An efficient entry to 1,2-benzisoxazoles via 1,3-dipolar cycloaddition of in situ generated nitrile oxides and benzyne

Spiteri, Christian, Mason, Christopher, Zhang, Fengzhi , Ritson, Dougal J., Sharma, Pallavi, Keeling, Steve and Moses, John E. (2010) An efficient entry to 1,2-benzisoxazoles via 1,3-dipolar cycloaddition of in situ generated nitrile oxides and benzyne. Organic and Biomolecular Chemistry Articles, 8 (11). pp. 2537-2542. ISSN 1477-0520

Full content URL: http://pubs.rsc.org/en/content/articlelanding/2010...

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Item Type:Article
Item Status:Live Archive

Abstract

An efficient protocol for the synthesis of a range of 1,2-benzisoxazoles using an improved 1,3-dipolar cycloaddition of nitrile oxides and benzyne is described. Key to the procedure is the in situ generation of the reactive nitrile oxide and benzyne reactants simultaneously.

Additional Information:An efficient protocol for the synthesis of a range of 1,2-benzisoxazoles using an improved 1,3-dipolar cycloaddition of nitrile oxides and benzyne is described. Key to the procedure is the in situ generation of the reactive nitrile oxide and benzyne reactants simultaneously.
Keywords:Benzisoxazole, benzyne, 1, 3-dipolar cycloaddition
Subjects:F Physical Sciences > F160 Organic Chemistry
Divisions:College of Science > School of Life Sciences
ID Code:7108
Deposited On:21 Dec 2012 14:49

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