Items where Creator is "Lappin, Graham"

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Lappin, Graham (2015) A historical perspective on radioisotopic tracers in metabolism and biochemistry. Bioanalysis, 7 (5). pp. 531-540. ISSN 1757-6180


Lappin, G., Boyce, M. J., Matzow, T., Lociuro, S., Seymour, M. and Warrington, S. J. (2013) A microdose study of 14C-AR-709 in healthy men: pharmacokinetics, absolute bioavailability and concentrations in key compartments of the lung. European Journal of Clinical Pharmacology, 69 (9). pp. 1673-1682. ISSN 0031-6970

Lappin, Graham, Noveck, Robert and Burt, Tal (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism and Toxicology, 9 (7). pp. 817-834. ISSN 1742-5255


Duchateau, Guus, Cochrane, Brett, Windebank, Sam, Herudzinska, Justyna, Sanghera, Davindera, Burian, Angela, Muller, Markus, Zeitlinger, Markus and Lappin, Graham (2012) Absolute oral bioavailability and metabolic turnover of β-sitosterol in healthy subjects. Drug Metabolism and Disposition, 40 (10). pp. 2026-2030. ISSN 0090-9556

Croft, Marie, Keely, Brendan, Moss, Ian, Tann, Lan and Lappin, Graham (2012) Predicting drug candidate victims of drug-drug interactions, using microdosing. Clinical Pharmacokinetics, 51 (4). pp. 237-246. ISSN 0312-5963

Lappin, Graham, Seymour, Mark, Gross, Gerhard, Jorrgensen, Martin, Kall, Morten and Kvaerno, L.isbet (2012) Meeting the MIST regulations: Human metabolism in Phase I using AMS and a tiered bioanalytical approach. Bioanalysis, 4 (4). pp. 407-416. ISSN 1757-6180


Lappin, G., Shishikura, Y., Jochemsen, R., Weaver, R. J., Gesson, C., Brian Houston, J., Oosterhuis, B., Bjerrum, O. J., Grynkiewicz, G., Alder, J., Rowland, M. and Garner, C. (2011) Comparative pharmacokinetics between a microdose and therapeutic dose for clarithromycin, sumatriptan, propafenone, paracetamol (acetaminophen), and phenobarbital in human volunteers. European Journal of Pharmaceutical Sciences, 43 (3). pp. 141-150. ISSN 0928-0987

Lappin, Graham (2011) Microdosing: pharmacokinetic and metabolism data early in the drug development process. In: Pharmacokinetics in drug development: advanves and applications. Pharmacokinetics in Drug Development (3). Springer, New York. ISBN 9781441979377

Lappin, Graham, Seymour, Mark, Young, Graeme, Higton, David and Hill, Howard M. (2011) An AMS method to determine analyte recovery from pharmacokinetic studies with concomitant extravascular and intravenous administration. Bioanalysis, 3 (4). pp. 407-410. ISSN 1757-6180

Lappin, Graham, Seymour, Mark, Young, Graeme, Higton, David and Hill, Howard M. (2011) AMS method validation for quantitation in pharmacokinetic studies with concomitant extravascular and intravenous administration. Bioanalysis, 3 (4). pp. 393-405. ISSN 1757-6180

Wagner, Claudia C., Simpson, Marie, Zeitlinger, Markus, Bauer, Martin, Karch, Rudolf, Abrahim, Aiman, Feurstein, Thomas, Schutz, Matthius, Kletter, Kurt, Muller, Markus, Lappin, Graham and Langer, Oliver (2011) A combined accelerator mass spectrometry-positron emission tomography human microdose study with 14C- and 11C-labelled verapamil. Clinical Pharmacokinetics, 50 (2). pp. 111-120. ISSN 0312-5963


Lappin, Graham (2010) Pharmacokinetics II: 14C-labelled microdosing in assessing drug pharmacokinetics at phase-0. In: Clinical Pharmacology, Current Topics and Case Studies. Springer, pp. 155-165. ISBN 9783709101438

Lappin, Graham and Seymour, Mark (2010) Addressing metabolite safety during first-in-man studies using 14C-labeled drug and accelerator mass spectrometry. Bioanalysis, 2 (7). pp. 1315-1324. ISSN 1757-6180

Rose, Les, Jamieson, Allan, Lappin, Graham and Kerr, Morag (2010) Professional standards for the life sciences. Biologist, 57 (2). pp. 63-64. ISSN 0006-3347

Lappin, Graham, Shishikura, Yoko, Jochemsen, Roeline, Weaver, Richard John, Gesson, Charlotte, Houston, Brian, Oosterhuis, Berend, Bjerrum, Ole J., Rowland, Malcolm and Garner, Colin (2010) Pharmacokinetics of fexofenadine: evaluation of a microdose and assessment of absolute oral bioavailability. European Journal of Pharmaceutical Sciences, 40 (2). pp. 125-131. ISSN 0928-0987

Simpson, M., Lappin, G. and Keely, B. J. (2010) Development of 2D chiral chromatography with accelerator mass spectrometry for quantification of 14C-labeled R- and S-verapamil in plasma. Bioanalysis, 2 (3). pp. 397-405. ISSN 1757-6180

Lappin, Graham (2010) Microdosing: current and the future. Bioanalysis, 2 (3). pp. 509-517. ISSN 1757-6180

Bergmann, L., Berns, B., Dalgleish, A. G., von Euler, M., Hecht, T. T., Lappin, G. L., Reed, N., Palmeri, S., Smyth, J., Embacher-Aichorn, S. and Zwierzina, H. (2010) Investigator-initiated trials of targeted oncology agents: why independent research is at risk? Annals of Oncology, 21 (8). pp. 1573-1578. ISSN 0923-7534


Comezglu, S. Nilgun, Ly, Van T., Zhang, Donglu, Humphreys, W. Griffith, Bonacorsi, Samuel J., Everett, Donald W., Cohen, Marvin B., Gan, Jinping, Beumer, Jan H., Beijnen, Jos H., Schellens, H. M. and Lappin, Graham (2009) Biotransformation profiling of [14C]Ixabepilone in human plasma, urine and feces samples using accelerator mass spectrometry (AMS). Drug Metabolism and Pharmacokinetics, 24 (6). pp. 511-522. ISSN 1347-4367

Lappin, Graham (2009) The mounting evidence for microdosing. EBR - European Biopharmaceutical Review (WINTER). pp. 52-54. ISSN 1364-369X

Lappin, Graham, Wagner, Claudia C., Langer, Oliver and van de Merbel, Nico (2009) New ultrasensitive detection technologies and techniques for use in microdosing studies. Bioanalysis, 1 (2). pp. 357-366. ISSN 1757-6199

Madan, Ajay, O'Brien, Zhihong, Wen, Jianyun, O'Brien, Chris, Farber, Robert H., Beaton, Graham, Crowe, Paul, Oosterhuis, Berend, Garner, R. Colin, Lappin, Graham and Bozigian, Haig P. (2009) A pharmacokinetic evaluation of five H1 antagonists after an oral and intravenous microdose to human subjects. British Journal of Clinical Pharmacology, 67 (3). pp. 288-298. ISSN 0306-5251

Baxter, M., Castle, L., Crews, H. M., Rose, M., Garner, C., Lappin, Graham and Leong, D. (2009) A sensitive method for the determination of chlorine-36 in foods using accelerator mass spectrometry. Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment, 26 (1). pp. 139-144. ISSN 0265-203X


Lappin, Graham and Garner, R. Colin (2008) The utility of microdosing over the past 5 years. Expert Opinion on Drug Metabolism and Toxicology, 4 (12). pp. 1499-1506. ISSN 1742-5255

Garner, Colin and Lappin, Graham (2008) Trial by microdose. Chemistry and Industry (London) (19). pp. 23-24. ISSN 0009-3068

Lappin, Graham and Stevens, Lloyd (2008) Biomedical accelerator mass spectrometry: Recent applications in metabolism and pharmacokinetics. Expert Opinion on Drug Metabolism and Toxicology, 4 (8). pp. 1021-1033. ISSN 1742-5255

Lappin, Graham, Simpson, M., Shishikura, Y. and Garner, C. (2008) High-performance liquid chromatography accelerator mass spectrometry: Correcting for losses during analysis by internal standardization. Analytical Biochemistry, 378 (1). pp. 93-95. ISSN 0003-2697

Wagner, C. C., Muller, M., Lappin, Graham and Langer, O. (2008) Positron emission tomography for use in microdosing studies. Current Opinion in Drug Discovery and Development, 11 (1). pp. 104-110. ISSN 1367-6733


Lappin, Graham and Garner, R. C. (2006) Absolute bioavailability: the complete picture. European Pharmaceutical Contractor (AUTUMN). pp. 88-89. ISSN 1364-369X

Lappin, Graham, Kuhnz, Wilhelm, Jochemsen, Roeline, Kneer, Johannes, Chaudhary, Ajai, Oosterhuis, Berend, Drijfhout, Willem Jan, Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Lappin, Graham, Garner, R. C., Meyers, T., Powell, J. and Varley, P. (2006) Novel use of accelerator mass spectrometry for the quantification of low levels of systemic therapeutic recombinant protein. Journal of Pharmaceutical and Biomedical Analysis, 41 (4). pp. 1299-1302. ISSN 0731-7085

Lappin, Graham, Rowland, Malcolm and Garner, R. Colin (2006) The use of isotopes in the determination of absolute bioavailability of drugs in humans. Expert Opinion on Drug Metabolism and Toxicology, 2 (3). pp. 419-427. ISSN 1742-5255

Klem, B., Lappin, Graham, Nicholson, S., Van De Wetering, J., De Vries, D. E., Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham and Temple, Simon (2006) Radiotracers in drug development. Taylor Francis CRC Press, Florida, USA. ISBN 0849333474, 9780849333477

Garner, R.Colin and Lappin, Graham (2006) The phase 0 microdosing concept. British Journal of Clinical Pharmacology, 61 (4). pp. 367-370. ISSN 0306-5251

Lappin, Graham and Garner, C. (2006) Absolute bioavailability studies in humans: the merits of accelerator mass spectrometry. EBR - European Biopharmaceutical Review (SPRING). pp. 95-99. ISSN 1364-369X

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027


Sarapa, Nenad, Hsyu, Poe-Hirr, Lappin, Graham and Garner, Ronald Folin (2005) The application of accelerator mass spectrometry to absolute bioavailability studies in humans: Simultaneous administration of an intravenous microdose of 14C-nelfinavir mesylate solution and oral nelfinavir to healthy volunteers. Journal of Clinical Pharmacology, 45 (10). pp. 1198-1205. ISSN 0091-2700

Lappin, Graham and Garner, R. Colin (2005) The use of accelerator mass spectrometry to obtain early human ADME/PK data. Expert Opinion on Drug Metabolism and Toxicology, 1 (1). pp. 23-31. ISSN 1742-5255


Lappin, Graham (2004) Animal experimentation, the worst form of science? Biologist, 51 (1). p. 3. ISSN 0006-3347

Lappin, Graham and Garner, R. Colin (2004) Current perspectives of 14C-isotope measurement in biomedical accelerator mass spectrometry. Analytical and Bioanalytical Chemistry, 378 (2). pp. 356-364. ISSN 1618-2642


Bacon, James R., Williamson, Gary, Garner, R. Colin, Lappin, Graham, Langouet, Sophie and Bao, Yongping (2003) Sulforaphane and quercetin modulate PhIP-DNA adduct formation in human HepG2 cells and hepatocytes. Carcinogenesis, 24 (12). pp. 1903-1911. ISSN 0143-3334

Lappin, Graham (2003) Biology meets nuclear physics. Biologist, 50 (4). pp. 183-187. ISSN 0006-3347

van Ravenzwaay, B., Hardwick, T. D., Needham, D., Pethen, S. and Lappin, G. J. (2003) Comparative metabolism of 2,4-dichlorophenoxyacetic acid (2,4-D) in rat and dog. Xenobiotica: the fate of foreign compounds in biological systems, 33 (8). pp. 805-21. ISSN 0049-8254

Laird, W. J. D., Gledhill, A. J. and Lappin, Graham (2003) Metabolism of methyl-(E)-2-2-6-(2-cyanophenoxy)pyrimidin-4- yloxyphenyl-3-methoxyacrylate (azoxystrobin) in rat. Xenobiotica, 33 (6). pp. 677-690. ISSN 0049-8254

Lappin, Graham and Garner, R. Colin (2003) Big physics, small doses: the use of AMS and PET in human microdosing of development drugs. Nature Reviews Drug Discovery, 2 (3). pp. 233-240. ISSN 1474-1776

Lappin, Graham and Garner, R. Colin (2003) Ultra-sensitive detection of radiolabelled drugs and their metabolites using accelerator mass spectrometry [chapter 11]. Handbook of Analytical Separations, 4 . pp. 331-349. ISSN 1567-7192


Lappin, Graham, Hardwick, T. D., Stow, R., Pigott, G. H. and Van Ravenzwaay, B. (2002) Absorption, metabolism and excretion of 4-chloro-2-methylphenoxyacetic acid (MCPA) in rat and dog. Xenobiotica, 32 (2). pp. 153-163. ISSN 0049-8254

Lappin, Graham (2002) Chemical toxins and body defences. Biologist, 49 (1). pp. 33-37. ISSN 0006-3347


Lappin, Graham, Pritchard, D., Moore, R. B. and Laird, W. J. D. (1996) Metabolism of 2,3,5,6-tetrachloronitrobenzene (tecnazene) in rat. Xenobiotica, 26 (1). pp. 65-77. ISSN 0049-8254


Provan, W. M., Eyton-Jones, H., Lappin, G., Pritchard, D., Moore, R. B. and Green, T. (1995) The incorporation of radiolabelled sulphur from captan into protein and its impact on a DNA binding study. Chemico-Biological Interactions, 96 (2). pp. 173-184. ISSN 0009-2797


Lappin, Graham, Tampion, J. and Stride, J. (1989) The biotransformation of monoterpenoids by tissue plant culture. In: Secondary metabolism in plant cell cultures. Cambridge University Press. ISBN UNSPECIFIED


Lappin, Graham J., Stride, John D. and Tampion, John (1987) Biotransformation of monoterpenoids by suspension cultures of Lavandula angustifolia. Phytochemistry, 26 (4). pp. 995-997. ISSN 0031-9422

This list was generated on Wed Aug 10 02:32:39 2022 BST.