Items where Creator is "Lear, Martin"

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Number of items: 78.

2019

Lear, Martin, Hirai, Keiichiro, Ogawa, Kouki, Yamashita, Shinji and Hirama, Masahiro (2019) A Convergent Total Synthesis of the Kedarcidin Chromophore: 20-Years in the Making. Journal of Antibiotics, 72 (6). pp. 350-363. ISSN 0021-8820

2018

Li, Jing, Lear, Martin and Hayashi, Yujiro (2018) Autoinductive Conversion of alpha,alpha-Diiodonitroalkanes to Amides and Esters Catalysed by Iodine Byproducts under O2. Chemical Communications, 49 . pp. 6360-6363. ISSN 1359-7345

Lear, Martin (2018) Atypical Oxidative Methods to (A)Typically Activated Esters. In: University College London (UCL)-Tohoku University UK-Japan Organic Symposium, 12 March 2018, Aoba Science Hall, Tohoku University, Japan.

2017

Lear, Martin (2017) The total synthesis of the kedarcidin chromophore: A 20-year Odyssey. In: Gregynog Synthesis Workshop 2017, 13-15 September 2017, Gregynog Hall, Wales, UK.

Lear, Martin (2017) Total Synthesis of Complex & Unstable Nine-membered Enediynes. In: Lecture Tour, January 2017, Osaka Prefecture University, Osaka Institute of Technology, Sophia University, 8-22 January 2016, Japan.

2016

Li, Jing, Lear, Martin and Hayashi, Yujiro (2016) Sterically demanding oxidative amidation of alpha-substituted malononitriles with amines using O2. Angewandte Chemie International Edition, 128 (31). pp. 9060-9064. ISSN 1433-7851

Lear, Martin (2016) The 5-minute interview. Lincolnshire Echo.

Li, Jing, Lear, Martin, Kwon, Eunsang and Hayashi, Yujiro (2016) Mechanism of oxidative amidation of nitroalkanes with oxygen and amine nucleophiles using electrophilic iodine. Chemistry - A European Journal, 22 (16). pp. 5538-5542. ISSN 0947-6539

Lear, Martin (2016) Synthetic ventures into the furanocembranes: bielschowskysin and beyond. In: Lecture Tour, January 2016, Tokyo University, Tohoku University, Kyushu University, 5-22 January 2016, Japan.

2015

Li, Jing, Lear, Martin, Kawamoto, Yuya, Umemiya, Shigenobu, Wong, Alice, Kwon, Eunsang and Hayashi, Yujiro (2015) Oxidative amidation of nitroalkanes with amine nucleophiles using molecular oxygen and iodine. Angewandte Chemie International Edition, 54 (44). pp. 12986-12990. ISSN 1433-7851

Lear, Martin (2015) Routes to nine-membered enediynes: not such a walk in the park. In: 64th Gordon Research Conference (GRC) on Natural Products 2015, July 26-31, 2015, Proctor Academy, Andover, NH, USA.

Hayashi, Yujiro, Shomura, Hiroki, Xu, Qianqian, Lear, Martin and Sato, Itaru (2015) Asymmetric aldol reaction of α,α-disubstituted acetaldehydes catalyzed by Ddphenylprolinol silyl ether for the construction of quaternary stereogenic centers. European Journal of Organic Chemistry, 20 . pp. 4316-4319. ISSN 1434-193X

US20150148262 A1 (2015) Microparticle assembly. .

Pasari, Sandip, Ismail, Shareef M., Wenk, Markus R. and Lear, Martin (2015) Preparation of azide biosynthetic surrogates of myo-Inositol. Tetrahedron Letters, 56 (20). pp. 2597-2601. ISSN 0040-4039

2014

Yamada, Kei, Lear, Martin J., Yamaguchi, Takaya, Yamashita, Shuji, Gridnev, Ilya D., Hayashi, Yujiro and Hirama, Masahiro (2014) Biomimetic total synthesis of cyanosporaside aglycons from a single enediyne precursor through site-selective p-benzyne hydrochlorination. Angewandte Chemie International Edition, 53 (50). pp. 13902-13906. ISSN 1433-7851

Yamada, Kei, Lear, Martin J., Yamaguchi, Takaya, Yamashita, Shuji, Gridnev, Ilya D., Hayashi, Yujiro and Hirama, Masahiro (2014) Biomimetic total synthesis of cyanosporaside aglycons from a single enediyne precursor through site-selectivep-benzyne hydrochlorination. Angewandte Chemie International Edition, 53 (50). pp. 13902-13906. ISSN 1433-7851

Loh, Cheryl C. Y., Suwanarusk, Rossarin, Lee, Yan Quan, Chan, Kitti W. K., Choy, Kit-Ying, Rénia, Laurent, Russell, Bruce, Lear, Martin J., Nosten, François H., Tan, Kevin S. W., Chow, Larry M. C. and Snounou, Georges (2014) Characterization of the commercially-available fluorescent chloroquine-BODIPY conjugate, LynxTag-CQGREEN, as a marker for chloroquine resistance and uptake in a 96-well plate assay. PLoS ONE, 9 (10). e110800. ISSN 1932-6203

Lear, Martin, Hirai, Keiichiro, Yamada, Kei, Takahashi, Ryo and Hirama, Masahiro (2014) Total synthesis and biomimetic studies of nine-membered enediynes. In: CRC International Symposium: Synthesis and Applications of Functional Molecules and Materials Utilizing Biomolecules as a Motif, September 30, 2014, Catalytic Research Center, Hokkaido University, Japan.

Eey, Stanley T.-C. and Lear, Martin J. (2014) Total synthesis of (−)-platensimycin by advancing oxocarbenium- and iminium-mediated catalytic methods. Chemistry - A European Journal, 20 (36). pp. 11556-11573. ISSN 0947-6539

Brennecke, Johannes, Ochs, Christopher J., Boudhar, Aïcha, Reux, Bastien, Subramanian, Gomathy Sandhya, Lear, Martin J., Trau, Dieter and Hobley, Jonathan (2014) Design, preparation and assessment of surface-immobilised tetraphenylethenes for biosensing applications. Applied Surface Science, 307 . pp. 475-481. ISSN 0169-4332

Kotturi, Santosh R., Somanadhan, Brinda, Ch’ng, Jun-Hong, Tan, Kevin S.-W., Butler, Mark S. and Lear, Martin J. (2014) Diverted total synthesis of falcitidin acyl tetrapeptides as new antimalarial leads. Tetrahedron Letters, 55 (11). pp. 1949-1951. ISSN 0040-4039

Lam, S. M., Tong, L., Reux, B., Duan, X., Petznick, A., Yong, S. S., Khee, C. B. S., Lear, M. J., Wenk, M. R. and Shui, G. (2014) Lipidomic analysis of human tear fluid reveals structure-specific lipid alterations in dry eye syndrome. The Journal of Lipid Research, 55 (2). pp. 299-306. ISSN 0022-2275

2013

Lear, Martin J. and Hayashi, Yujiro (2013) Remote 1,6-stereocontrol by iminium-mediated organocatalytic events. ChemCatChem, 5 (12). pp. 3499-3501. ISSN 1867-3880

National University of Singapore (2013) A microparticle assembly. WO2013176625 A1.

Lam, Sin Man, Tong, Louis, Reux, Bastien, Lear, Martin J., Wenk, Markus R. and Shui, Guanghou (2013) Rapid and sensitive profiling of tear wax ester species using high performance liquid chromatography coupled with tandem mass spectrometry. Journal of Chromatography A, 1308 . pp. 166-171. ISSN 0021-9673

Yang, Eugene G., Sekar, Karthik and Lear, Martin J. (2013) A macrolactonisation approach to the cembrane carbocycle of bielschowskysin. Tetrahedron Letters, 54 (33). pp. 4406-4408. ISSN 0040-4039

Lear, Martin (2013) Synthetic ventures into the platensimycins, bielschowskysins, lipstatins, and enediynes. In: Lecture Tour, July 2013, RIKEN, Waseda University, Keio University, Sophia University, Japan.

Somanadhan, Brinda, Kotturi, Santosh R., Yan Leong, Chung, Glover, Robert P., Huang, Yicun, Flotow, Horst, Buss, Antony D., Lear, Martin J. and Butler, Mark S. (2013) Isolation and synthesis of falcitidin, a novel myxobacterial-derived acyltetrapeptide with activity against the malaria target falcipain-2. The Journal of Antibiotics, 66 (5). pp. 259-264. ISSN 0021-8820

Siebenhofer, Bernhard, Gorelik, Sergey, Lear, Martin J., Song, Hong Yan, Nowak, Christoph and Hobley, Jonathan (2013) Transient absorption spectroscopy on spiropyran monolayers using nanosecond pump–probe Brewster angle reflectometry. Photochemical & Photobiological Sciences, 12 (5). pp. 848-853. ISSN 1474-905X

Ch'ng, Jun-Hong, Mok, Sachel, Bozdech, Zbynek, Lear, Martin James, Boudhar, Aicha, Russell, Bruce, Nosten, Francois and Tan, Kevin Shyong-Wei (2013) A whole cell pathway screen reveals seven novel chemosensitizers to combat chloroquine resistant malaria. Scientific Reports, 3 (1734). ISSN 2045-2322

Song, Hongyan, Gorelik, Sergey, Hobley, Jonathan, Li, Jiexun, Boudhar, AÏcha and Lear, Martin J. (2013) Pyrene emission from monolayers 'clicked' onto quartz. Journal of Molecular and Engineering Materials, 01 (01). pp. 1250007-1. ISSN 2251-2373

2012

Yang, Peng-Yu, Wang, Min, Liu, Kai, Ngai, Mun Hong, Sheriff, Omar, Lear, Martin J., Sze, Siu Kwan, He, Cynthia Y. and Yao, Shao Q. (2012) Parasite-based screening and proteome profiling reveal orlistat, an FDA-approved drug, as a potential anti trypanosoma brucei agent. Chemistry - A European Journal, 18 (27). pp. 8403-8413. ISSN 0947-6539

Ghosh, Shibaji K., Butler, Mark S. and Lear, Martin J. (2012) Synthesis of 2-C-methylerythritols and 2-C-methylthreitols via enantiodivergent Sharpless dihydroxylation of trisubstituted olefins. Tetrahedron Letters, 53 (22). pp. 2706-2708. ISSN 0040-4039

Lear, Martin (2012) Total synthesis and drug pursuits: the good, the bad, and the ugly. In: UK and European Lecture Tour, May - July 2012, St Andrews, Edinburgh, and Glasgow Universities (UK), EPFL (Lausanne, Switzerland), University of Strasbourg (France).

National University of Singapore (2012) Synthesis and use of fluorophore-tagged antimalarials. US20120100555 A1.

Ghosh, Shibaji K., Somanadhan, Brinda, Tan, Kevin S.-W., Butler, Mark S. and Lear, Martin J. (2012) Absolute configuration and total synthesis of a novel antimalarial lipopeptide by the de novo preparation of chiral nonproteinogenic amino acids. Organic Letters, 14 (6). pp. 1560-1563. ISSN 1523-7060

Lear, Martin (2012) Total synthesis and drug pursuits: laetirobins, lipstatins, platensimycins. In: ZiNG Natural Products Conference 2012: Natural Products Synthesis and Biosynthesis, 10 - 13 February 2012, Lanzarote, Spain.

Tejasvi, Amrita, Lear, Martin and Tan, Kevin (2012) Enhancing malaria research. Project Report. CyberMedia.

Lear, Martin, Reux, Bastien and Sekar, Karthik (2012) Chemical synthesis, modification and mimicry of the GPI anchor. In: GPI membrane anchors: the much needed link. Bentham Science Publishers Ltd, pp. 64-82. ISBN 9781608051236

2011

Lear, Martin (2011) Total synthesis and drug pursuits: laetirobins, lipstatins, platensimycins [ACP Tour, Japan]. In: Asia Core Program Lectureship Tour of Japan, 18-22 Dec 2011, Nagoya, Tokyo, and Tohoku, Japan.

Yang, Peng-Yu, Liu, Kai, Zhang, Chongjing, Chen, Grace Y. J., Shen, Yuan, Ngai, Mun Hong, Lear, Martin J. and Yao, Shao Q. (2011) Chemical modification and organelle-specific localization of orlistat-like natural-product-based probes. Chemistry - An Asian Journal, 6 (10). pp. 2762-2775. ISSN 1861-4728

2010

Eey, Stanley T.-C. and Lear, Martin J. (2010) A bismuth(III)-catalyzed Friedel−Crafts cyclization and stereocontrolled organocatalytic approach to (−)-platensimycin. Organic Letters, 12 (23). pp. 5510-5513. ISSN 1523-7060

Ngai, Mun H., Yang, Peng-Yu, Liu, Kai, Shen, Yuan, Wenk, Markus R., Yao, Shao Q. and Lear, Martin J. (2010) Click-based synthesis and proteomic profiling of lipstatin analogues. Chemical Communications, 46 (44). p. 8335. ISSN 1359-7345

Lear, Martin (2010) Exploring the glycolipidome via chemical mimicry. In: EMBO Conference Series: Chemical Biology 2010, 22 - 25 Sep 2010, EMBL Heidelberg, Germany.

Lear, Martin and Yao, Shao Q. (2010) New directions for old drugs. Project Report. National University of Singapore, Singapore.

Lear, Martin (2010) One small step for synthesis; one giant leap for total synthesis. In: 59th Natural Products Gordon Research Conference, July 25-30, 2010, Tilton, NH, USA.

Liu, Xiang Hui, Song, Hong Yan, Ma, Xiao Hua, Lear, Martin J. and Chen, Yu Zong (2010) Virtual screening prediction of new potential organocatalysts for direct aldol reactions. Journal of Molecular Catalysis A: Chemical, 319 (1-2). pp. 114-118. ISSN 1381-1169

Tan, Kevin and Lear, Martin (2010) Scientists tag malaria superbugs. Singapore Press Holdings.

Ch'ng, J.-H., Kotturi, S. R., Chong, A. G.-L., Lear, Martin J. and Tan, K. S.-W. (2010) A programmed cell death pathway in the malaria parasite Plasmodium falciparum has general features of mammalian apoptosis but is mediated by clan CA cysteine proteases. Cell Death and Disease, 1 (2). e26. ISSN 2041-4889

Simon, Oliver, Reux, Bastien, La Clair, James J. and Lear, Martin J. (2010) Total synthesis confirms laetirobin as a formal Diels-Alder adduct. Chemistry - An Asian Journal, 5 (2). pp. 342-351. ISSN 1861-4728

Gorelik, Sergey, Hongyan, Song, Lear, Martin J. and Hobley, Jonathan (2010) Transient Brewster angle reflectometry of spiropyran monolayers. Photochemical and Photobiological Sciences, 9 (2). pp. 141-151. ISSN 1474-905X

Yang, Peng-Yu, Liu, Kai, Ngai, Mun Hong, Lear, Martin J., Wenk, Markus R. and Yao, Shao Q. (2010) Activity-based proteome profiling of potential cellular targets of Orlistat - an FDA-approved drug with anti-tumor activities. Journal of the American Chemical Society, 132 (2). pp. 656-666. ISSN 0002-7863

2009

Lear, Martin J., Simon, Oliver, Foley, Timothy L., Burkart, Michael D., Baiga, Thomas J., Noel, Joseph P., DiPasquale, Antonio G., Rheingold, Arnold L. and La Clair, James J. (2009) Laetirobin from the parasitic growth of Laetiporus sulphurous on Robinia pseudoacacia. Journal of Natural Products, 72 (11). pp. 1980-1987. ISSN 0163-3864

Ali, Asif, Wenk, Markus R. and Lear, Martin J. (2009) Total synthesis of a fully lipidated form of phosphatidyl-myo-inositol dimannoside (PIM-2) of Mycobacterium tuberculosis. Tetrahedron Letters, 50 (40). pp. 5664-5666. ISSN 0040-4039

Kotturi, Santosh R., Tan, Jason S. and Lear, Martin J. (2009) A mild method for the protection of alcohols using a para-methoxybenzylthio tetrazole (PMB-ST) under dual acid–base activation. Tetrahedron Letters, 50 (37). pp. 5267-5269. ISSN 0040-4039

Song, Hong Y., Ngai, Mun H., Song, Zhen Y., MacAry, Paul A., Hobley, Jonathan and Lear, Martin J. (2009) Practical synthesis of maleimides and coumarin-linked probes for protein and antibody labelling via reduction of native disulfides. Organic & Biomolecular Chemistry, 7 (17). pp. 3400-3406. ISSN 1477-0520

Miao, Ru, Gramani, Subramanian G. and Lear, Martin J. (2009) Stereocontrolled entry to the tricyclo[3.3.0]oxoheptane core of bielschowskysin by a [2+2] cycloaddition of an allene-butenolide. Tetrahedron Letters, 50 (15). pp. 1731-1733. ISSN ISSN

Gorelik, Sergey, Hobley, Jonathan, Lear, Martin J., Song, Hongyan, Yong, Stanley Yew Siong and Cheng, Jianhua (2009) Quantification of transient absorption in photo-reactive monolayers using reflectometry in the vicinity of Brewster angle. International Journal of Nanoscience, 08 (01/02). pp. 213-218. ISSN 0219-581X

Lear, Martin J., Salmons, Brian, Gunzburg, Walter H. and Dangerfield, John A. (2009) Singapore R&D and globetrotting. Biotechnology Journal, 4 (2). pp. 179-185. ISSN ISSN

Dharmawan, Jorry, Kasapis, Stefan, Sriramula, Praveena, Lear, Martin J. and Curran, Philip (2009) Evaluation of aroma-active compounds in Pontianak Orange Peel Oil (Citrus nobilis Lour. Var.microcarpaHassk.) by gas chromatography−olfactometry, aroma reconstitution, and omission test. Journal of Agricultural and Food Chemistry, 57 (1). pp. 239-244. ISSN 0021-8561

2008

Li, Y., Song, H. Y., Lear, M. J., Gorelik, S., Tomczak, N. and Hobley, J. (2008) Optical detection of photo-activated protein adsorption using Brewster angle microscopy. In: PhotonicsGlobal@Singapore, 2008. IPGC 2008, 8-11 Dec 2008, Singapore.

Rodríguez, Abimael D., Lear, Martin J. and La Clair, James J. (2008) Identification of the binding of sceptrin to MreB via a bidirectional affinity protocol. Journal of the American Chemical Society, 130 (23). pp. 7256-7258. ISSN 0002-7863

Lear, Martin and Hobley, Jonathan (2008) You make it, I break it. COSMOS, 04 (01). pp. 99-129. ISSN 0219-6077

2007

Yoshimura, Fumihiko, Lear, Martin J., Ohashi, Isao, Koyama, Yasuhito and Hirama, Masahiro (2007) Synthesis of the entire carbon framework of the kedarcidin chromophore aglycon. Chemical Communications (29). p. 3057. ISSN 1359-7345

2006

Hirama, Masahiro, Akiyama, Kimio, Das, Parthasarathi, Mita, Takashi, Lear, Martin J., Iida, Kyo-ichiro, Sato, Itaru, Yoshimura, Fumihiko, Usuki, Toyonobu and Tero-Kubota, Shozo (2006) Direct observation of ESR spectra of bicyclic nine-membered enediynes at ambient temperature. Heterocycles, 69 (1). pp. 83-89. ISSN 0385-5414

2005

Koyama, Yasuhito, Lear, Martin J., Yoshimura, Fumihiko, Ohashi, Isao, Mashimo, Tomoko and Hirama, Masahiro (2005) Efficient construction of the kedarcidin chromophore ansamacrolide. Organic Letters, 7 (2). pp. 267-270. ISSN 1523-7060

2004

Usuki, Toyonobu, Mita, Takashi, Lear, Martin J., Das, Parthasarathi, Yoshimura, Fumihiko, Inoue, Masayuki, Hirama, Masahiro, Akiyama, Kimio and Tero-Kubota, Shozo (2004) Spin trapping of 13C-labeled p-benzynes generated by Masamune–Bergman cyclization of bicyclic nine-membered enediynes. Angewandte Chemie International Edition, 43 (39). pp. 5249-5253. ISSN 1433-7851

Ohashi, Isao, Lear, Martin J., Yoshimura, Fumihiko and Hirama, Masahiro (2004) Use of polystyrene-supported DBU in the synthesis and α-selective glycosylation study of the unstable Schmidt donor of L-kedarosamine. Organic Letters, 6 (5). pp. 719-722. ISSN 1523-7060

2003

Hobley, Jonathan, Lear, Martin and Fukumura, Hiroshi (2003) Photo-switching spiropyrans and related compounds. In: Photochemistry of organic molecules in isotropic and anisotropic media. Marcel Dekker, Inc, pp. 353-404. ISBN 9780824708832, 9780203014202

2002

Das, Parthasarathi, Mita, Takashi, Lear, Martin and Hirama, Masahiro (2002) Synthesis of 13C-labelled, bicyclic mimetics of natural enediynes. Chemical Communications (22). pp. 2624-2625. ISSN 1359-7345

Kobayashi, Shoji, Das, Parthasarathi, Wang, Guang Xing, Mita, Takashi, Lear, Martin J. and Hirama, Masahiro (2002) Diastereoselective additions of ethynyl Grignard reagent to erythrulose derivatives. Chemistry Letters, 31 (3). pp. 300-301. ISSN 0366-7022

2001

Kobayashi, Shoji, Ashizawa, Shukuko, Takahashi, Yusuke, Sugiura, Yukio, Nagaoka, Makoto, Lear, Martin J. and Hirama, Masahiro (2001) The first total synthesis of N1999-A2: absolute stereochemistry and stereochemical implications into DNA cleavage. Journal of the American Chemical Society, 123 (45). pp. 11294-11295. ISSN 0002-7863

Lear, Martin J., Yoshimura, Fumihiko and Hirama, Masahiro (2001) A direct and efficient α-selective glycosylation protocol for the kedarcidin sugar, L-mycarose: AgPF6 as a remarkable activator of 2-deoxythioglycosides. Angewandte Chemie International Edition, 40 (5). pp. 946-949. ISSN 1433-7851

1999

Lear, Martin J. and Hirama, Masahiro (1999) Convenient route to derivatives of the 2-deoxysugar subunits of the kedarcidin chromophore: L-mycarose and L-kedarosamine. Tetrahedron Letters, 40 (26). pp. 4897-4900. ISSN 0040-4039

1996

McLeod, H. L., Brunton, V. G., Eckardt, N., Lear, M. J., Robins, D. J., Workman, P. and Graham, M. A. (1996) In vivo pharmacology and anti-tumour evaluation of the tyrphostin tyrosine kinase inhibitor RG13022. British Journal of Cancer, 74 (11). pp. 1714-1718. ISSN 0007-0920

Brunton, V. G., Lear, M., McKeown, P., Robins, D. J. and Workman, P. (1996) Synthesis and antiproliferative activity of tyrphostins containing quinoline moieties. Anti-Cancer Drug Design, 11 (6). pp. 463-483. ISSN 0266-9536

Brunton, V. G., Kelland, L. R., Lear, M., Montgomary, G. J., Robertson, J. H., Robins, D. J., Queen, J. and Workman, P. (1996) Synthesis and biological evaluation of a series of tyrphostins containing nitrothiophene moieties as possible epidermal growth factor receptor tyrosine kinase inhibitors. Anti-Cancer Drug Design, 11 (4). pp. 265-295. ISSN 0266-9536

1994

Brunton, V. G., Lear, M., Robins, D. J., Williamson, S. and Workman, P. (1994) Synthesis and antiproliferative activity of tyrphostins containing heteroaromatic moieties. Anti-Cancer Drug Design, 9 (4). pp. 291-309. ISSN 0266-9536

This list was generated on Mon Jul 6 22:18:38 2020 BST.