Large area high-resolution CCD-based X-ray detector for macromolecular crystallography

Pokric, Maja, Allinson, Nigel M., Jorden, A. R. , Cox, M. P., Marshall, A., Long, P. G., Moon, K., Jerram, P., Pool, P., Nave, C., Derbyshire, G. E. and Helliwell, J. R. (2002) Large area high-resolution CCD-based X-ray detector for macromolecular crystallography. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 477 . pp. 166-171. ISSN 0168-9002

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Abstract

An X-ray detector system for macromolecular crystallography based on a large area charge-coupled device (CCD)
sensor has been developed as part of a large research and development programme for advanced X-ray sensor
technology, funded by industry and the Particle Physics and Astronomy Research Council (PPARC) in the UK. The
prototype detector consists of two large area three-sides buttable charge-coupled devices (CCD 46-62 EEV), where
the single CCD area is 55.3mm41.5 mm. Overall detector imaging area is easily extendable to 85mm110 mm. The
detector consists of an optically coupled X-ray sensitive phosphor, skewed fibre-optic studs and CCDs. The
crystallographic measurement requirements at synchrotron sources are met through a high spatial resolution
(20481536 pixel array), high dynamic range (B105), a fast readout (B1 s), low noise (o10e) and much reduced
parallax error. Additionally, the prototype detector system has been optimised by increasingits efficiency at low X-ray
energies for use at conventional lab sources. The system design of the prototype detector is discussed and the proposed
method for crystallographic data processing is briefly outlined.

Additional Information:An X-ray detector system for macromolecular crystallography based on a large area charge-coupled device (CCD) sensor has been developed as part of a large research and development programme for advanced X-ray sensor technology, funded by industry and the Particle Physics and Astronomy Research Council (PPARC) in the UK. The prototype detector consists of two large area three-sides buttable charge-coupled devices (CCD 46-62 EEV), where the single CCD area is 55.3mm41.5 mm. Overall detector imaging area is easily extendable to 85mm110 mm. The detector consists of an optically coupled X-ray sensitive phosphor, skewed fibre-optic studs and CCDs. The crystallographic measurement requirements at synchrotron sources are met through a high spatial resolution (20481536 pixel array), high dynamic range (B105), a fast readout (B1 s), low noise (o10e) and much reduced parallax error. Additionally, the prototype detector system has been optimised by increasingits efficiency at low X-ray energies for use at conventional lab sources. The system design of the prototype detector is discussed and the proposed method for crystallographic data processing is briefly outlined.
Keywords:Data processing, Detector optimisation
Subjects:F Physical Sciences > F131 Crystallography
Divisions:College of Science > School of Computer Science
ID Code:4906
Deposited On:18 Feb 2012 14:05

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