McCafferty, Cian, Connelly, William M., Celli, Roberta , Ngomba, Richard T., Nicoletti, Ferdinando and Crunelli, Vincenzo (2018) Genetic rescue of absence seizures. CNS Neuroscience & Therapeutics . ISSN 1755-5930
Full content URL: http://doi.org/10.1111/cns.12858
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31998 Genetic rescue of absence seizures_To_Repository.pdf - Whole Document Available under License Creative Commons Attribution 4.0 International. 317kB |
| Item Type: | Article |
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| Item Status: | Live Archive |
Abstract
Crossbreeding GABAAR δ subunit knockout mice with stargazer mice removes the absence seizure phenotype
Thalamic tonic GABAA current is similarly abolished
Rescue also occurs with acute siRNA knockdown of δ subunit
Ataxic phenotype of stargazer is partially ameliorated
| Keywords: | Seizures, Genetics |
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| Subjects: | C Biological Sciences > C431 Medical Genetics |
| Divisions: | College of Science > School of Chemistry |
| ID Code: | 31998 |
| Deposited On: | 08 May 2018 09:22 |
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