Photosensitizer doped zeolitic imidazolate framework-8 nanocomposites for combined antibacterial therapy to overcome methicillin-resistant Staphylococcus aureus (MRSA)

Munshi, Tasnim, Ashna, Gopal, Sena, Karaosmanoglu , Jiafu, Lin, Wenjun, Zhang, Xianfeng, Chem and Li, Yan (2020) Photosensitizer doped zeolitic imidazolate framework-8 nanocomposites for combined antibacterial therapy to overcome methicillin-resistant Staphylococcus aureus (MRSA). Colloids and Surfaces B: Biointerfaces, 190 . p. 110900. ISSN 0927-7765

Full content URL: https://doi.org/10.1016/j.colsurfb.2020.110900

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Photosensitizer doped zeolitic imidazolate framework-8 nanocomposites for combined antibacterial therapy to overcome methicillin-resistant Staphylococcus aureus (MRSA)
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Abstract

Antibiotics have played an important role in the treatment of bacteria related infections. However, the rapid emergence of multidrug-resistant bacteria and limited number of antibiotics available is a great challenge to humankind. To circumvent the use of antibiotics and hence, address this problem, we are proposing a photosensitizer-modified biodegradable zeolitic imidazolate framework-8 nanocomposite that can kill not only Gram-positive bacteria Staphylococcus aureus, but also methicillin-resistant Staphylococcus aureus with high efficacy. In vivo testing revealed that these nanocomposites are highly effective for in vivo wound disinfection with minimal side-effects. In conclusion, this photosensitizer-modified biodegradable nanocomposite could be very promising for a synergistic antibacterial therapy to overcome methicillin-resistant Staphylococcus aureus (MRSA).

Keywords:zeolitic imidazolate framework 8, photosensitizer, photodynamic therapy, antibacterial therapy
Subjects:F Physical Sciences > F100 Chemistry
Divisions:College of Science
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ID Code:40537
Deposited On:08 Apr 2020 13:59

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