Time-resolved nanoseconds dynamics of ultrasound contrast agent microbubbles manipulated and controlled by optical tweezers

Garbin, Valeria, Cojoc, Dan, Ferrari, Enrico, Di Fabrizio, Enzo, Overelde, Marlies, Versluis, Michel, van der Meer, Sander, de Jong, Nico and Lohse, Detlef (2006) Time-resolved nanoseconds dynamics of ultrasound contrast agent microbubbles manipulated and controlled by optical tweezers. In: Optical Trapping and Optical Micromanipulation III, 13 August 2006, San Diego, California.

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Item Type:Conference or Workshop contribution (Paper)
Item Status:Live Archive

Abstract

Optical tweezers enable non-destructive, contact-free manipulation of ultrasound contrast agent (UCA) microbubbles, which are used in medical imaging for enhancing the echogenicity of the blood pool and to quantify organ perfusion. The understanding of the fundamental dynamics of ultrasound-driven contrast agent microbubbles is a first step for exploiting their acoustical properties and to develop new diagnostic and therapeutic applications. In this respect, optical tweezers can be used to study UCA microbubbles under controlled and repeatable conditions, by positioning them away from interfaces and from neighboring bubbles. In addition, a high-speed imaging system is required to record the dynamics of UCA microbubbles in ultrasound, as their oscillations occur on the nanoseconds timescale. In this work, we demonstrate the use of an optical tweezers system combined with a high-speed camera capable of 128-frame recordings at up to 25 million frames per second (Mfps), for the study of individual UCA microbubble dynamics as a function of the distance from solid interfaces.

Keywords:Ultrasounds
Subjects:F Physical Sciences > F310 Applied Physics
Divisions:College of Science > School of Life Sciences
ID Code:8400
Deposited On:27 Mar 2013 20:04

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