Annexins in human breast cancer: possible predictors of pathological response to neoadjuvant chemotherapy

Chuthapisith, Suebwong, Bean, Beverley E., Cowley, Gerard, Eremin, Jennifer M., Samphao, Srila, Layfield, Robert, Kerr, Ian D., Wiseman, Janice, El-Sheemy, Mohamed, Sreenivasan, Thiagarajan and Eremin, Oleg (2009) Annexins in human breast cancer: possible predictors of pathological response to neoadjuvant chemotherapy. European Journal of Cancer, 45 (7). pp. 1274-1281. ISSN 0959-8049

Full content URL: http://dx.doi.org/10.1016/j.ejca.2008.12.026

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Item Type:Article
Item Status:Live Archive

Abstract

Neoadjuvant chemotherapy is used in women who have large or locally advanced breast cancers. However, up to 70% of women who receive neoadjuvant chemotherapy fail to achieve a complete pathological response in their primary tumour (a surrogate marker of long-term survival). Five proteins, previously identified to be linked with chemoresistance in our in vitro experiments, were identified histochemically in pre-treatment core needle biopsies from 40 women with large or locally advanced breast cancers. Immunohistochemical staining with the five proteins showed no single protein to be a predictor of response to chemotherapy. However, pre-treatment breast cancer specimens that were annexin-A2 positive but annexin-A1 negative correlated with a poor pathological response (p = 0.04, Fisher’s exact test). The mechanisms by which annexins confer chemoresistance have not been identified, but may be due to inhibition of apoptosis. Annexin-A1 has been shown to enhance apoptosis, whilst annexin-A2, by contrast, inhibits apoptosis

Keywords:Breast cancer, Neoadjuvant chemotherapy, Annexin-A1, Annexin-A2, Pathological response
Subjects:B Subjects allied to Medicine > B130 Pathology
Divisions:College of Science > School of Life Sciences
ID Code:9796
Deposited On:10 Jun 2013 08:48

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