. 31-38. ISSN 0364-3190

Huang, Guo Cai and Zhao, Min and Jones, Peter and Persaud, Shanta and Ramracheya, Reshma and Lobner, Kristian and Christie, Michael R. and Banga, J. Paul and Peakman, Mark and Sirinivsan, Parthi and Rela, Mohammed and Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

H202

Bates, T. E. and Heales, S. J. and Davies, S. E. and Boakye, P. and Clark, J. B. (1994) Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. Journal of neurochemistry, 63 (2). pp. 640-648. ISSN 0022-3042

H460

Athanasiou, Andriani and Clarke, Anna B. and Turner, Amy E. and Kumaran, Nethia M. and Vakilpour, Sara and Smith, Paul A. and Bagiokou, Dimitra and Bradshaw, Tracey D. and Westwell, Andrew D. and Fang, Lin and Lobo, Dileep N. and Constantinescu, Cris S. and Calabrese, Vittorio and Loesch, Andrzej and Alexander, Stephen P. H. and Clothier, Richard H. and Kendall, David A. and Bates, Timothy E. (2007) Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications, 364 (1). pp. 131-137. ISSN 0006-291x

Athanasiou, Andriani and Smith, Paul A. and Vakilpour, Sara and Kumaran, Nethia M. and Turner, Amy E. and Bagiokou, Dimitra and Layfield, Robert and Ray, David E. and Westwell, Andrew D. and Alexander, Stephen P. H. and Kendall, David A. and Lobo, Dileep N. and Watson, Susan A. and Lophatanon, Artitaya and Muir, Kenneth A. and Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

HLA Antigens

Hawkes, C. J. and Schloot, N. C. and Marks, J. and Willemen, S. J. M. and Drijfhout, J. W. and Mayer, E. K. and Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

HLA DQ antigen

Winnock, Frederic and Christie, Michael R. and Batstra, Manou R. and Aanstoot, Henk-Jan and Weets, Ilse and Decochez, Katelijn and Jopart, Philippe and Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

HLA DR1 antigen

Bearzatto, Massimo and Naserke, Heike and Piquer, Sandra and Koczwara, Kerstin and Lampasona, Vito and Williams, Alistair and Christie, Michael R. and Bingley, Polly J. and Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

HLA DR13 antigen

Bearzatto, Massimo and Naserke, Heike and Piquer, Sandra and Koczwara, Kerstin and Lampasona, Vito and Williams, Alistair and Christie, Michael R. and Bingley, Polly J. and Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

HLA DR3 antigen

Bearzatto, Massimo and Naserke, Heike and Piquer, Sandra and Koczwara, Kerstin and Lampasona, Vito and Williams, Alistair and Christie, Michael R. and Bingley, Polly J. and Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Lampeter, E. F. and Kolb, H. and Seifert, I. and Lohmann, D. and Heise, J. W. and Bertrams, J. and Christie, Michael and Kolb-Bachofen, V. (1994) Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity. Diabetologia, 37 (5). pp. 471-475. ISSN 0012-186X

HLA DR4 antigen

Bearzatto, Massimo and Naserke, Heike and Piquer, Sandra and Koczwara, Kerstin and Lampasona, Vito and Williams, Alistair and Christie, Michael R. and Bingley, Polly J. and Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

HLA DR4 antigen, adult

Lampeter, E. F. and Kolb, H. and Seifert, I. and Lohmann, D. and Heise, J. W. and Bertrams, J. and Christie, Michael and Kolb-Bachofen, V. (1994) Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity. Diabetologia, 37 (5). pp. 471-475. ISSN 0012-186X

HLA antigen

Bearzatto, Massimo and Naserke, Heike and Piquer, Sandra and Koczwara, Kerstin and Lampasona, Vito and Williams, Alistair and Christie, Michael R. and Bingley, Polly J. and Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

HLA antigen class 1

Wagner, R. and McNally, J. M. and Bonifacio, E. and Genovese, S. and Foulis, A. and McGill, M. and Christie, M. R. and Betterle, C. and Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

HLA antigen class 2

Gylling, Mikhail and Tuomi, Tiinamaija and Bjorses, Petra and Kontiainen, Sirkka and Partanen, Jukka and Christie, Michael R. and Knip, Mikael and Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

Wagner, R. and McNally, J. M. and Bonifacio, E. and Genovese, S. and Foulis, A. and McGill, M. and Christie, M. R. and Betterle, C. and Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

HLA antigen class 2, adolescent

Gillespie, Kathleen M. and Bain, Steven C. and Barnett, Anthony H. and Bingley, Polly J. and Christie, Michael R. and Gill, Geoffrey V. and Gale, Edwin A. M. (2004) The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. The Lancet, 364 (9446). pp. 1699-1700. ISSN 0140-6736

HLA system

Wagner, R. and McNally, J. M. and Bonifacio, E. and Genovese, S. and Foulis, A. and McGill, M. and Christie, M. R. and Betterle, C. and Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

HLA-D Antigens

Gorus, F. K. and Goubert, P. and Semakula, C. and Vandewalle, C. L. and De Schepper, J. and Scheen, A. and Christie, Michael R. and Pipeleers, D. G. (1997) IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia, 40 (1). pp. 95-99. ISSN 0012-186X

Wagner, R. and McNally, J. M. and Bonifacio, E. and Genovese, S. and Foulis, A. and McGill, M. and Christie, M. R. and Betterle, C. and Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

HLA-DQ Antigens

Gillespie, Kathleen M. and Bain, Steven C. and Barnett, Anthony H. and Bingley, Polly J. and Christie, Michael R. and Gill, Geoffrey V. and Gale, Edwin A. M. (2004) The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. The Lancet, 364 (9446). pp. 1699-1700. ISSN 0140-6736

Winnock, Frederic and Christie, Michael R. and Batstra, Manou R. and Aanstoot, Henk-Jan and Weets, Ilse and Decochez, Katelijn and Jopart, Philippe and Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

HLA-DR Antigens

Bearzatto, Massimo and Naserke, Heike and Piquer, Sandra and Koczwara, Kerstin and Lampasona, Vito and Williams, Alistair and Christie, Michael R. and Bingley, Polly J. and Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Gillespie, Kathleen M. and Bain, Steven C. and Barnett, Anthony H. and Bingley, Polly J. and Christie, Michael R. and Gill, Geoffrey V. and Gale, Edwin A. M. (2004) The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. The Lancet, 364 (9446). pp. 1699-1700. ISSN 0140-6736

HLA-DR3 Antigen

Lampeter, E. F. and Kolb, H. and Seifert, I. and Lohmann, D. and Heise, J. W. and Bertrams, J. and Christie, Michael and Kolb-Bachofen, V. (1994) Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity. Diabetologia, 37 (5). pp. 471-475. ISSN 0012-186X

HLA-DR4 Antigen

Lampeter, E. F. and Kolb, H. and Seifert, I. and Lohmann, D. and Heise, J. W. and Bertrams, J. and Christie, Michael and Kolb-Bachofen, V. (1994) Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity. Diabetologia, 37 (5). pp. 471-475. ISSN 0012-186X

HSP 70

Calabrese, Vittorio and Testa, Guiseppe and Ravagna, Agrippino and Bates, Timothy Edward and Stella, Anna Maria (2000) HSP70 induction in the brain following ethanol administration in the rat: regulation by glutathione redox state. Biochemical and Biophysical Research Communications, 269 (2). pp. 397-400. ISSN 0006-291X

HSP's

Calabrese, V. and Scapagnini, G. and Catalano, C. and Bates, T. E. and Geraci, D. and Pennisi, G. and Giuffrida Stella, A. M. (2001) Regulation of heat shock protein synthesis in human skin fibroblasts in response to oxidative stress: role of vitamin E. International Journal of Tissue Reactions, 23 (4). pp. 127-35. ISSN 0250-0868

HU 210

Athanasiou, Andriani and Clarke, Anna B. and Turner, Amy E. and Kumaran, Nethia M. and Vakilpour, Sara and Smith, Paul A. and Bagiokou, Dimitra and Bradshaw, Tracey D. and Westwell, Andrew D. and Fang, Lin and Lobo, Dileep N. and Constantinescu, Cris S. and Calabrese, Vittorio and Loesch, Andrzej and Alexander, Stephen P. H. and Clothier, Richard H. and Kendall, David A. and Bates, Timothy E. (2007) Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications, 364 (1). pp. 131-137. ISSN 0006-291x

Haplotypes

Gillespie, Kathleen M. and Bain, Steven C. and Barnett, Anthony H. and Bingley, Polly J. and Christie, Michael R. and Gill, Geoffrey V. and Gale, Edwin A. M. (2004) The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. The Lancet, 364 (9446). pp. 1699-1700. ISSN 0140-6736

Gylling, Mikhail and Tuomi, Tiinamaija and Bjorses, Petra and Kontiainen, Sirkka and Partanen, Jukka and Christie, Michael R. and Knip, Mikael and Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

Lampeter, E. F. and Kolb, H. and Seifert, I. and Lohmann, D. and Heise, J. W. and Bertrams, J. and Christie, Michael and Kolb-Bachofen, V. (1994) Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity. Diabetologia, 37 (5). pp. 471-475. ISSN 0012-186X

Heart

Bates, T. E. and Loesch, A. and Burnstock, G. and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochemical and biophysical research communications, 218 (1). pp. 40-44. ISSN 0006-291X

Sammut, Ivan A. and Jayakumar, Jay and Latif, Najmi and Rothery, Stephen and Severs, Nicholas J. and Smolenski, Ryszard T. and Bates, Timothy E. and Yacoub, Magdi H. (2001) Heat stress contributes to the enhancement of cardiac mitochondrial complex activity. The American Journal of Pathology, 158 (5). pp. 1821-31. ISSN 0002-9440

Heat

Tew, G. and Klonizakis, Markos and Moss, J. and Ruddock, A. D. and Saxton, J. M. and Hodges, G. J. (2011) Reproducibility of cutaneous thermal hyperaemia assessed by laser Doppler flowmetry in young and older adults. Microvascular Research, 81 (2). pp. 177-182. ISSN 0026-2862

Heat Shock

Calabrese, V. and Scapagnini, G. and Catalano, C. and Bates, T. E. and Dinotta, F. and Micali, G. and Giuffrida Stella, A. M. (2001) Induction of heat shock protein synthesis in human skin fibroblasts in response to oxidative stress: regulation by a natural antioxidant from rosemary extract. International Journal of Tissue Reactions, 23 (2). pp. 51-8. ISSN 0250-0868

Calabrese, V. and Scapagnini, G. and Catalano, C. and Bates, T. E. and Geraci, D. and Pennisi, G. and Giuffrida Stella, A. M. (2001) Regulation of heat shock protein synthesis in human skin fibroblasts in response to oxidative stress: role of vitamin E. International Journal of Tissue Reactions, 23 (4). pp. 127-35. ISSN 0250-0868

Sammut, Ivan A. and Jayakumar, Jay and Latif, Najmi and Rothery, Stephen and Severs, Nicholas J. and Smolenski, Ryszard T. and Bates, Timothy E. and Yacoub, Magdi H. (2001) Heat stress contributes to the enhancement of cardiac mitochondrial complex activity. The American Journal of Pathology, 158 (5). pp. 1821-31. ISSN 0002-9440

Heat-Shock Proteins

Christie, M. R. and Hollands, J. A. and Brown, T. J. and Michelsen, B. K. and Delovitch, T. L. (1993) Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. Journal of Clinical Investigation, 92 (1). pp. 240-248. ISSN 0021-9738

Hemoglobin A, Glycosylated

Christie, Michael R. and Molvig, Jens and Hawkes, Charlotte J. and Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

Desai, M.a and Cull, C.A.b and Horton, V.A.a and Christie, M.R.c and Bonifacio, E.d and Lampasona, V.d and Bingley, P.J.e and Levy, J.C.a and Mackay, I.R.f and Zimmet, P.g and Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Hepatocytes

Kenyon, Susan H. and Waterfield, Catherine J. and Asker, Daniel S. and Kudo, Mariko and Moss, David W. and Bates, Timothy E. and Nicolaou, Anna and Gibbons, William A. and Timbrell, John A. (1999) Effect of hydrazine upon vitamin B12-dependent methionine synthase activity and the sulphur amino acid pathway in isolated rat hepatocytes. Biochemical Pharmacology, 57 (11). pp. 1311-1319. ISSN 0006-2952

Histocompatibility Antigens Class I

Wagner, R. and McNally, J. M. and Bonifacio, E. and Genovese, S. and Foulis, A. and McGill, M. and Christie, M. R. and Betterle, C. and Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

Histocompatibility Antigens Class II

Gillespie, Kathleen M. and Bain, Steven C. and Barnett, Anthony H. and Bingley, Polly J. and Christie, Michael R. and Gill, Geoffrey V. and Gale, Edwin A. M. (2004) The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. The Lancet, 364 (9446). pp. 1699-1700. ISSN 0140-6736

Homeodomain Proteins

Zhao, M. and Amiel, S. A. and Christie, Michael R. and Rela, M. and Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Humans

Bearzatto, Massimo and Naserke, Heike and Piquer, Sandra and Koczwara, Kerstin and Lampasona, Vito and Williams, Alistair and Christie, Michael R. and Bingley, Polly J. and Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Bingley, P. J. and Christie, M. R. and Bonifacio, E. and Bonfanti, R. and Shattock, M. and Fonte, M.-T. and Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Bonifacio, E. and Christie, M. R. (1997) Islet cell antigens in the prediction and prevention of insulin-dependent diabetes mellitus. Annals of Medicine, 29 (5). pp. 405-412. ISSN 0785-3890

Christie, M. R. (1996) Islet cell autoantigens in type 1 diabetes. European Journal of Clinical Investigation, 26 (10). pp. 827-838. ISSN 0014-2972

Christie, Michael R. and Molvig, Jens and Hawkes, Charlotte J. and Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

Christie, Michael R. and Roll, Ursula and Payton, Mark A. and Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Damanhouri, L. H. and Dromey, J. A. and Christie, Michael R. and Nasrat, H. A. and Ardawi, M. S. M. and Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Desai, M.a and Cull, C.A.b and Horton, V.A.a and Christie, M.R.c and Bonifacio, E.d and Lampasona, V.d and Bingley, P.J.e and Levy, J.C.a and Mackay, I.R.f and Zimmet, P.g and Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Gillespie, Kathleen M. and Bain, Steven C. and Barnett, Anthony H. and Bingley, Polly J. and Christie, Michael R. and Gill, Geoffrey V. and Gale, Edwin A. M. (2004) The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. The Lancet, 364 (9446). pp. 1699-1700. ISSN 0140-6736

Gorus, F. K. and Goubert, P. and Semakula, C. and Vandewalle, C. L. and De Schepper, J. and Scheen, A. and Christie, Michael R. and Pipeleers, D. G. (1997) IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia, 40 (1). pp. 95-99. ISSN 0012-186X

Gylling, Mikhail and Tuomi, Tiinamaija and Bjorses, Petra and Kontiainen, Sirkka and Partanen, Jukka and Christie, Michael R. and Knip, Mikael and Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

Hatfield, E. C. I. and Hawkes, C. J. and Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Hawa, M. and Rowe, R. and Lan, M. S. and Notkins, A. L. and Pozzilli, P. and Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Hawkes, C. J. and Schloot, N. C. and Marks, J. and Willemen, S. J. M. and Drijfhout, J. W. and Mayer, E. K. and Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

Huang, Guo Cai and Zhao, Min and Jones, Peter and Persaud, Shanta and Ramracheya, Reshma and Lobner, Kristian and Christie, Michael R. and Banga, J. Paul and Peakman, Mark and Sirinivsan, Parthi and Rela, Mohammed and Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Lampeter, E. F. and Kolb, H. and Seifert, I. and Lohmann, D. and Heise, J. W. and Bertrams, J. and Christie, Michael and Kolb-Bachofen, V. (1994) Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity. Diabetologia, 37 (5). pp. 471-475. ISSN 0012-186X

Morgenthaler, N. G. and Löbner, K. and Morgenthaler, U. Y. and Christie, M. R. and Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Morgenthaler, N. G. and Seissler, J. and Achenbach, P. and Glawe, D. and Payton, M. and Meinck, H.-M. and Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Roll, U. and Christie, M. R. and Fuchtenbusch, M. and Payton, M. A. and Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Seissler, J. and Morgenthaler, N. G. and Achenbach, P. and Lampeter, E .F. and Glawe, D. and Payton, M. and Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

Tremble, Jennifer and Morgenthaler, Nils G. and Vlug, Arjen and Powers, Alvin C. and Christie, Michael R. and Scherbaum, Werner A. and Banga, J. Paul (1997) Human B cells secreting immunoglobulin G to glutamic acid decarboxylase- 65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes. Journal of Clinical Endocrinology and Metabolism, 82 (8). pp. 2664-2670. ISSN 0021-972X

Wagner, R. and McNally, J. M. and Bonifacio, E. and Genovese, S. and Foulis, A. and McGill, M. and Christie, M. R. and Betterle, C. and Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

Winnock, Frederic and Christie, Michael R. and Batstra, Manou R. and Aanstoot, Henk-Jan and Weets, Ilse and Decochez, Katelijn and Jopart, Philippe and Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

Zhao, M. and Amiel, S. A. and Christie, Michael R. and Rela, M. and Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Zhao, M. and Christie, M.R. and Heaton, N. and George, S. and Amiel, S. and Huang, G.C. (2002) Amelioration of streptozotocin-induced diabetes in mice using human islet cells derived from long-term culture in vitro. Transplantation, 73 (9). pp. 1454-1460. ISSN 0041-1337

Hydrogen peroxide

Bates, T. E. and Heales, S. J. and Davies, S. E. and Boakye, P. and Clark, J. B. (1994) Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. Journal of neurochemistry, 63 (2). pp. 640-648. ISSN 0022-3042

Hydrolysis

Bearzatto, Massimo and Naserke, Heike and Piquer, Sandra and Koczwara, Kerstin and Lampasona, Vito and Williams, Alistair and Christie, Michael R. and Bingley, Polly J. and Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Hypoglycemic Agents

Christie, Michael R. and Molvig, Jens and Hawkes, Charlotte J. and Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

Hypothermia

Canevari, Laura and Console, Antonella and Tendi, E. A. and Clark, J. B. and Bates, Timothy (1999) Effect of postischaemic hypothermia on the mitochondrial damage induced by ischaemia and reperfusion in the gerbil. Brain research, 817 (1-2). pp. 241-245. ISSN 0006-8993

IA 2 antigen

Piquer, Sandra and Valera, Lionel and Lampasona, Vito and Jardin-Watelet, Benedicte and Roche, Stephanie and Granier, Claude and Roquet, Francoise and Christie, Michael R. and Giordano, Tiziana and Malosio, Maria-Luisa and Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

IA 2beta antigen

Piquer, Sandra and Valera, Lionel and Lampasona, Vito and Jardin-Watelet, Benedicte and Roche, Stephanie and Granier, Claude and Roquet, Francoise and Christie, Michael R. and Giordano, Tiziana and Malosio, Maria-Luisa and Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

ICA512 autoantibody

Christie, Michael R. and Molvig, Jens and Hawkes, Charlotte J. and Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

Winnock, Frederic and Christie, Michael R. and Batstra, Manou R. and Aanstoot, Henk-Jan and Weets, Ilse and Decochez, Katelijn and Jopart, Philippe and Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

IPTP

Levicar, Natasa and Dewey, Ricardo A. and Daley, Emma and Bates, Timothy E. and Davies, Derek and Kos, Janko and Pilkington, Geoffrey J. and Lah, Tamara T. (2003) Selective suppression of cathepsin L by antisense cDNA impairs human brain tumor cell invasion in vitro and promotes apoptosis. Cancer Gene Therapy, 10 (2). pp. 141-51. ISSN 0929-1903

Ia 2 antigen

Bearzatto, Massimo and Naserke, Heike and Piquer, Sandra and Koczwara, Kerstin and Lampasona, Vito and Williams, Alistair and Christie, Michael R. and Bingley, Polly J. and Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Ia antibody

Christie, Michael R. and Molvig, Jens and Hawkes, Charlotte J. and Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

Damanhouri, L. H. and Dromey, J. A. and Christie, Michael R. and Nasrat, H. A. and Ardawi, M. S. M. and Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Gylling, Mikhail and Tuomi, Tiinamaija and Bjorses, Petra and Kontiainen, Sirkka and Partanen, Jukka and Christie, Michael R. and Knip, Mikael and Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

Ia antigen

Bearzatto, Massimo and Naserke, Heike and Piquer, Sandra and Koczwara, Kerstin and Lampasona, Vito and Williams, Alistair and Christie, Michael R. and Bingley, Polly J. and Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Piquer, Sandra and Valera, Lionel and Lampasona, Vito and Jardin-Watelet, Benedicte and Roche, Stephanie and Granier, Claude and Roquet, Francoise and Christie, Michael R. and Giordano, Tiziana and Malosio, Maria-Luisa and Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

Immumnoelectron microscopy

Bates, T. E. and Loesch, A. and Burnstock, G. and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochemical and biophysical research communications, 218 (1). pp. 40-44. ISSN 0006-291X

Immunocytochemistry

Bates, T. E. and Loesch, A. and Burnstock, G. and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochemical and biophysical research communications, 218 (1). pp. 40-44. ISSN 0006-291X

Immunodominant Epitopes

Bearzatto, Massimo and Naserke, Heike and Piquer, Sandra and Koczwara, Kerstin and Lampasona, Vito and Williams, Alistair and Christie, Michael R. and Bingley, Polly J. and Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Hawkes, C. J. and Schloot, N. C. and Marks, J. and Willemen, S. J. M. and Drijfhout, J. W. and Mayer, E. K. and Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

Immunoglobulin G

Tremble, Jennifer and Morgenthaler, Nils G. and Vlug, Arjen and Powers, Alvin C. and Christie, Michael R. and Scherbaum, Werner A. and Banga, J. Paul (1997) Human B cells secreting immunoglobulin G to glutamic acid decarboxylase- 65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes. Journal of Clinical Endocrinology and Metabolism, 82 (8). pp. 2664-2670. ISSN 0021-972X

Immunohistochemistry

Piquer, Sandra and Valera, Lionel and Lampasona, Vito and Jardin-Watelet, Benedicte and Roche, Stephanie and Granier, Claude and Roquet, Francoise and Christie, Michael R. and Giordano, Tiziana and Malosio, Maria-Luisa and Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

Immunology

Christie, Michael (1999) Islet proteins implicated in pathogenesis of type 1 diabetes mellitus. Advances in Molecular and Cell Biology, 29 (C). pp. 75-100. ISSN 1569-2558

McLaughlin, Kerry A. and Richardson, Carolyn C. and Williams, Stefan and Bonifacio, Ezio and Morgan, Diana and Feltbower, Richard G. and Powell, Michael and Rees Smith, Bernard and Furmaniak, Jadwiga and Christie, Michael R. (2015) Relationships between major epitopes of the IA-2 autoantigen in Type 1 diabetes: implications for determinant spreading. Clinical Immunology, 160 (2). pp. 226-236. ISSN 1521-6616

Immunoprecipitation

Piquer, Sandra and Valera, Lionel and Lampasona, Vito and Jardin-Watelet, Benedicte and Roche, Stephanie and Granier, Claude and Roquet, Francoise and Christie, Michael R. and Giordano, Tiziana and Malosio, Maria-Luisa and Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

Immunosorbent Techniques

Christie, M. R. and Pipeleers, D. G. and Lernmark, A. and Baekkeskov, S. (1990) Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes. Journal of Biological Chemistry, 265 (1). pp. 376-381. ISSN 0021-9258

Tremble, Jennifer and Morgenthaler, Nils G. and Vlug, Arjen and Powers, Alvin C. and Christie, Michael R. and Scherbaum, Werner A. and Banga, J. Paul (1997) Human B cells secreting immunoglobulin G to glutamic acid decarboxylase- 65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes. Journal of Clinical Endocrinology and Metabolism, 82 (8). pp. 2664-2670. ISSN 0021-972X

Immunosuppressive Agents

Christie, Michael R. and Molvig, Jens and Hawkes, Charlotte J. and Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

Infant

Hawkes, C. J. and Schloot, N. C. and Marks, J. and Willemen, S. J. M. and Drijfhout, J. W. and Mayer, E. K. and Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

Morgenthaler, N. G. and Löbner, K. and Morgenthaler, U. Y. and Christie, M. R. and Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Morgenthaler, N. G. and Seissler, J. and Achenbach, P. and Glawe, D. and Payton, M. and Meinck, H.-M. and Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Infant, Newborn

Roll, U. and Christie, M. R. and Fuchtenbusch, M. and Payton, M. A. and Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Insulin

Hansen, W.A. and Christie, M.R. and Kahn, R. and Norgaard, A. and Abel, I. and Petersen, A.M. and Jorgensen, D.W. and Baekkeskov, S. and Nielsen, J.H. and Lernmark, A. and Egeberg, J. and Richter-Olesen, H. and Grainger, T. and Kristensen, J.K. and Brynitz, S. and Bilde, T. (1989) Supravital dithizone staining in the isolation of human and rat pancreatic islets. Diabetes Research, 10 (2). pp. 53-57. ISSN 0265-5985

Lampeter, E. F. and Kolb, H. and Seifert, I. and Lohmann, D. and Heise, J. W. and Bertrams, J. and Christie, Michael and Kolb-Bachofen, V. (1994) Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity. Diabetologia, 37 (5). pp. 471-475. ISSN 0012-186X

Wagner, R. and McNally, J. M. and Bonifacio, E. and Genovese, S. and Foulis, A. and McGill, M. and Christie, M. R. and Betterle, C. and Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

Insulin Antibodies

Baekkeskov, S. and Warnock, G. and Christie, M. and Rajotte, R.V. and Larsen, P.M. and Fey, S. (1989) Revelation of specificity of 64K autoantibodies in IDDM serums by high-resolution 2-D gel electrophoresis. Unambiguous identification of 64K target antigen. Diabetes, 38 (9). pp. 1133-1141. ISSN 0012-1797

Bottazzo, G. F. and Genovese, S. and Bosi, E. and Dean, B. M. and Christie, M. R. and Bonifacio, E. (1991) Novel considerations on the antibody/autoantigen system in type I (insulin-dependent) diabetes mellitus. Annals of Medicine, 23 (4). pp. 453-461. ISSN 0785-3890

Christie, Michael R. and Roll, Ursula and Payton, Mark A. and Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Lampeter, E. F. and Kolb, H. and Seifert, I. and Lohmann, D. and Heise, J. W. and Bertrams, J. and Christie, Michael and Kolb-Bachofen, V. (1994) Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity. Diabetologia, 37 (5). pp. 471-475. ISSN 0012-186X

Roll, U. and Christie, M. R. and Fuchtenbusch, M. and Payton, M. A. and Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Wagner, R. and Genovese, S. and Bosi, E. and Becker, F. and Bingley, P. J. and Bonifacio, E. and Miles, K. A. and Christie, Michael and Bottazzo, G. F. and Gale, E. A. M. (1994) Slow metabolic deterioration towards diabetes in islet cell antibody positive patients with autoimmune polyendocrine disease. Diabetologia, 37 (4). pp. 365-371. ISSN 0012-186X

Interferon gamma

Moss, David W. and Bates, Timothy E. (2001) Activation of murine microglial cell lines by lipopolysaccharide and interferon-gamma causes NO-mediated decreases in mitochondrial and cellular function. The European Journal of Neuroscience, 13 (3). pp. 529-38. ISSN 0953-816X

Iodine Radioisotopes

Morgenthaler, N. G. and Löbner, K. and Morgenthaler, U. Y. and Christie, M. R. and Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Iontophoresis

Klonizakis, Markos and Manning, Gillian and Donnelly, Richard (2011) Assessment of lower limb microcirculation: exploring the reproducibility and clinical application of laser doppler techniques. Skin Pharmacology and Physiology: Journal of Pharmacological and Biophysical Research, 24 (3). pp. 136-143. ISSN 1660-5527

Ischaemia

Allen, Kathryn L. and Almeida, Angeles and Bates, Timothy E. and Clark, John B. (1995) Changes of respiratory chain activity in mitochondrial and synaptosomal fractions isolated from the gerbil brain after graded ischaemia. Journal of neurochemistry, 64 (5). pp. 2222-2229. ISSN 0022-3042

Almeida, Angeles and Allen, Kathryn L. and Bates, TImothy E. and Clark, John B. (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. Journal of neurochemistry, 65 (4). pp. 1698-1703. ISSN 0022-3042

Brooks, Keith J. and Hargreaves, Iain P. and Bates, Timothy E. (2008) Protection of respiratory chain enzymes from ischaemic damage in adult rat brain slices. Neurochemical research, 33 (9). pp. 1711-1716. ISSN 0364-3190

Ischemia

Allen, Kathryn L. and Almeida, Angeles and Bates, Timothy E. and Clark, John B. (1995) Changes of respiratory chain activity in mitochondrial and synaptosomal fractions isolated from the gerbil brain after graded ischaemia. Journal of neurochemistry, 64 (5). pp. 2222-2229. ISSN 0022-3042

Almeida, Angeles and Allen, Kathryn L. and Bates, TImothy E. and Clark, John B. (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. Journal of neurochemistry, 65 (4). pp. 1698-1703. ISSN 0022-3042

Brooks, Keith J and Hargreaves, Iain and Bhakoo, Kishore and Sellwood, Mark and O'Brien, Francis and Noone, Martina and Sakata, Yasuko and Cady, Ernest and Wylezinska, Marzena and Thornton, John and Ordidge, Roger and Nguyen, Quyen and Clemence, Matthew and Wyatt, John and Bates, Timothy E. (2002) Delayed hypothermia prevents decreases in N-acetylaspartate and reduced glutathione in the cerebral cortex of the neonatal pig following transient hypoxia-ischaemia. Neurochemical Research, 27 (12). pp. 1599-604. ISSN 0364-3190

Brooks, Keith J. and Hargreaves, Iain P. and Bates, Timothy E. (2008) Protection of respiratory chain enzymes from ischaemic damage in adult rat brain slices. Neurochemical research, 33 (9). pp. 1711-1716. ISSN 0364-3190

Kuroda, Satoshi and Katsura, Ken-ichiro and Hillered, Lars and Bates, Timothy E. and Siesjö, Bo K. (1996) Delayed treatment with alpha-phenyl-N-tert-butyl nitrone (PBN) attenuates secondary mitochondrial dysfunction after transient focal cerebral ischemia in the rat. Neurobiology of Disease, 3 (2). pp. 149-157. ISSN 0969-9961

Islets of Langerhans

Baekkeskov, S. and Warnock, G. and Christie, M. and Rajotte, R.V. and Larsen, P.M. and Fey, S. (1989) Revelation of specificity of 64K autoantibodies in IDDM serums by high-resolution 2-D gel electrophoresis. Unambiguous identification of 64K target antigen. Diabetes, 38 (9). pp. 1133-1141. ISSN 0012-1797

Bearzatto, Massimo and Naserke, Heike and Piquer, Sandra and Koczwara, Kerstin and Lampasona, Vito and Williams, Alistair and Christie, Michael R. and Bingley, Polly J. and Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Bingley, P. J. and Christie, M. R. and Bonifacio, E. and Bonfanti, R. and Shattock, M. and Fonte, M.-T. and Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Bonifacio, E. and Christie, M. R. (1997) Islet cell antigens in the prediction and prevention of insulin-dependent diabetes mellitus. Annals of Medicine, 29 (5). pp. 405-412. ISSN 0785-3890

Bottazzo, G. F. and Genovese, S. and Bosi, E. and Dean, B. M. and Christie, M. R. and Bonifacio, E. (1991) Novel considerations on the antibody/autoantigen system in type I (insulin-dependent) diabetes mellitus. Annals of Medicine, 23 (4). pp. 453-461. ISSN 0785-3890

Christie, M. R. (1993) Characterization of distinct islet protein auto antigens associated with type 1 diabetes. Autoimmunity, 15 (s1). pp. 1-3. ISSN 0891-6934

Christie, M. R. (1996) Islet cell autoantigens in type 1 diabetes. European Journal of Clinical Investigation, 26 (10). pp. 827-838. ISSN 0014-2972

Christie, M. R. and Daneman, D. and Champagne, P. and Delovitch, T. L. (1990) Persistence of serum antibodies to 64,000-Mr islet cell protein after onset of type I diabetes. Diabetes, 39 (6). pp. 653-656. ISSN 0012-1797

Christie, M. R. and Genovese, S. and Cassidy, D. and Bosi, E. and Brown, T. J. and Lai, M. and Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

Christie, M. R. and Hollands, J. A. and Brown, T. J. and Michelsen, B. K. and Delovitch, T. L. (1993) Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. Journal of Clinical Investigation, 92 (1). pp. 240-248. ISSN 0021-9738

Christie, M. R. and Pipeleers, D. G. and Lernmark, A. and Baekkeskov, S. (1990) Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes. Journal of Biological Chemistry, 265 (1). pp. 376-381. ISSN 0021-9258

Christie, M. R. and Tun, R. Y. M. and Lo, S. S. S. and Cassidy, D. and Brown, T. J. and Hollands, J. and Shattock, M. and Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Christie, M. R. and Vohra, G. and Champagne, P. and Daneman, D. and Delovitch, T. L. (1990) Distinct antibody specificities to a 64-kD islet cell antigen in Type 1 diabetes as revealed by trypsin treatment. Journal of Experimental Medicine, 172 (3). pp. 789-794. ISSN 0022-1007

Christie, Michael and Brown, T. J. and Cassidy, D. (1992) Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme. Diabetologia, 35 (4). pp. 380-384. ISSN 0012-186X

Christie, Michael and Landin-Olsson, M. and Sundkvist, G. and Dahlquist, G. and Lernmark, A. and Baekkeskov, S. (1988) Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes. Diabetologia, 31 (8). pp. 597-602. ISSN 0012-186X

Christie, Michael R. and Roll, Ursula and Payton, Mark A. and Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Gorus, F. K. and Goubert, P. and Semakula, C. and Vandewalle, C. L. and De Schepper, J. and Scheen, A. and Christie, Michael R. and Pipeleers, D. G. (1997) IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia, 40 (1). pp. 95-99. ISSN 0012-186X

Gylling, Mikhail and Tuomi, Tiinamaija and Bjorses, Petra and Kontiainen, Sirkka and Partanen, Jukka and Christie, Michael R. and Knip, Mikael and Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

Hansen, W.A. and Christie, M.R. and Kahn, R. and Norgaard, A. and Abel, I. and Petersen, A.M. and Jorgensen, D.W. and Baekkeskov, S. and Nielsen, J.H. and Lernmark, A. and Egeberg, J. and Richter-Olesen, H. and Grainger, T. and Kristensen, J.K. and Brynitz, S. and Bilde, T. (1989) Supravital dithizone staining in the isolation of human and rat pancreatic islets. Diabetes Research, 10 (2). pp. 53-57. ISSN 0265-5985

Hawa, M. and Rowe, R. and Lan, M. S. and Notkins, A. L. and Pozzilli, P. and Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Hawkes, C. J. and Wasmeier, C. and Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Huang, Guo Cai and Zhao, Min and Jones, Peter and Persaud, Shanta and Ramracheya, Reshma and Lobner, Kristian and Christie, Michael R. and Banga, J. Paul and Peakman, Mark and Sirinivsan, Parthi and Rela, Mohammed and Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Lampeter, E. F. and Kolb, H. and Seifert, I. and Lohmann, D. and Heise, J. W. and Bertrams, J. and Christie, Michael and Kolb-Bachofen, V. (1994) Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity. Diabetologia, 37 (5). pp. 471-475. ISSN 0012-186X

Morgenthaler, N. G. and Seissler, J. and Achenbach, P. and Glawe, D. and Payton, M. and Meinck, H.-M. and Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Payton, M. A. and Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Roll, U. and Christie, M. R. and Fuchtenbusch, M. and Payton, M. A. and Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Roll, U. and Christie, M. R. and Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

Seissler, J. and Morgenthaler, N. G. and Achenbach, P. and Lampeter, E .F. and Glawe, D. and Payton, M. and Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

Tremble, Jennifer and Morgenthaler, Nils G. and Vlug, Arjen and Powers, Alvin C. and Christie, Michael R. and Scherbaum, Werner A. and Banga, J. Paul (1997) Human B cells secreting immunoglobulin G to glutamic acid decarboxylase- 65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes. Journal of Clinical Endocrinology and Metabolism, 82 (8). pp. 2664-2670. ISSN 0021-972X

Wagner, R. and Genovese, S. and Bosi, E. and Becker, F. and Bingley, P. J. and Bonifacio, E. and Miles, K. A. and Christie, Michael and Bottazzo, G. F. and Gale, E. A. M. (1994) Slow metabolic deterioration towards diabetes in islet cell antibody positive patients with autoimmune polyendocrine disease. Diabetologia, 37 (4). pp. 365-371. ISSN 0012-186X

Wagner, R. and McNally, J. M. and Bonifacio, E. and Genovese, S. and Foulis, A. and McGill, M. and Christie, M. R. and Betterle, C. and Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

Winnock, Frederic and Christie, Michael R. and Batstra, Manou R. and Aanstoot, Henk-Jan and Weets, Ilse and Decochez, Katelijn and Jopart, Philippe and Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

Zhao, M. and Christie, M.R. and Heaton, N. and George, S. and Amiel, S. and Huang, G.C. (2002) Amelioration of streptozotocin-induced diabetes in mice using human islet cells derived from long-term culture in vitro. Transplantation, 73 (9). pp. 1454-1460. ISSN 0041-1337

Islets of Langerhans Transplantation

Huang, Guo Cai and Zhao, Min and Jones, Peter and Persaud, Shanta and Ramracheya, Reshma and Lobner, Kristian and Christie, Michael R. and Banga, J. Paul and Peakman, Mark and Sirinivsan, Parthi and Rela, Mohammed and Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Zhao, M. and Christie, M.R. and Heaton, N. and George, S. and Amiel, S. and Huang, G.C. (2002) Amelioration of streptozotocin-induced diabetes in mice using human islet cells derived from long-term culture in vitro. Transplantation, 73 (9). pp. 1454-1460. ISSN 0041-1337

Isoenzymes

Christie, M. R. (1993) Characterization of distinct islet protein auto antigens associated with type 1 diabetes. Autoimmunity, 15 (s1). pp. 1-3. ISSN 0891-6934

Christie, Michael and Brown, T. J. and Cassidy, D. (1992) Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme. Diabetologia, 35 (4). pp. 380-384. ISSN 0012-186X

Damanhouri, L. H. and Dromey, J. A. and Christie, Michael R. and Nasrat, H. A. and Ardawi, M. S. M. and Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Gylling, Mikhail and Tuomi, Tiinamaija and Bjorses, Petra and Kontiainen, Sirkka and Partanen, Jukka and Christie, Michael R. and Knip, Mikael and Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

J774

Moss, David W. and Bates, Timothy E. (2001) Activation of murine microglial cell lines by lipopolysaccharide and interferon-gamma causes NO-mediated decreases in mitochondrial and cellular function. The European Journal of Neuroscience, 13 (3). pp. 529-38. ISSN 0953-816X

Kidney

Bates, T. E. and Loesch, A. and Burnstock, G. and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochemical and biophysical research communications, 218 (1). pp. 40-44. ISSN 0006-291X

L-buthionine sulfoximine

Heales, S. J. and Davies, S. E. and Bates, T. E. and Clark, J. B. (1995) Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration. Neurochemical research, 20 (1). pp. 31-38. ISSN 0364-3190

LASCA

Tew, Garry A. and Klonizakis, Markos and Crank, Helen and Briers, J. David and Hodges, Gary J. (2011) Comparison of laser speckle contrast imaging with laser Doppler for assessing microvascular function. Microvascular Research, 82 (3). pp. 326-332. ISSN 0026-2862

LDF

Tew, G. and Klonizakis, Markos and Moss, J. and Ruddock, A. D. and Saxton, J. M. and Hodges, G. J. (2011) Role of sensory nerves in the rapid cutaneous vasodilator response to local heating in young and older endurance-trained and untrained men. Experimental Physiology, 96 (2). pp. 163-170. ISSN 0958-0670

LPS

Moss, David W. and Bates, Timothy E. (2001) Activation of murine microglial cell lines by lipopolysaccharide and interferon-gamma causes NO-mediated decreases in mitochondrial and cellular function. The European Journal of Neuroscience, 13 (3). pp. 529-38. ISSN 0953-816X

Laser Doppler flowmetry

Tew, G. and Klonizakis, Markos and Moss, J. and Ruddock, A. D. and Saxton, J. M. and Hodges, G. J. (2011) Reproducibility of cutaneous thermal hyperaemia assessed by laser Doppler flowmetry in young and older adults. Microvascular Research, 81 (2). pp. 177-182. ISSN 0026-2862

Tew, G. and Klonizakis, Markos and Moss, J. and Ruddock, A. and Saxton, J. M. and Hodges, G. (2010) Role of sensory nerves in the rapid cutaneous vasodilator response to local heating in young and older endurance-trained and untrained men. In: 9th World Congress on Microcirculation, 26 - 28 September 2010, Maison de la Chimie, Paris.

Tew, G. and Klonizakis, Markos and Saxton, G. (2010) Effects of ageing and fitness on skin-microvessel vasodilator function in humans. European Journal of Applied Physiology, 109 (2). pp. 173-181. ISSN 1439-6319

Laser Doppler fluximetry

Klonizakis, Markos and Manning, Gillian and Donnelly, Richard (2011) Assessment of lower limb microcirculation: exploring the reproducibility and clinical application of laser doppler techniques. Skin Pharmacology and Physiology: Journal of Pharmacological and Biophysical Research, 24 (3). pp. 136-143. ISSN 1660-5527

Lectins

Payton, M. A. and Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Life Tables

Bingley, P. J. and Christie, M. R. and Bonifacio, E. and Bonfanti, R. and Shattock, M. and Fonte, M.-T. and Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Christie, Michael R. and Roll, Ursula and Payton, Mark A. and Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Lipopolysaccharide

Moss, David W. and Bates, Timothy E. (2001) Activation of murine microglial cell lines by lipopolysaccharide and interferon-gamma causes NO-mediated decreases in mitochondrial and cellular function. The European Journal of Neuroscience, 13 (3). pp. 529-38. ISSN 0953-816X

Liver

Bates, T. E and Loesch, A. and Burnstock, G. and Clark, J. B. (1995) Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver. Biochemical and biophysical research communications, 213 (3). pp. 896-900. ISSN 0006-291X

Dagnelie, P. C. and Bell, J. D. and Williams, S. C. and Bates, T. E. and Abel, P. D. and Foster, C. S. (1993) Altered phosphorylation status, phospholipid metabolism and gluconeogenesis in the host liver of rats with prostate cancer: a 31P magnetic resonance spectroscopy study. British Journal of Cancer, 67 (6). pp. 1303-1309. ISSN 0007-0920

Murphy, Elizabeth J. and Bates, Timothy E. and Williams, Stephen R. and Watson, Tracey and Brindle, Kevin M. and Rajagopalan, Bheeshma and Radda, George K. (1992) Endoplasmic reticulum: the major contributor to the PDE peak in hepatic 31P-NMR spectra at low magnetic field strengths. Biochimica et biophysica acta: biomembranes, 1111 (1). pp. 51-58. ISSN 0005-2736

Sammut, Ivan A. and Thorniley, Maureen S. and Simpkin, Sandra and Fuller, Barry J. and Bates, Timothy E. and Green, Colin J. (1998) Impairment of hepatic mitochondrial respiratory function following storage and orthotopic transplantation of rat livers. Cryobiology, 36 (1). pp. 49-60. ISSN 0011-2240

MCAO

Canevari, Laura and Kuroda, Satoshi and Bates, Timothy E. and Clark, John B. and Siesjö, Bo K. (1997) Activity of mitochondrial respiratory chain enzymes after transient focal ischemia in the rat. Journal of Cerebral Blood Flow and Metabolism : official Journal of the International Society of Cerebral Blood Flow and Metabolism, 17 (11). pp. 1166-9. ISSN 0271-678X

MPN

Rinaldi, Ciro R. and Rinaldi, Paola and Alagia, Adele and Gemei, Marica and Esposito, Nicola and Formiggini, Fabio and Martinelli, Vincenzo and Senyuk, Vitalyi and Nucifora, Giuseppina and Pane, Fabrizio (2010) Preferential nuclear accumulation of JAK2V617F in CD34+ but not in granulocytic, megakaryocytic, or erythroid cells of patients with Philadelphia-negative myeloproliferative neoplasia. Blood, 116 (26). pp. 6023-6026. ISSN 0006-4971

MPP+

Bates, T. E. and Heales, S. J. and Davies, S. E. and Boakye, P. and Clark, J. B. (1994) Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. Journal of neurochemistry, 63 (2). pp. 640-648. ISSN 0022-3042

MPT Pore

Kristián, Tibor and Gertsch, Jeff and Bates, Timothy E. and Siesjö, Bo K. (2000) Characteristics of the calcium-triggered mitochondrial permeability transition in nonsynaptic brain mitochondria: effect of cyclosporin A and ubiquinone O. Journal of Neurochemistry, 74 (5). pp. 1999-2009. ISSN 0022-3042

MPTP

Bates, T. E. and Heales, S. J. and Davies, S. E. and Boakye, P. and Clark, J. B. (1994) Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. Journal of neurochemistry, 63 (2). pp. 640-648. ISSN 0022-3042

MRS

Bates, Timothy E. and Strangward, Maria and Keelan, Julia and Davey, Gavin P. and Munro, Peter M. G. and Clark, John B. (1996) Inhibition of N-acetylaspartate production: implications for 1H MRS studies in vivo. Neuroreport, 7 (8). pp. 1397-1400. ISSN 0959-4965

Dagnelie, P. C. and Bell, J. D. and Williams, S. C. and Bates, T. E. and Abel, P. D. and Foster, C. S. (1993) Altered phosphorylation status, phospholipid metabolism and gluconeogenesis in the host liver of rats with prostate cancer: a 31P magnetic resonance spectroscopy study. British Journal of Cancer, 67 (6). pp. 1303-1309. ISSN 0007-0920

Dagnelie, Pieter C. and Bell, Jimmy D. and Williams, Steve C. and Bates, Timothy E. and Abel, Paul D. and Foster, Christopher S. (1994) Effect of fish oil on cancer cachexia and host liver metabolism in rats with prostate tumors. Lipids, 29 (3). pp. 195-203. ISSN 0024-4201

Male

Christie, M. R. and Pipeleers, D. G. and Lernmark, A. and Baekkeskov, S. (1990) Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes. Journal of Biological Chemistry, 265 (1). pp. 376-381. ISSN 0021-9258

Gorus, F. K. and Goubert, P. and Semakula, C. and Vandewalle, C. L. and De Schepper, J. and Scheen, A. and Christie, Michael R. and Pipeleers, D. G. (1997) IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia, 40 (1). pp. 95-99. ISSN 0012-186X

Hawkes, C. J. and Schloot, N. C. and Marks, J. and Willemen, S. J. M. and Drijfhout, J. W. and Mayer, E. K. and Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

Huang, Guo Cai and Zhao, Min and Jones, Peter and Persaud, Shanta and Ramracheya, Reshma and Lobner, Kristian and Christie, Michael R. and Banga, J. Paul and Peakman, Mark and Sirinivsan, Parthi and Rela, Mohammed and Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Tremble, Jennifer and Morgenthaler, Nils G. and Vlug, Arjen and Powers, Alvin C. and Christie, Michael R. and Scherbaum, Werner A. and Banga, J. Paul (1997) Human B cells secreting immunoglobulin G to glutamic acid decarboxylase- 65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes. Journal of Clinical Endocrinology and Metabolism, 82 (8). pp. 2664-2670. ISSN 0021-972X

Mass Screening

Christie, Michael R. and Roll, Ursula and Payton, Mark A. and Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Membrane Glycoproteins

Hatfield, E. C. I. and Hawkes, C. J. and Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Hawkes, C. J. and Schloot, N. C. and Marks, J. and Willemen, S. J. M. and Drijfhout, J. W. and Mayer, E. K. and Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

Hawkes, C. J. and Wasmeier, C. and Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Morgenthaler, N. G. and Löbner, K. and Morgenthaler, U. Y. and Christie, M. R. and Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Membrane Proteins

Bearzatto, Massimo and Naserke, Heike and Piquer, Sandra and Koczwara, Kerstin and Lampasona, Vito and Williams, Alistair and Christie, Michael R. and Bingley, Polly J. and Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Christie, Michael R. and Roll, Ursula and Payton, Mark A. and Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Hatfield, E. C. I. and Hawkes, C. J. and Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Hawa, M. and Rowe, R. and Lan, M. S. and Notkins, A. L. and Pozzilli, P. and Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Hawkes, C. J. and Schloot, N. C. and Marks, J. and Willemen, S. J. M. and Drijfhout, J. W. and Mayer, E. K. and Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

Hawkes, C. J. and Wasmeier, C. and Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Morgenthaler, N. G. and Löbner, K. and Morgenthaler, U. Y. and Christie, M. R. and Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Morgenthaler, N. G. and Seissler, J. and Achenbach, P. and Glawe, D. and Payton, M. and Meinck, H.-M. and Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Payton, M. A. and Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Piquer, Sandra and Valera, Lionel and Lampasona, Vito and Jardin-Watelet, Benedicte and Roche, Stephanie and Granier, Claude and Roquet, Francoise and Christie, Michael R. and Giordano, Tiziana and Malosio, Maria-Luisa and Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

Mice

Huang, Guo Cai and Zhao, Min and Jones, Peter and Persaud, Shanta and Ramracheya, Reshma and Lobner, Kristian and Christie, Michael R. and Banga, J. Paul and Peakman, Mark and Sirinivsan, Parthi and Rela, Mohammed and Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Piquer, Sandra and Valera, Lionel and Lampasona, Vito and Jardin-Watelet, Benedicte and Roche, Stephanie and Granier, Claude and Roquet, Francoise and Christie, Michael R. and Giordano, Tiziana and Malosio, Maria-Luisa and Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

Roll, U. and Christie, M. R. and Fuchtenbusch, M. and Payton, M. A. and Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Zhao, M. and Amiel, S. A. and Christie, Michael R. and Rela, M. and Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Zhao, M. and Christie, M.R. and Heaton, N. and George, S. and Amiel, S. and Huang, G.C. (2002) Amelioration of streptozotocin-induced diabetes in mice using human islet cells derived from long-term culture in vitro. Transplantation, 73 (9). pp. 1454-1460. ISSN 0041-1337

Mice, Inbred BALB C

Piquer, Sandra and Valera, Lionel and Lampasona, Vito and Jardin-Watelet, Benedicte and Roche, Stephanie and Granier, Claude and Roquet, Francoise and Christie, Michael R. and Giordano, Tiziana and Malosio, Maria-Luisa and Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

Mice, Inbred NOD

Roll, U. and Christie, M. R. and Fuchtenbusch, M. and Payton, M. A. and Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Mice, SCID

Huang, Guo Cai and Zhao, Min and Jones, Peter and Persaud, Shanta and Ramracheya, Reshma and Lobner, Kristian and Christie, Michael R. and Banga, J. Paul and Peakman, Mark and Sirinivsan, Parthi and Rela, Mohammed and Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Zhao, M. and Amiel, S. A. and Christie, Michael R. and Rela, M. and Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Zhao, M. and Christie, M.R. and Heaton, N. and George, S. and Amiel, S. and Huang, G.C. (2002) Amelioration of streptozotocin-induced diabetes in mice using human islet cells derived from long-term culture in vitro. Transplantation, 73 (9). pp. 1454-1460. ISSN 0041-1337

Microbial Collagenase

Hansen, W.A. and Christie, M.R. and Kahn, R. and Norgaard, A. and Abel, I. and Petersen, A.M. and Jorgensen, D.W. and Baekkeskov, S. and Nielsen, J.H. and Lernmark, A. and Egeberg, J. and Richter-Olesen, H. and Grainger, T. and Kristensen, J.K. and Brynitz, S. and Bilde, T. (1989) Supravital dithizone staining in the isolation of human and rat pancreatic islets. Diabetes Research, 10 (2). pp. 53-57. ISSN 0265-5985

Microvascular perfusion

Klonizakis, Markos and Manning, Gillian and Donnelly, Richard (2011) Assessment of lower limb microcirculation: exploring the reproducibility and clinical application of laser doppler techniques. Skin Pharmacology and Physiology: Journal of Pharmacological and Biophysical Research, 24 (3). pp. 136-143. ISSN 1660-5527

Middle Age

Christie, M. R. and Genovese, S. and Cassidy, D. and Bosi, E. and Brown, T. J. and Lai, M. and Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

Christie, Michael and Brown, T. J. and Cassidy, D. (1992) Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme. Diabetologia, 35 (4). pp. 380-384. ISSN 0012-186X

Roll, U. and Christie, M. R. and Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

Wagner, R. and Genovese, S. and Bosi, E. and Becker, F. and Bingley, P. J. and Bonifacio, E. and Miles, K. A. and Christie, Michael and Bottazzo, G. F. and Gale, E. A. M. (1994) Slow metabolic deterioration towards diabetes in islet cell antibody positive patients with autoimmune polyendocrine disease. Diabetologia, 37 (4). pp. 365-371. ISSN 0012-186X

Middle Aged

Bingley, P. J. and Christie, M. R. and Bonifacio, E. and Bonfanti, R. and Shattock, M. and Fonte, M.-T. and Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Damanhouri, L. H. and Dromey, J. A. and Christie, Michael R. and Nasrat, H. A. and Ardawi, M. S. M. and Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Desai, M.a and Cull, C.A.b and Horton, V.A.a and Christie, M.R.c and Bonifacio, E.d and Lampasona, V.d and Bingley, P.J.e and Levy, J.C.a and Mackay, I.R.f and Zimmet, P.g and Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Hawa, M. and Rowe, R. and Lan, M. S. and Notkins, A. L. and Pozzilli, P. and Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Huang, Guo Cai and Zhao, Min and Jones, Peter and Persaud, Shanta and Ramracheya, Reshma and Lobner, Kristian and Christie, Michael R. and Banga, J. Paul and Peakman, Mark and Sirinivsan, Parthi and Rela, Mohammed and Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Lampeter, E. F. and Kolb, H. and Seifert, I. and Lohmann, D. and Heise, J. W. and Bertrams, J. and Christie, Michael and Kolb-Bachofen, V. (1994) Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity. Diabetologia, 37 (5). pp. 471-475. ISSN 0012-186X

Morgenthaler, N. G. and Löbner, K. and Morgenthaler, U. Y. and Christie, M. R. and Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Morgenthaler, N. G. and Seissler, J. and Achenbach, P. and Glawe, D. and Payton, M. and Meinck, H.-M. and Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Wagner, R. and McNally, J. M. and Bonifacio, E. and Genovese, S. and Foulis, A. and McGill, M. and Christie, M. R. and Betterle, C. and Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

Zhao, M. and Amiel, S. A. and Christie, Michael R. and Rela, M. and Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Mitochondria

Allen, Kathryn L. and Almeida, Angeles and Bates, Timothy E. and Clark, John B. (1995) Changes of respiratory chain activity in mitochondrial and synaptosomal fractions isolated from the gerbil brain after graded ischaemia. Journal of neurochemistry, 64 (5). pp. 2222-2229. ISSN 0022-3042

Almeida, A. and Brooks, K. J. and Sammut, I. and Keelan, J. and Davey, G. P. and Clark, J. B. and Bates, T. E. (1995) Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain. Developmental neuroscience, 17 (4). pp. 212-218. ISSN 0378-5866

Almeida, Angeles and Allen, Kathryn L. and Bates, TImothy E. and Clark, John B. (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. Journal of neurochemistry, 65 (4). pp. 1698-1703. ISSN 0022-3042

Bates, T. E and Loesch, A. and Burnstock, G. and Clark, J. B. (1995) Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver. Biochemical and biophysical research communications, 213 (3). pp. 896-900. ISSN 0006-291X

Bates, T. E. and Heales, S. J. and Davies, S. E. and Boakye, P. and Clark, J. B. (1994) Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. Journal of neurochemistry, 63 (2). pp. 640-648. ISSN 0022-3042

Bates, Timothy E. and Strangward, Maria and Keelan, Julia and Davey, Gavin P. and Munro, Peter M. G. and Clark, John B. (1996) Inhibition of N-acetylaspartate production: implications for 1H MRS studies in vivo. Neuroreport, 7 (8). pp. 1397-1400. ISSN 0959-4965

Brooks, Keith J. and Hargreaves, Iain P. and Bates, Timothy E. (2008) Protection of respiratory chain enzymes from ischaemic damage in adult rat brain slices. Neurochemical research, 33 (9). pp. 1711-1716. ISSN 0364-3190

Canevari, Laura and Clark, John B. and Bates, Timothy E. (1999) Beta-amyloid fragment 25-35 selectively decreases complex IV activity in isolated mitochondria. FEBS Letters, 457 (1). pp. 131-4. ISSN 0014-5793

Heales, S. J. and Davies, S. E. and Bates, T. E. and Clark, J. B. (1995) Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration. Neurochemical research, 20 (1). pp. 31-38. ISSN 0364-3190

Sammut, Ivan A. and Thorniley, Maureen S. and Simpkin, Sandra and Fuller, Barry J. and Bates, Timothy E. and Green, Colin J. (1998) Impairment of hepatic mitochondrial respiratory function following storage and orthotopic transplantation of rat livers. Cryobiology, 36 (1). pp. 49-60. ISSN 0011-2240

Mitochondrial complexes

Canevari, Laura and Kuroda, Satoshi and Bates, Timothy E. and Clark, John B. and Siesjö, Bo K. (1997) Activity of mitochondrial respiratory chain enzymes after transient focal ischemia in the rat. Journal of Cerebral Blood Flow and Metabolism : official Journal of the International Society of Cerebral Blood Flow and Metabolism, 17 (11). pp. 1166-9. ISSN 0271-678X

Sammut, Ivan A. and Thorniley, Maureen S. and Simpkin, Sandra and Fuller, Barry J. and Bates, Timothy E. and Green, Colin J. (1998) Impairment of hepatic mitochondrial respiratory function following storage and orthotopic transplantation of rat livers. Cryobiology, 36 (1). pp. 49-60. ISSN 0011-2240

Molecular Sequence Data

Payton, M. A. and Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Piquer, Sandra and Valera, Lionel and Lampasona, Vito and Jardin-Watelet, Benedicte and Roche, Stephanie and Granier, Claude and Roquet, Francoise and Christie, Michael R. and Giordano, Tiziana and Malosio, Maria-Luisa and Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

Molecular Weight

Baekkeskov, S. and Warnock, G. and Christie, M. and Rajotte, R.V. and Larsen, P.M. and Fey, S. (1989) Revelation of specificity of 64K autoantibodies in IDDM serums by high-resolution 2-D gel electrophoresis. Unambiguous identification of 64K target antigen. Diabetes, 38 (9). pp. 1133-1141. ISSN 0012-1797

Christie, M. R. and Hollands, J. A. and Brown, T. J. and Michelsen, B. K. and Delovitch, T. L. (1993) Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. Journal of Clinical Investigation, 92 (1). pp. 240-248. ISSN 0021-9738

Christie, M. R. and Pipeleers, D. G. and Lernmark, A. and Baekkeskov, S. (1990) Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes. Journal of Biological Chemistry, 265 (1). pp. 376-381. ISSN 0021-9258

Christie, M. R. and Tun, R. Y. M. and Lo, S. S. S. and Cassidy, D. and Brown, T. J. and Hollands, J. and Shattock, M. and Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Christie, M. R. and Vohra, G. and Champagne, P. and Daneman, D. and Delovitch, T. L. (1990) Distinct antibody specificities to a 64-kD islet cell antigen in Type 1 diabetes as revealed by trypsin treatment. Journal of Experimental Medicine, 172 (3). pp. 789-794. ISSN 0022-1007

Hawkes, C. J. and Wasmeier, C. and Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Payton, M. A. and Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Mothers

Roll, U. and Christie, M. R. and Fuchtenbusch, M. and Payton, M. A. and Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Mutation

Hatfield, E. C. I. and Hawkes, C. J. and Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

N omega-nitro-L-arginine

Brooks, Keith J. and Hargreaves, Iain P. and Bates, Timothy E. (2008) Protection of respiratory chain enzymes from ischaemic damage in adult rat brain slices. Neurochemical research, 33 (9). pp. 1711-1716. ISSN 0364-3190

N-Acetylaspartate

Brooks, Keith J and Hargreaves, Iain and Bhakoo, Kishore and Sellwood, Mark and O'Brien, Francis and Noone, Martina and Sakata, Yasuko and Cady, Ernest and Wylezinska, Marzena and Thornton, John and Ordidge, Roger and Nguyen, Quyen and Clemence, Matthew and Wyatt, John and Bates, Timothy E. (2002) Delayed hypothermia prevents decreases in N-acetylaspartate and reduced glutathione in the cerebral cortex of the neonatal pig following transient hypoxia-ischaemia. Neurochemical Research, 27 (12). pp. 1599-604. ISSN 0364-3190

N-acetylaspartate

Bates, Timothy E. and Strangward, Maria and Keelan, Julia and Davey, Gavin P. and Munro, Peter M. G. and Clark, John B. (1996) Inhibition of N-acetylaspartate production: implications for 1H MRS studies in vivo. Neuroreport, 7 (8). pp. 1397-1400. ISSN 0959-4965

N11

Moss, David W. and Bates, Timothy E. (2001) Activation of murine microglial cell lines by lipopolysaccharide and interferon-gamma causes NO-mediated decreases in mitochondrial and cellular function. The European Journal of Neuroscience, 13 (3). pp. 529-38. ISSN 0953-816X

NAA

Brooks, Keith J and Hargreaves, Iain and Bhakoo, Kishore and Sellwood, Mark and O'Brien, Francis and Noone, Martina and Sakata, Yasuko and Cady, Ernest and Wylezinska, Marzena and Thornton, John and Ordidge, Roger and Nguyen, Quyen and Clemence, Matthew and Wyatt, John and Bates, Timothy E. (2002) Delayed hypothermia prevents decreases in N-acetylaspartate and reduced glutathione in the cerebral cortex of the neonatal pig following transient hypoxia-ischaemia. Neurochemical Research, 27 (12). pp. 1599-604. ISSN 0364-3190

NMR

Murphy, Elizabeth J. and Bates, Timothy E. and Williams, Stephen R. and Watson, Tracey and Brindle, Kevin M. and Rajagopalan, Bheeshma and Radda, George K. (1992) Endoplasmic reticulum: the major contributor to the PDE peak in hepatic 31P-NMR spectra at low magnetic field strengths. Biochimica et biophysica acta: biomembranes, 1111 (1). pp. 51-58. ISSN 0005-2736

NMR Spectroscopy

Bakken, Inger J. and Sonnewald, Ursula and Clark, John B. and Bates, Timothy E. (1997) [U-13C]glutamate metabolism in rat brain mitochondria reveals malic enzyme activity. Neuroreport, 8 (7). pp. 1567-1570. ISSN 0959-4965

Brooks, K. J. and Clark, J. B. and Bates, T. E. (1996) Assessment of energy metabolism in the developing brain following aglycemic hypoxia by 1H and 31P NMR. Neurochemical Research, 21 (9). pp. 1089-1095. ISSN 0364-3190

Gadian, D. G. and Williams, S. R. and Bates, T. E. and Kauppinen, R. A. (1993) NMR spectroscopy: current status and future possibilities. Acta neurochirurgica. Supplementum, 57 . pp. 1-8. ISSN 0065-1419

NMR spectroscopy

Dagnelie, P. C. and Bell, J. D. and Williams, S. C. and Bates, T. E. and Abel, P. D. and Foster, C. S. (1993) Altered phosphorylation status, phospholipid metabolism and gluconeogenesis in the host liver of rats with prostate cancer: a 31P magnetic resonance spectroscopy study. British Journal of Cancer, 67 (6). pp. 1303-1309. ISSN 0007-0920

Dagnelie, Pieter C. and Bell, Jimmy D. and Williams, Steve C. and Bates, Timothy E. and Abel, Paul D. and Foster, Christopher S. (1994) Effect of fish oil on cancer cachexia and host liver metabolism in rats with prostate tumors. Lipids, 29 (3). pp. 195-203. ISSN 0024-4201

NO

Calabrese, V. and Bates, T. E. and Stella, A. M. (2000) NO synthase and NO-dependent signal pathways in brain aging and neurodegenerative disorders: the role of oxidant/antioxidant balance. Neurochemical Research, 25 (9-10). pp. 1315-41. ISSN 0364-3190

Calabrese, Vittorio and Scapagnini, Giovanni and Ravagna, Agrippino and Bella, Rita and Foresti, Roberta and Bates, Timothy E. and Giuffrida Stella, Anna-Maria and Pennisi, Giovanni (2002) Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels. Journal of Neuroscience Research, 70 (4). pp. 580-7. ISSN 0360-4012

Cooper, Chris E. and Davies, Nathan A. and Psychoulis, Minas and Canevari, Laura and Bates, Tim E. and Dobbie, Michael S. and Casley, Christopher S. and Sharpe, Martyn A. (2003) Nitric oxide and peroxynitrite cause irreversible increases in the K(m) for oxygen of mitochondrial cytochrome oxidase: in vitro and in vivo studies. Biochimica et Biophysica Acta: general subjects, 1607 (1). pp. 27-34. ISSN 0006-3002

Keelan, J. and Brand, M. P. and Bates, T. E. and Land, J. M. and Clark, J. B. and Heales, S. J. (1996) Nitric oxide and antioxidant status in glucose and oxygen deprived neonatal and adult rat brain synaptosomes. Neurochemical Research, 21 (8). pp. 923-7. ISSN 0364-3190

Moss, David W. and Bates, Timothy E. (2001) Activation of murine microglial cell lines by lipopolysaccharide and interferon-gamma causes NO-mediated decreases in mitochondrial and cellular function. The European Journal of Neuroscience, 13 (3). pp. 529-38. ISSN 0953-816X

NOS

Bates, T. E and Loesch, A. and Burnstock, G. and Clark, J. B. (1995) Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver. Biochemical and biophysical research communications, 213 (3). pp. 896-900. ISSN 0006-291X

Bates, T. E. and Loesch, A. and Burnstock, G. and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochemical and biophysical research communications, 218 (1). pp. 40-44. ISSN 0006-291X

Calabrese, V. and Bates, T. E. and Stella, A. M. (2000) NO synthase and NO-dependent signal pathways in brain aging and neurodegenerative disorders: the role of oxidant/antioxidant balance. Neurochemical Research, 25 (9-10). pp. 1315-41. ISSN 0364-3190

Calabrese, Vittorio and Scapagnini, Giovanni and Ravagna, Agrippino and Bella, Rita and Foresti, Roberta and Bates, Timothy E. and Giuffrida Stella, Anna-Maria and Pennisi, Giovanni (2002) Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels. Journal of Neuroscience Research, 70 (4). pp. 580-7. ISSN 0360-4012

Moss, David W. and Bates, Timothy E. (2001) Activation of murine microglial cell lines by lipopolysaccharide and interferon-gamma causes NO-mediated decreases in mitochondrial and cellular function. The European Journal of Neuroscience, 13 (3). pp. 529-38. ISSN 0953-816X

Neoplasm Proteins

Hatfield, E. C. I. and Hawkes, C. J. and Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Hawkes, C. J. and Wasmeier, C. and Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Nerve Tissue Proteins

Christie, M. R. (1993) Characterization of distinct islet protein auto antigens associated with type 1 diabetes. Autoimmunity, 15 (s1). pp. 1-3. ISSN 0891-6934

Nitric Oxide Synthase

Bates, T. E and Loesch, A. and Burnstock, G. and Clark, J. B. (1995) Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver. Biochemical and biophysical research communications, 213 (3). pp. 896-900. ISSN 0006-291X

Bates, T. E. and Loesch, A. and Burnstock, G. and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochemical and biophysical research communications, 218 (1). pp. 40-44. ISSN 0006-291X

Brooks, K. J. and Hargreaves, I. P. and Bates, T. E. (2000) Nitric-oxide-induced inhibition of mitochondrial complexes following aglycaemic hypoxia in neonatal cortical rat brain slices. Developmental Neuroscience, 22 (5-6). pp. 359-65. ISSN 0378-5866

Calabrese, V. and Bates, T. E. and Stella, A. M. (2000) NO synthase and NO-dependent signal pathways in brain aging and neurodegenerative disorders: the role of oxidant/antioxidant balance. Neurochemical Research, 25 (9-10). pp. 1315-41. ISSN 0364-3190

Nitric oxide

Calabrese, Vittorio and Scapagnini, Giovanni and Ravagna, Agrippino and Bella, Rita and Foresti, Roberta and Bates, Timothy E. and Giuffrida Stella, Anna-Maria and Pennisi, Giovanni (2002) Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels. Journal of Neuroscience Research, 70 (4). pp. 580-7. ISSN 0360-4012

Cooper, Chris E. and Davies, Nathan A. and Psychoulis, Minas and Canevari, Laura and Bates, Tim E. and Dobbie, Michael S. and Casley, Christopher S. and Sharpe, Martyn A. (2003) Nitric oxide and peroxynitrite cause irreversible increases in the K(m) for oxygen of mitochondrial cytochrome oxidase: in vitro and in vivo studies. Biochimica et Biophysica Acta: general subjects, 1607 (1). pp. 27-34. ISSN 0006-3002

Nitric oxide synthase

Calabrese, Vittorio and Scapagnini, Giovanni and Ravagna, Agrippino and Bella, Rita and Foresti, Roberta and Bates, Timothy E. and Giuffrida Stella, Anna-Maria and Pennisi, Giovanni (2002) Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels. Journal of Neuroscience Research, 70 (4). pp. 580-7. ISSN 0360-4012

Nuclear Family

Christie, Michael R. and Roll, Ursula and Payton, Mark A. and Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Gorus, F. K. and Goubert, P. and Semakula, C. and Vandewalle, C. L. and De Schepper, J. and Scheen, A. and Christie, Michael R. and Pipeleers, D. G. (1997) IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia, 40 (1). pp. 95-99. ISSN 0012-186X

Hawkes, C. J. and Wasmeier, C. and Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Roll, U. and Christie, M. R. and Fuchtenbusch, M. and Payton, M. A. and Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Roll, U. and Christie, M. R. and Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

Organ Preservation Solutions

Huang, Guo Cai and Zhao, Min and Jones, Peter and Persaud, Shanta and Ramracheya, Reshma and Lobner, Kristian and Christie, Michael R. and Banga, J. Paul and Peakman, Mark and Sirinivsan, Parthi and Rela, Mohammed and Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Organ Specificity

Christie, M. R. (1993) Characterization of distinct islet protein auto antigens associated with type 1 diabetes. Autoimmunity, 15 (s1). pp. 1-3. ISSN 0891-6934

Morgenthaler, N. G. and Seissler, J. and Achenbach, P. and Glawe, D. and Payton, M. and Meinck, H.-M. and Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Osmolar Concentration

Christie, M. R. and Daneman, D. and Champagne, P. and Delovitch, T. L. (1990) Persistence of serum antibodies to 64,000-Mr islet cell protein after onset of type I diabetes. Diabetes, 39 (6). pp. 653-656. ISSN 0012-1797

Ovarian Neoplasms

Wagner, R. and McNally, J. M. and Bonifacio, E. and Genovese, S. and Foulis, A. and McGill, M. and Christie, M. R. and Betterle, C. and Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

Oxidative Phosphorylation

Bates, T. E and Loesch, A. and Burnstock, G. and Clark, J. B. (1995) Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver. Biochemical and biophysical research communications, 213 (3). pp. 896-900. ISSN 0006-291X

Oxidative Stress

Heales, S. J. and Davies, S. E. and Bates, T. E. and Clark, J. B. (1995) Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration. Neurochemical research, 20 (1). pp. 31-38. ISSN 0364-3190

Oxidative phsphorylation

Bates, Timothy E. and Strangward, Maria and Keelan, Julia and Davey, Gavin P. and Munro, Peter M. G. and Clark, John B. (1996) Inhibition of N-acetylaspartate production: implications for 1H MRS studies in vivo. Neuroreport, 7 (8). pp. 1397-1400. ISSN 0959-4965

Oxidative stress

Calabrese, V. and Scapagnini, G. and Catalano, C. and Bates, T. E. and Dinotta, F. and Micali, G. and Giuffrida Stella, A. M. (2001) Induction of heat shock protein synthesis in human skin fibroblasts in response to oxidative stress: regulation by a natural antioxidant from rosemary extract. International Journal of Tissue Reactions, 23 (2). pp. 51-8. ISSN 0250-0868

PBN

Kuroda, Satoshi and Katsura, Ken-ichiro and Hillered, Lars and Bates, Timothy E. and Siesjö, Bo K. (1996) Delayed treatment with alpha-phenyl-N-tert-butyl nitrone (PBN) attenuates secondary mitochondrial dysfunction after transient focal cerebral ischemia in the rat. Neurobiology of Disease, 3 (2). pp. 149-157. ISSN 0969-9961

Pancreas

Zhao, M. and Amiel, S. A. and Christie, Michael R. and Rela, M. and Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Pancreas Transplantation

Zhao, M. and Amiel, S. A. and Christie, Michael R. and Rela, M. and Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Pancreatic Neoplasms

Hawkes, C. J. and Wasmeier, C. and Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Parkinson's disease

Rosin, Claudia and Colombo, Sergio and Calver, Andrew A. and Bates, Timothy E. and Skaper, Stephen D. (2005) Dopamine D2 and D3 receptor agonists limit oligodendrocyte injury caused by glutamate oxidative stress and oxygen/glucose deprivation. Glia, 52 (4). pp. 336-343. ISSN 0894-1491

Peptide Fragments

Bearzatto, Massimo and Naserke, Heike and Piquer, Sandra and Koczwara, Kerstin and Lampasona, Vito and Williams, Alistair and Christie, Michael R. and Bingley, Polly J. and Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Christie, M. R. and Hollands, J. A. and Brown, T. J. and Michelsen, B. K. and Delovitch, T. L. (1993) Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. Journal of Clinical Investigation, 92 (1). pp. 240-248. ISSN 0021-9738

Christie, M. R. and Tun, R. Y. M. and Lo, S. S. S. and Cassidy, D. and Brown, T. J. and Hollands, J. and Shattock, M. and Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Desai, M.a and Cull, C.A.b and Horton, V.A.a and Christie, M.R.c and Bonifacio, E.d and Lampasona, V.d and Bingley, P.J.e and Levy, J.C.a and Mackay, I.R.f and Zimmet, P.g and Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Hatfield, E. C. I. and Hawkes, C. J. and Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Hawkes, C. J. and Schloot, N. C. and Marks, J. and Willemen, S. J. M. and Drijfhout, J. W. and Mayer, E. K. and Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

Payton, M. A. and Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Peptide Mapping

Christie, M. R. and Vohra, G. and Champagne, P. and Daneman, D. and Delovitch, T. L. (1990) Distinct antibody specificities to a 64-kD islet cell antigen in Type 1 diabetes as revealed by trypsin treatment. Journal of Experimental Medicine, 172 (3). pp. 789-794. ISSN 0022-1007

Peptides

Tremble, Jennifer and Morgenthaler, Nils G. and Vlug, Arjen and Powers, Alvin C. and Christie, Michael R. and Scherbaum, Werner A. and Banga, J. Paul (1997) Human B cells secreting immunoglobulin G to glutamic acid decarboxylase- 65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes. Journal of Clinical Endocrinology and Metabolism, 82 (8). pp. 2664-2670. ISSN 0021-972X

Phosphodiester

Murphy, Elizabeth J. and Bates, Timothy E. and Williams, Stephen R. and Watson, Tracey and Brindle, Kevin M. and Rajagopalan, Bheeshma and Radda, George K. (1992) Endoplasmic reticulum: the major contributor to the PDE peak in hepatic 31P-NMR spectra at low magnetic field strengths. Biochimica et biophysica acta: biomembranes, 1111 (1). pp. 51-58. ISSN 0005-2736

Placebos

Christie, Michael R. and Molvig, Jens and Hawkes, Charlotte J. and Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

Plasmids

Zhao, M. and Amiel, S. A. and Christie, Michael R. and Rela, M. and Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Polyendocrinopathies, Autoimmune

Gylling, Mikhail and Tuomi, Tiinamaija and Bjorses, Petra and Kontiainen, Sirkka and Partanen, Jukka and Christie, Michael R. and Knip, Mikael and Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

Morgenthaler, N. G. and Seissler, J. and Achenbach, P. and Glawe, D. and Payton, M. and Meinck, H.-M. and Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Wagner, R. and Genovese, S. and Bosi, E. and Becker, F. and Bingley, P. J. and Bonifacio, E. and Miles, K. A. and Christie, Michael and Bottazzo, G. F. and Gale, E. A. M. (1994) Slow metabolic deterioration towards diabetes in islet cell antibody positive patients with autoimmune polyendocrine disease. Diabetologia, 37 (4). pp. 365-371. ISSN 0012-186X

Wagner, R. and McNally, J. M. and Bonifacio, E. and Genovese, S. and Foulis, A. and McGill, M. and Christie, M. R. and Betterle, C. and Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

Polymerase Chain Reaction

Payton, M. A. and Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Polymorphism, Genetic

Winnock, Frederic and Christie, Michael R. and Batstra, Manou R. and Aanstoot, Henk-Jan and Weets, Ilse and Decochez, Katelijn and Jopart, Philippe and Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

Precipitin Tests

Baekkeskov, S. and Warnock, G. and Christie, M. and Rajotte, R.V. and Larsen, P.M. and Fey, S. (1989) Revelation of specificity of 64K autoantibodies in IDDM serums by high-resolution 2-D gel electrophoresis. Unambiguous identification of 64K target antigen. Diabetes, 38 (9). pp. 1133-1141. ISSN 0012-1797

Christie, M. R. (1993) Characterization of distinct islet protein auto antigens associated with type 1 diabetes. Autoimmunity, 15 (s1). pp. 1-3. ISSN 0891-6934

Christie, M. R. and Daneman, D. and Champagne, P. and Delovitch, T. L. (1990) Persistence of serum antibodies to 64,000-Mr islet cell protein after onset of type I diabetes. Diabetes, 39 (6). pp. 653-656. ISSN 0012-1797

Morgenthaler, N. G. and Löbner, K. and Morgenthaler, U. Y. and Christie, M. R. and Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Prediabetic State

Christie, M. R. and Tun, R. Y. M. and Lo, S. S. S. and Cassidy, D. and Brown, T. J. and Hollands, J. and Shattock, M. and Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Winnock, Frederic and Christie, Michael R. and Batstra, Manou R. and Aanstoot, Henk-Jan and Weets, Ilse and Decochez, Katelijn and Jopart, Philippe and Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

Predictive Value of Tests

Bingley, P. J. and Christie, M. R. and Bonifacio, E. and Bonfanti, R. and Shattock, M. and Fonte, M.-T. and Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Christie, M. R. and Genovese, S. and Cassidy, D. and Bosi, E. and Brown, T. J. and Lai, M. and Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

Christie, Michael R. and Molvig, Jens and Hawkes, Charlotte J. and Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

Desai, M.a and Cull, C.A.b and Horton, V.A.a and Christie, M.R.c and Bonifacio, E.d and Lampasona, V.d and Bingley, P.J.e and Levy, J.C.a and Mackay, I.R.f and Zimmet, P.g and Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Hawa, M. and Rowe, R. and Lan, M. S. and Notkins, A. L. and Pozzilli, P. and Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Winnock, Frederic and Christie, Michael R. and Batstra, Manou R. and Aanstoot, Henk-Jan and Weets, Ilse and Decochez, Katelijn and Jopart, Philippe and Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

Pregnancy

Damanhouri, L. H. and Dromey, J. A. and Christie, Michael R. and Nasrat, H. A. and Ardawi, M. S. M. and Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Roll, U. and Christie, M. R. and Fuchtenbusch, M. and Payton, M. A. and Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Pregnancy in Diabetics

Roll, U. and Christie, M. R. and Fuchtenbusch, M. and Payton, M. A. and Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Prevalence

Gorus, F. K. and Goubert, P. and Semakula, C. and Vandewalle, C. L. and De Schepper, J. and Scheen, A. and Christie, Michael R. and Pipeleers, D. G. (1997) IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia, 40 (1). pp. 95-99. ISSN 0012-186X

Primary care

Siriwardena, Niro (2011) Quality in primary care 2011 [Editorial]. Quality in Primary Care, 19 (6). pp. 345-346. ISSN 1479-1072

Prospective Studies

Hawa, M. and Rowe, R. and Lan, M. S. and Notkins, A. L. and Pozzilli, P. and Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Roll, U. and Christie, M. R. and Fuchtenbusch, M. and Payton, M. A. and Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Prostate cancer

Dagnelie, Pieter C. and Bell, Jimmy D. and Williams, Steve C. and Bates, Timothy E. and Abel, Paul D. and Foster, Christopher S. (1994) Effect of fish oil on cancer cachexia and host liver metabolism in rats with prostate tumors. Lipids, 29 (3). pp. 195-203. ISSN 0024-4201

Protein Footprinting

Bearzatto, Massimo and Naserke, Heike and Piquer, Sandra and Koczwara, Kerstin and Lampasona, Vito and Williams, Alistair and Christie, Michael R. and Bingley, Polly J. and Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Protein-Tyrosine-Phosphatase

Bearzatto, Massimo and Naserke, Heike and Piquer, Sandra and Koczwara, Kerstin and Lampasona, Vito and Williams, Alistair and Christie, Michael R. and Bingley, Polly J. and Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Christie, M. R. (1996) Islet cell autoantigens in type 1 diabetes. European Journal of Clinical Investigation, 26 (10). pp. 827-838. ISSN 0014-2972

Christie, Michael R. and Roll, Ursula and Payton, Mark A. and Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Hatfield, E. C. I. and Hawkes, C. J. and Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Hawa, M. and Rowe, R. and Lan, M. S. and Notkins, A. L. and Pozzilli, P. and Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Hawkes, C. J. and Schloot, N. C. and Marks, J. and Willemen, S. J. M. and Drijfhout, J. W. and Mayer, E. K. and Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

Hawkes, C. J. and Wasmeier, C. and Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Morgenthaler, N. G. and Löbner, K. and Morgenthaler, U. Y. and Christie, M. R. and Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Morgenthaler, N. G. and Seissler, J. and Achenbach, P. and Glawe, D. and Payton, M. and Meinck, H.-M. and Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Payton, M. A. and Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Piquer, Sandra and Valera, Lionel and Lampasona, Vito and Jardin-Watelet, Benedicte and Roche, Stephanie and Granier, Claude and Roquet, Francoise and Christie, Michael R. and Giordano, Tiziana and Malosio, Maria-Luisa and Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

Roll, U. and Christie, M. R. and Fuchtenbusch, M. and Payton, M. A. and Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Seissler, J. and Morgenthaler, N. G. and Achenbach, P. and Lampeter, E .F. and Glawe, D. and Payton, M. and Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

Proteins

Christie, M. R. and Daneman, D. and Champagne, P. and Delovitch, T. L. (1990) Persistence of serum antibodies to 64,000-Mr islet cell protein after onset of type I diabetes. Diabetes, 39 (6). pp. 653-656. ISSN 0012-1797

RCT

Middleton, Geoff and Keegan, Richard and Smith, Mark F. and Alkhatib, Ahmed and Klonizakis, Markos (2015) Implementing a Mediterranean diet intervention into a RCT: lessons learned from a non-Mediterranean based country. Journal of Nutrition, Health and Aging, 19 (7). pp. 771-777. ISSN 1279-7707

RUNX1

Li, Donglan and Sinha, Kislay K. and Hay, Maher A. and Rinaldi, Ciro R. and Saunthararajah, Yogen and Nucifora, Giuseppina (2007) RUNX1-RUNX1 homodimerization modulates RUNX1 activity and function. The Journal of Biological Chemistry, 282 (18). pp. 13542-51. ISSN 0021-9258

RUNx1

Senyuk, Vitalyi and Sinha, Kislay K. and Li, Donglan and Rinaldi, Ciro R. and Yanamandra, Sastry and Nucifora, Giuseppina (2007) Repression of RUNX1 activity by EVI1: a new role of EVI1 in leukemogenesis. Cancer research, 67 (12). pp. 5658-5666. ISSN 1538-7445

Rabbits

Hawkes, C. J. and Wasmeier, C. and Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Radioimmunoprecipitation Assay

Damanhouri, L. H. and Dromey, J. A. and Christie, Michael R. and Nasrat, H. A. and Ardawi, M. S. M. and Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Radioligand Assay

Morgenthaler, N. G. and Löbner, K. and Morgenthaler, U. Y. and Christie, M. R. and Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Seissler, J. and Morgenthaler, N. G. and Achenbach, P. and Lampeter, E .F. and Glawe, D. and Payton, M. and Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

Raffinose

Huang, Guo Cai and Zhao, Min and Jones, Peter and Persaud, Shanta and Ramracheya, Reshma and Lobner, Kristian and Christie, Michael R. and Banga, J. Paul and Peakman, Mark and Sirinivsan, Parthi and Rela, Mohammed and Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Rats

Baekkeskov, S. and Warnock, G. and Christie, M. and Rajotte, R.V. and Larsen, P.M. and Fey, S. (1989) Revelation of specificity of 64K autoantibodies in IDDM serums by high-resolution 2-D gel electrophoresis. Unambiguous identification of 64K target antigen. Diabetes, 38 (9). pp. 1133-1141. ISSN 0012-1797

Christie, M. R. (1993) Characterization of distinct islet protein auto antigens associated with type 1 diabetes. Autoimmunity, 15 (s1). pp. 1-3. ISSN 0891-6934

Christie, M. R. and Pipeleers, D. G. and Lernmark, A. and Baekkeskov, S. (1990) Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes. Journal of Biological Chemistry, 265 (1). pp. 376-381. ISSN 0021-9258

Christie, M. R. and Vohra, G. and Champagne, P. and Daneman, D. and Delovitch, T. L. (1990) Distinct antibody specificities to a 64-kD islet cell antigen in Type 1 diabetes as revealed by trypsin treatment. Journal of Experimental Medicine, 172 (3). pp. 789-794. ISSN 0022-1007

Christie, Michael and Brown, T. J. and Cassidy, D. (1992) Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme. Diabetologia, 35 (4). pp. 380-384. ISSN 0012-186X

Christie, Michael and Landin-Olsson, M. and Sundkvist, G. and Dahlquist, G. and Lernmark, A. and Baekkeskov, S. (1988) Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes. Diabetologia, 31 (8). pp. 597-602. ISSN 0012-186X

Hansen, W.A. and Christie, M.R. and Kahn, R. and Norgaard, A. and Abel, I. and Petersen, A.M. and Jorgensen, D.W. and Baekkeskov, S. and Nielsen, J.H. and Lernmark, A. and Egeberg, J. and Richter-Olesen, H. and Grainger, T. and Kristensen, J.K. and Brynitz, S. and Bilde, T. (1989) Supravital dithizone staining in the isolation of human and rat pancreatic islets. Diabetes Research, 10 (2). pp. 53-57. ISSN 0265-5985

Hawkes, C. J. and Wasmeier, C. and Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Payton, M. A. and Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Roll, U. and Christie, M. R. and Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

Rats, Inbred Strains

Baekkeskov, S. and Warnock, G. and Christie, M. and Rajotte, R.V. and Larsen, P.M. and Fey, S. (1989) Revelation of specificity of 64K autoantibodies in IDDM serums by high-resolution 2-D gel electrophoresis. Unambiguous identification of 64K target antigen. Diabetes, 38 (9). pp. 1133-1141. ISSN 0012-1797

Christie, M. R. and Pipeleers, D. G. and Lernmark, A. and Baekkeskov, S. (1990) Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes. Journal of Biological Chemistry, 265 (1). pp. 376-381. ISSN 0021-9258

Christie, Michael and Brown, T. J. and Cassidy, D. (1992) Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme. Diabetologia, 35 (4). pp. 380-384. ISSN 0012-186X

Christie, Michael and Landin-Olsson, M. and Sundkvist, G. and Dahlquist, G. and Lernmark, A. and Baekkeskov, S. (1988) Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes. Diabetologia, 31 (8). pp. 597-602. ISSN 0012-186X

Rats, Wistar

Roll, U. and Christie, M. R. and Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

Recombinant Fusion Proteins

Bearzatto, Massimo and Naserke, Heike and Piquer, Sandra and Koczwara, Kerstin and Lampasona, Vito and Williams, Alistair and Christie, Michael R. and Bingley, Polly J. and Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Recombinant Proteins

Hatfield, E. C. I. and Hawkes, C. J. and Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Hawkes, C. J. and Wasmeier, C. and Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Payton, M. A. and Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Seissler, J. and Morgenthaler, N. G. and Achenbach, P. and Lampeter, E .F. and Glawe, D. and Payton, M. and Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

Recombinant Proteins, Escherichia coli

Morgenthaler, N. G. and Löbner, K. and Morgenthaler, U. Y. and Christie, M. R. and Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Reference Values

Christie, M. R. and Vohra, G. and Champagne, P. and Daneman, D. and Delovitch, T. L. (1990) Distinct antibody specificities to a 64-kD islet cell antigen in Type 1 diabetes as revealed by trypsin treatment. Journal of Experimental Medicine, 172 (3). pp. 789-794. ISSN 0022-1007

Christie, Michael and Brown, T. J. and Cassidy, D. (1992) Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme. Diabetologia, 35 (4). pp. 380-384. ISSN 0012-186X

Christie, Michael and Landin-Olsson, M. and Sundkvist, G. and Dahlquist, G. and Lernmark, A. and Baekkeskov, S. (1988) Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes. Diabetologia, 31 (8). pp. 597-602. ISSN 0012-186X

Hawkes, C. J. and Wasmeier, C. and Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Payton, M. A. and Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Roll, U. and Christie, M. R. and Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

Registries

Winnock, Frederic and Christie, Michael R. and Batstra, Manou R. and Aanstoot, Henk-Jan and Weets, Ilse and Decochez, Katelijn and Jopart, Philippe and Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

Regression Analysis

Christie, M. R. and Tun, R. Y. M. and Lo, S. S. S. and Cassidy, D. and Brown, T. J. and Hollands, J. and Shattock, M. and Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Reperfusion

Almeida, Angeles and Allen, Kathryn L. and Bates, TImothy E. and Clark, John B. (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. Journal of neurochemistry, 65 (4). pp. 1698-1703. ISSN 0022-3042

Reperfusion injury

Almeida, Angeles and Allen, Kathryn L. and Bates, TImothy E. and Clark, John B. (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. Journal of neurochemistry, 65 (4). pp. 1698-1703. ISSN 0022-3042

Sammut, Ivan A. and Jayakumar, Jay and Latif, Najmi and Rothery, Stephen and Severs, Nicholas J. and Smolenski, Ryszard T. and Bates, Timothy E. and Yacoub, Magdi H. (2001) Heat stress contributes to the enhancement of cardiac mitochondrial complex activity. The American Journal of Pathology, 158 (5). pp. 1821-31. ISSN 0002-9440

Reproducibility

Klonizakis, Markos and Manning, Gillian and Donnelly, Richard (2011) Assessment of lower limb microcirculation: exploring the reproducibility and clinical application of laser doppler techniques. Skin Pharmacology and Physiology: Journal of Pharmacological and Biophysical Research, 24 (3). pp. 136-143. ISSN 1660-5527

Tew, G. and Klonizakis, Markos and Moss, J. and Ruddock, A. D. and Saxton, J. M. and Hodges, G. J. (2011) Reproducibility of cutaneous thermal hyperaemia assessed by laser Doppler flowmetry in young and older adults. Microvascular Research, 81 (2). pp. 177-182. ISSN 0026-2862

Reproducibility of Results

Christie, Michael R. and Roll, Ursula and Payton, Mark A. and Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Morgenthaler, N. G. and Seissler, J. and Achenbach, P. and Glawe, D. and Payton, M. and Meinck, H.-M. and Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Respiratory chain

Almeida, Angeles and Allen, Kathryn L. and Bates, TImothy E. and Clark, John B. (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. Journal of neurochemistry, 65 (4). pp. 1698-1703. ISSN 0022-3042

Reverse Transcriptase Polymerase Chain Reaction

Zhao, M. and Amiel, S. A. and Christie, Michael R. and Rela, M. and Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Risk

Gillespie, Kathleen M. and Bain, Steven C. and Barnett, Anthony H. and Bingley, Polly J. and Christie, Michael R. and Gill, Geoffrey V. and Gale, Edwin A. M. (2004) The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. The Lancet, 364 (9446). pp. 1699-1700. ISSN 0140-6736

Risk Assessment

Christie, Michael R. and Roll, Ursula and Payton, Mark A. and Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Risk Factors

Bearzatto, Massimo and Naserke, Heike and Piquer, Sandra and Koczwara, Kerstin and Lampasona, Vito and Williams, Alistair and Christie, Michael R. and Bingley, Polly J. and Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Christie, Michael R. and Roll, Ursula and Payton, Mark A. and Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Seissler, J. and Morgenthaler, N. G. and Achenbach, P. and Lampeter, E .F. and Glawe, D. and Payton, M. and Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

S-nitrosothiols

Calabrese, Vittorio and Scapagnini, Giovanni and Ravagna, Agrippino and Bella, Rita and Foresti, Roberta and Bates, Timothy E. and Giuffrida Stella, Anna-Maria and Pennisi, Giovanni (2002) Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels. Journal of Neuroscience Research, 70 (4). pp. 580-7. ISSN 0360-4012

SB366791

Athanasiou, Andriani and Smith, Paul A. and Vakilpour, Sara and Kumaran, Nethia M. and Turner, Amy E. and Bagiokou, Dimitra and Layfield, Robert and Ray, David E. and Westwell, Andrew D. and Alexander, Stephen P. H. and Kendall, David A. and Lobo, Dileep N. and Watson, Susan A. and Lophatanon, Artitaya and Muir, Kenneth A. and Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

SCID mouse

Zhao, M. and Amiel, S. A. and Christie, Michael R. and Rela, M. and Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Zhao, M. and Christie, M.R. and Heaton, N. and George, S. and Amiel, S. and Huang, G.C. (2002) Amelioration of streptozotocin-induced diabetes in mice using human islet cells derived from long-term culture in vitro. Transplantation, 73 (9). pp. 1454-1460. ISSN 0041-1337

SCID mouse, Adenosine

Huang, Guo Cai and Zhao, Min and Jones, Peter and Persaud, Shanta and Ramracheya, Reshma and Lobner, Kristian and Christie, Michael R. and Banga, J. Paul and Peakman, Mark and Sirinivsan, Parthi and Rela, Mohammed and Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Saudi Arabia

Damanhouri, L. H. and Dromey, J. A. and Christie, Michael R. and Nasrat, H. A. and Ardawi, M. S. M. and Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Saudi Arabia, Adult

Damanhouri, L. H. and Dromey, J. A. and Christie, Michael R. and Nasrat, H. A. and Ardawi, M. S. M. and Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Sensitivity and Specificity

Bingley, P. J. and Christie, M. R. and Bonifacio, E. and Bonfanti, R. and Shattock, M. and Fonte, M.-T. and Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Morgenthaler, N. G. and Seissler, J. and Achenbach, P. and Glawe, D. and Payton, M. and Meinck, H.-M. and Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Sex Characteristics

Winnock, Frederic and Christie, Michael R. and Batstra, Manou R. and Aanstoot, Henk-Jan and Weets, Ilse and Decochez, Katelijn and Jopart, Philippe and Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

Skeletal Muscle

Bates, T. E. and Loesch, A. and Burnstock, G. and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochemical and biophysical research communications, 218 (1). pp. 40-44. ISSN 0006-291X

Skin blood flow

Klonizakis, Markos (2012) Studying the cutaneous microcirculatory response during upper-limb exercise in healthy, older, sedentary people. Clinical Hemorheology and Microcirculation, 51 (1). pp. 69-75. ISSN 1386-0281

Tew, G. and Klonizakis, Markos and Moss, J. and Ruddock, A. D. and Saxton, J. M. and Hodges, G. J. (2011) Reproducibility of cutaneous thermal hyperaemia assessed by laser Doppler flowmetry in young and older adults. Microvascular Research, 81 (2). pp. 177-182. ISSN 0026-2862

Tew, G. and Klonizakis, Markos and Moss, J. and Ruddock, A. and Saxton, J. M. and Hodges, G. (2010) Role of sensory nerves in the rapid cutaneous vasodilator response to local heating in young and older endurance-trained and untrained men. In: 9th World Congress on Microcirculation, 26 - 28 September 2010, Maison de la Chimie, Paris.

Tew, G. A. and Saxton, J. M. and Klonizakis, Markos and Moss, J. and Ruddock, A. D. and Hodges, G. J. (2011) Aging and aerobic fitness affect the contribution of noradrenergic sympathetic nerves to the rapid cutaneous vasodilator response to local heating. Journal of Applied Physiology, 110 (5). pp. 1264-1270. ISSN 8750-7587

Somatostatin

Wagner, R. and McNally, J. M. and Bonifacio, E. and Genovese, S. and Foulis, A. and McGill, M. and Christie, M. R. and Betterle, C. and Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

Stiff-Person Syndrome

Christie, M. R. and Genovese, S. and Cassidy, D. and Bosi, E. and Brown, T. J. and Lai, M. and Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

Morgenthaler, N. G. and Seissler, J. and Achenbach, P. and Glawe, D. and Payton, M. and Meinck, H.-M. and Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Sulfur Radioisotopes

Christie, Michael and Landin-Olsson, M. and Sundkvist, G. and Dahlquist, G. and Lernmark, A. and Baekkeskov, S. (1988) Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes. Diabetologia, 31 (8). pp. 597-602. ISSN 0012-186X

Support, Non-U.S. Gov't

Baekkeskov, S. and Warnock, G. and Christie, M. and Rajotte, R.V. and Larsen, P.M. and Fey, S. (1989) Revelation of specificity of 64K autoantibodies in IDDM serums by high-resolution 2-D gel electrophoresis. Unambiguous identification of 64K target antigen. Diabetes, 38 (9). pp. 1133-1141. ISSN 0012-1797

Bottazzo, G. F. and Genovese, S. and Bosi, E. and Dean, B. M. and Christie, M. R. and Bonifacio, E. (1991) Novel considerations on the antibody/autoantigen system in type I (insulin-dependent) diabetes mellitus. Annals of Medicine, 23 (4). pp. 453-461. ISSN 0785-3890

Christie, M. R. and Daneman, D. and Champagne, P. and Delovitch, T. L. (1990) Persistence of serum antibodies to 64,000-Mr islet cell protein after onset of type I diabetes. Diabetes, 39 (6). pp. 653-656. ISSN 0012-1797

Christie, M. R. and Genovese, S. and Cassidy, D. and Bosi, E. and Brown, T. J. and Lai, M. and Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

Christie, M. R. and Hollands, J. A. and Brown, T. J. and Michelsen, B. K. and Delovitch, T. L. (1993) Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. Journal of Clinical Investigation, 92 (1). pp. 240-248. ISSN 0021-9738

Christie, M. R. and Pipeleers, D. G. and Lernmark, A. and Baekkeskov, S. (1990) Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes. Journal of Biological Chemistry, 265 (1). pp. 376-381. ISSN 0021-9258

Christie, M. R. and Tun, R. Y. M. and Lo, S. S. S. and Cassidy, D. and Brown, T. J. and Hollands, J. and Shattock, M. and Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Christie, M. R. and Vohra, G. and Champagne, P. and Daneman, D. and Delovitch, T. L. (1990) Distinct antibody specificities to a 64-kD islet cell antigen in Type 1 diabetes as revealed by trypsin treatment. Journal of Experimental Medicine, 172 (3). pp. 789-794. ISSN 0022-1007

Christie, Michael and Brown, T. J. and Cassidy, D. (1992) Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme. Diabetologia, 35 (4). pp. 380-384. ISSN 0012-186X

Christie, Michael and Landin-Olsson, M. and Sundkvist, G. and Dahlquist, G. and Lernmark, A. and Baekkeskov, S. (1988) Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes. Diabetologia, 31 (8). pp. 597-602. ISSN 0012-186X

Hansen, W.A. and Christie, M.R. and Kahn, R. and Norgaard, A. and Abel, I. and Petersen, A.M. and Jorgensen, D.W. and Baekkeskov, S. and Nielsen, J.H. and Lernmark, A. and Egeberg, J. and Richter-Olesen, H. and Grainger, T. and Kristensen, J.K. and Brynitz, S. and Bilde, T. (1989) Supravital dithizone staining in the isolation of human and rat pancreatic islets. Diabetes Research, 10 (2). pp. 53-57. ISSN 0265-5985

Payton, M. A. and Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Roll, U. and Christie, M. R. and Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

Wagner, R. and Genovese, S. and Bosi, E. and Becker, F. and Bingley, P. J. and Bonifacio, E. and Miles, K. A. and Christie, Michael and Bottazzo, G. F. and Gale, E. A. M. (1994) Slow metabolic deterioration towards diabetes in islet cell antibody positive patients with autoimmune polyendocrine disease. Diabetologia, 37 (4). pp. 365-371. ISSN 0012-186X

Support, U.S. Gov't, P.H.S.

Christie, M. R. and Pipeleers, D. G. and Lernmark, A. and Baekkeskov, S. (1990) Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes. Journal of Biological Chemistry, 265 (1). pp. 376-381. ISSN 0021-9258

Christie, Michael and Landin-Olsson, M. and Sundkvist, G. and Dahlquist, G. and Lernmark, A. and Baekkeskov, S. (1988) Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes. Diabetologia, 31 (8). pp. 597-602. ISSN 0012-186X

Hansen, W.A. and Christie, M.R. and Kahn, R. and Norgaard, A. and Abel, I. and Petersen, A.M. and Jorgensen, D.W. and Baekkeskov, S. and Nielsen, J.H. and Lernmark, A. and Egeberg, J. and Richter-Olesen, H. and Grainger, T. and Kristensen, J.K. and Brynitz, S. and Bilde, T. (1989) Supravital dithizone staining in the isolation of human and rat pancreatic islets. Diabetes Research, 10 (2). pp. 53-57. ISSN 0265-5985

Sweden

Christie, Michael and Landin-Olsson, M. and Sundkvist, G. and Dahlquist, G. and Lernmark, A. and Baekkeskov, S. (1988) Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes. Diabetologia, 31 (8). pp. 597-602. ISSN 0012-186X

Synaptic

Almeida, A. and Brooks, K. J. and Sammut, I. and Keelan, J. and Davey, G. P. and Clark, J. B. and Bates, T. E. (1995) Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain. Developmental neuroscience, 17 (4). pp. 212-218. ISSN 0378-5866

Synaptosomal

Almeida, A. and Brooks, K. J. and Sammut, I. and Keelan, J. and Davey, G. P. and Clark, J. B. and Bates, T. E. (1995) Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain. Developmental Neuroscience, 17 (4). pp. 212-218. ISSN 0378-5866

Bates, T. E and Loesch, A. and Burnstock, G. and Clark, J. B. (1995) Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver. Biochemical and biophysical research communications, 213 (3). pp. 896-900. ISSN 0006-291X

Synaptosomes

Allen, Kathryn L. and Almeida, Angeles and Bates, Timothy E. and Clark, John B. (1995) Changes of respiratory chain activity in mitochondrial and synaptosomal fractions isolated from the gerbil brain after graded ischaemia. Journal of neurochemistry, 64 (5). pp. 2222-2229. ISSN 0022-3042

Almeida, A. and Brooks, K. J. and Sammut, I. and Keelan, J. and Davey, G. P. and Clark, J. B. and Bates, T. E. (1995) Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain. Developmental neuroscience, 17 (4). pp. 212-218. ISSN 0378-5866

Keelan, J. and Brand, M. P. and Bates, T. E. and Land, J. M. and Clark, J. B. and Heales, S. J. (1996) Nitric oxide and antioxidant status in glucose and oxygen deprived neonatal and adult rat brain synaptosomes. Neurochemical Research, 21 (8). pp. 923-7. ISSN 0364-3190

Keelan, Julie and Bates, Timothy E. and Clark, John B. (1999) Heightened resistance of the neonatal brain to ischemia-reperfusion involves a lack of mitochondrial damage in the nerve terminal. Brain research, 821 (1). pp. 124-33. ISSN 0006-8993

Keelan, Julie and Bates, Timothy E. and Clark, John B. (1996) Intrasynaptosomal free calcium concentration during rat brain development: effects of hypoxia, aglycaemia, and ischaemia. Journal of neurochemistry, 66 (6). pp. 2460-7. ISSN 0022-3042

T lymphocyte, Adolescent

Hawkes, C. J. and Schloot, N. C. and Marks, J. and Willemen, S. J. M. and Drijfhout, J. W. and Mayer, E. K. and Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

T-Lymphocytes

Hawkes, C. J. and Schloot, N. C. and Marks, J. and Willemen, S. J. M. and Drijfhout, J. W. and Mayer, E. K. and Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

TASTPM

Pardon, Marie-Christine and Sarmad, Sarir and Rattray, Ivan and Bates, Timothy E. and Scullion, Gillian A. and Marsden, Charles A. and Barrett, David A. and Lowe, James and Kendall, David A. (2009) Repeated novel cage exposure-induced improvement of early Alzheimer's-like cognitive and amyloid changes in TASTPM mice is unrelated to changes in brain endocannabinoids levels. Neurobiology of Aging, 30 (7). pp. 1099-1113. ISSN 0197-4580

THC

Athanasiou, Andriani and Clarke, Anna B. and Turner, Amy E. and Kumaran, Nethia M. and Vakilpour, Sara and Smith, Paul A. and Bagiokou, Dimitra and Bradshaw, Tracey D. and Westwell, Andrew D. and Fang, Lin and Lobo, Dileep N. and Constantinescu, Cris S. and Calabrese, Vittorio and Loesch, Andrzej and Alexander, Stephen P. H. and Clothier, Richard H. and Kendall, David A. and Bates, Timothy E. (2007) Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications, 364 (1). pp. 131-137. ISSN 0006-291x

TRPV1

Athanasiou, Andriani and Smith, Paul A. and Vakilpour, Sara and Kumaran, Nethia M. and Turner, Amy E. and Bagiokou, Dimitra and Layfield, Robert and Ray, David E. and Westwell, Andrew D. and Alexander, Stephen P. H. and Kendall, David A. and Lobo, Dileep N. and Watson, Susan A. and Lophatanon, Artitaya and Muir, Kenneth A. and Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

Time Factors

Christie, Michael R. and Molvig, Jens and Hawkes, Charlotte J. and Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

Christie, Michael R. and Roll, Ursula and Payton, Mark A. and Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Desai, M.a and Cull, C.A.b and Horton, V.A.a and Christie, M.R.c and Bonifacio, E.d and Lampasona, V.d and Bingley, P.J.e and Levy, J.C.a and Mackay, I.R.f and Zimmet, P.g and Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Roll, U. and Christie, M. R. and Fuchtenbusch, M. and Payton, M. A. and Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Zhao, M. and Christie, M.R. and Heaton, N. and George, S. and Amiel, S. and Huang, G.C. (2002) Amelioration of streptozotocin-induced diabetes in mice using human islet cells derived from long-term culture in vitro. Transplantation, 73 (9). pp. 1454-1460. ISSN 0041-1337

Tissue Distribution

Christie, M. R. and Pipeleers, D. G. and Lernmark, A. and Baekkeskov, S. (1990) Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes. Journal of Biological Chemistry, 265 (1). pp. 376-381. ISSN 0021-9258

Tissue Survival

Huang, Guo Cai and Zhao, Min and Jones, Peter and Persaud, Shanta and Ramracheya, Reshma and Lobner, Kristian and Christie, Michael R. and Banga, J. Paul and Peakman, Mark and Sirinivsan, Parthi and Rela, Mohammed and Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Tissue and Organ Harvesting

Huang, Guo Cai and Zhao, Min and Jones, Peter and Persaud, Shanta and Ramracheya, Reshma and Lobner, Kristian and Christie, Michael R. and Banga, J. Paul and Peakman, Mark and Sirinivsan, Parthi and Rela, Mohammed and Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Trans-Activators

Zhao, M. and Amiel, S. A. and Christie, Michael R. and Rela, M. and Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Transfection

Zhao, M. and Amiel, S. A. and Christie, Michael R. and Rela, M. and Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Transplantation

Sammut, Ivan A. and Thorniley, Maureen S. and Simpkin, Sandra and Fuller, Barry J. and Bates, Timothy E. and Green, Colin J. (1998) Impairment of hepatic mitochondrial respiratory function following storage and orthotopic transplantation of rat livers. Cryobiology, 36 (1). pp. 49-60. ISSN 0011-2240

Trypsin

Bearzatto, Massimo and Naserke, Heike and Piquer, Sandra and Koczwara, Kerstin and Lampasona, Vito and Williams, Alistair and Christie, Michael R. and Bingley, Polly J. and Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Payton, M. A. and Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Trypsin, Human herpesvirus 4

Tremble, Jennifer and Morgenthaler, Nils G. and Vlug, Arjen and Powers, Alvin C. and Christie, Michael R. and Scherbaum, Werner A. and Banga, J. Paul (1997) Human B cells secreting immunoglobulin G to glutamic acid decarboxylase- 65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes. Journal of Clinical Endocrinology and Metabolism, 82 (8). pp. 2664-2670. ISSN 0021-972X

Twins, Dizygotic

Hawa, M. and Rowe, R. and Lan, M. S. and Notkins, A. L. and Pozzilli, P. and Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Twins, Monozygotic

Christie, M. R. and Tun, R. Y. M. and Lo, S. S. S. and Cassidy, D. and Brown, T. J. and Hollands, J. and Shattock, M. and Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Hawa, M. and Rowe, R. and Lan, M. S. and Notkins, A. L. and Pozzilli, P. and Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Type 1 diabetes

McLaughlin, Kerry A. and Richardson, Carolyn C. and Williams, Stefan and Bonifacio, Ezio and Morgan, Diana and Feltbower, Richard G. and Powell, Michael and Rees Smith, Bernard and Furmaniak, Jadwiga and Christie, Michael R. (2015) Relationships between major epitopes of the IA-2 autoantigen in Type 1 diabetes: implications for determinant spreading. Clinical Immunology, 160 (2). pp. 226-236. ISSN 1521-6616

United Kingdom, Adult

Desai, M.a and Cull, C.A.b and Horton, V.A.a and Christie, M.R.c and Bonifacio, E.d and Lampasona, V.d and Bingley, P.J.e and Levy, J.C.a and Mackay, I.R.f and Zimmet, P.g and Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Vanilloid

Athanasiou, Andriani and Smith, Paul A. and Vakilpour, Sara and Kumaran, Nethia M. and Turner, Amy E. and Bagiokou, Dimitra and Layfield, Robert and Ray, David E. and Westwell, Andrew D. and Alexander, Stephen P. H. and Kendall, David A. and Lobo, Dileep N. and Watson, Susan A. and Lophatanon, Artitaya and Muir, Kenneth A. and Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

Vanilloids

Athanasiou, Andriani and Smith, Paul A. and Vakilpour, Sara and Kumaran, Nethia M. and Turner, Amy E. and Bagiokou, Dimitra and Layfield, Robert and Ray, David E. and Westwell, Andrew D. and Alexander, Stephen P. H. and Kendall, David A. and Lobo, Dileep N. and Watson, Susan A. and Lophatanon, Artitaya and Muir, Kenneth A. and Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

acetyl carnitine

Calabrese, V. and Scapagnini, G. and Catalano, C. and Dinotta, F. and Bates, T. E. and Calvani, M. and Stella, A. M. (2001) Effects of acetyl-L-carnitine on the formation of fatty acid ethyl esters in brain and peripheral organs after short-term ethanol administration in rat. Neurochemical Research, 26 (2). pp. 167-74. ISSN 0364-3190

acetyl-L-carnitine

Mancuso, Cesare and Bates, Timothy E. and Butterfield, D. Allan and Calafato, Stella and Cornelius, Carolin and De Lorenzo, Antonino and Dinkova Kostova, Albena T. and Calabrese, Vittorio (2007) Natural antioxidants in Alzheimer's disease. Expert Opinion on Investigational Drugs, 16 (12). pp. 1921-1931. ISSN 1354-3784

activin A

Zhao, M. and Amiel, S. A. and Christie, Michael R. and Rela, M. and Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

adult

Bearzatto, Massimo and Naserke, Heike and Piquer, Sandra and Koczwara, Kerstin and Lampasona, Vito and Williams, Alistair and Christie, Michael R. and Bingley, Polly J. and Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Bingley, P. J. and Christie, M. R. and Bonifacio, E. and Bonfanti, R. and Shattock, M. and Fonte, M.-T. and Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Christie, Michael and Brown, T. J. and Cassidy, D. (1992) Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme. Diabetologia, 35 (4). pp. 380-384. ISSN 0012-186X

Christie, Michael R. and Molvig, Jens and Hawkes, Charlotte J. and Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

Christie, Michael R. and Roll, Ursula and Payton, Mark A. and Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Gorus, F. K. and Goubert, P. and Semakula, C. and Vandewalle, C. L. and De Schepper, J. and Scheen, A. and Christie, Michael R. and Pipeleers, D. G. (1997) IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia, 40 (1). pp. 95-99. ISSN 0012-186X

Gylling, Mikhail and Tuomi, Tiinamaija and Bjorses, Petra and Kontiainen, Sirkka and Partanen, Jukka and Christie, Michael R. and Knip, Mikael and Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

Hatfield, E. C. I. and Hawkes, C. J. and Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Hawa, M. and Rowe, R. and Lan, M. S. and Notkins, A. L. and Pozzilli, P. and Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Morgenthaler, N. G. and Löbner, K. and Morgenthaler, U. Y. and Christie, M. R. and Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Roll, U. and Christie, M. R. and Fuchtenbusch, M. and Payton, M. A. and Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Roll, U. and Christie, M. R. and Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

Seissler, J. and Morgenthaler, N. G. and Achenbach, P. and Lampeter, E .F. and Glawe, D. and Payton, M. and Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

Winnock, Frederic and Christie, Michael R. and Batstra, Manou R. and Aanstoot, Henk-Jan and Weets, Ilse and Decochez, Katelijn and Jopart, Philippe and Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

age

Tew, G. A. and Saxton, J. M. and Klonizakis, Markos and Moss, J. and Ruddock, A. D. and Hodges, G. J. (2011) Aging and aerobic fitness affect the contribution of noradrenergic sympathetic nerves to the rapid cutaneous vasodilator response to local heating. Journal of Applied Physiology, 110 (5). pp. 1264-1270. ISSN 8750-7587

age distribution

Seissler, J. and Morgenthaler, N. G. and Achenbach, P. and Lampeter, E .F. and Glawe, D. and Payton, M. and Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

aged

Christie, M. R. and Genovese, S. and Cassidy, D. and Bosi, E. and Brown, T. J. and Lai, M. and Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

Christie, Michael and Brown, T. J. and Cassidy, D. (1992) Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme. Diabetologia, 35 (4). pp. 380-384. ISSN 0012-186X

Damanhouri, L. H. and Dromey, J. A. and Christie, Michael R. and Nasrat, H. A. and Ardawi, M. S. M. and Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Desai, M.a and Cull, C.A.b and Horton, V.A.a and Christie, M.R.c and Bonifacio, E.d and Lampasona, V.d and Bingley, P.J.e and Levy, J.C.a and Mackay, I.R.f and Zimmet, P.g and Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Lampeter, E. F. and Kolb, H. and Seifert, I. and Lohmann, D. and Heise, J. W. and Bertrams, J. and Christie, Michael and Kolb-Bachofen, V. (1994) Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity. Diabetologia, 37 (5). pp. 471-475. ISSN 0012-186X

Morgenthaler, N. G. and Löbner, K. and Morgenthaler, U. Y. and Christie, M. R. and Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Morgenthaler, N. G. and Seissler, J. and Achenbach, P. and Glawe, D. and Payton, M. and Meinck, H.-M. and Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Wagner, R. and McNally, J. M. and Bonifacio, E. and Genovese, S. and Foulis, A. and McGill, M. and Christie, M. R. and Betterle, C. and Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

aging

Calabrese, V. and Scapagnini, G. and Giuffrida Stella, A. M. and Bates, T. E. and Clark, J. B. (2001) Mitochondrial involvement in brain function and dysfunction: relevance to aging, neurodegenerative disorders and longevity. Neurochemical Research, 26 (6). pp. 739-64. ISSN 0364-3190

aglycemia

Brooks, K. J. and Clark, J. B. and Bates, T. E. (1996) Assessment of energy metabolism in the developing brain following aglycemic hypoxia by 1H and 31P NMR. Neurochemical Research, 21 (9). pp. 1089-1095. ISSN 0364-3190

Brooks, K. J. and Hargreaves, I. P. and Bates, T. E. (2000) Nitric-oxide-induced inhibition of mitochondrial complexes following aglycaemic hypoxia in neonatal cortical rat brain slices. Developmental Neuroscience, 22 (5-6). pp. 359-65. ISSN 0378-5866

Brooks, Keith J. and Clark, John B. and Bates, Timothy E. (1998) 3-Hydroxybutyrate aids the recovery of the energy state from aglycaemic hypoxia of adult but not neonatal rat brain slices. Journal of Neurochemistry, 70 (5). pp. 1986-1990. ISSN 0022-3042

Keelan, J. and Brand, M. P. and Bates, T. E. and Land, J. M. and Clark, J. B. and Heales, S. J. (1996) Nitric oxide and antioxidant status in glucose and oxygen deprived neonatal and adult rat brain synaptosomes. Neurochemical Research, 21 (8). pp. 923-7. ISSN 0364-3190

Keelan, Julie and Bates, Timothy E. and Clark, John B. (1996) Intrasynaptosomal free calcium concentration during rat brain development: effects of hypoxia, aglycaemia, and ischaemia. Journal of neurochemistry, 66 (6). pp. 2460-7. ISSN 0022-3042

algorithm

Bingley, P. J. and Christie, M. R. and Bonifacio, E. and Bonfanti, R. and Shattock, M. and Fonte, M.-T. and Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

allele

Gylling, Mikhail and Tuomi, Tiinamaija and Bjorses, Petra and Kontiainen, Sirkka and Partanen, Jukka and Christie, Michael R. and Knip, Mikael and Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

amino acid

Bearzatto, Massimo and Naserke, Heike and Piquer, Sandra and Koczwara, Kerstin and Lampasona, Vito and Williams, Alistair and Christie, Michael R. and Bingley, Polly J. and Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

amino terminal sequence

Desai, M.a and Cull, C.A.b and Horton, V.A.a and Christie, M.R.c and Bonifacio, E.d and Lampasona, V.d and Bingley, P.J.e and Levy, J.C.a and Mackay, I.R.f and Zimmet, P.g and Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

amyloid

Canevari, Laura and Clark, John B. and Bates, Timothy E. (1999) Beta-amyloid fragment 25-35 selectively decreases complex IV activity in isolated mitochondria. FEBS Letters, 457 (1). pp. 131-4. ISSN 0014-5793

amyloid precursor protein

Canevari, Laura and Clark, John B. and Bates, Timothy E. (1999) Beta-amyloid fragment 25-35 selectively decreases complex IV activity in isolated mitochondria. FEBS Letters, 457 (1). pp. 131-4. ISSN 0014-5793

Pardon, Marie-Christine and Sarmad, Sarir and Rattray, Ivan and Bates, Timothy E. and Scullion, Gillian A. and Marsden, Charles A. and Barrett, David A. and Lowe, James and Kendall, David A. (2009) Repeated novel cage exposure-induced improvement of early Alzheimer's-like cognitive and amyloid changes in TASTPM mice is unrelated to changes in brain endocannabinoids levels. Neurobiology of Aging, 30 (7). pp. 1099-1113. ISSN 0197-4580

anandamide

Athanasiou, Andriani and Clarke, Anna B. and Turner, Amy E. and Kumaran, Nethia M. and Vakilpour, Sara and Smith, Paul A. and Bagiokou, Dimitra and Bradshaw, Tracey D. and Westwell, Andrew D. and Fang, Lin and Lobo, Dileep N. and Constantinescu, Cris S. and Calabrese, Vittorio and Loesch, Andrzej and Alexander, Stephen P. H. and Clothier, Richard H. and Kendall, David A. and Bates, Timothy E. (2007) Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications, 364 (1). pp. 131-137. ISSN 0006-291x

animal cell

Payton, M. A. and Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

animal experiment

Piquer, Sandra and Valera, Lionel and Lampasona, Vito and Jardin-Watelet, Benedicte and Roche, Stephanie and Granier, Claude and Roquet, Francoise and Christie, Michael R. and Giordano, Tiziana and Malosio, Maria-Luisa and Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

animal model

Zhao, M. and Amiel, S. A. and Christie, Michael R. and Rela, M. and Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Zhao, M. and Christie, M.R. and Heaton, N. and George, S. and Amiel, S. and Huang, G.C. (2002) Amelioration of streptozotocin-induced diabetes in mice using human islet cells derived from long-term culture in vitro. Transplantation, 73 (9). pp. 1454-1460. ISSN 0041-1337

animal tissue

Christie, Michael and Brown, T. J. and Cassidy, D. (1992) Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme. Diabetologia, 35 (4). pp. 380-384. ISSN 0012-186X

Piquer, Sandra and Valera, Lionel and Lampasona, Vito and Jardin-Watelet, Benedicte and Roche, Stephanie and Granier, Claude and Roquet, Francoise and Christie, Michael R. and Giordano, Tiziana and Malosio, Maria-Luisa and Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

Zhao, M. and Christie, M.R. and Heaton, N. and George, S. and Amiel, S. and Huang, G.C. (2002) Amelioration of streptozotocin-induced diabetes in mice using human islet cells derived from long-term culture in vitro. Transplantation, 73 (9). pp. 1454-1460. ISSN 0041-1337

antibody

Christie, M. R. (1993) Characterization of distinct islet protein auto antigens associated with type 1 diabetes. Autoimmunity, 15 (s1). pp. 1-3. ISSN 0891-6934

antibody blood level

Christie, M. R. and Daneman, D. and Champagne, P. and Delovitch, T. L. (1990) Persistence of serum antibodies to 64,000-Mr islet cell protein after onset of type I diabetes. Diabetes, 39 (6). pp. 653-656. ISSN 0012-1797

Roll, U. and Christie, M. R. and Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

antibody detection

Bingley, P. J. and Christie, M. R. and Bonifacio, E. and Bonfanti, R. and Shattock, M. and Fonte, M.-T. and Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Christie, M. R. and Daneman, D. and Champagne, P. and Delovitch, T. L. (1990) Persistence of serum antibodies to 64,000-Mr islet cell protein after onset of type I diabetes. Diabetes, 39 (6). pp. 653-656. ISSN 0012-1797

Christie, M. R. and Genovese, S. and Cassidy, D. and Bosi, E. and Brown, T. J. and Lai, M. and Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

Christie, M. R. and Tun, R. Y. M. and Lo, S. S. S. and Cassidy, D. and Brown, T. J. and Hollands, J. and Shattock, M. and Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Christie, Michael R. and Roll, Ursula and Payton, Mark A. and Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Damanhouri, L. H. and Dromey, J. A. and Christie, Michael R. and Nasrat, H. A. and Ardawi, M. S. M. and Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Gylling, Mikhail and Tuomi, Tiinamaija and Bjorses, Petra and Kontiainen, Sirkka and Partanen, Jukka and Christie, Michael R. and Knip, Mikael and Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

Morgenthaler, N. G. and Löbner, K. and Morgenthaler, U. Y. and Christie, M. R. and Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Roll, U. and Christie, M. R. and Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

Wagner, R. and McNally, J. M. and Bonifacio, E. and Genovese, S. and Foulis, A. and McGill, M. and Christie, M. R. and Betterle, C. and Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

antibody response

Bingley, P. J. and Christie, M. R. and Bonifacio, E. and Bonfanti, R. and Shattock, M. and Fonte, M.-T. and Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Christie, M. R. and Genovese, S. and Cassidy, D. and Bosi, E. and Brown, T. J. and Lai, M. and Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

antibody specificity

Bingley, P. J. and Christie, M. R. and Bonifacio, E. and Bonfanti, R. and Shattock, M. and Fonte, M.-T. and Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Christie, M. R. and Hollands, J. A. and Brown, T. J. and Michelsen, B. K. and Delovitch, T. L. (1993) Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. Journal of Clinical Investigation, 92 (1). pp. 240-248. ISSN 0021-9738

Christie, M. R. and Tun, R. Y. M. and Lo, S. S. S. and Cassidy, D. and Brown, T. J. and Hollands, J. and Shattock, M. and Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

antibody titer

Bingley, P. J. and Christie, M. R. and Bonifacio, E. and Bonfanti, R. and Shattock, M. and Fonte, M.-T. and Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Damanhouri, L. H. and Dromey, J. A. and Christie, Michael R. and Nasrat, H. A. and Ardawi, M. S. M. and Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Roll, U. and Christie, M. R. and Fuchtenbusch, M. and Payton, M. A. and Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

antibody, autoimmunity

Bottazzo, G. F. and Genovese, S. and Bosi, E. and Dean, B. M. and Christie, M. R. and Bonifacio, E. (1991) Novel considerations on the antibody/autoantigen system in type I (insulin-dependent) diabetes mellitus. Annals of Medicine, 23 (4). pp. 453-461. ISSN 0785-3890

anticancer

Daley, E. and Wilkie, D. and Loesch, A. and Hargreaves, I. P. and Kendall, D. A. and Pilkington, G. J. and Bates, T. E. (2005) Chlorimipramine: a novel anticancer agent with a mitochondrial target. Biochemical and Biophysical Research Communications, 328 (2). pp. 623-632. ISSN 0006-291X

antidepressants

Daley, E. and Wilkie, D. and Loesch, A. and Hargreaves, I. P. and Kendall, D. A. and Pilkington, G. J. and Bates, T. E. (2005) Chlorimipramine: a novel anticancer agent with a mitochondrial target. Biochemical and Biophysical Research Communications, 328 (2). pp. 623-632. ISSN 0006-291X

antidiabetic agent

Christie, Michael R. and Molvig, Jens and Hawkes, Charlotte J. and Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

antigen

Christie, M. R. (1993) Characterization of distinct islet protein auto antigens associated with type 1 diabetes. Autoimmunity, 15 (s1). pp. 1-3. ISSN 0891-6934

Hawkes, C. J. and Wasmeier, C. and Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

antigen antibody complex

Hawkes, C. J. and Wasmeier, C. and Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

antigen antibody reaction

Desai, M.a and Cull, C.A.b and Horton, V.A.a and Christie, M.R.c and Bonifacio, E.d and Lampasona, V.d and Bingley, P.J.e and Levy, J.C.a and Mackay, I.R.f and Zimmet, P.g and Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

antigen binding

Bearzatto, Massimo and Naserke, Heike and Piquer, Sandra and Koczwara, Kerstin and Lampasona, Vito and Williams, Alistair and Christie, Michael R. and Bingley, Polly J. and Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Christie, M. R. and Hollands, J. A. and Brown, T. J. and Michelsen, B. K. and Delovitch, T. L. (1993) Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. Journal of Clinical Investigation, 92 (1). pp. 240-248. ISSN 0021-9738

Hatfield, E. C. I. and Hawkes, C. J. and Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Hawkes, C. J. and Wasmeier, C. and Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Payton, M. A. and Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Piquer, Sandra and Valera, Lionel and Lampasona, Vito and Jardin-Watelet, Benedicte and Roche, Stephanie and Granier, Claude and Roquet, Francoise and Christie, Michael R. and Giordano, Tiziana and Malosio, Maria-Luisa and Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

antigen detection

Christie, M. R. and Hollands, J. A. and Brown, T. J. and Michelsen, B. K. and Delovitch, T. L. (1993) Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. Journal of Clinical Investigation, 92 (1). pp. 240-248. ISSN 0021-9738

Roll, U. and Christie, M. R. and Fuchtenbusch, M. and Payton, M. A. and Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

antigen expression

Hawkes, C. J. and Wasmeier, C. and Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

antigen presentation

Bearzatto, Massimo and Naserke, Heike and Piquer, Sandra and Koczwara, Kerstin and Lampasona, Vito and Williams, Alistair and Christie, Michael R. and Bingley, Polly J. and Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

antigen recognition

Hatfield, E. C. I. and Hawkes, C. J. and Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

antigen specificity

Bearzatto, Massimo and Naserke, Heike and Piquer, Sandra and Koczwara, Kerstin and Lampasona, Vito and Williams, Alistair and Christie, Michael R. and Bingley, Polly J. and Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Christie, M. R. and Genovese, S. and Cassidy, D. and Bosi, E. and Brown, T. J. and Lai, M. and Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

Hawkes, C. J. and Schloot, N. C. and Marks, J. and Willemen, S. J. M. and Drijfhout, J. W. and Mayer, E. K. and Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

antisense cDNA

Levicar, Natasa and Dewey, Ricardo A. and Daley, Emma and Bates, Timothy E. and Davies, Derek and Kos, Janko and Pilkington, Geoffrey J. and Lah, Tamara T. (2003) Selective suppression of cathepsin L by antisense cDNA impairs human brain tumor cell invasion in vitro and promotes apoptosis. Cancer Gene Therapy, 10 (2). pp. 141-51. ISSN 0929-1903

apoptosis

Athanasiou, Andriani and Clarke, Anna B. and Turner, Amy E. and Kumaran, Nethia M. and Vakilpour, Sara and Smith, Paul A. and Bagiokou, Dimitra and Bradshaw, Tracey D. and Westwell, Andrew D. and Fang, Lin and Lobo, Dileep N. and Constantinescu, Cris S. and Calabrese, Vittorio and Loesch, Andrzej and Alexander, Stephen P. H. and Clothier, Richard H. and Kendall, David A. and Bates, Timothy E. (2007) Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications, 364 (1). pp. 131-137. ISSN 0006-291x

Athanasiou, Andriani and Smith, Paul A. and Vakilpour, Sara and Kumaran, Nethia M. and Turner, Amy E. and Bagiokou, Dimitra and Layfield, Robert and Ray, David E. and Westwell, Andrew D. and Alexander, Stephen P. H. and Kendall, David A. and Lobo, Dileep N. and Watson, Susan A. and Lophatanon, Artitaya and Muir, Kenneth A. and Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

Daley, E. and Wilkie, D. and Loesch, A. and Hargreaves, I. P. and Kendall, D. A. and Pilkington, G. J. and Bates, T. E. (2005) Chlorimipramine: a novel anticancer agent with a mitochondrial target. Biochemical and Biophysical Research Communications, 328 (2). pp. 623-632. ISSN 0006-291X

Levicar, Natasa and Dewey, Ricardo A. and Daley, Emma and Bates, Timothy E. and Davies, Derek and Kos, Janko and Pilkington, Geoffrey J. and Lah, Tamara T. (2003) Selective suppression of cathepsin L by antisense cDNA impairs human brain tumor cell invasion in vitro and promotes apoptosis. Cancer Gene Therapy, 10 (2). pp. 141-51. ISSN 0929-1903

arm-cranking exercise

Klonizakis, Markos (2012) Studying the cutaneous microcirculatory response during upper-limb exercise in healthy, older, sedentary people. Clinical Hemorheology and Microcirculation, 51 (1). pp. 69-75. ISSN 1386-0281

article

Bearzatto, Massimo and Naserke, Heike and Piquer, Sandra and Koczwara, Kerstin and Lampasona, Vito and Williams, Alistair and Christie, Michael R. and Bingley, Polly J. and Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Bingley, P. J. and Christie, M. R. and Bonifacio, E. and Bonfanti, R. and Shattock, M. and Fonte, M.-T. and Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Christie, M. R. and Daneman, D. and Champagne, P. and Delovitch, T. L. (1990) Persistence of serum antibodies to 64,000-Mr islet cell protein after onset of type I diabetes. Diabetes, 39 (6). pp. 653-656. ISSN 0012-1797

Christie, M. R. and Genovese, S. and Cassidy, D. and Bosi, E. and Brown, T. J. and Lai, M. and Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

Christie, M. R. and Hollands, J. A. and Brown, T. J. and Michelsen, B. K. and Delovitch, T. L. (1993) Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. Journal of Clinical Investigation, 92 (1). pp. 240-248. ISSN 0021-9738

Christie, M. R. and Tun, R. Y. M. and Lo, S. S. S. and Cassidy, D. and Brown, T. J. and Hollands, J. and Shattock, M. and Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Christie, M. R. and Vohra, G. and Champagne, P. and Daneman, D. and Delovitch, T. L. (1990) Distinct antibody specificities to a 64-kD islet cell antigen in Type 1 diabetes as revealed by trypsin treatment. Journal of Experimental Medicine, 172 (3). pp. 789-794. ISSN 0022-1007

Christie, Michael and Brown, T. J. and Cassidy, D. (1992) Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme. Diabetologia, 35 (4). pp. 380-384. ISSN 0012-186X

Christie, Michael and Landin-Olsson, M. and Sundkvist, G. and Dahlquist, G. and Lernmark, A. and Baekkeskov, S. (1988) Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes. Diabetologia, 31 (8). pp. 597-602. ISSN 0012-186X

Christie, Michael R. and Roll, Ursula and Payton, Mark A. and Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Damanhouri, L. H. and Dromey, J. A. and Christie, Michael R. and Nasrat, H. A. and Ardawi, M. S. M. and Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Desai, M.a and Cull, C.A.b and Horton, V.A.a and Christie, M.R.c and Bonifacio, E.d and Lampasona, V.d and Bingley, P.J.e and Levy, J.C.a and Mackay, I.R.f and Zimmet, P.g and Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Gillespie, Kathleen M. and Bain, Steven C. and Barnett, Anthony H. and Bingley, Polly J. and Christie, Michael R. and Gill, Geoffrey V. and Gale, Edwin A. M. (2004) The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. The Lancet, 364 (9446). pp. 1699-1700. ISSN 0140-6736

Gorus, F. K. and Goubert, P. and Semakula, C. and Vandewalle, C. L. and De Schepper, J. and Scheen, A. and Christie, Michael R. and Pipeleers, D. G. (1997) IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia, 40 (1). pp. 95-99. ISSN 0012-186X

Gylling, Mikhail and Tuomi, Tiinamaija and Bjorses, Petra and Kontiainen, Sirkka and Partanen, Jukka and Christie, Michael R. and Knip, Mikael and Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

Hatfield, E. C. I. and Hawkes, C. J. and Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Hawa, M. and Rowe, R. and Lan, M. S. and Notkins, A. L. and Pozzilli, P. and Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Hawkes, C. J. and Schloot, N. C. and Marks, J. and Willemen, S. J. M. and Drijfhout, J. W. and Mayer, E. K. and Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

Hawkes, C. J. and Wasmeier, C. and Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Huang, Guo Cai and Zhao, Min and Jones, Peter and Persaud, Shanta and Ramracheya, Reshma and Lobner, Kristian and Christie, Michael R. and Banga, J. Paul and Peakman, Mark and Sirinivsan, Parthi and Rela, Mohammed and Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Lampeter, E. F. and Kolb, H. and Seifert, I. and Lohmann, D. and Heise, J. W. and Bertrams, J. and Christie, Michael and Kolb-Bachofen, V. (1994) Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity. Diabetologia, 37 (5). pp. 471-475. ISSN 0012-186X

Morgenthaler, N. G. and Löbner, K. and Morgenthaler, U. Y. and Christie, M. R. and Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Morgenthaler, N. G. and Seissler, J. and Achenbach, P. and Glawe, D. and Payton, M. and Meinck, H.-M. and Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Payton, M. A. and Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Piquer, Sandra and Valera, Lionel and Lampasona, Vito and Jardin-Watelet, Benedicte and Roche, Stephanie and Granier, Claude and Roquet, Francoise and Christie, Michael R. and Giordano, Tiziana and Malosio, Maria-Luisa and Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

Roll, U. and Christie, M. R. and Fuchtenbusch, M. and Payton, M. A. and Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Roll, U. and Christie, M. R. and Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

Seissler, J. and Morgenthaler, N. G. and Achenbach, P. and Lampeter, E .F. and Glawe, D. and Payton, M. and Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

Wagner, R. and Genovese, S. and Bosi, E. and Becker, F. and Bingley, P. J. and Bonifacio, E. and Miles, K. A. and Christie, Michael and Bottazzo, G. F. and Gale, E. A. M. (1994) Slow metabolic deterioration towards diabetes in islet cell antibody positive patients with autoimmune polyendocrine disease. Diabetologia, 37 (4). pp. 365-371. ISSN 0012-186X

Wagner, R. and McNally, J. M. and Bonifacio, E. and Genovese, S. and Foulis, A. and McGill, M. and Christie, M. R. and Betterle, C. and Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

Winnock, Frederic and Christie, Michael R. and Batstra, Manou R. and Aanstoot, Henk-Jan and Weets, Ilse and Decochez, Katelijn and Jopart, Philippe and Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

Zhao, M. and Amiel, S. A. and Christie, Michael R. and Rela, M. and Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Zhao, M. and Christie, M.R. and Heaton, N. and George, S. and Amiel, S. and Huang, G.C. (2002) Amelioration of streptozotocin-induced diabetes in mice using human islet cells derived from long-term culture in vitro. Transplantation, 73 (9). pp. 1454-1460. ISSN 0041-1337

autoantibody

Bearzatto, Massimo and Naserke, Heike and Piquer, Sandra and Koczwara, Kerstin and Lampasona, Vito and Williams, Alistair and Christie, Michael R. and Bingley, Polly J. and Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Bingley, P. J. and Christie, M. R. and Bonifacio, E. and Bonfanti, R. and Shattock, M. and Fonte, M.-T. and Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Bonifacio, E. and Christie, M. R. (1997) Islet cell antigens in the prediction and prevention of insulin-dependent diabetes mellitus. Annals of Medicine, 29 (5). pp. 405-412. ISSN 0785-3890

Christie, M. R. and Genovese, S. and Cassidy, D. and Bosi, E. and Brown, T. J. and Lai, M. and Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

Christie, M. R. and Hollands, J. A. and Brown, T. J. and Michelsen, B. K. and Delovitch, T. L. (1993) Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. Journal of Clinical Investigation, 92 (1). pp. 240-248. ISSN 0021-9738

Christie, M. R. and Tun, R. Y. M. and Lo, S. S. S. and Cassidy, D. and Brown, T. J. and Hollands, J. and Shattock, M. and Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Christie, M. R. and Vohra, G. and Champagne, P. and Daneman, D. and Delovitch, T. L. (1990) Distinct antibody specificities to a 64-kD islet cell antigen in Type 1 diabetes as revealed by trypsin treatment. Journal of Experimental Medicine, 172 (3). pp. 789-794. ISSN 0022-1007

Christie, Michael and Landin-Olsson, M. and Sundkvist, G. and Dahlquist, G. and Lernmark, A. and Baekkeskov, S. (1988) Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes. Diabetologia, 31 (8). pp. 597-602. ISSN 0012-186X

Christie, Michael R. and Molvig, Jens and Hawkes, Charlotte J. and Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

Christie, Michael R. and Roll, Ursula and Payton, Mark A. and Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Damanhouri, L. H. and Dromey, J. A. and Christie, Michael R. and Nasrat, H. A. and Ardawi, M. S. M. and Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Gorus, F. K. and Goubert, P. and Semakula, C. and Vandewalle, C. L. and De Schepper, J. and Scheen, A. and Christie, Michael R. and Pipeleers, D. G. (1997) IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia, 40 (1). pp. 95-99. ISSN 0012-186X

Gylling, Mikhail and Tuomi, Tiinamaija and Bjorses, Petra and Kontiainen, Sirkka and Partanen, Jukka and Christie, Michael R. and Knip, Mikael and Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

Hatfield, E. C. I. and Hawkes, C. J. and Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Morgenthaler, N. G. and Löbner, K. and Morgenthaler, U. Y. and Christie, M. R. and Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Morgenthaler, N. G. and Seissler, J. and Achenbach, P. and Glawe, D. and Payton, M. and Meinck, H.-M. and Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Piquer, Sandra and Valera, Lionel and Lampasona, Vito and Jardin-Watelet, Benedicte and Roche, Stephanie and Granier, Claude and Roquet, Francoise and Christie, Michael R. and Giordano, Tiziana and Malosio, Maria-Luisa and Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

Seissler, J. and Morgenthaler, N. G. and Achenbach, P. and Lampeter, E .F. and Glawe, D. and Payton, M. and Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

Tremble, Jennifer and Morgenthaler, Nils G. and Vlug, Arjen and Powers, Alvin C. and Christie, Michael R. and Scherbaum, Werner A. and Banga, J. Paul (1997) Human B cells secreting immunoglobulin G to glutamic acid decarboxylase- 65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes. Journal of Clinical Endocrinology and Metabolism, 82 (8). pp. 2664-2670. ISSN 0021-972X

Wagner, R. and McNally, J. M. and Bonifacio, E. and Genovese, S. and Foulis, A. and McGill, M. and Christie, M. R. and Betterle, C. and Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

Winnock, Frederic and Christie, Michael R. and Batstra, Manou R. and Aanstoot, Henk-Jan and Weets, Ilse and Decochez, Katelijn and Jopart, Philippe and Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

autoantigen

Bearzatto, Massimo and Naserke, Heike and Piquer, Sandra and Koczwara, Kerstin and Lampasona, Vito and Williams, Alistair and Christie, Michael R. and Bingley, Polly J. and Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Bonifacio, E. and Christie, M. R. (1997) Islet cell antigens in the prediction and prevention of insulin-dependent diabetes mellitus. Annals of Medicine, 29 (5). pp. 405-412. ISSN 0785-3890

Bonifacio, E. and Christie, M. R. (1996) Tyrosine phosphatase-like proteins as autoantigens in insulin-dependent diabetes mellitus: the targets for 37/40k antibodies. Diabetes, Nutrition and Metabolism - Clinical and Experimental, 9 (4). pp. 183-187. ISSN 0394-3402

Christie, M. R. (1993) Characterization of distinct islet protein auto antigens associated with type 1 diabetes. Autoimmunity, 15 (s1). pp. 1-3. ISSN 0891-6934

Christie, M. R. (1996) Islet cell autoantigens in type 1 diabetes. European Journal of Clinical Investigation, 26 (10). pp. 827-838. ISSN 0014-2972

Christie, M. R. and Hollands, J. A. and Brown, T. J. and Michelsen, B. K. and Delovitch, T. L. (1993) Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. Journal of Clinical Investigation, 92 (1). pp. 240-248. ISSN 0021-9738

Christie, M. R. and Tun, R. Y. M. and Lo, S. S. S. and Cassidy, D. and Brown, T. J. and Hollands, J. and Shattock, M. and Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Christie, Michael and Landin-Olsson, M. and Sundkvist, G. and Dahlquist, G. and Lernmark, A. and Baekkeskov, S. (1988) Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes. Diabetologia, 31 (8). pp. 597-602. ISSN 0012-186X

Hatfield, E. C. I. and Hawkes, C. J. and Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Payton, M. A. and Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Piquer, Sandra and Valera, Lionel and Lampasona, Vito and Jardin-Watelet, Benedicte and Roche, Stephanie and Granier, Claude and Roquet, Francoise and Christie, Michael R. and Giordano, Tiziana and Malosio, Maria-Luisa and Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

Roll, U. and Christie, M. R. and Fuchtenbusch, M. and Payton, M. A. and Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

autoantigen, adolescent

Hawkes, C. J. and Schloot, N. C. and Marks, J. and Willemen, S. J. M. and Drijfhout, J. W. and Mayer, E. K. and Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

autoantigen, article

Christie, M. R. and Pipeleers, D. G. and Lernmark, A. and Baekkeskov, S. (1990) Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes. Journal of Biological Chemistry, 265 (1). pp. 376-381. ISSN 0021-9258

autoimmune disease

Christie, Michael and Landin-Olsson, M. and Sundkvist, G. and Dahlquist, G. and Lernmark, A. and Baekkeskov, S. (1988) Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes. Diabetologia, 31 (8). pp. 597-602. ISSN 0012-186X

Damanhouri, L. H. and Dromey, J. A. and Christie, Michael R. and Nasrat, H. A. and Ardawi, M. S. M. and Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Gylling, Mikhail and Tuomi, Tiinamaija and Bjorses, Petra and Kontiainen, Sirkka and Partanen, Jukka and Christie, Michael R. and Knip, Mikael and Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

Morgenthaler, N. G. and Löbner, K. and Morgenthaler, U. Y. and Christie, M. R. and Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

autoimmune polyendocrinopathy

Gylling, Mikhail and Tuomi, Tiinamaija and Bjorses, Petra and Kontiainen, Sirkka and Partanen, Jukka and Christie, Michael R. and Knip, Mikael and Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

autoimmunity

Baekkeskov, S. and Warnock, G. and Christie, M. and Rajotte, R.V. and Larsen, P.M. and Fey, S. (1989) Revelation of specificity of 64K autoantibodies in IDDM serums by high-resolution 2-D gel electrophoresis. Unambiguous identification of 64K target antigen. Diabetes, 38 (9). pp. 1133-1141. ISSN 0012-1797

Bonifacio, E. and Christie, M. R. (1997) Islet cell antigens in the prediction and prevention of insulin-dependent diabetes mellitus. Annals of Medicine, 29 (5). pp. 405-412. ISSN 0785-3890

Christie, M. R. and Genovese, S. and Cassidy, D. and Bosi, E. and Brown, T. J. and Lai, M. and Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

Christie, M. R. and Pipeleers, D. G. and Lernmark, A. and Baekkeskov, S. (1990) Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes. Journal of Biological Chemistry, 265 (1). pp. 376-381. ISSN 0021-9258

Christie, Michael and Brown, T. J. and Cassidy, D. (1992) Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme. Diabetologia, 35 (4). pp. 380-384. ISSN 0012-186X

Christie, Michael R. and Roll, Ursula and Payton, Mark A. and Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Hatfield, E. C. I. and Hawkes, C. J. and Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Hawa, M. and Rowe, R. and Lan, M. S. and Notkins, A. L. and Pozzilli, P. and Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Lampeter, E. F. and Kolb, H. and Seifert, I. and Lohmann, D. and Heise, J. W. and Bertrams, J. and Christie, Michael and Kolb-Bachofen, V. (1994) Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity. Diabetologia, 37 (5). pp. 471-475. ISSN 0012-186X

Roll, U. and Christie, M. R. and Fuchtenbusch, M. and Payton, M. A. and Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Seissler, J. and Morgenthaler, N. G. and Achenbach, P. and Lampeter, E .F. and Glawe, D. and Payton, M. and Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

Tremble, Jennifer and Morgenthaler, Nils G. and Vlug, Arjen and Powers, Alvin C. and Christie, Michael R. and Scherbaum, Werner A. and Banga, J. Paul (1997) Human B cells secreting immunoglobulin G to glutamic acid decarboxylase- 65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes. Journal of Clinical Endocrinology and Metabolism, 82 (8). pp. 2664-2670. ISSN 0021-972X

Wagner, R. and Genovese, S. and Bosi, E. and Becker, F. and Bingley, P. J. and Bonifacio, E. and Miles, K. A. and Christie, Michael and Bottazzo, G. F. and Gale, E. A. M. (1994) Slow metabolic deterioration towards diabetes in islet cell antibody positive patients with autoimmune polyendocrine disease. Diabetologia, 37 (4). pp. 365-371. ISSN 0012-186X

Wagner, R. and McNally, J. M. and Bonifacio, E. and Genovese, S. and Foulis, A. and McGill, M. and Christie, M. R. and Betterle, C. and Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

autoradiography

Christie, M. R. and Tun, R. Y. M. and Lo, S. S. S. and Cassidy, D. and Brown, T. J. and Hollands, J. and Shattock, M. and Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Christie, Michael and Landin-Olsson, M. and Sundkvist, G. and Dahlquist, G. and Lernmark, A. and Baekkeskov, S. (1988) Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes. Diabetologia, 31 (8). pp. 597-602. ISSN 0012-186X

b lymphocyte

Wagner, R. and McNally, J. M. and Bonifacio, E. and Genovese, S. and Foulis, A. and McGill, M. and Christie, M. R. and Betterle, C. and Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

betacellulin

Zhao, M. and Amiel, S. A. and Christie, Michael R. and Rela, M. and Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

binding affinity

Hawkes, C. J. and Wasmeier, C. and Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

biological marker

Seissler, J. and Morgenthaler, N. G. and Achenbach, P. and Lampeter, E .F. and Glawe, D. and Payton, M. and Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

Zhao, M. and Amiel, S. A. and Christie, Michael R. and Rela, M. and Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

biotin

Morgenthaler, N. G. and Löbner, K. and Morgenthaler, U. Y. and Christie, M. R. and Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

blood

Christie, Michael R. and Molvig, Jens and Hawkes, Charlotte J. and Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

Winnock, Frederic and Christie, Michael R. and Batstra, Manou R. and Aanstoot, Henk-Jan and Weets, Ilse and Decochez, Katelijn and Jopart, Philippe and Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

blood flow

Tew, Garry A. and Klonizakis, Markos and Crank, Helen and Briers, J. David and Hodges, Gary J. (2011) Comparison of laser speckle contrast imaging with laser Doppler for assessing microvascular function. Microvascular Research, 82 (3). pp. 326-332. ISSN 0026-2862

blood level

Christie, M. R. and Daneman, D. and Champagne, P. and Delovitch, T. L. (1990) Persistence of serum antibodies to 64,000-Mr islet cell protein after onset of type I diabetes. Diabetes, 39 (6). pp. 653-656. ISSN 0012-1797

blood sampling

Christie, M. R. and Tun, R. Y. M. and Lo, S. S. S. and Cassidy, D. and Brown, T. J. and Hollands, J. and Shattock, M. and Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Payton, M. A. and Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

bmjaccents

Biswas, Subhajit and Nunez Miguel, Ricardo and Sukla, Soumi and Field, Hugh J. (2009) A mutation in helicase motif IV of herpes simplex virus type 1 UL5 that results in reduced growth in vitro and lower virulence in a murine infection model is related to the predicted helicase structure. Journal of General Virology, 90 (8). pp. 1937-1942. ISSN 0022-1317

bmjanomaly

Almeida, A. and Brooks, K. J. and Sammut, I. and Keelan, J. and Davey, G. P. and Clark, J. B. and Bates, T. E. (1995) Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain. Developmental neuroscience, 17 (4). pp. 212-218. ISSN 0378-5866

bmjdoi

Brooks, K. J. and Hargreaves, I. P. and Clark, J. B. and Bates, Timothy (1998) Ischaemia-induced damage to mitochondrial complexes in the neonatal brain--role of NO. Biochemical Society Transactions, 26 (4). S343. ISSN 0300-5127

bmjgoldcheck

McLaughlin, Kerry A. and Richardson, Carolyn C. and Williams, Stefan and Bonifacio, Ezio and Morgan, Diana and Feltbower, Richard G. and Powell, Michael and Rees Smith, Bernard and Furmaniak, Jadwiga and Christie, Michael R. (2015) Relationships between major epitopes of the IA-2 autoantigen in Type 1 diabetes: implications for determinant spreading. Clinical Immunology, 160 (2). pp. 226-236. ISSN 1521-6616

Middleton, Geoff and Keegan, Richard and Smith, Mark F. and Alkhatib, Ahmed and Klonizakis, Markos (2015) Implementing a Mediterranean diet intervention into a RCT: lessons learned from a non-Mediterranean based country. Journal of Nutrition, Health and Aging, 19 (7). pp. 771-777. ISSN 1279-7707

brain

Almeida, A. and Brooks, K. J. and Sammut, I. and Keelan, J. and Davey, G. P. and Clark, J. B. and Bates, T. E. (1995) Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain. Developmental Neuroscience, 17 (4). pp. 212-218. ISSN 0378-5866

Almeida, Angeles and Allen, Kathryn L. and Bates, TImothy E. and Clark, John B. (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. Journal of neurochemistry, 65 (4). pp. 1698-1703. ISSN 0022-3042

Bates, T E and Almeida, A and Heales, S J and Clark, J B (1994) Postnatal development of the complexes of the electron transport chain in isolated rat brain mitochondria. Developmental neuroscience, 16 (5-6). pp. 321-7. ISSN 0378-5866

Brooks, K. J. and Hargreaves, I. P. and Clark, J. B. and Bates, Timothy (1998) Ischaemia-induced damage to mitochondrial complexes in the neonatal brain--role of NO. Biochemical Society Transactions, 26 (4). S343. ISSN 0300-5127

Brooks, Keith J and Hargreaves, Iain and Bhakoo, Kishore and Sellwood, Mark and O'Brien, Francis and Noone, Martina and Sakata, Yasuko and Cady, Ernest and Wylezinska, Marzena and Thornton, John and Ordidge, Roger and Nguyen, Quyen and Clemence, Matthew and Wyatt, John and Bates, Timothy E. (2002) Delayed hypothermia prevents decreases in N-acetylaspartate and reduced glutathione in the cerebral cortex of the neonatal pig following transient hypoxia-ischaemia. Neurochemical Research, 27 (12). pp. 1599-604. ISSN 0364-3190

Brooks, Keith J. and Clark, John B. and Bates, Timothy E. (1998) 3-Hydroxybutyrate aids the recovery of the energy state from aglycaemic hypoxia of adult but not neonatal rat brain slices. Journal of Neurochemistry, 70 (5). pp. 1986-1990. ISSN 0022-3042

Calabrese, V. and Bates, T. E. and Stella, A. M. (2000) NO synthase and NO-dependent signal pathways in brain aging and neurodegenerative disorders: the role of oxidant/antioxidant balance. Neurochemical Research, 25 (9-10). pp. 1315-41. ISSN 0364-3190

Calabrese, V. and Scapagnini, G. and Catalano, C. and Dinotta, F. and Bates, T. E. and Calvani, M. and Stella, A. M. (2001) Effects of acetyl-L-carnitine on the formation of fatty acid ethyl esters in brain and peripheral organs after short-term ethanol administration in rat. Neurochemical Research, 26 (2). pp. 167-74. ISSN 0364-3190

Calabrese, V. and Scapagnini, G. and Giuffrida Stella, A. M. and Bates, T. E. and Clark, J. B. (2001) Mitochondrial involvement in brain function and dysfunction: relevance to aging, neurodegenerative disorders and longevity. Neurochemical Research, 26 (6). pp. 739-64. ISSN 0364-3190

Canevari, Laura and Clark, John B. and Bates, Timothy E. (1999) Beta-amyloid fragment 25-35 selectively decreases complex IV activity in isolated mitochondria. FEBS Letters, 457 (1). pp. 131-4. ISSN 0014-5793

Christie, Michael and Brown, T. J. and Cassidy, D. (1992) Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme. Diabetologia, 35 (4). pp. 380-384. ISSN 0012-186X

Keelan, Julie and Bates, Timothy E. and Clark, John B. (1999) Heightened resistance of the neonatal brain to ischemia-reperfusion involves a lack of mitochondrial damage in the nerve terminal. Brain research, 821 (1). pp. 124-33. ISSN 0006-8993

Kristián, Tibor and Gertsch, Jeff and Bates, Timothy E. and Siesjö, Bo K. (2000) Characteristics of the calcium-triggered mitochondrial permeability transition in nonsynaptic brain mitochondria: effect of cyclosporin A and ubiquinone O. Journal of Neurochemistry, 74 (5). pp. 1999-2009. ISSN 0022-3042

Kristián, Tibor and Weatherby, Tina M. and Bates, Timothy E. and Fiskum, Gary (2002) Heterogeneity of the calcium-induced permeability transition in isolated non-synaptic brain mitochondria. Journal of Neurochemistry, 83 (6). pp. 1297-308. ISSN 0022-3042

brain enzyme

Roll, U. and Christie, M. R. and Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

brain slices

Brooks, K. J. and Clark, J. B. and Bates, T. E. (1996) Assessment of energy metabolism in the developing brain following aglycemic hypoxia by 1H and 31P NMR. Neurochemical Research, 21 (9). pp. 1089-1095. ISSN 0364-3190

Brooks, K. J. and Hargreaves, I. P. and Bates, T. E. (2000) Nitric-oxide-induced inhibition of mitochondrial complexes following aglycaemic hypoxia in neonatal cortical rat brain slices. Developmental Neuroscience, 22 (5-6). pp. 359-65. ISSN 0378-5866

Brooks, Keith J. and Clark, John B. and Bates, Timothy E. (1998) 3-Hydroxybutyrate aids the recovery of the energy state from aglycaemic hypoxia of adult but not neonatal rat brain slices. Journal of Neurochemistry, 70 (5). pp. 1986-1990. ISSN 0022-3042

c peptide

Christie, M. R. and Daneman, D. and Champagne, P. and Delovitch, T. L. (1990) Persistence of serum antibodies to 64,000-Mr islet cell protein after onset of type I diabetes. Diabetes, 39 (6). pp. 653-656. ISSN 0012-1797

calcium

Kristián, Tibor and Gertsch, Jeff and Bates, Timothy E. and Siesjö, Bo K. (2000) Characteristics of the calcium-triggered mitochondrial permeability transition in nonsynaptic brain mitochondria: effect of cyclosporin A and ubiquinone O. Journal of Neurochemistry, 74 (5). pp. 1999-2009. ISSN 0022-3042

Kristián, Tibor and Weatherby, Tina M. and Bates, Timothy E. and Fiskum, Gary (2002) Heterogeneity of the calcium-induced permeability transition in isolated non-synaptic brain mitochondria. Journal of Neurochemistry, 83 (6). pp. 1297-308. ISSN 0022-3042

cancer

Athanasiou, Andriani and Smith, Paul A. and Vakilpour, Sara and Kumaran, Nethia M. and Turner, Amy E. and Bagiokou, Dimitra and Layfield, Robert and Ray, David E. and Westwell, Andrew D. and Alexander, Stephen P. H. and Kendall, David A. and Lobo, Dileep N. and Watson, Susan A. and Lophatanon, Artitaya and Muir, Kenneth A. and Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

Dagnelie, P. C. and Bell, J. D. and Williams, S. C. and Bates, T. E. and Abel, P. D. and Foster, C. S. (1993) Altered phosphorylation status, phospholipid metabolism and gluconeogenesis in the host liver of rats with prostate cancer: a 31P magnetic resonance spectroscopy study. British Journal of Cancer, 67 (6). pp. 1303-1309. ISSN 0007-0920

Daley, E. and Wilkie, D. and Loesch, A. and Hargreaves, I. P. and Kendall, D. A. and Pilkington, G. J. and Bates, T. E. (2005) Chlorimipramine: a novel anticancer agent with a mitochondrial target. Biochemical and Biophysical Research Communications, 328 (2). pp. 623-632. ISSN 0006-291X

candidiasis

Gylling, Mikhail and Tuomi, Tiinamaija and Bjorses, Petra and Kontiainen, Sirkka and Partanen, Jukka and Christie, Michael R. and Knip, Mikael and Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

cannabinoid

Athanasiou, Andriani and Clarke, Anna B. and Turner, Amy E. and Kumaran, Nethia M. and Vakilpour, Sara and Smith, Paul A. and Bagiokou, Dimitra and Bradshaw, Tracey D. and Westwell, Andrew D. and Fang, Lin and Lobo, Dileep N. and Constantinescu, Cris S. and Calabrese, Vittorio and Loesch, Andrzej and Alexander, Stephen P. H. and Clothier, Richard H. and Kendall, David A. and Bates, Timothy E. (2007) Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications, 364 (1). pp. 131-137. ISSN 0006-291x

capsazepine

Athanasiou, Andriani and Smith, Paul A. and Vakilpour, Sara and Kumaran, Nethia M. and Turner, Amy E. and Bagiokou, Dimitra and Layfield, Robert and Ray, David E. and Westwell, Andrew D. and Alexander, Stephen P. H. and Kendall, David A. and Lobo, Dileep N. and Watson, Susan A. and Lophatanon, Artitaya and Muir, Kenneth A. and Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

carboxy terminal sequence

Desai, M.a and Cull, C.A.b and Horton, V.A.a and Christie, M.R.c and Bonifacio, E.d and Lampasona, V.d and Bingley, P.J.e and Levy, J.C.a and Mackay, I.R.f and Zimmet, P.g and Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

cardiac

Sammut, Ivan A. and Jayakumar, Jay and Latif, Najmi and Rothery, Stephen and Severs, Nicholas J. and Smolenski, Ryszard T. and Bates, Timothy E. and Yacoub, Magdi H. (2001) Heat stress contributes to the enhancement of cardiac mitochondrial complex activity. The American Journal of Pathology, 158 (5). pp. 1821-31. ISSN 0002-9440

cell culture

Zhao, M. and Amiel, S. A. and Christie, Michael R. and Rela, M. and Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

cell damage

Wagner, R. and McNally, J. M. and Bonifacio, E. and Genovese, S. and Foulis, A. and McGill, M. and Christie, M. R. and Betterle, C. and Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

cell differentiation

Zhao, M. and Amiel, S. A. and Christie, Michael R. and Rela, M. and Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Zhao, M. and Christie, M.R. and Heaton, N. and George, S. and Amiel, S. and Huang, G.C. (2002) Amelioration of streptozotocin-induced diabetes in mice using human islet cells derived from long-term culture in vitro. Transplantation, 73 (9). pp. 1454-1460. ISSN 0041-1337

cell fractionation

Zhao, M. and Amiel, S. A. and Christie, Michael R. and Rela, M. and Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

cell growth

Zhao, M. and Amiel, S. A. and Christie, Michael R. and Rela, M. and Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

cell invasion

Levicar, Natasa and Dewey, Ricardo A. and Daley, Emma and Bates, Timothy E. and Davies, Derek and Kos, Janko and Pilkington, Geoffrey J. and Lah, Tamara T. (2003) Selective suppression of cathepsin L by antisense cDNA impairs human brain tumor cell invasion in vitro and promotes apoptosis. Cancer Gene Therapy, 10 (2). pp. 141-51. ISSN 0929-1903

cell isolation

Huang, Guo Cai and Zhao, Min and Jones, Peter and Persaud, Shanta and Ramracheya, Reshma and Lobner, Kristian and Christie, Michael R. and Banga, J. Paul and Peakman, Mark and Sirinivsan, Parthi and Rela, Mohammed and Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Zhao, M. and Amiel, S. A. and Christie, Michael R. and Rela, M. and Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

cell line

Payton, M. A. and Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

cell proliferation

Zhao, M. and Christie, M.R. and Heaton, N. and George, S. and Amiel, S. and Huang, G.C. (2002) Amelioration of streptozotocin-induced diabetes in mice using human islet cells derived from long-term culture in vitro. Transplantation, 73 (9). pp. 1454-1460. ISSN 0041-1337

cell protein

Christie, M. R. and Daneman, D. and Champagne, P. and Delovitch, T. L. (1990) Persistence of serum antibodies to 64,000-Mr islet cell protein after onset of type I diabetes. Diabetes, 39 (6). pp. 653-656. ISSN 0012-1797

Christie, M. R. and Tun, R. Y. M. and Lo, S. S. S. and Cassidy, D. and Brown, T. J. and Hollands, J. and Shattock, M. and Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

cell survival

Zhao, M. and Christie, M.R. and Heaton, N. and George, S. and Amiel, S. and Huang, G.C. (2002) Amelioration of streptozotocin-induced diabetes in mice using human islet cells derived from long-term culture in vitro. Transplantation, 73 (9). pp. 1454-1460. ISSN 0041-1337

cell viability

Huang, Guo Cai and Zhao, Min and Jones, Peter and Persaud, Shanta and Ramracheya, Reshma and Lobner, Kristian and Christie, Michael R. and Banga, J. Paul and Peakman, Mark and Sirinivsan, Parthi and Rela, Mohammed and Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

cellular distribution

Christie, M. R. and Pipeleers, D. G. and Lernmark, A. and Baekkeskov, S. (1990) Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes. Journal of Biological Chemistry, 265 (1). pp. 376-381. ISSN 0021-9258

cellular stress

Calabrese, Vittorio and Bates, Timothy E. and Mancuso, Cesare and Cornelius, Carolin and Ventimiglia, Bernardo and Cambria, Maria Teresa and Di Renzo, Laura and De Lorenzo, Antonino and Dinkova-Kostova, Albena T. (2008) Curcumin and the cellular stress response in free radical-related diseases. Molecular Nutrition & Food Research, 52 (9). pp. 1062-1073. ISSN 1613-4125

cerebral ischaemia

Almeida, Angeles and Allen, Kathryn L. and Bates, TImothy E. and Clark, John B. (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. Journal of neurochemistry, 65 (4). pp. 1698-1703. ISSN 0022-3042

cerebral ischemia

Almeida, Angeles and Allen, Kathryn L. and Bates, TImothy E. and Clark, John B. (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. Journal of neurochemistry, 65 (4). pp. 1698-1703. ISSN 0022-3042

Brooks, Keith J and Hargreaves, Iain and Bhakoo, Kishore and Sellwood, Mark and O'Brien, Francis and Noone, Martina and Sakata, Yasuko and Cady, Ernest and Wylezinska, Marzena and Thornton, John and Ordidge, Roger and Nguyen, Quyen and Clemence, Matthew and Wyatt, John and Bates, Timothy E. (2002) Delayed hypothermia prevents decreases in N-acetylaspartate and reduced glutathione in the cerebral cortex of the neonatal pig following transient hypoxia-ischaemia. Neurochemical Research, 27 (12). pp. 1599-604. ISSN 0364-3190

Canevari, Laura and Console, Antonella and Tendi, E. A. and Clark, J. B. and Bates, Timothy (1999) Effect of postischaemic hypothermia on the mitochondrial damage induced by ischaemia and reperfusion in the gerbil. Brain research, 817 (1-2). pp. 241-245. ISSN 0006-8993

cerebroprotection

Canevari, Laura and Console, Antonella and Tendi, E. A. and Clark, J. B. and Bates, Timothy (1999) Effect of postischaemic hypothermia on the mitochondrial damage induced by ischaemia and reperfusion in the gerbil. Brain research, 817 (1-2). pp. 241-245. ISSN 0006-8993

child

Bearzatto, Massimo and Naserke, Heike and Piquer, Sandra and Koczwara, Kerstin and Lampasona, Vito and Williams, Alistair and Christie, Michael R. and Bingley, Polly J. and Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Bingley, P. J. and Christie, M. R. and Bonifacio, E. and Bonfanti, R. and Shattock, M. and Fonte, M.-T. and Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Christie, Michael and Brown, T. J. and Cassidy, D. (1992) Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme. Diabetologia, 35 (4). pp. 380-384. ISSN 0012-186X

Christie, Michael and Landin-Olsson, M. and Sundkvist, G. and Dahlquist, G. and Lernmark, A. and Baekkeskov, S. (1988) Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes. Diabetologia, 31 (8). pp. 597-602. ISSN 0012-186X

Christie, Michael R. and Roll, Ursula and Payton, Mark A. and Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Gorus, F. K. and Goubert, P. and Semakula, C. and Vandewalle, C. L. and De Schepper, J. and Scheen, A. and Christie, Michael R. and Pipeleers, D. G. (1997) IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia, 40 (1). pp. 95-99. ISSN 0012-186X

Gylling, Mikhail and Tuomi, Tiinamaija and Bjorses, Petra and Kontiainen, Sirkka and Partanen, Jukka and Christie, Michael R. and Knip, Mikael and Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

Hatfield, E. C. I. and Hawkes, C. J. and Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Hawa, M. and Rowe, R. and Lan, M. S. and Notkins, A. L. and Pozzilli, P. and Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Hawkes, C. J. and Schloot, N. C. and Marks, J. and Willemen, S. J. M. and Drijfhout, J. W. and Mayer, E. K. and Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

Morgenthaler, N. G. and Löbner, K. and Morgenthaler, U. Y. and Christie, M. R. and Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Roll, U. and Christie, M. R. and Fuchtenbusch, M. and Payton, M. A. and Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Roll, U. and Christie, M. R. and Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

Seissler, J. and Morgenthaler, N. G. and Achenbach, P. and Lampeter, E .F. and Glawe, D. and Payton, M. and Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

Winnock, Frederic and Christie, Michael R. and Batstra, Manou R. and Aanstoot, Henk-Jan and Weets, Ilse and Decochez, Katelijn and Jopart, Philippe and Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

childhood disease

Gillespie, Kathleen M. and Bain, Steven C. and Barnett, Anthony H. and Bingley, Polly J. and Christie, Michael R. and Gill, Geoffrey V. and Gale, Edwin A. M. (2004) The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. The Lancet, 364 (9446). pp. 1699-1700. ISSN 0140-6736

chimera

Tremble, Jennifer and Morgenthaler, Nils G. and Vlug, Arjen and Powers, Alvin C. and Christie, Michael R. and Scherbaum, Werner A. and Banga, J. Paul (1997) Human B cells secreting immunoglobulin G to glutamic acid decarboxylase- 65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes. Journal of Clinical Endocrinology and Metabolism, 82 (8). pp. 2664-2670. ISSN 0021-972X

chlorimipramine

Daley, E. and Wilkie, D. and Loesch, A. and Hargreaves, I. P. and Kendall, D. A. and Pilkington, G. J. and Bates, T. E. (2005) Chlorimipramine: a novel anticancer agent with a mitochondrial target. Biochemical and Biophysical Research Communications, 328 (2). pp. 623-632. ISSN 0006-291X

clinical article

Bearzatto, Massimo and Naserke, Heike and Piquer, Sandra and Koczwara, Kerstin and Lampasona, Vito and Williams, Alistair and Christie, Michael R. and Bingley, Polly J. and Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Christie, M. R. and Daneman, D. and Champagne, P. and Delovitch, T. L. (1990) Persistence of serum antibodies to 64,000-Mr islet cell protein after onset of type I diabetes. Diabetes, 39 (6). pp. 653-656. ISSN 0012-1797

Christie, M. R. and Genovese, S. and Cassidy, D. and Bosi, E. and Brown, T. J. and Lai, M. and Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

Christie, M. R. and Vohra, G. and Champagne, P. and Daneman, D. and Delovitch, T. L. (1990) Distinct antibody specificities to a 64-kD islet cell antigen in Type 1 diabetes as revealed by trypsin treatment. Journal of Experimental Medicine, 172 (3). pp. 789-794. ISSN 0022-1007

Christie, Michael and Landin-Olsson, M. and Sundkvist, G. and Dahlquist, G. and Lernmark, A. and Baekkeskov, S. (1988) Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes. Diabetologia, 31 (8). pp. 597-602. ISSN 0012-186X

Hawkes, C. J. and Schloot, N. C. and Marks, J. and Willemen, S. J. M. and Drijfhout, J. W. and Mayer, E. K. and Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

Hawkes, C. J. and Wasmeier, C. and Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Huang, Guo Cai and Zhao, Min and Jones, Peter and Persaud, Shanta and Ramracheya, Reshma and Lobner, Kristian and Christie, Michael R. and Banga, J. Paul and Peakman, Mark and Sirinivsan, Parthi and Rela, Mohammed and Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Wagner, R. and Genovese, S. and Bosi, E. and Becker, F. and Bingley, P. J. and Bonifacio, E. and Miles, K. A. and Christie, Michael and Bottazzo, G. F. and Gale, E. A. M. (1994) Slow metabolic deterioration towards diabetes in islet cell antibody positive patients with autoimmune polyendocrine disease. Diabetologia, 37 (4). pp. 365-371. ISSN 0012-186X

clinical trial

Bingley, P. J. and Christie, M. R. and Bonifacio, E. and Bonfanti, R. and Shattock, M. and Fonte, M.-T. and Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Christie, Michael R. and Molvig, Jens and Hawkes, Charlotte J. and Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

Desai, M.a and Cull, C.A.b and Horton, V.A.a and Christie, M.R.c and Bonifacio, E.d and Lampasona, V.d and Bingley, P.J.e and Levy, J.C.a and Mackay, I.R.f and Zimmet, P.g and Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Gylling, Mikhail and Tuomi, Tiinamaija and Bjorses, Petra and Kontiainen, Sirkka and Partanen, Jukka and Christie, Michael R. and Knip, Mikael and Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

Roll, U. and Christie, M. R. and Fuchtenbusch, M. and Payton, M. A. and Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

clomipramine

Daley, E. and Wilkie, D. and Loesch, A. and Hargreaves, I. P. and Kendall, D. A. and Pilkington, G. J. and Bates, T. E. (2005) Chlorimipramine: a novel anticancer agent with a mitochondrial target. Biochemical and Biophysical Research Communications, 328 (2). pp. 623-632. ISSN 0006-291X

cohort analysis

Gillespie, Kathleen M. and Bain, Steven C. and Barnett, Anthony H. and Bingley, Polly J. and Christie, Michael R. and Gill, Geoffrey V. and Gale, Edwin A. M. (2004) The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. The Lancet, 364 (9446). pp. 1699-1700. ISSN 0140-6736

comparative study

Christie, Michael R. and Molvig, Jens and Hawkes, Charlotte J. and Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

Seissler, J. and Morgenthaler, N. G. and Achenbach, P. and Lampeter, E .F. and Glawe, D. and Payton, M. and Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

Winnock, Frederic and Christie, Michael R. and Batstra, Manou R. and Aanstoot, Henk-Jan and Weets, Ilse and Decochez, Katelijn and Jopart, Philippe and Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

complementary dna

Payton, M. A. and Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

complexexs

Almeida, Angeles and Allen, Kathryn L. and Bates, TImothy E. and Clark, John B. (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. Journal of neurochemistry, 65 (4). pp. 1698-1703. ISSN 0022-3042

conference paper

Christie, M. R. (1993) Characterization of distinct islet protein auto antigens associated with type 1 diabetes. Autoimmunity, 15 (s1). pp. 1-3. ISSN 0891-6934

controlled clinical trial

Bingley, P. J. and Christie, M. R. and Bonifacio, E. and Bonfanti, R. and Shattock, M. and Fonte, M.-T. and Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Christie, Michael R. and Molvig, Jens and Hawkes, Charlotte J. and Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

Desai, M.a and Cull, C.A.b and Horton, V.A.a and Christie, M.R.c and Bonifacio, E.d and Lampasona, V.d and Bingley, P.J.e and Levy, J.C.a and Mackay, I.R.f and Zimmet, P.g and Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Roll, U. and Christie, M. R. and Fuchtenbusch, M. and Payton, M. A. and Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

controlled study

Baekkeskov, S. and Warnock, G. and Christie, M. and Rajotte, R.V. and Larsen, P.M. and Fey, S. (1989) Revelation of specificity of 64K autoantibodies in IDDM serums by high-resolution 2-D gel electrophoresis. Unambiguous identification of 64K target antigen. Diabetes, 38 (9). pp. 1133-1141. ISSN 0012-1797

Bingley, P. J. and Christie, M. R. and Bonifacio, E. and Bonfanti, R. and Shattock, M. and Fonte, M.-T. and Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Christie, M. R. and Hollands, J. A. and Brown, T. J. and Michelsen, B. K. and Delovitch, T. L. (1993) Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. Journal of Clinical Investigation, 92 (1). pp. 240-248. ISSN 0021-9738

Christie, M. R. and Tun, R. Y. M. and Lo, S. S. S. and Cassidy, D. and Brown, T. J. and Hollands, J. and Shattock, M. and Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Christie, Michael and Brown, T. J. and Cassidy, D. (1992) Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme. Diabetologia, 35 (4). pp. 380-384. ISSN 0012-186X

Christie, Michael and Landin-Olsson, M. and Sundkvist, G. and Dahlquist, G. and Lernmark, A. and Baekkeskov, S. (1988) Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes. Diabetologia, 31 (8). pp. 597-602. ISSN 0012-186X

Christie, Michael R. and Molvig, Jens and Hawkes, Charlotte J. and Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

Desai, M.a and Cull, C.A.b and Horton, V.A.a and Christie, M.R.c and Bonifacio, E.d and Lampasona, V.d and Bingley, P.J.e and Levy, J.C.a and Mackay, I.R.f and Zimmet, P.g and Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Gillespie, Kathleen M. and Bain, Steven C. and Barnett, Anthony H. and Bingley, Polly J. and Christie, Michael R. and Gill, Geoffrey V. and Gale, Edwin A. M. (2004) The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. The Lancet, 364 (9446). pp. 1699-1700. ISSN 0140-6736

Gorus, F. K. and Goubert, P. and Semakula, C. and Vandewalle, C. L. and De Schepper, J. and Scheen, A. and Christie, Michael R. and Pipeleers, D. G. (1997) IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia, 40 (1). pp. 95-99. ISSN 0012-186X

Gylling, Mikhail and Tuomi, Tiinamaija and Bjorses, Petra and Kontiainen, Sirkka and Partanen, Jukka and Christie, Michael R. and Knip, Mikael and Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

Hatfield, E. C. I. and Hawkes, C. J. and Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Hawa, M. and Rowe, R. and Lan, M. S. and Notkins, A. L. and Pozzilli, P. and Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Hawkes, C. J. and Schloot, N. C. and Marks, J. and Willemen, S. J. M. and Drijfhout, J. W. and Mayer, E. K. and Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

Huang, Guo Cai and Zhao, Min and Jones, Peter and Persaud, Shanta and Ramracheya, Reshma and Lobner, Kristian and Christie, Michael R. and Banga, J. Paul and Peakman, Mark and Sirinivsan, Parthi and Rela, Mohammed and Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Lampeter, E. F. and Kolb, H. and Seifert, I. and Lohmann, D. and Heise, J. W. and Bertrams, J. and Christie, Michael and Kolb-Bachofen, V. (1994) Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity. Diabetologia, 37 (5). pp. 471-475. ISSN 0012-186X

Morgenthaler, N. G. and Löbner, K. and Morgenthaler, U. Y. and Christie, M. R. and Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Payton, M. A. and Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Piquer, Sandra and Valera, Lionel and Lampasona, Vito and Jardin-Watelet, Benedicte and Roche, Stephanie and Granier, Claude and Roquet, Francoise and Christie, Michael R. and Giordano, Tiziana and Malosio, Maria-Luisa and Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

Roll, U. and Christie, M. R. and Fuchtenbusch, M. and Payton, M. A. and Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Roll, U. and Christie, M. R. and Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

Seissler, J. and Morgenthaler, N. G. and Achenbach, P. and Lampeter, E .F. and Glawe, D. and Payton, M. and Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

Zhao, M. and Amiel, S. A. and Christie, Michael R. and Rela, M. and Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Zhao, M. and Christie, M.R. and Heaton, N. and George, S. and Amiel, S. and Huang, G.C. (2002) Amelioration of streptozotocin-induced diabetes in mice using human islet cells derived from long-term culture in vitro. Transplantation, 73 (9). pp. 1454-1460. ISSN 0041-1337

cross reaction

Hatfield, E. C. I. and Hawkes, C. J. and Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

curcumin

Calabrese, Vittorio and Bates, Timothy E. and Mancuso, Cesare and Cornelius, Carolin and Ventimiglia, Bernardo and Cambria, Maria Teresa and Di Renzo, Laura and De Lorenzo, Antonino and Dinkova-Kostova, Albena T. (2008) Curcumin and the cellular stress response in free radical-related diseases. Molecular Nutrition & Food Research, 52 (9). pp. 1062-1073. ISSN 1613-4125

Mancuso, Cesare and Bates, Timothy E. and Butterfield, D. Allan and Calafato, Stella and Cornelius, Carolin and De Lorenzo, Antonino and Dinkova Kostova, Albena T. and Calabrese, Vittorio (2007) Natural antioxidants in Alzheimer's disease. Expert Opinion on Investigational Drugs, 16 (12). pp. 1921-1931. ISSN 1354-3784

cutaneous microcirculation

Klonizakis, Markos (2012) Studying the cutaneous microcirculatory response during upper-limb exercise in healthy, older, sedentary people. Clinical Hemorheology and Microcirculation, 51 (1). pp. 69-75. ISSN 1386-0281

cyclosporin

Christie, Michael R. and Molvig, Jens and Hawkes, Charlotte J. and Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

cytochemistry

Hansen, W.A. and Christie, M.R. and Kahn, R. and Norgaard, A. and Abel, I. and Petersen, A.M. and Jorgensen, D.W. and Baekkeskov, S. and Nielsen, J.H. and Lernmark, A. and Egeberg, J. and Richter-Olesen, H. and Grainger, T. and Kristensen, J.K. and Brynitz, S. and Bilde, T. (1989) Supravital dithizone staining in the isolation of human and rat pancreatic islets. Diabetes Research, 10 (2). pp. 53-57. ISSN 0265-5985

cytochrome oxidase

Cooper, Chris E. and Davies, Nathan A. and Psychoulis, Minas and Canevari, Laura and Bates, Tim E. and Dobbie, Michael S. and Casley, Christopher S. and Sharpe, Martyn A. (2003) Nitric oxide and peroxynitrite cause irreversible increases in the K(m) for oxygen of mitochondrial cytochrome oxidase: in vitro and in vivo studies. Biochimica et Biophysica Acta: general subjects, 1607 (1). pp. 27-34. ISSN 0006-3002

cytokeratin

Zhao, M. and Amiel, S. A. and Christie, Michael R. and Rela, M. and Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

cytoplasm

Christie, Michael and Landin-Olsson, M. and Sundkvist, G. and Dahlquist, G. and Lernmark, A. and Baekkeskov, S. (1988) Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes. Diabetologia, 31 (8). pp. 597-602. ISSN 0012-186X

densitometry

Christie, M. R. and Tun, R. Y. M. and Lo, S. S. S. and Cassidy, D. and Brown, T. J. and Hollands, J. and Shattock, M. and Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

density gradient

Huang, Guo Cai and Zhao, Min and Jones, Peter and Persaud, Shanta and Ramracheya, Reshma and Lobner, Kristian and Christie, Michael R. and Banga, J. Paul and Peakman, Mark and Sirinivsan, Parthi and Rela, Mohammed and Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

development

Almeida, A. and Brooks, K. J. and Sammut, I. and Keelan, J. and Davey, G. P. and Clark, J. B. and Bates, T. E. (1995) Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain. Developmental Neuroscience, 17 (4). pp. 212-218. ISSN 0378-5866

Bates, T E and Almeida, A and Heales, S J and Clark, J B (1994) Postnatal development of the complexes of the electron transport chain in isolated rat brain mitochondria. Developmental neuroscience, 16 (5-6). pp. 321-7. ISSN 0378-5866

diabetes Education competencies

Walsh, Nicki (2011) The current status of diabetes professional educational standards and competencies in the UK: a position statement from the Diabetes UK Healthcare Professional Education Competency Framework Task and Finish Group. Diabetic Medicine, 28 (12). pp. 1501-1507. ISSN 0742-3071

diabetes mellitus

Bearzatto, Massimo and Naserke, Heike and Piquer, Sandra and Koczwara, Kerstin and Lampasona, Vito and Williams, Alistair and Christie, Michael R. and Bingley, Polly J. and Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Huang, Guo Cai and Zhao, Min and Jones, Peter and Persaud, Shanta and Ramracheya, Reshma and Lobner, Kristian and Christie, Michael R. and Banga, J. Paul and Peakman, Mark and Sirinivsan, Parthi and Rela, Mohammed and Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Wagner, R. and Genovese, S. and Bosi, E. and Becker, F. and Bingley, P. J. and Bonifacio, E. and Miles, K. A. and Christie, Michael and Bottazzo, G. F. and Gale, E. A. M. (1994) Slow metabolic deterioration towards diabetes in islet cell antibody positive patients with autoimmune polyendocrine disease. Diabetologia, 37 (4). pp. 365-371. ISSN 0012-186X

diagnosis

Bottazzo, G. F. and Genovese, S. and Bosi, E. and Dean, B. M. and Christie, M. R. and Bonifacio, E. (1991) Novel considerations on the antibody/autoantigen system in type I (insulin-dependent) diabetes mellitus. Annals of Medicine, 23 (4). pp. 453-461. ISSN 0785-3890

diagnostic value

Christie, Michael R. and Roll, Ursula and Payton, Mark A. and Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Gylling, Mikhail and Tuomi, Tiinamaija and Bjorses, Petra and Kontiainen, Sirkka and Partanen, Jukka and Christie, Michael R. and Knip, Mikael and Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

disease association

Desai, M.a and Cull, C.A.b and Horton, V.A.a and Christie, M.R.c and Bonifacio, E.d and Lampasona, V.d and Bingley, P.J.e and Levy, J.C.a and Mackay, I.R.f and Zimmet, P.g and Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Roll, U. and Christie, M. R. and Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

disease course

Christie, M. R. (1993) Characterization of distinct islet protein auto antigens associated with type 1 diabetes. Autoimmunity, 15 (s1). pp. 1-3. ISSN 0891-6934

Desai, M.a and Cull, C.A.b and Horton, V.A.a and Christie, M.R.c and Bonifacio, E.d and Lampasona, V.d and Bingley, P.J.e and Levy, J.C.a and Mackay, I.R.f and Zimmet, P.g and Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

disease duration

Damanhouri, L. H. and Dromey, J. A. and Christie, Michael R. and Nasrat, H. A. and Ardawi, M. S. M. and Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

disease marker

Damanhouri, L. H. and Dromey, J. A. and Christie, Michael R. and Nasrat, H. A. and Ardawi, M. S. M. and Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

disease predisposition

Bonifacio, E. and Christie, M. R. (1997) Islet cell antigens in the prediction and prevention of insulin-dependent diabetes mellitus. Annals of Medicine, 29 (5). pp. 405-412. ISSN 0785-3890

Hawkes, C. J. and Schloot, N. C. and Marks, J. and Willemen, S. J. M. and Drijfhout, J. W. and Mayer, E. K. and Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

dithizone, animal cell

Hansen, W.A. and Christie, M.R. and Kahn, R. and Norgaard, A. and Abel, I. and Petersen, A.M. and Jorgensen, D.W. and Baekkeskov, S. and Nielsen, J.H. and Lernmark, A. and Egeberg, J. and Richter-Olesen, H. and Grainger, T. and Kristensen, J.K. and Brynitz, S. and Bilde, T. (1989) Supravital dithizone staining in the isolation of human and rat pancreatic islets. Diabetes Research, 10 (2). pp. 53-57. ISSN 0265-5985

dizygotic twins

Hawa, M. and Rowe, R. and Lan, M. S. and Notkins, A. L. and Pozzilli, P. and Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

dopamine

Rosin, Claudia and Colombo, Sergio and Calver, Andrew A. and Bates, Timothy E. and Skaper, Stephen D. (2005) Dopamine D2 and D3 receptor agonists limit oligodendrocyte injury caused by glutamate oxidative stress and oxygen/glucose deprivation. Glia, 52 (4). pp. 336-343. ISSN 0894-1491

dopamine receptor

Rosin, Claudia and Colombo, Sergio and Calver, Andrew A. and Bates, Timothy E. and Skaper, Stephen D. (2005) Dopamine D2 and D3 receptor agonists limit oligodendrocyte injury caused by glutamate oxidative stress and oxygen/glucose deprivation. Glia, 52 (4). pp. 336-343. ISSN 0894-1491

dysfunction

Calabrese, V. and Scapagnini, G. and Giuffrida Stella, A. M. and Bates, T. E. and Clark, J. B. (2001) Mitochondrial involvement in brain function and dysfunction: relevance to aging, neurodegenerative disorders and longevity. Neurochemical Research, 26 (6). pp. 739-64. ISSN 0364-3190

eNOS

Bates, T. E. and Loesch, A. and Burnstock, G. and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochemical and biophysical research communications, 218 (1). pp. 40-44. ISSN 0006-291X

ectodermal dysplasia

Gylling, Mikhail and Tuomi, Tiinamaija and Bjorses, Petra and Kontiainen, Sirkka and Partanen, Jukka and Christie, Michael R. and Knip, Mikael and Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

electron transport chain

Bates, T E and Almeida, A and Heales, S J and Clark, J B (1994) Postnatal development of the complexes of the electron transport chain in isolated rat brain mitochondria. Developmental neuroscience, 16 (5-6). pp. 321-7. ISSN 0378-5866

electrophoresis

Baekkeskov, S. and Warnock, G. and Christie, M. and Rajotte, R.V. and Larsen, P.M. and Fey, S. (1989) Revelation of specificity of 64K autoantibodies in IDDM serums by high-resolution 2-D gel electrophoresis. Unambiguous identification of 64K target antigen. Diabetes, 38 (9). pp. 1133-1141. ISSN 0012-1797

endocannabinoid

Pardon, Marie-Christine and Sarmad, Sarir and Rattray, Ivan and Bates, Timothy E. and Scullion, Gillian A. and Marsden, Charles A. and Barrett, David A. and Lowe, James and Kendall, David A. (2009) Repeated novel cage exposure-induced improvement of early Alzheimer's-like cognitive and amyloid changes in TASTPM mice is unrelated to changes in brain endocannabinoids levels. Neurobiology of Aging, 30 (7). pp. 1099-1113. ISSN 0197-4580

endocrine disease

Christie, M. R. and Genovese, S. and Cassidy, D. and Bosi, E. and Brown, T. J. and Lai, M. and Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

Morgenthaler, N. G. and Seissler, J. and Achenbach, P. and Glawe, D. and Payton, M. and Meinck, H.-M. and Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

enzyme activity

Christie, M. R. and Tun, R. Y. M. and Lo, S. S. S. and Cassidy, D. and Brown, T. J. and Hollands, J. and Shattock, M. and Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Desai, M.a and Cull, C.A.b and Horton, V.A.a and Christie, M.R.c and Bonifacio, E.d and Lampasona, V.d and Bingley, P.J.e and Levy, J.C.a and Mackay, I.R.f and Zimmet, P.g and Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Hawkes, C. J. and Wasmeier, C. and Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

enzyme antibody

Bonifacio, E. and Christie, M. R. (1997) Islet cell antigens in the prediction and prevention of insulin-dependent diabetes mellitus. Annals of Medicine, 29 (5). pp. 405-412. ISSN 0785-3890

Christie, M. R. and Tun, R. Y. M. and Lo, S. S. S. and Cassidy, D. and Brown, T. J. and Hollands, J. and Shattock, M. and Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Hawa, M. and Rowe, R. and Lan, M. S. and Notkins, A. L. and Pozzilli, P. and Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Morgenthaler, N. G. and Seissler, J. and Achenbach, P. and Glawe, D. and Payton, M. and Meinck, H.-M. and Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Roll, U. and Christie, M. R. and Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

enzymes

Bates, T E and Almeida, A and Heales, S J and Clark, J B (1994) Postnatal development of the complexes of the electron transport chain in isolated rat brain mitochondria. Developmental neuroscience, 16 (5-6). pp. 321-7. ISSN 0378-5866

Bates, Timothy E. and Strangward, Maria and Keelan, Julia and Davey, Gavin P. and Munro, Peter M. G. and Clark, John B. (1996) Inhibition of N-acetylaspartate production: implications for 1H MRS studies in vivo. Neuroreport, 7 (8). pp. 1397-1400. ISSN 0959-4965

epitope

Bearzatto, Massimo and Naserke, Heike and Piquer, Sandra and Koczwara, Kerstin and Lampasona, Vito and Williams, Alistair and Christie, Michael R. and Bingley, Polly J. and Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Desai, M.a and Cull, C.A.b and Horton, V.A.a and Christie, M.R.c and Bonifacio, E.d and Lampasona, V.d and Bingley, P.J.e and Levy, J.C.a and Mackay, I.R.f and Zimmet, P.g and Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Hatfield, E. C. I. and Hawkes, C. J. and Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Payton, M. A. and Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Tremble, Jennifer and Morgenthaler, Nils G. and Vlug, Arjen and Powers, Alvin C. and Christie, Michael R. and Scherbaum, Werner A. and Banga, J. Paul (1997) Human B cells secreting immunoglobulin G to glutamic acid decarboxylase- 65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes. Journal of Clinical Endocrinology and Metabolism, 82 (8). pp. 2664-2670. ISSN 0021-972X

epitope mapping

Piquer, Sandra and Valera, Lionel and Lampasona, Vito and Jardin-Watelet, Benedicte and Roche, Stephanie and Granier, Claude and Roquet, Francoise and Christie, Michael R. and Giordano, Tiziana and Malosio, Maria-Luisa and Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

epstein barr virus

Tremble, Jennifer and Morgenthaler, Nils G. and Vlug, Arjen and Powers, Alvin C. and Christie, Michael R. and Scherbaum, Werner A. and Banga, J. Paul (1997) Human B cells secreting immunoglobulin G to glutamic acid decarboxylase- 65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes. Journal of Clinical Endocrinology and Metabolism, 82 (8). pp. 2664-2670. ISSN 0021-972X

escherichia coli

Morgenthaler, N. G. and Löbner, K. and Morgenthaler, U. Y. and Christie, M. R. and Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

ethanol

Calabrese, V. and Scapagnini, G. and Catalano, C. and Dinotta, F. and Bates, T. E. and Calvani, M. and Stella, A. M. (2001) Effects of acetyl-L-carnitine on the formation of fatty acid ethyl esters in brain and peripheral organs after short-term ethanol administration in rat. Neurochemical Research, 26 (2). pp. 167-74. ISSN 0364-3190

Calabrese, Vittorio and Testa, Guiseppe and Ravagna, Agrippino and Bates, Timothy Edward and Stella, Anna Maria (2000) HSP70 induction in the brain following ethanol administration in the rat: regulation by glutathione redox state. Biochemical and Biophysical Research Communications, 269 (2). pp. 397-400. ISSN 0006-291X

ethnic group

Damanhouri, L. H. and Dromey, J. A. and Christie, Michael R. and Nasrat, H. A. and Ardawi, M. S. M. and Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

etiology

Bonifacio, E. and Christie, M. R. (1996) Tyrosine phosphatase-like proteins as autoantigens in insulin-dependent diabetes mellitus: the targets for 37/40k antibodies. Diabetes, Nutrition and Metabolism - Clinical and Experimental, 9 (4). pp. 183-187. ISSN 0394-3402

Hatfield, E. C. I. and Hawkes, C. J. and Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Roll, U. and Christie, M. R. and Fuchtenbusch, M. and Payton, M. A. and Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

excitotoxicity

Rosin, Claudia and Bates, Timothy E. and Skaper, Stephen D. (2004) Excitatory amino acid induced oligodendrocyte cell death in vitro: receptor-dependent and -independent mechanisms. Journal of Neurochemistry, 90 (5). pp. 1173-1185. ISSN 0022-3042

exocrine cell

Zhao, M. and Amiel, S. A. and Christie, Michael R. and Rela, M. and Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

familial disease

Seissler, J. and Morgenthaler, N. G. and Achenbach, P. and Lampeter, E .F. and Glawe, D. and Payton, M. and Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

family

Seissler, J. and Morgenthaler, N. G. and Achenbach, P. and Lampeter, E .F. and Glawe, D. and Payton, M. and Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

family study

Bingley, P. J. and Christie, M. R. and Bonifacio, E. and Bonfanti, R. and Shattock, M. and Fonte, M.-T. and Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

fatty acids

Dagnelie, Pieter C. and Bell, Jimmy D. and Williams, Steve C. and Bates, Timothy E. and Abel, Paul D. and Foster, Christopher S. (1994) Effect of fish oil on cancer cachexia and host liver metabolism in rats with prostate tumors. Lipids, 29 (3). pp. 195-203. ISSN 0024-4201

female

Bingley, P. J. and Christie, M. R. and Bonifacio, E. and Bonfanti, R. and Shattock, M. and Fonte, M.-T. and Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Christie, M. R. and Genovese, S. and Cassidy, D. and Bosi, E. and Brown, T. J. and Lai, M. and Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

Christie, M. R. and Tun, R. Y. M. and Lo, S. S. S. and Cassidy, D. and Brown, T. J. and Hollands, J. and Shattock, M. and Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Christie, Michael and Brown, T. J. and Cassidy, D. (1992) Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme. Diabetologia, 35 (4). pp. 380-384. ISSN 0012-186X

Christie, Michael R. and Molvig, Jens and Hawkes, Charlotte J. and Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

Christie, Michael R. and Roll, Ursula and Payton, Mark A. and Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Damanhouri, L. H. and Dromey, J. A. and Christie, Michael R. and Nasrat, H. A. and Ardawi, M. S. M. and Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Desai, M.a and Cull, C.A.b and Horton, V.A.a and Christie, M.R.c and Bonifacio, E.d and Lampasona, V.d and Bingley, P.J.e and Levy, J.C.a and Mackay, I.R.f and Zimmet, P.g and Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Gillespie, Kathleen M. and Bain, Steven C. and Barnett, Anthony H. and Bingley, Polly J. and Christie, Michael R. and Gill, Geoffrey V. and Gale, Edwin A. M. (2004) The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. The Lancet, 364 (9446). pp. 1699-1700. ISSN 0140-6736

Gylling, Mikhail and Tuomi, Tiinamaija and Bjorses, Petra and Kontiainen, Sirkka and Partanen, Jukka and Christie, Michael R. and Knip, Mikael and Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

Hawa, M. and Rowe, R. and Lan, M. S. and Notkins, A. L. and Pozzilli, P. and Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Lampeter, E. F. and Kolb, H. and Seifert, I. and Lohmann, D. and Heise, J. W. and Bertrams, J. and Christie, Michael and Kolb-Bachofen, V. (1994) Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity. Diabetologia, 37 (5). pp. 471-475. ISSN 0012-186X

Morgenthaler, N. G. and Seissler, J. and Achenbach, P. and Glawe, D. and Payton, M. and Meinck, H.-M. and Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Roll, U. and Christie, M. R. and Fuchtenbusch, M. and Payton, M. A. and Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Roll, U. and Christie, M. R. and Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

Seissler, J. and Morgenthaler, N. G. and Achenbach, P. and Lampeter, E .F. and Glawe, D. and Payton, M. and Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

Wagner, R. and Genovese, S. and Bosi, E. and Becker, F. and Bingley, P. J. and Bonifacio, E. and Miles, K. A. and Christie, Michael and Bottazzo, G. F. and Gale, E. A. M. (1994) Slow metabolic deterioration towards diabetes in islet cell antibody positive patients with autoimmune polyendocrine disease. Diabetologia, 37 (4). pp. 365-371. ISSN 0012-186X

Wagner, R. and McNally, J. M. and Bonifacio, E. and Genovese, S. and Foulis, A. and McGill, M. and Christie, M. R. and Betterle, C. and Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

Winnock, Frederic and Christie, Michael R. and Batstra, Manou R. and Aanstoot, Henk-Jan and Weets, Ilse and Decochez, Katelijn and Jopart, Philippe and Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

Zhao, M. and Christie, M.R. and Heaton, N. and George, S. and Amiel, S. and Huang, G.C. (2002) Amelioration of streptozotocin-induced diabetes in mice using human islet cells derived from long-term culture in vitro. Transplantation, 73 (9). pp. 1454-1460. ISSN 0041-1337

fibroblast

Calabrese, V. and Scapagnini, G. and Catalano, C. and Bates, T. E. and Dinotta, F. and Micali, G. and Giuffrida Stella, A. M. (2001) Induction of heat shock protein synthesis in human skin fibroblasts in response to oxidative stress: regulation by a natural antioxidant from rosemary extract. International Journal of Tissue Reactions, 23 (2). pp. 51-8. ISSN 0250-0868

Calabrese, V. and Scapagnini, G. and Catalano, C. and Bates, T. E. and Geraci, D. and Pennisi, G. and Giuffrida Stella, A. M. (2001) Regulation of heat shock protein synthesis in human skin fibroblasts in response to oxidative stress: role of vitamin E. International Journal of Tissue Reactions, 23 (4). pp. 127-35. ISSN 0250-0868

fluorescent antibody technique

Seissler, J. and Morgenthaler, N. G. and Achenbach, P. and Lampeter, E .F. and Glawe, D. and Payton, M. and Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

follow up

Bingley, P. J. and Christie, M. R. and Bonifacio, E. and Bonfanti, R. and Shattock, M. and Fonte, M.-T. and Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Christie, M. R. and Daneman, D. and Champagne, P. and Delovitch, T. L. (1990) Persistence of serum antibodies to 64,000-Mr islet cell protein after onset of type I diabetes. Diabetes, 39 (6). pp. 653-656. ISSN 0012-1797

Christie, Michael R. and Molvig, Jens and Hawkes, Charlotte J. and Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

Desai, M.a and Cull, C.A.b and Horton, V.A.a and Christie, M.R.c and Bonifacio, E.d and Lampasona, V.d and Bingley, P.J.e and Levy, J.C.a and Mackay, I.R.f and Zimmet, P.g and Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Seissler, J. and Morgenthaler, N. G. and Achenbach, P. and Lampeter, E .F. and Glawe, D. and Payton, M. and Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

free radicals

Calabrese, Vittorio and Bates, Timothy E. and Mancuso, Cesare and Cornelius, Carolin and Ventimiglia, Bernardo and Cambria, Maria Teresa and Di Renzo, Laura and De Lorenzo, Antonino and Dinkova-Kostova, Albena T. (2008) Curcumin and the cellular stress response in free radical-related diseases. Molecular Nutrition & Food Research, 52 (9). pp. 1062-1073. ISSN 1613-4125

function

Calabrese, V. and Scapagnini, G. and Giuffrida Stella, A. M. and Bates, T. E. and Clark, J. B. (2001) Mitochondrial involvement in brain function and dysfunction: relevance to aging, neurodegenerative disorders and longevity. Neurochemical Research, 26 (6). pp. 739-64. ISSN 0364-3190

gene

Gylling, Mikhail and Tuomi, Tiinamaija and Bjorses, Petra and Kontiainen, Sirkka and Partanen, Jukka and Christie, Michael R. and Knip, Mikael and Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

gene mapping

Hawkes, C. J. and Schloot, N. C. and Marks, J. and Willemen, S. J. M. and Drijfhout, J. W. and Mayer, E. K. and Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

genetic marker

Christie, M. R. and Genovese, S. and Cassidy, D. and Bosi, E. and Brown, T. J. and Lai, M. and Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

Christie, M. R. and Tun, R. Y. M. and Lo, S. S. S. and Cassidy, D. and Brown, T. J. and Hollands, J. and Shattock, M. and Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

genetic polymorphism

Winnock, Frederic and Christie, Michael R. and Batstra, Manou R. and Aanstoot, Henk-Jan and Weets, Ilse and Decochez, Katelijn and Jopart, Philippe and Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

genetic predisposition

Christie, M. R. and Genovese, S. and Cassidy, D. and Bosi, E. and Brown, T. J. and Lai, M. and Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

genetic susceptibility

Christie, M. R. and Tun, R. Y. M. and Lo, S. S. S. and Cassidy, D. and Brown, T. J. and Hollands, J. and Shattock, M. and Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Gillespie, Kathleen M. and Bain, Steven C. and Barnett, Anthony H. and Bingley, Polly J. and Christie, Michael R. and Gill, Geoffrey V. and Gale, Edwin A. M. (2004) The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. The Lancet, 364 (9446). pp. 1699-1700. ISSN 0140-6736

Gorus, F. K. and Goubert, P. and Semakula, C. and Vandewalle, C. L. and De Schepper, J. and Scheen, A. and Christie, Michael R. and Pipeleers, D. G. (1997) IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia, 40 (1). pp. 95-99. ISSN 0012-186X

Hawkes, C. J. and Schloot, N. C. and Marks, J. and Willemen, S. J. M. and Drijfhout, J. W. and Mayer, E. K. and Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

Roll, U. and Christie, M. R. and Fuchtenbusch, M. and Payton, M. A. and Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

genetic transfection

Zhao, M. and Amiel, S. A. and Christie, Michael R. and Rela, M. and Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

genetics

Gylling, Mikhail and Tuomi, Tiinamaija and Bjorses, Petra and Kontiainen, Sirkka and Partanen, Jukka and Christie, Michael R. and Knip, Mikael and Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

Winnock, Frederic and Christie, Michael R. and Batstra, Manou R. and Aanstoot, Henk-Jan and Weets, Ilse and Decochez, Katelijn and Jopart, Philippe and Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

genotype

Bearzatto, Massimo and Naserke, Heike and Piquer, Sandra and Koczwara, Kerstin and Lampasona, Vito and Williams, Alistair and Christie, Michael R. and Bingley, Polly J. and Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Gillespie, Kathleen M. and Bain, Steven C. and Barnett, Anthony H. and Bingley, Polly J. and Christie, Michael R. and Gill, Geoffrey V. and Gale, Edwin A. M. (2004) The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. The Lancet, 364 (9446). pp. 1699-1700. ISSN 0140-6736

Winnock, Frederic and Christie, Michael R. and Batstra, Manou R. and Aanstoot, Henk-Jan and Weets, Ilse and Decochez, Katelijn and Jopart, Philippe and Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

glioma

Daley, E. and Wilkie, D. and Loesch, A. and Hargreaves, I. P. and Kendall, D. A. and Pilkington, G. J. and Bates, T. E. (2005) Chlorimipramine: a novel anticancer agent with a mitochondrial target. Biochemical and Biophysical Research Communications, 328 (2). pp. 623-632. ISSN 0006-291X

glucagon

Christie, Michael R. and Molvig, Jens and Hawkes, Charlotte J. and Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

glucose

Zhao, M. and Amiel, S. A. and Christie, Michael R. and Rela, M. and Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

glucose blood level

Huang, Guo Cai and Zhao, Min and Jones, Peter and Persaud, Shanta and Ramracheya, Reshma and Lobner, Kristian and Christie, Michael R. and Banga, J. Paul and Peakman, Mark and Sirinivsan, Parthi and Rela, Mohammed and Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

glucose tolerance test

Gylling, Mikhail and Tuomi, Tiinamaija and Bjorses, Petra and Kontiainen, Sirkka and Partanen, Jukka and Christie, Michael R. and Knip, Mikael and Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

Wagner, R. and Genovese, S. and Bosi, E. and Becker, F. and Bingley, P. J. and Bonifacio, E. and Miles, K. A. and Christie, Michael and Bottazzo, G. F. and Gale, E. A. M. (1994) Slow metabolic deterioration towards diabetes in islet cell antibody positive patients with autoimmune polyendocrine disease. Diabetologia, 37 (4). pp. 365-371. ISSN 0012-186X

glutamate

Rosin, Claudia and Bates, Timothy E. and Skaper, Stephen D. (2004) Excitatory amino acid induced oligodendrocyte cell death in vitro: receptor-dependent and -independent mechanisms. Journal of Neurochemistry, 90 (5). pp. 1173-1185. ISSN 0022-3042

glutamate decarboxylase

Bingley, P. J. and Christie, M. R. and Bonifacio, E. and Bonfanti, R. and Shattock, M. and Fonte, M.-T. and Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Bonifacio, E. and Christie, M. R. (1997) Islet cell antigens in the prediction and prevention of insulin-dependent diabetes mellitus. Annals of Medicine, 29 (5). pp. 405-412. ISSN 0785-3890

Bonifacio, E. and Christie, M. R. (1996) Tyrosine phosphatase-like proteins as autoantigens in insulin-dependent diabetes mellitus: the targets for 37/40k antibodies. Diabetes, Nutrition and Metabolism - Clinical and Experimental, 9 (4). pp. 183-187. ISSN 0394-3402

Christie, M. R. (1993) Characterization of distinct islet protein auto antigens associated with type 1 diabetes. Autoimmunity, 15 (s1). pp. 1-3. ISSN 0891-6934

Christie, M. R. (1996) Islet cell autoantigens in type 1 diabetes. European Journal of Clinical Investigation, 26 (10). pp. 827-838. ISSN 0014-2972

Christie, M. R. and Genovese, S. and Cassidy, D. and Bosi, E. and Brown, T. J. and Lai, M. and Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

Christie, M. R. and Hollands, J. A. and Brown, T. J. and Michelsen, B. K. and Delovitch, T. L. (1993) Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. Journal of Clinical Investigation, 92 (1). pp. 240-248. ISSN 0021-9738

Christie, M. R. and Tun, R. Y. M. and Lo, S. S. S. and Cassidy, D. and Brown, T. J. and Hollands, J. and Shattock, M. and Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Christie, Michael R. and Roll, Ursula and Payton, Mark A. and Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Gylling, Mikhail and Tuomi, Tiinamaija and Bjorses, Petra and Kontiainen, Sirkka and Partanen, Jukka and Christie, Michael R. and Knip, Mikael and Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

Hawa, M. and Rowe, R. and Lan, M. S. and Notkins, A. L. and Pozzilli, P. and Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Morgenthaler, N. G. and Seissler, J. and Achenbach, P. and Glawe, D. and Payton, M. and Meinck, H.-M. and Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Roll, U. and Christie, M. R. and Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

Seissler, J. and Morgenthaler, N. G. and Achenbach, P. and Lampeter, E .F. and Glawe, D. and Payton, M. and Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

Tremble, Jennifer and Morgenthaler, Nils G. and Vlug, Arjen and Powers, Alvin C. and Christie, Michael R. and Scherbaum, Werner A. and Banga, J. Paul (1997) Human B cells secreting immunoglobulin G to glutamic acid decarboxylase- 65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes. Journal of Clinical Endocrinology and Metabolism, 82 (8). pp. 2664-2670. ISSN 0021-972X

Wagner, R. and McNally, J. M. and Bonifacio, E. and Genovese, S. and Foulis, A. and McGill, M. and Christie, M. R. and Betterle, C. and Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

Winnock, Frederic and Christie, Michael R. and Batstra, Manou R. and Aanstoot, Henk-Jan and Weets, Ilse and Decochez, Katelijn and Jopart, Philippe and Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

glutamate decarboxylase 65

Gylling, Mikhail and Tuomi, Tiinamaija and Bjorses, Petra and Kontiainen, Sirkka and Partanen, Jukka and Christie, Michael R. and Knip, Mikael and Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

glutamate decarboxylase 65 antibody

Damanhouri, L. H. and Dromey, J. A. and Christie, Michael R. and Nasrat, H. A. and Ardawi, M. S. M. and Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Desai, M.a and Cull, C.A.b and Horton, V.A.a and Christie, M.R.c and Bonifacio, E.d and Lampasona, V.d and Bingley, P.J.e and Levy, J.C.a and Mackay, I.R.f and Zimmet, P.g and Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

glutamate decarboxylase, adolescent

Christie, Michael and Brown, T. J. and Cassidy, D. (1992) Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme. Diabetologia, 35 (4). pp. 380-384. ISSN 0012-186X

glutamate toxicity

Rosin, Claudia and Colombo, Sergio and Calver, Andrew A. and Bates, Timothy E. and Skaper, Stephen D. (2005) Dopamine D2 and D3 receptor agonists limit oligodendrocyte injury caused by glutamate oxidative stress and oxygen/glucose deprivation. Glia, 52 (4). pp. 336-343. ISSN 0894-1491

glutathione

Calabrese, Vittorio and Testa, Guiseppe and Ravagna, Agrippino and Bates, Timothy Edward and Stella, Anna Maria (2000) HSP70 induction in the brain following ethanol administration in the rat: regulation by glutathione redox state. Biochemical and Biophysical Research Communications, 269 (2). pp. 397-400. ISSN 0006-291X

glutatione

Brooks, Keith J and Hargreaves, Iain and Bhakoo, Kishore and Sellwood, Mark and O'Brien, Francis and Noone, Martina and Sakata, Yasuko and Cady, Ernest and Wylezinska, Marzena and Thornton, John and Ordidge, Roger and Nguyen, Quyen and Clemence, Matthew and Wyatt, John and Bates, Timothy E. (2002) Delayed hypothermia prevents decreases in N-acetylaspartate and reduced glutathione in the cerebral cortex of the neonatal pig following transient hypoxia-ischaemia. Neurochemical Research, 27 (12). pp. 1599-604. ISSN 0364-3190

glycosylated hemoglobin

Christie, Michael R. and Molvig, Jens and Hawkes, Charlotte J. and Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

glycosylation

Winnock, Frederic and Christie, Michael R. and Batstra, Manou R. and Aanstoot, Henk-Jan and Weets, Ilse and Decochez, Katelijn and Jopart, Philippe and Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

graves disease

Morgenthaler, N. G. and Löbner, K. and Morgenthaler, U. Y. and Christie, M. R. and Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Tremble, Jennifer and Morgenthaler, Nils G. and Vlug, Arjen and Powers, Alvin C. and Christie, Michael R. and Scherbaum, Werner A. and Banga, J. Paul (1997) Human B cells secreting immunoglobulin G to glutamic acid decarboxylase- 65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes. Journal of Clinical Endocrinology and Metabolism, 82 (8). pp. 2664-2670. ISSN 0021-972X

hamster

Christie, M. R. and Hollands, J. A. and Brown, T. J. and Michelsen, B. K. and Delovitch, T. L. (1993) Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. Journal of Clinical Investigation, 92 (1). pp. 240-248. ISSN 0021-9738

haplotype

Gillespie, Kathleen M. and Bain, Steven C. and Barnett, Anthony H. and Bingley, Polly J. and Christie, Michael R. and Gill, Geoffrey V. and Gale, Edwin A. M. (2004) The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. The Lancet, 364 (9446). pp. 1699-1700. ISSN 0140-6736

Gylling, Mikhail and Tuomi, Tiinamaija and Bjorses, Petra and Kontiainen, Sirkka and Partanen, Jukka and Christie, Michael R. and Knip, Mikael and Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

heat

Tew, G. A. and Saxton, J. M. and Klonizakis, Markos and Moss, J. and Ruddock, A. D. and Hodges, G. J. (2011) Aging and aerobic fitness affect the contribution of noradrenergic sympathetic nerves to the rapid cutaneous vasodilator response to local heating. Journal of Applied Physiology, 110 (5). pp. 1264-1270. ISSN 8750-7587

heat Stress

Sammut, Ivan A. and Jayakumar, Jay and Latif, Najmi and Rothery, Stephen and Severs, Nicholas J. and Smolenski, Ryszard T. and Bates, Timothy E. and Yacoub, Magdi H. (2001) Heat stress contributes to the enhancement of cardiac mitochondrial complex activity. The American Journal of Pathology, 158 (5). pp. 1821-31. ISSN 0002-9440

heat shock protein, animal cell

Christie, M. R. and Hollands, J. A. and Brown, T. J. and Michelsen, B. K. and Delovitch, T. L. (1993) Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. Journal of Clinical Investigation, 92 (1). pp. 240-248. ISSN 0021-9738

helicase

Biswas, Subhajit and Nunez Miguel, Ricardo and Sukla, Soumi and Field, Hugh J. (2009) A mutation in helicase motif IV of herpes simplex virus type 1 UL5 that results in reduced growth in vitro and lower virulence in a murine infection model is related to the predicted helicase structure. Journal of General Virology, 90 (8). pp. 1937-1942. ISSN 0022-1317

herpes simplex

Biswas, Subhajit and Nunez Miguel, Ricardo and Sukla, Soumi and Field, Hugh J. (2009) A mutation in helicase motif IV of herpes simplex virus type 1 UL5 that results in reduced growth in vitro and lower virulence in a murine infection model is related to the predicted helicase structure. Journal of General Virology, 90 (8). pp. 1937-1942. ISSN 0022-1317

high risk patient

Christie, Michael R. and Roll, Ursula and Payton, Mark A. and Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

high risk population

Gillespie, Kathleen M. and Bain, Steven C. and Barnett, Anthony H. and Bingley, Polly J. and Christie, Michael R. and Gill, Geoffrey V. and Gale, Edwin A. M. (2004) The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. The Lancet, 364 (9446). pp. 1699-1700. ISSN 0140-6736

histology

Hansen, W.A. and Christie, M.R. and Kahn, R. and Norgaard, A. and Abel, I. and Petersen, A.M. and Jorgensen, D.W. and Baekkeskov, S. and Nielsen, J.H. and Lernmark, A. and Egeberg, J. and Richter-Olesen, H. and Grainger, T. and Kristensen, J.K. and Brynitz, S. and Bilde, T. (1989) Supravital dithizone staining in the isolation of human and rat pancreatic islets. Diabetes Research, 10 (2). pp. 53-57. ISSN 0265-5985

Zhao, M. and Christie, M.R. and Heaton, N. and George, S. and Amiel, S. and Huang, G.C. (2002) Amelioration of streptozotocin-induced diabetes in mice using human islet cells derived from long-term culture in vitro. Transplantation, 73 (9). pp. 1454-1460. ISSN 0041-1337

human

Baekkeskov, S. and Warnock, G. and Christie, M. and Rajotte, R.V. and Larsen, P.M. and Fey, S. (1989) Revelation of specificity of 64K autoantibodies in IDDM serums by high-resolution 2-D gel electrophoresis. Unambiguous identification of 64K target antigen. Diabetes, 38 (9). pp. 1133-1141. ISSN 0012-1797

Bearzatto, Massimo and Naserke, Heike and Piquer, Sandra and Koczwara, Kerstin and Lampasona, Vito and Williams, Alistair and Christie, Michael R. and Bingley, Polly J. and Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Bingley, P. J. and Christie, M. R. and Bonifacio, E. and Bonfanti, R. and Shattock, M. and Fonte, M.-T. and Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Bonifacio, E. and Christie, M. R. (1997) Islet cell antigens in the prediction and prevention of insulin-dependent diabetes mellitus. Annals of Medicine, 29 (5). pp. 405-412. ISSN 0785-3890

Bonifacio, E. and Christie, M. R. (1996) Tyrosine phosphatase-like proteins as autoantigens in insulin-dependent diabetes mellitus: the targets for 37/40k antibodies. Diabetes, Nutrition and Metabolism - Clinical and Experimental, 9 (4). pp. 183-187. ISSN 0394-3402

Bottazzo, G. F. and Genovese, S. and Bosi, E. and Dean, B. M. and Christie, M. R. and Bonifacio, E. (1991) Novel considerations on the antibody/autoantigen system in type I (insulin-dependent) diabetes mellitus. Annals of Medicine, 23 (4). pp. 453-461. ISSN 0785-3890

Christie, M. R. (1993) Characterization of distinct islet protein auto antigens associated with type 1 diabetes. Autoimmunity, 15 (s1). pp. 1-3. ISSN 0891-6934

Christie, M. R. and Daneman, D. and Champagne, P. and Delovitch, T. L. (1990) Persistence of serum antibodies to 64,000-Mr islet cell protein after onset of type I diabetes. Diabetes, 39 (6). pp. 653-656. ISSN 0012-1797

Christie, M. R. and Genovese, S. and Cassidy, D. and Bosi, E. and Brown, T. J. and Lai, M. and Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

Christie, M. R. and Hollands, J. A. and Brown, T. J. and Michelsen, B. K. and Delovitch, T. L. (1993) Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. Journal of Clinical Investigation, 92 (1). pp. 240-248. ISSN 0021-9738

Christie, M. R. and Pipeleers, D. G. and Lernmark, A. and Baekkeskov, S. (1990) Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes. Journal of Biological Chemistry, 265 (1). pp. 376-381. ISSN 0021-9258

Christie, M. R. and Tun, R. Y. M. and Lo, S. S. S. and Cassidy, D. and Brown, T. J. and Hollands, J. and Shattock, M. and Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Christie, M. R. and Vohra, G. and Champagne, P. and Daneman, D. and Delovitch, T. L. (1990) Distinct antibody specificities to a 64-kD islet cell antigen in Type 1 diabetes as revealed by trypsin treatment. Journal of Experimental Medicine, 172 (3). pp. 789-794. ISSN 0022-1007

Christie, Michael and Brown, T. J. and Cassidy, D. (1992) Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme. Diabetologia, 35 (4). pp. 380-384. ISSN 0012-186X

Christie, Michael and Landin-Olsson, M. and Sundkvist, G. and Dahlquist, G. and Lernmark, A. and Baekkeskov, S. (1988) Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes. Diabetologia, 31 (8). pp. 597-602. ISSN 0012-186X

Christie, Michael R. and Molvig, Jens and Hawkes, Charlotte J. and Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

Christie, Michael R. and Roll, Ursula and Payton, Mark A. and Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Damanhouri, L. H. and Dromey, J. A. and Christie, Michael R. and Nasrat, H. A. and Ardawi, M. S. M. and Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Desai, M.a and Cull, C.A.b and Horton, V.A.a and Christie, M.R.c and Bonifacio, E.d and Lampasona, V.d and Bingley, P.J.e and Levy, J.C.a and Mackay, I.R.f and Zimmet, P.g and Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Gillespie, Kathleen M. and Bain, Steven C. and Barnett, Anthony H. and Bingley, Polly J. and Christie, Michael R. and Gill, Geoffrey V. and Gale, Edwin A. M. (2004) The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. The Lancet, 364 (9446). pp. 1699-1700. ISSN 0140-6736

Gorus, F. K. and Goubert, P. and Semakula, C. and Vandewalle, C. L. and De Schepper, J. and Scheen, A. and Christie, Michael R. and Pipeleers, D. G. (1997) IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia, 40 (1). pp. 95-99. ISSN 0012-186X

Gylling, Mikhail and Tuomi, Tiinamaija and Bjorses, Petra and Kontiainen, Sirkka and Partanen, Jukka and Christie, Michael R. and Knip, Mikael and Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

Hansen, W.A. and Christie, M.R. and Kahn, R. and Norgaard, A. and Abel, I. and Petersen, A.M. and Jorgensen, D.W. and Baekkeskov, S. and Nielsen, J.H. and Lernmark, A. and Egeberg, J. and Richter-Olesen, H. and Grainger, T. and Kristensen, J.K. and Brynitz, S. and Bilde, T. (1989) Supravital dithizone staining in the isolation of human and rat pancreatic islets. Diabetes Research, 10 (2). pp. 53-57. ISSN 0265-5985

Hatfield, E. C. I. and Hawkes, C. J. and Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Hawa, M. and Rowe, R. and Lan, M. S. and Notkins, A. L. and Pozzilli, P. and Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Hawkes, C. J. and Schloot, N. C. and Marks, J. and Willemen, S. J. M. and Drijfhout, J. W. and Mayer, E. K. and Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

Hawkes, C. J. and Wasmeier, C. and Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Huang, Guo Cai and Zhao, Min and Jones, Peter and Persaud, Shanta and Ramracheya, Reshma and Lobner, Kristian and Christie, Michael R. and Banga, J. Paul and Peakman, Mark and Sirinivsan, Parthi and Rela, Mohammed and Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Lampeter, E. F. and Kolb, H. and Seifert, I. and Lohmann, D. and Heise, J. W. and Bertrams, J. and Christie, Michael and Kolb-Bachofen, V. (1994) Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity. Diabetologia, 37 (5). pp. 471-475. ISSN 0012-186X

Morgenthaler, N. G. and Löbner, K. and Morgenthaler, U. Y. and Christie, M. R. and Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Morgenthaler, N. G. and Seissler, J. and Achenbach, P. and Glawe, D. and Payton, M. and Meinck, H.-M. and Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Payton, M. A. and Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Piquer, Sandra and Valera, Lionel and Lampasona, Vito and Jardin-Watelet, Benedicte and Roche, Stephanie and Granier, Claude and Roquet, Francoise and Christie, Michael R. and Giordano, Tiziana and Malosio, Maria-Luisa and Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

Roll, U. and Christie, M. R. and Fuchtenbusch, M. and Payton, M. A. and Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Roll, U. and Christie, M. R. and Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

Seissler, J. and Morgenthaler, N. G. and Achenbach, P. and Lampeter, E .F. and Glawe, D. and Payton, M. and Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

Tremble, Jennifer and Morgenthaler, Nils G. and Vlug, Arjen and Powers, Alvin C. and Christie, Michael R. and Scherbaum, Werner A. and Banga, J. Paul (1997) Human B cells secreting immunoglobulin G to glutamic acid decarboxylase- 65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes. Journal of Clinical Endocrinology and Metabolism, 82 (8). pp. 2664-2670. ISSN 0021-972X

Wagner, R. and Genovese, S. and Bosi, E. and Becker, F. and Bingley, P. J. and Bonifacio, E. and Miles, K. A. and Christie, Michael and Bottazzo, G. F. and Gale, E. A. M. (1994) Slow metabolic deterioration towards diabetes in islet cell antibody positive patients with autoimmune polyendocrine disease. Diabetologia, 37 (4). pp. 365-371. ISSN 0012-186X

Wagner, R. and McNally, J. M. and Bonifacio, E. and Genovese, S. and Foulis, A. and McGill, M. and Christie, M. R. and Betterle, C. and Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

Winnock, Frederic and Christie, Michael R. and Batstra, Manou R. and Aanstoot, Henk-Jan and Weets, Ilse and Decochez, Katelijn and Jopart, Philippe and Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

Zhao, M. and Amiel, S. A. and Christie, Michael R. and Rela, M. and Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Zhao, M. and Christie, M.R. and Heaton, N. and George, S. and Amiel, S. and Huang, G.C. (2002) Amelioration of streptozotocin-induced diabetes in mice using human islet cells derived from long-term culture in vitro. Transplantation, 73 (9). pp. 1454-1460. ISSN 0041-1337

human cell

Baekkeskov, S. and Warnock, G. and Christie, M. and Rajotte, R.V. and Larsen, P.M. and Fey, S. (1989) Revelation of specificity of 64K autoantibodies in IDDM serums by high-resolution 2-D gel electrophoresis. Unambiguous identification of 64K target antigen. Diabetes, 38 (9). pp. 1133-1141. ISSN 0012-1797

Christie, M. R. and Pipeleers, D. G. and Lernmark, A. and Baekkeskov, S. (1990) Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes. Journal of Biological Chemistry, 265 (1). pp. 376-381. ISSN 0021-9258

Christie, M. R. and Vohra, G. and Champagne, P. and Daneman, D. and Delovitch, T. L. (1990) Distinct antibody specificities to a 64-kD islet cell antigen in Type 1 diabetes as revealed by trypsin treatment. Journal of Experimental Medicine, 172 (3). pp. 789-794. ISSN 0022-1007

Hansen, W.A. and Christie, M.R. and Kahn, R. and Norgaard, A. and Abel, I. and Petersen, A.M. and Jorgensen, D.W. and Baekkeskov, S. and Nielsen, J.H. and Lernmark, A. and Egeberg, J. and Richter-Olesen, H. and Grainger, T. and Kristensen, J.K. and Brynitz, S. and Bilde, T. (1989) Supravital dithizone staining in the isolation of human and rat pancreatic islets. Diabetes Research, 10 (2). pp. 53-57. ISSN 0265-5985

Hawkes, C. J. and Wasmeier, C. and Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Piquer, Sandra and Valera, Lionel and Lampasona, Vito and Jardin-Watelet, Benedicte and Roche, Stephanie and Granier, Claude and Roquet, Francoise and Christie, Michael R. and Giordano, Tiziana and Malosio, Maria-Luisa and Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

Tremble, Jennifer and Morgenthaler, Nils G. and Vlug, Arjen and Powers, Alvin C. and Christie, Michael R. and Scherbaum, Werner A. and Banga, J. Paul (1997) Human B cells secreting immunoglobulin G to glutamic acid decarboxylase- 65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes. Journal of Clinical Endocrinology and Metabolism, 82 (8). pp. 2664-2670. ISSN 0021-972X

Zhao, M. and Amiel, S. A. and Christie, Michael R. and Rela, M. and Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Zhao, M. and Christie, M.R. and Heaton, N. and George, S. and Amiel, S. and Huang, G.C. (2002) Amelioration of streptozotocin-induced diabetes in mice using human islet cells derived from long-term culture in vitro. Transplantation, 73 (9). pp. 1454-1460. ISSN 0041-1337

human cell culture

Zhao, M. and Christie, M.R. and Heaton, N. and George, S. and Amiel, S. and Huang, G.C. (2002) Amelioration of streptozotocin-induced diabetes in mice using human islet cells derived from long-term culture in vitro. Transplantation, 73 (9). pp. 1454-1460. ISSN 0041-1337

human tissue

Huang, Guo Cai and Zhao, Min and Jones, Peter and Persaud, Shanta and Ramracheya, Reshma and Lobner, Kristian and Christie, Michael R. and Banga, J. Paul and Peakman, Mark and Sirinivsan, Parthi and Rela, Mohammed and Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Morgenthaler, N. G. and Löbner, K. and Morgenthaler, U. Y. and Christie, M. R. and Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Wagner, R. and McNally, J. M. and Bonifacio, E. and Genovese, S. and Foulis, A. and McGill, M. and Christie, M. R. and Betterle, C. and Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

humoral immunity

Roll, U. and Christie, M. R. and Fuchtenbusch, M. and Payton, M. A. and Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

hybrid protein

Morgenthaler, N. G. and Löbner, K. and Morgenthaler, U. Y. and Christie, M. R. and Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

hydrazine

Kenyon, Susan H. and Waterfield, Catherine J. and Asker, Daniel S. and Kudo, Mariko and Moss, David W. and Bates, Timothy E. and Nicolaou, Anna and Gibbons, William A. and Timbrell, John A. (1999) Effect of hydrazine upon vitamin B12-dependent methionine synthase activity and the sulphur amino acid pathway in isolated rat hepatocytes. Biochemical Pharmacology, 57 (11). pp. 1311-1319. ISSN 0006-2952

hydrogen peroxide

Athanasiou, Andriani and Clarke, Anna B. and Turner, Amy E. and Kumaran, Nethia M. and Vakilpour, Sara and Smith, Paul A. and Bagiokou, Dimitra and Bradshaw, Tracey D. and Westwell, Andrew D. and Fang, Lin and Lobo, Dileep N. and Constantinescu, Cris S. and Calabrese, Vittorio and Loesch, Andrzej and Alexander, Stephen P. H. and Clothier, Richard H. and Kendall, David A. and Bates, Timothy E. (2007) Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications, 364 (1). pp. 131-137. ISSN 0006-291x

hyperglycemia

Zhao, M. and Amiel, S. A. and Christie, Michael R. and Rela, M. and Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

hypothermia

Brooks, Keith J and Hargreaves, Iain and Bhakoo, Kishore and Sellwood, Mark and O'Brien, Francis and Noone, Martina and Sakata, Yasuko and Cady, Ernest and Wylezinska, Marzena and Thornton, John and Ordidge, Roger and Nguyen, Quyen and Clemence, Matthew and Wyatt, John and Bates, Timothy E. (2002) Delayed hypothermia prevents decreases in N-acetylaspartate and reduced glutathione in the cerebral cortex of the neonatal pig following transient hypoxia-ischaemia. Neurochemical Research, 27 (12). pp. 1599-604. ISSN 0364-3190

hypoxia

Brooks, K. J. and Clark, J. B. and Bates, T. E. (1996) Assessment of energy metabolism in the developing brain following aglycemic hypoxia by 1H and 31P NMR. Neurochemical Research, 21 (9). pp. 1089-1095. ISSN 0364-3190

Brooks, K. J. and Hargreaves, I. P. and Bates, T. E. (2000) Nitric-oxide-induced inhibition of mitochondrial complexes following aglycaemic hypoxia in neonatal cortical rat brain slices. Developmental Neuroscience, 22 (5-6). pp. 359-65. ISSN 0378-5866

Brooks, Keith J. and Clark, John B. and Bates, Timothy E. (1998) 3-Hydroxybutyrate aids the recovery of the energy state from aglycaemic hypoxia of adult but not neonatal rat brain slices. Journal of Neurochemistry, 70 (5). pp. 1986-1990. ISSN 0022-3042

Keelan, J. and Brand, M. P. and Bates, T. E. and Land, J. M. and Clark, J. B. and Heales, S. J. (1996) Nitric oxide and antioxidant status in glucose and oxygen deprived neonatal and adult rat brain synaptosomes. Neurochemical Research, 21 (8). pp. 923-7. ISSN 0364-3190

Keelan, Julie and Bates, Timothy E. and Clark, John B. (1996) Intrasynaptosomal free calcium concentration during rat brain development: effects of hypoxia, aglycaemia, and ischaemia. Journal of neurochemistry, 66 (6). pp. 2460-7. ISSN 0022-3042

ia 2 antibody

Damanhouri, L. H. and Dromey, J. A. and Christie, Michael R. and Nasrat, H. A. and Ardawi, M. S. M. and Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

immune response

Bonifacio, E. and Christie, M. R. (1997) Islet cell antigens in the prediction and prevention of insulin-dependent diabetes mellitus. Annals of Medicine, 29 (5). pp. 405-412. ISSN 0785-3890

Christie, M. R. and Daneman, D. and Champagne, P. and Delovitch, T. L. (1990) Persistence of serum antibodies to 64,000-Mr islet cell protein after onset of type I diabetes. Diabetes, 39 (6). pp. 653-656. ISSN 0012-1797

immunoassay

Christie, M. R. (1993) Characterization of distinct islet protein auto antigens associated with type 1 diabetes. Autoimmunity, 15 (s1). pp. 1-3. ISSN 0891-6934

immunoblotting

Tremble, Jennifer and Morgenthaler, Nils G. and Vlug, Arjen and Powers, Alvin C. and Christie, Michael R. and Scherbaum, Werner A. and Banga, J. Paul (1997) Human B cells secreting immunoglobulin G to glutamic acid decarboxylase- 65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes. Journal of Clinical Endocrinology and Metabolism, 82 (8). pp. 2664-2670. ISSN 0021-972X

immunocytochemistry

Hansen, W.A. and Christie, M.R. and Kahn, R. and Norgaard, A. and Abel, I. and Petersen, A.M. and Jorgensen, D.W. and Baekkeskov, S. and Nielsen, J.H. and Lernmark, A. and Egeberg, J. and Richter-Olesen, H. and Grainger, T. and Kristensen, J.K. and Brynitz, S. and Bilde, T. (1989) Supravital dithizone staining in the isolation of human and rat pancreatic islets. Diabetes Research, 10 (2). pp. 53-57. ISSN 0265-5985

immunofluorescence

Christie, M. R. and Tun, R. Y. M. and Lo, S. S. S. and Cassidy, D. and Brown, T. J. and Hollands, J. and Shattock, M. and Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Wagner, R. and McNally, J. M. and Bonifacio, E. and Genovese, S. and Foulis, A. and McGill, M. and Christie, M. R. and Betterle, C. and Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

immunofluorescence test

Christie, Michael and Landin-Olsson, M. and Sundkvist, G. and Dahlquist, G. and Lernmark, A. and Baekkeskov, S. (1988) Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes. Diabetologia, 31 (8). pp. 597-602. ISSN 0012-186X

immunoglobulin g, article

Tremble, Jennifer and Morgenthaler, Nils G. and Vlug, Arjen and Powers, Alvin C. and Christie, Michael R. and Scherbaum, Werner A. and Banga, J. Paul (1997) Human B cells secreting immunoglobulin G to glutamic acid decarboxylase- 65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes. Journal of Clinical Endocrinology and Metabolism, 82 (8). pp. 2664-2670. ISSN 0021-972X

immunohistochemistry

Wagner, R. and McNally, J. M. and Bonifacio, E. and Genovese, S. and Foulis, A. and McGill, M. and Christie, M. R. and Betterle, C. and Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

immunology

Christie, Michael and Landin-Olsson, M. and Sundkvist, G. and Dahlquist, G. and Lernmark, A. and Baekkeskov, S. (1988) Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes. Diabetologia, 31 (8). pp. 597-602. ISSN 0012-186X

Christie, Michael R. and Molvig, Jens and Hawkes, Charlotte J. and Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

Gylling, Mikhail and Tuomi, Tiinamaija and Bjorses, Petra and Kontiainen, Sirkka and Partanen, Jukka and Christie, Michael R. and Knip, Mikael and Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

Seissler, J. and Morgenthaler, N. G. and Achenbach, P. and Lampeter, E .F. and Glawe, D. and Payton, M. and Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

Winnock, Frederic and Christie, Michael R. and Batstra, Manou R. and Aanstoot, Henk-Jan and Weets, Ilse and Decochez, Katelijn and Jopart, Philippe and Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

immunoprecipitation

Bonifacio, E. and Christie, M. R. (1996) Tyrosine phosphatase-like proteins as autoantigens in insulin-dependent diabetes mellitus: the targets for 37/40k antibodies. Diabetes, Nutrition and Metabolism - Clinical and Experimental, 9 (4). pp. 183-187. ISSN 0394-3402

Christie, M. R. (1993) Characterization of distinct islet protein auto antigens associated with type 1 diabetes. Autoimmunity, 15 (s1). pp. 1-3. ISSN 0891-6934

Christie, M. R. and Hollands, J. A. and Brown, T. J. and Michelsen, B. K. and Delovitch, T. L. (1993) Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. Journal of Clinical Investigation, 92 (1). pp. 240-248. ISSN 0021-9738

Christie, M. R. and Tun, R. Y. M. and Lo, S. S. S. and Cassidy, D. and Brown, T. J. and Hollands, J. and Shattock, M. and Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Christie, M. R. and Vohra, G. and Champagne, P. and Daneman, D. and Delovitch, T. L. (1990) Distinct antibody specificities to a 64-kD islet cell antigen in Type 1 diabetes as revealed by trypsin treatment. Journal of Experimental Medicine, 172 (3). pp. 789-794. ISSN 0022-1007

Hawkes, C. J. and Wasmeier, C. and Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Morgenthaler, N. G. and Löbner, K. and Morgenthaler, U. Y. and Christie, M. R. and Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Payton, M. A. and Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Tremble, Jennifer and Morgenthaler, Nils G. and Vlug, Arjen and Powers, Alvin C. and Christie, Michael R. and Scherbaum, Werner A. and Banga, J. Paul (1997) Human B cells secreting immunoglobulin G to glutamic acid decarboxylase- 65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes. Journal of Clinical Endocrinology and Metabolism, 82 (8). pp. 2664-2670. ISSN 0021-972X

immunostimulation

Hawkes, C. J. and Schloot, N. C. and Marks, J. and Willemen, S. J. M. and Drijfhout, J. W. and Mayer, E. K. and Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

immunosuppressive agent

Christie, Michael R. and Molvig, Jens and Hawkes, Charlotte J. and Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

immunosuppressive treatment

Christie, Michael R. and Molvig, Jens and Hawkes, Charlotte J. and Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

impaired glucose tolerance

Desai, M.a and Cull, C.A.b and Horton, V.A.a and Christie, M.R.c and Bonifacio, E.d and Lampasona, V.d and Bingley, P.J.e and Levy, J.C.a and Mackay, I.R.f and Zimmet, P.g and Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Winnock, Frederic and Christie, Michael R. and Batstra, Manou R. and Aanstoot, Henk-Jan and Weets, Ilse and Decochez, Katelijn and Jopart, Philippe and Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

incidence

Gillespie, Kathleen M. and Bain, Steven C. and Barnett, Anthony H. and Bingley, Polly J. and Christie, Michael R. and Gill, Geoffrey V. and Gale, Edwin A. M. (2004) The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. The Lancet, 364 (9446). pp. 1699-1700. ISSN 0140-6736

infant

Christie, Michael and Landin-Olsson, M. and Sundkvist, G. and Dahlquist, G. and Lernmark, A. and Baekkeskov, S. (1988) Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes. Diabetologia, 31 (8). pp. 597-602. ISSN 0012-186X

Christie, Michael R. and Roll, Ursula and Payton, Mark A. and Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Hatfield, E. C. I. and Hawkes, C. J. and Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Roll, U. and Christie, M. R. and Fuchtenbusch, M. and Payton, M. A. and Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Seissler, J. and Morgenthaler, N. G. and Achenbach, P. and Lampeter, E .F. and Glawe, D. and Payton, M. and Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

Winnock, Frederic and Christie, Michael R. and Batstra, Manou R. and Aanstoot, Henk-Jan and Weets, Ilse and Decochez, Katelijn and