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Quayle, Lewis A., Pereira, Maria G., Scheper, Gerjan, Wiltshire, Tammy, Peake, Ria E., Hussain, Issam, Rea, Carol A. and Bates, Timothy E. (2017) Anti-angiogenic drugs: direct anti-cancer agents with mitochondrial mechanisms of action. Oncotarget, 10 . ISSN 1949-2553
Walker, A. J., Grainge, M, Bates, T. E. and Card, T. R. (2012) Survival of glioma and colorectal cancer patients using tricyclic antidepressants post-diagnosis. Cancer Causes and Control, 23 (12). pp. 1959-1964. ISSN 0957-5243
Adbel-Razaq, W., Kendall, D. A. and Bates, T. E. (2011) The effects of antidepressants on mitochondrial function in a model cell system and isolated mitochondria. Neurochemical Research, 36 (2). pp. 327-338. ISSN 0364-3190
Walker, A. J., Card, T., Bates, T. E. and Muir, K. (2011) Tricyclic antidepressants and the incidence of certain cancers: a study using the GPRD. British Journal of Cancer, 104 (1). pp. 193-197. ISSN 0007-0920
Aloysius, Mark M., Hewavisenthi, Shivanthi J. De Silva, Bates, Timothy E., Rowlands, Brian J., Lobo, Dileep N. and Zaitoun, Abed M. (2010) Predictive value of tumor proliferative indices in periampullary cancers: Ki-67, mitotic activity index (MI) and volume corrected mitotic index (M/V) using tissue microarrays. World Journal of Surgery, 34 (9). pp. 2115-2121. ISSN 0364-2313
Aloysius, Mark M., Zaitoun, Abed M., Bates, Timothy E., Ilyas, Mohammad, Constantin-Teodosiu, Dumitru, Rowlands, Brian J. and Lobo, Dileep N. (2010) Immunohistochemical expression of mitochondrial membrane complexes (MMCs) I, III, IV and V in malignant and benign periampullary epithelium: a potential target for drug therapy of periampullary cancer? BMC Cancer, 10 . p. 80. ISSN 1471-2407
Aloysius, Mark M., Zaitoun, Abed M., Bates, Timothy E., Albasri, Abdulkader, Ilyas, Mohammad, Rowlands, Brian J. and Lobo, Dileep N. (2009) Complete absence of M2-pyruvate kinase expression in benign pancreatic ductal epithelium and pancreaticobiliary and duodenal neoplasia. BMC cancer, 9 . p. 327. ISSN 1471-2407
Pardon, Marie-Christine, Sarmad, Sarir, Rattray, Ivan, Bates, Timothy E., Scullion, Gillian A., Marsden, Charles A., Barrett, David A., Lowe, James and Kendall, David A. (2009) Repeated novel cage exposure-induced improvement of early Alzheimer's-like cognitive and amyloid changes in TASTPM mice is unrelated to changes in brain endocannabinoids levels. Neurobiology of Aging, 30 (7). pp. 1099-1113. ISSN 0197-4580
Calabrese, Vittorio, Cornelius, Carolin, Mancuso, Cesare, Pennisi, Giovanni, Calafato, Stella, Bellia, Francesco, Bates, Timothy E., Giuffrida Stella, Anna Maria, Schapira, Tony, Dinkova Kostova, Albena T. and Rizzarelli, Enrico (2008) Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity. Neurochemical Research, 33 (12). pp. 2444-2471. ISSN 0364-3190
Calabrese, Vittorio, Bates, Timothy E., Mancuso, Cesare, Cornelius, Carolin, Ventimiglia, Bernardo, Cambria, Maria Teresa, Di Renzo, Laura, De Lorenzo, Antonino and Dinkova-Kostova, Albena T. (2008) Curcumin and the cellular stress response in free radical-related diseases. Molecular Nutrition & Food Research, 52 (9). pp. 1062-1073. ISSN 1613-4125
Brooks, Keith J., Hargreaves, Iain P. and Bates, Timothy E. (2008) Protection of respiratory chain enzymes from ischaemic damage in adult rat brain slices. Neurochemical research, 33 (9). pp. 1711-1716. ISSN 0364-3190
Athanasiou, Andriani, Clarke, Anna B., Turner, Amy E., Kumaran, Nethia M., Vakilpour, Sara, Smith, Paul A., Bagiokou, Dimitra, Bradshaw, Tracey D., Westwell, Andrew D., Fang, Lin, Lobo, Dileep N., Constantinescu, Cris S., Calabrese, Vittorio, Loesch, Andrzej, Alexander, Stephen P. H., Clothier, Richard H., Kendall, David A. and Bates, Timothy E. (2007) Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications, 364 (1). pp. 131-137. ISSN 0006-291x
Mancuso, Cesare, Bates, Timothy E., Butterfield, D. Allan, Calafato, Stella, Cornelius, Carolin, De Lorenzo, Antonino, Dinkova Kostova, Albena T. and Calabrese, Vittorio (2007) Natural antioxidants in Alzheimer's disease. Expert Opinion on Investigational Drugs, 16 (12). pp. 1921-1931. ISSN 1354-3784
Abdel-Razaq, W., Bates, T. E. and Kendall, D. A. (2007) The effects of antidepressants on cyclic AMP-response element-driven gene transcription in a model cell system. Biochemical Pharmacology, 73 (12). pp. 1995-2003. ISSN 0006-2952
Athanasiou, Andriani, Smith, Paul A., Vakilpour, Sara, Kumaran, Nethia M., Turner, Amy E., Bagiokou, Dimitra, Layfield, Robert, Ray, David E., Westwell, Andrew D., Alexander, Stephen P. H., Kendall, David A., Lobo, Dileep N., Watson, Susan A., Lophatanon, Artitaya, Muir, Kenneth A., Guo, De-An and Bates, Timothy E. (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications, 354 (1). pp. 50-55. ISSN 0006-291X
Rosin, Claudia, Colombo, Sergio, Calver, Andrew A., Bates, Timothy E. and Skaper, Stephen D. (2005) Dopamine D2 and D3 receptor agonists limit oligodendrocyte injury caused by glutamate oxidative stress and oxygen/glucose deprivation. Glia, 52 (4). pp. 336-343. ISSN 0894-1491
Daley, E., Wilkie, D., Loesch, A., Hargreaves, I. P., Kendall, D. A., Pilkington, G. J. and Bates, T. E. (2005) Chlorimipramine: a novel anticancer agent with a mitochondrial target. Biochemical and Biophysical Research Communications, 328 (2). pp. 623-632. ISSN 0006-291X
Rosin, Claudia, Bates, Timothy E. and Skaper, Stephen D. (2004) Excitatory amino acid induced oligodendrocyte cell death in vitro: receptor-dependent and -independent mechanisms. Journal of Neurochemistry, 90 (5). pp. 1173-1185. ISSN 0022-3042
Cooper, Chris E., Davies, Nathan A., Psychoulis, Minas, Canevari, Laura, Bates, Tim E., Dobbie, Michael S., Casley, Christopher S. and Sharpe, Martyn A. (2003) Nitric oxide and peroxynitrite cause irreversible increases in the K(m) for oxygen of mitochondrial cytochrome oxidase: in vitro and in vivo studies. Biochimica et Biophysica Acta: general subjects, 1607 (1). pp. 27-34. ISSN 0006-3002
Levicar, Natasa, Dewey, Ricardo A., Daley, Emma, Bates, Timothy E., Davies, Derek, Kos, Janko, Pilkington, Geoffrey J. and Lah, Tamara T. (2003) Selective suppression of cathepsin L by antisense cDNA impairs human brain tumor cell invasion in vitro and promotes apoptosis. Cancer Gene Therapy, 10 (2). pp. 141-51. ISSN 0929-1903
Brooks, Keith J, Hargreaves, Iain, Bhakoo, Kishore, Sellwood, Mark, O'Brien, Francis, Noone, Martina, Sakata, Yasuko, Cady, Ernest, Wylezinska, Marzena, Thornton, John, Ordidge, Roger, Nguyen, Quyen, Clemence, Matthew, Wyatt, John and Bates, Timothy E. (2002) Delayed hypothermia prevents decreases in N-acetylaspartate and reduced glutathione in the cerebral cortex of the neonatal pig following transient hypoxia-ischaemia. Neurochemical Research, 27 (12). pp. 1599-604. ISSN 0364-3190
Kristián, Tibor, Weatherby, Tina M., Bates, Timothy E. and Fiskum, Gary (2002) Heterogeneity of the calcium-induced permeability transition in isolated non-synaptic brain mitochondria. Journal of Neurochemistry, 83 (6). pp. 1297-308. ISSN 0022-3042
Calabrese, Vittorio, Scapagnini, Giovanni, Ravagna, Agrippino, Bella, Rita, Foresti, Roberta, Bates, Timothy E., Giuffrida Stella, Anna-Maria and Pennisi, Giovanni (2002) Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels. Journal of Neuroscience Research, 70 (4). pp. 580-7. ISSN 0360-4012
Calabrese, V., Scapagnini, G., Giuffrida Stella, A. M., Bates, T. E. and Clark, J. B. (2001) Mitochondrial involvement in brain function and dysfunction: relevance to aging, neurodegenerative disorders and longevity. Neurochemical Research, 26 (6). pp. 739-64. ISSN 0364-3190
Sammut, Ivan A., Jayakumar, Jay, Latif, Najmi, Rothery, Stephen, Severs, Nicholas J., Smolenski, Ryszard T., Bates, Timothy E. and Yacoub, Magdi H. (2001) Heat stress contributes to the enhancement of cardiac mitochondrial complex activity. The American Journal of Pathology, 158 (5). pp. 1821-31. ISSN 0002-9440
Calabrese, V., Scapagnini, G., Catalano, C., Bates, T. E., Geraci, D., Pennisi, G. and Giuffrida Stella, A. M. (2001) Regulation of heat shock protein synthesis in human skin fibroblasts in response to oxidative stress: role of vitamin E. International Journal of Tissue Reactions, 23 (4). pp. 127-35. ISSN 0250-0868
Moss, David W. and Bates, Timothy E. (2001) Activation of murine microglial cell lines by lipopolysaccharide and interferon-gamma causes NO-mediated decreases in mitochondrial and cellular function. The European Journal of Neuroscience, 13 (3). pp. 529-38. ISSN 0953-816X
Calabrese, V., Scapagnini, G., Catalano, C., Dinotta, F., Bates, T. E., Calvani, M. and Stella, A. M. (2001) Effects of acetyl-L-carnitine on the formation of fatty acid ethyl esters in brain and peripheral organs after short-term ethanol administration in rat. Neurochemical Research, 26 (2). pp. 167-74. ISSN 0364-3190
Calabrese, V., Scapagnini, G., Catalano, C., Bates, T. E., Dinotta, F., Micali, G. and Giuffrida Stella, A. M. (2001) Induction of heat shock protein synthesis in human skin fibroblasts in response to oxidative stress: regulation by a natural antioxidant from rosemary extract. International Journal of Tissue Reactions, 23 (2). pp. 51-8. ISSN 0250-0868
Brooks, K. J., Hargreaves, I. P. and Bates, T. E. (2000) Nitric-oxide-induced inhibition of mitochondrial complexes following aglycaemic hypoxia in neonatal cortical rat brain slices. Developmental Neuroscience, 22 (5-6). pp. 359-65. ISSN 0378-5866
Calabrese, V., Bates, T. E. and Stella, A. M. (2000) NO synthase and NO-dependent signal pathways in brain aging and neurodegenerative disorders: the role of oxidant/antioxidant balance. Neurochemical Research, 25 (9-10). pp. 1315-41. ISSN 0364-3190
Kristián, Tibor, Gertsch, Jeff, Bates, Timothy E. and Siesjö, Bo K. (2000) Characteristics of the calcium-triggered mitochondrial permeability transition in nonsynaptic brain mitochondria: effect of cyclosporin A and ubiquinone O. Journal of Neurochemistry, 74 (5). pp. 1999-2009. ISSN 0022-3042
Calabrese, Vittorio, Testa, Guiseppe, Ravagna, Agrippino, Bates, Timothy Edward and Stella, Anna Maria (2000) HSP70 induction in the brain following ethanol administration in the rat: regulation by glutathione redox state. Biochemical and Biophysical Research Communications, 269 (2). pp. 397-400. ISSN 0006-291X
Canevari, Laura, Clark, John B. and Bates, Timothy E. (1999) Beta-amyloid fragment 25-35 selectively decreases complex IV activity in isolated mitochondria. FEBS Letters, 457 (1). pp. 131-4. ISSN 0014-5793
Kenyon, Susan H., Waterfield, Catherine J., Asker, Daniel S., Kudo, Mariko, Moss, David W., Bates, Timothy E., Nicolaou, Anna, Gibbons, William A. and Timbrell, John A. (1999) Effect of hydrazine upon vitamin B12-dependent methionine synthase activity and the sulphur amino acid pathway in isolated rat hepatocytes. Biochemical Pharmacology, 57 (11). pp. 1311-1319. ISSN 0006-2952
Keelan, Julie, Bates, Timothy E. and Clark, John B. (1999) Heightened resistance of the neonatal brain to ischemia-reperfusion involves a lack of mitochondrial damage in the nerve terminal. Brain research, 821 (1). pp. 124-33. ISSN 0006-8993
Canevari, Laura, Console, Antonella, Tendi, E. A., Clark, J. B. and Bates, Timothy (1999) Effect of postischaemic hypothermia on the mitochondrial damage induced by ischaemia and reperfusion in the gerbil. Brain research, 817 (1-2). pp. 241-245. ISSN 0006-8993
Brooks, K. J., Hargreaves, I. P., Clark, J. B. and Bates, Timothy (1998) Ischaemia-induced damage to mitochondrial complexes in the neonatal brain--role of NO. Biochemical Society Transactions, 26 (4). S343. ISSN 0300-5127
Brooks, Keith J., Clark, John B. and Bates, Timothy E. (1998) 3-Hydroxybutyrate aids the recovery of the energy state from aglycaemic hypoxia of adult but not neonatal rat brain slices. Journal of Neurochemistry, 70 (5). pp. 1986-1990. ISSN 0022-3042
Sammut, Ivan A., Thorniley, Maureen S., Simpkin, Sandra, Fuller, Barry J., Bates, Timothy E. and Green, Colin J. (1998) Impairment of hepatic mitochondrial respiratory function following storage and orthotopic transplantation of rat livers. Cryobiology, 36 (1). pp. 49-60. ISSN 0011-2240
Canevari, Laura, Kuroda, Satoshi, Bates, Timothy E., Clark, John B. and Siesjö, Bo K. (1997) Activity of mitochondrial respiratory chain enzymes after transient focal ischemia in the rat. Journal of Cerebral Blood Flow and Metabolism : official Journal of the International Society of Cerebral Blood Flow and Metabolism, 17 (11). pp. 1166-9. ISSN 0271-678X
Bakken, Inger J., Sonnewald, Ursula, Clark, John B. and Bates, Timothy E. (1997) [U-13C]glutamate metabolism in rat brain mitochondria reveals malic enzyme activity. Neuroreport, 8 (7). pp. 1567-1570. ISSN 0959-4965
Brooks, K. J., Clark, J. B. and Bates, T. E. (1996) Assessment of energy metabolism in the developing brain following aglycemic hypoxia by 1H and 31P NMR. Neurochemical Research, 21 (9). pp. 1089-1095. ISSN 0364-3190
Keelan, J., Brand, M. P., Bates, T. E., Land, J. M., Clark, J. B. and Heales, S. J. (1996) Nitric oxide and antioxidant status in glucose and oxygen deprived neonatal and adult rat brain synaptosomes. Neurochemical Research, 21 (8). pp. 923-7. ISSN 0364-3190
Keelan, Julie, Bates, Timothy E. and Clark, John B. (1996) Intrasynaptosomal free calcium concentration during rat brain development: effects of hypoxia, aglycaemia, and ischaemia. Journal of neurochemistry, 66 (6). pp. 2460-7. ISSN 0022-3042
Bates, Timothy E., Strangward, Maria, Keelan, Julia, Davey, Gavin P., Munro, Peter M. G. and Clark, John B. (1996) Inhibition of N-acetylaspartate production: implications for 1H MRS studies in vivo. Neuroreport, 7 (8). pp. 1397-1400. ISSN 0959-4965
Kuroda, Satoshi, Katsura, Ken-ichiro, Hillered, Lars, Bates, Timothy E. and Siesjö, Bo K. (1996) Delayed treatment with alpha-phenyl-N-tert-butyl nitrone (PBN) attenuates secondary mitochondrial dysfunction after transient focal cerebral ischemia in the rat. Neurobiology of Disease, 3 (2). pp. 149-157. ISSN 0969-9961
Bates, T. E., Loesch, A., Burnstock, G. and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochemical and biophysical research communications, 218 (1). pp. 40-44. ISSN 0006-291X
Bates, T. E, Loesch, A., Burnstock, G. and Clark, J. B. (1995) Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver. Biochemical and biophysical research communications, 213 (3). pp. 896-900. ISSN 0006-291X
Almeida, Angeles, Allen, Kathryn L., Bates, TImothy E. and Clark, John B. (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. Journal of neurochemistry, 65 (4). pp. 1698-1703. ISSN 0022-3042
Almeida, A., Brooks, K. J., Sammut, I., Keelan, J., Davey, G. P., Clark, J. B. and Bates, T. E. (1995) Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain. Developmental neuroscience, 17 (4). pp. 212-218. ISSN 0378-5866
Allen, Kathryn L., Almeida, Angeles, Bates, Timothy E. and Clark, John B. (1995) Changes of respiratory chain activity in mitochondrial and synaptosomal fractions isolated from the gerbil brain after graded ischaemia. Journal of neurochemistry, 64 (5). pp. 2222-2229. ISSN 0022-3042
Heales, S. J., Davies, S. E., Bates, T. E. and Clark, J. B. (1995) Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration. Neurochemical research, 20 (1). pp. 31-38. ISSN 0364-3190
Bates, T. E., Heales, S. J., Davies, S. E., Boakye, P. and Clark, J. B. (1994) Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. Journal of neurochemistry, 63 (2). pp. 640-648. ISSN 0022-3042
Dagnelie, Pieter C., Bell, Jimmy D., Williams, Steve C., Bates, Timothy E., Abel, Paul D. and Foster, Christopher S. (1994) Effect of fish oil on cancer cachexia and host liver metabolism in rats with prostate tumors. Lipids, 29 (3). pp. 195-203. ISSN 0024-4201
Clark, J B, Bates, Timothy, Cullingford, T and Land, J M (1993) Development of enzymes of energy metabolism in the neonatal mammalian brain. Developmental neuroscience, 15 (3-5). pp. 174-180. ISSN 0378-5866
Dagnelie, P. C., Bell, J. D., Williams, S. C., Bates, T. E., Abel, P. D. and Foster, C. S. (1993) Altered phosphorylation status, phospholipid metabolism and gluconeogenesis in the host liver of rats with prostate cancer: a 31P magnetic resonance spectroscopy study. British Journal of Cancer, 67 (6). pp. 1303-1309. ISSN 0007-0920
Gadian, D. G., Williams, S. R., Bates, T. E. and Kauppinen, R. A. (1993) NMR spectroscopy: current status and future possibilities. Acta neurochirurgica. Supplementum, 57 . pp. 1-8. ISSN 0065-1419
Murphy, Elizabeth J., Bates, Timothy E., Williams, Stephen R., Watson, Tracey, Brindle, Kevin M., Rajagopalan, Bheeshma and Radda, George K. (1992) Endoplasmic reticulum: the major contributor to the PDE peak in hepatic 31P-NMR spectra at low magnetic field strengths. Biochimica et biophysica acta: biomembranes, 1111 (1). pp. 51-58. ISSN 0005-2736
Rafter, Joan E., Bates, Timothy E., Bell, Jimmy D. and Iles, Richard A. (1991) Metabolites in the developing rat liver: a proton nuclear magnetic resonance spectroscopic study. Biochimica et biophysica acta: general subjects, 1074 (2). pp. 263-269. ISSN 0304-4165
Gadian, D. G., Bates, T. E., Williams, S. R., Bell, J. D., Austin, S. J. and Connelly, A. (1991) Approaches to editing, assignment and interpretation of proton spectra. NMR in biomedicine, 4 (2). pp. 85-89. ISSN 0952-3480
Bates, T. E., Williams, S. R., Gadian, D. G., Bell, J. D., Small, R. K. and Iles, R. A. (1989) 1H NMR study of cerebral development in the rat. NMR in biomedicine, 2 (5-6). pp. 225-229. ISSN 0952-3480
Brooks, K. J., Kauppinen, R. A., Williams, S. R., Bachelard, H. S., Bates, T. E. and Gadian, D. G. (1989) Ammonia causes a drop in intracellular pH in metabolizing cortical brain slices. A [31P]- and [1H]nuclear magnetic resonance study. Neuroscience, 33 (1). pp. 185-192. ISSN 0306-4522
Bates, Timothy E., Williams, Stephen R. and Gadian, David G. (1989) Phosphodiesters in the liver: the effect of field strength on the 31P signal. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 12 (1). pp. 145-150. ISSN 0740-3194
Bates, Timothy E., Williams, Stephen R., Kauppinen, Risto A. and Gadian, David G. (1989) Observation of cerebral metabolites in an animal model of acute liver failure in vivo: a 1H and 31P nuclear magnetic resonance study. Journal of neurochemistry, 53 (1). pp. 102-10. ISSN 0022-3042
Bates, T. E., Williams, S. R., Busza, A. L., Gadian, D. G. and Proctor, E. (1988) A 31P nuclear magnetic resonance study in vivo of metabolic abnormalities in rats with acute liver failure. NMR in biomedicine, 1 (2). pp. 67-73. ISSN 0952-3480
Cox, Jane, Bryant, David J., Ross, Brian D., Young, Ian R., Gadian, David G., Bydder, Graeme M., Williams, Stephen R., Busza, Albert L. and Bates, Timothy E. (1987) Spectral resolution in clinical magnetic resonance spectroscopy. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 5 (2). pp. 186-90. ISSN 0740-3194
Read, N. W., Al-Janabi, M. N., Bates, T. E., Holgate, A. M., Cann, P. A., Kinsman, R. I., McFarlane, A. and Brown, Christine (1985) Interpretation of the breath hydrogen profile obtained after ingesting a solid meal containing unabsorbable carbohydrate. Gut, 26 (8). pp. 834-842. ISSN 0017-5749
Read, N. W., McFarlane, A., Kinsman, R. I., Bates, T. E., Blackhall, N. W., Farrar, G. B., Hall, J. C., Moss, G., Morris, A. P., O'Neill, B., Welch, I., Lee, Y. and Bloom, S. R. (1984) Effect of infusion of nutrient solutions into the ileum on gastrointestinal transit and plasma levels of neurotensin and enteroglucagon. Gastroenterology, 86 (2). pp. 274-280. ISSN 0016-5085
Read, N. W., Al Janabi, M. N., Bates, T. E. and Barber, D. C. (1983) Effect of gastrointestinal intubation on the passage of a solid meal through the stomach and small intestine in humans. Gastroenterology, 84 (6). pp. 1568-1572. ISSN 0016-5085