A

Abou-Ismail, Usama and Burman, Oliver and Nicol, Christine and Mendl, Michael (2008) Let sleeping rats lie: does the timing of husbandry procedures affect laboratory rat behaviour, physiology and welfare? Applied Animal Behaviour Science, 111 (3-4). pp. 329-341. ISSN 0168-1591

Adetutu, E. M. and Ball, A. S. and Osborn, A. M. (2008) Azoxystrobin and soil interactions: degradation and impact on soil bacterial and fungal communities. Journal of Applied Microbiology, 105 (6). pp. 1777-1790. ISSN 1364 5072

Ampatzioglou, Eirini and Karatasios, Ioannis and Colston, Belinda and Watt, David and Kilikoglou, Vassilis (2008) The effect of natural pozzolans in conservation mortars. In: 5th Symposium of the Hellenic Society of Archaeometry, 8–10 October 2008, Athens, Greece.

B

Bachrati, Csanad Z. and Hickson, Ian D. (2008) RecQ helicases: guardian angels of the DNA replication fork. Chromosoma, 117 (3). pp. 219-233. ISSN 0009-5915

Barnes, Katherine and Gennard, Dorothy and Dixon, Ron (2008) Differences in the antibacterial activity of Lucilia sericata (M) larval excretion/secretion compared to Calliphora vicina (R-D), Tenebrio molitor (l) and Dermestes maculatus (D). In: 108th American Society of Microbiology (ASM) General Meeting, 1st - 5th June 2008, Boston, USA.

Baron, Mark and Elie, Mathieu (2008) Enhancement of microcrystalline identification of gamma-hydroxybutyrate. Journal of Forensic Science, 53 (1). pp. 147-150. ISSN 0022-1198

Biswas, Subhajit and Field, Hugh J. (2008) Herpes simplex virus helicase-primase inhibitors: recent findings from the study of drug resistance mutations. Antiviral Chemistry & Chemotherapy, 19 (1). pp. 1-6. ISSN 0956-3202

Biswas, Subhajit and Kleymann, Gerald and Swift, Mihaiela and Tiley, Laurence S. and Lyall, Jonathan and Aguirre-Hernández, Jesús and Field, Hugh J. (2008) A single drug-resistance mutation in HSV-1 UL52 primase points to a difference between two helicase-primase inhibitors in their mode of interaction with the antiviral target. Journal of Antimicrobial Chemotherapy, 61 (5). pp. 1044-1047. ISSN 0305-7453

Biswas, Subhajit and Tiley, Laurence S. and Zimmermann, Holger and Birkmann, Alexander and Field, Hugh J. (2008) Mutations close to functional motif IV in HSV-1 UL5 helicase that confer resistance to HSV helicase-primase inhibitors, variously affect virus growth rate and pathogenicity. Antiviral Research, 80 (1). pp. 81-85. ISSN 0166-3542

Braem, Maya and Mills, Daniel and Doherr, Marcus and Lehmann, Doris and Steiger, Andreas (2008) Evaluating aggressive behavior in dogs: a comparison of 3 tests. Journal of Veterinary Behavior- Clinical Applications and Research, 3 (4). pp. 152-160. ISSN UNSPECIFIED

Brooks, Keith J. and Hargreaves, Iain P. and Bates, Timothy E. (2008) Protection of respiratory chain enzymes from ischaemic damage in adult rat brain slices. Neurochemical research, 33 (9). pp. 1711-1716. ISSN 0364-3190

Bruce, Toby J. A. and Matthes, Michaela C. and Chamberlain, Keith and Woodcock, Christine M. and Mohib, Abdul and Webster, Ben and Smart, Lesley E. and Birkett, Michael A. and Pickett, John A. and Napier, Johnathan A. (2008) Cis-jasmone induces Arabidopsis genes that affect the chemical ecology of multitrophic interactions with aphids and their parasitoids. Proceedings of the National Academy of Sciences of the United States of America, 105 (12). pp. 4553-4558. ISSN 0027-8424

Burman, Oliver and Owen, Diane and Abou-Ismail, Usama and Mendl, Michael (2008) Removing individual rats affects indicators of welfare in the remaining group members. Physiology & Behavior, 93 (1-2). pp. 89-96. ISSN 0031-9384

Burman, Oliver and Parker, Richard and Paul, Elizabeth and Mendl, Michael (2008) Sensitivity to reward loss as an indicator of animal emotion and welfare. Biology Letters, 4 (4). pp. 330-333. ISSN 1744-9561

Burman, Oliver and Parker, Richard and Paul, Elizabeth and Mendl, Mike (2008) A spatial judgement task to determine background emotional state in laboratory rats (Rattus norvegicus). Animal Behaviour, 76 (3). pp. 801-809. ISSN 0003-3472

C

Calabrese, Vittorio and Bates, Timothy E. and Mancuso, Cesare and Cornelius, Carolin and Ventimiglia, Bernardo and Cambria, Maria Teresa and Di Renzo, Laura and De Lorenzo, Antonino and Dinkova-Kostova, Albena T. (2008) Curcumin and the cellular stress response in free radical-related diseases. Molecular Nutrition & Food Research, 52 (9). pp. 1062-1073. ISSN 1613-4125

Calabrese, Vittorio and Cornelius, Carolin and Mancuso, Cesare and Pennisi, Giovanni and Calafato, Stella and Bellia, Francesco and Bates, Timothy E. and Giuffrida Stella, Anna Maria and Schapira, Tony and Dinkova Kostova, Albena T. and Rizzarelli, Enrico (2008) Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity. Neurochemical Research, 33 (12). pp. 2444-2471. ISSN 0364-3190

Coates, Michael I. and Ruta, Marcello and Friedman, Matt (2008) Ever since Owen: changing perspectives on the early evolution of tetrapods. Annual Review of Ecology, Evolution, and Systematics, 39 . pp. 571-592. ISSN 1543-592X

Colston, Belinda and Watt, David (2008) Non-destructive investigation of a historic English lighthouse. In: 1st International Conference on Construction Heritage in Coastal and Marine Environments: damage, diagnostics, maintenance and rehabilitation, 28–30 January 2008, Lisbon, Portugal.

Connell , Emma and Giniatullina, Asiya and Lai-Kee-Him, Joséphine and Tavare, Richard and Ferrari, Enrico and Roseman, Alan and Cojoc, Dan and Brisson, Alain R. and Davletov, Bazbek (2008) Cross-linking of phospholipid membranes is a conserved property of calcium-sensitive synaptotagmins. Journal of molecular biology, 380 (1). pp. 42-50. ISSN 0022-2836

Cracknell, Nina R. and Mills, Daniel S. (2008) A double-blind placebo-controlled study into the efficacy of a homeopathic remedy for fear of firework noises in the dog (Canis familiaris). The Veterinary Journal, 177 (1). pp. 80-88. ISSN 1090-0233

Cracknell, Nina Rachel and Mills, Daniel Simon and Kaulfuss, Patricia (2008) Can stimulus enhancement explain the apparent success of the model-rival technique in the domestic dog (Canis familiaris)? Applied Animal Behaviour Science, 114 (3-4). pp. 461-472. ISSN 0168-1591

Cracknell, Nina and Mills, Daniel (2008) A double-blind placebo-controlled study into the efficacy of a homeopathic remedy for fear of firework noises in the dog (Canis familiaris). Veterinary Journal, 177 . pp. 80-88. ISSN 1090-0233

D

Daramola, Bukola and Dixon, Ron and Williams, D. R. (2008) Antibiotic susceptibility of Vibrio parahaemolyticus: a surveillance study. In: American Society of Microbiology conference on antimicrobial resistance in zoonotic bacteria and foodborne pathogens, 15th - 18th June 2008, Copenhagen, Denmark.

Daramola, Bukola and Williams, D. R. and Dixon, Ron (2008) Improved detection of environmental Vibrio parahaemolyticus through the use of chromogenic media. In: Society for General Microbiology Meeting, 31st March - 3rd April 2008, Edinburgh.

Daramola, Bukola and Williams, D. R. and Dixon, Ron (2008) A survey of the prevalence of Vibrio parahaemolyticus in the River Humber on the East Coast of England. In: 108th American Society of Microbiology (ASM) General Meeting, 1st - 5th June 2008, Boston, USA.

Deeming, Charles (2008) Avian brood patch temperature: relationships with female body size, incubation period, developmental maturity and phylogeny. Journal of Thermal Biology, 33 (6). pp. 345-354. ISSN 0306-4565

Deeming, Charles (2008) Capture of smooth newts (Lissotriton vulgaris) and great crested newts (Triturus cristatus) correlates with the lunar cycle. The Herpetological Journal, 18 (3). pp. 171-174. ISSN 0268-0130

Deeming, Charles (2008) Egg size and embryonic growth: a hypothesis. Avian Biology Research, 1 (3). pp. 124-125. ISSN 1758-1559

Deeming, Charles and du Feu, Christopher R. (2008) Measurement of brood patch temperature of British passerines using an infrared thermometer. Bird Study, 55 (1). pp. 139-143. ISSN 0006-3657

Dicker, Emma and Deeming, Charles (2008) Effect of egg size on growth of extra-embryonic membranes. British Poultry Abstracts, 4 (1). pp. 18-19. ISSN 1746-6202

Dixon, Ron (2008) Outer membrane protein analysis of ampicillin-resistant isolates of Haemophilus influenzae from Saudi Arabia. Journal of Infection and Public Health, 1 (1). pp. 45-50. ISSN UNSPECIFIED

Dixon, Ron and Sahalan, Ahmad Z. (2008) Role of the cell envelope in the antibacterial activities of polymyxin B and polymyxin B nonapeptide against Escherichia coli. International Journal of Antimicrobial Agents , 31 (3). pp. 224-227. ISSN 0924-8579

Dixon, Ron and Summerfield , S. and Shaw, M. (2008) Microbes in amber: ancient colonists or modern infiltrates. In: 9th international conference on ancient DNA , 19th - 22nd October 2008, Pompeii, Italy.

Dixon, Ron and Dawson, Lucy and Taylor, Delia (2008) The experimental degradation of archaeological human bone by anaerobic bacteria and the implications for recovery of ancient DNA. In: The 9th International Conference on Ancient DNA and Associated Biomolecules, 19-22 October 2008, Pompeii, Italy.

Downey, Hilary and Ellis, Sarah (2008) Tails of animal attraction: incorporating the feline into the family. Journal of Business Research, 61 (5). pp. 434-441. ISSN 0148-2963

E

Ellis, Sarah and Wells, Deborah (2008) The influence of visual stimulation on the behaviour of cats housed in a rescue shelter. Applied Animal Behaviour Science, 113 (1). pp. 166-174. ISSN 0168-1591

F

Fagbemi, Shamusi and Pfeffer, Karen (2008) The use of a driving simulator to study eyewitness accuracy for three different types of collision. Advances in Transportation Studies: An International Journal (Specia). pp. 43-54. ISSN 1824-5463

G

Garbin , Valeria and Volpe, Giovanni and Ferrari, Enrico and Kozyreff, Gregory and Versluis, Michel and Petrov, Dmitri and Cojoc, Dan (2008) Mie scattering of a Laguerre-Gaussian beam for position detection of microbubbles. In: Lasers and Electro-Optics, 2008 and 2008 Conference on Quantum Electronics and Laser Science. CLEO/QELS 2008, 4-9 May 2008, San Jose, CA.

Goddard, Alan D. and Moir, James W. B. and Richarson, David J. and Ferguson, Stuart J. (2008) Interdependence of two NarK domains in a fused nitrate/nitrite transporter. Molecular Microbiology, 70 (3). pp. 667-681. ISSN 0950-382X

Goodman, A. M. and Haggis , L. (2008) Regional variation in the flexural properties of the equine hoof wall. Comparative Exercise Physiology , 5 . 161-168.. ISSN 1755-2540

Graham, Robert Leslie James and Graham, Ciaren and Theakson, David and McMullan, Geoff and Shaw , Chris (2008) Elucidation of trends within venom components from the snake families Elapidae and Viperidae using gel filtration chromatography. Toxicon, 51 (1). pp. 121-129. ISSN 0041-0101

Gutierrez, Humberto and O'Keeffe, Gerard W and Gavaldà, Núria and Gallagher, Denis and Davies, Alun M (2008) Nuclear factor kappa B signaling either stimulates or inhibits neurite growth depending on the phosphorylation status of p65/RelA. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 28 (33). pp. 8246-8256. ISSN UNSPECIFIED

H

Hall, Stephen (2008) A comparative analysis of the habitat of the extinct aurochs and other prehistoric mammals in Britain. Ecography, 31 (2). pp. 187-190. ISSN 0906-7590

Hall, Stephen (2008) A comparative analysis of the habitat of the extinct aurochs and other prehistoric mammals in Britain. Ecography - Pattern & Diversity in Ecology, 31 (2). pp. 187-190. ISSN UNSPECIFIED

I

Iossa, Graziella and Soulsbury, Carl and Baker, Philip and Harris, Stephen (2008) Body mass, territory size and life-history tactics in a socially monogamous canid, the red fox Vulpes vulpes. Journal of Mammalogy, 89 (6). pp. 1481-1490. ISSN 0022-2372

Iossa, Graziella and Soulsbury, Carl D. and Baker, Philip J. and Harris, Stephen (2008) Sperm competition and the evolution of testes size in terrestrial mammalian carnivores. Functional Ecology, 22 (4). pp. 655-662. ISSN 0269-8463

J

Jones, Trevor and Lawson, Shaun and Mills, Daniel (2008) Interaction with a zoomorphic robot that exhibits canid mechanisms of behaviour. In: Robotics and Automation, 2008. ICRA 2008. IEEE International Conference on, 19 - 23 May 2008, Pasadena, CA.

K

Karatasios, Ioannis and Kilikoglou, Vassilis and Theoulakis, Panagiotis and Colston, Belinda and Watt, David (2008) A new approach to conservation mortars designed for the urban environment. In: Conservation Science 2007. Archetype, London, pp. 289-290. ISBN 9781904982340

Karatasios, Ioannis and Kilikoglou, Vassilis and Thlakis, Panagiotis and Colston, Belinda and Watt, David (2008) Sulphate resistance of lime-based barium mortars. Cement and Concrete Composites, 30 (9). pp. 815-821. ISSN 0958-9465

L

Lancaster, Lorna and Savelsbergh, Andreas and Kleanthous, Colin and Wintermeyer, Wolfgang and Rodnina, Marina (2008) Colicin E3 cleavage of 16S rRNA impairs decoding and accelerates tRNA translocation on Escherichia coli ribosomes. Molecular Microbiology, 69 (2). pp. 390-401. ISSN 0950-382X

Levine, E. D. and Mills, D. S. (2008) Long-term follow-up of the efficacy of a behavioural treatment programme for dogs with firework fears. The Veterinary Record, 162 (20). pp. 657-659. ISSN 0042-4900

M

McCune, Sandra and Stevenson, Joy and Fretwell, Laura and Thompson, Amy and Mills, Daniel (2008) Ageing does not significantly affect performance in a spatial learning task in the domestic cat (Felis silvestris catus). Applied Animal Behaviour Science, 112 (3-4). pp. 345-356. ISSN 0168-1591

McLachlan, Athol and Pike, Thomas and Thomason, Jeremy (2008) Another kind of symmetry: are there adaptive benefits to the arrangement of mites on an insect host? Ethology, Ecology and Evolution, 20 (3). pp. 257-270. ISSN 0394-9370

Mills, Daniel (2008) Horse welfare. AWIC Bulletin, 13 (3). pp. 5-7. ISSN 1522-7553

Mills, Daniel S. (2008) Recognising the nature of problem behaviour. The Veterinary Journal, 176 (2). pp. 127-128. ISSN 1090-0233 (In Press)

Mohapatra, Jajati K. and Sanyal, Aniket and Hemadri, Divakar and Tosh, Chakradhar and Biswas, Subhajit and Knowles, Nick J. and Rasool, Thaha J. and Bandyopadhyay, Santanu K. and Pattnaik, Bramhadev (2008) Comparative genomics of serotype Asia 1 foot-and-mouth disease virus isolates from India sampled over the last two decades. Virus Research, 136 (1-2). pp. 16-29. ISSN 0168-1702

Mworia, John K. and Kinyamario, Jenesio I. and John, Elizabeth A. (2008) Impact of the invader Ipomoea hildebandtii on grass biomass, nitrogen mineralisation and determinants of its seedling establishment in Kajiado, Kenya. African Journal of Range and Forage Science , 25 (1). pp. 11-16. ISSN 1022-0119

Myburgh, J. G. and Botha, C. J. and Booyse, D. G. and Reyers, Fred (2008) Provisional clinical chemistry parameters in the African sharptooth catfish (Clarias gariepinus). Journal of the South African Veterinary Association, 79 (4). pp. 156-160. ISSN 1019-9128

O

O'Keeffe, Gerard W. and Gutierrez, Humberto and Pandolfi, Pier Paolo and Riccardi, Carlo and Davies, Alun M. (2008) NGF-promoted axon growth and target innervation requires GITRL-GITR signaling. Nature Neuroscience, 11 (2). pp. 135-42. ISSN 1097-6256

P

Pike, Thomas W. and Samanta, Madhumita and Lindström, Jan and Royle, Nick J. (2008) Behavioural phenotype affects social interactions in an animal network. Proceedings of the Royal Society B, 275 (1650). pp. 2515-2520. ISSN 0962-8452

Pincheira-Donoso, Daniel (2008) Testing the accuracy of fecal-based analyses in studies of trophic ecology in lizards. Copeia (2). pp. 322-325. ISSN 0045-8511

Pincheira-Donoso, Daniel and Hodgson, David J. and Tregenza, Tom (2008) Comparative evidence for strong phylogenetic inertia in precloacal signalling glands in a species-rich lizard clade. Evolutionary Ecology Research, 10 (1). pp. 11-28. ISSN 1522-0613

Pincheira-Donoso, Daniel and Hodgson, David J. and Tregenza, Tom (2008) The evolution of body size under environmental gradients in ectotherms: why should Bergmann's rule apply to lizards? BMC Evolutionary Biology, 8 (1). p. 68. ISSN 1471-2148

Pincheira-Donoso, Daniel and Scolaro, J. Alejandro and Sura, Piotra (2008) A monographic catalogue on the systematics and phylogeny of the South American iguanian lizard family Liolaemidae (Squamata, Iguania). Zootaxa (1800). pp. 1-85. ISSN 1175-5326

Popuri, Venkateswarlu and Bachrati, Csanad Z. and Muzzolini, Laura and Mosedale, Georgina and Costantini, Silvia and Giacomini, Elisa and Hickson, Ian D. and Vindigni, Alessandro (2008) The Human RecQ helicases, BLM and RECQ1, display distinct DNA substrate specificities. The Journal of biological chemistry, 283 (26). pp. 17766-17776. ISSN 0021-9258

Purewal, V. and Colston, B. and Röhrs, S. (2008) Developing a simple screening method for the identification of historic biocide residues on herbarium material in museum collections. X-ray Spectrometry, 37 (2). pp. 137-141. ISSN 0049-8246

R

Rugman-Jones, Paul F. and Eady, Paul E. (2008) Co-evolution of male and female reproductive traits across the Bruchidae (Coleoptera). Functional Ecology, 22 (5). pp. 880-886. ISSN 0269-8463

Ruta, Marcello and Benton, Michael J. (2008) Calibrated diversity, tree topology and the mother of mass extinctions: the lesson of temnospondyls. Palaeontology, 51 (6). pp. 1261-1288. ISSN 0031-0239

Ruta, Marcello and Bolt, John R. (2008) The brachyopoid Hadrokkosaurus bradyi from the early Middle Triassic of Arizona, and a phylogenetic analysis of lower jaw characters in temnospondyl amphibians. Acta Palaeontologica Polonica, 53 (4). pp. 579-592. ISSN 0567-7920

S

Scolaro, Jose Alejandro and Ibarguengoytia, Nora Ruth and Pincheira-Donoso, Daniel (2008) When starvation challenges the tradition of niche conservatism: on a new species of the saxicolous genus Phymaturus from Patagonia Argentina with pseudoarboreal foraging behaviour (Iguania, Liolaemidae). Zootaxa (1786). pp. 48-60. ISSN 1175-5326

Selak, Nives and Bachrati, Csanad Z. and Shevelev, Igor and Dietschy, Tobias and van Loon, Barbara and Jacob, Anette and Hübscher, Ulrich and Hoheisel, Joerg D. and Hickson, Ian D. and Stagljar, Igor (2008) The Bloom's syndrome helicase (BLM) interacts physically and functionally with p12, the smallest subunit of human DNA polymerase delta. Nucleic acids research, 36 (16). pp. 5166-5179. ISSN 0305-1048

Sharma, Pallavi and Griffiths, Nicholas and Moses, John E. (2008) Biomimetic synthesis and structural revision of tridachiahydropyrone. Organic Letters, 10 (18). pp. 4025-4027. ISSN 1523-7060

Sherman, Barbara L. and Mills, Daniel S. (2008) Canine anxieties and phobias: an update on separation anxiety and noise aversions. Veterinary Clinics of North America - Small Animal Practice, 38 (5). pp. 1081-1106. ISSN 0195-5616

Sobeih, Karina L. and Baron, Mark and Gonzalez-Rodriguez, Jose (2008) Recent trends and developments in pyrolysis-gas chromatography: review. Journal of Chromatography A, 1186 (1-2). pp. 51-66. ISSN 0021-9673

Soulsbury, Carl D. and Baker, Philip J. and Iossa, Graziella and Harris, Stephen (2008) Fitness costs of dispersal in red foxes (Vulpes vulpes). Behavioral Ecology and Sociobiology, 62 (8). pp. 1289-1298. ISSN 0340-5443

Soulsbury, Carl D. and Iossa, Graziella and Baker, Philip J. and Harris, Stephen (2008) Environmental variation at the onset of independent foraging affects full-grown body mass in the red fox. Proceedings of the Royal Society, London B, 275 (1649). pp. 2411-2418. ISSN 0962-8452

T

Thomas, A. E. and Williams, D. R. and Watts, T. and Hepburn, N. C . and Dixon, Ron (2008) Investigation into the changing colonisation of skin bacteria during isotretinoin treatment for acne vulgaris. In: Society for General Microbiology Meeting, 31st March - 3rd April 2008, Edinburgh.

Thomas, Angela E. and Williams , D. Ross and Watts , Toni and Hepburn , Neil C. and Dixon , Ron A. (2008) Investigation of the changing colonisation of skin bacteria during isotretinoin treatment for Acne vulgaris. In: Meeting - Society for General Microbiology, 31 March to 01 April 2008, Edinburgh.

U

Unwin, David and Deeming, Charles (2008) Pterosaur eggshell structure and its implications for pterosaur reproductive biology. Zitteliana: an international journal of palaeontology and geobiology, B28 . pp. 199-207. ISSN 1612-412X, 1612-4138

V

Vinke, Claudia M. and Hansen, Steffen W. and Mononen, Jaakko and Korhonen, Hannu and Cooper, Jonathan J. and Mohaibes, Maarit and Bakken, Morten and Spruijt, Berry M. (2008) To swim or not to swim: an interpretation of farmed mink's motivation for a water bath. Applied Animal Behaviour Science, 111 (1-2). pp. 1-27. ISSN 0168-1591

Vizard, Thomas N. and O'Keeffe, Gerard W. and Gutierrez, Humberto and Kos, Claudine H. and Riccardi, Daniela and Davies, Alun M. (2008) Regulation of axonal and dendritic growth by the extracellular calcium-sensing receptor. Nature Neuroscience, 11 (3). pp. 285-291. ISSN 1097-6256

W

Webster, Ben and Bruce, Toby and Dufour, Samuel and Birkemeyer, Claudia and Birkett, Mike and Hardie, Jim and Pickett, John (2008) Identification of volatile compounds used in host location by the black bean aphid, Aphis fabae. Journal of Chemical Ecology, 34 (9). pp. 1153-1161. ISSN 0098-0331

Webster, Ben and Bruce, Toby and Pickett, John and Hardie, Jim (2008) Olfactory recognition of host plants in the absence of host-specific volatile compounds. Communicative and Integrative Biology, 1 (2). pp. 167-169. ISSN 1942-0889

Wright, Hannah and Mills, Daniel and Pollux, Petra (2008) Behavioural impulsivity in the domestic dog. In: Canine Science Forum, 5th-9th July 2008, Budapest, Hungary.

X

Xu, Dongyi and Guo, Rong and Sobeck, Alexandra and Bachrati, Csanad Z. and Yang, Jay and Enomoto, Takemi and Brown, Grant W and Hoatlin, Maureen E and Hickson, Ian D and Wang, Weidong (2008) RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability. Genes & development, 22 (20). pp. 2843-2855. ISSN 0890-9369