Generation in vivo of peptide-specific cytotoxic T cells and presence of regulatory T cells during vaccination with hTERT (class I and II) peptide-pulsed DCs

Aloysius, Mark M., Mc Kechnie, Alastair J., Robins, Richard A., Verma, Chandan, Eremin, Jennifer M., Farzaneh, Farzin, Habib, Nagy A, Bhalla, Joti, Hardwick, Nicola R., Satthaporn, Sukchai, Sreenivasan, Thiagarajan, El-Sheemy, Mohammed and Eremin, Oleg (2009) Generation in vivo of peptide-specific cytotoxic T cells and presence of regulatory T cells during vaccination with hTERT (class I and II) peptide-pulsed DCs. Journal of Translational Medicine, 7 (1). p. 18. ISSN 1479-5876

Full content URL: http://dx.doi.org/10.1186/1479-5876-7-18

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Item Type:Article
Item Status:Live Archive

Abstract

Optimal techniques for DC generation for immunotherapy in cancer are yet to be established. Study aims were to evaluate: (i) DC activation/maturation milieu (TNF-α +/- IFN-α) and its effects on CD8+ hTERT-specific T cell responses to class I epitopes (p540 or p865), (ii) CD8+ hTERT-specific T cell responses elicited by vaccination with class I alone or both class I and II epitope (p766 and p672)-pulsed DCs, prepared without IFN-α, (iii) association between circulating T regulatory cells (Tregs) and clinical responses.

Keywords:Immunotherapy, Cancer immunotherapy
Subjects:B Subjects allied to Medicine > B100 Anatomy, Physiology and Pathology
Divisions:College of Science > School of Life Sciences
ID Code:9797
Deposited On:10 Jun 2013 09:00

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