Trapping of normal EB1 ligands in aggresomes formed by an EB1 deletion mutant

Riess, Nicholas, Milward, Kelly, Lee, Tracy, Adams, Matthew, Askham, Jon M and Morrison, Ewan E (2005) Trapping of normal EB1 ligands in aggresomes formed by an EB1 deletion mutant. BMC Cell Biology, 6 (1). p. 17. ISSN 1471-2121

Full content URL: http://doi.org/10.1186/1471-2121-6-17

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Trapping of normal EB1 ligands in aggresomes formed by an EB1 deletion mutant
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Abstract

EB1 is a microtubule tip-associated protein that interacts with the APC tumour suppressor protein and the p150glued subunit of dynactin. We previously reported that an EB1 deletion mutant that retains both of these interactions but does not directly associate with microtubules (EB1-ΔN2-GFP) spontaneously formed perinuclear aggregates when expressed in COS-7 cells.

Keywords:Aggresomes, EB1, Microtubules
Subjects:C Biological Sciences > C130 Cell Biology
Divisions:College of Science > School of Chemistry
ID Code:31319
Deposited On:23 Jul 2018 14:32

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