![]() | Up a level |
Cuskin, Fiona, Flint, James E., Gloster, Tracey M., Morland, Carl, Basle, Arnaud, Henrissat, Bernard, Coutinho, Pedro M., Strazzulli, Andrea, Solovyova, Alexandra S., Davies, Gideon J. and Gilbert, Harry J. (2012) How nature can exploit nonspecific catalytic and carbohydrate binding modules to create enzymatic specificity. Proceedings of the National Academy of Sciences, 109 (51). pp. 20889-20894. ISSN 0027-8424
Montanier, C. Y., Correia, M. A. S., Flint, J. E., Zhu, Y., Basl���©, A., McKee, L. S., Prates, J. A. M., Polizzi, S., Coutinho, P. M., Lewis, R. J., Henrissat, B., Fontes, C. M. G. A. and Gilbert, H. J. (2011) A novel, noncatalytic carbohydrate-binding module displays specificity for galactose-containing polysaccharides through calcium-mediated oligomerization. Journal of Biological Chemistry, 286 (25). pp. 22499-22509. ISSN 0021-9258
Montanier, Cedric, Flint, James E., Bolam, David N., Xie, Hefang, Liu, Ziyuan, Rogowski, Artur, Weiner, David P., Ratnaparkhe, Supriya, Nurizzo, Didier, Roberts, Shirley M., Turkenburg, Johan P., Davies, Gideon J. and Gilbert, Harry J. (2010) Circular permutation provides an evolutionary link between two families of calcium-dependent carbohydrate binding modules. The Journal of Biological Chemistry, 285 (41). pp. 31742-31754. ISSN 0021-9258
Correia, Ma��rcia A. S., Abbott, D. Wade, Gloster, Tracey M., Fernandes, Va��nia O., Prates, Jose�� A. M., Montanier, Cedric, Dumon, Claire, Williamson, Michael P., Tunnicliffe, Richard B., Liu, Ziyuan, Flint, James E., Davies, Gideon J., Henrissat, Bernard, Coutinho, Pedro M., Fontes, Carlos M. G. A. and Gilbert, Harry J. (2010) Signature active site architectures illuminate the molecular basis for ligand specificity in family 35 carbohydrate binding module. Biochemistry, 49 (29). pp. 6193-6205. ISSN 0006-2960
Tailford, Louise E., Ducros, Valerie M.-A., Flint, James E., Roberts, Shirley M., Morland, Carl, Zechel, David L., Smith, Nicola, Bjornvad, Mads E., Borchert, Torben V., Wilson, Keith S., Davies, Gideon J. and Gilbert, Harry J. (2009) Understanding how diverse β-mannanases recognize heterogeneous substrates. Biochemistry, 48 (29). pp. 7009-7018. ISSN 0006-2960
Leung, W. C., Hessel, S., Meplan, C., Flint, J., Oberhauser, V., Tourniaire, F., Hesketh, J. E., Von Lintig, J. and Lietz, G. (2009) Two common single nucleotide polymorphisms in the gene encoding β-carotene 15,15′-monoxygenase alter β-carotene metabolism in female volunteers. FASEB Journal, 23 (4). pp. 1041-1053. ISSN 0892-6638
Montanier, Cedric, Money, Victoria A., Pires, Virginia M. R., Flint, James E., Pinheiro, Benedita A., Goyal, Arun, Prates, Jose A. M., Izumi, Atsushi, Stalbrand, Henrik, Morland, Carl, Cartmell, Alan, Kolenova, Katarina, Topakas, Evangelos, Dodson, Eleanor J., Bolam, David N., Davies, Gideon J., Fontes, Carlos M. G. A. and Gilbert, Harry J. (2009) The active site of a carbohydrate esterase displays divergent catalytic and noncatalytic binding functions. PLoS Biology, 7 (3). e1000071. ISSN 1544-9173
Montanier, Cedric, Van Bueren, Alicia Lammerts, Dumon, Claire, Flint, James E., Correia, Marcia A., Prates, Jose A., Firbank, Susan J., Lewis, Richard J., Grondin, Gilles G., Ghinet, Mariana G., Gloster, Tracey M., Herve, Cecile, Knox, J. Paul, Talbot, Brian G., Turkenburg, Johan P., Kerovuo, Janne, Brzezinski, Ryszard, Fontes, Carlos M. G. A., Davies, Gideon J., Boraston, Alisdair B. and Gilbert, Harry J. (2009) Evidence that family 35 carbohydrate binding modules display conserved specificity but divergent function. Proceedings of the National Academy of Sciences, 106 (9). pp. 3065-3070. ISSN 0027-8424
Dumon, Claire, Varvak, Alexander, Wall, Mark A., Flint, James E., Lewis, Richard J., Lakey, Jeremy H., Morland, Carl, Luginbuhl, Peter, Healey, Shaun, Todaro, Thomas, DeSantis, Grace, Sun, May, Parra-Gessert, Lilian, Tan, Xuqiu, Weiner, David P. and Gilbert, Harry J. (2008) Engineering hyperthermostability into a GH11 xylanase is mediated by subtle changes to protein structure. The Journal of biological chemistry, 283 (33). pp. 22557-22564. ISSN 0021-9258
Correia, Marcia A. S., Prates, Jose A. M., Bras, Joana, Fontes, Carlos M. G. A., Newman, Joseph A., Lewis, Richard J., Gilbert, Harry J. and Flint, James E. (2008) Crystal structure of a cellulosomal family 3 carbohydrate esterase from Clostridium thermocellum provides Insights into the mechanism of substrate recognition. Journal of Molecular Biology, 379 (1). pp. 64-72. ISSN 0022-2836
Vardakou, Maria, Dumon, Claire, Murray, James W., Christakopoulos, Paul, Weiner, David P., Juge, Nathalie, Lewis, Richard J., Gilbert, Harry J. and Flint, James E. (2008) Understanding the structural basis for substrate and inhibitor recognition in eukaryotic GH11 xylanases. Journal of Molecular Biology, 375 (5). pp. 1293-1305. ISSN 0022-2836
Blake, Anthony W., McCartney, Lesley, Flint, James E., Bolam, David N., Boraston, Alisdair B., Gilbert, Harry J. and Knox, J. Paul (2006) Understanding the biological rationale for the diversity of cellulose-directed carbohydrate-binding modules in prokaryotic enzymes. Journal of Biological Chemistry, 281 (39). pp. 29321-29329. ISSN 0021-9258
Xie, Hefang, Flint, James, Vardakou, Maria, Lakey, Jeremy H., Lewis, Richard J., Gilbert, Harry J. and Dumon, Claire (2006) Probing the structural basis for the difference in thermostability displayed by family 10 xylanases. Journal of Molecular Biology, 360 (1). pp. 157-167. ISSN 0022-2836
McCartney, Lesley, Blake, Anthony W., Flint, James, Bolam, David N., Boraston, Alisdair B., Gilbert, Harry J. and Knox, J.Paul (2006) Differential recognition of plant cell walls by microbial xylan-specific carbohydrate-binding modules. Proceedings of the National Academy of Sciences of the United States of America, 103 (12). pp. 4765-4770. ISSN 0027-8424
Vardakou, Maria, Flint, James, Christakopoulos, Paul, Lewis, Richard J., Gilbert, Harry J. and Murray, James W. (2005) A family 10 Thermoascus aurantiacus xylanase utilizes arabinose decorations of xylan as significant substrate specificity determinants. Journal of Molecular Biology, 352 (5). pp. 1060-1067. ISSN 0022-2836
Flint, James, Bolam, DAvid N., Nurizzo, Didier, Taylor, Edward J., Williamson, Michael P., Walters, Christopher, Davies, Gideon J. and Gilbert, Harry J. (2005) Probing the mechanism of ligand recognition in family 29 carbohydrate-binding modules. The Journal of Biological Chemistry, 280 (25). pp. 23718-23726. ISSN 0021-9258
Flint, James, Nurizzo, Didier, Harding, Stephen E., Longman, Emma, Davies, Gideon J., Gilbert, Harry J. and Bolam, David N. (2004) Ligand-mediated dimerization of a carbohydrate-binding module reveals a novel mechanism for protein-carbohydrate recognition. Journal of Molecular Biology, 337 (2). pp. 417-426. ISSN 0022-2836