Items where Creator is "Holden, Neil"

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Number of items: 28.

Article

Pemberton, N, Mogemark, M, Arlbrandt, S, Bold, P, Cox, RJ, Gardelli, C, Holden, Neil, Karabelas, K, Karlsson, J, Lever, J, Li, X, Lindmark, H, Norberg, M, Perry, MWD, Petersen, J, Rodrigo Blomqvist, S, Thomas, M, Tyrchan, C, Westin Eriksson, A, Zlatoidsky, P and Öster, L (2018) Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3-Kinase (PI3K)-γ Inhibitors. Journal of Medical Chemistry, 61 (12). pp. 5435-5441. ISSN 0022-2623

Jenkins, Alex, Holden, Neil and Jones, Arwel (2018) Pulmonary Rehabilitation, Exercise, and Exacerbations of COPD: Known Clinical Efficacy and the Unknown Mechanisms. Chest, 153 (5). pp. 1281-1282. ISSN 0012-3692

Jenkins, Alex, Gowler, Holly, Curtis, Ffion, Holden, Neil, Bridle, Christopher and Jones, Arwel (2018) Efficacy of supervised maintenance exercise following pulmonary rehabilitation on health-care use: a systematic review and meta-analysis. International Journal of COPD, 13 . pp. 257-273. ISSN 1176-9106

Perry, Matthew W. D., Björhall, Karin, Bonn, Britta K., Carlsson, Johan, Chen, Yunhua, Eriksson, Anders, Fredlund, Linda, Hao, Hai'e, Holden, Neil S., Karabelas, Kostas, Lindmark, Helena, Liu, Feifei, Pemberton, Nils, Petersen, Jens, Rodrigo Blomqvist, Sandra, Smith, Reed W., Svensson, Tor, Terstiege, Ina, Tyrchan, Christian, Yang, Wenzhen, Zhao, Shuchun and Öster, Linda (2017) Design and synthesis of soluble and cell-permeable PI3Kδ inhibitors for long-acting inhaled administration. Journal of Medicinal Chemistry, 60 (12). pp. 5057-5071. ISSN 0022-2623

Shariff, Sami, Shelfoon, Christopher, Holden, Neil S., Traves, Suzanne L., Wiehler, Shahina, Kooi, Cora, Proud, David and Leigh, Richard (2017) Human rhinovirus infection of epithelial cells modulates airway smooth muscle migration. American Journal of Respiratory Cell and Molecular Biology, 56 (6). pp. 796-803. ISSN 1044-1549

Holden, Neil S., George, Tresa, Rider, Christopher F., Chandrasekhar, Ambika, Shah, Suharsh, Kaur, Manminder, Johnson, Malcolm, Siderovski, David P., Leigh, Richard, Giembycz, Mark A. and Newton, Robert (2014) Induction of regulator of G-protein signaling 2 expression by long-acting β2-adrenoceptor agonists and glucocorticoids in human airway epithelial cells. Journal of Pharmacology and Experimental Therapeutics, 348 (1). pp. 12-24. ISSN 0022-3565

Kelly, M. M., King, E. M., Rider, C. F., Gwozd, C., Holden, Neil S., Eddleston, J., Zuraw, B., Leigh, R., O'Byrne, P. M. and Newton, R. (2012) Corticosteroid-induced gene expression in allergen-challenged asthmatic subjects taking inhaled budesonide. British Journal of Pharmacology, 165 (6). pp. 1737-1747. ISSN 0007-1188

Holden, Neil S., Bell, Matthew J., Rider, Christopher F., King, Elizabeth M., Gaunt, David D., Leigh, Richard, Johnson, Malcolm, Siderovski, David P., Heximer, Scott P., Giembycz, Mark A. and Newton, Robert (2011) β2-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of bronchoprotection that is enhanced by glucocorticoids. Proceedings of the National Academy of Sciences of the United States of America, 108 (49). pp. 19713-19718. ISSN 1091-6490

Rider, Christopher F., King, Elizabeth M., Holden, Neil S., Giembycz, Mark A. and Newton, Robert (2011) Inflammatory stimuli inhibit glucocorticoid-dependent transactivation in human pulmonary epithelial cells: rescue by long-acting beta2-adrenoceptor agonists. Journal of Pharmacology and Experimental Therapeutics, 338 (3). pp. 860-869. ISSN 0022-3565

Holden, Neil S. and Tacon, Claire E. (2011) Principles and problems of the electrophoretic mobility shift assay. Journal of Pharmacological and Toxicological Methods, 63 (1). pp. 7-14. ISSN 1056-8719

Tacon, Claire E., Wiehler, Shahina, Holden, Neil S., Newton, Robert, Proud, David and Leigh, Richard (2010) Human rhinovirus infection up-regulates MMP-9 production in airway epithelial cells via NF-{kappa}B. American Journal of Respiratory Cell and Molecular Biology, 43 (2). pp. 201-209. ISSN 1044-1549

Holden, Neil S., Rider, C. F., Bell, M. J., Velayudhan, J., King, E. M., Kaur, M., Salmon, M., Giembycz, M. A. and Newton, R. (2010) Enhancement of inflammatory mediator release by beta(2)-adrenoceptor agonists in airway epithelial cells is reversed by glucocorticoid action. British journal of pharmacology, 160 (2). pp. 410-420. ISSN 0007-1188

Newton, Robert, King, Elizabeth M., Gong, Wei, Rider, Christopher F., Staples, Karl J., Holden, Neil S. and Bergmann, Martin W. (2010) Glucocorticoids inhibit IL-1beta-induced GM-CSF expression at multiple levels: roles for the ERK pathway and repression by MKP-1. The Biochemical Journal, 427 (1). pp. 113-24. ISSN 0264-6021

King, Elizabeth M., Holden, Neil S., Gong, Wei, Rider, Christopher F. and Newton, Robert (2009) Inhibition of NF-kappaB-dependent transcription by MKP-1: transcriptional repression by glucocorticoids occurring via p38 MAPK. The Journal of biological chemistry, 284 (39). pp. 26803-26815. ISSN 0021-9258

King, Elizabeth M., Kaur, Manminder, Gong, Wei, Rider, Christopher F., Holden, Neil S. and Newton, Robert (2009) Regulation of tristetraprolin expression by interleukin-1β and dexamethasone in human pulmonary epithelial cells: Roles for nuclear factor-κB and p38 mitogen-activated protein kinase. The journal of pharmacology and experimental therapeutics, 330 (2). pp. 575-585. ISSN 0022-3565

Zaheer, Raza S., Koetzler, Rommy, Holden, Neil S., Wiehler, Shahina and Proud, David (2009) Selective transcriptional down-regulation of human rhinovirus-induced production of CXCL10 from airway epithelial cells via the MEK1 pathway. Journal of Immunology, 182 (8). pp. 4854-4864. ISSN 0022-1767

Koetzler, Rommy, Zaheer, Raza S., Wiehler, Shahina, Holden, Neil S., Giembycz, Mark A. and Proud, David (2009) Nitric oxide inhibits human rhinovirus-induced transcriptional activation of CXCL10 in airway epithelial cells. The Journal of Allergy and Clinical Immunology, 123 (1). 201-208.e9. ISSN 0091-6749

Kaur, Manminder, Holden, Neil S., Wilson, Sylvia M., Sukkar, Maria B., Chung, Kian Fan, Barnes, Peter J., Newton, Robert and Giembycz, Mark A. (2008) Effect of β2-adrenoceptor agonists and other cAMP-elevating agents on inflammatory gene expression in human ASM cells: a role for protein kinase A. American journal of physiology. Lung cellular and molecular physiology, 295 (3). L505-L514. ISSN 1040-0605

Holden, Neil S., Squires, Paul E., Kaur, Manminder, Bland, Rosemary, Jones, Carol E. and Newton, R. (Robert) (2008) Phorbol ester-stimulated NF-kappa B-dependent transcription : roles for isoforms of novel protein kinase C. Cellular Signalling, 20 (7). pp. 1338-1348. ISSN 0898-6568

Holden, Neil S., Gong, W., King, E. M., Kaur, M., Giembycz, M. A. and Newton, R. (2007) Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. British journal of pharmacology, 152 (6). pp. 891-902. ISSN 0007-1188

Newton, Robert and Holden, Neil S. (2007) Separating transrepression and transactivation: a distressing divorce for the glucocorticoid receptor? Molecular pharmacology, 72 (4). pp. 799-809. ISSN 0026-895X

Newton, Robert, Holden, Neil S., Catley, Matthew C., Oyelusi, Wale, Leigh, Richard, Proud, David and Barnes, Peter J. (2007) Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IκB kinase inhibitors. The journal of pharmacology and experimental therapeutics, 321 (2). pp. 734-42. ISSN 0022-3565

Chivers, Joanna E., Gong, Wei, King, Elizabeth M., Seybold, Joachim, Mak, Judith C., Donnelly, Louise E., Holden, Neil S. and Newton, Robert (2006) Analysis of the dissociated steroid RU24858 does not exclude a role for inducible genes in the anti-inflammatory actions of glucocorticoids. Molecular pharmacology, 70 (6). pp. 2084-2095. ISSN 0026-895X

Catley, Matthew C., Chivers, Joanna E., Holden, Neil S., Barnes, Peter J. and Newton, Robert (2005) Validation of IKK beta as therapeutic target in airway inflammatory disease by adenoviral-mediated delivery of dominant-negative IKK beta to pulmonary epithelial cells. British journal of pharmacology, 145 (1). pp. 114-22. ISSN 0007-1188

Catley, Matthew C., Cambridge, Lisa M., Nasuhara, Yasuyuki, Ito, Kazuhiro, Chivers, Joanna E, Beaton, Andrew, Holden, Neil S., Bergmann, Martin W., Barnes, Peter J. and Newton, Robert (2004) Inhibitors of protein kinase C (PKC) prevent activated transcription: role of events downstream of NF-kappaB DNA binding. Journal of Biological Chemistry, 279 (18). pp. 18457-18466. ISSN 0021-9258

Holden, Neil S., Catley, Matthew C., Cambridge, Lisa M., Barnes, Peter J. and Newton, Robert (2004) ICAM-1 expression is highly NF-kappaB-dependent in A549 cells. No role for ERK and p38 MAPK. European Journal of Biochemistry / FEBS, 271 (4). pp. 785-791. ISSN 1742-464X

Catley, Matthew C., Chivers, Joanna E., Cambridge, Lisa M., Holden, Neil, Slater, Donna M., Staples, Karl J., Bergmann, Martin W., Loser, Peter, Barnes, Peter J. and Newton, Robert (2003) IL-1beta-dependent activation of NF-kappaB mediates PGE2 release via the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase. FEBS Letters, 547 (1-3). pp. 75-79. ISSN 0014-5793

Newton, Robert and Holden, Neil (2003) Inhibitors of p38 mitogen-activated protein kinase. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy, 17 (2). pp. 113-29. ISSN 1173-8804

This list was generated on Wed Aug 12 22:46:37 2020 BST.