Sequence analysis of the non-structural 3A and 3C protein-coding regions of foot-and-mouth disease virus serotype Asia1 field isolates from an endemic country.

Biswas, S., Sanyal, A., Hemadri, D., Tosh, C., Mohapatra, J. K., Kumar, R. Manoj and Bandyopadhyay, S. K. (2006) Sequence analysis of the non-structural 3A and 3C protein-coding regions of foot-and-mouth disease virus serotype Asia1 field isolates from an endemic country. Veterinary Microbiology, 116 (1-3). pp. 187-193. ISSN 0378-1135

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Item Type:Article
Item Status:Live Archive

Abstract

A total of 18 foot-and-mouth disease virus (FMDV) serotype Asia1 field isolates belonging to two different lineages (including the divergent group) as delineated earlier in VP1-based phylogeny were sequenced in the non-structural 3A and 3C protein-coding regions. The phylogenetic trees representing the regions coding for the non-structural proteins were very similar to that of the structural VP1 protein-coding region. Phylogenetic comparison at 3C region revealed clustering of Asia1 viruses with the isolates of serotypes O, A and C in the previously identified clade. Comparison of amino acid sequences identified lineage-specific signature residues in both the non-structural proteins. Overall analysis of the amino acid substitutions revealed that the 3A coding region was more prone to amino acid alterations than 3C region.

Keywords:Virology, veterinary medicine, Animal Diseases, Microbiology, RNA virus, Molecular phylogenetics
Subjects:C Biological Sciences > C520 Medical and Veterinary Microbiology
C Biological Sciences > C440 Molecular Genetics
Divisions:College of Science > School of Life Sciences
ID Code:9373
Deposited On:10 May 2013 10:13

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