Structural Similarity in Chiral-Achiral Multi-Component Crystals

Munshi, Tasnim, Scowen, Ian, Seaton, Colin and Alomar, Taghrid (2020) Structural Similarity in Chiral-Achiral Multi-Component Crystals. CrystEngComm . ISSN 1466-8033

Full content URL: https://doi.org/10.1039/D0CE00301H

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Structural similarity in chiral-achiral multi-component crystals
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Abstract

The creation of multi-component crystals between chiral and achiral components has gained increased interest in recent years. In many cases the overall crystal structure is similar with the creation of a pseudo-inversion centre in the enantiopure case. This allows for the formation of solid solutions between the two extremes, which may have applications within chiral resolution. Utilising a combination of database mining, computational prediction and experimental screening, the frequency of formation for such materials has been investigated showing that for co-crystals this occurs more frequently than for salts, though there is a limited number of samples to draw structural conclusions. Computational modelling indicates the prediction of such systems can be challenging due to the similarities in energy of many crystal structures, so development of tools to design such systems is required to fully utilise these concepts

Keywords:CSD, chiral-achiral, multi-component crystals
Subjects:F Physical Sciences > F100 Chemistry
Divisions:College of Science > School of Chemistry
ID Code:40631
Deposited On:06 May 2020 13:10

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