Genetic rescue of absence seizures

McCafferty, Cian, Connelly, William M., Celli, Roberta , Ngomba, Richard T., Nicoletti, Ferdinando and Crunelli, Vincenzo (2018) Genetic rescue of absence seizures. CNS Neuroscience & Therapeutics . ISSN 1755-5930

Full content URL: http://doi.org/10.1111/cns.12858

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Abstract

Crossbreeding GABAAR δ subunit knockout mice with stargazer mice removes the absence seizure phenotype
Thalamic tonic GABAA current is similarly abolished
Rescue also occurs with acute siRNA knockdown of δ subunit
Ataxic phenotype of stargazer is partially ameliorated

Keywords:Seizures, Genetics
Subjects:C Biological Sciences > C431 Medical Genetics
Divisions:College of Science > School of Chemistry
ID Code:31998
Deposited On:08 May 2018 09:22

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