Davey, R. J., Blagden, N., Righini, S. , Alison, H. and Ferrari, E. S. (2002) Nucleation control in solution mediated polymorphic phase transformations: the case of 2,6-dihydroxybenzoic acid. Journal of Physical Chemistry B, 106 (8). pp. 1954-1959. ISSN 1520-6106
Full content URL: http://dx.doi.org/10.1021/jp013044i
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| Item Type: | Article |
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| Item Status: | Live Archive |
Abstract
This contribution describes the kinetics of the solution mediated phase transformation between forms 1 and 2 of dihydroxybenzoic acid. It is shown how a combination of kinetic, morphological, and modeling data can be used to give a full description of the rate-determining process in such a transformation. Surprisingly, secondary nucleation is found to dominate the kinetic processes. Such a phenomenon is well-known in continuous crystallization but is reported here for the first time in a polymorphic phase transformation. This observation has significant consequences for process and product control in the pharmaceutical and specialty chemicals industries.
| Keywords: | Polymorphic modifications, Carboxylic acids, Computer simulation, Crystallization, Drug products plants, Nucleation, Phase transitions, Reaction kinetics |
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| Subjects: | B Subjects allied to Medicine > B200 Pharmacology, Toxicology and Pharmacy |
| Divisions: | College of Science > School of Pharmacy |
| Related URLs: | |
| ID Code: | 8774 |
| Deposited On: | 26 Jul 2013 14:21 |
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