PRaVDA: The First Solid-State System for Proton Computed Tomography

Esposito, Michela, Waltham, Chris, Allinson, Nigel , Taylor, Jon, Manger, Sam, Phoenix, Ben, Price, Tony, Poludniowski, Gavin, Green, Stuart, Evans, Phil, Allport, Phil, Manolopulos, Spyros, Nieto-Camero, Jaime and Symons, Julyan (2018) PRaVDA: The First Solid-State System for Proton Computed Tomography. Journal of Physica Medica, 55 . pp. 149-154. ISSN 1120-1797

Full content URL: https://doi.org/10.1016/j.ejmp.2018.10.020

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PRaVDA: The First Solid-State System for Proton Computed Tomography
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Abstract

Proton CT is widely recognised as a beneficial alternative to con- ventional X-ray CT for treatment planning in proton beam radiotherapy. A novel proton CT imaging system, based entirely on solid-state detec- tor technology, is presented. Compared to conventional scintillator-based calorimeters, positional sensitive detectors allow for multiple protons to be tracked per read out cycle, leading to a potential reduction in proton CT scan time. Design and characterisation of its components are discussed. An early proton CT image obtained with a fully solid-state imaging sys- tem is shown and accuracy (as defined in Section IV) in Relative Stopping Power to water (RSP) quantified.
A solid-state imaging system for proton CT, based on silicon strip detectors, has been developed by the PRaVDA collaboration. The sys- tem comprises a tracking system that infers individual proton trajecto- ries through an imaging phantom, and a Range Telescope (RT) which records the corresponding residual energy (range) for each proton. A back-projection-then-filtering algorithm is used for CT reconstruction of an experimentally acquired proton CT scan.
An initial experimental result for proton CT imaging with a fully solid-state system is shown for an imaging phantom, namely a 75 mm diameter PMMA sphere containing tissue substitute inserts,imaged with a passively-scattered 125 MeV beam. Accuracy in RSP is measured to be ≤1.6% for all the inserts shown.
A fully solid-state imaging system for proton CT has been shown capable of imaging a phantom with protons and successfully improving RSP accuracy. These promising results, together with system the capabil- ity to cope with high proton fluences (2×108 protons/s), suggests that this research platform could improve current standards in treatment planning for proton beam radiotherapy.

Keywords:proton CT, proton therapy, medical physics
Subjects:F Physical Sciences > F350 Medical Physics
Divisions:College of Science
ID Code:33999
Deposited On:07 Nov 2018 12:53

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