(E) - capsaicin

Athanasiou, Andriani and Smith, Paul A. and Vakilpour, Sara and Kumaran, Nethia M. and Turner, Amy E. and Bagiokou, Dimitra and Layfield, Robert and Ray, David E. and Westwell, Andrew D. and Alexander, Stephen P. H. and Kendall, David A. and Lobo, Dileep N. and Watson, Susan A. and Lophatanon, Artitaya and Muir, Kenneth A. and Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

1-methyl-4-phenylpyridinium

Bates, T. E. and Heales, S. J. and Davies, S. E. and Boakye, P. and Clark, J. B. (1994) Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. Journal of neurochemistry, 63 (2). pp. 640-648. ISSN 0022-3042

13C

Bakken, Inger J. and Sonnewald, Ursula and Clark, John B. and Bates, Timothy E. (1997) [U-13C]glutamate metabolism in rat brain mitochondria reveals malic enzyme activity. Neuroreport, 8 (7). pp. 1567-1570. ISSN 0959-4965

1H

Bates, Timothy E. and Strangward, Maria and Keelan, Julia and Davey, Gavin P. and Munro, Peter M. G. and Clark, John B. (1996) Inhibition of N-acetylaspartate production: implications for 1H MRS studies in vivo. Neuroreport, 7 (8). pp. 1397-1400. ISSN 0959-4965

Brooks, K. J. and Clark, J. B. and Bates, T. E. (1996) Assessment of energy metabolism in the developing brain following aglycemic hypoxia by 1H and 31P NMR. Neurochemical Research, 21 (9). pp. 1089-1095. ISSN 0364-3190

31P

Brooks, K. J. and Clark, J. B. and Bates, T. E. (1996) Assessment of energy metabolism in the developing brain following aglycemic hypoxia by 1H and 31P NMR. Neurochemical Research, 21 (9). pp. 1089-1095. ISSN 0364-3190

Dagnelie, P. C. and Bell, J. D. and Williams, S. C. and Bates, T. E. and Abel, P. D. and Foster, C. S. (1993) Altered phosphorylation status, phospholipid metabolism and gluconeogenesis in the host liver of rats with prostate cancer: a 31P magnetic resonance spectroscopy study. British Journal of Cancer, 67 (6). pp. 1303-1309. ISSN 0007-0920

Dagnelie, Pieter C. and Bell, Jimmy D. and Williams, Steve C. and Bates, Timothy E. and Abel, Paul D. and Foster, Christopher S. (1994) Effect of fish oil on cancer cachexia and host liver metabolism in rats with prostate tumors. Lipids, 29 (3). pp. 195-203. ISSN 0024-4201

Murphy, Elizabeth J. and Bates, Timothy E. and Williams, Stephen R. and Watson, Tracey and Brindle, Kevin M. and Rajagopalan, Bheeshma and Radda, George K. (1992) Endoplasmic reticulum: the major contributor to the PDE peak in hepatic 31P-NMR spectra at low magnetic field strengths. Biochimica et biophysica acta: biomembranes, 1111 (1). pp. 51-58. ISSN 0005-2736

AEA

Athanasiou, Andriani and Clarke, Anna B. and Turner, Amy E. and Kumaran, Nethia M. and Vakilpour, Sara and Smith, Paul A. and Bagiokou, Dimitra and Bradshaw, Tracey D. and Westwell, Andrew D. and Fang, Lin and Lobo, Dileep N. and Constantinescu, Cris S. and Calabrese, Vittorio and Loesch, Andrzej and Alexander, Stephen P. H. and Clothier, Richard H. and Kendall, David A. and Bates, Timothy E. (2007) Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications, 364 (1). pp. 131-137. ISSN 0006-291x

AMPA

Rosin, Claudia and Bates, Timothy E. and Skaper, Stephen D. (2004) Excitatory amino acid induced oligodendrocyte cell death in vitro: receptor-dependent and -independent mechanisms. Journal of Neurochemistry, 90 (5). pp. 1173-1185. ISSN 0022-3042

ATP

Allen, Kathryn L. and Almeida, Angeles and Bates, Timothy E. and Clark, John B. (1995) Changes of respiratory chain activity in mitochondrial and synaptosomal fractions isolated from the gerbil brain after graded ischaemia. Journal of neurochemistry, 64 (5). pp. 2222-2229. ISSN 0022-3042

Bates, T. E. and Heales, S. J. and Davies, S. E. and Boakye, P. and Clark, J. B. (1994) Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. Journal of neurochemistry, 63 (2). pp. 640-648. ISSN 0022-3042

Age

Tew, G. and Klonizakis, Markos and Moss, J. and Ruddock, A. D. and Saxton, J. M. and Hodges, G. J. (2011) Reproducibility of cutaneous thermal hyperaemia assessed by laser Doppler flowmetry in young and older adults. Microvascular Research, 81 (2). pp. 177-182. ISSN 0026-2862

Ageing

Tew, G. and Klonizakis, Markos and Saxton, G. (2010) Effects of ageing and fitness on skin-microvessel vasodilator function in humans. European Journal of Applied Physiology, 109 (2). pp. 173-181. ISSN 1439-6319

Alzheimer's

Mancuso, Cesare and Bates, Timothy E. and Butterfield, D. Allan and Calafato, Stella and Cornelius, Carolin and De Lorenzo, Antonino and Dinkova Kostova, Albena T. and Calabrese, Vittorio (2007) Natural antioxidants in Alzheimer's disease. Expert Opinion on Investigational Drugs, 16 (12). pp. 1921-1931. ISSN 1354-3784

Pardon, Marie-Christine and Sarmad, Sarir and Rattray, Ivan and Bates, Timothy E. and Scullion, Gillian A. and Marsden, Charles A. and Barrett, David A. and Lowe, James and Kendall, David A. (2009) Repeated novel cage exposure-induced improvement of early Alzheimer's-like cognitive and amyloid changes in TASTPM mice is unrelated to changes in brain endocannabinoids levels. Neurobiology of Aging, 30 (7). pp. 1099-1113. ISSN 0197-4580

Antioxidant

Calabrese, V. and Bates, T. E. and Stella, A. M. (2000) NO synthase and NO-dependent signal pathways in brain aging and neurodegenerative disorders: the role of oxidant/antioxidant balance. Neurochemical Research, 25 (9-10). pp. 1315-41. ISSN 0364-3190

Calabrese, V. and Scapagnini, G. and Catalano, C. and Bates, T. E. and Dinotta, F. and Micali, G. and Giuffrida Stella, A. M. (2001) Induction of heat shock protein synthesis in human skin fibroblasts in response to oxidative stress: regulation by a natural antioxidant from rosemary extract. International Journal of Tissue Reactions, 23 (2). pp. 51-8. ISSN 0250-0868

Antioxidants

Mancuso, Cesare and Bates, Timothy E. and Butterfield, D. Allan and Calafato, Stella and Cornelius, Carolin and De Lorenzo, Antonino and Dinkova Kostova, Albena T. and Calabrese, Vittorio (2007) Natural antioxidants in Alzheimer's disease. Expert Opinion on Investigational Drugs, 16 (12). pp. 1921-1931. ISSN 1354-3784

BAY 57-1293

Biswas, Subhajit and Núñez Miguel, Ricardo and Sukla, Soumi and Field, Hugh J. (2009) A mutation in helicase motif IV of herpes simplex virus type 1 UL5 that results in reduced growth in vitro and lower virulence in a murine infection model is related to the predicted helicase structure. Journal of General Virology, 90 (8). pp. 1937-1942. ISSN 0022-1317

BSO

Heales, S. J. and Davies, S. E. and Bates, T. E. and Clark, J. B. (1995) Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration. Neurochemical research, 20 (1). pp. 31-38. ISSN 0364-3190

BV2

Moss, David W. and Bates, Timothy E. (2001) Activation of murine microglial cell lines by lipopolysaccharide and interferon-gamma causes NO-mediated decreases in mitochondrial and cellular function. The European Journal of Neuroscience, 13 (3). pp. 529-38. ISSN 0953-816X

Brain

Allen, Kathryn L. and Almeida, Angeles and Bates, Timothy E. and Clark, John B. (1995) Changes of respiratory chain activity in mitochondrial and synaptosomal fractions isolated from the gerbil brain after graded ischaemia. Journal of neurochemistry, 64 (5). pp. 2222-2229. ISSN 0022-3042

Almeida, A. and Brooks, K. J. and Sammut, I. and Keelan, J. and Davey, G. P. and Clark, J. B. and Bates, T. E. (1995) Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain. Developmental neuroscience, 17 (4). pp. 212-218. ISSN 0378-5866

Bakken, Inger J. and Sonnewald, Ursula and Clark, John B. and Bates, Timothy E. (1997) [U-13C]glutamate metabolism in rat brain mitochondria reveals malic enzyme activity. Neuroreport, 8 (7). pp. 1567-1570. ISSN 0959-4965

Bates, T. E and Loesch, A. and Burnstock, G. and Clark, J. B. (1995) Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver. Biochemical and biophysical research communications, 213 (3). pp. 896-900. ISSN 0006-291X

Bates, T. E. and Heales, S. J. and Davies, S. E. and Boakye, P. and Clark, J. B. (1994) Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. Journal of neurochemistry, 63 (2). pp. 640-648. ISSN 0022-3042

Bates, Timothy E. and Strangward, Maria and Keelan, Julia and Davey, Gavin P. and Munro, Peter M. G. and Clark, John B. (1996) Inhibition of N-acetylaspartate production: implications for 1H MRS studies in vivo. Neuroreport, 7 (8). pp. 1397-1400. ISSN 0959-4965

Heales, S. J. and Davies, S. E. and Bates, T. E. and Clark, J. B. (1995) Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration. Neurochemical research, 20 (1). pp. 31-38. ISSN 0364-3190

Keelan, Julie and Bates, Timothy E. and Clark, John B. (1996) Intrasynaptosomal free calcium concentration during rat brain development: effects of hypoxia, aglycaemia, and ischaemia. Journal of neurochemistry, 66 (6). pp. 2460-7. ISSN 0022-3042

Brain Slices

Brooks, Keith J. and Hargreaves, Iain P. and Bates, Timothy E. (2008) Protection of respiratory chain enzymes from ischaemic damage in adult rat brain slices. Neurochemical research, 33 (9). pp. 1711-1716. ISSN 0364-3190

Brain Tumour

Levicar, Natasa and Dewey, Ricardo A. and Daley, Emma and Bates, Timothy E. and Davies, Derek and Kos, Janko and Pilkington, Geoffrey J. and Lah, Tamara T. (2003) Selective suppression of cathepsin L by antisense cDNA impairs human brain tumor cell invasion in vitro and promotes apoptosis. Cancer Gene Therapy, 10 (2). pp. 141-51. ISSN 0929-1903

Ca2+

Keelan, Julie and Bates, Timothy E. and Clark, John B. (1996) Intrasynaptosomal free calcium concentration during rat brain development: effects of hypoxia, aglycaemia, and ischaemia. Journal of neurochemistry, 66 (6). pp. 2460-7. ISSN 0022-3042

Calcium

Keelan, Julie and Bates, Timothy E. and Clark, John B. (1996) Intrasynaptosomal free calcium concentration during rat brain development: effects of hypoxia, aglycaemia, and ischaemia. Journal of neurochemistry, 66 (6). pp. 2460-7. ISSN 0022-3042

Cancer

Dagnelie, Pieter C. and Bell, Jimmy D. and Williams, Steve C. and Bates, Timothy E. and Abel, Paul D. and Foster, Christopher S. (1994) Effect of fish oil on cancer cachexia and host liver metabolism in rats with prostate tumors. Lipids, 29 (3). pp. 195-203. ISSN 0024-4201

Cathepsin

Levicar, Natasa and Dewey, Ricardo A. and Daley, Emma and Bates, Timothy E. and Davies, Derek and Kos, Janko and Pilkington, Geoffrey J. and Lah, Tamara T. (2003) Selective suppression of cathepsin L by antisense cDNA impairs human brain tumor cell invasion in vitro and promotes apoptosis. Cancer Gene Therapy, 10 (2). pp. 141-51. ISSN 0929-1903

Cellular stress response

Calabrese, Vittorio and Cornelius, Carolin and Mancuso, Cesare and Pennisi, Giovanni and Calafato, Stella and Bellia, Francesco and Bates, Timothy E. and Giuffrida Stella, Anna Maria and Schapira, Tony and Dinkova Kostova, Albena T. and Rizzarelli, Enrico (2008) Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity. Neurochemical Research, 33 (12). pp. 2444-2471. ISSN 0364-3190

Clinical application

Klonizakis, Markos and Manning, Gillian and Donnelly, Richard (2011) Assessment of lower limb microcirculation: exploring the reproducibility and clinical application of laser doppler techniques. Skin Pharmacology and Physiology: Journal of Pharmacological and Biophysical Research, 24 (3). pp. 136-143. ISSN 1660-5527

Complex I

Bates, T. E. and Heales, S. J. and Davies, S. E. and Boakye, P. and Clark, J. B. (1994) Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. Journal of neurochemistry, 63 (2). pp. 640-648. ISSN 0022-3042

Complexes

Heales, S. J. and Davies, S. E. and Bates, T. E. and Clark, J. B. (1995) Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration. Neurochemical research, 20 (1). pp. 31-38. ISSN 0364-3190

D2 receptor

Rosin, Claudia and Colombo, Sergio and Calver, Andrew A. and Bates, Timothy E. and Skaper, Stephen D. (2005) Dopamine D2 and D3 receptor agonists limit oligodendrocyte injury caused by glutamate oxidative stress and oxygen/glucose deprivation. Glia, 52 (4). pp. 336-343. ISSN 0894-1491

D3 receptor

Rosin, Claudia and Colombo, Sergio and Calver, Andrew A. and Bates, Timothy E. and Skaper, Stephen D. (2005) Dopamine D2 and D3 receptor agonists limit oligodendrocyte injury caused by glutamate oxidative stress and oxygen/glucose deprivation. Glia, 52 (4). pp. 336-343. ISSN 0894-1491

Delta-9-tetrahydrocannabinol

Athanasiou, Andriani and Clarke, Anna B. and Turner, Amy E. and Kumaran, Nethia M. and Vakilpour, Sara and Smith, Paul A. and Bagiokou, Dimitra and Bradshaw, Tracey D. and Westwell, Andrew D. and Fang, Lin and Lobo, Dileep N. and Constantinescu, Cris S. and Calabrese, Vittorio and Loesch, Andrzej and Alexander, Stephen P. H. and Clothier, Richard H. and Kendall, David A. and Bates, Timothy E. (2007) Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications, 364 (1). pp. 131-137. ISSN 0006-291x

Development

Almeida, A. and Brooks, K. J. and Sammut, I. and Keelan, J. and Davey, G. P. and Clark, J. B. and Bates, T. E. (1995) Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain. Developmental neuroscience, 17 (4). pp. 212-218. ISSN 0378-5866

Keelan, Julie and Bates, Timothy E. and Clark, John B. (1996) Intrasynaptosomal free calcium concentration during rat brain development: effects of hypoxia, aglycaemia, and ischaemia. Journal of neurochemistry, 66 (6). pp. 2460-7. ISSN 0022-3042

Dietary antioxidants

Calabrese, V. and Bates, T. E. and Stella, A. M. (2000) NO synthase and NO-dependent signal pathways in brain aging and neurodegenerative disorders: the role of oxidant/antioxidant balance. Neurochemical Research, 25 (9-10). pp. 1315-41. ISSN 0364-3190

EM

Bates, T. E. and Loesch, A. and Burnstock, G. and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochemical and biophysical research communications, 218 (1). pp. 40-44. ISSN 0006-291X

Electron Microscopy

Bates, T. E. and Loesch, A. and Burnstock, G. and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochemical and biophysical research communications, 218 (1). pp. 40-44. ISSN 0006-291X

Electron Transport Chain

Allen, Kathryn L. and Almeida, Angeles and Bates, Timothy E. and Clark, John B. (1995) Changes of respiratory chain activity in mitochondrial and synaptosomal fractions isolated from the gerbil brain after graded ischaemia. Journal of neurochemistry, 64 (5). pp. 2222-2229. ISSN 0022-3042

Almeida, A. and Brooks, K. J. and Sammut, I. and Keelan, J. and Davey, G. P. and Clark, J. B. and Bates, T. E. (1995) Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain. Developmental neuroscience, 17 (4). pp. 212-218. ISSN 0378-5866

Almeida, A. and Brooks, K. J. and Sammut, I. and Keelan, J. and Davey, G. P. and Clark, J. B. and Bates, T. E. (1995) Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain. Developmental Neuroscience, 17 (4). pp. 212-218. ISSN 0378-5866

Almeida, Angeles and Allen, Kathryn L. and Bates, TImothy E. and Clark, John B. (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. Journal of neurochemistry, 65 (4). pp. 1698-1703. ISSN 0022-3042

Endothelial function

Klonizakis, Markos and Manning, Gillian and Donnelly, Richard (2011) Assessment of lower limb microcirculation: exploring the reproducibility and clinical application of laser doppler techniques. Skin Pharmacology and Physiology: Journal of Pharmacological and Biophysical Research, 24 (3). pp. 136-143. ISSN 1660-5527

Exercise

Tew, G. and Klonizakis, Markos and Saxton, G. (2010) Effects of ageing and fitness on skin-microvessel vasodilator function in humans. European Journal of Applied Physiology, 109 (2). pp. 173-181. ISSN 1439-6319

Fatty acide ethyl esters

Calabrese, V. and Scapagnini, G. and Catalano, C. and Dinotta, F. and Bates, T. E. and Calvani, M. and Stella, A. M. (2001) Effects of acetyl-L-carnitine on the formation of fatty acid ethyl esters in brain and peripheral organs after short-term ethanol administration in rat. Neurochemical Research, 26 (2). pp. 167-74. ISSN 0364-3190

GSH

Brooks, Keith J and Hargreaves, Iain and Bhakoo, Kishore and Sellwood, Mark and O'Brien, Francis and Noone, Martina and Sakata, Yasuko and Cady, Ernest and Wylezinska, Marzena and Thornton, John and Ordidge, Roger and Nguyen, Quyen and Clemence, Matthew and Wyatt, John and Bates, Timothy E. (2002) Delayed hypothermia prevents decreases in N-acetylaspartate and reduced glutathione in the cerebral cortex of the neonatal pig following transient hypoxia-ischaemia. Neurochemical Research, 27 (12). pp. 1599-604. ISSN 0364-3190

Calabrese, Vittorio and Testa, Guiseppe and Ravagna, Agrippino and Bates, Timothy Edward and Stella, Anna Maria (2000) HSP70 induction in the brain following ethanol administration in the rat: regulation by glutathione redox state. Biochemical and Biophysical Research Communications, 269 (2). pp. 397-400. ISSN 0006-291X

Heales, S. J. and Davies, S. E. and Bates, T. E. and Clark, J. B. (1995) Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration. Neurochemical research, 20 (1). pp. 31-38. ISSN 0364-3190

Kenyon, Susan H. and Waterfield, Catherine J. and Asker, Daniel S. and Kudo, Mariko and Moss, David W. and Bates, Timothy E. and Nicolaou, Anna and Gibbons, William A. and Timbrell, John A. (1999) Effect of hydrazine upon vitamin B12-dependent methionine synthase activity and the sulphur amino acid pathway in isolated rat hepatocytes. Biochemical Pharmacology, 57 (11). pp. 1311-1319. ISSN 0006-2952

Gerbil

Canevari, Laura and Console, Antonella and Tendi, E. A. and Clark, J. B. and Bates, Timothy (1999) Effect of postischaemic hypothermia on the mitochondrial damage induced by ischaemia and reperfusion in the gerbil. Brain research, 817 (1-2). pp. 241-245. ISSN 0006-8993

Glutamate receptors

Rosin, Claudia and Bates, Timothy E. and Skaper, Stephen D. (2004) Excitatory amino acid induced oligodendrocyte cell death in vitro: receptor-dependent and -independent mechanisms. Journal of Neurochemistry, 90 (5). pp. 1173-1185. ISSN 0022-3042

Glutathione

Calabrese, Vittorio and Scapagnini, Giovanni and Ravagna, Agrippino and Bella, Rita and Foresti, Roberta and Bates, Timothy E. and Giuffrida Stella, Anna-Maria and Pennisi, Giovanni (2002) Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels. Journal of Neuroscience Research, 70 (4). pp. 580-7. ISSN 0360-4012

Heales, S. J. and Davies, S. E. and Bates, T. E. and Clark, J. B. (1995) Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration. Neurochemical research, 20 (1). pp. 31-38. ISSN 0364-3190

H202

Bates, T. E. and Heales, S. J. and Davies, S. E. and Boakye, P. and Clark, J. B. (1994) Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. Journal of neurochemistry, 63 (2). pp. 640-648. ISSN 0022-3042

H460

Athanasiou, Andriani and Clarke, Anna B. and Turner, Amy E. and Kumaran, Nethia M. and Vakilpour, Sara and Smith, Paul A. and Bagiokou, Dimitra and Bradshaw, Tracey D. and Westwell, Andrew D. and Fang, Lin and Lobo, Dileep N. and Constantinescu, Cris S. and Calabrese, Vittorio and Loesch, Andrzej and Alexander, Stephen P. H. and Clothier, Richard H. and Kendall, David A. and Bates, Timothy E. (2007) Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications, 364 (1). pp. 131-137. ISSN 0006-291x

Athanasiou, Andriani and Smith, Paul A. and Vakilpour, Sara and Kumaran, Nethia M. and Turner, Amy E. and Bagiokou, Dimitra and Layfield, Robert and Ray, David E. and Westwell, Andrew D. and Alexander, Stephen P. H. and Kendall, David A. and Lobo, Dileep N. and Watson, Susan A. and Lophatanon, Artitaya and Muir, Kenneth A. and Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

HSP 70

Calabrese, Vittorio and Testa, Guiseppe and Ravagna, Agrippino and Bates, Timothy Edward and Stella, Anna Maria (2000) HSP70 induction in the brain following ethanol administration in the rat: regulation by glutathione redox state. Biochemical and Biophysical Research Communications, 269 (2). pp. 397-400. ISSN 0006-291X

HSP's

Calabrese, V. and Scapagnini, G. and Catalano, C. and Bates, T. E. and Geraci, D. and Pennisi, G. and Giuffrida Stella, A. M. (2001) Regulation of heat shock protein synthesis in human skin fibroblasts in response to oxidative stress: role of vitamin E. International Journal of Tissue Reactions, 23 (4). pp. 127-35. ISSN 0250-0868

HU 210

Athanasiou, Andriani and Clarke, Anna B. and Turner, Amy E. and Kumaran, Nethia M. and Vakilpour, Sara and Smith, Paul A. and Bagiokou, Dimitra and Bradshaw, Tracey D. and Westwell, Andrew D. and Fang, Lin and Lobo, Dileep N. and Constantinescu, Cris S. and Calabrese, Vittorio and Loesch, Andrzej and Alexander, Stephen P. H. and Clothier, Richard H. and Kendall, David A. and Bates, Timothy E. (2007) Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications, 364 (1). pp. 131-137. ISSN 0006-291x

Heart

Bates, T. E. and Loesch, A. and Burnstock, G. and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochemical and biophysical research communications, 218 (1). pp. 40-44. ISSN 0006-291X

Sammut, Ivan A. and Jayakumar, Jay and Latif, Najmi and Rothery, Stephen and Severs, Nicholas J. and Smolenski, Ryszard T. and Bates, Timothy E. and Yacoub, Magdi H. (2001) Heat stress contributes to the enhancement of cardiac mitochondrial complex activity. The American Journal of Pathology, 158 (5). pp. 1821-31. ISSN 0002-9440

Heat

Tew, G. and Klonizakis, Markos and Moss, J. and Ruddock, A. D. and Saxton, J. M. and Hodges, G. J. (2011) Reproducibility of cutaneous thermal hyperaemia assessed by laser Doppler flowmetry in young and older adults. Microvascular Research, 81 (2). pp. 177-182. ISSN 0026-2862

Heat Shock

Calabrese, V. and Scapagnini, G. and Catalano, C. and Bates, T. E. and Dinotta, F. and Micali, G. and Giuffrida Stella, A. M. (2001) Induction of heat shock protein synthesis in human skin fibroblasts in response to oxidative stress: regulation by a natural antioxidant from rosemary extract. International Journal of Tissue Reactions, 23 (2). pp. 51-8. ISSN 0250-0868

Calabrese, V. and Scapagnini, G. and Catalano, C. and Bates, T. E. and Geraci, D. and Pennisi, G. and Giuffrida Stella, A. M. (2001) Regulation of heat shock protein synthesis in human skin fibroblasts in response to oxidative stress: role of vitamin E. International Journal of Tissue Reactions, 23 (4). pp. 127-35. ISSN 0250-0868

Sammut, Ivan A. and Jayakumar, Jay and Latif, Najmi and Rothery, Stephen and Severs, Nicholas J. and Smolenski, Ryszard T. and Bates, Timothy E. and Yacoub, Magdi H. (2001) Heat stress contributes to the enhancement of cardiac mitochondrial complex activity. The American Journal of Pathology, 158 (5). pp. 1821-31. ISSN 0002-9440

Hepatocytes

Kenyon, Susan H. and Waterfield, Catherine J. and Asker, Daniel S. and Kudo, Mariko and Moss, David W. and Bates, Timothy E. and Nicolaou, Anna and Gibbons, William A. and Timbrell, John A. (1999) Effect of hydrazine upon vitamin B12-dependent methionine synthase activity and the sulphur amino acid pathway in isolated rat hepatocytes. Biochemical Pharmacology, 57 (11). pp. 1311-1319. ISSN 0006-2952

Hydrogen peroxide

Bates, T. E. and Heales, S. J. and Davies, S. E. and Boakye, P. and Clark, J. B. (1994) Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. Journal of neurochemistry, 63 (2). pp. 640-648. ISSN 0022-3042

Hypothermia

Canevari, Laura and Console, Antonella and Tendi, E. A. and Clark, J. B. and Bates, Timothy (1999) Effect of postischaemic hypothermia on the mitochondrial damage induced by ischaemia and reperfusion in the gerbil. Brain research, 817 (1-2). pp. 241-245. ISSN 0006-8993

IPTP

Levicar, Natasa and Dewey, Ricardo A. and Daley, Emma and Bates, Timothy E. and Davies, Derek and Kos, Janko and Pilkington, Geoffrey J. and Lah, Tamara T. (2003) Selective suppression of cathepsin L by antisense cDNA impairs human brain tumor cell invasion in vitro and promotes apoptosis. Cancer Gene Therapy, 10 (2). pp. 141-51. ISSN 0929-1903

Immumnoelectron microscopy

Bates, T. E. and Loesch, A. and Burnstock, G. and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochemical and biophysical research communications, 218 (1). pp. 40-44. ISSN 0006-291X

Immunocytochemistry

Bates, T. E. and Loesch, A. and Burnstock, G. and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochemical and biophysical research communications, 218 (1). pp. 40-44. ISSN 0006-291X

Interferon gamma

Moss, David W. and Bates, Timothy E. (2001) Activation of murine microglial cell lines by lipopolysaccharide and interferon-gamma causes NO-mediated decreases in mitochondrial and cellular function. The European Journal of Neuroscience, 13 (3). pp. 529-38. ISSN 0953-816X

Iontophoresis

Klonizakis, Markos and Manning, Gillian and Donnelly, Richard (2011) Assessment of lower limb microcirculation: exploring the reproducibility and clinical application of laser doppler techniques. Skin Pharmacology and Physiology: Journal of Pharmacological and Biophysical Research, 24 (3). pp. 136-143. ISSN 1660-5527

Ischaemia

Allen, Kathryn L. and Almeida, Angeles and Bates, Timothy E. and Clark, John B. (1995) Changes of respiratory chain activity in mitochondrial and synaptosomal fractions isolated from the gerbil brain after graded ischaemia. Journal of neurochemistry, 64 (5). pp. 2222-2229. ISSN 0022-3042

Almeida, Angeles and Allen, Kathryn L. and Bates, TImothy E. and Clark, John B. (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. Journal of neurochemistry, 65 (4). pp. 1698-1703. ISSN 0022-3042

Brooks, Keith J. and Hargreaves, Iain P. and Bates, Timothy E. (2008) Protection of respiratory chain enzymes from ischaemic damage in adult rat brain slices. Neurochemical research, 33 (9). pp. 1711-1716. ISSN 0364-3190

Ischemia

Allen, Kathryn L. and Almeida, Angeles and Bates, Timothy E. and Clark, John B. (1995) Changes of respiratory chain activity in mitochondrial and synaptosomal fractions isolated from the gerbil brain after graded ischaemia. Journal of neurochemistry, 64 (5). pp. 2222-2229. ISSN 0022-3042

Almeida, Angeles and Allen, Kathryn L. and Bates, TImothy E. and Clark, John B. (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. Journal of neurochemistry, 65 (4). pp. 1698-1703. ISSN 0022-3042

Brooks, Keith J and Hargreaves, Iain and Bhakoo, Kishore and Sellwood, Mark and O'Brien, Francis and Noone, Martina and Sakata, Yasuko and Cady, Ernest and Wylezinska, Marzena and Thornton, John and Ordidge, Roger and Nguyen, Quyen and Clemence, Matthew and Wyatt, John and Bates, Timothy E. (2002) Delayed hypothermia prevents decreases in N-acetylaspartate and reduced glutathione in the cerebral cortex of the neonatal pig following transient hypoxia-ischaemia. Neurochemical Research, 27 (12). pp. 1599-604. ISSN 0364-3190

Brooks, Keith J. and Hargreaves, Iain P. and Bates, Timothy E. (2008) Protection of respiratory chain enzymes from ischaemic damage in adult rat brain slices. Neurochemical research, 33 (9). pp. 1711-1716. ISSN 0364-3190

Kuroda, Satoshi and Katsura, Ken-ichiro and Hillered, Lars and Bates, Timothy E. and Siesjö, Bo K. (1996) Delayed treatment with alpha-phenyl-N-tert-butyl nitrone (PBN) attenuates secondary mitochondrial dysfunction after transient focal cerebral ischemia in the rat. Neurobiology of Disease, 3 (2). pp. 149-157. ISSN 0969-9961

J774

Moss, David W. and Bates, Timothy E. (2001) Activation of murine microglial cell lines by lipopolysaccharide and interferon-gamma causes NO-mediated decreases in mitochondrial and cellular function. The European Journal of Neuroscience, 13 (3). pp. 529-38. ISSN 0953-816X

Kidney

Bates, T. E. and Loesch, A. and Burnstock, G. and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochemical and biophysical research communications, 218 (1). pp. 40-44. ISSN 0006-291X

L-buthionine sulfoximine

Heales, S. J. and Davies, S. E. and Bates, T. E. and Clark, J. B. (1995) Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration. Neurochemical research, 20 (1). pp. 31-38. ISSN 0364-3190

LASCA

Tew, Garry A. and Klonizakis, Markos and Crank, Helen and Briers, J. David and Hodges, Gary J. (2011) Comparison of laser speckle contrast imaging with laser Doppler for assessing microvascular function. Microvascular Research, 82 (3). pp. 326-332. ISSN 0026-2862

LDF

Tew, G. and Klonizakis, Markos and Moss, J. and Ruddock, A. D. and Saxton, J. M. and Hodges, G. J. (2011) Role of sensory nerves in the rapid cutaneous vasodilator response to local heating in young and older endurance-trained and untrained men. Experimental Physiology, 96 (2). pp. 163-170. ISSN 0958-0670

LPS

Moss, David W. and Bates, Timothy E. (2001) Activation of murine microglial cell lines by lipopolysaccharide and interferon-gamma causes NO-mediated decreases in mitochondrial and cellular function. The European Journal of Neuroscience, 13 (3). pp. 529-38. ISSN 0953-816X

Laser Doppler flowmetry

Tew, G. and Klonizakis, Markos and Moss, J. and Ruddock, A. D. and Saxton, J. M. and Hodges, G. J. (2011) Reproducibility of cutaneous thermal hyperaemia assessed by laser Doppler flowmetry in young and older adults. Microvascular Research, 81 (2). pp. 177-182. ISSN 0026-2862

Tew, G. and Klonizakis, Markos and Moss, J. and Ruddock, A. and Saxton, J. M. and Hodges, G. (2010) Role of sensory nerves in the rapid cutaneous vasodilator response to local heating in young and older endurance-trained and untrained men. In: 9th World Congress on Microcirculation, 26 - 28 September 2010, Maison de la Chimie, Paris.

Tew, G. and Klonizakis, Markos and Saxton, G. (2010) Effects of ageing and fitness on skin-microvessel vasodilator function in humans. European Journal of Applied Physiology, 109 (2). pp. 173-181. ISSN 1439-6319

Laser Doppler fluximetry

Klonizakis, Markos and Manning, Gillian and Donnelly, Richard (2011) Assessment of lower limb microcirculation: exploring the reproducibility and clinical application of laser doppler techniques. Skin Pharmacology and Physiology: Journal of Pharmacological and Biophysical Research, 24 (3). pp. 136-143. ISSN 1660-5527

Lipopolysaccharide

Moss, David W. and Bates, Timothy E. (2001) Activation of murine microglial cell lines by lipopolysaccharide and interferon-gamma causes NO-mediated decreases in mitochondrial and cellular function. The European Journal of Neuroscience, 13 (3). pp. 529-38. ISSN 0953-816X

Liver

Bates, T. E and Loesch, A. and Burnstock, G. and Clark, J. B. (1995) Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver. Biochemical and biophysical research communications, 213 (3). pp. 896-900. ISSN 0006-291X

Dagnelie, P. C. and Bell, J. D. and Williams, S. C. and Bates, T. E. and Abel, P. D. and Foster, C. S. (1993) Altered phosphorylation status, phospholipid metabolism and gluconeogenesis in the host liver of rats with prostate cancer: a 31P magnetic resonance spectroscopy study. British Journal of Cancer, 67 (6). pp. 1303-1309. ISSN 0007-0920

Murphy, Elizabeth J. and Bates, Timothy E. and Williams, Stephen R. and Watson, Tracey and Brindle, Kevin M. and Rajagopalan, Bheeshma and Radda, George K. (1992) Endoplasmic reticulum: the major contributor to the PDE peak in hepatic 31P-NMR spectra at low magnetic field strengths. Biochimica et biophysica acta: biomembranes, 1111 (1). pp. 51-58. ISSN 0005-2736

Sammut, Ivan A. and Thorniley, Maureen S. and Simpkin, Sandra and Fuller, Barry J. and Bates, Timothy E. and Green, Colin J. (1998) Impairment of hepatic mitochondrial respiratory function following storage and orthotopic transplantation of rat livers. Cryobiology, 36 (1). pp. 49-60. ISSN 0011-2240

MCAO

Canevari, Laura and Kuroda, Satoshi and Bates, Timothy E. and Clark, John B. and Siesjö, Bo K. (1997) Activity of mitochondrial respiratory chain enzymes after transient focal ischemia in the rat. Journal of Cerebral Blood Flow and Metabolism : official Journal of the International Society of Cerebral Blood Flow and Metabolism, 17 (11). pp. 1166-9. ISSN 0271-678X

MPP+

Bates, T. E. and Heales, S. J. and Davies, S. E. and Boakye, P. and Clark, J. B. (1994) Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. Journal of neurochemistry, 63 (2). pp. 640-648. ISSN 0022-3042

MPT Pore

Kristián, Tibor and Gertsch, Jeff and Bates, Timothy E. and Siesjö, Bo K. (2000) Characteristics of the calcium-triggered mitochondrial permeability transition in nonsynaptic brain mitochondria: effect of cyclosporin A and ubiquinone O. Journal of Neurochemistry, 74 (5). pp. 1999-2009. ISSN 0022-3042

MPTP

Bates, T. E. and Heales, S. J. and Davies, S. E. and Boakye, P. and Clark, J. B. (1994) Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. Journal of neurochemistry, 63 (2). pp. 640-648. ISSN 0022-3042

MRS

Bates, Timothy E. and Strangward, Maria and Keelan, Julia and Davey, Gavin P. and Munro, Peter M. G. and Clark, John B. (1996) Inhibition of N-acetylaspartate production: implications for 1H MRS studies in vivo. Neuroreport, 7 (8). pp. 1397-1400. ISSN 0959-4965

Dagnelie, P. C. and Bell, J. D. and Williams, S. C. and Bates, T. E. and Abel, P. D. and Foster, C. S. (1993) Altered phosphorylation status, phospholipid metabolism and gluconeogenesis in the host liver of rats with prostate cancer: a 31P magnetic resonance spectroscopy study. British Journal of Cancer, 67 (6). pp. 1303-1309. ISSN 0007-0920

Dagnelie, Pieter C. and Bell, Jimmy D. and Williams, Steve C. and Bates, Timothy E. and Abel, Paul D. and Foster, Christopher S. (1994) Effect of fish oil on cancer cachexia and host liver metabolism in rats with prostate tumors. Lipids, 29 (3). pp. 195-203. ISSN 0024-4201

Microvascular perfusion

Klonizakis, Markos and Manning, Gillian and Donnelly, Richard (2011) Assessment of lower limb microcirculation: exploring the reproducibility and clinical application of laser doppler techniques. Skin Pharmacology and Physiology: Journal of Pharmacological and Biophysical Research, 24 (3). pp. 136-143. ISSN 1660-5527

Mitochondria

Allen, Kathryn L. and Almeida, Angeles and Bates, Timothy E. and Clark, John B. (1995) Changes of respiratory chain activity in mitochondrial and synaptosomal fractions isolated from the gerbil brain after graded ischaemia. Journal of neurochemistry, 64 (5). pp. 2222-2229. ISSN 0022-3042

Almeida, A. and Brooks, K. J. and Sammut, I. and Keelan, J. and Davey, G. P. and Clark, J. B. and Bates, T. E. (1995) Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain. Developmental neuroscience, 17 (4). pp. 212-218. ISSN 0378-5866

Almeida, Angeles and Allen, Kathryn L. and Bates, TImothy E. and Clark, John B. (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. Journal of neurochemistry, 65 (4). pp. 1698-1703. ISSN 0022-3042

Bates, T. E and Loesch, A. and Burnstock, G. and Clark, J. B. (1995) Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver. Biochemical and biophysical research communications, 213 (3). pp. 896-900. ISSN 0006-291X

Bates, T. E. and Heales, S. J. and Davies, S. E. and Boakye, P. and Clark, J. B. (1994) Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. Journal of neurochemistry, 63 (2). pp. 640-648. ISSN 0022-3042

Bates, Timothy E. and Strangward, Maria and Keelan, Julia and Davey, Gavin P. and Munro, Peter M. G. and Clark, John B. (1996) Inhibition of N-acetylaspartate production: implications for 1H MRS studies in vivo. Neuroreport, 7 (8). pp. 1397-1400. ISSN 0959-4965

Brooks, Keith J. and Hargreaves, Iain P. and Bates, Timothy E. (2008) Protection of respiratory chain enzymes from ischaemic damage in adult rat brain slices. Neurochemical research, 33 (9). pp. 1711-1716. ISSN 0364-3190

Canevari, Laura and Clark, John B. and Bates, Timothy E. (1999) Beta-amyloid fragment 25-35 selectively decreases complex IV activity in isolated mitochondria. FEBS Letters, 457 (1). pp. 131-4. ISSN 0014-5793

Heales, S. J. and Davies, S. E. and Bates, T. E. and Clark, J. B. (1995) Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration. Neurochemical research, 20 (1). pp. 31-38. ISSN 0364-3190

Sammut, Ivan A. and Thorniley, Maureen S. and Simpkin, Sandra and Fuller, Barry J. and Bates, Timothy E. and Green, Colin J. (1998) Impairment of hepatic mitochondrial respiratory function following storage and orthotopic transplantation of rat livers. Cryobiology, 36 (1). pp. 49-60. ISSN 0011-2240

Mitochondrial complexes

Canevari, Laura and Kuroda, Satoshi and Bates, Timothy E. and Clark, John B. and Siesjö, Bo K. (1997) Activity of mitochondrial respiratory chain enzymes after transient focal ischemia in the rat. Journal of Cerebral Blood Flow and Metabolism : official Journal of the International Society of Cerebral Blood Flow and Metabolism, 17 (11). pp. 1166-9. ISSN 0271-678X

Sammut, Ivan A. and Thorniley, Maureen S. and Simpkin, Sandra and Fuller, Barry J. and Bates, Timothy E. and Green, Colin J. (1998) Impairment of hepatic mitochondrial respiratory function following storage and orthotopic transplantation of rat livers. Cryobiology, 36 (1). pp. 49-60. ISSN 0011-2240

N omega-nitro-L-arginine

Brooks, Keith J. and Hargreaves, Iain P. and Bates, Timothy E. (2008) Protection of respiratory chain enzymes from ischaemic damage in adult rat brain slices. Neurochemical research, 33 (9). pp. 1711-1716. ISSN 0364-3190

N-Acetylaspartate

Brooks, Keith J and Hargreaves, Iain and Bhakoo, Kishore and Sellwood, Mark and O'Brien, Francis and Noone, Martina and Sakata, Yasuko and Cady, Ernest and Wylezinska, Marzena and Thornton, John and Ordidge, Roger and Nguyen, Quyen and Clemence, Matthew and Wyatt, John and Bates, Timothy E. (2002) Delayed hypothermia prevents decreases in N-acetylaspartate and reduced glutathione in the cerebral cortex of the neonatal pig following transient hypoxia-ischaemia. Neurochemical Research, 27 (12). pp. 1599-604. ISSN 0364-3190

N-acetylaspartate

Bates, Timothy E. and Strangward, Maria and Keelan, Julia and Davey, Gavin P. and Munro, Peter M. G. and Clark, John B. (1996) Inhibition of N-acetylaspartate production: implications for 1H MRS studies in vivo. Neuroreport, 7 (8). pp. 1397-1400. ISSN 0959-4965

N11

Moss, David W. and Bates, Timothy E. (2001) Activation of murine microglial cell lines by lipopolysaccharide and interferon-gamma causes NO-mediated decreases in mitochondrial and cellular function. The European Journal of Neuroscience, 13 (3). pp. 529-38. ISSN 0953-816X

NAA

Brooks, Keith J and Hargreaves, Iain and Bhakoo, Kishore and Sellwood, Mark and O'Brien, Francis and Noone, Martina and Sakata, Yasuko and Cady, Ernest and Wylezinska, Marzena and Thornton, John and Ordidge, Roger and Nguyen, Quyen and Clemence, Matthew and Wyatt, John and Bates, Timothy E. (2002) Delayed hypothermia prevents decreases in N-acetylaspartate and reduced glutathione in the cerebral cortex of the neonatal pig following transient hypoxia-ischaemia. Neurochemical Research, 27 (12). pp. 1599-604. ISSN 0364-3190

NMR

Murphy, Elizabeth J. and Bates, Timothy E. and Williams, Stephen R. and Watson, Tracey and Brindle, Kevin M. and Rajagopalan, Bheeshma and Radda, George K. (1992) Endoplasmic reticulum: the major contributor to the PDE peak in hepatic 31P-NMR spectra at low magnetic field strengths. Biochimica et biophysica acta: biomembranes, 1111 (1). pp. 51-58. ISSN 0005-2736

NMR Spectroscopy

Bakken, Inger J. and Sonnewald, Ursula and Clark, John B. and Bates, Timothy E. (1997) [U-13C]glutamate metabolism in rat brain mitochondria reveals malic enzyme activity. Neuroreport, 8 (7). pp. 1567-1570. ISSN 0959-4965

Brooks, K. J. and Clark, J. B. and Bates, T. E. (1996) Assessment of energy metabolism in the developing brain following aglycemic hypoxia by 1H and 31P NMR. Neurochemical Research, 21 (9). pp. 1089-1095. ISSN 0364-3190

Gadian, D. G. and Williams, S. R. and Bates, T. E. and Kauppinen, R. A. (1993) NMR spectroscopy: current status and future possibilities. Acta neurochirurgica. Supplementum, 57 . pp. 1-8. ISSN 0065-1419

NMR spectroscopy

Dagnelie, P. C. and Bell, J. D. and Williams, S. C. and Bates, T. E. and Abel, P. D. and Foster, C. S. (1993) Altered phosphorylation status, phospholipid metabolism and gluconeogenesis in the host liver of rats with prostate cancer: a 31P magnetic resonance spectroscopy study. British Journal of Cancer, 67 (6). pp. 1303-1309. ISSN 0007-0920

Dagnelie, Pieter C. and Bell, Jimmy D. and Williams, Steve C. and Bates, Timothy E. and Abel, Paul D. and Foster, Christopher S. (1994) Effect of fish oil on cancer cachexia and host liver metabolism in rats with prostate tumors. Lipids, 29 (3). pp. 195-203. ISSN 0024-4201

NO

Calabrese, V. and Bates, T. E. and Stella, A. M. (2000) NO synthase and NO-dependent signal pathways in brain aging and neurodegenerative disorders: the role of oxidant/antioxidant balance. Neurochemical Research, 25 (9-10). pp. 1315-41. ISSN 0364-3190

Calabrese, Vittorio and Scapagnini, Giovanni and Ravagna, Agrippino and Bella, Rita and Foresti, Roberta and Bates, Timothy E. and Giuffrida Stella, Anna-Maria and Pennisi, Giovanni (2002) Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels. Journal of Neuroscience Research, 70 (4). pp. 580-7. ISSN 0360-4012

Cooper, Chris E. and Davies, Nathan A. and Psychoulis, Minas and Canevari, Laura and Bates, Tim E. and Dobbie, Michael S. and Casley, Christopher S. and Sharpe, Martyn A. (2003) Nitric oxide and peroxynitrite cause irreversible increases in the K(m) for oxygen of mitochondrial cytochrome oxidase: in vitro and in vivo studies. Biochimica et Biophysica Acta: general subjects, 1607 (1). pp. 27-34. ISSN 0006-3002

Keelan, J. and Brand, M. P. and Bates, T. E. and Land, J. M. and Clark, J. B. and Heales, S. J. (1996) Nitric oxide and antioxidant status in glucose and oxygen deprived neonatal and adult rat brain synaptosomes. Neurochemical Research, 21 (8). pp. 923-7. ISSN 0364-3190

Moss, David W. and Bates, Timothy E. (2001) Activation of murine microglial cell lines by lipopolysaccharide and interferon-gamma causes NO-mediated decreases in mitochondrial and cellular function. The European Journal of Neuroscience, 13 (3). pp. 529-38. ISSN 0953-816X

NOS

Bates, T. E and Loesch, A. and Burnstock, G. and Clark, J. B. (1995) Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver. Biochemical and biophysical research communications, 213 (3). pp. 896-900. ISSN 0006-291X

Bates, T. E. and Loesch, A. and Burnstock, G. and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochemical and biophysical research communications, 218 (1). pp. 40-44. ISSN 0006-291X

Calabrese, V. and Bates, T. E. and Stella, A. M. (2000) NO synthase and NO-dependent signal pathways in brain aging and neurodegenerative disorders: the role of oxidant/antioxidant balance. Neurochemical Research, 25 (9-10). pp. 1315-41. ISSN 0364-3190

Calabrese, Vittorio and Scapagnini, Giovanni and Ravagna, Agrippino and Bella, Rita and Foresti, Roberta and Bates, Timothy E. and Giuffrida Stella, Anna-Maria and Pennisi, Giovanni (2002) Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels. Journal of Neuroscience Research, 70 (4). pp. 580-7. ISSN 0360-4012

Moss, David W. and Bates, Timothy E. (2001) Activation of murine microglial cell lines by lipopolysaccharide and interferon-gamma causes NO-mediated decreases in mitochondrial and cellular function. The European Journal of Neuroscience, 13 (3). pp. 529-38. ISSN 0953-816X

Nitric Oxide Synthase

Bates, T. E and Loesch, A. and Burnstock, G. and Clark, J. B. (1995) Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver. Biochemical and biophysical research communications, 213 (3). pp. 896-900. ISSN 0006-291X

Bates, T. E. and Loesch, A. and Burnstock, G. and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochemical and biophysical research communications, 218 (1). pp. 40-44. ISSN 0006-291X

Brooks, K. J. and Hargreaves, I. P. and Bates, T. E. (2000) Nitric-oxide-induced inhibition of mitochondrial complexes following aglycaemic hypoxia in neonatal cortical rat brain slices. Developmental Neuroscience, 22 (5-6). pp. 359-65. ISSN 0378-5866

Calabrese, V. and Bates, T. E. and Stella, A. M. (2000) NO synthase and NO-dependent signal pathways in brain aging and neurodegenerative disorders: the role of oxidant/antioxidant balance. Neurochemical Research, 25 (9-10). pp. 1315-41. ISSN 0364-3190

Nitric oxide

Calabrese, Vittorio and Scapagnini, Giovanni and Ravagna, Agrippino and Bella, Rita and Foresti, Roberta and Bates, Timothy E. and Giuffrida Stella, Anna-Maria and Pennisi, Giovanni (2002) Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels. Journal of Neuroscience Research, 70 (4). pp. 580-7. ISSN 0360-4012

Cooper, Chris E. and Davies, Nathan A. and Psychoulis, Minas and Canevari, Laura and Bates, Tim E. and Dobbie, Michael S. and Casley, Christopher S. and Sharpe, Martyn A. (2003) Nitric oxide and peroxynitrite cause irreversible increases in the K(m) for oxygen of mitochondrial cytochrome oxidase: in vitro and in vivo studies. Biochimica et Biophysica Acta: general subjects, 1607 (1). pp. 27-34. ISSN 0006-3002

Nitric oxide synthase

Calabrese, Vittorio and Scapagnini, Giovanni and Ravagna, Agrippino and Bella, Rita and Foresti, Roberta and Bates, Timothy E. and Giuffrida Stella, Anna-Maria and Pennisi, Giovanni (2002) Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels. Journal of Neuroscience Research, 70 (4). pp. 580-7. ISSN 0360-4012

Oxidative Phosphorylation

Bates, T. E and Loesch, A. and Burnstock, G. and Clark, J. B. (1995) Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver. Biochemical and biophysical research communications, 213 (3). pp. 896-900. ISSN 0006-291X

Oxidative Stress

Heales, S. J. and Davies, S. E. and Bates, T. E. and Clark, J. B. (1995) Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration. Neurochemical research, 20 (1). pp. 31-38. ISSN 0364-3190

Oxidative phsphorylation

Bates, Timothy E. and Strangward, Maria and Keelan, Julia and Davey, Gavin P. and Munro, Peter M. G. and Clark, John B. (1996) Inhibition of N-acetylaspartate production: implications for 1H MRS studies in vivo. Neuroreport, 7 (8). pp. 1397-1400. ISSN 0959-4965

Oxidative stress

Calabrese, V. and Scapagnini, G. and Catalano, C. and Bates, T. E. and Dinotta, F. and Micali, G. and Giuffrida Stella, A. M. (2001) Induction of heat shock protein synthesis in human skin fibroblasts in response to oxidative stress: regulation by a natural antioxidant from rosemary extract. International Journal of Tissue Reactions, 23 (2). pp. 51-8. ISSN 0250-0868

PBN

Kuroda, Satoshi and Katsura, Ken-ichiro and Hillered, Lars and Bates, Timothy E. and Siesjö, Bo K. (1996) Delayed treatment with alpha-phenyl-N-tert-butyl nitrone (PBN) attenuates secondary mitochondrial dysfunction after transient focal cerebral ischemia in the rat. Neurobiology of Disease, 3 (2). pp. 149-157. ISSN 0969-9961

Parkinson's disease

Rosin, Claudia and Colombo, Sergio and Calver, Andrew A. and Bates, Timothy E. and Skaper, Stephen D. (2005) Dopamine D2 and D3 receptor agonists limit oligodendrocyte injury caused by glutamate oxidative stress and oxygen/glucose deprivation. Glia, 52 (4). pp. 336-343. ISSN 0894-1491

Phosphodiester

Murphy, Elizabeth J. and Bates, Timothy E. and Williams, Stephen R. and Watson, Tracey and Brindle, Kevin M. and Rajagopalan, Bheeshma and Radda, George K. (1992) Endoplasmic reticulum: the major contributor to the PDE peak in hepatic 31P-NMR spectra at low magnetic field strengths. Biochimica et biophysica acta: biomembranes, 1111 (1). pp. 51-58. ISSN 0005-2736

Prostate cancer

Dagnelie, Pieter C. and Bell, Jimmy D. and Williams, Steve C. and Bates, Timothy E. and Abel, Paul D. and Foster, Christopher S. (1994) Effect of fish oil on cancer cachexia and host liver metabolism in rats with prostate tumors. Lipids, 29 (3). pp. 195-203. ISSN 0024-4201

Reperfusion

Almeida, Angeles and Allen, Kathryn L. and Bates, TImothy E. and Clark, John B. (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. Journal of neurochemistry, 65 (4). pp. 1698-1703. ISSN 0022-3042

Reperfusion injury

Almeida, Angeles and Allen, Kathryn L. and Bates, TImothy E. and Clark, John B. (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. Journal of neurochemistry, 65 (4). pp. 1698-1703. ISSN 0022-3042

Sammut, Ivan A. and Jayakumar, Jay and Latif, Najmi and Rothery, Stephen and Severs, Nicholas J. and Smolenski, Ryszard T. and Bates, Timothy E. and Yacoub, Magdi H. (2001) Heat stress contributes to the enhancement of cardiac mitochondrial complex activity. The American Journal of Pathology, 158 (5). pp. 1821-31. ISSN 0002-9440

Reproducibility

Klonizakis, Markos and Manning, Gillian and Donnelly, Richard (2011) Assessment of lower limb microcirculation: exploring the reproducibility and clinical application of laser doppler techniques. Skin Pharmacology and Physiology: Journal of Pharmacological and Biophysical Research, 24 (3). pp. 136-143. ISSN 1660-5527

Tew, G. and Klonizakis, Markos and Moss, J. and Ruddock, A. D. and Saxton, J. M. and Hodges, G. J. (2011) Reproducibility of cutaneous thermal hyperaemia assessed by laser Doppler flowmetry in young and older adults. Microvascular Research, 81 (2). pp. 177-182. ISSN 0026-2862

Respiratory chain

Almeida, Angeles and Allen, Kathryn L. and Bates, TImothy E. and Clark, John B. (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. Journal of neurochemistry, 65 (4). pp. 1698-1703. ISSN 0022-3042

S-nitrosothiols

Calabrese, Vittorio and Scapagnini, Giovanni and Ravagna, Agrippino and Bella, Rita and Foresti, Roberta and Bates, Timothy E. and Giuffrida Stella, Anna-Maria and Pennisi, Giovanni (2002) Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels. Journal of Neuroscience Research, 70 (4). pp. 580-7. ISSN 0360-4012

SB366791

Athanasiou, Andriani and Smith, Paul A. and Vakilpour, Sara and Kumaran, Nethia M. and Turner, Amy E. and Bagiokou, Dimitra and Layfield, Robert and Ray, David E. and Westwell, Andrew D. and Alexander, Stephen P. H. and Kendall, David A. and Lobo, Dileep N. and Watson, Susan A. and Lophatanon, Artitaya and Muir, Kenneth A. and Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

Skeletal Muscle

Bates, T. E. and Loesch, A. and Burnstock, G. and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochemical and biophysical research communications, 218 (1). pp. 40-44. ISSN 0006-291X

Skin blood flow

Klonizakis, Markos (2012) Studying the cutaneous microcirculatory response during upper-limb exercise in healthy, older, sedentary people. Clinical Hemorheology and Microcirculation, 51 (1). pp. 69-75. ISSN 1386-0281

Tew, G. and Klonizakis, Markos and Moss, J. and Ruddock, A. D. and Saxton, J. M. and Hodges, G. J. (2011) Reproducibility of cutaneous thermal hyperaemia assessed by laser Doppler flowmetry in young and older adults. Microvascular Research, 81 (2). pp. 177-182. ISSN 0026-2862

Tew, G. and Klonizakis, Markos and Moss, J. and Ruddock, A. and Saxton, J. M. and Hodges, G. (2010) Role of sensory nerves in the rapid cutaneous vasodilator response to local heating in young and older endurance-trained and untrained men. In: 9th World Congress on Microcirculation, 26 - 28 September 2010, Maison de la Chimie, Paris.

Tew, G. A. and Saxton, J. M. and Klonizakis, Markos and Moss, J. and Ruddock, A. D. and Hodges, G. J. (2011) Aging and aerobic fitness affect the contribution of noradrenergic sympathetic nerves to the rapid cutaneous vasodilator response to local heating. Journal of Applied Physiology, 110 (5). pp. 1264-1270. ISSN 8750-7587

Synaptic

Almeida, A. and Brooks, K. J. and Sammut, I. and Keelan, J. and Davey, G. P. and Clark, J. B. and Bates, T. E. (1995) Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain. Developmental neuroscience, 17 (4). pp. 212-218. ISSN 0378-5866

Synaptosomal

Almeida, A. and Brooks, K. J. and Sammut, I. and Keelan, J. and Davey, G. P. and Clark, J. B. and Bates, T. E. (1995) Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain. Developmental Neuroscience, 17 (4). pp. 212-218. ISSN 0378-5866

Bates, T. E and Loesch, A. and Burnstock, G. and Clark, J. B. (1995) Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver. Biochemical and biophysical research communications, 213 (3). pp. 896-900. ISSN 0006-291X

Synaptosomes

Allen, Kathryn L. and Almeida, Angeles and Bates, Timothy E. and Clark, John B. (1995) Changes of respiratory chain activity in mitochondrial and synaptosomal fractions isolated from the gerbil brain after graded ischaemia. Journal of neurochemistry, 64 (5). pp. 2222-2229. ISSN 0022-3042

Almeida, A. and Brooks, K. J. and Sammut, I. and Keelan, J. and Davey, G. P. and Clark, J. B. and Bates, T. E. (1995) Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain. Developmental neuroscience, 17 (4). pp. 212-218. ISSN 0378-5866

Keelan, J. and Brand, M. P. and Bates, T. E. and Land, J. M. and Clark, J. B. and Heales, S. J. (1996) Nitric oxide and antioxidant status in glucose and oxygen deprived neonatal and adult rat brain synaptosomes. Neurochemical Research, 21 (8). pp. 923-7. ISSN 0364-3190

Keelan, Julie and Bates, Timothy E. and Clark, John B. (1999) Heightened resistance of the neonatal brain to ischemia-reperfusion involves a lack of mitochondrial damage in the nerve terminal. Brain research, 821 (1). pp. 124-33. ISSN 0006-8993

Keelan, Julie and Bates, Timothy E. and Clark, John B. (1996) Intrasynaptosomal free calcium concentration during rat brain development: effects of hypoxia, aglycaemia, and ischaemia. Journal of neurochemistry, 66 (6). pp. 2460-7. ISSN 0022-3042

TASTPM

Pardon, Marie-Christine and Sarmad, Sarir and Rattray, Ivan and Bates, Timothy E. and Scullion, Gillian A. and Marsden, Charles A. and Barrett, David A. and Lowe, James and Kendall, David A. (2009) Repeated novel cage exposure-induced improvement of early Alzheimer's-like cognitive and amyloid changes in TASTPM mice is unrelated to changes in brain endocannabinoids levels. Neurobiology of Aging, 30 (7). pp. 1099-1113. ISSN 0197-4580

THC

Athanasiou, Andriani and Clarke, Anna B. and Turner, Amy E. and Kumaran, Nethia M. and Vakilpour, Sara and Smith, Paul A. and Bagiokou, Dimitra and Bradshaw, Tracey D. and Westwell, Andrew D. and Fang, Lin and Lobo, Dileep N. and Constantinescu, Cris S. and Calabrese, Vittorio and Loesch, Andrzej and Alexander, Stephen P. H. and Clothier, Richard H. and Kendall, David A. and Bates, Timothy E. (2007) Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications, 364 (1). pp. 131-137. ISSN 0006-291x

TRPV1

Athanasiou, Andriani and Smith, Paul A. and Vakilpour, Sara and Kumaran, Nethia M. and Turner, Amy E. and Bagiokou, Dimitra and Layfield, Robert and Ray, David E. and Westwell, Andrew D. and Alexander, Stephen P. H. and Kendall, David A. and Lobo, Dileep N. and Watson, Susan A. and Lophatanon, Artitaya and Muir, Kenneth A. and Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

Transplantation

Sammut, Ivan A. and Thorniley, Maureen S. and Simpkin, Sandra and Fuller, Barry J. and Bates, Timothy E. and Green, Colin J. (1998) Impairment of hepatic mitochondrial respiratory function following storage and orthotopic transplantation of rat livers. Cryobiology, 36 (1). pp. 49-60. ISSN 0011-2240

Vanilloid

Athanasiou, Andriani and Smith, Paul A. and Vakilpour, Sara and Kumaran, Nethia M. and Turner, Amy E. and Bagiokou, Dimitra and Layfield, Robert and Ray, David E. and Westwell, Andrew D. and Alexander, Stephen P. H. and Kendall, David A. and Lobo, Dileep N. and Watson, Susan A. and Lophatanon, Artitaya and Muir, Kenneth A. and Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

Vanilloids

Athanasiou, Andriani and Smith, Paul A. and Vakilpour, Sara and Kumaran, Nethia M. and Turner, Amy E. and Bagiokou, Dimitra and Layfield, Robert and Ray, David E. and Westwell, Andrew D. and Alexander, Stephen P. H. and Kendall, David A. and Lobo, Dileep N. and Watson, Susan A. and Lophatanon, Artitaya and Muir, Kenneth A. and Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

acetyl carnitine

Calabrese, V. and Scapagnini, G. and Catalano, C. and Dinotta, F. and Bates, T. E. and Calvani, M. and Stella, A. M. (2001) Effects of acetyl-L-carnitine on the formation of fatty acid ethyl esters in brain and peripheral organs after short-term ethanol administration in rat. Neurochemical Research, 26 (2). pp. 167-74. ISSN 0364-3190

acetyl-L-carnitine

Mancuso, Cesare and Bates, Timothy E. and Butterfield, D. Allan and Calafato, Stella and Cornelius, Carolin and De Lorenzo, Antonino and Dinkova Kostova, Albena T. and Calabrese, Vittorio (2007) Natural antioxidants in Alzheimer's disease. Expert Opinion on Investigational Drugs, 16 (12). pp. 1921-1931. ISSN 1354-3784

age

Tew, G. A. and Saxton, J. M. and Klonizakis, Markos and Moss, J. and Ruddock, A. D. and Hodges, G. J. (2011) Aging and aerobic fitness affect the contribution of noradrenergic sympathetic nerves to the rapid cutaneous vasodilator response to local heating. Journal of Applied Physiology, 110 (5). pp. 1264-1270. ISSN 8750-7587

aging

Calabrese, V. and Scapagnini, G. and Giuffrida Stella, A. M. and Bates, T. E. and Clark, J. B. (2001) Mitochondrial involvement in brain function and dysfunction: relevance to aging, neurodegenerative disorders and longevity. Neurochemical Research, 26 (6). pp. 739-64. ISSN 0364-3190

aglycemia

Brooks, K. J. and Clark, J. B. and Bates, T. E. (1996) Assessment of energy metabolism in the developing brain following aglycemic hypoxia by 1H and 31P NMR. Neurochemical Research, 21 (9). pp. 1089-1095. ISSN 0364-3190

Brooks, K. J. and Hargreaves, I. P. and Bates, T. E. (2000) Nitric-oxide-induced inhibition of mitochondrial complexes following aglycaemic hypoxia in neonatal cortical rat brain slices. Developmental Neuroscience, 22 (5-6). pp. 359-65. ISSN 0378-5866

Brooks, Keith J. and Clark, John B. and Bates, Timothy E. (1998) 3-Hydroxybutyrate aids the recovery of the energy state from aglycaemic hypoxia of adult but not neonatal rat brain slices. Journal of Neurochemistry, 70 (5). pp. 1986-1990. ISSN 0022-3042

Keelan, J. and Brand, M. P. and Bates, T. E. and Land, J. M. and Clark, J. B. and Heales, S. J. (1996) Nitric oxide and antioxidant status in glucose and oxygen deprived neonatal and adult rat brain synaptosomes. Neurochemical Research, 21 (8). pp. 923-7. ISSN 0364-3190

Keelan, Julie and Bates, Timothy E. and Clark, John B. (1996) Intrasynaptosomal free calcium concentration during rat brain development: effects of hypoxia, aglycaemia, and ischaemia. Journal of neurochemistry, 66 (6). pp. 2460-7. ISSN 0022-3042

amyloid

Canevari, Laura and Clark, John B. and Bates, Timothy E. (1999) Beta-amyloid fragment 25-35 selectively decreases complex IV activity in isolated mitochondria. FEBS Letters, 457 (1). pp. 131-4. ISSN 0014-5793

amyloid precursor protein

Canevari, Laura and Clark, John B. and Bates, Timothy E. (1999) Beta-amyloid fragment 25-35 selectively decreases complex IV activity in isolated mitochondria. FEBS Letters, 457 (1). pp. 131-4. ISSN 0014-5793

Pardon, Marie-Christine and Sarmad, Sarir and Rattray, Ivan and Bates, Timothy E. and Scullion, Gillian A. and Marsden, Charles A. and Barrett, David A. and Lowe, James and Kendall, David A. (2009) Repeated novel cage exposure-induced improvement of early Alzheimer's-like cognitive and amyloid changes in TASTPM mice is unrelated to changes in brain endocannabinoids levels. Neurobiology of Aging, 30 (7). pp. 1099-1113. ISSN 0197-4580

anandamide

Athanasiou, Andriani and Clarke, Anna B. and Turner, Amy E. and Kumaran, Nethia M. and Vakilpour, Sara and Smith, Paul A. and Bagiokou, Dimitra and Bradshaw, Tracey D. and Westwell, Andrew D. and Fang, Lin and Lobo, Dileep N. and Constantinescu, Cris S. and Calabrese, Vittorio and Loesch, Andrzej and Alexander, Stephen P. H. and Clothier, Richard H. and Kendall, David A. and Bates, Timothy E. (2007) Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications, 364 (1). pp. 131-137. ISSN 0006-291x

anticancer

Daley, E. and Wilkie, D. and Loesch, A. and Hargreaves, I. P. and Kendall, D. A. and Pilkington, G. J. and Bates, T. E. (2005) Chlorimipramine: a novel anticancer agent with a mitochondrial target. Biochemical and Biophysical Research Communications, 328 (2). pp. 623-632. ISSN 0006-291X

antidepressants

Daley, E. and Wilkie, D. and Loesch, A. and Hargreaves, I. P. and Kendall, D. A. and Pilkington, G. J. and Bates, T. E. (2005) Chlorimipramine: a novel anticancer agent with a mitochondrial target. Biochemical and Biophysical Research Communications, 328 (2). pp. 623-632. ISSN 0006-291X

antisense cDNA

Levicar, Natasa and Dewey, Ricardo A. and Daley, Emma and Bates, Timothy E. and Davies, Derek and Kos, Janko and Pilkington, Geoffrey J. and Lah, Tamara T. (2003) Selective suppression of cathepsin L by antisense cDNA impairs human brain tumor cell invasion in vitro and promotes apoptosis. Cancer Gene Therapy, 10 (2). pp. 141-51. ISSN 0929-1903

apoptosis

Athanasiou, Andriani and Clarke, Anna B. and Turner, Amy E. and Kumaran, Nethia M. and Vakilpour, Sara and Smith, Paul A. and Bagiokou, Dimitra and Bradshaw, Tracey D. and Westwell, Andrew D. and Fang, Lin and Lobo, Dileep N. and Constantinescu, Cris S. and Calabrese, Vittorio and Loesch, Andrzej and Alexander, Stephen P. H. and Clothier, Richard H. and Kendall, David A. and Bates, Timothy E. (2007) Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications, 364 (1). pp. 131-137. ISSN 0006-291x

Athanasiou, Andriani and Smith, Paul A. and Vakilpour, Sara and Kumaran, Nethia M. and Turner, Amy E. and Bagiokou, Dimitra and Layfield, Robert and Ray, David E. and Westwell, Andrew D. and Alexander, Stephen P. H. and Kendall, David A. and Lobo, Dileep N. and Watson, Susan A. and Lophatanon, Artitaya and Muir, Kenneth A. and Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

Daley, E. and Wilkie, D. and Loesch, A. and Hargreaves, I. P. and Kendall, D. A. and Pilkington, G. J. and Bates, T. E. (2005) Chlorimipramine: a novel anticancer agent with a mitochondrial target. Biochemical and Biophysical Research Communications, 328 (2). pp. 623-632. ISSN 0006-291X

Levicar, Natasa and Dewey, Ricardo A. and Daley, Emma and Bates, Timothy E. and Davies, Derek and Kos, Janko and Pilkington, Geoffrey J. and Lah, Tamara T. (2003) Selective suppression of cathepsin L by antisense cDNA impairs human brain tumor cell invasion in vitro and promotes apoptosis. Cancer Gene Therapy, 10 (2). pp. 141-51. ISSN 0929-1903

arm-cranking exercise

Klonizakis, Markos (2012) Studying the cutaneous microcirculatory response during upper-limb exercise in healthy, older, sedentary people. Clinical Hemorheology and Microcirculation, 51 (1). pp. 69-75. ISSN 1386-0281

blood flow

Tew, Garry A. and Klonizakis, Markos and Crank, Helen and Briers, J. David and Hodges, Gary J. (2011) Comparison of laser speckle contrast imaging with laser Doppler for assessing microvascular function. Microvascular Research, 82 (3). pp. 326-332. ISSN 0026-2862

bmjanomaly

Almeida, A. and Brooks, K. J. and Sammut, I. and Keelan, J. and Davey, G. P. and Clark, J. B. and Bates, T. E. (1995) Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain. Developmental neuroscience, 17 (4). pp. 212-218. ISSN 0378-5866

bmjdoi

Brooks, K. J. and Hargreaves, I. P. and Clark, J. B. and Bates, Timothy (1998) Ischaemia-induced damage to mitochondrial complexes in the neonatal brain--role of NO. Biochemical Society Transactions, 26 (4). S343. ISSN 0300-5127

brain

Almeida, A. and Brooks, K. J. and Sammut, I. and Keelan, J. and Davey, G. P. and Clark, J. B. and Bates, T. E. (1995) Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain. Developmental Neuroscience, 17 (4). pp. 212-218. ISSN 0378-5866

Almeida, Angeles and Allen, Kathryn L. and Bates, TImothy E. and Clark, John B. (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. Journal of neurochemistry, 65 (4). pp. 1698-1703. ISSN 0022-3042

Bates, T E and Almeida, A and Heales, S J and Clark, J B (1994) Postnatal development of the complexes of the electron transport chain in isolated rat brain mitochondria. Developmental neuroscience, 16 (5-6). pp. 321-7. ISSN 0378-5866

Brooks, K. J. and Hargreaves, I. P. and Clark, J. B. and Bates, Timothy (1998) Ischaemia-induced damage to mitochondrial complexes in the neonatal brain--role of NO. Biochemical Society Transactions, 26 (4). S343. ISSN 0300-5127

Brooks, Keith J and Hargreaves, Iain and Bhakoo, Kishore and Sellwood, Mark and O'Brien, Francis and Noone, Martina and Sakata, Yasuko and Cady, Ernest and Wylezinska, Marzena and Thornton, John and Ordidge, Roger and Nguyen, Quyen and Clemence, Matthew and Wyatt, John and Bates, Timothy E. (2002) Delayed hypothermia prevents decreases in N-acetylaspartate and reduced glutathione in the cerebral cortex of the neonatal pig following transient hypoxia-ischaemia. Neurochemical Research, 27 (12). pp. 1599-604. ISSN 0364-3190

Brooks, Keith J. and Clark, John B. and Bates, Timothy E. (1998) 3-Hydroxybutyrate aids the recovery of the energy state from aglycaemic hypoxia of adult but not neonatal rat brain slices. Journal of Neurochemistry, 70 (5). pp. 1986-1990. ISSN 0022-3042

Calabrese, V. and Bates, T. E. and Stella, A. M. (2000) NO synthase and NO-dependent signal pathways in brain aging and neurodegenerative disorders: the role of oxidant/antioxidant balance. Neurochemical Research, 25 (9-10). pp. 1315-41. ISSN 0364-3190

Calabrese, V. and Scapagnini, G. and Catalano, C. and Dinotta, F. and Bates, T. E. and Calvani, M. and Stella, A. M. (2001) Effects of acetyl-L-carnitine on the formation of fatty acid ethyl esters in brain and peripheral organs after short-term ethanol administration in rat. Neurochemical Research, 26 (2). pp. 167-74. ISSN 0364-3190

Calabrese, V. and Scapagnini, G. and Giuffrida Stella, A. M. and Bates, T. E. and Clark, J. B. (2001) Mitochondrial involvement in brain function and dysfunction: relevance to aging, neurodegenerative disorders and longevity. Neurochemical Research, 26 (6). pp. 739-64. ISSN 0364-3190

Canevari, Laura and Clark, John B. and Bates, Timothy E. (1999) Beta-amyloid fragment 25-35 selectively decreases complex IV activity in isolated mitochondria. FEBS Letters, 457 (1). pp. 131-4. ISSN 0014-5793

Keelan, Julie and Bates, Timothy E. and Clark, John B. (1999) Heightened resistance of the neonatal brain to ischemia-reperfusion involves a lack of mitochondrial damage in the nerve terminal. Brain research, 821 (1). pp. 124-33. ISSN 0006-8993

Kristián, Tibor and Gertsch, Jeff and Bates, Timothy E. and Siesjö, Bo K. (2000) Characteristics of the calcium-triggered mitochondrial permeability transition in nonsynaptic brain mitochondria: effect of cyclosporin A and ubiquinone O. Journal of Neurochemistry, 74 (5). pp. 1999-2009. ISSN 0022-3042

Kristián, Tibor and Weatherby, Tina M. and Bates, Timothy E. and Fiskum, Gary (2002) Heterogeneity of the calcium-induced permeability transition in isolated non-synaptic brain mitochondria. Journal of Neurochemistry, 83 (6). pp. 1297-308. ISSN 0022-3042

brain slices

Brooks, K. J. and Clark, J. B. and Bates, T. E. (1996) Assessment of energy metabolism in the developing brain following aglycemic hypoxia by 1H and 31P NMR. Neurochemical Research, 21 (9). pp. 1089-1095. ISSN 0364-3190

Brooks, K. J. and Hargreaves, I. P. and Bates, T. E. (2000) Nitric-oxide-induced inhibition of mitochondrial complexes following aglycaemic hypoxia in neonatal cortical rat brain slices. Developmental Neuroscience, 22 (5-6). pp. 359-65. ISSN 0378-5866

Brooks, Keith J. and Clark, John B. and Bates, Timothy E. (1998) 3-Hydroxybutyrate aids the recovery of the energy state from aglycaemic hypoxia of adult but not neonatal rat brain slices. Journal of Neurochemistry, 70 (5). pp. 1986-1990. ISSN 0022-3042

calcium

Kristián, Tibor and Gertsch, Jeff and Bates, Timothy E. and Siesjö, Bo K. (2000) Characteristics of the calcium-triggered mitochondrial permeability transition in nonsynaptic brain mitochondria: effect of cyclosporin A and ubiquinone O. Journal of Neurochemistry, 74 (5). pp. 1999-2009. ISSN 0022-3042

Kristián, Tibor and Weatherby, Tina M. and Bates, Timothy E. and Fiskum, Gary (2002) Heterogeneity of the calcium-induced permeability transition in isolated non-synaptic brain mitochondria. Journal of Neurochemistry, 83 (6). pp. 1297-308. ISSN 0022-3042

cancer

Athanasiou, Andriani and Smith, Paul A. and Vakilpour, Sara and Kumaran, Nethia M. and Turner, Amy E. and Bagiokou, Dimitra and Layfield, Robert and Ray, David E. and Westwell, Andrew D. and Alexander, Stephen P. H. and Kendall, David A. and Lobo, Dileep N. and Watson, Susan A. and Lophatanon, Artitaya and Muir, Kenneth A. and Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

Dagnelie, P. C. and Bell, J. D. and Williams, S. C. and Bates, T. E. and Abel, P. D. and Foster, C. S. (1993) Altered phosphorylation status, phospholipid metabolism and gluconeogenesis in the host liver of rats with prostate cancer: a 31P magnetic resonance spectroscopy study. British Journal of Cancer, 67 (6). pp. 1303-1309. ISSN 0007-0920

Daley, E. and Wilkie, D. and Loesch, A. and Hargreaves, I. P. and Kendall, D. A. and Pilkington, G. J. and Bates, T. E. (2005) Chlorimipramine: a novel anticancer agent with a mitochondrial target. Biochemical and Biophysical Research Communications, 328 (2). pp. 623-632. ISSN 0006-291X

cannabinoid

Athanasiou, Andriani and Clarke, Anna B. and Turner, Amy E. and Kumaran, Nethia M. and Vakilpour, Sara and Smith, Paul A. and Bagiokou, Dimitra and Bradshaw, Tracey D. and Westwell, Andrew D. and Fang, Lin and Lobo, Dileep N. and Constantinescu, Cris S. and Calabrese, Vittorio and Loesch, Andrzej and Alexander, Stephen P. H. and Clothier, Richard H. and Kendall, David A. and Bates, Timothy E. (2007) Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications, 364 (1). pp. 131-137. ISSN 0006-291x

capsazepine

Athanasiou, Andriani and Smith, Paul A. and Vakilpour, Sara and Kumaran, Nethia M. and Turner, Amy E. and Bagiokou, Dimitra and Layfield, Robert and Ray, David E. and Westwell, Andrew D. and Alexander, Stephen P. H. and Kendall, David A. and Lobo, Dileep N. and Watson, Susan A. and Lophatanon, Artitaya and Muir, Kenneth A. and Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

cardiac

Sammut, Ivan A. and Jayakumar, Jay and Latif, Najmi and Rothery, Stephen and Severs, Nicholas J. and Smolenski, Ryszard T. and Bates, Timothy E. and Yacoub, Magdi H. (2001) Heat stress contributes to the enhancement of cardiac mitochondrial complex activity. The American Journal of Pathology, 158 (5). pp. 1821-31. ISSN 0002-9440

cell invasion

Levicar, Natasa and Dewey, Ricardo A. and Daley, Emma and Bates, Timothy E. and Davies, Derek and Kos, Janko and Pilkington, Geoffrey J. and Lah, Tamara T. (2003) Selective suppression of cathepsin L by antisense cDNA impairs human brain tumor cell invasion in vitro and promotes apoptosis. Cancer Gene Therapy, 10 (2). pp. 141-51. ISSN 0929-1903

cellular stress

Calabrese, Vittorio and Bates, Timothy E. and Mancuso, Cesare and Cornelius, Carolin and Ventimiglia, Bernardo and Cambria, Maria Teresa and Di Renzo, Laura and De Lorenzo, Antonino and Dinkova-Kostova, Albena T. (2008) Curcumin and the cellular stress response in free radical-related diseases. Molecular Nutrition & Food Research, 52 (9). pp. 1062-1073. ISSN 1613-4125

cerebral ischaemia

Almeida, Angeles and Allen, Kathryn L. and Bates, TImothy E. and Clark, John B. (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. Journal of neurochemistry, 65 (4). pp. 1698-1703. ISSN 0022-3042

cerebral ischemia

Almeida, Angeles and Allen, Kathryn L. and Bates, TImothy E. and Clark, John B. (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. Journal of neurochemistry, 65 (4). pp. 1698-1703. ISSN 0022-3042

Brooks, Keith J and Hargreaves, Iain and Bhakoo, Kishore and Sellwood, Mark and O'Brien, Francis and Noone, Martina and Sakata, Yasuko and Cady, Ernest and Wylezinska, Marzena and Thornton, John and Ordidge, Roger and Nguyen, Quyen and Clemence, Matthew and Wyatt, John and Bates, Timothy E. (2002) Delayed hypothermia prevents decreases in N-acetylaspartate and reduced glutathione in the cerebral cortex of the neonatal pig following transient hypoxia-ischaemia. Neurochemical Research, 27 (12). pp. 1599-604. ISSN 0364-3190

Canevari, Laura and Console, Antonella and Tendi, E. A. and Clark, J. B. and Bates, Timothy (1999) Effect of postischaemic hypothermia on the mitochondrial damage induced by ischaemia and reperfusion in the gerbil. Brain research, 817 (1-2). pp. 241-245. ISSN 0006-8993

cerebroprotection

Canevari, Laura and Console, Antonella and Tendi, E. A. and Clark, J. B. and Bates, Timothy (1999) Effect of postischaemic hypothermia on the mitochondrial damage induced by ischaemia and reperfusion in the gerbil. Brain research, 817 (1-2). pp. 241-245. ISSN 0006-8993

chlorimipramine

Daley, E. and Wilkie, D. and Loesch, A. and Hargreaves, I. P. and Kendall, D. A. and Pilkington, G. J. and Bates, T. E. (2005) Chlorimipramine: a novel anticancer agent with a mitochondrial target. Biochemical and Biophysical Research Communications, 328 (2). pp. 623-632. ISSN 0006-291X

clomipramine

Daley, E. and Wilkie, D. and Loesch, A. and Hargreaves, I. P. and Kendall, D. A. and Pilkington, G. J. and Bates, T. E. (2005) Chlorimipramine: a novel anticancer agent with a mitochondrial target. Biochemical and Biophysical Research Communications, 328 (2). pp. 623-632. ISSN 0006-291X

complexexs

Almeida, Angeles and Allen, Kathryn L. and Bates, TImothy E. and Clark, John B. (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. Journal of neurochemistry, 65 (4). pp. 1698-1703. ISSN 0022-3042

curcumin

Calabrese, Vittorio and Bates, Timothy E. and Mancuso, Cesare and Cornelius, Carolin and Ventimiglia, Bernardo and Cambria, Maria Teresa and Di Renzo, Laura and De Lorenzo, Antonino and Dinkova-Kostova, Albena T. (2008) Curcumin and the cellular stress response in free radical-related diseases. Molecular Nutrition & Food Research, 52 (9). pp. 1062-1073. ISSN 1613-4125

Mancuso, Cesare and Bates, Timothy E. and Butterfield, D. Allan and Calafato, Stella and Cornelius, Carolin and De Lorenzo, Antonino and Dinkova Kostova, Albena T. and Calabrese, Vittorio (2007) Natural antioxidants in Alzheimer's disease. Expert Opinion on Investigational Drugs, 16 (12). pp. 1921-1931. ISSN 1354-3784

cutaneous microcirculation

Klonizakis, Markos (2012) Studying the cutaneous microcirculatory response during upper-limb exercise in healthy, older, sedentary people. Clinical Hemorheology and Microcirculation, 51 (1). pp. 69-75. ISSN 1386-0281

cytochrome oxidase

Cooper, Chris E. and Davies, Nathan A. and Psychoulis, Minas and Canevari, Laura and Bates, Tim E. and Dobbie, Michael S. and Casley, Christopher S. and Sharpe, Martyn A. (2003) Nitric oxide and peroxynitrite cause irreversible increases in the K(m) for oxygen of mitochondrial cytochrome oxidase: in vitro and in vivo studies. Biochimica et Biophysica Acta: general subjects, 1607 (1). pp. 27-34. ISSN 0006-3002

development

Almeida, A. and Brooks, K. J. and Sammut, I. and Keelan, J. and Davey, G. P. and Clark, J. B. and Bates, T. E. (1995) Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain. Developmental Neuroscience, 17 (4). pp. 212-218. ISSN 0378-5866

Bates, T E and Almeida, A and Heales, S J and Clark, J B (1994) Postnatal development of the complexes of the electron transport chain in isolated rat brain mitochondria. Developmental neuroscience, 16 (5-6). pp. 321-7. ISSN 0378-5866

dopamine

Rosin, Claudia and Colombo, Sergio and Calver, Andrew A. and Bates, Timothy E. and Skaper, Stephen D. (2005) Dopamine D2 and D3 receptor agonists limit oligodendrocyte injury caused by glutamate oxidative stress and oxygen/glucose deprivation. Glia, 52 (4). pp. 336-343. ISSN 0894-1491

dopamine receptor

Rosin, Claudia and Colombo, Sergio and Calver, Andrew A. and Bates, Timothy E. and Skaper, Stephen D. (2005) Dopamine D2 and D3 receptor agonists limit oligodendrocyte injury caused by glutamate oxidative stress and oxygen/glucose deprivation. Glia, 52 (4). pp. 336-343. ISSN 0894-1491

dysfunction

Calabrese, V. and Scapagnini, G. and Giuffrida Stella, A. M. and Bates, T. E. and Clark, J. B. (2001) Mitochondrial involvement in brain function and dysfunction: relevance to aging, neurodegenerative disorders and longevity. Neurochemical Research, 26 (6). pp. 739-64. ISSN 0364-3190

eNOS

Bates, T. E. and Loesch, A. and Burnstock, G. and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochemical and biophysical research communications, 218 (1). pp. 40-44. ISSN 0006-291X

electron transport chain

Bates, T E and Almeida, A and Heales, S J and Clark, J B (1994) Postnatal development of the complexes of the electron transport chain in isolated rat brain mitochondria. Developmental neuroscience, 16 (5-6). pp. 321-7. ISSN 0378-5866

endocannabinoid

Pardon, Marie-Christine and Sarmad, Sarir and Rattray, Ivan and Bates, Timothy E. and Scullion, Gillian A. and Marsden, Charles A. and Barrett, David A. and Lowe, James and Kendall, David A. (2009) Repeated novel cage exposure-induced improvement of early Alzheimer's-like cognitive and amyloid changes in TASTPM mice is unrelated to changes in brain endocannabinoids levels. Neurobiology of Aging, 30 (7). pp. 1099-1113. ISSN 0197-4580

enzymes

Bates, T E and Almeida, A and Heales, S J and Clark, J B (1994) Postnatal development of the complexes of the electron transport chain in isolated rat brain mitochondria. Developmental neuroscience, 16 (5-6). pp. 321-7. ISSN 0378-5866

Bates, Timothy E. and Strangward, Maria and Keelan, Julia and Davey, Gavin P. and Munro, Peter M. G. and Clark, John B. (1996) Inhibition of N-acetylaspartate production: implications for 1H MRS studies in vivo. Neuroreport, 7 (8). pp. 1397-1400. ISSN 0959-4965

ethanol

Calabrese, V. and Scapagnini, G. and Catalano, C. and Dinotta, F. and Bates, T. E. and Calvani, M. and Stella, A. M. (2001) Effects of acetyl-L-carnitine on the formation of fatty acid ethyl esters in brain and peripheral organs after short-term ethanol administration in rat. Neurochemical Research, 26 (2). pp. 167-74. ISSN 0364-3190

Calabrese, Vittorio and Testa, Guiseppe and Ravagna, Agrippino and Bates, Timothy Edward and Stella, Anna Maria (2000) HSP70 induction in the brain following ethanol administration in the rat: regulation by glutathione redox state. Biochemical and Biophysical Research Communications, 269 (2). pp. 397-400. ISSN 0006-291X

excitotoxicity

Rosin, Claudia and Bates, Timothy E. and Skaper, Stephen D. (2004) Excitatory amino acid induced oligodendrocyte cell death in vitro: receptor-dependent and -independent mechanisms. Journal of Neurochemistry, 90 (5). pp. 1173-1185. ISSN 0022-3042

fatty acids

Dagnelie, Pieter C. and Bell, Jimmy D. and Williams, Steve C. and Bates, Timothy E. and Abel, Paul D. and Foster, Christopher S. (1994) Effect of fish oil on cancer cachexia and host liver metabolism in rats with prostate tumors. Lipids, 29 (3). pp. 195-203. ISSN 0024-4201

fibroblast

Calabrese, V. and Scapagnini, G. and Catalano, C. and Bates, T. E. and Dinotta, F. and Micali, G. and Giuffrida Stella, A. M. (2001) Induction of heat shock protein synthesis in human skin fibroblasts in response to oxidative stress: regulation by a natural antioxidant from rosemary extract. International Journal of Tissue Reactions, 23 (2). pp. 51-8. ISSN 0250-0868

Calabrese, V. and Scapagnini, G. and Catalano, C. and Bates, T. E. and Geraci, D. and Pennisi, G. and Giuffrida Stella, A. M. (2001) Regulation of heat shock protein synthesis in human skin fibroblasts in response to oxidative stress: role of vitamin E. International Journal of Tissue Reactions, 23 (4). pp. 127-35. ISSN 0250-0868

free radicals

Calabrese, Vittorio and Bates, Timothy E. and Mancuso, Cesare and Cornelius, Carolin and Ventimiglia, Bernardo and Cambria, Maria Teresa and Di Renzo, Laura and De Lorenzo, Antonino and Dinkova-Kostova, Albena T. (2008) Curcumin and the cellular stress response in free radical-related diseases. Molecular Nutrition & Food Research, 52 (9). pp. 1062-1073. ISSN 1613-4125

function

Calabrese, V. and Scapagnini, G. and Giuffrida Stella, A. M. and Bates, T. E. and Clark, J. B. (2001) Mitochondrial involvement in brain function and dysfunction: relevance to aging, neurodegenerative disorders and longevity. Neurochemical Research, 26 (6). pp. 739-64. ISSN 0364-3190

glioma

Daley, E. and Wilkie, D. and Loesch, A. and Hargreaves, I. P. and Kendall, D. A. and Pilkington, G. J. and Bates, T. E. (2005) Chlorimipramine: a novel anticancer agent with a mitochondrial target. Biochemical and Biophysical Research Communications, 328 (2). pp. 623-632. ISSN 0006-291X

glutamate

Rosin, Claudia and Bates, Timothy E. and Skaper, Stephen D. (2004) Excitatory amino acid induced oligodendrocyte cell death in vitro: receptor-dependent and -independent mechanisms. Journal of Neurochemistry, 90 (5). pp. 1173-1185. ISSN 0022-3042

glutamate toxicity

Rosin, Claudia and Colombo, Sergio and Calver, Andrew A. and Bates, Timothy E. and Skaper, Stephen D. (2005) Dopamine D2 and D3 receptor agonists limit oligodendrocyte injury caused by glutamate oxidative stress and oxygen/glucose deprivation. Glia, 52 (4). pp. 336-343. ISSN 0894-1491

glutathione

Calabrese, Vittorio and Testa, Guiseppe and Ravagna, Agrippino and Bates, Timothy Edward and Stella, Anna Maria (2000) HSP70 induction in the brain following ethanol administration in the rat: regulation by glutathione redox state. Biochemical and Biophysical Research Communications, 269 (2). pp. 397-400. ISSN 0006-291X

glutatione

Brooks, Keith J and Hargreaves, Iain and Bhakoo, Kishore and Sellwood, Mark and O'Brien, Francis and Noone, Martina and Sakata, Yasuko and Cady, Ernest and Wylezinska, Marzena and Thornton, John and Ordidge, Roger and Nguyen, Quyen and Clemence, Matthew and Wyatt, John and Bates, Timothy E. (2002) Delayed hypothermia prevents decreases in N-acetylaspartate and reduced glutathione in the cerebral cortex of the neonatal pig following transient hypoxia-ischaemia. Neurochemical Research, 27 (12). pp. 1599-604. ISSN 0364-3190

heat

Tew, G. A. and Saxton, J. M. and Klonizakis, Markos and Moss, J. and Ruddock, A. D. and Hodges, G. J. (2011) Aging and aerobic fitness affect the contribution of noradrenergic sympathetic nerves to the rapid cutaneous vasodilator response to local heating. Journal of Applied Physiology, 110 (5). pp. 1264-1270. ISSN 8750-7587

heat Stress

Sammut, Ivan A. and Jayakumar, Jay and Latif, Najmi and Rothery, Stephen and Severs, Nicholas J. and Smolenski, Ryszard T. and Bates, Timothy E. and Yacoub, Magdi H. (2001) Heat stress contributes to the enhancement of cardiac mitochondrial complex activity. The American Journal of Pathology, 158 (5). pp. 1821-31. ISSN 0002-9440

helicase

Biswas, Subhajit and Núñez Miguel, Ricardo and Sukla, Soumi and Field, Hugh J. (2009) A mutation in helicase motif IV of herpes simplex virus type 1 UL5 that results in reduced growth in vitro and lower virulence in a murine infection model is related to the predicted helicase structure. Journal of General Virology, 90 (8). pp. 1937-1942. ISSN 0022-1317

herpes simplex

Biswas, Subhajit and Núñez Miguel, Ricardo and Sukla, Soumi and Field, Hugh J. (2009) A mutation in helicase motif IV of herpes simplex virus type 1 UL5 that results in reduced growth in vitro and lower virulence in a murine infection model is related to the predicted helicase structure. Journal of General Virology, 90 (8). pp. 1937-1942. ISSN 0022-1317

hydrazine

Kenyon, Susan H. and Waterfield, Catherine J. and Asker, Daniel S. and Kudo, Mariko and Moss, David W. and Bates, Timothy E. and Nicolaou, Anna and Gibbons, William A. and Timbrell, John A. (1999) Effect of hydrazine upon vitamin B12-dependent methionine synthase activity and the sulphur amino acid pathway in isolated rat hepatocytes. Biochemical Pharmacology, 57 (11). pp. 1311-1319. ISSN 0006-2952

hydrogen peroxide

Athanasiou, Andriani and Clarke, Anna B. and Turner, Amy E. and Kumaran, Nethia M. and Vakilpour, Sara and Smith, Paul A. and Bagiokou, Dimitra and Bradshaw, Tracey D. and Westwell, Andrew D. and Fang, Lin and Lobo, Dileep N. and Constantinescu, Cris S. and Calabrese, Vittorio and Loesch, Andrzej and Alexander, Stephen P. H. and Clothier, Richard H. and Kendall, David A. and Bates, Timothy E. (2007) Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications, 364 (1). pp. 131-137. ISSN 0006-291x

hypothermia

Brooks, Keith J and Hargreaves, Iain and Bhakoo, Kishore and Sellwood, Mark and O'Brien, Francis and Noone, Martina and Sakata, Yasuko and Cady, Ernest and Wylezinska, Marzena and Thornton, John and Ordidge, Roger and Nguyen, Quyen and Clemence, Matthew and Wyatt, John and Bates, Timothy E. (2002) Delayed hypothermia prevents decreases in N-acetylaspartate and reduced glutathione in the cerebral cortex of the neonatal pig following transient hypoxia-ischaemia. Neurochemical Research, 27 (12). pp. 1599-604. ISSN 0364-3190

hypoxia

Brooks, K. J. and Clark, J. B. and Bates, T. E. (1996) Assessment of energy metabolism in the developing brain following aglycemic hypoxia by 1H and 31P NMR. Neurochemical Research, 21 (9). pp. 1089-1095. ISSN 0364-3190

Brooks, K. J. and Hargreaves, I. P. and Bates, T. E. (2000) Nitric-oxide-induced inhibition of mitochondrial complexes following aglycaemic hypoxia in neonatal cortical rat brain slices. Developmental Neuroscience, 22 (5-6). pp. 359-65. ISSN 0378-5866

Brooks, Keith J. and Clark, John B. and Bates, Timothy E. (1998) 3-Hydroxybutyrate aids the recovery of the energy state from aglycaemic hypoxia of adult but not neonatal rat brain slices. Journal of Neurochemistry, 70 (5). pp. 1986-1990. ISSN 0022-3042

Keelan, J. and Brand, M. P. and Bates, T. E. and Land, J. M. and Clark, J. B. and Heales, S. J. (1996) Nitric oxide and antioxidant status in glucose and oxygen deprived neonatal and adult rat brain synaptosomes. Neurochemical Research, 21 (8). pp. 923-7. ISSN 0364-3190

Keelan, Julie and Bates, Timothy E. and Clark, John B. (1996) Intrasynaptosomal free calcium concentration during rat brain development: effects of hypoxia, aglycaemia, and ischaemia. Journal of neurochemistry, 66 (6). pp. 2460-7. ISSN 0022-3042

ischemia

Canevari, Laura and Kuroda, Satoshi and Bates, Timothy E. and Clark, John B. and Siesjö, Bo K. (1997) Activity of mitochondrial respiratory chain enzymes after transient focal ischemia in the rat. Journal of Cerebral Blood Flow and Metabolism : official Journal of the International Society of Cerebral Blood Flow and Metabolism, 17 (11). pp. 1166-9. ISSN 0271-678X

Keelan, Julie and Bates, Timothy E. and Clark, John B. (1999) Heightened resistance of the neonatal brain to ischemia-reperfusion involves a lack of mitochondrial damage in the nerve terminal. Brain research, 821 (1). pp. 124-33. ISSN 0006-8993

kainate

Rosin, Claudia and Bates, Timothy E. and Skaper, Stephen D. (2004) Excitatory amino acid induced oligodendrocyte cell death in vitro: receptor-dependent and -independent mechanisms. Journal of Neurochemistry, 90 (5). pp. 1173-1185. ISSN 0022-3042

kidney

Calabrese, V. and Scapagnini, G. and Catalano, C. and Dinotta, F. and Bates, T. E. and Calvani, M. and Stella, A. M. (2001) Effects of acetyl-L-carnitine on the formation of fatty acid ethyl esters in brain and peripheral organs after short-term ethanol administration in rat. Neurochemical Research, 26 (2). pp. 167-74. ISSN 0364-3190

Sammut, I A and Burton, K and Balogun, E and Sarathchandra, P and Brooks, K J and Bates, T E and Green, C J (2000) Time-dependent impairment of mitochondrial function after storage and transplantation of rabbit kidneys. Transplantation, 69 (7). pp. 1265-75. ISSN 0041-1337

laser Doppler flowmetry

Tew, Garry A. and Klonizakis, Markos and Crank, Helen and Briers, J. David and Hodges, Gary J. (2011) Comparison of laser speckle contrast imaging with laser Doppler for assessing microvascular function. Microvascular Research, 82 (3). pp. 326-332. ISSN 0026-2862

liver

Calabrese, V. and Scapagnini, G. and Catalano, C. and Dinotta, F. and Bates, T. E. and Calvani, M. and Stella, A. M. (2001) Effects of acetyl-L-carnitine on the formation of fatty acid ethyl esters in brain and peripheral organs after short-term ethanol administration in rat. Neurochemical Research, 26 (2). pp. 167-74. ISSN 0364-3190

longevity

Calabrese, V. and Scapagnini, G. and Giuffrida Stella, A. M. and Bates, T. E. and Clark, J. B. (2001) Mitochondrial involvement in brain function and dysfunction: relevance to aging, neurodegenerative disorders and longevity. Neurochemical Research, 26 (6). pp. 739-64. ISSN 0364-3190

lung cancer

Athanasiou, Andriani and Smith, Paul A. and Vakilpour, Sara and Kumaran, Nethia M. and Turner, Amy E. and Bagiokou, Dimitra and Layfield, Robert and Ray, David E. and Westwell, Andrew D. and Alexander, Stephen P. H. and Kendall, David A. and Lobo, Dileep N. and Watson, Susan A. and Lophatanon, Artitaya and Muir, Kenneth A. and Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

malic enzyme

Bakken, Inger J. and Sonnewald, Ursula and Clark, John B. and Bates, Timothy E. (1997) [U-13C]glutamate metabolism in rat brain mitochondria reveals malic enzyme activity. Neuroreport, 8 (7). pp. 1567-1570. ISSN 0959-4965

manganese [III] tetrakis 4-benzoic acid porphyrin

Brooks, Keith J. and Hargreaves, Iain P. and Bates, Timothy E. (2008) Protection of respiratory chain enzymes from ischaemic damage in adult rat brain slices. Neurochemical research, 33 (9). pp. 1711-1716. ISSN 0364-3190

methionine synthase

Kenyon, Susan H. and Waterfield, Catherine J. and Asker, Daniel S. and Kudo, Mariko and Moss, David W. and Bates, Timothy E. and Nicolaou, Anna and Gibbons, William A. and Timbrell, John A. (1999) Effect of hydrazine upon vitamin B12-dependent methionine synthase activity and the sulphur amino acid pathway in isolated rat hepatocytes. Biochemical Pharmacology, 57 (11). pp. 1311-1319. ISSN 0006-2952

microglia

Moss, David W. and Bates, Timothy E. (2001) Activation of murine microglial cell lines by lipopolysaccharide and interferon-gamma causes NO-mediated decreases in mitochondrial and cellular function. The European Journal of Neuroscience, 13 (3). pp. 529-38. ISSN 0953-816X

mitochondria

Almeida, A. and Brooks, K. J. and Sammut, I. and Keelan, J. and Davey, G. P. and Clark, J. B. and Bates, T. E. (1995) Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain. Developmental Neuroscience, 17 (4). pp. 212-218. ISSN 0378-5866

Athanasiou, Andriani and Clarke, Anna B. and Turner, Amy E. and Kumaran, Nethia M. and Vakilpour, Sara and Smith, Paul A. and Bagiokou, Dimitra and Bradshaw, Tracey D. and Westwell, Andrew D. and Fang, Lin and Lobo, Dileep N. and Constantinescu, Cris S. and Calabrese, Vittorio and Loesch, Andrzej and Alexander, Stephen P. H. and Clothier, Richard H. and Kendall, David A. and Bates, Timothy E. (2007) Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications, 364 (1). pp. 131-137. ISSN 0006-291x

Athanasiou, Andriani and Smith, Paul A. and Vakilpour, Sara and Kumaran, Nethia M. and Turner, Amy E. and Bagiokou, Dimitra and Layfield, Robert and Ray, David E. and Westwell, Andrew D. and Alexander, Stephen P. H. and Kendall, David A. and Lobo, Dileep N. and Watson, Susan A. and Lophatanon, Artitaya and Muir, Kenneth A. and Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

Bakken, Inger J. and Sonnewald, Ursula and Clark, John B. and Bates, Timothy E. (1997) [U-13C]glutamate metabolism in rat brain mitochondria reveals malic enzyme activity. Neuroreport, 8 (7). pp. 1567-1570. ISSN 0959-4965

Bates, T E and Almeida, A and Heales, S J and Clark, J B (1994) Postnatal development of the complexes of the electron transport chain in isolated rat brain mitochondria. Developmental neuroscience, 16 (5-6). pp. 321-7. ISSN 0378-5866

Calabrese, V. and Scapagnini, G. and Giuffrida Stella, A. M. and Bates, T. E. and Clark, J. B. (2001) Mitochondrial involvement in brain function and dysfunction: relevance to aging, neurodegenerative disorders and longevity. Neurochemical Research, 26 (6). pp. 739-64. ISSN 0364-3190

Cooper, Chris E. and Davies, Nathan A. and Psychoulis, Minas and Canevari, Laura and Bates, Tim E. and Dobbie, Michael S. and Casley, Christopher S. and Sharpe, Martyn A. (2003) Nitric oxide and peroxynitrite cause irreversible increases in the K(m) for oxygen of mitochondrial cytochrome oxidase: in vitro and in vivo studies. Biochimica et Biophysica Acta: general subjects, 1607 (1). pp. 27-34. ISSN 0006-3002

Keelan, Julie and Bates, Timothy E. and Clark, John B. (1999) Heightened resistance of the neonatal brain to ischemia-reperfusion involves a lack of mitochondrial damage in the nerve terminal. Brain research, 821 (1). pp. 124-33. ISSN 0006-8993

Kristián, Tibor and Gertsch, Jeff and Bates, Timothy E. and Siesjö, Bo K. (2000) Characteristics of the calcium-triggered mitochondrial permeability transition in nonsynaptic brain mitochondria: effect of cyclosporin A and ubiquinone O. Journal of Neurochemistry, 74 (5). pp. 1999-2009. ISSN 0022-3042

Kristián, Tibor and Weatherby, Tina M. and Bates, Timothy E. and Fiskum, Gary (2002) Heterogeneity of the calcium-induced permeability transition in isolated non-synaptic brain mitochondria. Journal of Neurochemistry, 83 (6). pp. 1297-308. ISSN 0022-3042

Kuroda, Satoshi and Katsura, Ken-ichiro and Hillered, Lars and Bates, Timothy E. and Siesjö, Bo K. (1996) Delayed treatment with alpha-phenyl-N-tert-butyl nitrone (PBN) attenuates secondary mitochondrial dysfunction after transient focal cerebral ischemia in the rat. Neurobiology of Disease, 3 (2). pp. 149-157. ISSN 0969-9961

Mancuso, Cesare and Bates, Timothy E. and Butterfield, D. Allan and Calafato, Stella and Cornelius, Carolin and De Lorenzo, Antonino and Dinkova Kostova, Albena T. and Calabrese, Vittorio (2007) Natural antioxidants in Alzheimer's disease. Expert Opinion on Investigational Drugs, 16 (12). pp. 1921-1931. ISSN 1354-3784

Sammut, I A and Burton, K and Balogun, E and Sarathchandra, P and Brooks, K J and Bates, T E and Green, C J (2000) Time-dependent impairment of mitochondrial function after storage and transplantation of rabbit kidneys. Transplantation, 69 (7). pp. 1265-75. ISSN 0041-1337

Sammut, Ivan A. and Jayakumar, Jay and Latif, Najmi and Rothery, Stephen and Severs, Nicholas J. and Smolenski, Ryszard T. and Bates, Timothy E. and Yacoub, Magdi H. (2001) Heat stress contributes to the enhancement of cardiac mitochondrial complex activity. The American Journal of Pathology, 158 (5). pp. 1821-31. ISSN 0002-9440

mitochondrial complexes

Athanasiou, Andriani and Clarke, Anna B. and Turner, Amy E. and Kumaran, Nethia M. and Vakilpour, Sara and Smith, Paul A. and Bagiokou, Dimitra and Bradshaw, Tracey D. and Westwell, Andrew D. and Fang, Lin and Lobo, Dileep N. and Constantinescu, Cris S. and Calabrese, Vittorio and Loesch, Andrzej and Alexander, Stephen P. H. and Clothier, Richard H. and Kendall, David A. and Bates, Timothy E. (2007) Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications, 364 (1). pp. 131-137. ISSN 0006-291x

mitochondrial membrane potential

Athanasiou, Andriani and Clarke, Anna B. and Turner, Amy E. and Kumaran, Nethia M. and Vakilpour, Sara and Smith, Paul A. and Bagiokou, Dimitra and Bradshaw, Tracey D. and Westwell, Andrew D. and Fang, Lin and Lobo, Dileep N. and Constantinescu, Cris S. and Calabrese, Vittorio and Loesch, Andrzej and Alexander, Stephen P. H. and Clothier, Richard H. and Kendall, David A. and Bates, Timothy E. (2007) Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications, 364 (1). pp. 131-137. ISSN 0006-291x

mitochondris

Canevari, Laura and Kuroda, Satoshi and Bates, Timothy E. and Clark, John B. and Siesjö, Bo K. (1997) Activity of mitochondrial respiratory chain enzymes after transient focal ischemia in the rat. Journal of Cerebral Blood Flow and Metabolism : official Journal of the International Society of Cerebral Blood Flow and Metabolism, 17 (11). pp. 1166-9. ISSN 0271-678X

mouse infection model

Biswas, Subhajit and Núñez Miguel, Ricardo and Sukla, Soumi and Field, Hugh J. (2009) A mutation in helicase motif IV of herpes simplex virus type 1 UL5 that results in reduced growth in vitro and lower virulence in a murine infection model is related to the predicted helicase structure. Journal of General Virology, 90 (8). pp. 1937-1942. ISSN 0022-1317

multiple sclerosis

Calabrese, Vittorio and Scapagnini, Giovanni and Ravagna, Agrippino and Bella, Rita and Foresti, Roberta and Bates, Timothy E. and Giuffrida Stella, Anna-Maria and Pennisi, Giovanni (2002) Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels. Journal of Neuroscience Research, 70 (4). pp. 580-7. ISSN 0360-4012

Rosin, Claudia and Bates, Timothy E. and Skaper, Stephen D. (2004) Excitatory amino acid induced oligodendrocyte cell death in vitro: receptor-dependent and -independent mechanisms. Journal of Neurochemistry, 90 (5). pp. 1173-1185. ISSN 0022-3042

mutation

Biswas, Subhajit and Núñez Miguel, Ricardo and Sukla, Soumi and Field, Hugh J. (2009) A mutation in helicase motif IV of herpes simplex virus type 1 UL5 that results in reduced growth in vitro and lower virulence in a murine infection model is related to the predicted helicase structure. Journal of General Virology, 90 (8). pp. 1937-1942. ISSN 0022-1317

necrosis

Athanasiou, Andriani and Smith, Paul A. and Vakilpour, Sara and Kumaran, Nethia M. and Turner, Amy E. and Bagiokou, Dimitra and Layfield, Robert and Ray, David E. and Westwell, Andrew D. and Alexander, Stephen P. H. and Kendall, David A. and Lobo, Dileep N. and Watson, Susan A. and Lophatanon, Artitaya and Muir, Kenneth A. and Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

neonatal

Brooks, K. J. and Hargreaves, I. P. and Bates, T. E. (2000) Nitric-oxide-induced inhibition of mitochondrial complexes following aglycaemic hypoxia in neonatal cortical rat brain slices. Developmental Neuroscience, 22 (5-6). pp. 359-65. ISSN 0378-5866

Brooks, K. J. and Hargreaves, I. P. and Clark, J. B. and Bates, Timothy (1998) Ischaemia-induced damage to mitochondrial complexes in the neonatal brain--role of NO. Biochemical Society Transactions, 26 (4). S343. ISSN 0300-5127

Brooks, Keith J and Hargreaves, Iain and Bhakoo, Kishore and Sellwood, Mark and O'Brien, Francis and Noone, Martina and Sakata, Yasuko and Cady, Ernest and Wylezinska, Marzena and Thornton, John and Ordidge, Roger and Nguyen, Quyen and Clemence, Matthew and Wyatt, John and Bates, Timothy E. (2002) Delayed hypothermia prevents decreases in N-acetylaspartate and reduced glutathione in the cerebral cortex of the neonatal pig following transient hypoxia-ischaemia. Neurochemical Research, 27 (12). pp. 1599-604. ISSN 0364-3190

Keelan, Julie and Bates, Timothy E. and Clark, John B. (1999) Heightened resistance of the neonatal brain to ischemia-reperfusion involves a lack of mitochondrial damage in the nerve terminal. Brain research, 821 (1). pp. 124-33. ISSN 0006-8993

neurodegeneration

Calabrese, V. and Bates, T. E. and Stella, A. M. (2000) NO synthase and NO-dependent signal pathways in brain aging and neurodegenerative disorders: the role of oxidant/antioxidant balance. Neurochemical Research, 25 (9-10). pp. 1315-41. ISSN 0364-3190

Calabrese, V. and Scapagnini, G. and Giuffrida Stella, A. M. and Bates, T. E. and Clark, J. B. (2001) Mitochondrial involvement in brain function and dysfunction: relevance to aging, neurodegenerative disorders and longevity. Neurochemical Research, 26 (6). pp. 739-64. ISSN 0364-3190

Calabrese, Vittorio and Cornelius, Carolin and Mancuso, Cesare and Pennisi, Giovanni and Calafato, Stella and Bellia, Francesco and Bates, Timothy E. and Giuffrida Stella, Anna Maria and Schapira, Tony and Dinkova Kostova, Albena T. and Rizzarelli, Enrico (2008) Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity. Neurochemical Research, 33 (12). pp. 2444-2471. ISSN 0364-3190

neuroprotection

Calabrese, Vittorio and Cornelius, Carolin and Mancuso, Cesare and Pennisi, Giovanni and Calafato, Stella and Bellia, Francesco and Bates, Timothy E. and Giuffrida Stella, Anna Maria and Schapira, Tony and Dinkova Kostova, Albena T. and Rizzarelli, Enrico (2008) Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity. Neurochemical Research, 33 (12). pp. 2444-2471. ISSN 0364-3190

nitric oxide

Brooks, K. J. and Hargreaves, I. P. and Bates, T. E. (2000) Nitric-oxide-induced inhibition of mitochondrial complexes following aglycaemic hypoxia in neonatal cortical rat brain slices. Developmental Neuroscience, 22 (5-6). pp. 359-65. ISSN 0378-5866

Brooks, K. J. and Hargreaves, I. P. and Clark, J. B. and Bates, Timothy (1998) Ischaemia-induced damage to mitochondrial complexes in the neonatal brain--role of NO. Biochemical Society Transactions, 26 (4). S343. ISSN 0300-5127

Calabrese, V. and Bates, T. E. and Stella, A. M. (2000) NO synthase and NO-dependent signal pathways in brain aging and neurodegenerative disorders: the role of oxidant/antioxidant balance. Neurochemical Research, 25 (9-10). pp. 1315-41. ISSN 0364-3190

Keelan, J. and Brand, M. P. and Bates, T. E. and Land, J. M. and Clark, J. B. and Heales, S. J. (1996) Nitric oxide and antioxidant status in glucose and oxygen deprived neonatal and adult rat brain synaptosomes. Neurochemical Research, 21 (8). pp. 923-7. ISSN 0364-3190

Tew, G. and Klonizakis, Markos and Moss, J. and Ruddock, A. D. and Saxton, J. M. and Hodges, G. J. (2011) Role of sensory nerves in the rapid cutaneous vasodilator response to local heating in young and older endurance-trained and untrained men. Experimental Physiology, 96 (2). pp. 163-170. ISSN 0958-0670

nitrotyrosine

Calabrese, Vittorio and Scapagnini, Giovanni and Ravagna, Agrippino and Bella, Rita and Foresti, Roberta and Bates, Timothy E. and Giuffrida Stella, Anna-Maria and Pennisi, Giovanni (2002) Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels. Journal of Neuroscience Research, 70 (4). pp. 580-7. ISSN 0360-4012

nutrition

Calabrese, Vittorio and Cornelius, Carolin and Mancuso, Cesare and Pennisi, Giovanni and Calafato, Stella and Bellia, Francesco and Bates, Timothy E. and Giuffrida Stella, Anna Maria and Schapira, Tony and Dinkova Kostova, Albena T. and Rizzarelli, Enrico (2008) Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity. Neurochemical Research, 33 (12). pp. 2444-2471. ISSN 0364-3190

oligodendrocyte

Rosin, Claudia and Bates, Timothy E. and Skaper, Stephen D. (2004) Excitatory amino acid induced oligodendrocyte cell death in vitro: receptor-dependent and -independent mechanisms. Journal of Neurochemistry, 90 (5). pp. 1173-1185. ISSN 0022-3042

Rosin, Claudia and Colombo, Sergio and Calver, Andrew A. and Bates, Timothy E. and Skaper, Stephen D. (2005) Dopamine D2 and D3 receptor agonists limit oligodendrocyte injury caused by glutamate oxidative stress and oxygen/glucose deprivation. Glia, 52 (4). pp. 336-343. ISSN 0894-1491

oxidative stress

Bates, T. E. and Heales, S. J. and Davies, S. E. and Boakye, P. and Clark, J. B. (1994) Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. Journal of neurochemistry, 63 (2). pp. 640-648. ISSN 0022-3042

Rosin, Claudia and Bates, Timothy E. and Skaper, Stephen D. (2004) Excitatory amino acid induced oligodendrocyte cell death in vitro: receptor-dependent and -independent mechanisms. Journal of Neurochemistry, 90 (5). pp. 1173-1185. ISSN 0022-3042

perfusion

Klonizakis, Markos (2012) Studying the cutaneous microcirculatory response during upper-limb exercise in healthy, older, sedentary people. Clinical Hemorheology and Microcirculation, 51 (1). pp. 69-75. ISSN 1386-0281

permeability transition pore

Kristián, Tibor and Gertsch, Jeff and Bates, Timothy E. and Siesjö, Bo K. (2000) Characteristics of the calcium-triggered mitochondrial permeability transition in nonsynaptic brain mitochondria: effect of cyclosporin A and ubiquinone O. Journal of Neurochemistry, 74 (5). pp. 1999-2009. ISSN 0022-3042

Kristián, Tibor and Weatherby, Tina M. and Bates, Timothy E. and Fiskum, Gary (2002) Heterogeneity of the calcium-induced permeability transition in isolated non-synaptic brain mitochondria. Journal of Neurochemistry, 83 (6). pp. 1297-308. ISSN 0022-3042

peroxynitrite

Brooks, Keith J. and Hargreaves, Iain P. and Bates, Timothy E. (2008) Protection of respiratory chain enzymes from ischaemic damage in adult rat brain slices. Neurochemical research, 33 (9). pp. 1711-1716. ISSN 0364-3190

Calabrese, Vittorio and Scapagnini, Giovanni and Ravagna, Agrippino and Bella, Rita and Foresti, Roberta and Bates, Timothy E. and Giuffrida Stella, Anna-Maria and Pennisi, Giovanni (2002) Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels. Journal of Neuroscience Research, 70 (4). pp. 580-7. ISSN 0360-4012

Cooper, Chris E. and Davies, Nathan A. and Psychoulis, Minas and Canevari, Laura and Bates, Tim E. and Dobbie, Michael S. and Casley, Christopher S. and Sharpe, Martyn A. (2003) Nitric oxide and peroxynitrite cause irreversible increases in the K(m) for oxygen of mitochondrial cytochrome oxidase: in vitro and in vivo studies. Biochimica et Biophysica Acta: general subjects, 1607 (1). pp. 27-34. ISSN 0006-3002

Moss, David W. and Bates, Timothy E. (2001) Activation of murine microglial cell lines by lipopolysaccharide and interferon-gamma causes NO-mediated decreases in mitochondrial and cellular function. The European Journal of Neuroscience, 13 (3). pp. 529-38. ISSN 0953-816X

phospholipid

Murphy, Elizabeth J. and Bates, Timothy E. and Williams, Stephen R. and Watson, Tracey and Brindle, Kevin M. and Rajagopalan, Bheeshma and Radda, George K. (1992) Endoplasmic reticulum: the major contributor to the PDE peak in hepatic 31P-NMR spectra at low magnetic field strengths. Biochimica et biophysica acta: biomembranes, 1111 (1). pp. 51-58. ISSN 0005-2736

presenilin-1

Pardon, Marie-Christine and Sarmad, Sarir and Rattray, Ivan and Bates, Timothy E. and Scullion, Gillian A. and Marsden, Charles A. and Barrett, David A. and Lowe, James and Kendall, David A. (2009) Repeated novel cage exposure-induced improvement of early Alzheimer's-like cognitive and amyloid changes in TASTPM mice is unrelated to changes in brain endocannabinoids levels. Neurobiology of Aging, 30 (7). pp. 1099-1113. ISSN 0197-4580

primase

Biswas, Subhajit and Núñez Miguel, Ricardo and Sukla, Soumi and Field, Hugh J. (2009) A mutation in helicase motif IV of herpes simplex virus type 1 UL5 that results in reduced growth in vitro and lower virulence in a murine infection model is related to the predicted helicase structure. Journal of General Virology, 90 (8). pp. 1937-1942. ISSN 0022-1317

prostate cancer

Dagnelie, P. C. and Bell, J. D. and Williams, S. C. and Bates, T. E. and Abel, P. D. and Foster, C. S. (1993) Altered phosphorylation status, phospholipid metabolism and gluconeogenesis in the host liver of rats with prostate cancer: a 31P magnetic resonance spectroscopy study. British Journal of Cancer, 67 (6). pp. 1303-1309. ISSN 0007-0920

reactivity

Tew, Garry A. and Klonizakis, Markos and Crank, Helen and Briers, J. David and Hodges, Gary J. (2011) Comparison of laser speckle contrast imaging with laser Doppler for assessing microvascular function. Microvascular Research, 82 (3). pp. 326-332. ISSN 0026-2862

redox

Calabrese, Vittorio and Testa, Guiseppe and Ravagna, Agrippino and Bates, Timothy Edward and Stella, Anna Maria (2000) HSP70 induction in the brain following ethanol administration in the rat: regulation by glutathione redox state. Biochemical and Biophysical Research Communications, 269 (2). pp. 397-400. ISSN 0006-291X

redox homeostasis

Calabrese, Vittorio and Cornelius, Carolin and Mancuso, Cesare and Pennisi, Giovanni and Calafato, Stella and Bellia, Francesco and Bates, Timothy E. and Giuffrida Stella, Anna Maria and Schapira, Tony and Dinkova Kostova, Albena T. and Rizzarelli, Enrico (2008) Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity. Neurochemical Research, 33 (12). pp. 2444-2471. ISSN 0364-3190

redox state

Calabrese, Vittorio and Cornelius, Carolin and Mancuso, Cesare and Pennisi, Giovanni and Calafato, Stella and Bellia, Francesco and Bates, Timothy E. and Giuffrida Stella, Anna Maria and Schapira, Tony and Dinkova Kostova, Albena T. and Rizzarelli, Enrico (2008) Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity. Neurochemical Research, 33 (12). pp. 2444-2471. ISSN 0364-3190

redox-dependent

Mancuso, Cesare and Bates, Timothy E. and Butterfield, D. Allan and Calafato, Stella and Cornelius, Carolin and De Lorenzo, Antonino and Dinkova Kostova, Albena T. and Calabrese, Vittorio (2007) Natural antioxidants in Alzheimer's disease. Expert Opinion on Investigational Drugs, 16 (12). pp. 1921-1931. ISSN 1354-3784

ref03

Biswas, Subhajit and Núñez Miguel, Ricardo and Sukla, Soumi and Field, Hugh J. (2009) A mutation in helicase motif IV of herpes simplex virus type 1 UL5 that results in reduced growth in vitro and lower virulence in a murine infection model is related to the predicted helicase structure. Journal of General Virology, 90 (8). pp. 1937-1942. ISSN 0022-1317

Brooks, Keith J. and Hargreaves, Iain P. and Bates, Timothy E. (2008) Protection of respiratory chain enzymes from ischaemic damage in adult rat brain slices. Neurochemical research, 33 (9). pp. 1711-1716. ISSN 0364-3190

Pardon, Marie-Christine and Sarmad, Sarir and Rattray, Ivan and Bates, Timothy E. and Scullion, Gillian A. and Marsden, Charles A. and Barrett, David A. and Lowe, James and Kendall, David A. (2009) Repeated novel cage exposure-induced improvement of early Alzheimer's-like cognitive and amyloid changes in TASTPM mice is unrelated to changes in brain endocannabinoids levels. Neurobiology of Aging, 30 (7). pp. 1099-1113. ISSN 0197-4580

refdoi

Biswas, Subhajit and Núñez Miguel, Ricardo and Sukla, Soumi and Field, Hugh J. (2009) A mutation in helicase motif IV of herpes simplex virus type 1 UL5 that results in reduced growth in vitro and lower virulence in a murine infection model is related to the predicted helicase structure. Journal of General Virology, 90 (8). pp. 1937-1942. ISSN 0022-1317

Brooks, Keith J. and Hargreaves, Iain P. and Bates, Timothy E. (2008) Protection of respiratory chain enzymes from ischaemic damage in adult rat brain slices. Neurochemical research, 33 (9). pp. 1711-1716. ISSN 0364-3190

Pardon, Marie-Christine and Sarmad, Sarir and Rattray, Ivan and Bates, Timothy E. and Scullion, Gillian A. and Marsden, Charles A. and Barrett, David A. and Lowe, James and Kendall, David A. (2009) Repeated novel cage exposure-induced improvement of early Alzheimer's-like cognitive and amyloid changes in TASTPM mice is unrelated to changes in brain endocannabinoids levels. Neurobiology of Aging, 30 (7). pp. 1099-1113. ISSN 0197-4580

reliability

Tew, Garry A. and Klonizakis, Markos and Crank, Helen and Briers, J. David and Hodges, Gary J. (2011) Comparison of laser speckle contrast imaging with laser Doppler for assessing microvascular function. Microvascular Research, 82 (3). pp. 326-332. ISSN 0026-2862

reperfusion

Brooks, Keith J and Hargreaves, Iain and Bhakoo, Kishore and Sellwood, Mark and O'Brien, Francis and Noone, Martina and Sakata, Yasuko and Cady, Ernest and Wylezinska, Marzena and Thornton, John and Ordidge, Roger and Nguyen, Quyen and Clemence, Matthew and Wyatt, John and Bates, Timothy E. (2002) Delayed hypothermia prevents decreases in N-acetylaspartate and reduced glutathione in the cerebral cortex of the neonatal pig following transient hypoxia-ischaemia. Neurochemical Research, 27 (12). pp. 1599-604. ISSN 0364-3190

resiniferatoxin

Athanasiou, Andriani and Smith, Paul A. and Vakilpour, Sara and Kumaran, Nethia M. and Turner, Amy E. and Bagiokou, Dimitra and Layfield, Robert and Ray, David E. and Westwell, Andrew D. and Alexander, Stephen P. H. and Kendall, David A. and Lobo, Dileep N. and Watson, Susan A. and Lophatanon, Artitaya and Muir, Kenneth A. and Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

resistance

Biswas, Subhajit and Núñez Miguel, Ricardo and Sukla, Soumi and Field, Hugh J. (2009) A mutation in helicase motif IV of herpes simplex virus type 1 UL5 that results in reduced growth in vitro and lower virulence in a murine infection model is related to the predicted helicase structure. Journal of General Virology, 90 (8). pp. 1937-1942. ISSN 0022-1317

respiratory chain complexes

Brooks, Keith J. and Hargreaves, Iain P. and Bates, Timothy E. (2008) Protection of respiratory chain enzymes from ischaemic damage in adult rat brain slices. Neurochemical research, 33 (9). pp. 1711-1716. ISSN 0364-3190

resveratrol

Mancuso, Cesare and Bates, Timothy E. and Butterfield, D. Allan and Calafato, Stella and Cornelius, Carolin and De Lorenzo, Antonino and Dinkova Kostova, Albena T. and Calabrese, Vittorio (2007) Natural antioxidants in Alzheimer's disease. Expert Opinion on Investigational Drugs, 16 (12). pp. 1921-1931. ISSN 1354-3784

schizophrenia

Rosin, Claudia and Colombo, Sergio and Calver, Andrew A. and Bates, Timothy E. and Skaper, Stephen D. (2005) Dopamine D2 and D3 receptor agonists limit oligodendrocyte injury caused by glutamate oxidative stress and oxygen/glucose deprivation. Glia, 52 (4). pp. 336-343. ISSN 0894-1491

skin

Tew, Garry A. and Klonizakis, Markos and Crank, Helen and Briers, J. David and Hodges, Gary J. (2011) Comparison of laser speckle contrast imaging with laser Doppler for assessing microvascular function. Microvascular Research, 82 (3). pp. 326-332. ISSN 0026-2862

skin blood flow

Tew, G. and Klonizakis, Markos and Moss, J. and Ruddock, A. D. and Saxton, J. M. and Hodges, G. J. (2011) Role of sensory nerves in the rapid cutaneous vasodilator response to local heating in young and older endurance-trained and untrained men. Experimental Physiology, 96 (2). pp. 163-170. ISSN 0958-0670

Tew, G. and Klonizakis, Markos and Saxton, G. (2010) Effects of ageing and fitness on skin-microvessel vasodilator function in humans. European Journal of Applied Physiology, 109 (2). pp. 173-181. ISSN 1439-6319

skin temperature

Klonizakis, Markos (2012) Studying the cutaneous microcirculatory response during upper-limb exercise in healthy, older, sedentary people. Clinical Hemorheology and Microcirculation, 51 (1). pp. 69-75. ISSN 1386-0281

storage

Sammut, I A and Burton, K and Balogun, E and Sarathchandra, P and Brooks, K J and Bates, T E and Green, C J (2000) Time-dependent impairment of mitochondrial function after storage and transplantation of rabbit kidneys. Transplantation, 69 (7). pp. 1265-75. ISSN 0041-1337

superoxide dismutase

Brooks, Keith J. and Hargreaves, Iain P. and Bates, Timothy E. (2008) Protection of respiratory chain enzymes from ischaemic damage in adult rat brain slices. Neurochemical research, 33 (9). pp. 1711-1716. ISSN 0364-3190

training

Tew, G. and Klonizakis, Markos and Moss, J. and Ruddock, A. D. and Saxton, J. M. and Hodges, G. J. (2011) Role of sensory nerves in the rapid cutaneous vasodilator response to local heating in young and older endurance-trained and untrained men. Experimental Physiology, 96 (2). pp. 163-170. ISSN 0958-0670

tricyclic

Daley, E. and Wilkie, D. and Loesch, A. and Hargreaves, I. P. and Kendall, D. A. and Pilkington, G. J. and Bates, T. E. (2005) Chlorimipramine: a novel anticancer agent with a mitochondrial target. Biochemical and Biophysical Research Communications, 328 (2). pp. 623-632. ISSN 0006-291X

ubiquinone

Kristián, Tibor and Gertsch, Jeff and Bates, Timothy E. and Siesjö, Bo K. (2000) Characteristics of the calcium-triggered mitochondrial permeability transition in nonsynaptic brain mitochondria: effect of cyclosporin A and ubiquinone O. Journal of Neurochemistry, 74 (5). pp. 1999-2009. ISSN 0022-3042

virus

Biswas, Subhajit and Núñez Miguel, Ricardo and Sukla, Soumi and Field, Hugh J. (2009) A mutation in helicase motif IV of herpes simplex virus type 1 UL5 that results in reduced growth in vitro and lower virulence in a murine infection model is related to the predicted helicase structure. Journal of General Virology, 90 (8). pp. 1937-1942. ISSN 0022-1317

vitagenes

Mancuso, Cesare and Bates, Timothy E. and Butterfield, D. Allan and Calafato, Stella and Cornelius, Carolin and De Lorenzo, Antonino and Dinkova Kostova, Albena T. and Calabrese, Vittorio (2007) Natural antioxidants in Alzheimer's disease. Expert Opinion on Investigational Drugs, 16 (12). pp. 1921-1931. ISSN 1354-3784

vitamin E

Calabrese, V. and Scapagnini, G. and Catalano, C. and Bates, T. E. and Geraci, D. and Pennisi, G. and Giuffrida Stella, A. M. (2001) Regulation of heat shock protein synthesis in human skin fibroblasts in response to oxidative stress: role of vitamin E. International Journal of Tissue Reactions, 23 (4). pp. 127-35. ISSN 0250-0868