Items where Subject is "A100 Pre-clinical Medicine"

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(E) - capsaicin 1-methyl-4-phenylpyridinium 13C 1H 31P 4 aminobutyric acid AEA AFM AFM-SCFS AME AMPA ATP AZT-TP; NRTI; drug delivery; metal organic framework; nanoparticle Accelerometers Acute Inflammatory Demyelinating Polyneuropathy Adherens Junction Adolescent Adolescents Adult Age Age of Onset Aged Aged, 80 and over Ageing Aging Alleles Allopurinol Alzheimer's Animal Animals Animals, Newborn Antibodies Antibodies, Monoclonal Antibody Formation Antibody Specificity Antigen-Antibody Reactions Antigens Antigens, Surface Antioxidant Antioxidants Anxiety; Chronopharmacology; Depression; Epilepsy; Melatonin Apoptosis Applied Knowledge Test Arabs Article Autoantibodies Autoantigens Autoimmune Diseases Autoimmunity Autoradiography Azo Compounds B lymphocyte BAY 57-1293 BMP9 BMPRII BSO BV2 Bandages Barrett esophagus Base Sequence Belgium Binding Sites, Antibody Binding, Competitive Biological Markers Biomechanics Blood Glucose Body Mass Index Brain Brain Chemistry Brain Slices Brain Tumour Breast Asymmetry Breast Density Breast cancer diagnosis C peptide C reactive protein C-Peptide CALR CD47 Ca2+ Cadherin Calcium Cancer Cancer risk assessment tools Carbohydrates Cathepsin Cell Fractionation Cell Line Cell Membrane Cell Proliferation Cell Transplantation Cell adhesion Cell carrier system Cell carrier system; Cultured melanocytes; Keratinocytes; Surface engineered carriers; Vitiligo grafting Cells, Cultured Cellular stress response Centrifugation, Density Gradient Charge transfer complex Child Child and adolescent mental health services Child, Preschool Chronic Disease Clinical application Cloning, Molecular Coculture techniques Cohort Studies Comparative Study Complex I Complexes Compliance Computer Vision Coxsackie virus Cross Reactions Cross-Sectional Studies Culture techniques Cultured melanocytes Cyclosporine Cytokines Cytoplasm D2 receptor D3 receptor DALY DNA DNA Primers Decision Trees Delta-9-tetrahydrocannabinol Derivatization Development Diabetes Diabetes Mellitus Diabetes Mellitus, Experimental Diabetes Mellitus, Insulin-Dependent Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Diabetes, Gestational Dietary antioxidants Disease Progression Disease Susceptibility Disease prediction Diseases in Twins Dithizone Drug Delivery Dyslexia EM ET EVI1 Electron Microscopy Electron Transport Chain Electrophoresis, Gel, Two-Dimensional Electrophoresis, Polyacrylamide Gel Emotional Distress Endothelial BMPR-II Endothelial cells Endothelial function Epidermis Epilepsy Epitopes Ethnicity Exercise Family Fathers Fatty acide ethyl esters Female Fluorescein Fluorescence quenching Fluorescent Antibody Technique Fluorescent Antibody Technique, Indirect Focal Density Follow-Up Studies Forecasting GATA1 GSH Gene Expression Regulation, Bacterial Genes, MHC Class II Genetic Predisposition to Disease Gerbil Ghana Global Burden Disease Glucagon Glucose Glucose Tolerance Test Glutamate Decarboxylase Glutamate receptors Glutathione Guillain-Barr?yndrome Guillain-Barré Syndrome H202 H460 HIV/AIDS HLA Antigens HLA DQ antigen HLA DR1 antigen HLA DR13 antigen HLA DR3 antigen HLA DR4 antigen HLA DR4 antigen, adult HLA antigen HLA antigen class 1 HLA antigen class 2 HLA antigen class 2, adolescent HLA system HLA-D Antigens HLA-DQ Antigens HLA-DR Antigens HLA-DR3 Antigen HLA-DR4 Antigen HSP 70 HSP's HU 210 Haematological cancers Hand Hygiene Hand hygiene Haplotypes Heart Heat Heat Shock Heat-Shock Proteins Hemoglobin A, Glycosylated Hepatocytes Histocompatibility Antigens Class I Histocompatibility Antigens Class II Homeodomain Proteins Humans Hydrogen peroxide Hydrolysis Hypoglycemic Agents Hypothermia IA 2 antigen IA 2beta antigen IA-2 ICA512 autoantibody IL33 protein, human IPTP Ia 2 antigen Ia antibody Ia antigen Image Processing Immumnoelectron microscopy Immunocytochemistry Immunodominant Epitopes Immunoglobulin G Immunohistochemistry Immunology Immunoprecipitation Immunosorbent Techniques Immunosuppressive Agents Infant Infant, Newborn Infection control Infection prevention and control Insulin Insulin Antibodies Insulin-Secreting Cells Interferon gamma Interleukin-23 Interleukins Iodine Radioisotopes Iontophoresis Ischaemia Ischemia Islets of Langerhans Islets of Langerhans Transplantation Isoenzymes J774 JAK/STAT JCNotOpen JCOpen Keratinocytes Kidney L-buthionine sulfoximine LASCA LDF LPS Laser Doppler flowmetry Laser Doppler fluximetry Lectins Life Tables Lipopolysaccharide Liver MCAO MOF MPN MPP+ MPT Pore MPTP MRCGP MRS Male Mass Screening Melanocytes Membrane Glycoproteins Membrane Proteins Mental health workers Mice Mice, Inbred BALB C Mice, Inbred NOD Mice, SCID Microbial Collagenase Microvascular perfusion Middle Age Middle Aged Miller-Fisher Syndrome or Chronic Inflammatory Demyelinating Polyneuropathy Mitochondria Mitochondrial complexes Models Molecular Sequence Data Molecular Weight Monolayer integrity Mothers Mucositis Mutation N omega-nitro-L-arginine N-Acetylaspartate N-acetylaspartate N11 NAA NMR NMR Spectroscopy NMR spectroscopy NO NOS Nanoparticles Neoplasm Proteins Nerve Tissue Proteins Nitric Oxide Synthase Nitric oxide Nitric oxide synthase NotOAChecked Nuclear Family O-phthalaldehyde Oral Cancer Organ Preservation Solutions Organ Specificity Osmolar Concentration Ovarian Neoplasms Oxidative Phosphorylation Oxidative Stress Oxidative phsphorylation Oxidative stress P2X7 PBN Pancreas Pancreas Transplantation Pancreatic Neoplasms Parkinson's disease Patient experiences Peptide Fragments Peptide Mapping Peptides Perindopril erbumine Perindopril erbumine; Dansyl chloride; Derivatization; Spectrofluorimetry Phosphodiester Placebos Plasmids Polyendocrinopathies, Autoimmune Polymerase Chain Reaction Polymorphism, Genetic Polyvinyl chloride Precipitin Tests Prediabetic State Predictive Value of Tests Pregnancy Pregnancy in Diabetics Prehospital ambulance care Prevalence Preventable mortality Primary care Prospective Studies Prostate cancer Protein Footprinting Protein-Tyrosine-Phosphatase Proteins Pulmonary arterial hypertension QCancer Qualitative Qualitative systematic review and meta-synthesis Quality of care RCT RUNX1 RUNx1 Rabbits Radiation Radioimmunoprecipitation Assay Radioligand Assay Raffinose Rats Rats, Inbred Strains Rats, Wistar Recombinant Fusion Proteins Recombinant Proteins Recombinant Proteins, Escherichia coli Reference Values Registries Regression Analysis Reperfusion Reperfusion injury Reproducibility Reproducibility of Results Respiratory chain Reverse Transcriptase Polymerase Chain Reaction Risk Risk Assessment Risk Factors Running S-nitrosothiols SB366791 SCID mouse SCID mouse, Adenosine Saudi Arabia Saudi Arabia, Adult Sensitivity and Specificity Service Provision Sex Characteristics Sexual health Silicones Single cell PCR Skeletal Muscle Skin blood flow Skin transplantation Social Work Somatostatin Spectrofluorimetry. Stiff-Person Syndrome Sulfur Radioisotopes Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Surface engineered carriers Suspected convulsions Sweden Synaptic Synaptosomal Synaptosomes Systematic review T lymphocyte, Adolescent T-Lymphocytes TASTPM THC TRPV1 Time Factors Tissue Distribution Tissue Survival Tissue and Organ Harvesting Tissue engineering Trandolapril Trans-Activators Transfection Transplantation Trypsin Trypsin, Human herpesvirus 4 Twins, Dizygotic Twins, Monozygotic Type 1 diabetes United Kingdom, Adult Vanilloid Vanilloids Vitiligo Vitiligo grafting Wellbeing Young people acetyl carnitine acetyl-L-carnitine activin A acute myeloid leukaemia adiponectin adult adverse drug reactions aerobic exercise age age distribution aged aging aglycemia algorithm allele ambulance services amino acid amino terminal sequence amyloid amyloid precursor protein anandamide animal animal cell animal experiment animal model animal tissue antibody antibody blood level antibody detection antibody response antibody specificity antibody titer antibody, autoimmunity anticancer antidepressants antidiabetic agent antigen antigen antibody complex antigen antibody reaction antigen binding antigen detection antigen expression antigen presentation antigen recognition antigen specificity antisense cDNA apoptosis arm-cranking exercise article attention autoantibody autoantigen autoantigen, adolescent autoantigen, article autoimmune disease autoimmune polyendocrinopathy autoimmunity autoradiography b lymphocyte betacellulin binding affinity biological marker biosensors biotin blood blood flow blood level blood sampling bmjaccents bmjanomaly bmjdoi bmjgoldcheck body composition brain brain enzyme brain slices busulfan cytotoxicity drug crystallization drug loading drug release iron (III) carboxylate nanoparticle NMR porous MOF c peptide cadherin calcium cancer cancer risk candidiasis cannabinoid capsazepine carboxy terminal sequence cardiac cell activity cell adhesion cell culture cell damage cell differentiation cell fractionation cell growth cell invasion cell isolation cell line cell proliferation cell protein cell survival cell viability cell-cell coupling cellular distribution cellular stress cerebral ischaemia cerebral ischemia cerebroprotection child childhood disease chimera chlorimipramine clinical article clinical trial clomipramine cohort analysis colloids comparative study complementary dna complexexs conference paper controlled clinical trial controlled study cross reaction curcumin cutaneous microcirculation cyclosporin cytochemistry cytochrome oxidase cytokeratin cytokine cytoplasm densitometry density gradient development diabetes diabetes Education competencies diabetes mellitus diagnosis diagnostic value disease association disease course disease duration disease marker disease predisposition dithizone, animal cell dizygotic twins dopamine dopamine receptor drug effects dysfunction eNOS early diagnosis ectodermal dysplasia electron transport chain electrophoresis endocannabinoid endocrine disease endoplasmic reticulum stress enzyme activity enzyme antibody enzymes epitope epitope mapping epstein barr virus escherichia coli esophageal adenocarcinoma ethanol ethnic group etiology excitotoxicity exercise exercise intensity exocrine cell familial disease family family study fatty acids feasibility study female fibroblast fitness fluorescent antibody technique follow up free radicals function gastroesophageal reflux gene gene expression regulation gene mapping genetic marker genetic polymorphism genetic predisposition genetic susceptibility genetic transfection genetics genotype glioma glucagon glucose glucose blood level glucose homeostasis glucose tolerance glucose tolerance test glutamate glutamate decarboxylase glutamate decarboxylase 65 glutamate decarboxylase 65 antibody glutamate decarboxylase, adolescent glutamate toxicity glutathione glutatione glycemic control glycosylated hemoglobin glycosylation gold nanoparticles graves disease hamster haplotype head and neck cancer healthcare heat heat Stress heat shock protein, animal cell helicase herpes simplex high risk patient high risk population histology hormone hormone blood level hospitalization human human cell human cell culture human tissue humoral immunity hybrid protein hydrazine hydrogen peroxide hyperglycemia hypothermia hypoxia ia 2 antibody immune response immunoassay immunoblotting immunocytochemistry immunofluorescence immunofluorescence test immunoglobulin g, article immunohistochemistry immunology immunoprecipitation immunostimulation immunosuppressive agent immunosuppressive treatment impaired glucose tolerance incidence inequalities infant inflammation insulin insulin antibody insulin antibody, adult insulin dependent diabetes mellitus insulin release insulin resistance insulin sensitivity insulin synthesis insulin treatment insulin, adult insulinoma interleukin 22 interleukin 23 interleukin 24 interleukin 33 interleukin 6 interleukin derivative interleukin-22 interleukin-24 interleukin-33, mouse, animal cell iodine 125 ischemia isoenzyme, adolescent isotope labeling jak2 kainate kidney laser Doppler flowmetry leptin life course life table liver longevity low risk of death lung cancer mGlu5 receptors; ventrobasal thalamus; somatosensory cortex; GABA uptake; GAT-1; tonic inhibition. major clinical study male malic enzyme manganese [III] tetrakis 4-benzoic acid porphyrin marker measurement membrane dynamics mental health mental health law mental health training and education metabolism methionine methionine synthase methodology microglia middle aged mitochondria mitochondrial complexes mitochondrial membrane potential mitochondris molecular cloning molecular weight monoclonal antibody monoclonal antibody 76F monolayer culture monozygotic twins morphometrics mouse mouse infection model multicenter study multiple endocrine adenomatosis multiple sclerosis muscle rigidity musculoskeletal disease mutation myalgia myelodysplastic syndrome myeloproliferative neoplasms nanomedicine nanotechnology necrosis neonatal nestin neurodegeneration neuroprotection newborn nicotinamide nitric oxide nitrotyrosine non insulin dependent diabetes mellitus nonhuman nuclear family nutrition obesity oligodendrocyte onset age oral antidiabetic agent oral glucose tolerance test outcome assessment outcomes oxidative stress pancreas pancreas islet pancreas islet antibody pancreas islet beta cell pancreas islet cell pancreas islet cell antibody pancreas islet cell antibody, adolescent pancreas islet cell antibody, adult pancreas islet cell antibody, animal pancreas islet cell function pancreas islet cell protein pancreas islet cell, Animal pancreas islet transplantation pancreatitis parent pathogenesis patient characteristics patient compliance patient satisfaction performance perfusion perinatal period permeability transition pore peroxynitrite person-centered healthcare phenotype phosphatase, adolescent phospholipid placebo, article poly-pharmacy polyendocrinopathy population research practitioner perspectives pre-hospital prediction prediction and forecasting predictors of transport to hospital pregnancy diabetes mellitus preschool child preschool child, Adolescent presenilin-1 prevalence primary care primase priority journal priority journal, Adolescent priority journal, Adult priority journal, Animal priority journal, Antibody Specificity progeny, Animals prognosis proinsulin prospective study prostate cancer protein analysis protein analysis, Animals protein antibody protein antibody, adolescent protein conformation protein degradation, Antigen-Antibody Reactions protein expression protein tyrosine phosphatase protein tyrosine phosphatase, adolescent protein tyrosine phosphatase, adult protein tyrosine phosphatase, article protein tyrosine phosphatase, autoimmunity protein, antigen binding purification qualitatiove interview study quality control quality of care quantification questionnaire development and validation radioassay radioimmunoprecipitation randomized controlled trial rat rat strain rat, Adolescent rat, Amino Acid Sequence rat, Animal rat, Antibody Specificity reactivity recombinant protein recombinant protein, adolescent redox redox homeostasis redox state redox-dependent reference value register relative, Adolescent reliability remission reperfusion request a copy resiniferatoxin resistance resistance training respiratory chain complexes resveratrol review review, Animal review, Autoantibodies risk risk assessment tools risk factor risk reduction sample size schizophrenia school child school child, Adolescent screening test, Adolescent screening, Adolescent secretion (process), Mus, Animals serum, Adolescent service user perspectives sexual development, Adolescent skin skin blood flow skin temperature social inclusion social work degree social work practice socioeconomic status solid cancers staff development staining stiff man syndrome, Adolescent stiff man syndrome, Adult storage streptavidin streptozocin diabetes streptozocin diabetes, Animals streptozocin, animal experiment streptozocin, animal model stretching exercise structured judgement case note review student support sulfur sulfur 35, adolescent superoxide dismutase supravital stain, Animal surface plasmon resonance sweden, Animal t lymphocyte, Adenocarcinoma t lymphocyte, Autoantibodies thematic synthesis time, Adult tissue culture, Adolescent tissue distribution, Animal training transcription factor PDX 1 treatment failure treatment outcome treatment outcome, Adolescent treatment response tricyclic trypsin trypsin, affinity chromatography trypsin, amino acid sequence tumor necrosis factor alpha, adult tutoring twin discordance, Adolescent type 1 diabetes tyrosine phosphatase ubiquinone unclassified drug, adolescent unclassified drug, adult unclassified drug, animal cell unclassified drug, antibody specificity unclassified drug, human vimentin, animal experiment virus vitagenes vitamin E waist circumference
Number of items at this level: 2152.

(E) - capsaicin

Athanasiou, Andriani, Smith, Paul A., Vakilpour, Sara, Kumaran, Nethia M., Turner, Amy E., Bagiokou, Dimitra, Layfield, Robert, Ray, David E., Westwell, Andrew D., Alexander, Stephen P. H., Kendall, David A., Lobo, Dileep N., Watson, Susan A., Lophatanon, Artitaya, Muir, Kenneth A., Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

1-methyl-4-phenylpyridinium

Bates, T. E., Heales, S. J., Davies, S. E., Boakye, P. and Clark, J. B. (1994) Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. Journal of neurochemistry, 63 (2). pp. 640-648. ISSN 0022-3042

13C

Bakken, Inger J., Sonnewald, Ursula, Clark, John B. and Bates, Timothy E. (1997) [U-13C]glutamate metabolism in rat brain mitochondria reveals malic enzyme activity. Neuroreport, 8 (7). pp. 1567-1570. ISSN 0959-4965

1H

Bates, Timothy E., Strangward, Maria, Keelan, Julia, Davey, Gavin P., Munro, Peter M. G. and Clark, John B. (1996) Inhibition of N-acetylaspartate production: implications for 1H MRS studies in vivo. Neuroreport, 7 (8). pp. 1397-1400. ISSN 0959-4965

Brooks, K. J., Clark, J. B. and Bates, T. E. (1996) Assessment of energy metabolism in the developing brain following aglycemic hypoxia by 1H and 31P NMR. Neurochemical Research, 21 (9). pp. 1089-1095. ISSN 0364-3190

31P

Brooks, K. J., Clark, J. B. and Bates, T. E. (1996) Assessment of energy metabolism in the developing brain following aglycemic hypoxia by 1H and 31P NMR. Neurochemical Research, 21 (9). pp. 1089-1095. ISSN 0364-3190

Dagnelie, P. C., Bell, J. D., Williams, S. C., Bates, T. E., Abel, P. D. and Foster, C. S. (1993) Altered phosphorylation status, phospholipid metabolism and gluconeogenesis in the host liver of rats with prostate cancer: a 31P magnetic resonance spectroscopy study. British Journal of Cancer, 67 (6). pp. 1303-1309. ISSN 0007-0920

Dagnelie, Pieter C., Bell, Jimmy D., Williams, Steve C., Bates, Timothy E., Abel, Paul D. and Foster, Christopher S. (1994) Effect of fish oil on cancer cachexia and host liver metabolism in rats with prostate tumors. Lipids, 29 (3). pp. 195-203. ISSN 0024-4201

Murphy, Elizabeth J., Bates, Timothy E., Williams, Stephen R., Watson, Tracey, Brindle, Kevin M., Rajagopalan, Bheeshma and Radda, George K. (1992) Endoplasmic reticulum: the major contributor to the PDE peak in hepatic 31P-NMR spectra at low magnetic field strengths. Biochimica et biophysica acta: biomembranes, 1111 (1). pp. 51-58. ISSN 0005-2736

4 aminobutyric acid

Bonifacio, E. and Christie, M. R. (1996) Tyrosine phosphatase-like proteins as autoantigens in insulin-dependent diabetes mellitus: the targets for 37/40k antibodies. Diabetes, Nutrition and Metabolism - Clinical and Experimental, 9 (4). pp. 183-187. ISSN 0394-3402

AEA

Athanasiou, Andriani, Clarke, Anna B., Turner, Amy E., Kumaran, Nethia M., Vakilpour, Sara, Smith, Paul A., Bagiokou, Dimitra, Bradshaw, Tracey D., Westwell, Andrew D., Fang, Lin, Lobo, Dileep N., Constantinescu, Cris S., Calabrese, Vittorio, Loesch, Andrzej, Alexander, Stephen P. H., Clothier, Richard H., Kendall, David A. and Bates, Timothy E. (2007) Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications, 364 (1). pp. 131-137. ISSN 0006-291x

AFM

Siamantouras, Eleftherios, Hills, Claire E., Liu, Kuo-Kang and Squires, Paul E. (2020) Chapter 14: Examining cell-cell interactions in the kidney using AFM single-cell force spectroscopy. In: Diabetic Nephropathy Methods & Protocols. Methods in Molecular Biology Series, 2067 . Springer Science+Business Media, LLC, part of Springer Nature. ISBN 978-1-4939-9840-1

Siamantouras, Eleftherios, Hills, Claire, Liu, Kuo-Kang and Squires, Paul (2020) Examining Cell-Cell Interactions in the Kidney Using AFM Single-Cell Force Spectroscopy. In: Diabetic Nephropathy. Methods in Molecular Biology, 2067 . Humana Press, Humana, New York, NY, pp. 189-201. ISBN 978-1-4939-9840-1, 978-1-4939-9841-8

AFM-SCFS

Siamantouras, Eleftherios, Price, Gareth, Potter, Joe, Hills, Claire and Squires, Paul (2019) Purinergic receptor (P2X7) activation reduces cell–cell adhesion between tubular epithelial cells of the proximal kidney. Nanomedicine: Nanotechnology, Biology and Medicine, 22 . ISSN 1549-9634

Squires, Paul, Siamantouras, Eleftherios, Potter, Joe, Price, Gareth and Hills, Claire (2019) ATP reduces functional cell-to-cell tethering between renal tubular epithelial cells. In: Physiology 2019 (The Physiological Society), 08/07/19-to-10/07/19, Aberdeen.

AME

Senyuk, Vitalyi, Rinaldi, Ciro Roberto, Li, Donglan, Cattaneo, Francesca, Stojanovic, Aleksandra, Pane, Fabrizio, Du, Xiaoping, Mahmud, Nadim, Dickstein, Jerome and Nucifora, Giuseppina (2009) Consistent up-regulation of Stat3 Independently of Jak2 mutations in a new murine model of essential thrombocythemia. Cancer research, 69 (1). pp. 262-271. ISSN 0008-5472

AMPA

Rosin, Claudia, Bates, Timothy E. and Skaper, Stephen D. (2004) Excitatory amino acid induced oligodendrocyte cell death in vitro: receptor-dependent and -independent mechanisms. Journal of Neurochemistry, 90 (5). pp. 1173-1185. ISSN 0022-3042

ATP

Allen, Kathryn L., Almeida, Angeles, Bates, Timothy E. and Clark, John B. (1995) Changes of respiratory chain activity in mitochondrial and synaptosomal fractions isolated from the gerbil brain after graded ischaemia. Journal of neurochemistry, 64 (5). pp. 2222-2229. ISSN 0022-3042

Bates, T. E., Heales, S. J., Davies, S. E., Boakye, P. and Clark, J. B. (1994) Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. Journal of neurochemistry, 63 (2). pp. 640-648. ISSN 0022-3042

Siamantouras, Eleftherios, Price, Gareth, Potter, Joe, Hills, Claire and Squires, Paul (2019) Purinergic receptor (P2X7) activation reduces cell–cell adhesion between tubular epithelial cells of the proximal kidney. Nanomedicine: Nanotechnology, Biology and Medicine, 22 . ISSN 1549-9634

Squires, Paul, Siamantouras, Eleftherios, Potter, Joe, Price, Gareth and Hills, Claire (2019) ATP reduces functional cell-to-cell tethering between renal tubular epithelial cells. In: Physiology 2019 (The Physiological Society), 08/07/19-to-10/07/19, Aberdeen.

AZT-TP; NRTI; drug delivery; metal organic framework; nanoparticle

Agostoni, Valentina, Chalati, Tamim, Horcajada, Patricia, Willaime, Hervé, Anand, Resmi, Semiramoth, Nicolas, Baati, Tarek, Hall, Shaun, Maurin, Guillaume, Chacun, Hélène, Bouchemal, Kawthar, Martineau, Charlotte, Taulelle, Francis, Couvreur, Patrick, Rogez-Kreuz, Christine, Clayette, Pascal, Monti, Sandra, Serre, Christian and Gref, Ruxandra (2013) Towards an Improved anti-HIV Activity of NRTI via Metal-Organic Frameworks Nanoparticles. Advanced Healthcare Materials, 2 (12). pp. 1630-1637. ISSN 2012-0454

Accelerometers

Ruder, M., Jamison, S., Tenforde, A., Mulloy, F. and Davis, I. (2019) Relationship of Footstrike Pattern and Landing Impacts during a Marathon. Medicine and Science in Sports and Exercise, 51 (10). pp. 2073-2079. ISSN 0195-9131

Acute Inflammatory Demyelinating Polyneuropathy

Curtis, Ffion, Laparidou, Despina, Akanuwe, N.A Joseph, Ellis-Vowles, Victoria, Jackson, Jennifer, Senevirathna, Mahendra, Menezes, Igor, Hodgson, Timothy and Siriwardena, A. Niroshan (2019) Patient experiences and perceptions of Guillain-Barré Syndrome and associated inflammatory neuropathies following discharge from hospital. PROSPERO: International prospective register of systematic reviews .

Adherens Junction

Siamantouras, Eleftherios, Price, Gareth, Potter, Joe, Hills, Claire and Squires, Paul (2019) Purinergic receptor (P2X7) activation reduces cell–cell adhesion between tubular epithelial cells of the proximal kidney. Nanomedicine: Nanotechnology, Biology and Medicine, 22 . ISSN 1549-9634

Adolescent

Wagner, R., McNally, J. M., Bonifacio, E., Genovese, S., Foulis, A., McGill, M., Christie, M. R., Betterle, C., Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

Adolescents

French, Rebecca, Stephenson, Judith, Kane, Ros, Kingori, Patricia, Hadley, Alison and Wellings, Kaye (2004) How good is the provision of sexual health services for young people across England? In: 8th Congress of the European Society of Contraception, Edinburgh, June 2004, 23 - 26 June 2004, Edinburgh.

Adult

Christie, M. R., Genovese, S., Cassidy, D., Bosi, E., Brown, T. J., Lai, M., Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

Christie, M. R., Vohra, G., Champagne, P., Daneman, D. and Delovitch, T. L. (1990) Distinct antibody specificities to a 64-kD islet cell antigen in Type 1 diabetes as revealed by trypsin treatment. Journal of Experimental Medicine, 172 (3). pp. 789-794. ISSN 0022-1007

Huang, Guo Cai, Zhao, Min, Jones, Peter, Persaud, Shanta, Ramracheya, Reshma, Lobner, Kristian, Christie, Michael R., Banga, J. Paul, Peakman, Mark, Sirinivsan, Parthi, Rela, Mohammed, Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Morgenthaler, N. G., Seissler, J., Achenbach, P., Glawe, D., Payton, M., Meinck, H.-M., Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Wagner, R., Genovese, S., Bosi, E., Becker, F., Bingley, P. J., Bonifacio, E., Miles, K. A., Christie, Michael, Bottazzo, G. F. and Gale, E. A. M. (1994) Slow metabolic deterioration towards diabetes in islet cell antibody positive patients with autoimmune polyendocrine disease. Diabetologia, 37 (4). pp. 365-371. ISSN 0012-186X

Zhao, M., Amiel, S. A., Christie, Michael R., Rela, M., Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Age

Tew, G., Klonizakis, Markos, Moss, J., Ruddock, A. D., Saxton, J. M. and Hodges, G. J. (2011) Reproducibility of cutaneous thermal hyperaemia assessed by laser Doppler flowmetry in young and older adults. Microvascular Research, 81 (2). pp. 177-182. ISSN 0026-2862

Age of Onset

Damanhouri, L. H., Dromey, J. A., Christie, Michael R., Nasrat, H. A., Ardawi, M. S. M., Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Desai, M.a, Cull, C.A.b, Horton, V.A.a, Christie, M.R.c, Bonifacio, E.d, Lampasona, V.d, Bingley, P.J.e, Levy, J.C.a, Mackay, I.R.f, Zimmet, P.g, Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Gillespie, Kathleen M., Bain, Steven C., Barnett, Anthony H., Bingley, Polly J., Christie, Michael R., Gill, Geoffrey V. and Gale, Edwin A. M. (2004) The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. The Lancet, 364 (9446). pp. 1699-1700. ISSN 0140-6736

Gorus, F. K., Goubert, P., Semakula, C., Vandewalle, C. L., De Schepper, J., Scheen, A., Christie, Michael R. and Pipeleers, D. G. (1997) IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia, 40 (1). pp. 95-99. ISSN 0012-186X

Aged

Hawa, M., Rowe, R., Lan, M. S., Notkins, A. L., Pozzilli, P., Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Wagner, R., Genovese, S., Bosi, E., Becker, F., Bingley, P. J., Bonifacio, E., Miles, K. A., Christie, Michael, Bottazzo, G. F. and Gale, E. A. M. (1994) Slow metabolic deterioration towards diabetes in islet cell antibody positive patients with autoimmune polyendocrine disease. Diabetologia, 37 (4). pp. 365-371. ISSN 0012-186X

Aged, 80 and over

Morgenthaler, N. G., Seissler, J., Achenbach, P., Glawe, D., Payton, M., Meinck, H.-M., Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Wagner, R., McNally, J. M., Bonifacio, E., Genovese, S., Foulis, A., McGill, M., Christie, M. R., Betterle, C., Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

Ageing

Tew, G., Klonizakis, Markos and Saxton, G. (2010) Effects of ageing and fitness on skin-microvessel vasodilator function in humans. European Journal of Applied Physiology, 109 (2). pp. 173-181. ISSN 1439-6319

Aging

Roll, U., Christie, M. R., Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

Alleles

Gylling, Mikhail, Tuomi, Tiinamaija, Bjorses, Petra, Kontiainen, Sirkka, Partanen, Jukka, Christie, Michael R., Knip, Mikael, Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

Allopurinol

Huang, Guo Cai, Zhao, Min, Jones, Peter, Persaud, Shanta, Ramracheya, Reshma, Lobner, Kristian, Christie, Michael R., Banga, J. Paul, Peakman, Mark, Sirinivsan, Parthi, Rela, Mohammed, Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Alzheimer's

Mancuso, Cesare, Bates, Timothy E., Butterfield, D. Allan, Calafato, Stella, Cornelius, Carolin, De Lorenzo, Antonino, Dinkova Kostova, Albena T. and Calabrese, Vittorio (2007) Natural antioxidants in Alzheimer's disease. Expert Opinion on Investigational Drugs, 16 (12). pp. 1921-1931. ISSN 1354-3784

Pardon, Marie-Christine, Sarmad, Sarir, Rattray, Ivan, Bates, Timothy E., Scullion, Gillian A., Marsden, Charles A., Barrett, David A., Lowe, James and Kendall, David A. (2009) Repeated novel cage exposure-induced improvement of early Alzheimer's-like cognitive and amyloid changes in TASTPM mice is unrelated to changes in brain endocannabinoids levels. Neurobiology of Aging, 30 (7). pp. 1099-1113. ISSN 0197-4580

Animal

Christie, M. R., Vohra, G., Champagne, P., Daneman, D. and Delovitch, T. L. (1990) Distinct antibody specificities to a 64-kD islet cell antigen in Type 1 diabetes as revealed by trypsin treatment. Journal of Experimental Medicine, 172 (3). pp. 789-794. ISSN 0022-1007

Christie, Michael, Brown, T. J. and Cassidy, D. (1992) Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme. Diabetologia, 35 (4). pp. 380-384. ISSN 0012-186X

Roll, U., Christie, M. R., Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

Animals

Huang, Guo Cai, Zhao, Min, Jones, Peter, Persaud, Shanta, Ramracheya, Reshma, Lobner, Kristian, Christie, Michael R., Banga, J. Paul, Peakman, Mark, Sirinivsan, Parthi, Rela, Mohammed, Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Piquer, Sandra, Valera, Lionel, Lampasona, Vito, Jardin-Watelet, Benedicte, Roche, Stephanie, Granier, Claude, Roquet, Francoise, Christie, Michael R., Giordano, Tiziana, Malosio, Maria-Luisa, Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

Zhao, M., Amiel, S. A., Christie, Michael R., Rela, M., Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Animals, Newborn

Christie, M. R., Pipeleers, D. G., Lernmark, A. and Baekkeskov, S. (1990) Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes. Journal of Biological Chemistry, 265 (1). pp. 376-381. ISSN 0021-9258

Christie, M. R., Vohra, G., Champagne, P., Daneman, D. and Delovitch, T. L. (1990) Distinct antibody specificities to a 64-kD islet cell antigen in Type 1 diabetes as revealed by trypsin treatment. Journal of Experimental Medicine, 172 (3). pp. 789-794. ISSN 0022-1007

Antibodies

Christie, M. R., Daneman, D., Champagne, P. and Delovitch, T. L. (1990) Persistence of serum antibodies to 64,000-Mr islet cell protein after onset of type I diabetes. Diabetes, 39 (6). pp. 653-656. ISSN 0012-1797

Hawkes, C. J., Wasmeier, C., Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Roll, U., Christie, M. R., Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

Antibodies, Monoclonal

Piquer, Sandra, Valera, Lionel, Lampasona, Vito, Jardin-Watelet, Benedicte, Roche, Stephanie, Granier, Claude, Roquet, Francoise, Christie, Michael R., Giordano, Tiziana, Malosio, Maria-Luisa, Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

Wagner, R., McNally, J. M., Bonifacio, E., Genovese, S., Foulis, A., McGill, M., Christie, M. R., Betterle, C., Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

Antibody Formation

Roll, U., Christie, M. R., Fuchtenbusch, M., Payton, M. A., Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Antibody Specificity

Baekkeskov, S., Warnock, G., Christie, M., Rajotte, R.V., Larsen, P.M. and Fey, S. (1989) Revelation of specificity of 64K autoantibodies in IDDM serums by high-resolution 2-D gel electrophoresis. Unambiguous identification of 64K target antigen. Diabetes, 38 (9). pp. 1133-1141. ISSN 0012-1797

Christie, M. R., Vohra, G., Champagne, P., Daneman, D. and Delovitch, T. L. (1990) Distinct antibody specificities to a 64-kD islet cell antigen in Type 1 diabetes as revealed by trypsin treatment. Journal of Experimental Medicine, 172 (3). pp. 789-794. ISSN 0022-1007

Morgenthaler, N. G., Löbner, K., Morgenthaler, U. Y., Christie, M. R., Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Morgenthaler, N. G., Seissler, J., Achenbach, P., Glawe, D., Payton, M., Meinck, H.-M., Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Piquer, Sandra, Valera, Lionel, Lampasona, Vito, Jardin-Watelet, Benedicte, Roche, Stephanie, Granier, Claude, Roquet, Francoise, Christie, Michael R., Giordano, Tiziana, Malosio, Maria-Luisa, Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

Antigen-Antibody Reactions

Hawkes, C. J., Wasmeier, C., Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Payton, M. A., Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Antigens

Christie, M. R., Tun, R. Y. M., Lo, S. S. S., Cassidy, D., Brown, T. J., Hollands, J., Shattock, M., Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Payton, M. A., Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Antigens, Surface

Christie, M. R., Vohra, G., Champagne, P., Daneman, D. and Delovitch, T. L. (1990) Distinct antibody specificities to a 64-kD islet cell antigen in Type 1 diabetes as revealed by trypsin treatment. Journal of Experimental Medicine, 172 (3). pp. 789-794. ISSN 0022-1007

Antioxidant

Calabrese, V., Bates, T. E. and Stella, A. M. (2000) NO synthase and NO-dependent signal pathways in brain aging and neurodegenerative disorders: the role of oxidant/antioxidant balance. Neurochemical Research, 25 (9-10). pp. 1315-41. ISSN 0364-3190

Calabrese, V., Scapagnini, G., Catalano, C., Bates, T. E., Dinotta, F., Micali, G. and Giuffrida Stella, A. M. (2001) Induction of heat shock protein synthesis in human skin fibroblasts in response to oxidative stress: regulation by a natural antioxidant from rosemary extract. International Journal of Tissue Reactions, 23 (2). pp. 51-8. ISSN 0250-0868

Antioxidants

Mancuso, Cesare, Bates, Timothy E., Butterfield, D. Allan, Calafato, Stella, Cornelius, Carolin, De Lorenzo, Antonino, Dinkova Kostova, Albena T. and Calabrese, Vittorio (2007) Natural antioxidants in Alzheimer's disease. Expert Opinion on Investigational Drugs, 16 (12). pp. 1921-1931. ISSN 1354-3784

Anxiety; Chronopharmacology; Depression; Epilepsy; Melatonin

Tchekalarova, Jana, Moyanova, Slavianka, Fusco, Antonio De and Ngomba, Richard Teke (2015) The role of the melatoninergic system in epilepsy and comorbid psychiatric disorders. Brain Research Bulletin, 119 (A). pp. 80-92. ISSN 0361-9230

Apoptosis

Long, Lu, Ormiston, Mark L., Yang, Xudong, Southwood, Mark, Gräf, Stefan, Machado, Rajiv D., Mueller, Matthias, Kinzel, Bernd, Yung, Lai Ming, Wilkinson, Janine M., Moore, Stephen D., Drake, Kylie M., Aldred, Micheala A., Yu, Paul B., Upton, Paul D. and Morrell, Nicholas W. (2015) Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension. Nature Medicine, 21 (7). pp. 777-785. ISSN 1078-8956

Applied Knowledge Test

Asghar, Zahid and Siriwardena, Niro (2018) Performance of candidates with dyslexia in the Applied Knowledge Test for membership of the Royal College of General Practitioners. In: SAPC ASM 2017 - Warwick 46th annual scientific meeting, 12 - 14 July 2017, Warwick.

Arabs

Damanhouri, L. H., Dromey, J. A., Christie, Michael R., Nasrat, H. A., Ardawi, M. S. M., Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Article

Hasnain, Sumaira Z., Borg, Danielle J., Harcourt, Brooke E., Tong, Hui, Sheng, Yonhua H., Ng, Choa ping, Das, Indrajit, Wang, Ran, Chen, Alice C.-H., Loudovaris, Thomas, Kay, Thomas W., Thomas, Helen E., Whitehead, Jonathan P., Forbes, Josephine M., Prins, Johannes B. and McGuckin, Michael A. (2014) Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress. Nature Medicine, 20 (12). pp. 1417-1426. ISSN 1078-8956

Winzer, Brooke M., Paratz, Jennifer D., Whitehead, Jonathan P., Whiteman, David C. and Reeves, Marina M. (2015) The feasibility of an exercise intervention in males at risk of oesophageal adenocarcinoma: a randomized controlled trial. PLoS ONE, 10 (2). ISSN 1932-6203

Autoantibodies

Baekkeskov, S., Warnock, G., Christie, M., Rajotte, R.V., Larsen, P.M. and Fey, S. (1989) Revelation of specificity of 64K autoantibodies in IDDM serums by high-resolution 2-D gel electrophoresis. Unambiguous identification of 64K target antigen. Diabetes, 38 (9). pp. 1133-1141. ISSN 0012-1797

Bearzatto, Massimo, Naserke, Heike, Piquer, Sandra, Koczwara, Kerstin, Lampasona, Vito, Williams, Alistair, Christie, Michael R., Bingley, Polly J., Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Bingley, P. J., Christie, M. R., Bonifacio, E., Bonfanti, R., Shattock, M., Fonte, M.-T., Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Bottazzo, G. F., Genovese, S., Bosi, E., Dean, B. M., Christie, M. R. and Bonifacio, E. (1991) Novel considerations on the antibody/autoantigen system in type I (insulin-dependent) diabetes mellitus. Annals of Medicine, 23 (4). pp. 453-461. ISSN 0785-3890

Catani, Mara, Walther, Denise, Christie, Michael, McLaughlin, Kerry, Bonifacio, Ezio and Eugster, Anne (2015) Isolation of human monoclonal autoantibodies derived from pancreatic lymph node and peripheral blood B cells of islet autoantibody-positive patients. Diabetologia . ISSN 0012-186X

Christie, M. R. (1993) Characterization of distinct islet protein auto antigens associated with type 1 diabetes. Autoimmunity, 15 (s1). pp. 1-3. ISSN 0891-6934

Christie, M. R., Genovese, S., Cassidy, D., Bosi, E., Brown, T. J., Lai, M., Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

Christie, M. R., Tun, R. Y. M., Lo, S. S. S., Cassidy, D., Brown, T. J., Hollands, J., Shattock, M., Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Christie, M. R., Vohra, G., Champagne, P., Daneman, D. and Delovitch, T. L. (1990) Distinct antibody specificities to a 64-kD islet cell antigen in Type 1 diabetes as revealed by trypsin treatment. Journal of Experimental Medicine, 172 (3). pp. 789-794. ISSN 0022-1007

Christie, Michael, Brown, T. J. and Cassidy, D. (1992) Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme. Diabetologia, 35 (4). pp. 380-384. ISSN 0012-186X

Christie, Michael, Landin-Olsson, M., Sundkvist, G., Dahlquist, G., Lernmark, A. and Baekkeskov, S. (1988) Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes. Diabetologia, 31 (8). pp. 597-602. ISSN 0012-186X

Christie, Michael R., Roll, Ursula, Payton, Mark A., Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Christie, M. R., Hollands, J. A., Brown, T. J., Michelsen, B. K. and Delovitch, T. L. (1993) Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. Journal of Clinical Investigation, 92 (1). pp. 240-248. ISSN 0021-9738

Christie, Michael R., Molvig, Jens, Hawkes, Charlotte J., Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

Damanhouri, L. H., Dromey, J. A., Christie, Michael R., Nasrat, H. A., Ardawi, M. S. M., Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Desai, M.a, Cull, C.A.b, Horton, V.A.a, Christie, M.R.c, Bonifacio, E.d, Lampasona, V.d, Bingley, P.J.e, Levy, J.C.a, Mackay, I.R.f, Zimmet, P.g, Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Gorus, F. K., Goubert, P., Semakula, C., Vandewalle, C. L., De Schepper, J., Scheen, A., Christie, Michael R. and Pipeleers, D. G. (1997) IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia, 40 (1). pp. 95-99. ISSN 0012-186X

Gylling, Mikhail, Tuomi, Tiinamaija, Bjorses, Petra, Kontiainen, Sirkka, Partanen, Jukka, Christie, Michael R., Knip, Mikael, Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

Hatfield, E. C. I., Hawkes, C. J., Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Hawa, M., Rowe, R., Lan, M. S., Notkins, A. L., Pozzilli, P., Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Hawkes, C. J., Wasmeier, C., Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Lampeter, E. F., Kolb, H., Seifert, I., Lohmann, D., Heise, J. W., Bertrams, J., Christie, Michael and Kolb-Bachofen, V. (1994) Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity. Diabetologia, 37 (5). pp. 471-475. ISSN 0012-186X

McLaughlin, Kerry A, Tombs, Melissa and Christie, Michael (2020) Autoimmunity to tetraspanin-7 in type 1 diabetes. Medical Microbiology and immunology . ISSN 0300-8584

Morgenthaler, N. G., Löbner, K., Morgenthaler, U. Y., Christie, M. R., Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Morgenthaler, N. G., Seissler, J., Achenbach, P., Glawe, D., Payton, M., Meinck, H.-M., Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Piquer, Sandra, Valera, Lionel, Lampasona, Vito, Jardin-Watelet, Benedicte, Roche, Stephanie, Granier, Claude, Roquet, Francoise, Christie, Michael R., Giordano, Tiziana, Malosio, Maria-Luisa, Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

Richardson, Carolyn, McLaughlin, Kerry, Morgan, Diana, Feltbower, Richard and Christie, Michael (2016) Influence of HLA-DR and -DQ alleles on autoantibody recognition of distinct epitopes within the juxtamembrane domain of the IA-2 autoantigen in type 1 diabetes. Diabetologia, 59 (2). pp. 334-340. ISSN 0012-186X

Roll, U., Christie, M. R., Fuchtenbusch, M., Payton, M. A., Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Roll, U., Christie, M. R., Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

Seissler, J., Morgenthaler, N. G., Achenbach, P., Lampeter, E .F., Glawe, D., Payton, M., Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

Tremble, Jennifer, Morgenthaler, Nils G., Vlug, Arjen, Powers, Alvin C., Christie, Michael R., Scherbaum, Werner A. and Banga, J. Paul (1997) Human B cells secreting immunoglobulin G to glutamic acid decarboxylase- 65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes. Journal of Clinical Endocrinology and Metabolism, 82 (8). pp. 2664-2670. ISSN 0021-972X

Wagner, R., Genovese, S., Bosi, E., Becker, F., Bingley, P. J., Bonifacio, E., Miles, K. A., Christie, Michael, Bottazzo, G. F. and Gale, E. A. M. (1994) Slow metabolic deterioration towards diabetes in islet cell antibody positive patients with autoimmune polyendocrine disease. Diabetologia, 37 (4). pp. 365-371. ISSN 0012-186X

Wagner, R., McNally, J. M., Bonifacio, E., Genovese, S., Foulis, A., McGill, M., Christie, M. R., Betterle, C., Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

Winnock, Frederic, Christie, Michael R., Batstra, Manou R., Aanstoot, Henk-Jan, Weets, Ilse, Decochez, Katelijn, Jopart, Philippe, Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

Autoantigens

Bearzatto, Massimo, Naserke, Heike, Piquer, Sandra, Koczwara, Kerstin, Lampasona, Vito, Williams, Alistair, Christie, Michael R., Bingley, Polly J., Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Bonifacio, E. and Christie, M. R. (1997) Islet cell antigens in the prediction and prevention of insulin-dependent diabetes mellitus. Annals of Medicine, 29 (5). pp. 405-412. ISSN 0785-3890

Bottazzo, G. F., Genovese, S., Bosi, E., Dean, B. M., Christie, M. R. and Bonifacio, E. (1991) Novel considerations on the antibody/autoantigen system in type I (insulin-dependent) diabetes mellitus. Annals of Medicine, 23 (4). pp. 453-461. ISSN 0785-3890

Christie, M. R. (1993) Characterization of distinct islet protein auto antigens associated with type 1 diabetes. Autoimmunity, 15 (s1). pp. 1-3. ISSN 0891-6934

Christie, M. R. (1996) Islet cell autoantigens in type 1 diabetes. European Journal of Clinical Investigation, 26 (10). pp. 827-838. ISSN 0014-2972

Christie, M. R., Genovese, S., Cassidy, D., Bosi, E., Brown, T. J., Lai, M., Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

Christie, M. R., Pipeleers, D. G., Lernmark, A. and Baekkeskov, S. (1990) Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes. Journal of Biological Chemistry, 265 (1). pp. 376-381. ISSN 0021-9258

Christie, M. R., Tun, R. Y. M., Lo, S. S. S., Cassidy, D., Brown, T. J., Hollands, J., Shattock, M., Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Christie, Michael, Landin-Olsson, M., Sundkvist, G., Dahlquist, G., Lernmark, A. and Baekkeskov, S. (1988) Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes. Diabetologia, 31 (8). pp. 597-602. ISSN 0012-186X

Christie, Michael R., Roll, Ursula, Payton, Mark A., Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Christie, M. R., Hollands, J. A., Brown, T. J., Michelsen, B. K. and Delovitch, T. L. (1993) Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. Journal of Clinical Investigation, 92 (1). pp. 240-248. ISSN 0021-9738

Hatfield, E. C. I., Hawkes, C. J., Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Hawa, M., Rowe, R., Lan, M. S., Notkins, A. L., Pozzilli, P., Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Hawkes, C. J., Wasmeier, C., Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Hawkes, C. J., Schloot, N. C., Marks, J., Willemen, S. J. M., Drijfhout, J. W., Mayer, E. K., Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

McLaughlin, Kerry A., Richardson, Carolyn C., Ravishankar, Aarthi, Brigatti, Cristina, Liberati, Daniela, Lampasona, Vito, Piemonti, Lorenzo, Morgan, Diana, Feltbower, Richard G. and Christie, Michael R. (2016) Identification of tetraspanin-7 as a target of autoantibodies in type 1 diabetes. Diabetes, 65 (6). pp. 1690-1698. ISSN 0012-1797

Morgenthaler, N. G., Löbner, K., Morgenthaler, U. Y., Christie, M. R., Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Morgenthaler, N. G., Seissler, J., Achenbach, P., Glawe, D., Payton, M., Meinck, H.-M., Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Piquer, Sandra, Valera, Lionel, Lampasona, Vito, Jardin-Watelet, Benedicte, Roche, Stephanie, Granier, Claude, Roquet, Francoise, Christie, Michael R., Giordano, Tiziana, Malosio, Maria-Luisa, Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

Autoimmune Diseases

Bottazzo, G. F., Genovese, S., Bosi, E., Dean, B. M., Christie, M. R. and Bonifacio, E. (1991) Novel considerations on the antibody/autoantigen system in type I (insulin-dependent) diabetes mellitus. Annals of Medicine, 23 (4). pp. 453-461. ISSN 0785-3890

Christie, M. R. (1993) Characterization of distinct islet protein auto antigens associated with type 1 diabetes. Autoimmunity, 15 (s1). pp. 1-3. ISSN 0891-6934

Damanhouri, L. H., Dromey, J. A., Christie, Michael R., Nasrat, H. A., Ardawi, M. S. M., Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Morgenthaler, N. G., Seissler, J., Achenbach, P., Glawe, D., Payton, M., Meinck, H.-M., Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Autoimmunity

McLaughlin, Kerry A., Richardson, Carolyn C., Williams, Stefan, Bonifacio, Ezio, Morgan, Diana, Feltbower, Richard G., Powell, Michael, Rees Smith, Bernard, Furmaniak, Jadwiga and Christie, Michael R. (2015) Relationships between major epitopes of the IA-2 autoantigen in Type 1 diabetes: implications for determinant spreading. Clinical Immunology, 160 (2). pp. 226-236. ISSN 1521-6616

McLaughlin, Kerry A, Tombs, Melissa and Christie, Michael (2020) Autoimmunity to tetraspanin-7 in type 1 diabetes. Medical Microbiology and immunology . ISSN 0300-8584

McLaughlin, Kerry A., Richardson, Carolyn C., Ravishankar, Aarthi, Brigatti, Cristina, Liberati, Daniela, Lampasona, Vito, Piemonti, Lorenzo, Morgan, Diana, Feltbower, Richard G. and Christie, Michael R. (2016) Identification of tetraspanin-7 as a target of autoantibodies in type 1 diabetes. Diabetes, 65 (6). pp. 1690-1698. ISSN 0012-1797

Autoradiography

Christie, M. R., Daneman, D., Champagne, P. and Delovitch, T. L. (1990) Persistence of serum antibodies to 64,000-Mr islet cell protein after onset of type I diabetes. Diabetes, 39 (6). pp. 653-656. ISSN 0012-1797

Azo Compounds

Hansen, W.A., Christie, M.R., Kahn, R., Norgaard, A., Abel, I., Petersen, A.M., Jorgensen, D.W., Baekkeskov, S., Nielsen, J.H., Lernmark, A., Egeberg, J., Richter-Olesen, H., Grainger, T., Kristensen, J.K., Brynitz, S. and Bilde, T. (1989) Supravital dithizone staining in the isolation of human and rat pancreatic islets. Diabetes Research, 10 (2). pp. 53-57. ISSN 0265-5985

B lymphocyte

Bearzatto, Massimo, Naserke, Heike, Piquer, Sandra, Koczwara, Kerstin, Lampasona, Vito, Williams, Alistair, Christie, Michael R., Bingley, Polly J., Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

BAY 57-1293

Biswas, Subhajit, Nunez Miguel, Ricardo, Sukla, Soumi and Field, Hugh J. (2009) A mutation in helicase motif IV of herpes simplex virus type 1 UL5 that results in reduced growth in vitro and lower virulence in a murine infection model is related to the predicted helicase structure. Journal of General Virology, 90 (8). pp. 1937-1942. ISSN 0022-1317

BMP9

Long, Lu, Ormiston, Mark L., Yang, Xudong, Southwood, Mark, Gräf, Stefan, Machado, Rajiv D., Mueller, Matthias, Kinzel, Bernd, Yung, Lai Ming, Wilkinson, Janine M., Moore, Stephen D., Drake, Kylie M., Aldred, Micheala A., Yu, Paul B., Upton, Paul D. and Morrell, Nicholas W. (2015) Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension. Nature Medicine, 21 (7). pp. 777-785. ISSN 1078-8956

BMPRII

Long, Lu, Ormiston, Mark L., Yang, Xudong, Southwood, Mark, Gräf, Stefan, Machado, Rajiv D., Mueller, Matthias, Kinzel, Bernd, Yung, Lai Ming, Wilkinson, Janine M., Moore, Stephen D., Drake, Kylie M., Aldred, Micheala A., Yu, Paul B., Upton, Paul D. and Morrell, Nicholas W. (2015) Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension. Nature Medicine, 21 (7). pp. 777-785. ISSN 1078-8956

BSO

Heales, S. J., Davies, S. E., Bates, T. E. and Clark, J. B. (1995) Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration. Neurochemical research, 20 (1). pp. 31-38. ISSN 0364-3190

BV2

Moss, David W. and Bates, Timothy E. (2001) Activation of murine microglial cell lines by lipopolysaccharide and interferon-gamma causes NO-mediated decreases in mitochondrial and cellular function. The European Journal of Neuroscience, 13 (3). pp. 529-38. ISSN 0953-816X

Bandages

Eves, Paula, Bullet, Nial A., Haddow, David, Beck, Alison J., Layton, Christopher, Way, Louise, Shard, Alex G., Gawkrodger, David J. and MacNeil, Sheila (2008) Simplifying the delivery of melanocytes and keratinocytes for the treatment of vitiligo using a chemically defined carrier dressing. Journal of Investigative Dermatology, 128 (6). pp. 1554-1564. ISSN 0022-202X

Barrett esophagus

Winzer, Brooke M., Paratz, Jennifer D., Whitehead, Jonathan P., Whiteman, David C. and Reeves, Marina M. (2015) The feasibility of an exercise intervention in males at risk of oesophageal adenocarcinoma: a randomized controlled trial. PLoS ONE, 10 (2). ISSN 1932-6203

Base Sequence

Payton, M. A., Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Belgium

Gorus, F. K., Goubert, P., Semakula, C., Vandewalle, C. L., De Schepper, J., Scheen, A., Christie, Michael R. and Pipeleers, D. G. (1997) IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia, 40 (1). pp. 95-99. ISSN 0012-186X

Winnock, Frederic, Christie, Michael R., Batstra, Manou R., Aanstoot, Henk-Jan, Weets, Ilse, Decochez, Katelijn, Jopart, Philippe, Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

Binding Sites, Antibody

Bearzatto, Massimo, Naserke, Heike, Piquer, Sandra, Koczwara, Kerstin, Lampasona, Vito, Williams, Alistair, Christie, Michael R., Bingley, Polly J., Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Binding, Competitive

Bearzatto, Massimo, Naserke, Heike, Piquer, Sandra, Koczwara, Kerstin, Lampasona, Vito, Williams, Alistair, Christie, Michael R., Bingley, Polly J., Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Christie, M. R., Hollands, J. A., Brown, T. J., Michelsen, B. K. and Delovitch, T. L. (1993) Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. Journal of Clinical Investigation, 92 (1). pp. 240-248. ISSN 0021-9738

Hatfield, E. C. I., Hawkes, C. J., Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Biological Markers

Bonifacio, E. and Christie, M. R. (1997) Islet cell antigens in the prediction and prevention of insulin-dependent diabetes mellitus. Annals of Medicine, 29 (5). pp. 405-412. ISSN 0785-3890

Christie, M. R. (1993) Characterization of distinct islet protein auto antigens associated with type 1 diabetes. Autoimmunity, 15 (s1). pp. 1-3. ISSN 0891-6934

Christie, M. R., Genovese, S., Cassidy, D., Bosi, E., Brown, T. J., Lai, M., Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

Christie, M. R., Tun, R. Y. M., Lo, S. S. S., Cassidy, D., Brown, T. J., Hollands, J., Shattock, M., Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Damanhouri, L. H., Dromey, J. A., Christie, Michael R., Nasrat, H. A., Ardawi, M. S. M., Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Gorus, F. K., Goubert, P., Semakula, C., Vandewalle, C. L., De Schepper, J., Scheen, A., Christie, Michael R. and Pipeleers, D. G. (1997) IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia, 40 (1). pp. 95-99. ISSN 0012-186X

Hawa, M., Rowe, R., Lan, M. S., Notkins, A. L., Pozzilli, P., Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Lampeter, E. F., Kolb, H., Seifert, I., Lohmann, D., Heise, J. W., Bertrams, J., Christie, Michael and Kolb-Bachofen, V. (1994) Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity. Diabetologia, 37 (5). pp. 471-475. ISSN 0012-186X

Seissler, J., Morgenthaler, N. G., Achenbach, P., Lampeter, E .F., Glawe, D., Payton, M., Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

Zhao, M., Amiel, S. A., Christie, Michael R., Rela, M., Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Biomechanics

Ruder, M., Jamison, S., Tenforde, A., Mulloy, F. and Davis, I. (2019) Relationship of Footstrike Pattern and Landing Impacts during a Marathon. Medicine and Science in Sports and Exercise, 51 (10). pp. 2073-2079. ISSN 0195-9131

Blood Glucose

Hasnain, Sumaira Z., Borg, Danielle J., Harcourt, Brooke E., Tong, Hui, Sheng, Yonhua H., Ng, Choa ping, Das, Indrajit, Wang, Ran, Chen, Alice C.-H., Loudovaris, Thomas, Kay, Thomas W., Thomas, Helen E., Whitehead, Jonathan P., Forbes, Josephine M., Prins, Johannes B. and McGuckin, Michael A. (2014) Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress. Nature Medicine, 20 (12). pp. 1417-1426. ISSN 1078-8956

Huang, Guo Cai, Zhao, Min, Jones, Peter, Persaud, Shanta, Ramracheya, Reshma, Lobner, Kristian, Christie, Michael R., Banga, J. Paul, Peakman, Mark, Sirinivsan, Parthi, Rela, Mohammed, Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Wagner, R., Genovese, S., Bosi, E., Becker, F., Bingley, P. J., Bonifacio, E., Miles, K. A., Christie, Michael, Bottazzo, G. F. and Gale, E. A. M. (1994) Slow metabolic deterioration towards diabetes in islet cell antibody positive patients with autoimmune polyendocrine disease. Diabetologia, 37 (4). pp. 365-371. ISSN 0012-186X

Body Mass Index

Desai, M.a, Cull, C.A.b, Horton, V.A.a, Christie, M.R.c, Bonifacio, E.d, Lampasona, V.d, Bingley, P.J.e, Levy, J.C.a, Mackay, I.R.f, Zimmet, P.g, Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Brain

Allen, Kathryn L., Almeida, Angeles, Bates, Timothy E. and Clark, John B. (1995) Changes of respiratory chain activity in mitochondrial and synaptosomal fractions isolated from the gerbil brain after graded ischaemia. Journal of neurochemistry, 64 (5). pp. 2222-2229. ISSN 0022-3042

Almeida, A., Brooks, K. J., Sammut, I., Keelan, J., Davey, G. P., Clark, J. B. and Bates, T. E. (1995) Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain. Developmental neuroscience, 17 (4). pp. 212-218. ISSN 0378-5866

Bakken, Inger J., Sonnewald, Ursula, Clark, John B. and Bates, Timothy E. (1997) [U-13C]glutamate metabolism in rat brain mitochondria reveals malic enzyme activity. Neuroreport, 8 (7). pp. 1567-1570. ISSN 0959-4965

Bates, T. E, Loesch, A., Burnstock, G. and Clark, J. B. (1995) Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver. Biochemical and biophysical research communications, 213 (3). pp. 896-900. ISSN 0006-291X

Bates, T. E., Heales, S. J., Davies, S. E., Boakye, P. and Clark, J. B. (1994) Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. Journal of neurochemistry, 63 (2). pp. 640-648. ISSN 0022-3042

Bates, Timothy E., Strangward, Maria, Keelan, Julia, Davey, Gavin P., Munro, Peter M. G. and Clark, John B. (1996) Inhibition of N-acetylaspartate production: implications for 1H MRS studies in vivo. Neuroreport, 7 (8). pp. 1397-1400. ISSN 0959-4965

Christie, M. R., Genovese, S., Cassidy, D., Bosi, E., Brown, T. J., Lai, M., Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

Christie, M. R., Hollands, J. A., Brown, T. J., Michelsen, B. K. and Delovitch, T. L. (1993) Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. Journal of Clinical Investigation, 92 (1). pp. 240-248. ISSN 0021-9738

Heales, S. J., Davies, S. E., Bates, T. E. and Clark, J. B. (1995) Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration. Neurochemical research, 20 (1). pp. 31-38. ISSN 0364-3190

Keelan, Julie, Bates, Timothy E. and Clark, John B. (1996) Intrasynaptosomal free calcium concentration during rat brain development: effects of hypoxia, aglycaemia, and ischaemia. Journal of neurochemistry, 66 (6). pp. 2460-7. ISSN 0022-3042

Payton, M. A., Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Roll, U., Christie, M. R., Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

Brain Chemistry

Christie, M. R. (1993) Characterization of distinct islet protein auto antigens associated with type 1 diabetes. Autoimmunity, 15 (s1). pp. 1-3. ISSN 0891-6934

Brain Slices

Brooks, Keith J., Hargreaves, Iain P. and Bates, Timothy E. (2008) Protection of respiratory chain enzymes from ischaemic damage in adult rat brain slices. Neurochemical research, 33 (9). pp. 1711-1716. ISSN 0364-3190

Brain Tumour

Levicar, Natasa, Dewey, Ricardo A., Daley, Emma, Bates, Timothy E., Davies, Derek, Kos, Janko, Pilkington, Geoffrey J. and Lah, Tamara T. (2003) Selective suppression of cathepsin L by antisense cDNA impairs human brain tumor cell invasion in vitro and promotes apoptosis. Cancer Gene Therapy, 10 (2). pp. 141-51. ISSN 0929-1903

Breast Asymmetry

Janan, Faraz and Brady, Michael (2018) Focal Asymmetry and Laterality of Cancer in the "Selected Abstracts from the 2018 NCRI Cancer Conference of National Cancer Research Institute". British Journal of Cancer, 119 (1). pp. 1-49. ISSN 1532-1827

Breast Density

Janan, Faraz and Brady, Michael (2018) Focal Asymmetry and Laterality of Cancer in the "Selected Abstracts from the 2018 NCRI Cancer Conference of National Cancer Research Institute". British Journal of Cancer, 119 (1). pp. 1-49. ISSN 1532-1827

Breast cancer diagnosis

Janan, Faraz and Brady, Michael (2018) Focal Asymmetry and Laterality of Cancer in the "Selected Abstracts from the 2018 NCRI Cancer Conference of National Cancer Research Institute". British Journal of Cancer, 119 (1). pp. 1-49. ISSN 1532-1827

C peptide

Christie, Michael R., Molvig, Jens, Hawkes, Charlotte J., Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

C reactive protein

Winzer, Brooke M., Paratz, Jennifer D., Whitehead, Jonathan P., Whiteman, David C. and Reeves, Marina M. (2015) The feasibility of an exercise intervention in males at risk of oesophageal adenocarcinoma: a randomized controlled trial. PLoS ONE, 10 (2). ISSN 1932-6203

C-Peptide

Christie, M. R., Daneman, D., Champagne, P. and Delovitch, T. L. (1990) Persistence of serum antibodies to 64,000-Mr islet cell protein after onset of type I diabetes. Diabetes, 39 (6). pp. 653-656. ISSN 0012-1797

Christie, Michael R., Molvig, Jens, Hawkes, Charlotte J., Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

CALR

Boasman, Kristian, Simmonds, Matthew and Rinaldi, Ciro (2018) CALR and CD47: An insight into their roles in the disease progression of MDS and MPN. Journal of Blood Disorders & Transfusion . ISSN 2155-9864

CD47

Boasman, Kristian, Simmonds, Matthew and Rinaldi, Ciro (2018) CALR and CD47: An insight into their roles in the disease progression of MDS and MPN. Journal of Blood Disorders & Transfusion . ISSN 2155-9864

Ca2+

Keelan, Julie, Bates, Timothy E. and Clark, John B. (1996) Intrasynaptosomal free calcium concentration during rat brain development: effects of hypoxia, aglycaemia, and ischaemia. Journal of neurochemistry, 66 (6). pp. 2460-7. ISSN 0022-3042

Cadherin

Siamantouras, Eleftherios, Hills, Claire, Liu, Kuo-Kang and Squires, Paul (2020) Examining Cell-Cell Interactions in the Kidney Using AFM Single-Cell Force Spectroscopy. In: Diabetic Nephropathy. Methods in Molecular Biology, 2067 . Humana Press, Humana, New York, NY, pp. 189-201. ISBN 978-1-4939-9840-1, 978-1-4939-9841-8

Calcium

Keelan, Julie, Bates, Timothy E. and Clark, John B. (1996) Intrasynaptosomal free calcium concentration during rat brain development: effects of hypoxia, aglycaemia, and ischaemia. Journal of neurochemistry, 66 (6). pp. 2460-7. ISSN 0022-3042

Cancer

Akanuwe, Joseph, Siriwardena, Niro, Black, Sharon and Owen, Sara (2017) Informing use of QCancer in the primary care consultation - perspectives of service users and practitioners. In: Cancer Research Early Diagnosis Research Conference, 23th-24th February 2017, London.

Akanuwe, Joseph, Siriwardena, Niro, Black, Sharon and Owen, Sara (2017) A systematic scoping review of the use of cancer risk assessment tools for early detection of cancer risk in primary care. In: Society for Academic Primary Care (SAPC) Regional Conference, 21 March 2017, Lincoln.

Dagnelie, Pieter C., Bell, Jimmy D., Williams, Steve C., Bates, Timothy E., Abel, Paul D. and Foster, Christopher S. (1994) Effect of fish oil on cancer cachexia and host liver metabolism in rats with prostate tumors. Lipids, 29 (3). pp. 195-203. ISSN 0024-4201

Cancer risk assessment tools

Akanuwe, Joseph, Siriwardena, Niro, Black, Sharon and Owen, Sara (2017) Exploring service user and practitioner perspectives of using cancer risk assessment tools in primary care GP consultations. In: Society for Academic Primary Care (SAPC) ASM Conference, 12-14 July 2017, University of Warwick.

Carbohydrates

Payton, M. A., Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Cathepsin

Levicar, Natasa, Dewey, Ricardo A., Daley, Emma, Bates, Timothy E., Davies, Derek, Kos, Janko, Pilkington, Geoffrey J. and Lah, Tamara T. (2003) Selective suppression of cathepsin L by antisense cDNA impairs human brain tumor cell invasion in vitro and promotes apoptosis. Cancer Gene Therapy, 10 (2). pp. 141-51. ISSN 0929-1903

Cell Fractionation

Christie, M. R., Pipeleers, D. G., Lernmark, A. and Baekkeskov, S. (1990) Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes. Journal of Biological Chemistry, 265 (1). pp. 376-381. ISSN 0021-9258

Cell Line

Hawkes, C. J., Schloot, N. C., Marks, J., Willemen, S. J. M., Drijfhout, J. W., Mayer, E. K., Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

Cell Membrane

Christie, M. R., Pipeleers, D. G., Lernmark, A. and Baekkeskov, S. (1990) Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes. Journal of Biological Chemistry, 265 (1). pp. 376-381. ISSN 0021-9258

Christie, M. R., Vohra, G., Champagne, P., Daneman, D. and Delovitch, T. L. (1990) Distinct antibody specificities to a 64-kD islet cell antigen in Type 1 diabetes as revealed by trypsin treatment. Journal of Experimental Medicine, 172 (3). pp. 789-794. ISSN 0022-1007

Cell Proliferation

Zhao, M., Amiel, S. A., Christie, Michael R., Rela, M., Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Cell Transplantation

Zhao, M., Amiel, S. A., Christie, Michael R., Rela, M., Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Cell adhesion

Eves, Paula, Bullet, Nial A., Haddow, David, Beck, Alison J., Layton, Christopher, Way, Louise, Shard, Alex G., Gawkrodger, David J. and MacNeil, Sheila (2008) Simplifying the delivery of melanocytes and keratinocytes for the treatment of vitiligo using a chemically defined carrier dressing. Journal of Investigative Dermatology, 128 (6). pp. 1554-1564. ISSN 0022-202X

Siamantouras, Eleftherios, Price, Gareth, Potter, Joe, Hills, Claire and Squires, Paul (2019) Purinergic receptor (P2X7) activation reduces cell–cell adhesion between tubular epithelial cells of the proximal kidney. Nanomedicine: Nanotechnology, Biology and Medicine, 22 . ISSN 1549-9634

Cell carrier system

MacNeil, Sheila and Eves, Paula (2006) Simplifying the delivery of cultured melanocytes and keratinocytes for grafting patients with vitiligo. In: Surgical management of vitiligo. Blackwell Publishing Ltd, pp. 191-202. ISBN 1405145218, 9781405145213

Cell carrier system; Cultured melanocytes; Keratinocytes; Surface engineered carriers; Vitiligo grafting

MacNeil, Sheila and Eves, Paula (2006) Simplifying the delivery of cultured melanocytes and keratinocytes for grafting patients with vitiligo. In: Surgical management of vitiligo. Blackwell Publishing Ltd, pp. 191-202. ISBN 1405145218, 9781405145213

Cells, Cultured

Hansen, W.A., Christie, M.R., Kahn, R., Norgaard, A., Abel, I., Petersen, A.M., Jorgensen, D.W., Baekkeskov, S., Nielsen, J.H., Lernmark, A., Egeberg, J., Richter-Olesen, H., Grainger, T., Kristensen, J.K., Brynitz, S. and Bilde, T. (1989) Supravital dithizone staining in the isolation of human and rat pancreatic islets. Diabetes Research, 10 (2). pp. 53-57. ISSN 0265-5985

Zhao, M., Christie, M.R., Heaton, N., George, S., Amiel, S. and Huang, G.C. (2002) Amelioration of streptozotocin-induced diabetes in mice using human islet cells derived from long-term culture in vitro. Transplantation, 73 (9). pp. 1454-1460. ISSN 0041-1337

Zhao, M., Amiel, S. A., Christie, Michael R., Rela, M., Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Cellular stress response

Calabrese, Vittorio, Cornelius, Carolin, Mancuso, Cesare, Pennisi, Giovanni, Calafato, Stella, Bellia, Francesco, Bates, Timothy E., Giuffrida Stella, Anna Maria, Schapira, Tony, Dinkova Kostova, Albena T. and Rizzarelli, Enrico (2008) Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity. Neurochemical Research, 33 (12). pp. 2444-2471. ISSN 0364-3190

Centrifugation, Density Gradient

Christie, M. R., Pipeleers, D. G., Lernmark, A. and Baekkeskov, S. (1990) Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes. Journal of Biological Chemistry, 265 (1). pp. 376-381. ISSN 0021-9258

Charge transfer complex

ALHAJ SAKUR, Amir, Chalati, Tamim and Fael, Hanan (2015) NEW FLUORESCENCE QUENCHING BASED METHOD FOR THE DETERMINATION OF TRANDOLAPRIL IN BULK AND CAPSULES. International Journal of Pharmacy and Pharmaceutical Sciences, 7 (3). pp. 223-227. ISSN 0975-1491

Child

Christie, M. R., Daneman, D., Champagne, P. and Delovitch, T. L. (1990) Persistence of serum antibodies to 64,000-Mr islet cell protein after onset of type I diabetes. Diabetes, 39 (6). pp. 653-656. ISSN 0012-1797

Christie, M. R., Genovese, S., Cassidy, D., Bosi, E., Brown, T. J., Lai, M., Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

Christie, M. R., Tun, R. Y. M., Lo, S. S. S., Cassidy, D., Brown, T. J., Hollands, J., Shattock, M., Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Christie, M. R., Vohra, G., Champagne, P., Daneman, D. and Delovitch, T. L. (1990) Distinct antibody specificities to a 64-kD islet cell antigen in Type 1 diabetes as revealed by trypsin treatment. Journal of Experimental Medicine, 172 (3). pp. 789-794. ISSN 0022-1007

Gillespie, Kathleen M., Bain, Steven C., Barnett, Anthony H., Bingley, Polly J., Christie, Michael R., Gill, Geoffrey V. and Gale, Edwin A. M. (2004) The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. The Lancet, 364 (9446). pp. 1699-1700. ISSN 0140-6736

Morgenthaler, N. G., Seissler, J., Achenbach, P., Glawe, D., Payton, M., Meinck, H.-M., Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Child and adolescent mental health services

Golightley, Malcolm and Goemans, Robert (2017) Social work and mental health. 6th Edition. Transforming Social Work Practice . Learning Matters. ISBN 9781473989290

Child, Preschool

Bingley, P. J., Christie, M. R., Bonifacio, E., Bonfanti, R., Shattock, M., Fonte, M.-T., Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Christie, M. R., Genovese, S., Cassidy, D., Bosi, E., Brown, T. J., Lai, M., Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

Christie, M. R., Vohra, G., Champagne, P., Daneman, D. and Delovitch, T. L. (1990) Distinct antibody specificities to a 64-kD islet cell antigen in Type 1 diabetes as revealed by trypsin treatment. Journal of Experimental Medicine, 172 (3). pp. 789-794. ISSN 0022-1007

Christie, Michael R., Roll, Ursula, Payton, Mark A., Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Gillespie, Kathleen M., Bain, Steven C., Barnett, Anthony H., Bingley, Polly J., Christie, Michael R., Gill, Geoffrey V. and Gale, Edwin A. M. (2004) The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. The Lancet, 364 (9446). pp. 1699-1700. ISSN 0140-6736

Gorus, F. K., Goubert, P., Semakula, C., Vandewalle, C. L., De Schepper, J., Scheen, A., Christie, Michael R. and Pipeleers, D. G. (1997) IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia, 40 (1). pp. 95-99. ISSN 0012-186X

Gylling, Mikhail, Tuomi, Tiinamaija, Bjorses, Petra, Kontiainen, Sirkka, Partanen, Jukka, Christie, Michael R., Knip, Mikael, Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

Hatfield, E. C. I., Hawkes, C. J., Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Hawa, M., Rowe, R., Lan, M. S., Notkins, A. L., Pozzilli, P., Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Hawkes, C. J., Schloot, N. C., Marks, J., Willemen, S. J. M., Drijfhout, J. W., Mayer, E. K., Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

Morgenthaler, N. G., Löbner, K., Morgenthaler, U. Y., Christie, M. R., Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Morgenthaler, N. G., Seissler, J., Achenbach, P., Glawe, D., Payton, M., Meinck, H.-M., Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Roll, U., Christie, M. R., Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

Seissler, J., Morgenthaler, N. G., Achenbach, P., Lampeter, E .F., Glawe, D., Payton, M., Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

Winnock, Frederic, Christie, Michael R., Batstra, Manou R., Aanstoot, Henk-Jan, Weets, Ilse, Decochez, Katelijn, Jopart, Philippe, Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

Chronic Disease

Lampeter, E. F., Kolb, H., Seifert, I., Lohmann, D., Heise, J. W., Bertrams, J., Christie, Michael and Kolb-Bachofen, V. (1994) Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity. Diabetologia, 37 (5). pp. 471-475. ISSN 0012-186X

Clinical application

Klonizakis, Markos, Manning, Gillian and Donnelly, Richard (2011) Assessment of lower limb microcirculation: exploring the reproducibility and clinical application of laser doppler techniques. Skin Pharmacology and Physiology: Journal of Pharmacological and Biophysical Research, 24 (3). pp. 136-143. ISSN 1660-5527

Cloning, Molecular

Hawkes, C. J., Wasmeier, C., Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Payton, M. A., Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Coculture techniques

Eves, Paula, Bullet, Nial A., Haddow, David, Beck, Alison J., Layton, Christopher, Way, Louise, Shard, Alex G., Gawkrodger, David J. and MacNeil, Sheila (2008) Simplifying the delivery of melanocytes and keratinocytes for the treatment of vitiligo using a chemically defined carrier dressing. Journal of Investigative Dermatology, 128 (6). pp. 1554-1564. ISSN 0022-202X

Cohort Studies

Christie, M. R., Tun, R. Y. M., Lo, S. S. S., Cassidy, D., Brown, T. J., Hollands, J., Shattock, M., Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Gorus, F. K., Goubert, P., Semakula, C., Vandewalle, C. L., De Schepper, J., Scheen, A., Christie, Michael R. and Pipeleers, D. G. (1997) IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia, 40 (1). pp. 95-99. ISSN 0012-186X

Hawa, M., Rowe, R., Lan, M. S., Notkins, A. L., Pozzilli, P., Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Comparative Study

Christie, M. R. (1993) Characterization of distinct islet protein auto antigens associated with type 1 diabetes. Autoimmunity, 15 (s1). pp. 1-3. ISSN 0891-6934

Christie, M. R., Daneman, D., Champagne, P. and Delovitch, T. L. (1990) Persistence of serum antibodies to 64,000-Mr islet cell protein after onset of type I diabetes. Diabetes, 39 (6). pp. 653-656. ISSN 0012-1797

Christie, M. R., Tun, R. Y. M., Lo, S. S. S., Cassidy, D., Brown, T. J., Hollands, J., Shattock, M., Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Payton, M. A., Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Complex I

Bates, T. E., Heales, S. J., Davies, S. E., Boakye, P. and Clark, J. B. (1994) Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. Journal of neurochemistry, 63 (2). pp. 640-648. ISSN 0022-3042

Complexes

Heales, S. J., Davies, S. E., Bates, T. E. and Clark, J. B. (1995) Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration. Neurochemical research, 20 (1). pp. 31-38. ISSN 0364-3190

Compliance

Abuosi, A.A, Akoriyea, S.K, Kummi, G.N and Akanuwe, J (2019) Hand Hygiene Compliance Among Healthcare Workers in Ghana’s Health Care Institutions: Implications for Infection Prevention and Control. In: ISQUA 2019.

Abuosi, Aaron Asibi, Akoriyea, Samuel Kaba, Ntow-Kummi, Gloria, Akanuwe, Joseph, Abor, Patience Aseweh, Daniels, Anita Anima and Alhassan, Robert Kaba (2020) Hand hygiene compliance among healthcare workers in Ghana’s health care institutions: An observational study. Journal of Patient Safety and Risk Management, 25 (5). pp. 177-186. ISSN 2516-0435

Computer Vision

Janan, Faraz and Brady, Michael (2018) Focal Asymmetry and Laterality of Cancer in the "Selected Abstracts from the 2018 NCRI Cancer Conference of National Cancer Research Institute". British Journal of Cancer, 119 (1). pp. 1-49. ISSN 1532-1827

Coxsackie virus

Catani, Mara, Walther, Denise, Christie, Michael, McLaughlin, Kerry, Bonifacio, Ezio and Eugster, Anne (2015) Isolation of human monoclonal autoantibodies derived from pancreatic lymph node and peripheral blood B cells of islet autoantibody-positive patients. Diabetologia . ISSN 0012-186X

Cross Reactions

Hatfield, E. C. I., Hawkes, C. J., Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Hawkes, C. J., Wasmeier, C., Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Cross-Sectional Studies

Hawa, M., Rowe, R., Lan, M. S., Notkins, A. L., Pozzilli, P., Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Culture techniques

Eves, Paula, Bullet, Nial A., Haddow, David, Beck, Alison J., Layton, Christopher, Way, Louise, Shard, Alex G., Gawkrodger, David J. and MacNeil, Sheila (2008) Simplifying the delivery of melanocytes and keratinocytes for the treatment of vitiligo using a chemically defined carrier dressing. Journal of Investigative Dermatology, 128 (6). pp. 1554-1564. ISSN 0022-202X

Cultured melanocytes

MacNeil, Sheila and Eves, Paula (2006) Simplifying the delivery of cultured melanocytes and keratinocytes for grafting patients with vitiligo. In: Surgical management of vitiligo. Blackwell Publishing Ltd, pp. 191-202. ISBN 1405145218, 9781405145213

Cyclosporine

Christie, Michael R., Molvig, Jens, Hawkes, Charlotte J., Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

Cytokines

Hasnain, Sumaira Z., Borg, Danielle J., Harcourt, Brooke E., Tong, Hui, Sheng, Yonhua H., Ng, Choa ping, Das, Indrajit, Wang, Ran, Chen, Alice C.-H., Loudovaris, Thomas, Kay, Thomas W., Thomas, Helen E., Whitehead, Jonathan P., Forbes, Josephine M., Prins, Johannes B. and McGuckin, Michael A. (2014) Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress. Nature Medicine, 20 (12). pp. 1417-1426. ISSN 1078-8956

Cytoplasm

Hawkes, C. J., Schloot, N. C., Marks, J., Willemen, S. J. M., Drijfhout, J. W., Mayer, E. K., Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

Morgenthaler, N. G., Seissler, J., Achenbach, P., Glawe, D., Payton, M., Meinck, H.-M., Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

D2 receptor

Rosin, Claudia, Colombo, Sergio, Calver, Andrew A., Bates, Timothy E. and Skaper, Stephen D. (2005) Dopamine D2 and D3 receptor agonists limit oligodendrocyte injury caused by glutamate oxidative stress and oxygen/glucose deprivation. Glia, 52 (4). pp. 336-343. ISSN 0894-1491

D3 receptor

Rosin, Claudia, Colombo, Sergio, Calver, Andrew A., Bates, Timothy E. and Skaper, Stephen D. (2005) Dopamine D2 and D3 receptor agonists limit oligodendrocyte injury caused by glutamate oxidative stress and oxygen/glucose deprivation. Glia, 52 (4). pp. 336-343. ISSN 0894-1491

DALY

Rodriguez, Alina (2016) Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. The Lancet, 388 (10053). pp. 1659-1724. ISSN 0140-6736

DNA

De Silva, Maneka, Sebert, Sylvain, Couto Alves, Alex and Rodriguez, Alina (2017) Genetic architecture of early childhood growth phenotypes gives insights into their link with later obesity. bioRxiv . ISSN --

DNA Primers

Payton, M. A., Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Decision Trees

Bingley, P. J., Christie, M. R., Bonifacio, E., Bonfanti, R., Shattock, M., Fonte, M.-T., Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Delta-9-tetrahydrocannabinol

Athanasiou, Andriani, Clarke, Anna B., Turner, Amy E., Kumaran, Nethia M., Vakilpour, Sara, Smith, Paul A., Bagiokou, Dimitra, Bradshaw, Tracey D., Westwell, Andrew D., Fang, Lin, Lobo, Dileep N., Constantinescu, Cris S., Calabrese, Vittorio, Loesch, Andrzej, Alexander, Stephen P. H., Clothier, Richard H., Kendall, David A. and Bates, Timothy E. (2007) Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications, 364 (1). pp. 131-137. ISSN 0006-291x

Derivatization

Al-Haj Sakur, Amir, Chalati, Tamim and Fael, Hanan (2015) Selective Spectrofluorimetric Method for the Determination of Perindopril Erbumine in Bulk and Tablets through Derivatization with O-Phthalaldehyde in Presence of 3-Mercaptopropionic Acid. International Journal of Academic Scientific Research, 3 (2). pp. 26-37. ISSN 2272-6446

Development

Almeida, A., Brooks, K. J., Sammut, I., Keelan, J., Davey, G. P., Clark, J. B. and Bates, T. E. (1995) Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain. Developmental neuroscience, 17 (4). pp. 212-218. ISSN 0378-5866

Keelan, Julie, Bates, Timothy E. and Clark, John B. (1996) Intrasynaptosomal free calcium concentration during rat brain development: effects of hypoxia, aglycaemia, and ischaemia. Journal of neurochemistry, 66 (6). pp. 2460-7. ISSN 0022-3042

Diabetes

Christie, Michael (1999) Islet proteins implicated in pathogenesis of type 1 diabetes mellitus. Advances in Molecular and Cell Biology, 29 (C). pp. 75-100. ISSN 1569-2558

Squires, Paul, Siamantouras, Eleftherios, Potter, Joe, Price, Gareth and Hills, Claire (2019) ATP reduces functional cell-to-cell tethering between renal tubular epithelial cells. In: Physiology 2019 (The Physiological Society), 08/07/19-to-10/07/19, Aberdeen.

Diabetes Mellitus

Damanhouri, L. H., Dromey, J. A., Christie, Michael R., Nasrat, H. A., Ardawi, M. S. M., Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Diabetes Mellitus, Experimental

Huang, Guo Cai, Zhao, Min, Jones, Peter, Persaud, Shanta, Ramracheya, Reshma, Lobner, Kristian, Christie, Michael R., Banga, J. Paul, Peakman, Mark, Sirinivsan, Parthi, Rela, Mohammed, Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Zhao, M., Christie, M.R., Heaton, N., George, S., Amiel, S. and Huang, G.C. (2002) Amelioration of streptozotocin-induced diabetes in mice using human islet cells derived from long-term culture in vitro. Transplantation, 73 (9). pp. 1454-1460. ISSN 0041-1337

Zhao, M., Amiel, S. A., Christie, Michael R., Rela, M., Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Diabetes Mellitus, Insulin-Dependent

Baekkeskov, S., Warnock, G., Christie, M., Rajotte, R.V., Larsen, P.M. and Fey, S. (1989) Revelation of specificity of 64K autoantibodies in IDDM serums by high-resolution 2-D gel electrophoresis. Unambiguous identification of 64K target antigen. Diabetes, 38 (9). pp. 1133-1141. ISSN 0012-1797

Bottazzo, G. F., Genovese, S., Bosi, E., Dean, B. M., Christie, M. R. and Bonifacio, E. (1991) Novel considerations on the antibody/autoantigen system in type I (insulin-dependent) diabetes mellitus. Annals of Medicine, 23 (4). pp. 453-461. ISSN 0785-3890

Christie, M. R. (1993) Characterization of distinct islet protein auto antigens associated with type 1 diabetes. Autoimmunity, 15 (s1). pp. 1-3. ISSN 0891-6934

Christie, M. R., Daneman, D., Champagne, P. and Delovitch, T. L. (1990) Persistence of serum antibodies to 64,000-Mr islet cell protein after onset of type I diabetes. Diabetes, 39 (6). pp. 653-656. ISSN 0012-1797

Christie, M. R., Genovese, S., Cassidy, D., Bosi, E., Brown, T. J., Lai, M., Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

Christie, M. R., Pipeleers, D. G., Lernmark, A. and Baekkeskov, S. (1990) Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes. Journal of Biological Chemistry, 265 (1). pp. 376-381. ISSN 0021-9258

Christie, M. R., Tun, R. Y. M., Lo, S. S. S., Cassidy, D., Brown, T. J., Hollands, J., Shattock, M., Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Christie, M. R., Vohra, G., Champagne, P., Daneman, D. and Delovitch, T. L. (1990) Distinct antibody specificities to a 64-kD islet cell antigen in Type 1 diabetes as revealed by trypsin treatment. Journal of Experimental Medicine, 172 (3). pp. 789-794. ISSN 0022-1007

Christie, Michael, Brown, T. J. and Cassidy, D. (1992) Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme. Diabetologia, 35 (4). pp. 380-384. ISSN 0012-186X

Christie, Michael, Landin-Olsson, M., Sundkvist, G., Dahlquist, G., Lernmark, A. and Baekkeskov, S. (1988) Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes. Diabetologia, 31 (8). pp. 597-602. ISSN 0012-186X

Christie, M. R., Hollands, J. A., Brown, T. J., Michelsen, B. K. and Delovitch, T. L. (1993) Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. Journal of Clinical Investigation, 92 (1). pp. 240-248. ISSN 0021-9738

Payton, M. A., Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Roll, U., Christie, M. R., Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

Wagner, R., Genovese, S., Bosi, E., Becker, F., Bingley, P. J., Bonifacio, E., Miles, K. A., Christie, Michael, Bottazzo, G. F. and Gale, E. A. M. (1994) Slow metabolic deterioration towards diabetes in islet cell antibody positive patients with autoimmune polyendocrine disease. Diabetologia, 37 (4). pp. 365-371. ISSN 0012-186X

Diabetes Mellitus, Type 1

Bearzatto, Massimo, Naserke, Heike, Piquer, Sandra, Koczwara, Kerstin, Lampasona, Vito, Williams, Alistair, Christie, Michael R., Bingley, Polly J., Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Bingley, P. J., Christie, M. R., Bonifacio, E., Bonfanti, R., Shattock, M., Fonte, M.-T., Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Bonifacio, E. and Christie, M. R. (1997) Islet cell antigens in the prediction and prevention of insulin-dependent diabetes mellitus. Annals of Medicine, 29 (5). pp. 405-412. ISSN 0785-3890

Christie, M. R. (1996) Islet cell autoantigens in type 1 diabetes. European Journal of Clinical Investigation, 26 (10). pp. 827-838. ISSN 0014-2972

Christie, Michael R., Roll, Ursula, Payton, Mark A., Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Christie, Michael R., Molvig, Jens, Hawkes, Charlotte J., Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

Damanhouri, L. H., Dromey, J. A., Christie, Michael R., Nasrat, H. A., Ardawi, M. S. M., Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Desai, M.a, Cull, C.A.b, Horton, V.A.a, Christie, M.R.c, Bonifacio, E.d, Lampasona, V.d, Bingley, P.J.e, Levy, J.C.a, Mackay, I.R.f, Zimmet, P.g, Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Gillespie, Kathleen M., Bain, Steven C., Barnett, Anthony H., Bingley, Polly J., Christie, Michael R., Gill, Geoffrey V. and Gale, Edwin A. M. (2004) The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. The Lancet, 364 (9446). pp. 1699-1700. ISSN 0140-6736

Gorus, F. K., Goubert, P., Semakula, C., Vandewalle, C. L., De Schepper, J., Scheen, A., Christie, Michael R. and Pipeleers, D. G. (1997) IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia, 40 (1). pp. 95-99. ISSN 0012-186X

Gylling, Mikhail, Tuomi, Tiinamaija, Bjorses, Petra, Kontiainen, Sirkka, Partanen, Jukka, Christie, Michael R., Knip, Mikael, Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

Hatfield, E. C. I., Hawkes, C. J., Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Hawa, M., Rowe, R., Lan, M. S., Notkins, A. L., Pozzilli, P., Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Hawkes, C. J., Wasmeier, C., Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Hawkes, C. J., Schloot, N. C., Marks, J., Willemen, S. J. M., Drijfhout, J. W., Mayer, E. K., Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

Morgenthaler, N. G., Löbner, K., Morgenthaler, U. Y., Christie, M. R., Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Morgenthaler, N. G., Seissler, J., Achenbach, P., Glawe, D., Payton, M., Meinck, H.-M., Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Piquer, Sandra, Valera, Lionel, Lampasona, Vito, Jardin-Watelet, Benedicte, Roche, Stephanie, Granier, Claude, Roquet, Francoise, Christie, Michael R., Giordano, Tiziana, Malosio, Maria-Luisa, Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

Roll, U., Christie, M. R., Fuchtenbusch, M., Payton, M. A., Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Seissler, J., Morgenthaler, N. G., Achenbach, P., Lampeter, E .F., Glawe, D., Payton, M., Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

Tremble, Jennifer, Morgenthaler, Nils G., Vlug, Arjen, Powers, Alvin C., Christie, Michael R., Scherbaum, Werner A. and Banga, J. Paul (1997) Human B cells secreting immunoglobulin G to glutamic acid decarboxylase- 65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes. Journal of Clinical Endocrinology and Metabolism, 82 (8). pp. 2664-2670. ISSN 0021-972X

Winnock, Frederic, Christie, Michael R., Batstra, Manou R., Aanstoot, Henk-Jan, Weets, Ilse, Decochez, Katelijn, Jopart, Philippe, Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

Diabetes Mellitus, Type 2

Damanhouri, L. H., Dromey, J. A., Christie, Michael R., Nasrat, H. A., Ardawi, M. S. M., Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Hasnain, Sumaira Z., Borg, Danielle J., Harcourt, Brooke E., Tong, Hui, Sheng, Yonhua H., Ng, Choa ping, Das, Indrajit, Wang, Ran, Chen, Alice C.-H., Loudovaris, Thomas, Kay, Thomas W., Thomas, Helen E., Whitehead, Jonathan P., Forbes, Josephine M., Prins, Johannes B. and McGuckin, Michael A. (2014) Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress. Nature Medicine, 20 (12). pp. 1417-1426. ISSN 1078-8956

Diabetes, Gestational

Damanhouri, L. H., Dromey, J. A., Christie, Michael R., Nasrat, H. A., Ardawi, M. S. M., Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Roll, U., Christie, M. R., Fuchtenbusch, M., Payton, M. A., Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Dietary antioxidants

Calabrese, V., Bates, T. E. and Stella, A. M. (2000) NO synthase and NO-dependent signal pathways in brain aging and neurodegenerative disorders: the role of oxidant/antioxidant balance. Neurochemical Research, 25 (9-10). pp. 1315-41. ISSN 0364-3190

Disease Progression

Desai, M.a, Cull, C.A.b, Horton, V.A.a, Christie, M.R.c, Bonifacio, E.d, Lampasona, V.d, Bingley, P.J.e, Levy, J.C.a, Mackay, I.R.f, Zimmet, P.g, Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Disease Susceptibility

Lampeter, E. F., Kolb, H., Seifert, I., Lohmann, D., Heise, J. W., Bertrams, J., Christie, Michael and Kolb-Bachofen, V. (1994) Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity. Diabetologia, 37 (5). pp. 471-475. ISSN 0012-186X

Disease prediction

McLaughlin, Kerry A, Tombs, Melissa and Christie, Michael (2020) Autoimmunity to tetraspanin-7 in type 1 diabetes. Medical Microbiology and immunology . ISSN 0300-8584

Diseases in Twins

Bottazzo, G. F., Genovese, S., Bosi, E., Dean, B. M., Christie, M. R. and Bonifacio, E. (1991) Novel considerations on the antibody/autoantigen system in type I (insulin-dependent) diabetes mellitus. Annals of Medicine, 23 (4). pp. 453-461. ISSN 0785-3890

Christie, M. R., Tun, R. Y. M., Lo, S. S. S., Cassidy, D., Brown, T. J., Hollands, J., Shattock, M., Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Dithizone

Hansen, W.A., Christie, M.R., Kahn, R., Norgaard, A., Abel, I., Petersen, A.M., Jorgensen, D.W., Baekkeskov, S., Nielsen, J.H., Lernmark, A., Egeberg, J., Richter-Olesen, H., Grainger, T., Kristensen, J.K., Brynitz, S. and Bilde, T. (1989) Supravital dithizone staining in the isolation of human and rat pancreatic islets. Diabetes Research, 10 (2). pp. 53-57. ISSN 0265-5985

Drug Delivery

Horcajada, Patricia, Chalati, Tamim, Serre, Christian, Gillet, Brigitte, Sebrie, Catherine, Baati, Tarek, Eubank, Jarrod, Heurtaux, Daniela, Clayette, Pascal, Kreuz, Christine, Chang, Jong-San, Hwang, Young Kyu, Marsaud, Veronique, Bories, Phuong-Nhi, Cynober, Luc, Gil, Sophie, Ferey, Gerard, Couvreur, Patrick and Gref, Ruxandra (2010) Porous metal–organic-framework nanoscale carriers as a potential platform for drug delivery and imaging. Nature Materials, 9 . pp. 172-178. ISSN 1476-4660

Dyslexia

Asghar, Zahid and Siriwardena, Niro (2018) Performance of candidates with dyslexia in the Applied Knowledge Test for membership of the Royal College of General Practitioners. In: SAPC ASM 2017 - Warwick 46th annual scientific meeting, 12 - 14 July 2017, Warwick.

EM

Bates, T. E., Loesch, A., Burnstock, G. and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochemical and biophysical research communications, 218 (1). pp. 40-44. ISSN 0006-291X

ET

Rinaldi, Ciro, Martinelli, Vincenzo, Rinaldi, Paola, Ciancia, Rosanna and del Vecchio, Luigi (2008) GATA1 is overexpressed in patients with essential thrombocythemia and polycythemia vera but not in patients with primary myelofibrosis or chronic myelogenous leukemia. Leukemia & lymphoma, 49 (7). pp. 1416-1419. ISSN 1042-8194

EVI1

Laricchia-Robbio, Leopoldo, Fazzina, Raffaella, Li, Donglan, Rinaldi, Ciro, Sinha, Kisaly K., Chakraborty, Soumen and Nucifora, Giuseppina (2006) Point mutations in two EVI1 Zn fingers abolish EVI1-GATA1 interaction and allow erythroid differentiation of murine bone marrow cells. Molecular and cellular biology, 26 (20). pp. 7658-7666. ISSN 0270-7306

Laricchia-Robbio, Leopoldo, Premanand, Kavitha, Rinaldi, Ciro R. and Nucifora, Giuseppina (2009) EVI1 Impairs myelopoiesis by deregulation of PU.1 function. Cancer Research, 69 (4). pp. 1633-1642. ISSN 0008-5472

Senyuk, Vitalyi, Sinha, Kislay K., Li, Donglan, Rinaldi, Ciro R., Yanamandra, Sastry and Nucifora, Giuseppina (2007) Repression of RUNX1 activity by EVI1: a new role of EVI1 in leukemogenesis. Cancer research, 67 (12). pp. 5658-5666. ISSN 1538-7445

Electron Microscopy

Bates, T. E., Loesch, A., Burnstock, G. and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochemical and biophysical research communications, 218 (1). pp. 40-44. ISSN 0006-291X

Electron Transport Chain

Allen, Kathryn L., Almeida, Angeles, Bates, Timothy E. and Clark, John B. (1995) Changes of respiratory chain activity in mitochondrial and synaptosomal fractions isolated from the gerbil brain after graded ischaemia. Journal of neurochemistry, 64 (5). pp. 2222-2229. ISSN 0022-3042

Almeida, A., Brooks, K. J., Sammut, I., Keelan, J., Davey, G. P., Clark, J. B. and Bates, T. E. (1995) Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain. Developmental Neuroscience, 17 (4). pp. 212-218. ISSN 0378-5866

Almeida, A., Brooks, K. J., Sammut, I., Keelan, J., Davey, G. P., Clark, J. B. and Bates, T. E. (1995) Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain. Developmental neuroscience, 17 (4). pp. 212-218. ISSN 0378-5866

Almeida, Angeles, Allen, Kathryn L., Bates, TImothy E. and Clark, John B. (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. Journal of neurochemistry, 65 (4). pp. 1698-1703. ISSN 0022-3042

Electrophoresis, Gel, Two-Dimensional

Baekkeskov, S., Warnock, G., Christie, M., Rajotte, R.V., Larsen, P.M. and Fey, S. (1989) Revelation of specificity of 64K autoantibodies in IDDM serums by high-resolution 2-D gel electrophoresis. Unambiguous identification of 64K target antigen. Diabetes, 38 (9). pp. 1133-1141. ISSN 0012-1797

Christie, M. R., Hollands, J. A., Brown, T. J., Michelsen, B. K. and Delovitch, T. L. (1993) Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. Journal of Clinical Investigation, 92 (1). pp. 240-248. ISSN 0021-9738

Electrophoresis, Polyacrylamide Gel

Baekkeskov, S., Warnock, G., Christie, M., Rajotte, R.V., Larsen, P.M. and Fey, S. (1989) Revelation of specificity of 64K autoantibodies in IDDM serums by high-resolution 2-D gel electrophoresis. Unambiguous identification of 64K target antigen. Diabetes, 38 (9). pp. 1133-1141. ISSN 0012-1797

Emotional Distress

Hodgson, Jessica and Bretherton, Roger (2020) Twelve tips for novice academic staff supporting medical students in distress. Medical Teacher . ISSN 0142-159X

Endothelial BMPR-II

Long, Lu, Ormiston, Mark L., Yang, Xudong, Southwood, Mark, Gräf, Stefan, Machado, Rajiv D., Mueller, Matthias, Kinzel, Bernd, Yung, Lai Ming, Wilkinson, Janine M., Moore, Stephen D., Drake, Kylie M., Aldred, Micheala A., Yu, Paul B., Upton, Paul D. and Morrell, Nicholas W. (2015) Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension. Nature Medicine, 21 (7). pp. 777-785. ISSN 1078-8956

Endothelial cells

Long, Lu, Ormiston, Mark L., Yang, Xudong, Southwood, Mark, Gräf, Stefan, Machado, Rajiv D., Mueller, Matthias, Kinzel, Bernd, Yung, Lai Ming, Wilkinson, Janine M., Moore, Stephen D., Drake, Kylie M., Aldred, Micheala A., Yu, Paul B., Upton, Paul D. and Morrell, Nicholas W. (2015) Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension. Nature Medicine, 21 (7). pp. 777-785. ISSN 1078-8956

Endothelial function

Klonizakis, Markos, Manning, Gillian and Donnelly, Richard (2011) Assessment of lower limb microcirculation: exploring the reproducibility and clinical application of laser doppler techniques. Skin Pharmacology and Physiology: Journal of Pharmacological and Biophysical Research, 24 (3). pp. 136-143. ISSN 1660-5527

Epidermis

Eves, Paula, Bullet, Nial A., Haddow, David, Beck, Alison J., Layton, Christopher, Way, Louise, Shard, Alex G., Gawkrodger, David J. and MacNeil, Sheila (2008) Simplifying the delivery of melanocytes and keratinocytes for the treatment of vitiligo using a chemically defined carrier dressing. Journal of Investigative Dermatology, 128 (6). pp. 1554-1564. ISSN 0022-202X

Epilepsy

D'Amore, Valerio, von Randow, Constanze, Nicoletti, Ferdinando, Ngomba, Richard and van Luijtelaar, Gilles (2015) Anti-absence activity of mGlu1 and mGlu5 receptor enhancers and their interaction with a GABA reuptake inhibitor: effect of local infusions in the somatosensory cortex and thalamus. Epilepsia, 56 (7). pp. 1141-51. ISSN 0013-9580

Epitopes

Christie, M. R. (1996) Islet cell autoantigens in type 1 diabetes. European Journal of Clinical Investigation, 26 (10). pp. 827-838. ISSN 0014-2972

Desai, M.a, Cull, C.A.b, Horton, V.A.a, Christie, M.R.c, Bonifacio, E.d, Lampasona, V.d, Bingley, P.J.e, Levy, J.C.a, Mackay, I.R.f, Zimmet, P.g, Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Hatfield, E. C. I., Hawkes, C. J., Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Hawkes, C. J., Schloot, N. C., Marks, J., Willemen, S. J. M., Drijfhout, J. W., Mayer, E. K., Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

Morgenthaler, N. G., Löbner, K., Morgenthaler, U. Y., Christie, M. R., Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Piquer, Sandra, Valera, Lionel, Lampasona, Vito, Jardin-Watelet, Benedicte, Roche, Stephanie, Granier, Claude, Roquet, Francoise, Christie, Michael R., Giordano, Tiziana, Malosio, Maria-Luisa, Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

Richardson, Carolyn, McLaughlin, Kerry, Morgan, Diana, Feltbower, Richard and Christie, Michael (2016) Influence of HLA-DR and -DQ alleles on autoantibody recognition of distinct epitopes within the juxtamembrane domain of the IA-2 autoantigen in type 1 diabetes. Diabetologia, 59 (2). pp. 334-340. ISSN 0012-186X

Tremble, Jennifer, Morgenthaler, Nils G., Vlug, Arjen, Powers, Alvin C., Christie, Michael R., Scherbaum, Werner A. and Banga, J. Paul (1997) Human B cells secreting immunoglobulin G to glutamic acid decarboxylase- 65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes. Journal of Clinical Endocrinology and Metabolism, 82 (8). pp. 2664-2670. ISSN 0021-972X

Ethnicity

Asghar, Zahid and Siriwardena, Niro (2018) Performance of candidates with dyslexia in the Applied Knowledge Test for membership of the Royal College of General Practitioners. In: SAPC ASM 2017 - Warwick 46th annual scientific meeting, 12 - 14 July 2017, Warwick.

Exercise

Tew, G., Klonizakis, Markos and Saxton, G. (2010) Effects of ageing and fitness on skin-microvessel vasodilator function in humans. European Journal of Applied Physiology, 109 (2). pp. 173-181. ISSN 1439-6319

Family

Payton, M. A., Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Fathers

Roll, U., Christie, M. R., Fuchtenbusch, M., Payton, M. A., Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Fatty acide ethyl esters

Calabrese, V., Scapagnini, G., Catalano, C., Dinotta, F., Bates, T. E., Calvani, M. and Stella, A. M. (2001) Effects of acetyl-L-carnitine on the formation of fatty acid ethyl esters in brain and peripheral organs after short-term ethanol administration in rat. Neurochemical Research, 26 (2). pp. 167-74. ISSN 0364-3190

Female

Gorus, F. K., Goubert, P., Semakula, C., Vandewalle, C. L., De Schepper, J., Scheen, A., Christie, Michael R. and Pipeleers, D. G. (1997) IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia, 40 (1). pp. 95-99. ISSN 0012-186X

Hawkes, C. J., Schloot, N. C., Marks, J., Willemen, S. J. M., Drijfhout, J. W., Mayer, E. K., Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

Huang, Guo Cai, Zhao, Min, Jones, Peter, Persaud, Shanta, Ramracheya, Reshma, Lobner, Kristian, Christie, Michael R., Banga, J. Paul, Peakman, Mark, Sirinivsan, Parthi, Rela, Mohammed, Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Zhao, M., Amiel, S. A., Christie, Michael R., Rela, M., Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Fluorescein

ALHAJ SAKUR, Amir, Chalati, Tamim and Fael, Hanan (2015) NEW FLUORESCENCE QUENCHING BASED METHOD FOR THE DETERMINATION OF TRANDOLAPRIL IN BULK AND CAPSULES. International Journal of Pharmacy and Pharmaceutical Sciences, 7 (3). pp. 223-227. ISSN 0975-1491

Fluorescence quenching

ALHAJ SAKUR, Amir, Chalati, Tamim and Fael, Hanan (2015) NEW FLUORESCENCE QUENCHING BASED METHOD FOR THE DETERMINATION OF TRANDOLAPRIL IN BULK AND CAPSULES. International Journal of Pharmacy and Pharmaceutical Sciences, 7 (3). pp. 223-227. ISSN 0975-1491

Fluorescent Antibody Technique

Wagner, R., Genovese, S., Bosi, E., Becker, F., Bingley, P. J., Bonifacio, E., Miles, K. A., Christie, Michael, Bottazzo, G. F. and Gale, E. A. M. (1994) Slow metabolic deterioration towards diabetes in islet cell antibody positive patients with autoimmune polyendocrine disease. Diabetologia, 37 (4). pp. 365-371. ISSN 0012-186X

Fluorescent Antibody Technique, Indirect

Seissler, J., Morgenthaler, N. G., Achenbach, P., Lampeter, E .F., Glawe, D., Payton, M., Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

Tremble, Jennifer, Morgenthaler, Nils G., Vlug, Arjen, Powers, Alvin C., Christie, Michael R., Scherbaum, Werner A. and Banga, J. Paul (1997) Human B cells secreting immunoglobulin G to glutamic acid decarboxylase- 65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes. Journal of Clinical Endocrinology and Metabolism, 82 (8). pp. 2664-2670. ISSN 0021-972X

Focal Density

Janan, Faraz and Brady, Michael (2018) Focal Asymmetry and Laterality of Cancer in the "Selected Abstracts from the 2018 NCRI Cancer Conference of National Cancer Research Institute". British Journal of Cancer, 119 (1). pp. 1-49. ISSN 1532-1827

Follow-Up Studies

Bingley, P. J., Christie, M. R., Bonifacio, E., Bonfanti, R., Shattock, M., Fonte, M.-T., Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Christie, M. R., Tun, R. Y. M., Lo, S. S. S., Cassidy, D., Brown, T. J., Hollands, J., Shattock, M., Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Christie, Michael R., Roll, Ursula, Payton, Mark A., Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Christie, Michael R., Molvig, Jens, Hawkes, Charlotte J., Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

Desai, M.a, Cull, C.A.b, Horton, V.A.a, Christie, M.R.c, Bonifacio, E.d, Lampasona, V.d, Bingley, P.J.e, Levy, J.C.a, Mackay, I.R.f, Zimmet, P.g, Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Hawa, M., Rowe, R., Lan, M. S., Notkins, A. L., Pozzilli, P., Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Roll, U., Christie, M. R., Fuchtenbusch, M., Payton, M. A., Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Roll, U., Christie, M. R., Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

Seissler, J., Morgenthaler, N. G., Achenbach, P., Lampeter, E .F., Glawe, D., Payton, M., Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

Forecasting

Bonifacio, E. and Christie, M. R. (1997) Islet cell antigens in the prediction and prevention of insulin-dependent diabetes mellitus. Annals of Medicine, 29 (5). pp. 405-412. ISSN 0785-3890

GATA1

Rinaldi, Ciro, Martinelli, Vincenzo, Rinaldi, Paola, Ciancia, Rosanna and del Vecchio, Luigi (2008) GATA1 is overexpressed in patients with essential thrombocythemia and polycythemia vera but not in patients with primary myelofibrosis or chronic myelogenous leukemia. Leukemia & lymphoma, 49 (7). pp. 1416-1419. ISSN 1042-8194

GSH

Brooks, Keith J, Hargreaves, Iain, Bhakoo, Kishore, Sellwood, Mark, O'Brien, Francis, Noone, Martina, Sakata, Yasuko, Cady, Ernest, Wylezinska, Marzena, Thornton, John, Ordidge, Roger, Nguyen, Quyen, Clemence, Matthew, Wyatt, John and Bates, Timothy E. (2002) Delayed hypothermia prevents decreases in N-acetylaspartate and reduced glutathione in the cerebral cortex of the neonatal pig following transient hypoxia-ischaemia. Neurochemical Research, 27 (12). pp. 1599-604. ISSN 0364-3190

Calabrese, Vittorio, Testa, Guiseppe, Ravagna, Agrippino, Bates, Timothy Edward and Stella, Anna Maria (2000) HSP70 induction in the brain following ethanol administration in the rat: regulation by glutathione redox state. Biochemical and Biophysical Research Communications, 269 (2). pp. 397-400. ISSN 0006-291X

Heales, S. J., Davies, S. E., Bates, T. E. and Clark, J. B. (1995) Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration. Neurochemical research, 20 (1). pp. 31-38. ISSN 0364-3190

Kenyon, Susan H., Waterfield, Catherine J., Asker, Daniel S., Kudo, Mariko, Moss, David W., Bates, Timothy E., Nicolaou, Anna, Gibbons, William A. and Timbrell, John A. (1999) Effect of hydrazine upon vitamin B12-dependent methionine synthase activity and the sulphur amino acid pathway in isolated rat hepatocytes. Biochemical Pharmacology, 57 (11). pp. 1311-1319. ISSN 0006-2952

Gene Expression Regulation, Bacterial

Morgenthaler, N. G., Löbner, K., Morgenthaler, U. Y., Christie, M. R., Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Genes, MHC Class II

Gylling, Mikhail, Tuomi, Tiinamaija, Bjorses, Petra, Kontiainen, Sirkka, Partanen, Jukka, Christie, Michael R., Knip, Mikael, Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

Genetic Predisposition to Disease

Gillespie, Kathleen M., Bain, Steven C., Barnett, Anthony H., Bingley, Polly J., Christie, Michael R., Gill, Geoffrey V. and Gale, Edwin A. M. (2004) The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. The Lancet, 364 (9446). pp. 1699-1700. ISSN 0140-6736

Gerbil

Canevari, Laura, Console, Antonella, Tendi, E. A., Clark, J. B. and Bates, Timothy (1999) Effect of postischaemic hypothermia on the mitochondrial damage induced by ischaemia and reperfusion in the gerbil. Brain research, 817 (1-2). pp. 241-245. ISSN 0006-8993

Ghana

Abuosi, Aaron Asibi, Akoriyea, Samuel Kaba, Ntow-Kummi, Gloria, Akanuwe, Joseph, Abor, Patience Aseweh, Daniels, Anita Anima and Alhassan, Robert Kaba (2020) Hand hygiene compliance among healthcare workers in Ghana’s health care institutions: An observational study. Journal of Patient Safety and Risk Management, 25 (5). pp. 177-186. ISSN 2516-0435

Global Burden Disease

Rodriguez, Alina (2016) Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. The Lancet, 388 (10053). pp. 1659-1724. ISSN 0140-6736

Glucagon

Wagner, R., McNally, J. M., Bonifacio, E., Genovese, S., Foulis, A., McGill, M., Christie, M. R., Betterle, C., Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

Glucose

Zhao, M., Christie, M.R., Heaton, N., George, S., Amiel, S. and Huang, G.C. (2002) Amelioration of streptozotocin-induced diabetes in mice using human islet cells derived from long-term culture in vitro. Transplantation, 73 (9). pp. 1454-1460. ISSN 0041-1337

Glucose Tolerance Test

Christie, M. R., Tun, R. Y. M., Lo, S. S. S., Cassidy, D., Brown, T. J., Hollands, J., Shattock, M., Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Roll, U., Christie, M. R., Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

Zhao, M., Amiel, S. A., Christie, Michael R., Rela, M., Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Glutamate Decarboxylase

Christie, Michael, Brown, T. J. and Cassidy, D. (1992) Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme. Diabetologia, 35 (4). pp. 380-384. ISSN 0012-186X

Damanhouri, L. H., Dromey, J. A., Christie, Michael R., Nasrat, H. A., Ardawi, M. S. M., Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Desai, M.a, Cull, C.A.b, Horton, V.A.a, Christie, M.R.c, Bonifacio, E.d, Lampasona, V.d, Bingley, P.J.e, Levy, J.C.a, Mackay, I.R.f, Zimmet, P.g, Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Gorus, F. K., Goubert, P., Semakula, C., Vandewalle, C. L., De Schepper, J., Scheen, A., Christie, Michael R. and Pipeleers, D. G. (1997) IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia, 40 (1). pp. 95-99. ISSN 0012-186X

Payton, M. A., Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Roll, U., Christie, M. R., Fuchtenbusch, M., Payton, M. A., Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Wagner, R., Genovese, S., Bosi, E., Becker, F., Bingley, P. J., Bonifacio, E., Miles, K. A., Christie, Michael, Bottazzo, G. F. and Gale, E. A. M. (1994) Slow metabolic deterioration towards diabetes in islet cell antibody positive patients with autoimmune polyendocrine disease. Diabetologia, 37 (4). pp. 365-371. ISSN 0012-186X

Glutamate receptors

Rosin, Claudia, Bates, Timothy E. and Skaper, Stephen D. (2004) Excitatory amino acid induced oligodendrocyte cell death in vitro: receptor-dependent and -independent mechanisms. Journal of Neurochemistry, 90 (5). pp. 1173-1185. ISSN 0022-3042

Glutathione

Calabrese, Vittorio, Scapagnini, Giovanni, Ravagna, Agrippino, Bella, Rita, Foresti, Roberta, Bates, Timothy E., Giuffrida Stella, Anna-Maria and Pennisi, Giovanni (2002) Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels. Journal of Neuroscience Research, 70 (4). pp. 580-7. ISSN 0360-4012

Heales, S. J., Davies, S. E., Bates, T. E. and Clark, J. B. (1995) Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration. Neurochemical research, 20 (1). pp. 31-38. ISSN 0364-3190

Huang, Guo Cai, Zhao, Min, Jones, Peter, Persaud, Shanta, Ramracheya, Reshma, Lobner, Kristian, Christie, Michael R., Banga, J. Paul, Peakman, Mark, Sirinivsan, Parthi, Rela, Mohammed, Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Guillain-Barr?yndrome

Akanuwe, Joseph, Laparidou, Despina, Curtis, Ffion, Jackson, Jennifer, Hodgson, Timothy and Siriwardena, Niro (2020) Exploring the experiences of people living with Guillain-Barré Syndrome and its variants: a qualitative interview study. In: SAPC 2020 ASM.

Guillain-Barré Syndrome

Akanuwe, Joseph, Asghar, Zahid, Laparidou, Despina, Curtis, Ffion, Jackson, Jennifer, Hodgson, Timothy and Siriwardena, Niro (2020) Experiences of people following Guillain-Barre Syndrome and Associated Neuropathies: questionnaire development and validation. In: SAPC ASM.

Curtis, Ffion, Laparidou, Despina, Akanuwe, N.A Joseph, Ellis-Vowles, Victoria, Jackson, Jennifer, Senevirathna, Mahendra, Menezes, Igor, Hodgson, Timothy and Siriwardena, A. Niroshan (2019) Patient experiences and perceptions of Guillain-Barré Syndrome and associated inflammatory neuropathies following discharge from hospital. PROSPERO: International prospective register of systematic reviews .

Laparidou, Despina, Curtis, Ffion, Akanuwe, Joseph, Jackson, Jennifer, Hodgson, Timothy and Siriwardena, Niro (2020) Patients’ experiences and perceptions of Guillain-Barré syndrome: a systematic review and meta-synthesis of qualitative research. In: SAPC ASM.

H202

Bates, T. E., Heales, S. J., Davies, S. E., Boakye, P. and Clark, J. B. (1994) Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. Journal of neurochemistry, 63 (2). pp. 640-648. ISSN 0022-3042

H460

Athanasiou, Andriani, Clarke, Anna B., Turner, Amy E., Kumaran, Nethia M., Vakilpour, Sara, Smith, Paul A., Bagiokou, Dimitra, Bradshaw, Tracey D., Westwell, Andrew D., Fang, Lin, Lobo, Dileep N., Constantinescu, Cris S., Calabrese, Vittorio, Loesch, Andrzej, Alexander, Stephen P. H., Clothier, Richard H., Kendall, David A. and Bates, Timothy E. (2007) Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications, 364 (1). pp. 131-137. ISSN 0006-291x

Athanasiou, Andriani, Smith, Paul A., Vakilpour, Sara, Kumaran, Nethia M., Turner, Amy E., Bagiokou, Dimitra, Layfield, Robert, Ray, David E., Westwell, Andrew D., Alexander, Stephen P. H., Kendall, David A., Lobo, Dileep N., Watson, Susan A., Lophatanon, Artitaya, Muir, Kenneth A., Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

HIV/AIDS

Ahmed, Syed Imran, Ramach, Ashvinni, Ahmadi, Keivan, Hasan, Syed Shahzad and Lee, Christopher K. C. (2017) Evaluation of patient satisfaction with HIV/AIDS care and treatment: a cross-sectional study. European Journal for Person Centered Healthcare, 5 (1). ISSN 2052-5648

HLA Antigens

Hawkes, C. J., Schloot, N. C., Marks, J., Willemen, S. J. M., Drijfhout, J. W., Mayer, E. K., Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

HLA DQ antigen

Winnock, Frederic, Christie, Michael R., Batstra, Manou R., Aanstoot, Henk-Jan, Weets, Ilse, Decochez, Katelijn, Jopart, Philippe, Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

HLA DR1 antigen

Bearzatto, Massimo, Naserke, Heike, Piquer, Sandra, Koczwara, Kerstin, Lampasona, Vito, Williams, Alistair, Christie, Michael R., Bingley, Polly J., Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

HLA DR13 antigen

Bearzatto, Massimo, Naserke, Heike, Piquer, Sandra, Koczwara, Kerstin, Lampasona, Vito, Williams, Alistair, Christie, Michael R., Bingley, Polly J., Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

HLA DR3 antigen

Bearzatto, Massimo, Naserke, Heike, Piquer, Sandra, Koczwara, Kerstin, Lampasona, Vito, Williams, Alistair, Christie, Michael R., Bingley, Polly J., Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Lampeter, E. F., Kolb, H., Seifert, I., Lohmann, D., Heise, J. W., Bertrams, J., Christie, Michael and Kolb-Bachofen, V. (1994) Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity. Diabetologia, 37 (5). pp. 471-475. ISSN 0012-186X

HLA DR4 antigen

Bearzatto, Massimo, Naserke, Heike, Piquer, Sandra, Koczwara, Kerstin, Lampasona, Vito, Williams, Alistair, Christie, Michael R., Bingley, Polly J., Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

HLA DR4 antigen, adult

Lampeter, E. F., Kolb, H., Seifert, I., Lohmann, D., Heise, J. W., Bertrams, J., Christie, Michael and Kolb-Bachofen, V. (1994) Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity. Diabetologia, 37 (5). pp. 471-475. ISSN 0012-186X

HLA antigen

Bearzatto, Massimo, Naserke, Heike, Piquer, Sandra, Koczwara, Kerstin, Lampasona, Vito, Williams, Alistair, Christie, Michael R., Bingley, Polly J., Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

HLA antigen class 1

Wagner, R., McNally, J. M., Bonifacio, E., Genovese, S., Foulis, A., McGill, M., Christie, M. R., Betterle, C., Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

HLA antigen class 2

Gylling, Mikhail, Tuomi, Tiinamaija, Bjorses, Petra, Kontiainen, Sirkka, Partanen, Jukka, Christie, Michael R., Knip, Mikael, Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

Wagner, R., McNally, J. M., Bonifacio, E., Genovese, S., Foulis, A., McGill, M., Christie, M. R., Betterle, C., Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

HLA antigen class 2, adolescent

Gillespie, Kathleen M., Bain, Steven C., Barnett, Anthony H., Bingley, Polly J., Christie, Michael R., Gill, Geoffrey V. and Gale, Edwin A. M. (2004) The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. The Lancet, 364 (9446). pp. 1699-1700. ISSN 0140-6736

HLA system

Wagner, R., McNally, J. M., Bonifacio, E., Genovese, S., Foulis, A., McGill, M., Christie, M. R., Betterle, C., Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

HLA-D Antigens

Gorus, F. K., Goubert, P., Semakula, C., Vandewalle, C. L., De Schepper, J., Scheen, A., Christie, Michael R. and Pipeleers, D. G. (1997) IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia, 40 (1). pp. 95-99. ISSN 0012-186X

Wagner, R., McNally, J. M., Bonifacio, E., Genovese, S., Foulis, A., McGill, M., Christie, M. R., Betterle, C., Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

HLA-DQ Antigens

Gillespie, Kathleen M., Bain, Steven C., Barnett, Anthony H., Bingley, Polly J., Christie, Michael R., Gill, Geoffrey V. and Gale, Edwin A. M. (2004) The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. The Lancet, 364 (9446). pp. 1699-1700. ISSN 0140-6736

Richardson, Carolyn, McLaughlin, Kerry, Morgan, Diana, Feltbower, Richard and Christie, Michael (2016) Influence of HLA-DR and -DQ alleles on autoantibody recognition of distinct epitopes within the juxtamembrane domain of the IA-2 autoantigen in type 1 diabetes. Diabetologia, 59 (2). pp. 334-340. ISSN 0012-186X

Winnock, Frederic, Christie, Michael R., Batstra, Manou R., Aanstoot, Henk-Jan, Weets, Ilse, Decochez, Katelijn, Jopart, Philippe, Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

HLA-DR Antigens

Bearzatto, Massimo, Naserke, Heike, Piquer, Sandra, Koczwara, Kerstin, Lampasona, Vito, Williams, Alistair, Christie, Michael R., Bingley, Polly J., Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Gillespie, Kathleen M., Bain, Steven C., Barnett, Anthony H., Bingley, Polly J., Christie, Michael R., Gill, Geoffrey V. and Gale, Edwin A. M. (2004) The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. The Lancet, 364 (9446). pp. 1699-1700. ISSN 0140-6736

Richardson, Carolyn, McLaughlin, Kerry, Morgan, Diana, Feltbower, Richard and Christie, Michael (2016) Influence of HLA-DR and -DQ alleles on autoantibody recognition of distinct epitopes within the juxtamembrane domain of the IA-2 autoantigen in type 1 diabetes. Diabetologia, 59 (2). pp. 334-340. ISSN 0012-186X

HLA-DR3 Antigen

Lampeter, E. F., Kolb, H., Seifert, I., Lohmann, D., Heise, J. W., Bertrams, J., Christie, Michael and Kolb-Bachofen, V. (1994) Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity. Diabetologia, 37 (5). pp. 471-475. ISSN 0012-186X

HLA-DR4 Antigen

Lampeter, E. F., Kolb, H., Seifert, I., Lohmann, D., Heise, J. W., Bertrams, J., Christie, Michael and Kolb-Bachofen, V. (1994) Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity. Diabetologia, 37 (5). pp. 471-475. ISSN 0012-186X

HSP 70

Calabrese, Vittorio, Testa, Guiseppe, Ravagna, Agrippino, Bates, Timothy Edward and Stella, Anna Maria (2000) HSP70 induction in the brain following ethanol administration in the rat: regulation by glutathione redox state. Biochemical and Biophysical Research Communications, 269 (2). pp. 397-400. ISSN 0006-291X

HSP's

Calabrese, V., Scapagnini, G., Catalano, C., Bates, T. E., Geraci, D., Pennisi, G. and Giuffrida Stella, A. M. (2001) Regulation of heat shock protein synthesis in human skin fibroblasts in response to oxidative stress: role of vitamin E. International Journal of Tissue Reactions, 23 (4). pp. 127-35. ISSN 0250-0868

HU 210

Athanasiou, Andriani, Clarke, Anna B., Turner, Amy E., Kumaran, Nethia M., Vakilpour, Sara, Smith, Paul A., Bagiokou, Dimitra, Bradshaw, Tracey D., Westwell, Andrew D., Fang, Lin, Lobo, Dileep N., Constantinescu, Cris S., Calabrese, Vittorio, Loesch, Andrzej, Alexander, Stephen P. H., Clothier, Richard H., Kendall, David A. and Bates, Timothy E. (2007) Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications, 364 (1). pp. 131-137. ISSN 0006-291x

Haematological cancers

Boasman, Kristian, Simmonds, Matthew and Rinaldi, Ciro (2018) CALR and CD47: An insight into their roles in the disease progression of MDS and MPN. Journal of Blood Disorders & Transfusion . ISSN 2155-9864

Hand Hygiene

Abuosi, A.A, Akoriyea, S.K, Kummi, G.N and Akanuwe, J (2019) Hand Hygiene Compliance Among Healthcare Workers in Ghana’s Health Care Institutions: Implications for Infection Prevention and Control. In: ISQUA 2019.

Hand hygiene

Abuosi, Aaron Asibi, Akoriyea, Samuel Kaba, Ntow-Kummi, Gloria, Akanuwe, Joseph, Abor, Patience Aseweh, Daniels, Anita Anima and Alhassan, Robert Kaba (2020) Hand hygiene compliance among healthcare workers in Ghana’s health care institutions: An observational study. Journal of Patient Safety and Risk Management, 25 (5). pp. 177-186. ISSN 2516-0435

Haplotypes

Gillespie, Kathleen M., Bain, Steven C., Barnett, Anthony H., Bingley, Polly J., Christie, Michael R., Gill, Geoffrey V. and Gale, Edwin A. M. (2004) The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. The Lancet, 364 (9446). pp. 1699-1700. ISSN 0140-6736

Gylling, Mikhail, Tuomi, Tiinamaija, Bjorses, Petra, Kontiainen, Sirkka, Partanen, Jukka, Christie, Michael R., Knip, Mikael, Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

Lampeter, E. F., Kolb, H., Seifert, I., Lohmann, D., Heise, J. W., Bertrams, J., Christie, Michael and Kolb-Bachofen, V. (1994) Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity. Diabetologia, 37 (5). pp. 471-475. ISSN 0012-186X

Heart

Bates, T. E., Loesch, A., Burnstock, G. and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochemical and biophysical research communications, 218 (1). pp. 40-44. ISSN 0006-291X

Sammut, Ivan A., Jayakumar, Jay, Latif, Najmi, Rothery, Stephen, Severs, Nicholas J., Smolenski, Ryszard T., Bates, Timothy E. and Yacoub, Magdi H. (2001) Heat stress contributes to the enhancement of cardiac mitochondrial complex activity. The American Journal of Pathology, 158 (5). pp. 1821-31. ISSN 0002-9440

Heat

Tew, G., Klonizakis, Markos, Moss, J., Ruddock, A. D., Saxton, J. M. and Hodges, G. J. (2011) Reproducibility of cutaneous thermal hyperaemia assessed by laser Doppler flowmetry in young and older adults. Microvascular Research, 81 (2). pp. 177-182. ISSN 0026-2862

Heat Shock

Calabrese, V., Scapagnini, G., Catalano, C., Bates, T. E., Dinotta, F., Micali, G. and Giuffrida Stella, A. M. (2001) Induction of heat shock protein synthesis in human skin fibroblasts in response to oxidative stress: regulation by a natural antioxidant from rosemary extract. International Journal of Tissue Reactions, 23 (2). pp. 51-8. ISSN 0250-0868

Calabrese, V., Scapagnini, G., Catalano, C., Bates, T. E., Geraci, D., Pennisi, G. and Giuffrida Stella, A. M. (2001) Regulation of heat shock protein synthesis in human skin fibroblasts in response to oxidative stress: role of vitamin E. International Journal of Tissue Reactions, 23 (4). pp. 127-35. ISSN 0250-0868

Sammut, Ivan A., Jayakumar, Jay, Latif, Najmi, Rothery, Stephen, Severs, Nicholas J., Smolenski, Ryszard T., Bates, Timothy E. and Yacoub, Magdi H. (2001) Heat stress contributes to the enhancement of cardiac mitochondrial complex activity. The American Journal of Pathology, 158 (5). pp. 1821-31. ISSN 0002-9440

Heat-Shock Proteins

Christie, M. R., Hollands, J. A., Brown, T. J., Michelsen, B. K. and Delovitch, T. L. (1993) Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. Journal of Clinical Investigation, 92 (1). pp. 240-248. ISSN 0021-9738

Hemoglobin A, Glycosylated

Christie, Michael R., Molvig, Jens, Hawkes, Charlotte J., Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

Desai, M.a, Cull, C.A.b, Horton, V.A.a, Christie, M.R.c, Bonifacio, E.d, Lampasona, V.d, Bingley, P.J.e, Levy, J.C.a, Mackay, I.R.f, Zimmet, P.g, Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Hepatocytes

Kenyon, Susan H., Waterfield, Catherine J., Asker, Daniel S., Kudo, Mariko, Moss, David W., Bates, Timothy E., Nicolaou, Anna, Gibbons, William A. and Timbrell, John A. (1999) Effect of hydrazine upon vitamin B12-dependent methionine synthase activity and the sulphur amino acid pathway in isolated rat hepatocytes. Biochemical Pharmacology, 57 (11). pp. 1311-1319. ISSN 0006-2952

Histocompatibility Antigens Class I

Wagner, R., McNally, J. M., Bonifacio, E., Genovese, S., Foulis, A., McGill, M., Christie, M. R., Betterle, C., Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

Histocompatibility Antigens Class II

Gillespie, Kathleen M., Bain, Steven C., Barnett, Anthony H., Bingley, Polly J., Christie, Michael R., Gill, Geoffrey V. and Gale, Edwin A. M. (2004) The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. The Lancet, 364 (9446). pp. 1699-1700. ISSN 0140-6736

Homeodomain Proteins

Zhao, M., Amiel, S. A., Christie, Michael R., Rela, M., Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Humans

Bearzatto, Massimo, Naserke, Heike, Piquer, Sandra, Koczwara, Kerstin, Lampasona, Vito, Williams, Alistair, Christie, Michael R., Bingley, Polly J., Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Bingley, P. J., Christie, M. R., Bonifacio, E., Bonfanti, R., Shattock, M., Fonte, M.-T., Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Bonifacio, E. and Christie, M. R. (1997) Islet cell antigens in the prediction and prevention of insulin-dependent diabetes mellitus. Annals of Medicine, 29 (5). pp. 405-412. ISSN 0785-3890

Christie, M. R. (1996) Islet cell autoantigens in type 1 diabetes. European Journal of Clinical Investigation, 26 (10). pp. 827-838. ISSN 0014-2972

Christie, Michael R., Roll, Ursula, Payton, Mark A., Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Christie, Michael R., Molvig, Jens, Hawkes, Charlotte J., Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

Damanhouri, L. H., Dromey, J. A., Christie, Michael R., Nasrat, H. A., Ardawi, M. S. M., Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Desai, M.a, Cull, C.A.b, Horton, V.A.a, Christie, M.R.c, Bonifacio, E.d, Lampasona, V.d, Bingley, P.J.e, Levy, J.C.a, Mackay, I.R.f, Zimmet, P.g, Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Eves, Paula, Bullet, Nial A., Haddow, David, Beck, Alison J., Layton, Christopher, Way, Louise, Shard, Alex G., Gawkrodger, David J. and MacNeil, Sheila (2008) Simplifying the delivery of melanocytes and keratinocytes for the treatment of vitiligo using a chemically defined carrier dressing. Journal of Investigative Dermatology, 128 (6). pp. 1554-1564. ISSN 0022-202X

Gillespie, Kathleen M., Bain, Steven C., Barnett, Anthony H., Bingley, Polly J., Christie, Michael R., Gill, Geoffrey V. and Gale, Edwin A. M. (2004) The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. The Lancet, 364 (9446). pp. 1699-1700. ISSN 0140-6736

Gorus, F. K., Goubert, P., Semakula, C., Vandewalle, C. L., De Schepper, J., Scheen, A., Christie, Michael R. and Pipeleers, D. G. (1997) IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia, 40 (1). pp. 95-99. ISSN 0012-186X

Gylling, Mikhail, Tuomi, Tiinamaija, Bjorses, Petra, Kontiainen, Sirkka, Partanen, Jukka, Christie, Michael R., Knip, Mikael, Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

Hasnain, Sumaira Z., Borg, Danielle J., Harcourt, Brooke E., Tong, Hui, Sheng, Yonhua H., Ng, Choa ping, Das, Indrajit, Wang, Ran, Chen, Alice C.-H., Loudovaris, Thomas, Kay, Thomas W., Thomas, Helen E., Whitehead, Jonathan P., Forbes, Josephine M., Prins, Johannes B. and McGuckin, Michael A. (2014) Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress. Nature Medicine, 20 (12). pp. 1417-1426. ISSN 1078-8956

Hatfield, E. C. I., Hawkes, C. J., Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Hawa, M., Rowe, R., Lan, M. S., Notkins, A. L., Pozzilli, P., Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Hawkes, C. J., Schloot, N. C., Marks, J., Willemen, S. J. M., Drijfhout, J. W., Mayer, E. K., Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

Huang, Guo Cai, Zhao, Min, Jones, Peter, Persaud, Shanta, Ramracheya, Reshma, Lobner, Kristian, Christie, Michael R., Banga, J. Paul, Peakman, Mark, Sirinivsan, Parthi, Rela, Mohammed, Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Lampeter, E. F., Kolb, H., Seifert, I., Lohmann, D., Heise, J. W., Bertrams, J., Christie, Michael and Kolb-Bachofen, V. (1994) Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity. Diabetologia, 37 (5). pp. 471-475. ISSN 0012-186X

Morgenthaler, N. G., Löbner, K., Morgenthaler, U. Y., Christie, M. R., Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Morgenthaler, N. G., Seissler, J., Achenbach, P., Glawe, D., Payton, M., Meinck, H.-M., Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Roll, U., Christie, M. R., Fuchtenbusch, M., Payton, M. A., Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Seissler, J., Morgenthaler, N. G., Achenbach, P., Lampeter, E .F., Glawe, D., Payton, M., Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

Tremble, Jennifer, Morgenthaler, Nils G., Vlug, Arjen, Powers, Alvin C., Christie, Michael R., Scherbaum, Werner A. and Banga, J. Paul (1997) Human B cells secreting immunoglobulin G to glutamic acid decarboxylase- 65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes. Journal of Clinical Endocrinology and Metabolism, 82 (8). pp. 2664-2670. ISSN 0021-972X

Wagner, R., McNally, J. M., Bonifacio, E., Genovese, S., Foulis, A., McGill, M., Christie, M. R., Betterle, C., Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

Winnock, Frederic, Christie, Michael R., Batstra, Manou R., Aanstoot, Henk-Jan, Weets, Ilse, Decochez, Katelijn, Jopart, Philippe, Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

Zhao, M., Christie, M.R., Heaton, N., George, S., Amiel, S. and Huang, G.C. (2002) Amelioration of streptozotocin-induced diabetes in mice using human islet cells derived from long-term culture in vitro. Transplantation, 73 (9). pp. 1454-1460. ISSN 0041-1337

Zhao, M., Amiel, S. A., Christie, Michael R., Rela, M., Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Hydrogen peroxide

Bates, T. E., Heales, S. J., Davies, S. E., Boakye, P. and Clark, J. B. (1994) Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. Journal of neurochemistry, 63 (2). pp. 640-648. ISSN 0022-3042

Hydrolysis

Bearzatto, Massimo, Naserke, Heike, Piquer, Sandra, Koczwara, Kerstin, Lampasona, Vito, Williams, Alistair, Christie, Michael R., Bingley, Polly J., Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Hypoglycemic Agents

Christie, Michael R., Molvig, Jens, Hawkes, Charlotte J., Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

Hypothermia

Canevari, Laura, Console, Antonella, Tendi, E. A., Clark, J. B. and Bates, Timothy (1999) Effect of postischaemic hypothermia on the mitochondrial damage induced by ischaemia and reperfusion in the gerbil. Brain research, 817 (1-2). pp. 241-245. ISSN 0006-8993

IA 2 antigen

Piquer, Sandra, Valera, Lionel, Lampasona, Vito, Jardin-Watelet, Benedicte, Roche, Stephanie, Granier, Claude, Roquet, Francoise, Christie, Michael R., Giordano, Tiziana, Malosio, Maria-Luisa, Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

IA 2beta antigen

Piquer, Sandra, Valera, Lionel, Lampasona, Vito, Jardin-Watelet, Benedicte, Roche, Stephanie, Granier, Claude, Roquet, Francoise, Christie, Michael R., Giordano, Tiziana, Malosio, Maria-Luisa, Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

IA-2

Richardson, Carolyn, McLaughlin, Kerry, Morgan, Diana, Feltbower, Richard and Christie, Michael (2016) Influence of HLA-DR and -DQ alleles on autoantibody recognition of distinct epitopes within the juxtamembrane domain of the IA-2 autoantigen in type 1 diabetes. Diabetologia, 59 (2). pp. 334-340. ISSN 0012-186X

ICA512 autoantibody

Christie, Michael R., Molvig, Jens, Hawkes, Charlotte J., Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

Winnock, Frederic, Christie, Michael R., Batstra, Manou R., Aanstoot, Henk-Jan, Weets, Ilse, Decochez, Katelijn, Jopart, Philippe, Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

IL33 protein, human

Hasnain, Sumaira Z., Borg, Danielle J., Harcourt, Brooke E., Tong, Hui, Sheng, Yonhua H., Ng, Choa ping, Das, Indrajit, Wang, Ran, Chen, Alice C.-H., Loudovaris, Thomas, Kay, Thomas W., Thomas, Helen E., Whitehead, Jonathan P., Forbes, Josephine M., Prins, Johannes B. and McGuckin, Michael A. (2014) Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress. Nature Medicine, 20 (12). pp. 1417-1426. ISSN 1078-8956

IPTP

Levicar, Natasa, Dewey, Ricardo A., Daley, Emma, Bates, Timothy E., Davies, Derek, Kos, Janko, Pilkington, Geoffrey J. and Lah, Tamara T. (2003) Selective suppression of cathepsin L by antisense cDNA impairs human brain tumor cell invasion in vitro and promotes apoptosis. Cancer Gene Therapy, 10 (2). pp. 141-51. ISSN 0929-1903

Ia 2 antigen

Bearzatto, Massimo, Naserke, Heike, Piquer, Sandra, Koczwara, Kerstin, Lampasona, Vito, Williams, Alistair, Christie, Michael R., Bingley, Polly J., Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Ia antibody

Christie, Michael R., Molvig, Jens, Hawkes, Charlotte J., Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

Damanhouri, L. H., Dromey, J. A., Christie, Michael R., Nasrat, H. A., Ardawi, M. S. M., Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Gylling, Mikhail, Tuomi, Tiinamaija, Bjorses, Petra, Kontiainen, Sirkka, Partanen, Jukka, Christie, Michael R., Knip, Mikael, Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

Ia antigen

Bearzatto, Massimo, Naserke, Heike, Piquer, Sandra, Koczwara, Kerstin, Lampasona, Vito, Williams, Alistair, Christie, Michael R., Bingley, Polly J., Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Piquer, Sandra, Valera, Lionel, Lampasona, Vito, Jardin-Watelet, Benedicte, Roche, Stephanie, Granier, Claude, Roquet, Francoise, Christie, Michael R., Giordano, Tiziana, Malosio, Maria-Luisa, Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

Image Processing

Janan, Faraz and Brady, Michael (2018) Focal Asymmetry and Laterality of Cancer in the "Selected Abstracts from the 2018 NCRI Cancer Conference of National Cancer Research Institute". British Journal of Cancer, 119 (1). pp. 1-49. ISSN 1532-1827

Immumnoelectron microscopy

Bates, T. E., Loesch, A., Burnstock, G. and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochemical and biophysical research communications, 218 (1). pp. 40-44. ISSN 0006-291X

Immunocytochemistry

Bates, T. E., Loesch, A., Burnstock, G. and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochemical and biophysical research communications, 218 (1). pp. 40-44. ISSN 0006-291X

Immunodominant Epitopes

Bearzatto, Massimo, Naserke, Heike, Piquer, Sandra, Koczwara, Kerstin, Lampasona, Vito, Williams, Alistair, Christie, Michael R., Bingley, Polly J., Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Hawkes, C. J., Schloot, N. C., Marks, J., Willemen, S. J. M., Drijfhout, J. W., Mayer, E. K., Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

Immunoglobulin G

Tremble, Jennifer, Morgenthaler, Nils G., Vlug, Arjen, Powers, Alvin C., Christie, Michael R., Scherbaum, Werner A. and Banga, J. Paul (1997) Human B cells secreting immunoglobulin G to glutamic acid decarboxylase- 65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes. Journal of Clinical Endocrinology and Metabolism, 82 (8). pp. 2664-2670. ISSN 0021-972X

Immunohistochemistry

Piquer, Sandra, Valera, Lionel, Lampasona, Vito, Jardin-Watelet, Benedicte, Roche, Stephanie, Granier, Claude, Roquet, Francoise, Christie, Michael R., Giordano, Tiziana, Malosio, Maria-Luisa, Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

Immunology

Christie, Michael (1999) Islet proteins implicated in pathogenesis of type 1 diabetes mellitus. Advances in Molecular and Cell Biology, 29 (C). pp. 75-100. ISSN 1569-2558

McLaughlin, Kerry A., Richardson, Carolyn C., Williams, Stefan, Bonifacio, Ezio, Morgan, Diana, Feltbower, Richard G., Powell, Michael, Rees Smith, Bernard, Furmaniak, Jadwiga and Christie, Michael R. (2015) Relationships between major epitopes of the IA-2 autoantigen in Type 1 diabetes: implications for determinant spreading. Clinical Immunology, 160 (2). pp. 226-236. ISSN 1521-6616

Immunoprecipitation

Piquer, Sandra, Valera, Lionel, Lampasona, Vito, Jardin-Watelet, Benedicte, Roche, Stephanie, Granier, Claude, Roquet, Francoise, Christie, Michael R., Giordano, Tiziana, Malosio, Maria-Luisa, Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

Immunosorbent Techniques

Christie, M. R., Pipeleers, D. G., Lernmark, A. and Baekkeskov, S. (1990) Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes. Journal of Biological Chemistry, 265 (1). pp. 376-381. ISSN 0021-9258

Tremble, Jennifer, Morgenthaler, Nils G., Vlug, Arjen, Powers, Alvin C., Christie, Michael R., Scherbaum, Werner A. and Banga, J. Paul (1997) Human B cells secreting immunoglobulin G to glutamic acid decarboxylase- 65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes. Journal of Clinical Endocrinology and Metabolism, 82 (8). pp. 2664-2670. ISSN 0021-972X

Immunosuppressive Agents

Christie, Michael R., Molvig, Jens, Hawkes, Charlotte J., Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

Infant

Hawkes, C. J., Schloot, N. C., Marks, J., Willemen, S. J. M., Drijfhout, J. W., Mayer, E. K., Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

Morgenthaler, N. G., Löbner, K., Morgenthaler, U. Y., Christie, M. R., Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Morgenthaler, N. G., Seissler, J., Achenbach, P., Glawe, D., Payton, M., Meinck, H.-M., Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Infant, Newborn

Roll, U., Christie, M. R., Fuchtenbusch, M., Payton, M. A., Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Infection control

Abuosi, Aaron Asibi, Akoriyea, Samuel Kaba, Ntow-Kummi, Gloria, Akanuwe, Joseph, Abor, Patience Aseweh, Daniels, Anita Anima and Alhassan, Robert Kaba (2020) Hand hygiene compliance among healthcare workers in Ghana’s health care institutions: An observational study. Journal of Patient Safety and Risk Management, 25 (5). pp. 177-186. ISSN 2516-0435

Infection prevention and control

Abuosi, A.A, Akoriyea, S.K, Kummi, G.N and Akanuwe, J (2019) Hand Hygiene Compliance Among Healthcare Workers in Ghana’s Health Care Institutions: Implications for Infection Prevention and Control. In: ISQUA 2019.

Insulin

Hansen, W.A., Christie, M.R., Kahn, R., Norgaard, A., Abel, I., Petersen, A.M., Jorgensen, D.W., Baekkeskov, S., Nielsen, J.H., Lernmark, A., Egeberg, J., Richter-Olesen, H., Grainger, T., Kristensen, J.K., Brynitz, S. and Bilde, T. (1989) Supravital dithizone staining in the isolation of human and rat pancreatic islets. Diabetes Research, 10 (2). pp. 53-57. ISSN 0265-5985

Lampeter, E. F., Kolb, H., Seifert, I., Lohmann, D., Heise, J. W., Bertrams, J., Christie, Michael and Kolb-Bachofen, V. (1994) Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity. Diabetologia, 37 (5). pp. 471-475. ISSN 0012-186X

Wagner, R., McNally, J. M., Bonifacio, E., Genovese, S., Foulis, A., McGill, M., Christie, M. R., Betterle, C., Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

Insulin Antibodies

Baekkeskov, S., Warnock, G., Christie, M., Rajotte, R.V., Larsen, P.M. and Fey, S. (1989) Revelation of specificity of 64K autoantibodies in IDDM serums by high-resolution 2-D gel electrophoresis. Unambiguous identification of 64K target antigen. Diabetes, 38 (9). pp. 1133-1141. ISSN 0012-1797

Bottazzo, G. F., Genovese, S., Bosi, E., Dean, B. M., Christie, M. R. and Bonifacio, E. (1991) Novel considerations on the antibody/autoantigen system in type I (insulin-dependent) diabetes mellitus. Annals of Medicine, 23 (4). pp. 453-461. ISSN 0785-3890

Christie, Michael R., Roll, Ursula, Payton, Mark A., Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Lampeter, E. F., Kolb, H., Seifert, I., Lohmann, D., Heise, J. W., Bertrams, J., Christie, Michael and Kolb-Bachofen, V. (1994) Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity. Diabetologia, 37 (5). pp. 471-475. ISSN 0012-186X

Roll, U., Christie, M. R., Fuchtenbusch, M., Payton, M. A., Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Wagner, R., Genovese, S., Bosi, E., Becker, F., Bingley, P. J., Bonifacio, E., Miles, K. A., Christie, Michael, Bottazzo, G. F. and Gale, E. A. M. (1994) Slow metabolic deterioration towards diabetes in islet cell antibody positive patients with autoimmune polyendocrine disease. Diabetologia, 37 (4). pp. 365-371. ISSN 0012-186X

Insulin-Secreting Cells

Hasnain, Sumaira Z., Borg, Danielle J., Harcourt, Brooke E., Tong, Hui, Sheng, Yonhua H., Ng, Choa ping, Das, Indrajit, Wang, Ran, Chen, Alice C.-H., Loudovaris, Thomas, Kay, Thomas W., Thomas, Helen E., Whitehead, Jonathan P., Forbes, Josephine M., Prins, Johannes B. and McGuckin, Michael A. (2014) Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress. Nature Medicine, 20 (12). pp. 1417-1426. ISSN 1078-8956

Interferon gamma

Moss, David W. and Bates, Timothy E. (2001) Activation of murine microglial cell lines by lipopolysaccharide and interferon-gamma causes NO-mediated decreases in mitochondrial and cellular function. The European Journal of Neuroscience, 13 (3). pp. 529-38. ISSN 0953-816X

Interleukin-23

Hasnain, Sumaira Z., Borg, Danielle J., Harcourt, Brooke E., Tong, Hui, Sheng, Yonhua H., Ng, Choa ping, Das, Indrajit, Wang, Ran, Chen, Alice C.-H., Loudovaris, Thomas, Kay, Thomas W., Thomas, Helen E., Whitehead, Jonathan P., Forbes, Josephine M., Prins, Johannes B. and McGuckin, Michael A. (2014) Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress. Nature Medicine, 20 (12). pp. 1417-1426. ISSN 1078-8956

Interleukins

Hasnain, Sumaira Z., Borg, Danielle J., Harcourt, Brooke E., Tong, Hui, Sheng, Yonhua H., Ng, Choa ping, Das, Indrajit, Wang, Ran, Chen, Alice C.-H., Loudovaris, Thomas, Kay, Thomas W., Thomas, Helen E., Whitehead, Jonathan P., Forbes, Josephine M., Prins, Johannes B. and McGuckin, Michael A. (2014) Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress. Nature Medicine, 20 (12). pp. 1417-1426. ISSN 1078-8956

Iodine Radioisotopes

Morgenthaler, N. G., Löbner, K., Morgenthaler, U. Y., Christie, M. R., Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Iontophoresis

Klonizakis, Markos, Manning, Gillian and Donnelly, Richard (2011) Assessment of lower limb microcirculation: exploring the reproducibility and clinical application of laser doppler techniques. Skin Pharmacology and Physiology: Journal of Pharmacological and Biophysical Research, 24 (3). pp. 136-143. ISSN 1660-5527

Ischaemia

Allen, Kathryn L., Almeida, Angeles, Bates, Timothy E. and Clark, John B. (1995) Changes of respiratory chain activity in mitochondrial and synaptosomal fractions isolated from the gerbil brain after graded ischaemia. Journal of neurochemistry, 64 (5). pp. 2222-2229. ISSN 0022-3042

Almeida, Angeles, Allen, Kathryn L., Bates, TImothy E. and Clark, John B. (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. Journal of neurochemistry, 65 (4). pp. 1698-1703. ISSN 0022-3042

Brooks, Keith J., Hargreaves, Iain P. and Bates, Timothy E. (2008) Protection of respiratory chain enzymes from ischaemic damage in adult rat brain slices. Neurochemical research, 33 (9). pp. 1711-1716. ISSN 0364-3190

Ischemia

Allen, Kathryn L., Almeida, Angeles, Bates, Timothy E. and Clark, John B. (1995) Changes of respiratory chain activity in mitochondrial and synaptosomal fractions isolated from the gerbil brain after graded ischaemia. Journal of neurochemistry, 64 (5). pp. 2222-2229. ISSN 0022-3042

Almeida, Angeles, Allen, Kathryn L., Bates, TImothy E. and Clark, John B. (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. Journal of neurochemistry, 65 (4). pp. 1698-1703. ISSN 0022-3042

Brooks, Keith J, Hargreaves, Iain, Bhakoo, Kishore, Sellwood, Mark, O'Brien, Francis, Noone, Martina, Sakata, Yasuko, Cady, Ernest, Wylezinska, Marzena, Thornton, John, Ordidge, Roger, Nguyen, Quyen, Clemence, Matthew, Wyatt, John and Bates, Timothy E. (2002) Delayed hypothermia prevents decreases in N-acetylaspartate and reduced glutathione in the cerebral cortex of the neonatal pig following transient hypoxia-ischaemia. Neurochemical Research, 27 (12). pp. 1599-604. ISSN 0364-3190

Brooks, Keith J., Hargreaves, Iain P. and Bates, Timothy E. (2008) Protection of respiratory chain enzymes from ischaemic damage in adult rat brain slices. Neurochemical research, 33 (9). pp. 1711-1716. ISSN 0364-3190

Kuroda, Satoshi, Katsura, Ken-ichiro, Hillered, Lars, Bates, Timothy E. and Siesjö, Bo K. (1996) Delayed treatment with alpha-phenyl-N-tert-butyl nitrone (PBN) attenuates secondary mitochondrial dysfunction after transient focal cerebral ischemia in the rat. Neurobiology of Disease, 3 (2). pp. 149-157. ISSN 0969-9961

Islets of Langerhans

Baekkeskov, S., Warnock, G., Christie, M., Rajotte, R.V., Larsen, P.M. and Fey, S. (1989) Revelation of specificity of 64K autoantibodies in IDDM serums by high-resolution 2-D gel electrophoresis. Unambiguous identification of 64K target antigen. Diabetes, 38 (9). pp. 1133-1141. ISSN 0012-1797

Bearzatto, Massimo, Naserke, Heike, Piquer, Sandra, Koczwara, Kerstin, Lampasona, Vito, Williams, Alistair, Christie, Michael R., Bingley, Polly J., Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Bingley, P. J., Christie, M. R., Bonifacio, E., Bonfanti, R., Shattock, M., Fonte, M.-T., Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Bonifacio, E. and Christie, M. R. (1997) Islet cell antigens in the prediction and prevention of insulin-dependent diabetes mellitus. Annals of Medicine, 29 (5). pp. 405-412. ISSN 0785-3890

Bottazzo, G. F., Genovese, S., Bosi, E., Dean, B. M., Christie, M. R. and Bonifacio, E. (1991) Novel considerations on the antibody/autoantigen system in type I (insulin-dependent) diabetes mellitus. Annals of Medicine, 23 (4). pp. 453-461. ISSN 0785-3890

Christie, M. R. (1993) Characterization of distinct islet protein auto antigens associated with type 1 diabetes. Autoimmunity, 15 (s1). pp. 1-3. ISSN 0891-6934

Christie, M. R. (1996) Islet cell autoantigens in type 1 diabetes. European Journal of Clinical Investigation, 26 (10). pp. 827-838. ISSN 0014-2972

Christie, M. R., Daneman, D., Champagne, P. and Delovitch, T. L. (1990) Persistence of serum antibodies to 64,000-Mr islet cell protein after onset of type I diabetes. Diabetes, 39 (6). pp. 653-656. ISSN 0012-1797

Christie, M. R., Genovese, S., Cassidy, D., Bosi, E., Brown, T. J., Lai, M., Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

Christie, M. R., Pipeleers, D. G., Lernmark, A. and Baekkeskov, S. (1990) Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes. Journal of Biological Chemistry, 265 (1). pp. 376-381. ISSN 0021-9258

Christie, M. R., Tun, R. Y. M., Lo, S. S. S., Cassidy, D., Brown, T. J., Hollands, J., Shattock, M., Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Christie, M. R., Vohra, G., Champagne, P., Daneman, D. and Delovitch, T. L. (1990) Distinct antibody specificities to a 64-kD islet cell antigen in Type 1 diabetes as revealed by trypsin treatment. Journal of Experimental Medicine, 172 (3). pp. 789-794. ISSN 0022-1007

Christie, Michael, Brown, T. J. and Cassidy, D. (1992) Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme. Diabetologia, 35 (4). pp. 380-384. ISSN 0012-186X

Christie, Michael, Landin-Olsson, M., Sundkvist, G., Dahlquist, G., Lernmark, A. and Baekkeskov, S. (1988) Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes. Diabetologia, 31 (8). pp. 597-602. ISSN 0012-186X

Christie, Michael R., Roll, Ursula, Payton, Mark A., Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Christie, M. R., Hollands, J. A., Brown, T. J., Michelsen, B. K. and Delovitch, T. L. (1993) Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. Journal of Clinical Investigation, 92 (1). pp. 240-248. ISSN 0021-9738

Gorus, F. K., Goubert, P., Semakula, C., Vandewalle, C. L., De Schepper, J., Scheen, A., Christie, Michael R. and Pipeleers, D. G. (1997) IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia, 40 (1). pp. 95-99. ISSN 0012-186X

Gylling, Mikhail, Tuomi, Tiinamaija, Bjorses, Petra, Kontiainen, Sirkka, Partanen, Jukka, Christie, Michael R., Knip, Mikael, Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

Hansen, W.A., Christie, M.R., Kahn, R., Norgaard, A., Abel, I., Petersen, A.M., Jorgensen, D.W., Baekkeskov, S., Nielsen, J.H., Lernmark, A., Egeberg, J., Richter-Olesen, H., Grainger, T., Kristensen, J.K., Brynitz, S. and Bilde, T. (1989) Supravital dithizone staining in the isolation of human and rat pancreatic islets. Diabetes Research, 10 (2). pp. 53-57. ISSN 0265-5985

Hasnain, Sumaira Z., Borg, Danielle J., Harcourt, Brooke E., Tong, Hui, Sheng, Yonhua H., Ng, Choa ping, Das, Indrajit, Wang, Ran, Chen, Alice C.-H., Loudovaris, Thomas, Kay, Thomas W., Thomas, Helen E., Whitehead, Jonathan P., Forbes, Josephine M., Prins, Johannes B. and McGuckin, Michael A. (2014) Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress. Nature Medicine, 20 (12). pp. 1417-1426. ISSN 1078-8956

Hawa, M., Rowe, R., Lan, M. S., Notkins, A. L., Pozzilli, P., Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Hawkes, C. J., Wasmeier, C., Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Huang, Guo Cai, Zhao, Min, Jones, Peter, Persaud, Shanta, Ramracheya, Reshma, Lobner, Kristian, Christie, Michael R., Banga, J. Paul, Peakman, Mark, Sirinivsan, Parthi, Rela, Mohammed, Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Lampeter, E. F., Kolb, H., Seifert, I., Lohmann, D., Heise, J. W., Bertrams, J., Christie, Michael and Kolb-Bachofen, V. (1994) Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity. Diabetologia, 37 (5). pp. 471-475. ISSN 0012-186X

Morgenthaler, N. G., Seissler, J., Achenbach, P., Glawe, D., Payton, M., Meinck, H.-M., Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Payton, M. A., Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Roll, U., Christie, M. R., Fuchtenbusch, M., Payton, M. A., Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Roll, U., Christie, M. R., Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

Seissler, J., Morgenthaler, N. G., Achenbach, P., Lampeter, E .F., Glawe, D., Payton, M., Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

Tremble, Jennifer, Morgenthaler, Nils G., Vlug, Arjen, Powers, Alvin C., Christie, Michael R., Scherbaum, Werner A. and Banga, J. Paul (1997) Human B cells secreting immunoglobulin G to glutamic acid decarboxylase- 65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes. Journal of Clinical Endocrinology and Metabolism, 82 (8). pp. 2664-2670. ISSN 0021-972X

Wagner, R., Genovese, S., Bosi, E., Becker, F., Bingley, P. J., Bonifacio, E., Miles, K. A., Christie, Michael, Bottazzo, G. F. and Gale, E. A. M. (1994) Slow metabolic deterioration towards diabetes in islet cell antibody positive patients with autoimmune polyendocrine disease. Diabetologia, 37 (4). pp. 365-371. ISSN 0012-186X

Wagner, R., McNally, J. M., Bonifacio, E., Genovese, S., Foulis, A., McGill, M., Christie, M. R., Betterle, C., Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

Winnock, Frederic, Christie, Michael R., Batstra, Manou R., Aanstoot, Henk-Jan, Weets, Ilse, Decochez, Katelijn, Jopart, Philippe, Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

Zhao, M., Christie, M.R., Heaton, N., George, S., Amiel, S. and Huang, G.C. (2002) Amelioration of streptozotocin-induced diabetes in mice using human islet cells derived from long-term culture in vitro. Transplantation, 73 (9). pp. 1454-1460. ISSN 0041-1337

Islets of Langerhans Transplantation

Huang, Guo Cai, Zhao, Min, Jones, Peter, Persaud, Shanta, Ramracheya, Reshma, Lobner, Kristian, Christie, Michael R., Banga, J. Paul, Peakman, Mark, Sirinivsan, Parthi, Rela, Mohammed, Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Zhao, M., Christie, M.R., Heaton, N., George, S., Amiel, S. and Huang, G.C. (2002) Amelioration of streptozotocin-induced diabetes in mice using human islet cells derived from long-term culture in vitro. Transplantation, 73 (9). pp. 1454-1460. ISSN 0041-1337

Isoenzymes

Christie, M. R. (1993) Characterization of distinct islet protein auto antigens associated with type 1 diabetes. Autoimmunity, 15 (s1). pp. 1-3. ISSN 0891-6934

Christie, Michael, Brown, T. J. and Cassidy, D. (1992) Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme. Diabetologia, 35 (4). pp. 380-384. ISSN 0012-186X

Damanhouri, L. H., Dromey, J. A., Christie, Michael R., Nasrat, H. A., Ardawi, M. S. M., Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Gylling, Mikhail, Tuomi, Tiinamaija, Bjorses, Petra, Kontiainen, Sirkka, Partanen, Jukka, Christie, Michael R., Knip, Mikael, Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

J774

Moss, David W. and Bates, Timothy E. (2001) Activation of murine microglial cell lines by lipopolysaccharide and interferon-gamma causes NO-mediated decreases in mitochondrial and cellular function. The European Journal of Neuroscience, 13 (3). pp. 529-38. ISSN 0953-816X

JAK/STAT

Boasman, Kristian, Simmonds, Matthew and Rinaldi, Ciro (2018) CALR and CD47: An insight into their roles in the disease progression of MDS and MPN. Journal of Blood Disorders & Transfusion . ISSN 2155-9864

JCNotOpen

Long, Lu, Ormiston, Mark L., Yang, Xudong, Southwood, Mark, Gräf, Stefan, Machado, Rajiv D., Mueller, Matthias, Kinzel, Bernd, Yung, Lai Ming, Wilkinson, Janine M., Moore, Stephen D., Drake, Kylie M., Aldred, Micheala A., Yu, Paul B., Upton, Paul D. and Morrell, Nicholas W. (2015) Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension. Nature Medicine, 21 (7). pp. 777-785. ISSN 1078-8956

JCOpen

McLaughlin, Kerry A., Richardson, Carolyn C., Ravishankar, Aarthi, Brigatti, Cristina, Liberati, Daniela, Lampasona, Vito, Piemonti, Lorenzo, Morgan, Diana, Feltbower, Richard G. and Christie, Michael R. (2016) Identification of tetraspanin-7 as a target of autoantibodies in type 1 diabetes. Diabetes, 65 (6). pp. 1690-1698. ISSN 0012-1797

Richardson, Carolyn, McLaughlin, Kerry, Morgan, Diana, Feltbower, Richard and Christie, Michael (2016) Influence of HLA-DR and -DQ alleles on autoantibody recognition of distinct epitopes within the juxtamembrane domain of the IA-2 autoantigen in type 1 diabetes. Diabetologia, 59 (2). pp. 334-340. ISSN 0012-186X

Rodriguez, Alina (2016) Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. The Lancet, 388 (10053). pp. 1659-1724. ISSN 0140-6736

Keratinocytes

Eves, Paula, Bullet, Nial A., Haddow, David, Beck, Alison J., Layton, Christopher, Way, Louise, Shard, Alex G., Gawkrodger, David J. and MacNeil, Sheila (2008) Simplifying the delivery of melanocytes and keratinocytes for the treatment of vitiligo using a chemically defined carrier dressing. Journal of Investigative Dermatology, 128 (6). pp. 1554-1564. ISSN 0022-202X

MacNeil, Sheila and Eves, Paula (2006) Simplifying the delivery of cultured melanocytes and keratinocytes for grafting patients with vitiligo. In: Surgical management of vitiligo. Blackwell Publishing Ltd, pp. 191-202. ISBN 1405145218, 9781405145213

Kidney

Bates, T. E., Loesch, A., Burnstock, G. and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochemical and biophysical research communications, 218 (1). pp. 40-44. ISSN 0006-291X

Siamantouras, Eleftherios, Price, Gareth, Potter, Joe, Hills, Claire and Squires, Paul (2019) Purinergic receptor (P2X7) activation reduces cell–cell adhesion between tubular epithelial cells of the proximal kidney. Nanomedicine: Nanotechnology, Biology and Medicine, 22 . ISSN 1549-9634

Squires, Paul, Siamantouras, Eleftherios, Potter, Joe, Price, Gareth and Hills, Claire (2019) ATP reduces functional cell-to-cell tethering between renal tubular epithelial cells. In: Physiology 2019 (The Physiological Society), 08/07/19-to-10/07/19, Aberdeen.

L-buthionine sulfoximine

Heales, S. J., Davies, S. E., Bates, T. E. and Clark, J. B. (1995) Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration. Neurochemical research, 20 (1). pp. 31-38. ISSN 0364-3190

LASCA

Tew, Garry A., Klonizakis, Markos, Crank, Helen, Briers, J. David and Hodges, Gary J. (2011) Comparison of laser speckle contrast imaging with laser Doppler for assessing microvascular function. Microvascular Research, 82 (3). pp. 326-332. ISSN 0026-2862

LDF

Tew, G., Klonizakis, Markos, Moss, J., Ruddock, A. D., Saxton, J. M. and Hodges, G. J. (2011) Role of sensory nerves in the rapid cutaneous vasodilator response to local heating in young and older endurance-trained and untrained men. Experimental Physiology, 96 (2). pp. 163-170. ISSN 0958-0670

LPS

Moss, David W. and Bates, Timothy E. (2001) Activation of murine microglial cell lines by lipopolysaccharide and interferon-gamma causes NO-mediated decreases in mitochondrial and cellular function. The European Journal of Neuroscience, 13 (3). pp. 529-38. ISSN 0953-816X

Laser Doppler flowmetry

Tew, G., Klonizakis, Markos, Moss, J., Ruddock, A. D., Saxton, J. M. and Hodges, G. J. (2011) Reproducibility of cutaneous thermal hyperaemia assessed by laser Doppler flowmetry in young and older adults. Microvascular Research, 81 (2). pp. 177-182. ISSN 0026-2862

Tew, G., Klonizakis, Markos, Moss, J., Ruddock, A., Saxton, J. M. and Hodges, G. (2010) Role of sensory nerves in the rapid cutaneous vasodilator response to local heating in young and older endurance-trained and untrained men. In: 9th World Congress on Microcirculation, 26 - 28 September 2010, Maison de la Chimie, Paris.

Tew, G., Klonizakis, Markos and Saxton, G. (2010) Effects of ageing and fitness on skin-microvessel vasodilator function in humans. European Journal of Applied Physiology, 109 (2). pp. 173-181. ISSN 1439-6319

Laser Doppler fluximetry

Klonizakis, Markos, Manning, Gillian and Donnelly, Richard (2011) Assessment of lower limb microcirculation: exploring the reproducibility and clinical application of laser doppler techniques. Skin Pharmacology and Physiology: Journal of Pharmacological and Biophysical Research, 24 (3). pp. 136-143. ISSN 1660-5527

Lectins

Payton, M. A., Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Life Tables

Bingley, P. J., Christie, M. R., Bonifacio, E., Bonfanti, R., Shattock, M., Fonte, M.-T., Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Christie, Michael R., Roll, Ursula, Payton, Mark A., Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Lipopolysaccharide

Moss, David W. and Bates, Timothy E. (2001) Activation of murine microglial cell lines by lipopolysaccharide and interferon-gamma causes NO-mediated decreases in mitochondrial and cellular function. The European Journal of Neuroscience, 13 (3). pp. 529-38. ISSN 0953-816X

Liver

Bates, T. E, Loesch, A., Burnstock, G. and Clark, J. B. (1995) Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver. Biochemical and biophysical research communications, 213 (3). pp. 896-900. ISSN 0006-291X

Dagnelie, P. C., Bell, J. D., Williams, S. C., Bates, T. E., Abel, P. D. and Foster, C. S. (1993) Altered phosphorylation status, phospholipid metabolism and gluconeogenesis in the host liver of rats with prostate cancer: a 31P magnetic resonance spectroscopy study. British Journal of Cancer, 67 (6). pp. 1303-1309. ISSN 0007-0920

Murphy, Elizabeth J., Bates, Timothy E., Williams, Stephen R., Watson, Tracey, Brindle, Kevin M., Rajagopalan, Bheeshma and Radda, George K. (1992) Endoplasmic reticulum: the major contributor to the PDE peak in hepatic 31P-NMR spectra at low magnetic field strengths. Biochimica et biophysica acta: biomembranes, 1111 (1). pp. 51-58. ISSN 0005-2736

Sammut, Ivan A., Thorniley, Maureen S., Simpkin, Sandra, Fuller, Barry J., Bates, Timothy E. and Green, Colin J. (1998) Impairment of hepatic mitochondrial respiratory function following storage and orthotopic transplantation of rat livers. Cryobiology, 36 (1). pp. 49-60. ISSN 0011-2240

MCAO

Canevari, Laura, Kuroda, Satoshi, Bates, Timothy E., Clark, John B. and Siesjö, Bo K. (1997) Activity of mitochondrial respiratory chain enzymes after transient focal ischemia in the rat. Journal of Cerebral Blood Flow and Metabolism : official Journal of the International Society of Cerebral Blood Flow and Metabolism, 17 (11). pp. 1166-9. ISSN 0271-678X

MOF

Chalati, Tamim, Horcajada, P., Gref, R., Couvreur, P. and Serre, C. (2011) Optimisation of the synthesis of MOF nanoparticles made of flexible porous iron fumarate MIL-88A. Journal of Material Chemistry, 21 (7). pp. 2220-2227. ISSN 10.1039/C0JM03563G

Horcajada, Patricia, Chalati, Tamim, Serre, Christian, Gillet, Brigitte, Sebrie, Catherine, Baati, Tarek, Eubank, Jarrod, Heurtaux, Daniela, Clayette, Pascal, Kreuz, Christine, Chang, Jong-San, Hwang, Young Kyu, Marsaud, Veronique, Bories, Phuong-Nhi, Cynober, Luc, Gil, Sophie, Ferey, Gerard, Couvreur, Patrick and Gref, Ruxandra (2010) Porous metal–organic-framework nanoscale carriers as a potential platform for drug delivery and imaging. Nature Materials, 9 . pp. 172-178. ISSN 1476-4660

MPN

Rinaldi, Ciro R., Rinaldi, Paola, Alagia, Adele, Gemei, Marica, Esposito, Nicola, Formiggini, Fabio, Martinelli, Vincenzo, Senyuk, Vitalyi, Nucifora, Giuseppina and Pane, Fabrizio (2010) Preferential nuclear accumulation of JAK2V617F in CD34+ but not in granulocytic, megakaryocytic, or erythroid cells of patients with Philadelphia-negative myeloproliferative neoplasia. Blood, 116 (26). pp. 6023-6026. ISSN 0006-4971

MPP+

Bates, T. E., Heales, S. J., Davies, S. E., Boakye, P. and Clark, J. B. (1994) Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. Journal of neurochemistry, 63 (2). pp. 640-648. ISSN 0022-3042

MPT Pore

Kristián, Tibor, Gertsch, Jeff, Bates, Timothy E. and Siesjö, Bo K. (2000) Characteristics of the calcium-triggered mitochondrial permeability transition in nonsynaptic brain mitochondria: effect of cyclosporin A and ubiquinone O. Journal of Neurochemistry, 74 (5). pp. 1999-2009. ISSN 0022-3042

MPTP

Bates, T. E., Heales, S. J., Davies, S. E., Boakye, P. and Clark, J. B. (1994) Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. Journal of neurochemistry, 63 (2). pp. 640-648. ISSN 0022-3042

MRCGP

Asghar, Zahid and Siriwardena, Niro (2018) Performance of candidates with dyslexia in the Applied Knowledge Test for membership of the Royal College of General Practitioners. In: SAPC ASM 2017 - Warwick 46th annual scientific meeting, 12 - 14 July 2017, Warwick.

MRS

Bates, Timothy E., Strangward, Maria, Keelan, Julia, Davey, Gavin P., Munro, Peter M. G. and Clark, John B. (1996) Inhibition of N-acetylaspartate production: implications for 1H MRS studies in vivo. Neuroreport, 7 (8). pp. 1397-1400. ISSN 0959-4965

Dagnelie, P. C., Bell, J. D., Williams, S. C., Bates, T. E., Abel, P. D. and Foster, C. S. (1993) Altered phosphorylation status, phospholipid metabolism and gluconeogenesis in the host liver of rats with prostate cancer: a 31P magnetic resonance spectroscopy study. British Journal of Cancer, 67 (6). pp. 1303-1309. ISSN 0007-0920

Dagnelie, Pieter C., Bell, Jimmy D., Williams, Steve C., Bates, Timothy E., Abel, Paul D. and Foster, Christopher S. (1994) Effect of fish oil on cancer cachexia and host liver metabolism in rats with prostate tumors. Lipids, 29 (3). pp. 195-203. ISSN 0024-4201

Male

Christie, M. R., Pipeleers, D. G., Lernmark, A. and Baekkeskov, S. (1990) Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes. Journal of Biological Chemistry, 265 (1). pp. 376-381. ISSN 0021-9258

Gorus, F. K., Goubert, P., Semakula, C., Vandewalle, C. L., De Schepper, J., Scheen, A., Christie, Michael R. and Pipeleers, D. G. (1997) IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia, 40 (1). pp. 95-99. ISSN 0012-186X

Hawkes, C. J., Schloot, N. C., Marks, J., Willemen, S. J. M., Drijfhout, J. W., Mayer, E. K., Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

Huang, Guo Cai, Zhao, Min, Jones, Peter, Persaud, Shanta, Ramracheya, Reshma, Lobner, Kristian, Christie, Michael R., Banga, J. Paul, Peakman, Mark, Sirinivsan, Parthi, Rela, Mohammed, Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Tremble, Jennifer, Morgenthaler, Nils G., Vlug, Arjen, Powers, Alvin C., Christie, Michael R., Scherbaum, Werner A. and Banga, J. Paul (1997) Human B cells secreting immunoglobulin G to glutamic acid decarboxylase- 65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes. Journal of Clinical Endocrinology and Metabolism, 82 (8). pp. 2664-2670. ISSN 0021-972X

Mass Screening

Christie, Michael R., Roll, Ursula, Payton, Mark A., Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Melanocytes

Eves, Paula, Bullet, Nial A., Haddow, David, Beck, Alison J., Layton, Christopher, Way, Louise, Shard, Alex G., Gawkrodger, David J. and MacNeil, Sheila (2008) Simplifying the delivery of melanocytes and keratinocytes for the treatment of vitiligo using a chemically defined carrier dressing. Journal of Investigative Dermatology, 128 (6). pp. 1554-1564. ISSN 0022-202X

Membrane Glycoproteins

Hatfield, E. C. I., Hawkes, C. J., Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Hawkes, C. J., Wasmeier, C., Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Hawkes, C. J., Schloot, N. C., Marks, J., Willemen, S. J. M., Drijfhout, J. W., Mayer, E. K., Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

Morgenthaler, N. G., Löbner, K., Morgenthaler, U. Y., Christie, M. R., Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Membrane Proteins

Bearzatto, Massimo, Naserke, Heike, Piquer, Sandra, Koczwara, Kerstin, Lampasona, Vito, Williams, Alistair, Christie, Michael R., Bingley, Polly J., Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Christie, Michael R., Roll, Ursula, Payton, Mark A., Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Hatfield, E. C. I., Hawkes, C. J., Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Hawa, M., Rowe, R., Lan, M. S., Notkins, A. L., Pozzilli, P., Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Hawkes, C. J., Wasmeier, C., Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Hawkes, C. J., Schloot, N. C., Marks, J., Willemen, S. J. M., Drijfhout, J. W., Mayer, E. K., Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

Morgenthaler, N. G., Löbner, K., Morgenthaler, U. Y., Christie, M. R., Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Morgenthaler, N. G., Seissler, J., Achenbach, P., Glawe, D., Payton, M., Meinck, H.-M., Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Payton, M. A., Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Piquer, Sandra, Valera, Lionel, Lampasona, Vito, Jardin-Watelet, Benedicte, Roche, Stephanie, Granier, Claude, Roquet, Francoise, Christie, Michael R., Giordano, Tiziana, Malosio, Maria-Luisa, Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

Mental health workers

Golightley, Malcolm and Goemans, Robert (2017) Social work and mental health. 6th Edition. Transforming Social Work Practice . Learning Matters. ISBN 9781473989290

Mice

Hasnain, Sumaira Z., Borg, Danielle J., Harcourt, Brooke E., Tong, Hui, Sheng, Yonhua H., Ng, Choa ping, Das, Indrajit, Wang, Ran, Chen, Alice C.-H., Loudovaris, Thomas, Kay, Thomas W., Thomas, Helen E., Whitehead, Jonathan P., Forbes, Josephine M., Prins, Johannes B. and McGuckin, Michael A. (2014) Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress. Nature Medicine, 20 (12). pp. 1417-1426. ISSN 1078-8956

Huang, Guo Cai, Zhao, Min, Jones, Peter, Persaud, Shanta, Ramracheya, Reshma, Lobner, Kristian, Christie, Michael R., Banga, J. Paul, Peakman, Mark, Sirinivsan, Parthi, Rela, Mohammed, Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Piquer, Sandra, Valera, Lionel, Lampasona, Vito, Jardin-Watelet, Benedicte, Roche, Stephanie, Granier, Claude, Roquet, Francoise, Christie, Michael R., Giordano, Tiziana, Malosio, Maria-Luisa, Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

Roll, U., Christie, M. R., Fuchtenbusch, M., Payton, M. A., Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Zhao, M., Christie, M.R., Heaton, N., George, S., Amiel, S. and Huang, G.C. (2002) Amelioration of streptozotocin-induced diabetes in mice using human islet cells derived from long-term culture in vitro. Transplantation, 73 (9). pp. 1454-1460. ISSN 0041-1337

Zhao, M., Amiel, S. A., Christie, Michael R., Rela, M., Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Mice, Inbred BALB C

Piquer, Sandra, Valera, Lionel, Lampasona, Vito, Jardin-Watelet, Benedicte, Roche, Stephanie, Granier, Claude, Roquet, Francoise, Christie, Michael R., Giordano, Tiziana, Malosio, Maria-Luisa, Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

Mice, Inbred NOD

Roll, U., Christie, M. R., Fuchtenbusch, M., Payton, M. A., Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Mice, SCID

Huang, Guo Cai, Zhao, Min, Jones, Peter, Persaud, Shanta, Ramracheya, Reshma, Lobner, Kristian, Christie, Michael R., Banga, J. Paul, Peakman, Mark, Sirinivsan, Parthi, Rela, Mohammed, Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Zhao, M., Christie, M.R., Heaton, N., George, S., Amiel, S. and Huang, G.C. (2002) Amelioration of streptozotocin-induced diabetes in mice using human islet cells derived from long-term culture in vitro. Transplantation, 73 (9). pp. 1454-1460. ISSN 0041-1337

Zhao, M., Amiel, S. A., Christie, Michael R., Rela, M., Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Microbial Collagenase

Hansen, W.A., Christie, M.R., Kahn, R., Norgaard, A., Abel, I., Petersen, A.M., Jorgensen, D.W., Baekkeskov, S., Nielsen, J.H., Lernmark, A., Egeberg, J., Richter-Olesen, H., Grainger, T., Kristensen, J.K., Brynitz, S. and Bilde, T. (1989) Supravital dithizone staining in the isolation of human and rat pancreatic islets. Diabetes Research, 10 (2). pp. 53-57. ISSN 0265-5985

Microvascular perfusion

Klonizakis, Markos, Manning, Gillian and Donnelly, Richard (2011) Assessment of lower limb microcirculation: exploring the reproducibility and clinical application of laser doppler techniques. Skin Pharmacology and Physiology: Journal of Pharmacological and Biophysical Research, 24 (3). pp. 136-143. ISSN 1660-5527

Middle Age

Christie, M. R., Genovese, S., Cassidy, D., Bosi, E., Brown, T. J., Lai, M., Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

Christie, Michael, Brown, T. J. and Cassidy, D. (1992) Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme. Diabetologia, 35 (4). pp. 380-384. ISSN 0012-186X

Roll, U., Christie, M. R., Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

Wagner, R., Genovese, S., Bosi, E., Becker, F., Bingley, P. J., Bonifacio, E., Miles, K. A., Christie, Michael, Bottazzo, G. F. and Gale, E. A. M. (1994) Slow metabolic deterioration towards diabetes in islet cell antibody positive patients with autoimmune polyendocrine disease. Diabetologia, 37 (4). pp. 365-371. ISSN 0012-186X

Middle Aged

Bingley, P. J., Christie, M. R., Bonifacio, E., Bonfanti, R., Shattock, M., Fonte, M.-T., Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Damanhouri, L. H., Dromey, J. A., Christie, Michael R., Nasrat, H. A., Ardawi, M. S. M., Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Desai, M.a, Cull, C.A.b, Horton, V.A.a, Christie, M.R.c, Bonifacio, E.d, Lampasona, V.d, Bingley, P.J.e, Levy, J.C.a, Mackay, I.R.f, Zimmet, P.g, Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Hawa, M., Rowe, R., Lan, M. S., Notkins, A. L., Pozzilli, P., Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Huang, Guo Cai, Zhao, Min, Jones, Peter, Persaud, Shanta, Ramracheya, Reshma, Lobner, Kristian, Christie, Michael R., Banga, J. Paul, Peakman, Mark, Sirinivsan, Parthi, Rela, Mohammed, Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Lampeter, E. F., Kolb, H., Seifert, I., Lohmann, D., Heise, J. W., Bertrams, J., Christie, Michael and Kolb-Bachofen, V. (1994) Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity. Diabetologia, 37 (5). pp. 471-475. ISSN 0012-186X

Morgenthaler, N. G., Löbner, K., Morgenthaler, U. Y., Christie, M. R., Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Morgenthaler, N. G., Seissler, J., Achenbach, P., Glawe, D., Payton, M., Meinck, H.-M., Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Wagner, R., McNally, J. M., Bonifacio, E., Genovese, S., Foulis, A., McGill, M., Christie, M. R., Betterle, C., Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

Zhao, M., Amiel, S. A., Christie, Michael R., Rela, M., Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Miller-Fisher Syndrome or Chronic Inflammatory Demyelinating Polyneuropathy

Curtis, Ffion, Laparidou, Despina, Akanuwe, N.A Joseph, Ellis-Vowles, Victoria, Jackson, Jennifer, Senevirathna, Mahendra, Menezes, Igor, Hodgson, Timothy and Siriwardena, A. Niroshan (2019) Patient experiences and perceptions of Guillain-Barré Syndrome and associated inflammatory neuropathies following discharge from hospital. PROSPERO: International prospective register of systematic reviews .

Mitochondria

Allen, Kathryn L., Almeida, Angeles, Bates, Timothy E. and Clark, John B. (1995) Changes of respiratory chain activity in mitochondrial and synaptosomal fractions isolated from the gerbil brain after graded ischaemia. Journal of neurochemistry, 64 (5). pp. 2222-2229. ISSN 0022-3042

Almeida, A., Brooks, K. J., Sammut, I., Keelan, J., Davey, G. P., Clark, J. B. and Bates, T. E. (1995) Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain. Developmental neuroscience, 17 (4). pp. 212-218. ISSN 0378-5866

Almeida, Angeles, Allen, Kathryn L., Bates, TImothy E. and Clark, John B. (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. Journal of neurochemistry, 65 (4). pp. 1698-1703. ISSN 0022-3042

Bates, T. E, Loesch, A., Burnstock, G. and Clark, J. B. (1995) Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver. Biochemical and biophysical research communications, 213 (3). pp. 896-900. ISSN 0006-291X

Bates, T. E., Heales, S. J., Davies, S. E., Boakye, P. and Clark, J. B. (1994) Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. Journal of neurochemistry, 63 (2). pp. 640-648. ISSN 0022-3042

Bates, Timothy E., Strangward, Maria, Keelan, Julia, Davey, Gavin P., Munro, Peter M. G. and Clark, John B. (1996) Inhibition of N-acetylaspartate production: implications for 1H MRS studies in vivo. Neuroreport, 7 (8). pp. 1397-1400. ISSN 0959-4965

Brooks, Keith J., Hargreaves, Iain P. and Bates, Timothy E. (2008) Protection of respiratory chain enzymes from ischaemic damage in adult rat brain slices. Neurochemical research, 33 (9). pp. 1711-1716. ISSN 0364-3190

Canevari, Laura, Clark, John B. and Bates, Timothy E. (1999) Beta-amyloid fragment 25-35 selectively decreases complex IV activity in isolated mitochondria. FEBS Letters, 457 (1). pp. 131-4. ISSN 0014-5793

Heales, S. J., Davies, S. E., Bates, T. E. and Clark, J. B. (1995) Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration. Neurochemical research, 20 (1). pp. 31-38. ISSN 0364-3190

Sammut, Ivan A., Thorniley, Maureen S., Simpkin, Sandra, Fuller, Barry J., Bates, Timothy E. and Green, Colin J. (1998) Impairment of hepatic mitochondrial respiratory function following storage and orthotopic transplantation of rat livers. Cryobiology, 36 (1). pp. 49-60. ISSN 0011-2240

Mitochondrial complexes

Canevari, Laura, Kuroda, Satoshi, Bates, Timothy E., Clark, John B. and Siesjö, Bo K. (1997) Activity of mitochondrial respiratory chain enzymes after transient focal ischemia in the rat. Journal of Cerebral Blood Flow and Metabolism : official Journal of the International Society of Cerebral Blood Flow and Metabolism, 17 (11). pp. 1166-9. ISSN 0271-678X

Sammut, Ivan A., Thorniley, Maureen S., Simpkin, Sandra, Fuller, Barry J., Bates, Timothy E. and Green, Colin J. (1998) Impairment of hepatic mitochondrial respiratory function following storage and orthotopic transplantation of rat livers. Cryobiology, 36 (1). pp. 49-60. ISSN 0011-2240

Models

Eves, Paula, Bullet, Nial A., Haddow, David, Beck, Alison J., Layton, Christopher, Way, Louise, Shard, Alex G., Gawkrodger, David J. and MacNeil, Sheila (2008) Simplifying the delivery of melanocytes and keratinocytes for the treatment of vitiligo using a chemically defined carrier dressing. Journal of Investigative Dermatology, 128 (6). pp. 1554-1564. ISSN 0022-202X

Molecular Sequence Data

Payton, M. A., Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Piquer, Sandra, Valera, Lionel, Lampasona, Vito, Jardin-Watelet, Benedicte, Roche, Stephanie, Granier, Claude, Roquet, Francoise, Christie, Michael R., Giordano, Tiziana, Malosio, Maria-Luisa, Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

Molecular Weight

Baekkeskov, S., Warnock, G., Christie, M., Rajotte, R.V., Larsen, P.M. and Fey, S. (1989) Revelation of specificity of 64K autoantibodies in IDDM serums by high-resolution 2-D gel electrophoresis. Unambiguous identification of 64K target antigen. Diabetes, 38 (9). pp. 1133-1141. ISSN 0012-1797

Christie, M. R., Pipeleers, D. G., Lernmark, A. and Baekkeskov, S. (1990) Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes. Journal of Biological Chemistry, 265 (1). pp. 376-381. ISSN 0021-9258

Christie, M. R., Tun, R. Y. M., Lo, S. S. S., Cassidy, D., Brown, T. J., Hollands, J., Shattock, M., Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Christie, M. R., Vohra, G., Champagne, P., Daneman, D. and Delovitch, T. L. (1990) Distinct antibody specificities to a 64-kD islet cell antigen in Type 1 diabetes as revealed by trypsin treatment. Journal of Experimental Medicine, 172 (3). pp. 789-794. ISSN 0022-1007

Christie, M. R., Hollands, J. A., Brown, T. J., Michelsen, B. K. and Delovitch, T. L. (1993) Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. Journal of Clinical Investigation, 92 (1). pp. 240-248. ISSN 0021-9738

Hawkes, C. J., Wasmeier, C., Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Payton, M. A., Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Monolayer integrity

Long, Lu, Ormiston, Mark L., Yang, Xudong, Southwood, Mark, Gräf, Stefan, Machado, Rajiv D., Mueller, Matthias, Kinzel, Bernd, Yung, Lai Ming, Wilkinson, Janine M., Moore, Stephen D., Drake, Kylie M., Aldred, Micheala A., Yu, Paul B., Upton, Paul D. and Morrell, Nicholas W. (2015) Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension. Nature Medicine, 21 (7). pp. 777-785. ISSN 1078-8956

Mothers

Roll, U., Christie, M. R., Fuchtenbusch, M., Payton, M. A., Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Mucositis

Colley, Helen E., Eves, Paula, Pinnock, Abigail, Thornhill, Martin H. and Murdoch, Craig (2013) Tissue-engineered oral mucosa to study radiotherapy-induced oral mucositis. International Journal of Radiation Biology, 89 (11). pp. 907-914. ISSN 0955-3002

Mutation

Hatfield, E. C. I., Hawkes, C. J., Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

N omega-nitro-L-arginine

Brooks, Keith J., Hargreaves, Iain P. and Bates, Timothy E. (2008) Protection of respiratory chain enzymes from ischaemic damage in adult rat brain slices. Neurochemical research, 33 (9). pp. 1711-1716. ISSN 0364-3190

N-Acetylaspartate

Brooks, Keith J, Hargreaves, Iain, Bhakoo, Kishore, Sellwood, Mark, O'Brien, Francis, Noone, Martina, Sakata, Yasuko, Cady, Ernest, Wylezinska, Marzena, Thornton, John, Ordidge, Roger, Nguyen, Quyen, Clemence, Matthew, Wyatt, John and Bates, Timothy E. (2002) Delayed hypothermia prevents decreases in N-acetylaspartate and reduced glutathione in the cerebral cortex of the neonatal pig following transient hypoxia-ischaemia. Neurochemical Research, 27 (12). pp. 1599-604. ISSN 0364-3190

N-acetylaspartate

Bates, Timothy E., Strangward, Maria, Keelan, Julia, Davey, Gavin P., Munro, Peter M. G. and Clark, John B. (1996) Inhibition of N-acetylaspartate production: implications for 1H MRS studies in vivo. Neuroreport, 7 (8). pp. 1397-1400. ISSN 0959-4965

N11

Moss, David W. and Bates, Timothy E. (2001) Activation of murine microglial cell lines by lipopolysaccharide and interferon-gamma causes NO-mediated decreases in mitochondrial and cellular function. The European Journal of Neuroscience, 13 (3). pp. 529-38. ISSN 0953-816X

NAA

Brooks, Keith J, Hargreaves, Iain, Bhakoo, Kishore, Sellwood, Mark, O'Brien, Francis, Noone, Martina, Sakata, Yasuko, Cady, Ernest, Wylezinska, Marzena, Thornton, John, Ordidge, Roger, Nguyen, Quyen, Clemence, Matthew, Wyatt, John and Bates, Timothy E. (2002) Delayed hypothermia prevents decreases in N-acetylaspartate and reduced glutathione in the cerebral cortex of the neonatal pig following transient hypoxia-ischaemia. Neurochemical Research, 27 (12). pp. 1599-604. ISSN 0364-3190

NMR

Murphy, Elizabeth J., Bates, Timothy E., Williams, Stephen R., Watson, Tracey, Brindle, Kevin M., Rajagopalan, Bheeshma and Radda, George K. (1992) Endoplasmic reticulum: the major contributor to the PDE peak in hepatic 31P-NMR spectra at low magnetic field strengths. Biochimica et biophysica acta: biomembranes, 1111 (1). pp. 51-58. ISSN 0005-2736

NMR Spectroscopy

Bakken, Inger J., Sonnewald, Ursula, Clark, John B. and Bates, Timothy E. (1997) [U-13C]glutamate metabolism in rat brain mitochondria reveals malic enzyme activity. Neuroreport, 8 (7). pp. 1567-1570. ISSN 0959-4965

Brooks, K. J., Clark, J. B. and Bates, T. E. (1996) Assessment of energy metabolism in the developing brain following aglycemic hypoxia by 1H and 31P NMR. Neurochemical Research, 21 (9). pp. 1089-1095. ISSN 0364-3190

Gadian, D. G., Williams, S. R., Bates, T. E. and Kauppinen, R. A. (1993) NMR spectroscopy: current status and future possibilities. Acta neurochirurgica. Supplementum, 57 . pp. 1-8. ISSN 0065-1419

NMR spectroscopy

Dagnelie, P. C., Bell, J. D., Williams, S. C., Bates, T. E., Abel, P. D. and Foster, C. S. (1993) Altered phosphorylation status, phospholipid metabolism and gluconeogenesis in the host liver of rats with prostate cancer: a 31P magnetic resonance spectroscopy study. British Journal of Cancer, 67 (6). pp. 1303-1309. ISSN 0007-0920

Dagnelie, Pieter C., Bell, Jimmy D., Williams, Steve C., Bates, Timothy E., Abel, Paul D. and Foster, Christopher S. (1994) Effect of fish oil on cancer cachexia and host liver metabolism in rats with prostate tumors. Lipids, 29 (3). pp. 195-203. ISSN 0024-4201

NO

Calabrese, V., Bates, T. E. and Stella, A. M. (2000) NO synthase and NO-dependent signal pathways in brain aging and neurodegenerative disorders: the role of oxidant/antioxidant balance. Neurochemical Research, 25 (9-10). pp. 1315-41. ISSN 0364-3190

Calabrese, Vittorio, Scapagnini, Giovanni, Ravagna, Agrippino, Bella, Rita, Foresti, Roberta, Bates, Timothy E., Giuffrida Stella, Anna-Maria and Pennisi, Giovanni (2002) Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels. Journal of Neuroscience Research, 70 (4). pp. 580-7. ISSN 0360-4012

Cooper, Chris E., Davies, Nathan A., Psychoulis, Minas, Canevari, Laura, Bates, Tim E., Dobbie, Michael S., Casley, Christopher S. and Sharpe, Martyn A. (2003) Nitric oxide and peroxynitrite cause irreversible increases in the K(m) for oxygen of mitochondrial cytochrome oxidase: in vitro and in vivo studies. Biochimica et Biophysica Acta: general subjects, 1607 (1). pp. 27-34. ISSN 0006-3002

Keelan, J., Brand, M. P., Bates, T. E., Land, J. M., Clark, J. B. and Heales, S. J. (1996) Nitric oxide and antioxidant status in glucose and oxygen deprived neonatal and adult rat brain synaptosomes. Neurochemical Research, 21 (8). pp. 923-7. ISSN 0364-3190

Moss, David W. and Bates, Timothy E. (2001) Activation of murine microglial cell lines by lipopolysaccharide and interferon-gamma causes NO-mediated decreases in mitochondrial and cellular function. The European Journal of Neuroscience, 13 (3). pp. 529-38. ISSN 0953-816X

NOS

Bates, T. E, Loesch, A., Burnstock, G. and Clark, J. B. (1995) Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver. Biochemical and biophysical research communications, 213 (3). pp. 896-900. ISSN 0006-291X

Bates, T. E., Loesch, A., Burnstock, G. and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochemical and biophysical research communications, 218 (1). pp. 40-44. ISSN 0006-291X

Calabrese, V., Bates, T. E. and Stella, A. M. (2000) NO synthase and NO-dependent signal pathways in brain aging and neurodegenerative disorders: the role of oxidant/antioxidant balance. Neurochemical Research, 25 (9-10). pp. 1315-41. ISSN 0364-3190

Calabrese, Vittorio, Scapagnini, Giovanni, Ravagna, Agrippino, Bella, Rita, Foresti, Roberta, Bates, Timothy E., Giuffrida Stella, Anna-Maria and Pennisi, Giovanni (2002) Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels. Journal of Neuroscience Research, 70 (4). pp. 580-7. ISSN 0360-4012

Moss, David W. and Bates, Timothy E. (2001) Activation of murine microglial cell lines by lipopolysaccharide and interferon-gamma causes NO-mediated decreases in mitochondrial and cellular function. The European Journal of Neuroscience, 13 (3). pp. 529-38. ISSN 0953-816X

Nanoparticles

Chalati, Tamim, Horcajada, P., Gref, R., Couvreur, P. and Serre, C. (2011) Optimisation of the synthesis of MOF nanoparticles made of flexible porous iron fumarate MIL-88A. Journal of Material Chemistry, 21 (7). pp. 2220-2227. ISSN 10.1039/C0JM03563G

Horcajada, Patricia, Chalati, Tamim, Serre, Christian, Gillet, Brigitte, Sebrie, Catherine, Baati, Tarek, Eubank, Jarrod, Heurtaux, Daniela, Clayette, Pascal, Kreuz, Christine, Chang, Jong-San, Hwang, Young Kyu, Marsaud, Veronique, Bories, Phuong-Nhi, Cynober, Luc, Gil, Sophie, Ferey, Gerard, Couvreur, Patrick and Gref, Ruxandra (2010) Porous metal–organic-framework nanoscale carriers as a potential platform for drug delivery and imaging. Nature Materials, 9 . pp. 172-178. ISSN 1476-4660

Neoplasm Proteins

Hatfield, E. C. I., Hawkes, C. J., Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Hawkes, C. J., Wasmeier, C., Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Nerve Tissue Proteins

Christie, M. R. (1993) Characterization of distinct islet protein auto antigens associated with type 1 diabetes. Autoimmunity, 15 (s1). pp. 1-3. ISSN 0891-6934

Nitric Oxide Synthase

Bates, T. E, Loesch, A., Burnstock, G. and Clark, J. B. (1995) Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver. Biochemical and biophysical research communications, 213 (3). pp. 896-900. ISSN 0006-291X

Bates, T. E., Loesch, A., Burnstock, G. and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochemical and biophysical research communications, 218 (1). pp. 40-44. ISSN 0006-291X

Brooks, K. J., Hargreaves, I. P. and Bates, T. E. (2000) Nitric-oxide-induced inhibition of mitochondrial complexes following aglycaemic hypoxia in neonatal cortical rat brain slices. Developmental Neuroscience, 22 (5-6). pp. 359-65. ISSN 0378-5866

Calabrese, V., Bates, T. E. and Stella, A. M. (2000) NO synthase and NO-dependent signal pathways in brain aging and neurodegenerative disorders: the role of oxidant/antioxidant balance. Neurochemical Research, 25 (9-10). pp. 1315-41. ISSN 0364-3190

Nitric oxide

Calabrese, Vittorio, Scapagnini, Giovanni, Ravagna, Agrippino, Bella, Rita, Foresti, Roberta, Bates, Timothy E., Giuffrida Stella, Anna-Maria and Pennisi, Giovanni (2002) Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels. Journal of Neuroscience Research, 70 (4). pp. 580-7. ISSN 0360-4012

Cooper, Chris E., Davies, Nathan A., Psychoulis, Minas, Canevari, Laura, Bates, Tim E., Dobbie, Michael S., Casley, Christopher S. and Sharpe, Martyn A. (2003) Nitric oxide and peroxynitrite cause irreversible increases in the K(m) for oxygen of mitochondrial cytochrome oxidase: in vitro and in vivo studies. Biochimica et Biophysica Acta: general subjects, 1607 (1). pp. 27-34. ISSN 0006-3002

Nitric oxide synthase

Calabrese, Vittorio, Scapagnini, Giovanni, Ravagna, Agrippino, Bella, Rita, Foresti, Roberta, Bates, Timothy E., Giuffrida Stella, Anna-Maria and Pennisi, Giovanni (2002) Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels. Journal of Neuroscience Research, 70 (4). pp. 580-7. ISSN 0360-4012

NotOAChecked

Catani, Mara, Walther, Denise, Christie, Michael, McLaughlin, Kerry, Bonifacio, Ezio and Eugster, Anne (2015) Isolation of human monoclonal autoantibodies derived from pancreatic lymph node and peripheral blood B cells of islet autoantibody-positive patients. Diabetologia . ISSN 0012-186X

D'Amore, Valerio, von Randow, Constanze, Nicoletti, Ferdinando, Ngomba, Richard and van Luijtelaar, Gilles (2015) Anti-absence activity of mGlu1 and mGlu5 receptor enhancers and their interaction with a GABA reuptake inhibitor: effect of local infusions in the somatosensory cortex and thalamus. Epilepsia, 56 (7). pp. 1141-51. ISSN 0013-9580

McLaughlin, Kerry A., Richardson, Carolyn C., Williams, Stefan, Bonifacio, Ezio, Morgan, Diana, Feltbower, Richard G., Powell, Michael, Rees Smith, Bernard, Furmaniak, Jadwiga and Christie, Michael R. (2015) Relationships between major epitopes of the IA-2 autoantigen in Type 1 diabetes: implications for determinant spreading. Clinical Immunology, 160 (2). pp. 226-236. ISSN 1521-6616

Middleton, Geoff, Keegan, Richard, Smith, Mark F., Alkhatib, Ahmed and Klonizakis, Markos (2015) Implementing a Mediterranean diet intervention into a RCT: lessons learned from a non-Mediterranean based country. Journal of Nutrition, Health and Aging, 19 (10). pp. 1019-1022. ISSN 1279-7707

Tchekalarova, Jana, Moyanova, Slavianka, Fusco, Antonio De and Ngomba, Richard Teke (2015) The role of the melatoninergic system in epilepsy and comorbid psychiatric disorders. Brain Research Bulletin, 119 (A). pp. 80-92. ISSN 0361-9230

Nuclear Family

Christie, Michael R., Roll, Ursula, Payton, Mark A., Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Gorus, F. K., Goubert, P., Semakula, C., Vandewalle, C. L., De Schepper, J., Scheen, A., Christie, Michael R. and Pipeleers, D. G. (1997) IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia, 40 (1). pp. 95-99. ISSN 0012-186X

Hawkes, C. J., Wasmeier, C., Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Roll, U., Christie, M. R., Fuchtenbusch, M., Payton, M. A., Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Roll, U., Christie, M. R., Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

O-phthalaldehyde

Al-Haj Sakur, Amir, Chalati, Tamim and Fael, Hanan (2015) Selective Spectrofluorimetric Method for the Determination of Perindopril Erbumine in Bulk and Tablets through Derivatization with O-Phthalaldehyde in Presence of 3-Mercaptopropionic Acid. International Journal of Academic Scientific Research, 3 (2). pp. 26-37. ISSN 2272-6446

Oral Cancer

Colley, Helen E., Eves, Paula, Pinnock, Abigail, Thornhill, Martin H. and Murdoch, Craig (2013) Tissue-engineered oral mucosa to study radiotherapy-induced oral mucositis. International Journal of Radiation Biology, 89 (11). pp. 907-914. ISSN 0955-3002

Organ Preservation Solutions

Huang, Guo Cai, Zhao, Min, Jones, Peter, Persaud, Shanta, Ramracheya, Reshma, Lobner, Kristian, Christie, Michael R., Banga, J. Paul, Peakman, Mark, Sirinivsan, Parthi, Rela, Mohammed, Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Organ Specificity

Christie, M. R. (1993) Characterization of distinct islet protein auto antigens associated with type 1 diabetes. Autoimmunity, 15 (s1). pp. 1-3. ISSN 0891-6934

Morgenthaler, N. G., Seissler, J., Achenbach, P., Glawe, D., Payton, M., Meinck, H.-M., Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Osmolar Concentration

Christie, M. R., Daneman, D., Champagne, P. and Delovitch, T. L. (1990) Persistence of serum antibodies to 64,000-Mr islet cell protein after onset of type I diabetes. Diabetes, 39 (6). pp. 653-656. ISSN 0012-1797

Ovarian Neoplasms

Wagner, R., McNally, J. M., Bonifacio, E., Genovese, S., Foulis, A., McGill, M., Christie, M. R., Betterle, C., Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

Oxidative Phosphorylation

Bates, T. E, Loesch, A., Burnstock, G. and Clark, J. B. (1995) Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver. Biochemical and biophysical research communications, 213 (3). pp. 896-900. ISSN 0006-291X

Oxidative Stress

Heales, S. J., Davies, S. E., Bates, T. E. and Clark, J. B. (1995) Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration. Neurochemical research, 20 (1). pp. 31-38. ISSN 0364-3190

Oxidative phsphorylation

Bates, Timothy E., Strangward, Maria, Keelan, Julia, Davey, Gavin P., Munro, Peter M. G. and Clark, John B. (1996) Inhibition of N-acetylaspartate production: implications for 1H MRS studies in vivo. Neuroreport, 7 (8). pp. 1397-1400. ISSN 0959-4965

Oxidative stress

Calabrese, V., Scapagnini, G., Catalano, C., Bates, T. E., Dinotta, F., Micali, G. and Giuffrida Stella, A. M. (2001) Induction of heat shock protein synthesis in human skin fibroblasts in response to oxidative stress: regulation by a natural antioxidant from rosemary extract. International Journal of Tissue Reactions, 23 (2). pp. 51-8. ISSN 0250-0868

P2X7

Siamantouras, Eleftherios, Price, Gareth, Potter, Joe, Hills, Claire and Squires, Paul (2019) Purinergic receptor (P2X7) activation reduces cell–cell adhesion between tubular epithelial cells of the proximal kidney. Nanomedicine: Nanotechnology, Biology and Medicine, 22 . ISSN 1549-9634

PBN

Kuroda, Satoshi, Katsura, Ken-ichiro, Hillered, Lars, Bates, Timothy E. and Siesjö, Bo K. (1996) Delayed treatment with alpha-phenyl-N-tert-butyl nitrone (PBN) attenuates secondary mitochondrial dysfunction after transient focal cerebral ischemia in the rat. Neurobiology of Disease, 3 (2). pp. 149-157. ISSN 0969-9961

Pancreas

Zhao, M., Amiel, S. A., Christie, Michael R., Rela, M., Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Pancreas Transplantation

Zhao, M., Amiel, S. A., Christie, Michael R., Rela, M., Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Pancreatic Neoplasms

Hawkes, C. J., Wasmeier, C., Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Parkinson's disease

Rosin, Claudia, Colombo, Sergio, Calver, Andrew A., Bates, Timothy E. and Skaper, Stephen D. (2005) Dopamine D2 and D3 receptor agonists limit oligodendrocyte injury caused by glutamate oxidative stress and oxygen/glucose deprivation. Glia, 52 (4). pp. 336-343. ISSN 0894-1491

Patient experiences

Akanuwe, Joseph, Asghar, Zahid, Laparidou, Despina, Curtis, Ffion, Jackson, Jennifer, Hodgson, Timothy and Siriwardena, Niro (2020) Experiences of people following Guillain-Barre Syndrome and Associated Neuropathies: questionnaire development and validation. In: SAPC ASM.

Akanuwe, Joseph, Laparidou, Despina, Curtis, Ffion, Jackson, Jennifer, Hodgson, Timothy and Siriwardena, Niro (2020) Exploring the experiences of people living with Guillain-Barré Syndrome and its variants: a qualitative interview study. In: SAPC 2020 ASM.

Laparidou, Despina, Curtis, Ffion, Akanuwe, Joseph, Jackson, Jennifer, Hodgson, Timothy and Siriwardena, Niro (2020) Patients’ experiences and perceptions of Guillain-Barré syndrome: a systematic review and meta-synthesis of qualitative research. In: SAPC ASM.

Peptide Fragments

Bearzatto, Massimo, Naserke, Heike, Piquer, Sandra, Koczwara, Kerstin, Lampasona, Vito, Williams, Alistair, Christie, Michael R., Bingley, Polly J., Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Christie, M. R., Tun, R. Y. M., Lo, S. S. S., Cassidy, D., Brown, T. J., Hollands, J., Shattock, M., Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Christie, M. R., Hollands, J. A., Brown, T. J., Michelsen, B. K. and Delovitch, T. L. (1993) Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. Journal of Clinical Investigation, 92 (1). pp. 240-248. ISSN 0021-9738

Desai, M.a, Cull, C.A.b, Horton, V.A.a, Christie, M.R.c, Bonifacio, E.d, Lampasona, V.d, Bingley, P.J.e, Levy, J.C.a, Mackay, I.R.f, Zimmet, P.g, Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Hatfield, E. C. I., Hawkes, C. J., Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Hawkes, C. J., Schloot, N. C., Marks, J., Willemen, S. J. M., Drijfhout, J. W., Mayer, E. K., Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

Payton, M. A., Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Peptide Mapping

Christie, M. R., Vohra, G., Champagne, P., Daneman, D. and Delovitch, T. L. (1990) Distinct antibody specificities to a 64-kD islet cell antigen in Type 1 diabetes as revealed by trypsin treatment. Journal of Experimental Medicine, 172 (3). pp. 789-794. ISSN 0022-1007

Peptides

Tremble, Jennifer, Morgenthaler, Nils G., Vlug, Arjen, Powers, Alvin C., Christie, Michael R., Scherbaum, Werner A. and Banga, J. Paul (1997) Human B cells secreting immunoglobulin G to glutamic acid decarboxylase- 65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes. Journal of Clinical Endocrinology and Metabolism, 82 (8). pp. 2664-2670. ISSN 0021-972X

Perindopril erbumine

Al-Haj Sakur, Amir, Chalati, Tamim and Fael, Hanan (2015) Selective Spectrofluorimetric Method for the Determination of Perindopril Erbumine in Bulk and Tablets through Derivatization with O-Phthalaldehyde in Presence of 3-Mercaptopropionic Acid. International Journal of Academic Scientific Research, 3 (2). pp. 26-37. ISSN 2272-6446

Perindopril erbumine; Dansyl chloride; Derivatization; Spectrofluorimetry

Sakur, Amir, Chalati, Tamim and Fael, Hanan (2015) Selective spectrofluorimetric method for the determination of perindopril erbumine in bulk and tablets through derivatization with dansyl chloride. Journal of Analytical Science and Technology, 6 (1). p. 12. ISSN 015-0045-6

Phosphodiester

Murphy, Elizabeth J., Bates, Timothy E., Williams, Stephen R., Watson, Tracey, Brindle, Kevin M., Rajagopalan, Bheeshma and Radda, George K. (1992) Endoplasmic reticulum: the major contributor to the PDE peak in hepatic 31P-NMR spectra at low magnetic field strengths. Biochimica et biophysica acta: biomembranes, 1111 (1). pp. 51-58. ISSN 0005-2736

Placebos

Christie, Michael R., Molvig, Jens, Hawkes, Charlotte J., Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

Plasmids

Zhao, M., Amiel, S. A., Christie, Michael R., Rela, M., Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Polyendocrinopathies, Autoimmune

Gylling, Mikhail, Tuomi, Tiinamaija, Bjorses, Petra, Kontiainen, Sirkka, Partanen, Jukka, Christie, Michael R., Knip, Mikael, Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

Morgenthaler, N. G., Seissler, J., Achenbach, P., Glawe, D., Payton, M., Meinck, H.-M., Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Wagner, R., Genovese, S., Bosi, E., Becker, F., Bingley, P. J., Bonifacio, E., Miles, K. A., Christie, Michael, Bottazzo, G. F. and Gale, E. A. M. (1994) Slow metabolic deterioration towards diabetes in islet cell antibody positive patients with autoimmune polyendocrine disease. Diabetologia, 37 (4). pp. 365-371. ISSN 0012-186X

Wagner, R., McNally, J. M., Bonifacio, E., Genovese, S., Foulis, A., McGill, M., Christie, M. R., Betterle, C., Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

Polymerase Chain Reaction

Payton, M. A., Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Polymorphism, Genetic

Winnock, Frederic, Christie, Michael R., Batstra, Manou R., Aanstoot, Henk-Jan, Weets, Ilse, Decochez, Katelijn, Jopart, Philippe, Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

Polyvinyl chloride

Eves, Paula, Bullet, Nial A., Haddow, David, Beck, Alison J., Layton, Christopher, Way, Louise, Shard, Alex G., Gawkrodger, David J. and MacNeil, Sheila (2008) Simplifying the delivery of melanocytes and keratinocytes for the treatment of vitiligo using a chemically defined carrier dressing. Journal of Investigative Dermatology, 128 (6). pp. 1554-1564. ISSN 0022-202X

Precipitin Tests

Baekkeskov, S., Warnock, G., Christie, M., Rajotte, R.V., Larsen, P.M. and Fey, S. (1989) Revelation of specificity of 64K autoantibodies in IDDM serums by high-resolution 2-D gel electrophoresis. Unambiguous identification of 64K target antigen. Diabetes, 38 (9). pp. 1133-1141. ISSN 0012-1797

Christie, M. R. (1993) Characterization of distinct islet protein auto antigens associated with type 1 diabetes. Autoimmunity, 15 (s1). pp. 1-3. ISSN 0891-6934

Christie, M. R., Daneman, D., Champagne, P. and Delovitch, T. L. (1990) Persistence of serum antibodies to 64,000-Mr islet cell protein after onset of type I diabetes. Diabetes, 39 (6). pp. 653-656. ISSN 0012-1797

Morgenthaler, N. G., Löbner, K., Morgenthaler, U. Y., Christie, M. R., Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Prediabetic State

Christie, M. R., Tun, R. Y. M., Lo, S. S. S., Cassidy, D., Brown, T. J., Hollands, J., Shattock, M., Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Winnock, Frederic, Christie, Michael R., Batstra, Manou R., Aanstoot, Henk-Jan, Weets, Ilse, Decochez, Katelijn, Jopart, Philippe, Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

Predictive Value of Tests

Bingley, P. J., Christie, M. R., Bonifacio, E., Bonfanti, R., Shattock, M., Fonte, M.-T., Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Christie, M. R., Genovese, S., Cassidy, D., Bosi, E., Brown, T. J., Lai, M., Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

Christie, Michael R., Molvig, Jens, Hawkes, Charlotte J., Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

Desai, M.a, Cull, C.A.b, Horton, V.A.a, Christie, M.R.c, Bonifacio, E.d, Lampasona, V.d, Bingley, P.J.e, Levy, J.C.a, Mackay, I.R.f, Zimmet, P.g, Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Hawa, M., Rowe, R., Lan, M. S., Notkins, A. L., Pozzilli, P., Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Winnock, Frederic, Christie, Michael R., Batstra, Manou R., Aanstoot, Henk-Jan, Weets, Ilse, Decochez, Katelijn, Jopart, Philippe, Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

Pregnancy

Damanhouri, L. H., Dromey, J. A., Christie, Michael R., Nasrat, H. A., Ardawi, M. S. M., Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Roll, U., Christie, M. R., Fuchtenbusch, M., Payton, M. A., Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Pregnancy in Diabetics

Roll, U., Christie, M. R., Fuchtenbusch, M., Payton, M. A., Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Prehospital ambulance care

Siriwardena, Niro, Akanuwe, Joseph, Crum, A, Coster, J, Jacques, R and Turner, J (2017) Preventable mortality in patients at low risk of death requiring prehospital ambulance care: structured judgment case note review. In: EUSEM Conference.

Prevalence

Gorus, F. K., Goubert, P., Semakula, C., Vandewalle, C. L., De Schepper, J., Scheen, A., Christie, Michael R. and Pipeleers, D. G. (1997) IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia, 40 (1). pp. 95-99. ISSN 0012-186X

Preventable mortality

Siriwardena, Niro, Akanuwe, Joseph, Crum, A, Coster, J, Jacques, R and Turner, J (2017) Preventable mortality in patients at low risk of death requiring prehospital ambulance care: structured judgment case note review. In: EUSEM Conference.

Primary care

Abuosi, Aaron Asibi, Akoriyea, Samuel Kaba, Ntow-Kummi, Gloria, Akanuwe, Joseph, Abor, Patience Aseweh, Daniels, Anita Anima and Alhassan, Robert Kaba (2020) Hand hygiene compliance among healthcare workers in Ghana’s health care institutions: An observational study. Journal of Patient Safety and Risk Management, 25 (5). pp. 177-186. ISSN 2516-0435

Akanuwe, J. N. A. and Siriwardena, A. N. (2017) Exploring service user and practitioner perspectives of QCancer use in primary care consultations [Pechakucha]. In: Cancer Research UK Early Diagnosis Research Conference, 23 - 24 February 2017, London.

Akanuwe, Joseph, Siriwardena, Niro, Black, Sharon and Owen, Sara (2017) Informing use of QCancer in the primary care consultation - perspectives of service users and practitioners. In: Cancer Research Early Diagnosis Research Conference, 23th-24th February 2017, London.

Siriwardena, Niro (2011) Quality in primary care 2011 [Editorial]. Quality in Primary Care, 19 (6). pp. 345-346. ISSN 1479-1072

Prospective Studies

Hawa, M., Rowe, R., Lan, M. S., Notkins, A. L., Pozzilli, P., Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Roll, U., Christie, M. R., Fuchtenbusch, M., Payton, M. A., Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Prostate cancer

Dagnelie, Pieter C., Bell, Jimmy D., Williams, Steve C., Bates, Timothy E., Abel, Paul D. and Foster, Christopher S. (1994) Effect of fish oil on cancer cachexia and host liver metabolism in rats with prostate tumors. Lipids, 29 (3). pp. 195-203. ISSN 0024-4201

Protein Footprinting

Bearzatto, Massimo, Naserke, Heike, Piquer, Sandra, Koczwara, Kerstin, Lampasona, Vito, Williams, Alistair, Christie, Michael R., Bingley, Polly J., Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Protein-Tyrosine-Phosphatase

Bearzatto, Massimo, Naserke, Heike, Piquer, Sandra, Koczwara, Kerstin, Lampasona, Vito, Williams, Alistair, Christie, Michael R., Bingley, Polly J., Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Christie, M. R. (1996) Islet cell autoantigens in type 1 diabetes. European Journal of Clinical Investigation, 26 (10). pp. 827-838. ISSN 0014-2972

Christie, Michael R., Roll, Ursula, Payton, Mark A., Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Hatfield, E. C. I., Hawkes, C. J., Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Hawa, M., Rowe, R., Lan, M. S., Notkins, A. L., Pozzilli, P., Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Hawkes, C. J., Wasmeier, C., Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Hawkes, C. J., Schloot, N. C., Marks, J., Willemen, S. J. M., Drijfhout, J. W., Mayer, E. K., Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

Morgenthaler, N. G., Löbner, K., Morgenthaler, U. Y., Christie, M. R., Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Morgenthaler, N. G., Seissler, J., Achenbach, P., Glawe, D., Payton, M., Meinck, H.-M., Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Payton, M. A., Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Piquer, Sandra, Valera, Lionel, Lampasona, Vito, Jardin-Watelet, Benedicte, Roche, Stephanie, Granier, Claude, Roquet, Francoise, Christie, Michael R., Giordano, Tiziana, Malosio, Maria-Luisa, Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

Roll, U., Christie, M. R., Fuchtenbusch, M., Payton, M. A., Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Seissler, J., Morgenthaler, N. G., Achenbach, P., Lampeter, E .F., Glawe, D., Payton, M., Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

Proteins

Christie, M. R., Daneman, D., Champagne, P. and Delovitch, T. L. (1990) Persistence of serum antibodies to 64,000-Mr islet cell protein after onset of type I diabetes. Diabetes, 39 (6). pp. 653-656. ISSN 0012-1797

Pulmonary arterial hypertension

Long, Lu, Ormiston, Mark L., Yang, Xudong, Southwood, Mark, Gräf, Stefan, Machado, Rajiv D., Mueller, Matthias, Kinzel, Bernd, Yung, Lai Ming, Wilkinson, Janine M., Moore, Stephen D., Drake, Kylie M., Aldred, Micheala A., Yu, Paul B., Upton, Paul D. and Morrell, Nicholas W. (2015) Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension. Nature Medicine, 21 (7). pp. 777-785. ISSN 1078-8956

QCancer

Akanuwe, J. N. A. and Siriwardena, A. N. (2017) Exploring service user and practitioner perspectives of QCancer use in primary care consultations [Pechakucha]. In: Cancer Research UK Early Diagnosis Research Conference, 23 - 24 February 2017, London.

Akanuwe, Joseph, Siriwardena, Niro, Black, Sharon and Owen, Sara (2017) Informing use of QCancer in the primary care consultation - perspectives of service users and practitioners. In: Cancer Research Early Diagnosis Research Conference, 23th-24th February 2017, London.

Akanuwe, Joseph, Siriwardena, Niro, Black, Sharon and Owen, Sara (2017) A systematic scoping review of the use of cancer risk assessment tools for early detection of cancer risk in primary care. In: Society for Academic Primary Care (SAPC) Regional Conference, 21 March 2017, Lincoln.

Qualitative

Curtis, Ffion, Laparidou, Despina, Akanuwe, N.A Joseph, Ellis-Vowles, Victoria, Jackson, Jennifer, Senevirathna, Mahendra, Menezes, Igor, Hodgson, Timothy and Siriwardena, A. Niroshan (2019) Patient experiences and perceptions of Guillain-Barré Syndrome and associated inflammatory neuropathies following discharge from hospital. PROSPERO: International prospective register of systematic reviews .

Qualitative systematic review and meta-synthesis

Laparidou, Despina, Curtis, Ffion, Akanuwe, Joseph, Jackson, Jennifer, Hodgson, Timothy and Siriwardena, Niro (2020) Patients’ experiences and perceptions of Guillain-Barré syndrome: a systematic review and meta-synthesis of qualitative research. In: SAPC ASM.

Quality of care

Akanuwe, Joseph, Goyder, E, O'Hara, R and Julious, S (2010) P05 Exploring the impact of the quality and outcomes framework on the quality of diabetes care and healthcare inequalities in England. Journal of Epidemiology & Community Health, 64 (A35). ISSN 0143-005X

RCT

Middleton, Geoff, Keegan, Richard, Smith, Mark F., Alkhatib, Ahmed and Klonizakis, Markos (2015) Implementing a Mediterranean diet intervention into a RCT: lessons learned from a non-Mediterranean based country. Journal of Nutrition, Health and Aging, 19 (10). pp. 1019-1022. ISSN 1279-7707

RUNX1

Li, Donglan, Sinha, Kislay K., Hay, Maher A., Rinaldi, Ciro R., Saunthararajah, Yogen and Nucifora, Giuseppina (2007) RUNX1-RUNX1 homodimerization modulates RUNX1 activity and function. The Journal of Biological Chemistry, 282 (18). pp. 13542-51. ISSN 0021-9258

RUNx1

Senyuk, Vitalyi, Sinha, Kislay K., Li, Donglan, Rinaldi, Ciro R., Yanamandra, Sastry and Nucifora, Giuseppina (2007) Repression of RUNX1 activity by EVI1: a new role of EVI1 in leukemogenesis. Cancer research, 67 (12). pp. 5658-5666. ISSN 1538-7445

Rabbits

Hawkes, C. J., Wasmeier, C., Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Radiation

Colley, Helen E., Eves, Paula, Pinnock, Abigail, Thornhill, Martin H. and Murdoch, Craig (2013) Tissue-engineered oral mucosa to study radiotherapy-induced oral mucositis. International Journal of Radiation Biology, 89 (11). pp. 907-914. ISSN 0955-3002

Radioimmunoprecipitation Assay

Damanhouri, L. H., Dromey, J. A., Christie, Michael R., Nasrat, H. A., Ardawi, M. S. M., Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Radioligand Assay

Morgenthaler, N. G., Löbner, K., Morgenthaler, U. Y., Christie, M. R., Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Seissler, J., Morgenthaler, N. G., Achenbach, P., Lampeter, E .F., Glawe, D., Payton, M., Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

Raffinose

Huang, Guo Cai, Zhao, Min, Jones, Peter, Persaud, Shanta, Ramracheya, Reshma, Lobner, Kristian, Christie, Michael R., Banga, J. Paul, Peakman, Mark, Sirinivsan, Parthi, Rela, Mohammed, Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Rats

Baekkeskov, S., Warnock, G., Christie, M., Rajotte, R.V., Larsen, P.M. and Fey, S. (1989) Revelation of specificity of 64K autoantibodies in IDDM serums by high-resolution 2-D gel electrophoresis. Unambiguous identification of 64K target antigen. Diabetes, 38 (9). pp. 1133-1141. ISSN 0012-1797

Christie, M. R. (1993) Characterization of distinct islet protein auto antigens associated with type 1 diabetes. Autoimmunity, 15 (s1). pp. 1-3. ISSN 0891-6934

Christie, M. R., Pipeleers, D. G., Lernmark, A. and Baekkeskov, S. (1990) Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes. Journal of Biological Chemistry, 265 (1). pp. 376-381. ISSN 0021-9258

Christie, M. R., Vohra, G., Champagne, P., Daneman, D. and Delovitch, T. L. (1990) Distinct antibody specificities to a 64-kD islet cell antigen in Type 1 diabetes as revealed by trypsin treatment. Journal of Experimental Medicine, 172 (3). pp. 789-794. ISSN 0022-1007

Christie, Michael, Brown, T. J. and Cassidy, D. (1992) Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme. Diabetologia, 35 (4). pp. 380-384. ISSN 0012-186X

Christie, Michael, Landin-Olsson, M., Sundkvist, G., Dahlquist, G., Lernmark, A. and Baekkeskov, S. (1988) Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes. Diabetologia, 31 (8). pp. 597-602. ISSN 0012-186X

Hansen, W.A., Christie, M.R., Kahn, R., Norgaard, A., Abel, I., Petersen, A.M., Jorgensen, D.W., Baekkeskov, S., Nielsen, J.H., Lernmark, A., Egeberg, J., Richter-Olesen, H., Grainger, T., Kristensen, J.K., Brynitz, S. and Bilde, T. (1989) Supravital dithizone staining in the isolation of human and rat pancreatic islets. Diabetes Research, 10 (2). pp. 53-57. ISSN 0265-5985

Hawkes, C. J., Wasmeier, C., Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Payton, M. A., Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Roll, U., Christie, M. R., Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

Rats, Inbred Strains

Baekkeskov, S., Warnock, G., Christie, M., Rajotte, R.V., Larsen, P.M. and Fey, S. (1989) Revelation of specificity of 64K autoantibodies in IDDM serums by high-resolution 2-D gel electrophoresis. Unambiguous identification of 64K target antigen. Diabetes, 38 (9). pp. 1133-1141. ISSN 0012-1797

Christie, M. R., Pipeleers, D. G., Lernmark, A. and Baekkeskov, S. (1990) Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes. Journal of Biological Chemistry, 265 (1). pp. 376-381. ISSN 0021-9258

Christie, Michael, Brown, T. J. and Cassidy, D. (1992) Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme. Diabetologia, 35 (4). pp. 380-384. ISSN 0012-186X

Christie, Michael, Landin-Olsson, M., Sundkvist, G., Dahlquist, G., Lernmark, A. and Baekkeskov, S. (1988) Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes. Diabetologia, 31 (8). pp. 597-602. ISSN 0012-186X

Rats, Wistar

Roll, U., Christie, M. R., Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

Recombinant Fusion Proteins

Bearzatto, Massimo, Naserke, Heike, Piquer, Sandra, Koczwara, Kerstin, Lampasona, Vito, Williams, Alistair, Christie, Michael R., Bingley, Polly J., Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Recombinant Proteins

Hatfield, E. C. I., Hawkes, C. J., Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Hawkes, C. J., Wasmeier, C., Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Payton, M. A., Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Seissler, J., Morgenthaler, N. G., Achenbach, P., Lampeter, E .F., Glawe, D., Payton, M., Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

Recombinant Proteins, Escherichia coli

Morgenthaler, N. G., Löbner, K., Morgenthaler, U. Y., Christie, M. R., Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Reference Values

Christie, M. R., Vohra, G., Champagne, P., Daneman, D. and Delovitch, T. L. (1990) Distinct antibody specificities to a 64-kD islet cell antigen in Type 1 diabetes as revealed by trypsin treatment. Journal of Experimental Medicine, 172 (3). pp. 789-794. ISSN 0022-1007

Christie, Michael, Brown, T. J. and Cassidy, D. (1992) Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme. Diabetologia, 35 (4). pp. 380-384. ISSN 0012-186X

Christie, Michael, Landin-Olsson, M., Sundkvist, G., Dahlquist, G., Lernmark, A. and Baekkeskov, S. (1988) Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes. Diabetologia, 31 (8). pp. 597-602. ISSN 0012-186X

Hawkes, C. J., Wasmeier, C., Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Payton, M. A., Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Roll, U., Christie, M. R., Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

Registries

Winnock, Frederic, Christie, Michael R., Batstra, Manou R., Aanstoot, Henk-Jan, Weets, Ilse, Decochez, Katelijn, Jopart, Philippe, Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

Regression Analysis

Christie, M. R., Tun, R. Y. M., Lo, S. S. S., Cassidy, D., Brown, T. J., Hollands, J., Shattock, M., Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Reperfusion

Almeida, Angeles, Allen, Kathryn L., Bates, TImothy E. and Clark, John B. (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. Journal of neurochemistry, 65 (4). pp. 1698-1703. ISSN 0022-3042

Reperfusion injury

Almeida, Angeles, Allen, Kathryn L., Bates, TImothy E. and Clark, John B. (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. Journal of neurochemistry, 65 (4). pp. 1698-1703. ISSN 0022-3042

Sammut, Ivan A., Jayakumar, Jay, Latif, Najmi, Rothery, Stephen, Severs, Nicholas J., Smolenski, Ryszard T., Bates, Timothy E. and Yacoub, Magdi H. (2001) Heat stress contributes to the enhancement of cardiac mitochondrial complex activity. The American Journal of Pathology, 158 (5). pp. 1821-31. ISSN 0002-9440

Reproducibility

Klonizakis, Markos, Manning, Gillian and Donnelly, Richard (2011) Assessment of lower limb microcirculation: exploring the reproducibility and clinical application of laser doppler techniques. Skin Pharmacology and Physiology: Journal of Pharmacological and Biophysical Research, 24 (3). pp. 136-143. ISSN 1660-5527

Tew, G., Klonizakis, Markos, Moss, J., Ruddock, A. D., Saxton, J. M. and Hodges, G. J. (2011) Reproducibility of cutaneous thermal hyperaemia assessed by laser Doppler flowmetry in young and older adults. Microvascular Research, 81 (2). pp. 177-182. ISSN 0026-2862

Reproducibility of Results

Christie, Michael R., Roll, Ursula, Payton, Mark A., Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Morgenthaler, N. G., Seissler, J., Achenbach, P., Glawe, D., Payton, M., Meinck, H.-M., Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Respiratory chain

Almeida, Angeles, Allen, Kathryn L., Bates, TImothy E. and Clark, John B. (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. Journal of neurochemistry, 65 (4). pp. 1698-1703. ISSN 0022-3042

Reverse Transcriptase Polymerase Chain Reaction

Zhao, M., Amiel, S. A., Christie, Michael R., Rela, M., Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Risk

Gillespie, Kathleen M., Bain, Steven C., Barnett, Anthony H., Bingley, Polly J., Christie, Michael R., Gill, Geoffrey V. and Gale, Edwin A. M. (2004) The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. The Lancet, 364 (9446). pp. 1699-1700. ISSN 0140-6736

Risk Assessment

Christie, Michael R., Roll, Ursula, Payton, Mark A., Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Risk Factors

Bearzatto, Massimo, Naserke, Heike, Piquer, Sandra, Koczwara, Kerstin, Lampasona, Vito, Williams, Alistair, Christie, Michael R., Bingley, Polly J., Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Christie, Michael R., Roll, Ursula, Payton, Mark A., Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Seissler, J., Morgenthaler, N. G., Achenbach, P., Lampeter, E .F., Glawe, D., Payton, M., Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

Running

Ruder, M., Jamison, S., Tenforde, A., Mulloy, F. and Davis, I. (2019) Relationship of Footstrike Pattern and Landing Impacts during a Marathon. Medicine and Science in Sports and Exercise, 51 (10). pp. 2073-2079. ISSN 0195-9131

S-nitrosothiols

Calabrese, Vittorio, Scapagnini, Giovanni, Ravagna, Agrippino, Bella, Rita, Foresti, Roberta, Bates, Timothy E., Giuffrida Stella, Anna-Maria and Pennisi, Giovanni (2002) Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels. Journal of Neuroscience Research, 70 (4). pp. 580-7. ISSN 0360-4012

SB366791

Athanasiou, Andriani, Smith, Paul A., Vakilpour, Sara, Kumaran, Nethia M., Turner, Amy E., Bagiokou, Dimitra, Layfield, Robert, Ray, David E., Westwell, Andrew D., Alexander, Stephen P. H., Kendall, David A., Lobo, Dileep N., Watson, Susan A., Lophatanon, Artitaya, Muir, Kenneth A., Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

SCID mouse

Zhao, M., Christie, M.R., Heaton, N., George, S., Amiel, S. and Huang, G.C. (2002) Amelioration of streptozotocin-induced diabetes in mice using human islet cells derived from long-term culture in vitro. Transplantation, 73 (9). pp. 1454-1460. ISSN 0041-1337

Zhao, M., Amiel, S. A., Christie, Michael R., Rela, M., Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

SCID mouse, Adenosine

Huang, Guo Cai, Zhao, Min, Jones, Peter, Persaud, Shanta, Ramracheya, Reshma, Lobner, Kristian, Christie, Michael R., Banga, J. Paul, Peakman, Mark, Sirinivsan, Parthi, Rela, Mohammed, Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Saudi Arabia

Damanhouri, L. H., Dromey, J. A., Christie, Michael R., Nasrat, H. A., Ardawi, M. S. M., Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Saudi Arabia, Adult

Damanhouri, L. H., Dromey, J. A., Christie, Michael R., Nasrat, H. A., Ardawi, M. S. M., Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Sensitivity and Specificity

Bingley, P. J., Christie, M. R., Bonifacio, E., Bonfanti, R., Shattock, M., Fonte, M.-T., Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Morgenthaler, N. G., Seissler, J., Achenbach, P., Glawe, D., Payton, M., Meinck, H.-M., Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Service Provision

French, Rebecca, Stephenson, Judith, Kane, Ros, Kingori, Patricia, Hadley, Alison and Wellings, Kaye (2004) How good is the provision of sexual health services for young people across England? In: 8th Congress of the European Society of Contraception, Edinburgh, June 2004, 23 - 26 June 2004, Edinburgh.

Sex Characteristics

Winnock, Frederic, Christie, Michael R., Batstra, Manou R., Aanstoot, Henk-Jan, Weets, Ilse, Decochez, Katelijn, Jopart, Philippe, Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

Sexual health

French, Rebecca, Stephenson, Judith, Kane, Ros, Kingori, Patricia, Hadley, Alison and Wellings, Kaye (2004) How good is the provision of sexual health services for young people across England? In: 8th Congress of the European Society of Contraception, Edinburgh, June 2004, 23 - 26 June 2004, Edinburgh.

Silicones

Eves, Paula, Bullet, Nial A., Haddow, David, Beck, Alison J., Layton, Christopher, Way, Louise, Shard, Alex G., Gawkrodger, David J. and MacNeil, Sheila (2008) Simplifying the delivery of melanocytes and keratinocytes for the treatment of vitiligo using a chemically defined carrier dressing. Journal of Investigative Dermatology, 128 (6). pp. 1554-1564. ISSN 0022-202X

Single cell PCR

Catani, Mara, Walther, Denise, Christie, Michael, McLaughlin, Kerry, Bonifacio, Ezio and Eugster, Anne (2015) Isolation of human monoclonal autoantibodies derived from pancreatic lymph node and peripheral blood B cells of islet autoantibody-positive patients. Diabetologia . ISSN 0012-186X

Skeletal Muscle

Bates, T. E., Loesch, A., Burnstock, G. and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochemical and biophysical research communications, 218 (1). pp. 40-44. ISSN 0006-291X

Skin blood flow

Klonizakis, Markos (2012) Studying the cutaneous microcirculatory response during upper-limb exercise in healthy, older, sedentary people. Clinical Hemorheology and Microcirculation, 51 (1). pp. 69-75. ISSN 1386-0281

Tew, G., Klonizakis, Markos, Moss, J., Ruddock, A. D., Saxton, J. M. and Hodges, G. J. (2011) Reproducibility of cutaneous thermal hyperaemia assessed by laser Doppler flowmetry in young and older adults. Microvascular Research, 81 (2). pp. 177-182. ISSN 0026-2862

Tew, G., Klonizakis, Markos, Moss, J., Ruddock, A., Saxton, J. M. and Hodges, G. (2010) Role of sensory nerves in the rapid cutaneous vasodilator response to local heating in young and older endurance-trained and untrained men. In: 9th World Congress on Microcirculation, 26 - 28 September 2010, Maison de la Chimie, Paris.

Tew, G. A., Saxton, J. M., Klonizakis, Markos, Moss, J., Ruddock, A. D. and Hodges, G. J. (2011) Aging and aerobic fitness affect the contribution of noradrenergic sympathetic nerves to the rapid cutaneous vasodilator response to local heating. Journal of Applied Physiology, 110 (5). pp. 1264-1270. ISSN 8750-7587

Skin transplantation

Eves, Paula, Bullet, Nial A., Haddow, David, Beck, Alison J., Layton, Christopher, Way, Louise, Shard, Alex G., Gawkrodger, David J. and MacNeil, Sheila (2008) Simplifying the delivery of melanocytes and keratinocytes for the treatment of vitiligo using a chemically defined carrier dressing. Journal of Investigative Dermatology, 128 (6). pp. 1554-1564. ISSN 0022-202X

Social Work

Golightley, Malcolm and Goemans, Robert (2017) Social work and mental health. 6th Edition. Transforming Social Work Practice . Learning Matters. ISBN 9781473989290

Somatostatin

Wagner, R., McNally, J. M., Bonifacio, E., Genovese, S., Foulis, A., McGill, M., Christie, M. R., Betterle, C., Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

Spectrofluorimetry.

Al-Haj Sakur, Amir, Chalati, Tamim and Fael, Hanan (2015) Selective Spectrofluorimetric Method for the Determination of Perindopril Erbumine in Bulk and Tablets through Derivatization with O-Phthalaldehyde in Presence of 3-Mercaptopropionic Acid. International Journal of Academic Scientific Research, 3 (2). pp. 26-37. ISSN 2272-6446

Stiff-Person Syndrome

Christie, M. R., Genovese, S., Cassidy, D., Bosi, E., Brown, T. J., Lai, M., Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

Morgenthaler, N. G., Seissler, J., Achenbach, P., Glawe, D., Payton, M., Meinck, H.-M., Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Sulfur Radioisotopes

Christie, Michael, Landin-Olsson, M., Sundkvist, G., Dahlquist, G., Lernmark, A. and Baekkeskov, S. (1988) Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes. Diabetologia, 31 (8). pp. 597-602. ISSN 0012-186X

Support, Non-U.S. Gov't

Baekkeskov, S., Warnock, G., Christie, M., Rajotte, R.V., Larsen, P.M. and Fey, S. (1989) Revelation of specificity of 64K autoantibodies in IDDM serums by high-resolution 2-D gel electrophoresis. Unambiguous identification of 64K target antigen. Diabetes, 38 (9). pp. 1133-1141. ISSN 0012-1797

Bottazzo, G. F., Genovese, S., Bosi, E., Dean, B. M., Christie, M. R. and Bonifacio, E. (1991) Novel considerations on the antibody/autoantigen system in type I (insulin-dependent) diabetes mellitus. Annals of Medicine, 23 (4). pp. 453-461. ISSN 0785-3890

Christie, M. R., Daneman, D., Champagne, P. and Delovitch, T. L. (1990) Persistence of serum antibodies to 64,000-Mr islet cell protein after onset of type I diabetes. Diabetes, 39 (6). pp. 653-656. ISSN 0012-1797

Christie, M. R., Genovese, S., Cassidy, D., Bosi, E., Brown, T. J., Lai, M., Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

Christie, M. R., Pipeleers, D. G., Lernmark, A. and Baekkeskov, S. (1990) Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes. Journal of Biological Chemistry, 265 (1). pp. 376-381. ISSN 0021-9258

Christie, M. R., Tun, R. Y. M., Lo, S. S. S., Cassidy, D., Brown, T. J., Hollands, J., Shattock, M., Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Christie, M. R., Vohra, G., Champagne, P., Daneman, D. and Delovitch, T. L. (1990) Distinct antibody specificities to a 64-kD islet cell antigen in Type 1 diabetes as revealed by trypsin treatment. Journal of Experimental Medicine, 172 (3). pp. 789-794. ISSN 0022-1007

Christie, Michael, Brown, T. J. and Cassidy, D. (1992) Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme. Diabetologia, 35 (4). pp. 380-384. ISSN 0012-186X

Christie, Michael, Landin-Olsson, M., Sundkvist, G., Dahlquist, G., Lernmark, A. and Baekkeskov, S. (1988) Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes. Diabetologia, 31 (8). pp. 597-602. ISSN 0012-186X

Christie, M. R., Hollands, J. A., Brown, T. J., Michelsen, B. K. and Delovitch, T. L. (1993) Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. Journal of Clinical Investigation, 92 (1). pp. 240-248. ISSN 0021-9738

Hansen, W.A., Christie, M.R., Kahn, R., Norgaard, A., Abel, I., Petersen, A.M., Jorgensen, D.W., Baekkeskov, S., Nielsen, J.H., Lernmark, A., Egeberg, J., Richter-Olesen, H., Grainger, T., Kristensen, J.K., Brynitz, S. and Bilde, T. (1989) Supravital dithizone staining in the isolation of human and rat pancreatic islets. Diabetes Research, 10 (2). pp. 53-57. ISSN 0265-5985

Payton, M. A., Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Roll, U., Christie, M. R., Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

Wagner, R., Genovese, S., Bosi, E., Becker, F., Bingley, P. J., Bonifacio, E., Miles, K. A., Christie, Michael, Bottazzo, G. F. and Gale, E. A. M. (1994) Slow metabolic deterioration towards diabetes in islet cell antibody positive patients with autoimmune polyendocrine disease. Diabetologia, 37 (4). pp. 365-371. ISSN 0012-186X

Support, U.S. Gov't, P.H.S.

Christie, M. R., Pipeleers, D. G., Lernmark, A. and Baekkeskov, S. (1990) Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes. Journal of Biological Chemistry, 265 (1). pp. 376-381. ISSN 0021-9258

Christie, Michael, Landin-Olsson, M., Sundkvist, G., Dahlquist, G., Lernmark, A. and Baekkeskov, S. (1988) Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes. Diabetologia, 31 (8). pp. 597-602. ISSN 0012-186X

Hansen, W.A., Christie, M.R., Kahn, R., Norgaard, A., Abel, I., Petersen, A.M., Jorgensen, D.W., Baekkeskov, S., Nielsen, J.H., Lernmark, A., Egeberg, J., Richter-Olesen, H., Grainger, T., Kristensen, J.K., Brynitz, S. and Bilde, T. (1989) Supravital dithizone staining in the isolation of human and rat pancreatic islets. Diabetes Research, 10 (2). pp. 53-57. ISSN 0265-5985

Surface engineered carriers

MacNeil, Sheila and Eves, Paula (2006) Simplifying the delivery of cultured melanocytes and keratinocytes for grafting patients with vitiligo. In: Surgical management of vitiligo. Blackwell Publishing Ltd, pp. 191-202. ISBN 1405145218, 9781405145213

Suspected convulsions

Asghar, Zahid, Dickson, Jon and Siriwardena, Niro (2016) Exploratory cross-sectional study of factors associated with transport to hospital in patients with suspected convulsions presenting to ambulance services. In: College of Social Science Research Showcase, 4 July 2016, University of Lincoln.

Sweden

Christie, Michael, Landin-Olsson, M., Sundkvist, G., Dahlquist, G., Lernmark, A. and Baekkeskov, S. (1988) Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes. Diabetologia, 31 (8). pp. 597-602. ISSN 0012-186X

Synaptic

Almeida, A., Brooks, K. J., Sammut, I., Keelan, J., Davey, G. P., Clark, J. B. and Bates, T. E. (1995) Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain. Developmental neuroscience, 17 (4). pp. 212-218. ISSN 0378-5866

Synaptosomal

Almeida, A., Brooks, K. J., Sammut, I., Keelan, J., Davey, G. P., Clark, J. B. and Bates, T. E. (1995) Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain. Developmental Neuroscience, 17 (4). pp. 212-218. ISSN 0378-5866

Bates, T. E, Loesch, A., Burnstock, G. and Clark, J. B. (1995) Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver. Biochemical and biophysical research communications, 213 (3). pp. 896-900. ISSN 0006-291X

Synaptosomes

Allen, Kathryn L., Almeida, Angeles, Bates, Timothy E. and Clark, John B. (1995) Changes of respiratory chain activity in mitochondrial and synaptosomal fractions isolated from the gerbil brain after graded ischaemia. Journal of neurochemistry, 64 (5). pp. 2222-2229. ISSN 0022-3042

Almeida, A., Brooks, K. J., Sammut, I., Keelan, J., Davey, G. P., Clark, J. B. and Bates, T. E. (1995) Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain. Developmental neuroscience, 17 (4). pp. 212-218. ISSN 0378-5866

Keelan, J., Brand, M. P., Bates, T. E., Land, J. M., Clark, J. B. and Heales, S. J. (1996) Nitric oxide and antioxidant status in glucose and oxygen deprived neonatal and adult rat brain synaptosomes. Neurochemical Research, 21 (8). pp. 923-7. ISSN 0364-3190

Keelan, Julie, Bates, Timothy E. and Clark, John B. (1999) Heightened resistance of the neonatal brain to ischemia-reperfusion involves a lack of mitochondrial damage in the nerve terminal. Brain research, 821 (1). pp. 124-33. ISSN 0006-8993

Keelan, Julie, Bates, Timothy E. and Clark, John B. (1996) Intrasynaptosomal free calcium concentration during rat brain development: effects of hypoxia, aglycaemia, and ischaemia. Journal of neurochemistry, 66 (6). pp. 2460-7. ISSN 0022-3042

Systematic review

Curtis, Ffion, Laparidou, Despina, Akanuwe, N.A Joseph, Ellis-Vowles, Victoria, Jackson, Jennifer, Senevirathna, Mahendra, Menezes, Igor, Hodgson, Timothy and Siriwardena, A. Niroshan (2019) Patient experiences and perceptions of Guillain-Barré Syndrome and associated inflammatory neuropathies following discharge from hospital. PROSPERO: International prospective register of systematic reviews .

T lymphocyte, Adolescent

Hawkes, C. J., Schloot, N. C., Marks, J., Willemen, S. J. M., Drijfhout, J. W., Mayer, E. K., Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

T-Lymphocytes

Hawkes, C. J., Schloot, N. C., Marks, J., Willemen, S. J. M., Drijfhout, J. W., Mayer, E. K., Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

TASTPM

Pardon, Marie-Christine, Sarmad, Sarir, Rattray, Ivan, Bates, Timothy E., Scullion, Gillian A., Marsden, Charles A., Barrett, David A., Lowe, James and Kendall, David A. (2009) Repeated novel cage exposure-induced improvement of early Alzheimer's-like cognitive and amyloid changes in TASTPM mice is unrelated to changes in brain endocannabinoids levels. Neurobiology of Aging, 30 (7). pp. 1099-1113. ISSN 0197-4580

THC

Athanasiou, Andriani, Clarke, Anna B., Turner, Amy E., Kumaran, Nethia M., Vakilpour, Sara, Smith, Paul A., Bagiokou, Dimitra, Bradshaw, Tracey D., Westwell, Andrew D., Fang, Lin, Lobo, Dileep N., Constantinescu, Cris S., Calabrese, Vittorio, Loesch, Andrzej, Alexander, Stephen P. H., Clothier, Richard H., Kendall, David A. and Bates, Timothy E. (2007) Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications, 364 (1). pp. 131-137. ISSN 0006-291x

TRPV1

Athanasiou, Andriani, Smith, Paul A., Vakilpour, Sara, Kumaran, Nethia M., Turner, Amy E., Bagiokou, Dimitra, Layfield, Robert, Ray, David E., Westwell, Andrew D., Alexander, Stephen P. H., Kendall, David A., Lobo, Dileep N., Watson, Susan A., Lophatanon, Artitaya, Muir, Kenneth A., Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

Time Factors

Christie, Michael R., Roll, Ursula, Payton, Mark A., Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Christie, Michael R., Molvig, Jens, Hawkes, Charlotte J., Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

Desai, M.a, Cull, C.A.b, Horton, V.A.a, Christie, M.R.c, Bonifacio, E.d, Lampasona, V.d, Bingley, P.J.e, Levy, J.C.a, Mackay, I.R.f, Zimmet, P.g, Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Roll, U., Christie, M. R., Fuchtenbusch, M., Payton, M. A., Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Zhao, M., Christie, M.R., Heaton, N., George, S., Amiel, S. and Huang, G.C. (2002) Amelioration of streptozotocin-induced diabetes in mice using human islet cells derived from long-term culture in vitro. Transplantation, 73 (9). pp. 1454-1460. ISSN 0041-1337

Tissue Distribution

Christie, M. R., Pipeleers, D. G., Lernmark, A. and Baekkeskov, S. (1990) Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes. Journal of Biological Chemistry, 265 (1). pp. 376-381. ISSN 0021-9258

Tissue Survival

Huang, Guo Cai, Zhao, Min, Jones, Peter, Persaud, Shanta, Ramracheya, Reshma, Lobner, Kristian, Christie, Michael R., Banga, J. Paul, Peakman, Mark, Sirinivsan, Parthi, Rela, Mohammed, Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Tissue and Organ Harvesting

Huang, Guo Cai, Zhao, Min, Jones, Peter, Persaud, Shanta, Ramracheya, Reshma, Lobner, Kristian, Christie, Michael R., Banga, J. Paul, Peakman, Mark, Sirinivsan, Parthi, Rela, Mohammed, Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Tissue engineering

Eves, Paula, Bullet, Nial A., Haddow, David, Beck, Alison J., Layton, Christopher, Way, Louise, Shard, Alex G., Gawkrodger, David J. and MacNeil, Sheila (2008) Simplifying the delivery of melanocytes and keratinocytes for the treatment of vitiligo using a chemically defined carrier dressing. Journal of Investigative Dermatology, 128 (6). pp. 1554-1564. ISSN 0022-202X

Trandolapril

ALHAJ SAKUR, Amir, Chalati, Tamim and Fael, Hanan (2015) NEW FLUORESCENCE QUENCHING BASED METHOD FOR THE DETERMINATION OF TRANDOLAPRIL IN BULK AND CAPSULES. International Journal of Pharmacy and Pharmaceutical Sciences, 7 (3). pp. 223-227. ISSN 0975-1491

Trans-Activators

Zhao, M., Amiel, S. A., Christie, Michael R., Rela, M., Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Transfection

Zhao, M., Amiel, S. A., Christie, Michael R., Rela, M., Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

Transplantation

Sammut, Ivan A., Thorniley, Maureen S., Simpkin, Sandra, Fuller, Barry J., Bates, Timothy E. and Green, Colin J. (1998) Impairment of hepatic mitochondrial respiratory function following storage and orthotopic transplantation of rat livers. Cryobiology, 36 (1). pp. 49-60. ISSN 0011-2240

Trypsin

Bearzatto, Massimo, Naserke, Heike, Piquer, Sandra, Koczwara, Kerstin, Lampasona, Vito, Williams, Alistair, Christie, Michael R., Bingley, Polly J., Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Payton, M. A., Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Trypsin, Human herpesvirus 4

Tremble, Jennifer, Morgenthaler, Nils G., Vlug, Arjen, Powers, Alvin C., Christie, Michael R., Scherbaum, Werner A. and Banga, J. Paul (1997) Human B cells secreting immunoglobulin G to glutamic acid decarboxylase- 65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes. Journal of Clinical Endocrinology and Metabolism, 82 (8). pp. 2664-2670. ISSN 0021-972X

Twins, Dizygotic

Hawa, M., Rowe, R., Lan, M. S., Notkins, A. L., Pozzilli, P., Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Twins, Monozygotic

Christie, M. R., Tun, R. Y. M., Lo, S. S. S., Cassidy, D., Brown, T. J., Hollands, J., Shattock, M., Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Hawa, M., Rowe, R., Lan, M. S., Notkins, A. L., Pozzilli, P., Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Type 1 diabetes

Catani, Mara, Walther, Denise, Christie, Michael, McLaughlin, Kerry, Bonifacio, Ezio and Eugster, Anne (2015) Isolation of human monoclonal autoantibodies derived from pancreatic lymph node and peripheral blood B cells of islet autoantibody-positive patients. Diabetologia . ISSN 0012-186X

McLaughlin, Kerry A., Richardson, Carolyn C., Williams, Stefan, Bonifacio, Ezio, Morgan, Diana, Feltbower, Richard G., Powell, Michael, Rees Smith, Bernard, Furmaniak, Jadwiga and Christie, Michael R. (2015) Relationships between major epitopes of the IA-2 autoantigen in Type 1 diabetes: implications for determinant spreading. Clinical Immunology, 160 (2). pp. 226-236. ISSN 1521-6616

United Kingdom, Adult

Desai, M.a, Cull, C.A.b, Horton, V.A.a, Christie, M.R.c, Bonifacio, E.d, Lampasona, V.d, Bingley, P.J.e, Levy, J.C.a, Mackay, I.R.f, Zimmet, P.g, Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Vanilloid

Athanasiou, Andriani, Smith, Paul A., Vakilpour, Sara, Kumaran, Nethia M., Turner, Amy E., Bagiokou, Dimitra, Layfield, Robert, Ray, David E., Westwell, Andrew D., Alexander, Stephen P. H., Kendall, David A., Lobo, Dileep N., Watson, Susan A., Lophatanon, Artitaya, Muir, Kenneth A., Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

Vanilloids

Athanasiou, Andriani, Smith, Paul A., Vakilpour, Sara, Kumaran, Nethia M., Turner, Amy E., Bagiokou, Dimitra, Layfield, Robert, Ray, David E., Westwell, Andrew D., Alexander, Stephen P. H., Kendall, David A., Lobo, Dileep N., Watson, Susan A., Lophatanon, Artitaya, Muir, Kenneth A., Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

Vitiligo

Eves, Paula, Bullet, Nial A., Haddow, David, Beck, Alison J., Layton, Christopher, Way, Louise, Shard, Alex G., Gawkrodger, David J. and MacNeil, Sheila (2008) Simplifying the delivery of melanocytes and keratinocytes for the treatment of vitiligo using a chemically defined carrier dressing. Journal of Investigative Dermatology, 128 (6). pp. 1554-1564. ISSN 0022-202X

Vitiligo grafting

MacNeil, Sheila and Eves, Paula (2006) Simplifying the delivery of cultured melanocytes and keratinocytes for grafting patients with vitiligo. In: Surgical management of vitiligo. Blackwell Publishing Ltd, pp. 191-202. ISBN 1405145218, 9781405145213

Wellbeing

Hodgson, Jessica and Bretherton, Roger (2020) Twelve tips for novice academic staff supporting medical students in distress. Medical Teacher . ISSN 0142-159X

Hodgson, Jessica and Hagan, Pamela (2020) Medical Education Adaptations During a Pandemic: Transitioning to Virtual Student Support. Medical Education . ISSN 1365-2923

Young people

French, Rebecca, Stephenson, Judith, Kane, Ros, Kingori, Patricia, Hadley, Alison and Wellings, Kaye (2004) How good is the provision of sexual health services for young people across England? In: 8th Congress of the European Society of Contraception, Edinburgh, June 2004, 23 - 26 June 2004, Edinburgh.

acetyl carnitine

Calabrese, V., Scapagnini, G., Catalano, C., Dinotta, F., Bates, T. E., Calvani, M. and Stella, A. M. (2001) Effects of acetyl-L-carnitine on the formation of fatty acid ethyl esters in brain and peripheral organs after short-term ethanol administration in rat. Neurochemical Research, 26 (2). pp. 167-74. ISSN 0364-3190

acetyl-L-carnitine

Mancuso, Cesare, Bates, Timothy E., Butterfield, D. Allan, Calafato, Stella, Cornelius, Carolin, De Lorenzo, Antonino, Dinkova Kostova, Albena T. and Calabrese, Vittorio (2007) Natural antioxidants in Alzheimer's disease. Expert Opinion on Investigational Drugs, 16 (12). pp. 1921-1931. ISSN 1354-3784

activin A

Zhao, M., Amiel, S. A., Christie, Michael R., Rela, M., Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

acute myeloid leukaemia

Boasman, Kristian, Simmonds, Matthew and Rinaldi, Ciro (2018) CALR and CD47: An insight into their roles in the disease progression of MDS and MPN. Journal of Blood Disorders & Transfusion . ISSN 2155-9864

adiponectin

Winzer, Brooke M., Paratz, Jennifer D., Whitehead, Jonathan P., Whiteman, David C. and Reeves, Marina M. (2015) The feasibility of an exercise intervention in males at risk of oesophageal adenocarcinoma: a randomized controlled trial. PLoS ONE, 10 (2). ISSN 1932-6203

adult

Bearzatto, Massimo, Naserke, Heike, Piquer, Sandra, Koczwara, Kerstin, Lampasona, Vito, Williams, Alistair, Christie, Michael R., Bingley, Polly J., Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Bingley, P. J., Christie, M. R., Bonifacio, E., Bonfanti, R., Shattock, M., Fonte, M.-T., Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Christie, Michael, Brown, T. J. and Cassidy, D. (1992) Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme. Diabetologia, 35 (4). pp. 380-384. ISSN 0012-186X

Christie, Michael R., Roll, Ursula, Payton, Mark A., Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Christie, Michael R., Molvig, Jens, Hawkes, Charlotte J., Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

Gorus, F. K., Goubert, P., Semakula, C., Vandewalle, C. L., De Schepper, J., Scheen, A., Christie, Michael R. and Pipeleers, D. G. (1997) IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia, 40 (1). pp. 95-99. ISSN 0012-186X

Gylling, Mikhail, Tuomi, Tiinamaija, Bjorses, Petra, Kontiainen, Sirkka, Partanen, Jukka, Christie, Michael R., Knip, Mikael, Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

Hatfield, E. C. I., Hawkes, C. J., Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Hawa, M., Rowe, R., Lan, M. S., Notkins, A. L., Pozzilli, P., Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Morgenthaler, N. G., Löbner, K., Morgenthaler, U. Y., Christie, M. R., Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Roll, U., Christie, M. R., Fuchtenbusch, M., Payton, M. A., Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

Roll, U., Christie, M. R., Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

Seissler, J., Morgenthaler, N. G., Achenbach, P., Lampeter, E .F., Glawe, D., Payton, M., Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

Winnock, Frederic, Christie, Michael R., Batstra, Manou R., Aanstoot, Henk-Jan, Weets, Ilse, Decochez, Katelijn, Jopart, Philippe, Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992

adverse drug reactions

Boateng, Irene, Pascual, Carlos, Asghar, Zahid and Grassby, Paul (2020) The Impact of Poly-Pharmacy on Mortality, Hospitalisation, Adverse Drug Reactions (ADR) and Falls in the Elderly. In: Prescribing and Research in Medicines Management, 15 Jan 2020, University of Manchester.

aerobic exercise

Winzer, Brooke M., Paratz, Jennifer D., Whitehead, Jonathan P., Whiteman, David C. and Reeves, Marina M. (2015) The feasibility of an exercise intervention in males at risk of oesophageal adenocarcinoma: a randomized controlled trial. PLoS ONE, 10 (2). ISSN 1932-6203

age

Tew, G. A., Saxton, J. M., Klonizakis, Markos, Moss, J., Ruddock, A. D. and Hodges, G. J. (2011) Aging and aerobic fitness affect the contribution of noradrenergic sympathetic nerves to the rapid cutaneous vasodilator response to local heating. Journal of Applied Physiology, 110 (5). pp. 1264-1270. ISSN 8750-7587

age distribution

Seissler, J., Morgenthaler, N. G., Achenbach, P., Lampeter, E .F., Glawe, D., Payton, M., Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X

Winzer, Brooke M., Paratz, Jennifer D., Whitehead, Jonathan P., Whiteman, David C. and Reeves, Marina M. (2015) The feasibility of an exercise intervention in males at risk of oesophageal adenocarcinoma: a randomized controlled trial. PLoS ONE, 10 (2). ISSN 1932-6203

aged

Christie, M. R., Genovese, S., Cassidy, D., Bosi, E., Brown, T. J., Lai, M., Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

Christie, Michael, Brown, T. J. and Cassidy, D. (1992) Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme. Diabetologia, 35 (4). pp. 380-384. ISSN 0012-186X

Damanhouri, L. H., Dromey, J. A., Christie, Michael R., Nasrat, H. A., Ardawi, M. S. M., Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Desai, M.a, Cull, C.A.b, Horton, V.A.a, Christie, M.R.c, Bonifacio, E.d, Lampasona, V.d, Bingley, P.J.e, Levy, J.C.a, Mackay, I.R.f, Zimmet, P.g, Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Lampeter, E. F., Kolb, H., Seifert, I., Lohmann, D., Heise, J. W., Bertrams, J., Christie, Michael and Kolb-Bachofen, V. (1994) Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity. Diabetologia, 37 (5). pp. 471-475. ISSN 0012-186X

Morgenthaler, N. G., Löbner, K., Morgenthaler, U. Y., Christie, M. R., Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Morgenthaler, N. G., Seissler, J., Achenbach, P., Glawe, D., Payton, M., Meinck, H.-M., Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

Wagner, R., McNally, J. M., Bonifacio, E., Genovese, S., Foulis, A., McGill, M., Christie, M. R., Betterle, C., Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

Winzer, Brooke M., Paratz, Jennifer D., Whitehead, Jonathan P., Whiteman, David C. and Reeves, Marina M. (2015) The feasibility of an exercise intervention in males at risk of oesophageal adenocarcinoma: a randomized controlled trial. PLoS ONE, 10 (2). ISSN 1932-6203

aging

Calabrese, V., Scapagnini, G., Giuffrida Stella, A. M., Bates, T. E. and Clark, J. B. (2001) Mitochondrial involvement in brain function and dysfunction: relevance to aging, neurodegenerative disorders and longevity. Neurochemical Research, 26 (6). pp. 739-64. ISSN 0364-3190

aglycemia

Brooks, K. J., Clark, J. B. and Bates, T. E. (1996) Assessment of energy metabolism in the developing brain following aglycemic hypoxia by 1H and 31P NMR. Neurochemical Research, 21 (9). pp. 1089-1095. ISSN 0364-3190

Brooks, K. J., Hargreaves, I. P. and Bates, T. E. (2000) Nitric-oxide-induced inhibition of mitochondrial complexes following aglycaemic hypoxia in neonatal cortical rat brain slices. Developmental Neuroscience, 22 (5-6). pp. 359-65. ISSN 0378-5866

Brooks, Keith J., Clark, John B. and Bates, Timothy E. (1998) 3-Hydroxybutyrate aids the recovery of the energy state from aglycaemic hypoxia of adult but not neonatal rat brain slices. Journal of Neurochemistry, 70 (5). pp. 1986-1990. ISSN 0022-3042

Keelan, J., Brand, M. P., Bates, T. E., Land, J. M., Clark, J. B. and Heales, S. J. (1996) Nitric oxide and antioxidant status in glucose and oxygen deprived neonatal and adult rat brain synaptosomes. Neurochemical Research, 21 (8). pp. 923-7. ISSN 0364-3190

Keelan, Julie, Bates, Timothy E. and Clark, John B. (1996) Intrasynaptosomal free calcium concentration during rat brain development: effects of hypoxia, aglycaemia, and ischaemia. Journal of neurochemistry, 66 (6). pp. 2460-7. ISSN 0022-3042

algorithm

Bingley, P. J., Christie, M. R., Bonifacio, E., Bonfanti, R., Shattock, M., Fonte, M.-T., Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

allele

Gylling, Mikhail, Tuomi, Tiinamaija, Bjorses, Petra, Kontiainen, Sirkka, Partanen, Jukka, Christie, Michael R., Knip, Mikael, Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

ambulance services

Asghar, Zahid, Dickson, Jon and Siriwardena, Niro (2016) Exploratory cross-sectional study of factors associated with transport to hospital in patients with suspected convulsions presenting to ambulance services. In: College of Social Science Research Showcase, 4 July 2016, University of Lincoln.

amino acid

Bearzatto, Massimo, Naserke, Heike, Piquer, Sandra, Koczwara, Kerstin, Lampasona, Vito, Williams, Alistair, Christie, Michael R., Bingley, Polly J., Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

amino terminal sequence

Desai, M.a, Cull, C.A.b, Horton, V.A.a, Christie, M.R.c, Bonifacio, E.d, Lampasona, V.d, Bingley, P.J.e, Levy, J.C.a, Mackay, I.R.f, Zimmet, P.g, Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

amyloid

Canevari, Laura, Clark, John B. and Bates, Timothy E. (1999) Beta-amyloid fragment 25-35 selectively decreases complex IV activity in isolated mitochondria. FEBS Letters, 457 (1). pp. 131-4. ISSN 0014-5793

amyloid precursor protein

Canevari, Laura, Clark, John B. and Bates, Timothy E. (1999) Beta-amyloid fragment 25-35 selectively decreases complex IV activity in isolated mitochondria. FEBS Letters, 457 (1). pp. 131-4. ISSN 0014-5793

Pardon, Marie-Christine, Sarmad, Sarir, Rattray, Ivan, Bates, Timothy E., Scullion, Gillian A., Marsden, Charles A., Barrett, David A., Lowe, James and Kendall, David A. (2009) Repeated novel cage exposure-induced improvement of early Alzheimer's-like cognitive and amyloid changes in TASTPM mice is unrelated to changes in brain endocannabinoids levels. Neurobiology of Aging, 30 (7). pp. 1099-1113. ISSN 0197-4580

anandamide

Athanasiou, Andriani, Clarke, Anna B., Turner, Amy E., Kumaran, Nethia M., Vakilpour, Sara, Smith, Paul A., Bagiokou, Dimitra, Bradshaw, Tracey D., Westwell, Andrew D., Fang, Lin, Lobo, Dileep N., Constantinescu, Cris S., Calabrese, Vittorio, Loesch, Andrzej, Alexander, Stephen P. H., Clothier, Richard H., Kendall, David A. and Bates, Timothy E. (2007) Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications, 364 (1). pp. 131-137. ISSN 0006-291x

animal

Hasnain, Sumaira Z., Borg, Danielle J., Harcourt, Brooke E., Tong, Hui, Sheng, Yonhua H., Ng, Choa ping, Das, Indrajit, Wang, Ran, Chen, Alice C.-H., Loudovaris, Thomas, Kay, Thomas W., Thomas, Helen E., Whitehead, Jonathan P., Forbes, Josephine M., Prins, Johannes B. and McGuckin, Michael A. (2014) Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress. Nature Medicine, 20 (12). pp. 1417-1426. ISSN 1078-8956

animal cell

Payton, M. A., Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

animal experiment

Hasnain, Sumaira Z., Borg, Danielle J., Harcourt, Brooke E., Tong, Hui, Sheng, Yonhua H., Ng, Choa ping, Das, Indrajit, Wang, Ran, Chen, Alice C.-H., Loudovaris, Thomas, Kay, Thomas W., Thomas, Helen E., Whitehead, Jonathan P., Forbes, Josephine M., Prins, Johannes B. and McGuckin, Michael A. (2014) Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress. Nature Medicine, 20 (12). pp. 1417-1426. ISSN 1078-8956

Piquer, Sandra, Valera, Lionel, Lampasona, Vito, Jardin-Watelet, Benedicte, Roche, Stephanie, Granier, Claude, Roquet, Francoise, Christie, Michael R., Giordano, Tiziana, Malosio, Maria-Luisa, Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

animal model

Hasnain, Sumaira Z., Borg, Danielle J., Harcourt, Brooke E., Tong, Hui, Sheng, Yonhua H., Ng, Choa ping, Das, Indrajit, Wang, Ran, Chen, Alice C.-H., Loudovaris, Thomas, Kay, Thomas W., Thomas, Helen E., Whitehead, Jonathan P., Forbes, Josephine M., Prins, Johannes B. and McGuckin, Michael A. (2014) Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress. Nature Medicine, 20 (12). pp. 1417-1426. ISSN 1078-8956

Zhao, M., Christie, M.R., Heaton, N., George, S., Amiel, S. and Huang, G.C. (2002) Amelioration of streptozotocin-induced diabetes in mice using human islet cells derived from long-term culture in vitro. Transplantation, 73 (9). pp. 1454-1460. ISSN 0041-1337

Zhao, M., Amiel, S. A., Christie, Michael R., Rela, M., Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X

animal tissue

Christie, Michael, Brown, T. J. and Cassidy, D. (1992) Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme. Diabetologia, 35 (4). pp. 380-384. ISSN 0012-186X

Hasnain, Sumaira Z., Borg, Danielle J., Harcourt, Brooke E., Tong, Hui, Sheng, Yonhua H., Ng, Choa ping, Das, Indrajit, Wang, Ran, Chen, Alice C.-H., Loudovaris, Thomas, Kay, Thomas W., Thomas, Helen E., Whitehead, Jonathan P., Forbes, Josephine M., Prins, Johannes B. and McGuckin, Michael A. (2014) Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress. Nature Medicine, 20 (12). pp. 1417-1426. ISSN 1078-8956

Piquer, Sandra, Valera, Lionel, Lampasona, Vito, Jardin-Watelet, Benedicte, Roche, Stephanie, Granier, Claude, Roquet, Francoise, Christie, Michael R., Giordano, Tiziana, Malosio, Maria-Luisa, Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

Zhao, M., Christie, M.R., Heaton, N., George, S., Amiel, S. and Huang, G.C. (2002) Amelioration of streptozotocin-induced diabetes in mice using human islet cells derived from long-term culture in vitro. Transplantation, 73 (9). pp. 1454-1460. ISSN 0041-1337

antibody

Christie, M. R. (1993) Characterization of distinct islet protein auto antigens associated with type 1 diabetes. Autoimmunity, 15 (s1). pp. 1-3. ISSN 0891-6934

antibody blood level

Christie, M. R., Daneman, D., Champagne, P. and Delovitch, T. L. (1990) Persistence of serum antibodies to 64,000-Mr islet cell protein after onset of type I diabetes. Diabetes, 39 (6). pp. 653-656. ISSN 0012-1797

Roll, U., Christie, M. R., Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

antibody detection

Bingley, P. J., Christie, M. R., Bonifacio, E., Bonfanti, R., Shattock, M., Fonte, M.-T., Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Christie, M. R., Daneman, D., Champagne, P. and Delovitch, T. L. (1990) Persistence of serum antibodies to 64,000-Mr islet cell protein after onset of type I diabetes. Diabetes, 39 (6). pp. 653-656. ISSN 0012-1797

Christie, M. R., Genovese, S., Cassidy, D., Bosi, E., Brown, T. J., Lai, M., Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

Christie, M. R., Tun, R. Y. M., Lo, S. S. S., Cassidy, D., Brown, T. J., Hollands, J., Shattock, M., Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Christie, Michael R., Roll, Ursula, Payton, Mark A., Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Damanhouri, L. H., Dromey, J. A., Christie, Michael R., Nasrat, H. A., Ardawi, M. S. M., Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Gylling, Mikhail, Tuomi, Tiinamaija, Bjorses, Petra, Kontiainen, Sirkka, Partanen, Jukka, Christie, Michael R., Knip, Mikael, Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

Morgenthaler, N. G., Löbner, K., Morgenthaler, U. Y., Christie, M. R., Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Roll, U., Christie, M. R., Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797

Wagner, R., McNally, J. M., Bonifacio, E., Genovese, S., Foulis, A., McGill, M., Christie, M. R., Betterle, C., Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797

antibody response

Bingley, P. J., Christie, M. R., Bonifacio, E., Bonfanti, R., Shattock, M., Fonte, M.-T., Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Christie, M. R., Genovese, S., Cassidy, D., Bosi, E., Brown, T. J., Lai, M., Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

antibody specificity

Bingley, P. J., Christie, M. R., Bonifacio, E., Bonfanti, R., Shattock, M., Fonte, M.-T., Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Christie, M. R., Tun, R. Y. M., Lo, S. S. S., Cassidy, D., Brown, T. J., Hollands, J., Shattock, M., Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Christie, M. R., Hollands, J. A., Brown, T. J., Michelsen, B. K. and Delovitch, T. L. (1993) Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. Journal of Clinical Investigation, 92 (1). pp. 240-248. ISSN 0021-9738

antibody titer

Bingley, P. J., Christie, M. R., Bonifacio, E., Bonfanti, R., Shattock, M., Fonte, M.-T., Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Damanhouri, L. H., Dromey, J. A., Christie, Michael R., Nasrat, H. A., Ardawi, M. S. M., Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Roll, U., Christie, M. R., Fuchtenbusch, M., Payton, M. A., Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

antibody, autoimmunity

Bottazzo, G. F., Genovese, S., Bosi, E., Dean, B. M., Christie, M. R. and Bonifacio, E. (1991) Novel considerations on the antibody/autoantigen system in type I (insulin-dependent) diabetes mellitus. Annals of Medicine, 23 (4). pp. 453-461. ISSN 0785-3890

anticancer

Daley, E., Wilkie, D., Loesch, A., Hargreaves, I. P., Kendall, D. A., Pilkington, G. J. and Bates, T. E. (2005) Chlorimipramine: a novel anticancer agent with a mitochondrial target. Biochemical and Biophysical Research Communications, 328 (2). pp. 623-632. ISSN 0006-291X

antidepressants

Daley, E., Wilkie, D., Loesch, A., Hargreaves, I. P., Kendall, D. A., Pilkington, G. J. and Bates, T. E. (2005) Chlorimipramine: a novel anticancer agent with a mitochondrial target. Biochemical and Biophysical Research Communications, 328 (2). pp. 623-632. ISSN 0006-291X

antidiabetic agent

Christie, Michael R., Molvig, Jens, Hawkes, Charlotte J., Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992

antigen

Christie, M. R. (1993) Characterization of distinct islet protein auto antigens associated with type 1 diabetes. Autoimmunity, 15 (s1). pp. 1-3. ISSN 0891-6934

Hawkes, C. J., Wasmeier, C., Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

antigen antibody complex

Hawkes, C. J., Wasmeier, C., Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

antigen antibody reaction

Desai, M.a, Cull, C.A.b, Horton, V.A.a, Christie, M.R.c, Bonifacio, E.d, Lampasona, V.d, Bingley, P.J.e, Levy, J.C.a, Mackay, I.R.f, Zimmet, P.g, Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

antigen binding

Bearzatto, Massimo, Naserke, Heike, Piquer, Sandra, Koczwara, Kerstin, Lampasona, Vito, Williams, Alistair, Christie, Michael R., Bingley, Polly J., Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Christie, M. R., Hollands, J. A., Brown, T. J., Michelsen, B. K. and Delovitch, T. L. (1993) Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. Journal of Clinical Investigation, 92 (1). pp. 240-248. ISSN 0021-9738

Hatfield, E. C. I., Hawkes, C. J., Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Hawkes, C. J., Wasmeier, C., Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Payton, M. A., Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738

Piquer, Sandra, Valera, Lionel, Lampasona, Vito, Jardin-Watelet, Benedicte, Roche, Stephanie, Granier, Claude, Roquet, Francoise, Christie, Michael R., Giordano, Tiziana, Malosio, Maria-Luisa, Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411

antigen detection

Christie, M. R., Hollands, J. A., Brown, T. J., Michelsen, B. K. and Delovitch, T. L. (1993) Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. Journal of Clinical Investigation, 92 (1). pp. 240-248. ISSN 0021-9738

Roll, U., Christie, M. R., Fuchtenbusch, M., Payton, M. A., Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797

antigen expression

Hawkes, C. J., Wasmeier, C., Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

antigen presentation

Bearzatto, Massimo, Naserke, Heike, Piquer, Sandra, Koczwara, Kerstin, Lampasona, Vito, Williams, Alistair, Christie, Michael R., Bingley, Polly J., Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

antigen recognition

Hatfield, E. C. I., Hawkes, C. J., Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

antigen specificity

Bearzatto, Massimo, Naserke, Heike, Piquer, Sandra, Koczwara, Kerstin, Lampasona, Vito, Williams, Alistair, Christie, Michael R., Bingley, Polly J., Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Christie, M. R., Genovese, S., Cassidy, D., Bosi, E., Brown, T. J., Lai, M., Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

Hawkes, C. J., Schloot, N. C., Marks, J., Willemen, S. J. M., Drijfhout, J. W., Mayer, E. K., Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

antisense cDNA

Levicar, Natasa, Dewey, Ricardo A., Daley, Emma, Bates, Timothy E., Davies, Derek, Kos, Janko, Pilkington, Geoffrey J. and Lah, Tamara T. (2003) Selective suppression of cathepsin L by antisense cDNA impairs human brain tumor cell invasion in vitro and promotes apoptosis. Cancer Gene Therapy, 10 (2). pp. 141-51. ISSN 0929-1903

apoptosis

Athanasiou, Andriani, Clarke, Anna B., Turner, Amy E., Kumaran, Nethia M., Vakilpour, Sara, Smith, Paul A., Bagiokou, Dimitra, Bradshaw, Tracey D., Westwell, Andrew D., Fang, Lin, Lobo, Dileep N., Constantinescu, Cris S., Calabrese, Vittorio, Loesch, Andrzej, Alexander, Stephen P. H., Clothier, Richard H., Kendall, David A. and Bates, Timothy E. (2007) Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications, 364 (1). pp. 131-137. ISSN 0006-291x

Athanasiou, Andriani, Smith, Paul A., Vakilpour, Sara, Kumaran, Nethia M., Turner, Amy E., Bagiokou, Dimitra, Layfield, Robert, Ray, David E., Westwell, Andrew D., Alexander, Stephen P. H., Kendall, David A., Lobo, Dileep N., Watson, Susan A., Lophatanon, Artitaya, Muir, Kenneth A., Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X

Daley, E., Wilkie, D., Loesch, A., Hargreaves, I. P., Kendall, D. A., Pilkington, G. J. and Bates, T. E. (2005) Chlorimipramine: a novel anticancer agent with a mitochondrial target. Biochemical and Biophysical Research Communications, 328 (2). pp. 623-632. ISSN 0006-291X

Levicar, Natasa, Dewey, Ricardo A., Daley, Emma, Bates, Timothy E., Davies, Derek, Kos, Janko, Pilkington, Geoffrey J. and Lah, Tamara T. (2003) Selective suppression of cathepsin L by antisense cDNA impairs human brain tumor cell invasion in vitro and promotes apoptosis. Cancer Gene Therapy, 10 (2). pp. 141-51. ISSN 0929-1903

arm-cranking exercise

Klonizakis, Markos (2012) Studying the cutaneous microcirculatory response during upper-limb exercise in healthy, older, sedentary people. Clinical Hemorheology and Microcirculation, 51 (1). pp. 69-75. ISSN 1386-0281

article

Bearzatto, Massimo, Naserke, Heike, Piquer, Sandra, Koczwara, Kerstin, Lampasona, Vito, Williams, Alistair, Christie, Michael R., Bingley, Polly J., Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767

Bingley, P. J., Christie, M. R., Bonifacio, E., Bonfanti, R., Shattock, M., Fonte, M.-T., Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797

Christie, M. R., Daneman, D., Champagne, P. and Delovitch, T. L. (1990) Persistence of serum antibodies to 64,000-Mr islet cell protein after onset of type I diabetes. Diabetes, 39 (6). pp. 653-656. ISSN 0012-1797

Christie, M. R., Genovese, S., Cassidy, D., Bosi, E., Brown, T. J., Lai, M., Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797

Christie, M. R., Tun, R. Y. M., Lo, S. S. S., Cassidy, D., Brown, T. J., Hollands, J., Shattock, M., Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797

Christie, M. R., Vohra, G., Champagne, P., Daneman, D. and Delovitch, T. L. (1990) Distinct antibody specificities to a 64-kD islet cell antigen in Type 1 diabetes as revealed by trypsin treatment. Journal of Experimental Medicine, 172 (3). pp. 789-794. ISSN 0022-1007

Christie, Michael, Brown, T. J. and Cassidy, D. (1992) Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme. Diabetologia, 35 (4). pp. 380-384. ISSN 0012-186X

Christie, Michael, Landin-Olsson, M., Sundkvist, G., Dahlquist, G., Lernmark, A. and Baekkeskov, S. (1988) Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes. Diabetologia, 31 (8). pp. 597-602. ISSN 0012-186X

Christie, Michael R., Roll, Ursula, Payton, Mark A., Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992

Christie, M. R., Hollands, J. A., Brown, T. J., Michelsen, B. K. and Delovitch, T. L. (1993) Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. Journal of Clinical Investigation, 92 (1). pp. 240-248. ISSN 0021-9738

Damanhouri, L. H., Dromey, J. A., Christie, Michael R., Nasrat, H. A., Ardawi, M. S. M., Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

Desai, M.a, Cull, C.A.b, Horton, V.A.a, Christie, M.R.c, Bonifacio, E.d, Lampasona, V.d, Bingley, P.J.e, Levy, J.C.a, Mackay, I.R.f, Zimmet, P.g, Holman, R.R.b and Clark, A.a h (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia, 50 (10). pp. 2052-2060. ISSN 0012186X

Gillespie, Kathleen M., Bain, Steven C., Barnett, Anthony H., Bingley, Polly J., Christie, Michael R., Gill, Geoffrey V. and Gale, Edwin A. M. (2004) The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. The Lancet, 364 (9446). pp. 1699-1700. ISSN 0140-6736

Gorus, F. K., Goubert, P., Semakula, C., Vandewalle, C. L., De Schepper, J., Scheen, A., Christie, Michael R. and Pipeleers, D. G. (1997) IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia, 40 (1). pp. 95-99. ISSN 0012-186X

Gylling, Mikhail, Tuomi, Tiinamaija, Bjorses, Petra, Kontiainen, Sirkka, Partanen, Jukka, Christie, Michael R., Knip, Mikael, Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X

Hatfield, E. C. I., Hawkes, C. J., Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X

Hawa, M., Rowe, R., Lan, M. S., Notkins, A. L., Pozzilli, P., Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797

Hawkes, C. J., Wasmeier, C., Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797

Hawkes, C. J., Schloot, N. C., Marks, J., Willemen, S. J. M., Drijfhout, J. W., Mayer, E. K., Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797

Huang, Guo Cai, Zhao, Min, Jones, Peter, Persaud, Shanta, Ramracheya, Reshma, Lobner, Kristian, Christie, Michael R., Banga, J. Paul, Peakman, Mark, Sirinivsan, Parthi, Rela, Mohammed, Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337

Lampeter, E. F., Kolb, H., Seifert, I., Lohmann, D., Heise, J. W., Bertrams, J., Christie, Michael and Kolb-Bachofen, V. (1994) Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity. Diabetologia, 37 (5). pp. 471-475. ISSN 0012-186X

Morgenthaler, N. G., Löbner, K., Morgenthaler, U. Y., Christie, M. R., Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043

Morgenthaler, N. G., Seissler, J., Achenbach, P., Glawe, D., Payton, M., Meinck, H.-M., Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934

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