The role of mammalian target of rapamycin (mTOR) in the regulation of pancreatic β-cell mass: Implications in the development of type-2 diabetes

Xie, J. and Herbert, T.P. (2012) The role of mammalian target of rapamycin (mTOR) in the regulation of pancreatic β-cell mass: Implications in the development of type-2 diabetes. Cellular and Molecular Life Sciences, 69 (8). pp. 1289-1304. ISSN 1420-682X

Full content URL: https://link.springer.com/article/10.1007/s00018-0...

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Item Type:Article
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Abstract

Type-2 diabetes mellitus (T2DM) is a disorder that is characterized by high blood glucose concentration in the context of insulin resistance and/or relative insulin deficiency. It causes metabolic changes that lead to the damage and functional impairment of organs and tissues resulting in increased morbidity and mortality. It is this form of diabetes whose prevalence is increasing at an alarming rate due to the ‘obesity epidemic’, as obesity is a key risk factor in the development of insulin resistance. However, the majority of individuals who have insulin resistance do not develop diabetes due to a compensatory increase in insulin secretion in response to an increase in insulin demand. This adaptive response is sustained by an increase in both β-cell function and mass. Importantly, there is increasing evidence that the Serine/Threonine kinase mammalian target of rapamycin (mTOR) plays a key role in the regulation of β-cell mass and therefore likely plays a critical role in β-cell adaptation. Therefore, the primary focus of this review is to summarize our current understanding of the role of mTOR in stimulating pancreatic β-cell mass and thus, in the prevention of type-2 diabetes.

Additional Information:The final published version of this article can be accessed online at: https://link.springer.com/article/10.1007/s00018-011-0874-4
Keywords:Type 2 diabetes, obesity, B-cell mass, m-TOR, TSC, Rheb, S6K, PKB, AMPK, RIKTOR
ID Code:28222
Deposited On:25 Jul 2018 11:24

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