Erythrocyte morphology and haemoglobin types of neonatal roan antelopes (Hippotragus equinus) with hypochromic poikilocytic anaemia

Parsons, S. D. C., Penzhorn, B. L., Reyers, Fred, Steyl, J. C. A. and Becker, P. J. (2006) Erythrocyte morphology and haemoglobin types of neonatal roan antelopes (Hippotragus equinus) with hypochromic poikilocytic anaemia. Journal of Comparative Pathology, 134 (2-3). pp. 152-160. ISSN 0021-9975

Full content URL: http://dx.doi.org/10.1016/j.jcpa.2005.09.008

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Item Type:Article
Item Status:Live Archive

Abstract

Neonatal, poikilocytic anaemia in some members of the Hippotragini has previously been documented but not fully investigated. This study was undertaken to describe the erythrocyte morphology of roan antelopes (Hippotragus equinus) during the first 4 weeks after birth and to identify aspects of haemoglobin (Hb) production that might be implicated in this syndrome. Twenty-nine roan antelope calves were sampled on, or close to, 1, 7, 14 and 28 days after birth. Erythrocyte morphology was characterized, and microhaematocrit values and Hb parameters determined, for each sampling occasion. Findings indicated a significant change in erythrocyte morphology during the neonatal period and two haemoglobin types, fetal and adult, were identified. The perinatal onset of adult Hb synthesis was delayed relative to the termination of fetal Hb production, resulting in the observed anaemia. Haemoglobin concentration and erythrocyte morphology were significantly correlated. These findings suggest an intimate relationship between Hb synthesis and the observed poikilocytosis. An imbalance in the synthesis of the α- and �-globin chains of Hb (a thalassaemia) may prove to be the underlying pathophysiology of this syndrome. © 2005 Elsevier Ltd. All rights reserved.

Keywords:alpha globin, beta globin, hemoglobin, anemia, animal cell, animal disease, antelope, article, cell structure, correlation analysis, electrophoresis, erythrocyte, hematocrit, hematology, hemoglobin synthesis, newborn, nonhuman, pathophysiology, thalassemia, Anemia, Hemolytic, Congenital, Anemia, Hypochromic, Animal Diseases, Animals, Animals, Newborn, Antelopes, Chromatography, High Pressure Liquid, Erythrocyte Indices, Erythrocytes, Abnormal, Fetal Hemoglobin, Animalia, Hippotragus, Hippotragus equinus
Divisions:College of Science > School of Life Sciences
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ID Code:8443
Deposited On:31 Mar 2013 19:05

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