The development, evaluation and performance of molecular diagnostics for detection of Mycobacterium tuberculosis

Bates, Matthew and Zumla, Alimuddin (2016) The development, evaluation and performance of molecular diagnostics for detection of Mycobacterium tuberculosis. Expert Review of Molecular Diagnostics, 16 (3). pp. 307-322. ISSN 1473-7159

Documents
Bates Zumla Expert Review TB Diagnostics.pdf

Request a copy
[img] PDF
Bates Zumla Expert Review TB Diagnostics.pdf - Whole Document
Restricted to Repository staff only

1MB
Item Type:Article
Item Status:Live Archive

Abstract

The unique pathogenesis of tuberculosis (TB) poses several barriers to the development of accurate diagnostics: a) the establishment of life-long latency by Mycobacterium tuberculosis (M.tb) after primary infection confounds the development of classical antibody or antigen based assays; b) our poor understanding of the molecular pathways that influence progression from latent to active disease; c) the intracellular nature of M.tb infection in tissues means that M.tb and/or its components, are not readily detectable in peripheral specimens; and d) the variable presence of M.tb bacilli in specimens from patients with extrapulmonary TB or children. The literature on the current portfolio of molecular diagnostics tests for TB is reviewed here and the developmental pipeline is summarized. Also reviewed are data from recently published operational research on the GeneXpert MTB/RIF assay and discussed are the lessons that can be taken forward for the design of studies to evaluate the impact of TB diagnostics.

Keywords:Tuberculosi, Molecular Diagnostics, Xpert, smear microscopy, biomarker, WHO}
Subjects:A Medicine and Dentistry > A300 Clinical Medicine
Divisions:College of Science > School of Life Sciences
Related URLs:
ID Code:28356
Deposited On:07 Nov 2017 15:54

Repository Staff Only: item control page