Accumulation and intracellular fate of tellurite in tellurite-resistant Escherichia coli: a model for the mechanism of resistance

Lloyd-Jones, Gareth, Osborn, A. Mark, Ritchie, Donald A., Strike, Peter, Hobman, Jon L., Brown, Nigel L. and Rouch, Duncan A. (1994) Accumulation and intracellular fate of tellurite in tellurite-resistant Escherichia coli: a model for the mechanism of resistance. FEMS Microbiology Letters, 118 (1-2). pp. 113-119. ISSN 0378-1097

Full content URL: http://dx.doi.org/10.1111/j.1574-6968.1994.tb06812...

Full text not available from this repository.

Item Type:Article
Item Status:Live Archive

Abstract

The tellurite accumulation properties of three Escherichia coli strains containing different tellurium-resistance determinants of Gram-negative origin, from plasmids pMER610, pHH1508a and RK2, were compared. In all three cases membrane-associated tellurium crystallization was observed, and neither reduced uptake nor increased export contributed to the resistance. Specific membrane-proximal reduction is proposed as the mechanism of resistance to tellurite coded by all three determinants, despite their lack of sequence homology.

Keywords:tellurite, unclassified drug, article, drug resistance, escherichia coli, nonhuman, priority journal, toxicity, Crystallization, Drug Resistance, Microbial, Models, Biological, Oxidation-Reduction, Plasmids, Support, Non-U.S. Gov't, Tellurium
Subjects:C Biological Sciences > C180 Ecology
C Biological Sciences > C500 Microbiology
Divisions:College of Science > School of Life Sciences
Related URLs:
ID Code:8978
Deposited On:06 May 2013 19:16

Repository Staff Only: item control page