Macdonald, James M., Tarling, Chris A., Taylor, Edward J. , Dennis, Rebecca J., Myers, David S., Knapp, Spencer, Davies, Gideon J. and Withers, Stephen G. (2010) Chitinase inhibition by chitobiose and chitotriose thiazolines. Angewandte Chemie, 49 (14). pp. 2599-2602. ISSN 0044-8249
Full content URL: http://dx.doi.org/10.1002/anie.200906644
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| Item Type: | Article |
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| Item Status: | Live Archive |
Abstract
A good imitation: Di- and trisaccharide analogues of the oxazoline intermediate formed during enzymatic hydrolysis of chitin were found to be potent inhibitors of chitinase A. The high affinity and enzymatic stability of a readily synthesized thioamide trisaccharide (two molecules of which are shown in the enzyme active site), and the mechanism-based mode of inhibition, make this analogue a promising candidate for broad-spectrum chitinase inhibition.
| Keywords: | carbohydrates;enzyme inhibitors;fungicides;insecticides;thiazolines |
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| Subjects: | C Biological Sciences > C790 Molecular Biology, Biophysics and Biochemistry not elsewhere classified |
| Divisions: | College of Science > School of Life Sciences |
| ID Code: | 6121 |
| Deposited On: | 07 Sep 2012 21:14 |
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