Dynamic data-driven finite element models for laser treatment of cancer

Oden, J. T., Diller, K. R., Bajaj, C., Browne, J.C., Hazle, J., Babuška, I., Bass, J., Bidaut, L., Demkowicz, L., Elliott, A., Feng, Y., Fuentes, D., Prudhomme, S., Rylander, M. N., Stafford, R. J. and Zhang, Y. (2007) Dynamic data-driven finite element models for laser treatment of cancer. Numerical Methods for Partial Differential Equations, 23 (4). pp. 904-922. ISSN 0749-159X

Full content URL: http://doi.org/10.1002/num.20251

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Item Type:Article
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Abstract

Elevating the temperature of cancerous cells is known to increase their susceptibility to subsequent radiation or chemotherapy treatments, and in the case in which a tumor exists as a well-defined region, higher intensity heat sources may be used to ablate the tissue. These facts are the basis for hyperthermia based cancer treatments. Of the many available modalities for delivering the heat source, the application of a laser heat source under the guidance of real-time treatment data has the potential to provide unprecedented control over the outcome of the treatment process (McNichols et al., Lasers Surg Med 34 (2004), 48–55; Salomir et al., Magn Reson Med 43 (2000), 342–347). The goals of this work are to provide a precise mathematical framework for the real-time finite element solution of the problems of calibration, optimal heat source control, and goal-oriented error estimation applied to the equations of bioheat transfer and demonstrate that current finite element technology, parallel computer architecture, data transfer infrastructure, and thermal imaging modalities are capable of inducing a precise computer controlled temperature field within the biological domain. © 2007 Wiley Periodicals, Inc. Numer Methods Partial Differential Eq 23: 904–922, 2007

Additional Information:The final published version of this article can be accessed online at https://onlinelibrary.wiley.com/doi/abs/10.1002/num.20251
Keywords:laser treatments of cancer, data-driven, finite element models
Subjects:F Physical Sciences > F350 Medical Physics
Divisions:College of Science > School of Computer Science
ID Code:29489
Deposited On:13 Aug 2018 13:46

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