Items where Creator is "Holden, Neil"

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Number of items: 25.

Article

Perry, Matthew W. D. and Björhall, Karin and Bonn, Britta K. and Carlsson, Johan and Chen, Yunhua and Eriksson, Anders and Fredlund, Linda and Hao, Hai'e and Holden, Neil S. and Karabelas, Kostas and Lindmark, Helena and Liu, Feifei and Pemberton, Nils and Petersen, Jens and Rodrigo Blomqvist, Sandra and Smith, Reed W. and Svensson, Tor and Terstiege, Ina and Tyrchan, Christian and Yang, Wenzhen and Zhao, Shuchun and Öster, Linda (2017) Design and synthesis of soluble and cell-permeable PI3Kδ inhibitors for long-acting inhaled administration. Journal of Medicinal Chemistry . ISSN 0022-2623

Shariff, Sami and Shelfoon, Christopher and Holden, Neil S. and Traves, Suzanne L. and Wiehler, Shahina and Kooi, Cora and Proud, David and Leigh, Richard (2017) Human rhinovirus infection of epithelial cells modulates airway smooth muscle migration. American Journal of Respiratory Cell and Molecular Biology . ISSN 1044-1549

Holden, Neil S. and George, Tresa and Rider, Christopher F. and Chandrasekhar, Ambika and Shah, Suharsh and Kaur, Manminder and Johnson, Malcolm and Siderovski, David P. and Leigh, Richard and Giembycz, Mark A. and Newton, Robert (2014) Induction of regulator of G-protein signaling 2 expression by long-acting β2-adrenoceptor agonists and glucocorticoids in human airway epithelial cells. Journal of Pharmacology and Experimental Therapeutics, 348 (1). pp. 12-24. ISSN 0022-3565

Kelly, M. M. and King, E. M. and Rider, C. F. and Gwozd, C. and Holden, Neil S. and Eddleston, J. and Zuraw, B. and Leigh, R. and O'Byrne, P. M. and Newton, R. (2012) Corticosteroid-induced gene expression in allergen-challenged asthmatic subjects taking inhaled budesonide. British Journal of Pharmacology, 165 (6). pp. 1737-1747. ISSN 0007-1188

Holden, Neil S. and Bell, Matthew J. and Rider, Christopher F. and King, Elizabeth M. and Gaunt, David D. and Leigh, Richard and Johnson, Malcolm and Siderovski, David P. and Heximer, Scott P. and Giembycz, Mark A. and Newton, Robert (2011) β2-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of bronchoprotection that is enhanced by glucocorticoids. Proceedings of the National Academy of Sciences of the United States of America, 108 (49). pp. 19713-19718. ISSN 1091-6490

Rider, Christopher F. and King, Elizabeth M. and Holden, Neil S. and Giembycz, Mark A. and Newton, Robert (2011) Inflammatory stimuli inhibit glucocorticoid-dependent transactivation in human pulmonary epithelial cells: rescue by long-acting beta2-adrenoceptor agonists. Journal of Pharmacology and Experimental Therapeutics, 338 (3). pp. 860-869. ISSN 0022-3565

Holden, Neil S. and Tacon, Claire E. (2011) Principles and problems of the electrophoretic mobility shift assay. Journal of Pharmacological and Toxicological Methods, 63 (1). pp. 7-14. ISSN 1056-8719

Tacon, Claire E. and Wiehler, Shahina and Holden, Neil S. and Newton, Robert and Proud, David and Leigh, Richard (2010) Human rhinovirus infection up-regulates MMP-9 production in airway epithelial cells via NF-{kappa}B. American Journal of Respiratory Cell and Molecular Biology, 43 (2). pp. 201-209. ISSN 1044-1549

Holden, Neil S. and Rider, C. F. and Bell, M. J. and Velayudhan, J. and King, E. M. and Kaur, M. and Salmon, M. and Giembycz, M. A. and Newton, R. (2010) Enhancement of inflammatory mediator release by beta(2)-adrenoceptor agonists in airway epithelial cells is reversed by glucocorticoid action. British journal of pharmacology, 160 (2). pp. 410-420. ISSN 0007-1188

Newton, Robert and King, Elizabeth M. and Gong, Wei and Rider, Christopher F. and Staples, Karl J. and Holden, Neil S. and Bergmann, Martin W. (2010) Glucocorticoids inhibit IL-1beta-induced GM-CSF expression at multiple levels: roles for the ERK pathway and repression by MKP-1. The Biochemical Journal, 427 (1). pp. 113-24. ISSN 0264-6021

King, Elizabeth M. and Holden, Neil S. and Gong, Wei and Rider, Christopher F. and Newton, Robert (2009) Inhibition of NF-kappaB-dependent transcription by MKP-1: transcriptional repression by glucocorticoids occurring via p38 MAPK. The Journal of biological chemistry, 284 (39). pp. 26803-26815. ISSN 0021-9258

King, Elizabeth M. and Kaur, Manminder and Gong, Wei and Rider, Christopher F. and Holden, Neil S. and Newton, Robert (2009) Regulation of tristetraprolin expression by interleukin-1β and dexamethasone in human pulmonary epithelial cells: Roles for nuclear factor-κB and p38 mitogen-activated protein kinase. The journal of pharmacology and experimental therapeutics, 330 (2). pp. 575-585. ISSN 0022-3565

Zaheer, Raza S. and Koetzler, Rommy and Holden, Neil S. and Wiehler, Shahina and Proud, David (2009) Selective transcriptional down-regulation of human rhinovirus-induced production of CXCL10 from airway epithelial cells via the MEK1 pathway. Journal of Immunology, 182 (8). pp. 4854-4864. ISSN 0022-1767

Koetzler, Rommy and Zaheer, Raza S. and Wiehler, Shahina and Holden, Neil S. and Giembycz, Mark A. and Proud, David (2009) Nitric oxide inhibits human rhinovirus-induced transcriptional activation of CXCL10 in airway epithelial cells. The Journal of Allergy and Clinical Immunology, 123 (1). 201-208.e9. ISSN 0091-6749

Kaur, Manminder and Holden, Neil S. and Wilson, Sylvia M. and Sukkar, Maria B. and Chung, Kian Fan and Barnes, Peter J. and Newton, Robert and Giembycz, Mark A. (2008) Effect of β2-adrenoceptor agonists and other cAMP-elevating agents on inflammatory gene expression in human ASM cells: a role for protein kinase A. American journal of physiology. Lung cellular and molecular physiology, 295 (3). L505-L514. ISSN 1040-0605

Holden, Neil S. and Squires, Paul E. and Kaur, Manminder and Bland, Rosemary and Jones, Carol E. and Newton, R. (Robert) (2008) Phorbol ester-stimulated NF-kappa B-dependent transcription : roles for isoforms of novel protein kinase C. Cellular Signalling, 20 (7). pp. 1338-1348. ISSN 0898-6568

Holden, Neil S. and Gong, W. and King, E. M. and Kaur, M. and Giembycz, M. A. and Newton, R. (2007) Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. British journal of pharmacology, 152 (6). pp. 891-902. ISSN 0007-1188

Newton, Robert and Holden, Neil S. (2007) Separating transrepression and transactivation: a distressing divorce for the glucocorticoid receptor? Molecular pharmacology, 72 (4). pp. 799-809. ISSN 0026-895X

Newton, Robert and Holden, Neil S. and Catley, Matthew C. and Oyelusi, Wale and Leigh, Richard and Proud, David and Barnes, Peter J. (2007) Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IκB kinase inhibitors. The journal of pharmacology and experimental therapeutics, 321 (2). pp. 734-42. ISSN 0022-3565

Chivers, Joanna E. and Gong, Wei and King, Elizabeth M. and Seybold, Joachim and Mak, Judith C. and Donnelly, Louise E. and Holden, Neil S. and Newton, Robert (2006) Analysis of the dissociated steroid RU24858 does not exclude a role for inducible genes in the anti-inflammatory actions of glucocorticoids. Molecular pharmacology, 70 (6). pp. 2084-2095. ISSN 0026-895X

Catley, Matthew C. and Chivers, Joanna E. and Holden, Neil S. and Barnes, Peter J. and Newton, Robert (2005) Validation of IKK beta as therapeutic target in airway inflammatory disease by adenoviral-mediated delivery of dominant-negative IKK beta to pulmonary epithelial cells. British journal of pharmacology, 145 (1). pp. 114-22. ISSN 0007-1188

Catley, Matthew C. and Cambridge, Lisa M. and Nasuhara, Yasuyuki and Ito, Kazuhiro and Chivers, Joanna E and Beaton, Andrew and Holden, Neil S. and Bergmann, Martin W. and Barnes, Peter J. and Newton, Robert (2004) Inhibitors of protein kinase C (PKC) prevent activated transcription: role of events downstream of NF-kappaB DNA binding. Journal of Biological Chemistry, 279 (18). pp. 18457-18466. ISSN 0021-9258

Holden, Neil S. and Catley, Matthew C. and Cambridge, Lisa M. and Barnes, Peter J. and Newton, Robert (2004) ICAM-1 expression is highly NF-kappaB-dependent in A549 cells. No role for ERK and p38 MAPK. European Journal of Biochemistry / FEBS, 271 (4). pp. 785-791. ISSN 1742-464X

Catley, Matthew C. and Chivers, Joanna E. and Cambridge, Lisa M. and Holden, Neil and Slater, Donna M. and Staples, Karl J. and Bergmann, Martin W. and Loser, Peter and Barnes, Peter J. and Newton, Robert (2003) IL-1beta-dependent activation of NF-kappaB mediates PGE2 release via the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase. FEBS Letters, 547 (1-3). pp. 75-79. ISSN 0014-5793

Newton, Robert and Holden, Neil (2003) Inhibitors of p38 mitogen-activated protein kinase. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy, 17 (2). pp. 113-29. ISSN 1173-8804

This list was generated on Mon Sep 25 19:07:19 2017 BST.