Virologic response to efavirenz-based first-line antiretroviral therapy in children with previous exposure to antiretrovirals to prevent mother-to-child transmission

Menéndez-Arias, Luis, Nyakato, Patience, Davies, Mary-Ann , Technau, Karl-Gunter, Fatti, Geoffrey, Rabie, Helena, Tanser, Frank, Boulle, Andrew, Wood, Robin, Eley, Brian, Sawry, Shobna, Giddy, Janet, Sipambo, Nosisa, Kuhn, Louise and Fairlie, Lee (2020) Virologic response to efavirenz-based first-line antiretroviral therapy in children with previous exposure to antiretrovirals to prevent mother-to-child transmission. PLoS ONE, 15 (5). e0233693. ISSN 1932-6203

Full content URL: https://doi.org/10.1371/journal.pone.0233693

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Virologic response to efavirenz-based first-line antiretroviral therapy in children with previous exposure to antiretrovirals to prevent mother-to-child transmission
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Abstract

Efavirenz-based first-line regimens have been widely used for children ≥3 years of age starting antiretroviral therapy, despite possible resistance with prior exposure to non-nucleoside reverse transcriptase inhibitors for prevention of mother-to-child transmission (PMTCT). We used logistic regression to examine the association between PMTCT exposure and viral failure (VF) defined as two consecutive viral loads (VL)>1000 copies/ml between 6–18 months on ART. Children with previous nevirapine exposure for PMTCT were not at higher risk of VF compared to unexposed children (adjusted Odds Ratio (aOR): 0.79; 95% CI:0.56, 1.11).

Keywords:Antiretroviral therapy, Infants, Children, Immune suppression, Pediatrics, HIV, Medical risk factors, Protease inhibitor therapy
Subjects:A Medicine and Dentistry > A300 Clinical Medicine
Divisions:College of Social Science
ID Code:41621
Deposited On:23 Jul 2020 14:06

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