Formulation optimization of reverse microemulsions using design of experiments for nanoparticles synthesis

Nourafkan, Ehsan, Gao, Hui, Hu, Zhongliang and Dongsheng, Wen (2017) Formulation optimization of reverse microemulsions using design of experiments for nanoparticles synthesis. chemical engineering research and design, 125 . pp. 367-384. ISSN 0263-8762

Full content URL: https://doi.org/10.1016/j.cherd.2017.07.023

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Formulation optimization of reverse microemulsions using design of experiments for nanoparticles synthesis
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Abstract

tThe present work investigates the development of water/mixed nonionic surfactant/co-surfactant/cyclohexane reverse microemulsions (RM) suitable for nanoparticles synthesis.The mixture of Span 80 (oil soluble) and Tween 80 (water soluble) was selected as thesurfactants. Optimum formulation of RM was obtained by using the Box–Behnken (33) exper-imental design method to evaluate the effect of three independent process variables, i.e.,pH, Span 80 wt% in surfactant mixture, and propyl alcohol wt% in mixture of cyclohexaneand propyl alcohol, on the preferred responses: average droplet size (ADS) and polydisper-sity index (PDI) of droplets. The model was validated experimentally based on an ANOVAtable, and was optimized to reach the optimum formulation to yield the ADS and PDI forRMs. The determination coefficient (R2) values of 0.991 for ADS and 0.975 for PDI show thatBox–Behnken design is a useful platform for the optimization of RMs formulation. Finally,iron oxide nanoparticles were synthesized under the optimum RM conditions and the uni-form nanoparticle distribution with an average particle size of 2.1 ± 0.49 nanometer and apolydispersity of 0.06 ± 0.011 were obtained.

Keywords:Reverse microemulsions, Span80/Tween80
Subjects:H Engineering > H800 Chemical, Process and Energy Engineering
Divisions:College of Science > School of Mathematics and Physics
ID Code:36947
Deposited On:10 Sep 2019 08:16

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