High rates of congenital cytomegalovirus infection linked with maternal HIV infection among neonatal admissions at a large referral center in sub-Saharan Africa

Mwaanza, Nyaxewo, Chilukutu, Lophina, Tembo, John, Kabwe, Mwila, Musonda, Kunda, Kapasa, Monica, Chabala, Chishala, Sinyangwe, Sylvester, Mwaba, Peter, Zumla, Alimuddin and Bates, Matthew (2014) High rates of congenital cytomegalovirus infection linked with maternal HIV infection among neonatal admissions at a large referral center in sub-Saharan Africa. Clinical Infectious Diseases, 58 (5). pp. 728-735. ISSN 1058-4838

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Abstract

Background. Congenital cytomegalovirus (CMV) infection is the major infectious cause of birth defects and hearing loss globally. There is a growing recognition of the potential clinical impact of congenital CMV infections in high-seroprevalence settings. Methods. A cross-sectional study of neonatal admissions at a large referral center in sub-Saharan Africa to determine the prevalence of both symptomatic and asymptomatic congenital CMV infection was performed. Real-time polymerase chain reaction was used to screen DNA-extracted sera, urine, and saliva, and an enzyme-linked immunosorbent assay was used to screen serum samples for anti-CMV immunoglobulin M. Multivariate binary logistic regression was used to identify risk factors associated with increased odds of congenital CMV infection. Results. Congenital CMV was detected in 3.8% (15/395) of neonates. Among these infants, 6 of 15 (40%) presented with jaundice, 1 of whom also had petechiae. Congenital CMV infection was detected in 9 of 79 (11.4%; 95% confidence interval CI], 6.1%-20.3%) neonates born to human immunodeficiency virus (HIV)-infected mothers, and both maternal HIV (odds ratio OR], 6.661 95% CI, 2.126-20.876], P = .001) and jaundice (OR, 5.701 95% CI, 1.776-18.306], P = .003) were independently linked with significantly increased odds of congenital CMV infection. Conclusions. Congenital and early infant CMV infections may have important consequences for child health in sub-Saharan Africa and other high HIV and CMV seroprevalence populations globally.

Keywords:congenita, CMV, HIV, Africa, neonate}
Subjects:A Medicine and Dentistry > A300 Clinical Medicine
Divisions:College of Science > School of Life Sciences
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ID Code:28380
Deposited On:16 Mar 2018 16:30

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