Davey, R. J., Blagden, N., Potts, G. D. and Docherty, R. (1997) Polymorphism in molecular crystals: stabilization of a metastable form by conformational mimicry. Journal of the American Chemical Society, 119 (7). pp. 1767-1772. ISSN 0002-7863
Full content URL: http://dx.doi.org/10.1021/ja9626345
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| Item Type: | Article |
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| Item Status: | Live Archive |
Abstract
A combined modeling and experimental strategy has been applied to the problem of stabilisation of a metastable conformational polymorph. For the first time additives have been successfully selected which by virtue of their conformation are able to selectively inhibit the appearance of the stable β polymorph of L-glutamic acid and hence stabilize the metastable α structure.
| Additional Information: | Publication Date (Web): February 19, 1997 |
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| Keywords: | glutamic acid, article, crystallography, drug stability, drug structure, protein polymorphism |
| Subjects: | B Subjects allied to Medicine > B200 Pharmacology, Toxicology and Pharmacy |
| Divisions: | College of Science > School of Pharmacy |
| Related URLs: | |
| ID Code: | 8783 |
| Deposited On: | 03 Apr 2013 13:56 |
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