Solubility of salbutamol and salbutamol sulphate in ethanol + water mixtures at 25°c

Ali, H. S. M., York, P., Blagden, Nicholas , Khoubnasabjafari, M., Acree Jr., W. E. and Jouyban, A. (2012) Solubility of salbutamol and salbutamol sulphate in ethanol + water mixtures at 25°c. Journal of Molecular Liquids, 173 . pp. 62-65. ISSN 0167-7322

Full content URL: http://dx.doi.org/10.1016/j.molliq.2012.05.021

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Abstract

Experimental solubilities of salbutamol and salbutamol sulphate in ethanol + water mixtures at 25 °C are reported. The solubility of salbutamol was found to increase with the addition of ethanol, and reached a maximum value at an ethanol volume fraction of 0.8. The solubility of salbutamol sulphate decreased with increasing ethanol concentration, and reached a minimum value in ethanol. The Jouyban-Acree model correlated the measured salbutamol and salbutamol sulphate solubility data to within mean relative deviations (MRD) of 3.4 and 13.4, respectively. Solubilities were predicted using previously trained models developed for crystalline non-electrolyte and electrolyte solutes. The trained models for non-electrolytes and electrolytes produced the prediction MRDs of 22.4 and 19.8, respectively. Crown Copyright © 2012 Published by Elsevier B.V. All rights reserved.

Keywords:Ethanol concentrations, Jouyban-Acree model, Maximum values, Minimum value, Relative deviations, Salbutamol, Solubility data, Sulphates, Water mixture, Electrolytes, Ethanol, Solubility
Subjects:F Physical Sciences > F100 Chemistry
Divisions:College of Science > School of Computer Science
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ID Code:8745
Deposited On:04 Apr 2013 08:49

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