Lujo viral hemorrhagic fever: considering diagnostic capacity and preparedness in the wake of recent Ebola and Zika virus outbreaks

Simulundu, Edgar, Mweene, Aaron S., Changula, Katendi, Monze, Mwaka, Chizema, Elizabeth, Mwaba, Peter, Takada, Ayato, Ippolito, Guiseppe, Kasolo, Francis, Zumla, Alimuddin and Bates, Matthew (2016) Lujo viral hemorrhagic fever: considering diagnostic capacity and preparedness in the wake of recent Ebola and Zika virus outbreaks. Reviewsin Medical Virology, 26 (6). pp. 446-454. ISSN 1052-9276

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Abstract

Lujo virus is a novel Old World arenavirus identified in Southern Africa in 2008 as the cause of a viral hemorrhagic fever (VHF) characterized by nosocomial transmission with a high case fatality rate of 80% (4/5 cases). Whereas this outbreak was limited, the unprecedented Ebola virus disease outbreak in West Africa, and recent Zika virus disease epidemic in the Americas, has brought into acute focus the need for preparedness to respond to rare but potentially highly pathogenic outbreaks of zoonotic or arthropod-borne viral infections. A key determinant for effective control of a VHF outbreak is the time between primary infection and diagnosis of the index case. Here, we review the Lujo VHF outbreak of 2008 and discuss how preparatory measures with respect to developing diagnostic capacity might be effectively embedded into existing national disease control networks, such as those for human immunodeficiency virus, tuberculosis, and malaria.

Keywords:Arenavirida, diagnostic capacity, Ebola virus disease, lessons, Lujo virus, Mammarenavirus, preparedness, viral hemorrhagic fever, Zika virus}
Subjects:A Medicine and Dentistry > A300 Clinical Medicine
Divisions:College of Science > School of Life Sciences
ID Code:28348
Deposited On:06 Sep 2017 14:35

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