Saving bones without risking brain—bisphosphonates and risk of stroke: matched case-control study

Asghar, Zahid, Godoy Caballero, Ana Luisa, Pathirannehelage, S., Williams, J., McKay, Steve, Grassby, Paul, de Lusignan, S. and Siriwardena, Niro (2019) Saving bones without risking brain—bisphosphonates and risk of stroke: matched case-control study. Osteoporosis International, 30 (9). pp. 1845-1854. ISSN 0937-941X

Full content URL:

Saving bones without risking brain—bisphosphonates and risk of stroke: matched case-control study
Author's Accepted Manuscript
[img] PDF
Bisphosphonatesandstroke_OsteoInt_Revised_Final.pdf - Whole Document
Restricted to Repository staff only until 17 June 2020.

Item Type:Article
Item Status:Live Archive


There is conflicting evidence on the link between bisphosphonates and stroke with studies variously showing increased, decreased or unchanged risk. We investigated the association between bisphosphonate treatment and the risk of stroke using a large routine clinical dataset.
We used a matched nested case-control study design analysing routinely collected electronic data from patients registered at primary care practices in England participating in the Royal College of General Practitioners Research and Surveillance Centre. Cases were patients aged 18 years or over, either living or dead, recorded as having had a stroke in the period 1st January 2005 to March 31st 2016. Each case was matched to one control according to age, sex, general practice attended and calendar time. Data were analysed using Stata, version 14.2. Conditional logistic regression was used to determine odds ratios for stroke according to bisphosphonate treatment and duration in cases compared with controls. We adjusted for disease risk groups, cardiovascular risk factors, treatments, smoking status, alcohol consumption, ethnicity , bisphosphonate types, fracture and socioeconomic status using IMD (Index of Multiple Deprivation).
We included 31,414 cases of stroke with an equal number of matched controls. Overall, 83.2% of cases and controls were aged 65 years or older and there were similar proportions of females (51.5%) and males (48.5%). Bisphosphonate treatment was not associated with stroke after adjusting for the wide range of confounders considered (OR 0.86, 95% CI 0.62 - 1.19).
We found no association between bisphosphonate treatment and risk of stroke, after adjusting for other confounders.

Keywords:Bisphosphonates, Stroke, Fracture, ONJ, Nested Matched Case Control study, Electronic Clinical-Patient Dataset.
Subjects:A Medicine and Dentistry > A400 Clinical Dentistry
C Biological Sciences > C110 Applied Biology
A Medicine and Dentistry > A300 Clinical Medicine
B Subjects allied to Medicine > B200 Pharmacology, Toxicology and Pharmacy
Divisions:College of Social Science > School of Health & Social Care
Related URLs:
ID Code:36316
Deposited On:27 Jun 2019 08:32

Repository Staff Only: item control page