Cutsuridis, Vassilis (2014) Bradykinesia models. In: Encyclopedia of computational neuroscience. Springer. ISBN 9781461473206
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Cut2013EncyclopediaCompNeurosci.pdf - Chapter Restricted to Repository staff only 163kB |
Item Type: | Book Section |
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Item Status: | Live Archive |
Abstract
Bradykinesia is the cardinal symptom of Parkinson’s disease (PD). It is related to an abnormal
slowness of movement. The causes of PD bradykinesia are not known largely, because there are
multiple brain areas and pathways involved from the neuronal degeneration site (dopamine
neurons in substantia nigra pars compacta (SNc) and ventral tegmental area (VTA)) to the muscles.
Bradykinesia models are mathematical and computational constructs attempting to uncover how
information is processed in the affected brain areas and what are the biophysical mechanisms
giving rise to the observed slowness of movement in PD bradykinesia.
Keywords: | computational neuroscience |
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Subjects: | B Subjects allied to Medicine > B140 Neuroscience |
Divisions: | College of Science > School of Computer Science |
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ID Code: | 28787 |
Deposited On: | 29 Sep 2017 10:26 |
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