Novel Approaches to Drug Development by Applications of Accelerator Mass Spectrometry

Young, Graeme (2016) Novel Approaches to Drug Development by Applications of Accelerator Mass Spectrometry. PhD thesis, University of Lincoln.

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Novel Approaches to Drug Development by Applications of Accelerator Mass Spectrometry
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Young, Graeme C - Pharmaceutical Science - December 2016.pdf - Whole Document

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Item Type:Thesis (PhD)
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Abstract

Accelerator Mass Spectrometry (AMS) is an extremely sensitive nuclear physics isotope
ratio technique with growing application to clinical pharmaceutical drug development.
The papers discussed in this commentary demonstrate a wide variety of clinical study
designs that incorporate the use of radiocarbon (
14C) as a tracer, with subsequent
analysis by AMS. The focus of the commentary is application of AMS as an enabling
technique aimed towards novel investigations of the absorption, distribution,
metabolism, excretion and pharmacokinetics (ADME-PK) of new therapeutic drugs in
humans. The impact and contributions to this field of research are demonstrated
through discussion and critical examination of selected examples of the author’s peerreviewed publications in this area. The first use of AMS in a clinical study for a new
drug in development is included, along with other ADME-PK studies with potential new
medicines. The commentary details the expanding scope of AMS over recent years to
encompass experiments designed to yield previously unattainable data.
Developments of scientific practices, where the author has contributed intellectual,
leadership and practical insight to achieve significant improvements in the generation
of knowledge, are highlighted throughout the commentary. The ongoing and future
development of AMS, as well as the emergence of techniques as potential alternatives
to AMS to provide deep insight into the research of new medicines are also discussed.

Divisions:College of Science
ID Code:37657
Deposited On:04 Oct 2019 15:01

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