Abstract

.Obtaining information on the metabolic fate of a drug in humans is a key requirement in drug development. Of the various metabolic (pharmacokinetic) parameters such as half-life and clearance, absolute bioavailability is one parameter that is not routinely measured. Although some data on the bioavailability of new drugs has to be submitted as part of the drug approval process, pharmaceutical companies may not necessarily perform a full absolute bioavailability study in humans in every case.