Comparison of 1-year outcome in patients with severe aorta stenosis treated conservatively or by aortic valve replacement or by percutaneous transcatheter aortic valve implantation (data from a multicenter Spanish registry)

González-Saldivar, Hugo, Rodriguez-Pascual, Carlos, de la Morena, Gonzalo, Fernández-Golfín, Covadonga, Amorós, Carmen, Alonso, Mario Baquero, Dolz, Luis Martínez, Solé, Albert Ariza, Guzmán-Martínez, Gabriela, Gómez-Doblas, Juan José, Jiménez, Antonio Arribas, Fuentes, María Eugenia, Gay, Laura Galian, Ortiz, Martin Ruiz, Avanzas, Pablo, Abu-Assi, Emad, Ripoll-Vera, Tomás, Díaz-Castro, Oscar, Osinalde, Eduardo P., Martínez-Sellés, Manuel, Saldivar, Hugo González, Rodriguez-Pascual, Carlos, Parajes-Vazquez, Teresa, Montero-Magan, Marina, De la Morena, Gonzalo, Flores-Blanco, Pedro J., Fernández-Golfín, Covadonga, Lozano, Cristina, Rincón, Luis Miguel, Amorós, Carmen, Borras, Xavier, Alonso, Mario Baquero, Camacho, Eva García, Pérez, Andrés Sánchez, Dolz, Luis Martínez, Climent, Herminio Morillas, Sánchez, Jorge Sanz, Vallverdú, María Ferré, Solé, Albert Ariza, Guzmán-Martínez, Gabriela, González-Fernández, Óscar, Gómez-Doblas, Juan José, Jiménez, Antonio Arribas, Garcia Sánchez, Maria Jesús, Sánchez Fernandez, Pedro Luis, Fuentes, María Eugenia, Millán, María Victoria, Gay, Laura Galian, Ortiz, Martin Ruiz, Avanzas, Pablo, Pascual, Isaac, Morís, César, Abu-Assi, Emad, Vera, Tomás Ripoll, Pérez, Yolanda Gómez, Diaz-Castro, Oscar, Borreguero, Jesús Jimenez, Pozo, Eduardo, Antuña, Paula, Viliani, Dafne, Mogollón Jiménez, María Victoria, Gómez, Gonzalo Marcos, García, Marcelino Cortés, Orejas, Miguel Orejas, Quiles, Juan, Gunturiz, Clara, Castrodeza, Javier, Tobar, Javier, López, Javier, Garcia Gonzalez, Martin Jesús, Labrador, Eva Bernal, Ayerbe, Jorge López, Barros, Sonia María, Ruiz, Antoni Carol, Botas, Javier, García, Alberto Núñez, Girgas, Esther Sanz, Ruiz, Alfredo Bardají, Caro Martinez, Cesar S., Aguera, Alicia Gómez, Sierra, Teresa Pareja, Yarcuri, Fiorella Quinte, Rodriguez, Irene Mateo, Martínez, Maria del Pilar Zuazola, Pérez, Teresa, Arrarte Esteban, Vicente Ignacio, Garri, Francisco Sogorb, Ramirez-Marrero, Miguel A., Campaña, Sonia Ibars, Marchan, Ferrán Padilla, Rodríguez-Capitán, Jorge, Andion, Ramón, de Isla, Leopoldo Pérez, Casado, Patricia Mahía, Carrera, José Plaza, de la Villa Redondo, Bernardo García, Valencia-Serrano, Félix M., Bustos, Daniel Bravo, Lacambra-Blasco, Isaac, Isasti, Guillermo, Paves, Alicia Bautista, Pereyra, Eduardo, Pueo, Eva, Santos, Luis Cornide, Martín, Ana Garrido, Lozano, Clara Bonanad, Diaz, Javier Lopez, Calvo, Javier Castrodeza, Ruiz, Javier Tobar and Martínez-Sellés, Manuel (2016) Comparison of 1-year outcome in patients with severe aorta stenosis treated conservatively or by aortic valve replacement or by percutaneous transcatheter aortic valve implantation (data from a multicenter Spanish registry). American Journal of Cardiology, 118 (2). pp. 244-250. ISSN 0002-9149

Full content URL: http://dx.doi.org/10.1016/j.amjcard.2016.04.044

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Abstract

The factors that influence decision making in severe aortic stenosis (AS) are unknown. Our aim was to assess, in patients with severe AS, the determinants of management and prognosis in a multicenter registry that enrolled all consecutive adults with severe AS during a 1-month period. One-year follow-up was obtained in all patients and included vital status and aortic valve intervention (aortic valve replacement [AVR] and transcatheter aortic valve implantation [TAVI]). A total of 726 patients were included, mean age was 77.3 ± 10.6 years, and 377 were women (51.8%). The most common management was conservative therapy in 468 (64.5%) followed by AVR in 199 (27.4%) and TAVI in 59 (8.1%). The strongest association with aortic valve intervention was patient management in a tertiary hospital with cardiac surgery (odds ratio 2.7, 95% confidence interval 1.8 to 4.1, p <0.001). The 2 main reasons to choose conservative management were the absence of significant symptoms (136% to 29.1%) and the presence of co-morbidity (128% to 27.4%). During 1-year follow-up, 132 patients died (18.2%). The main causes of death were heart failure (60% to 45.5%) and noncardiac diseases (46% to 34.9%). One-year survival for patients treated conservatively, with TAVI, and with AVR was 76.3%, 94.9%, and 92.5%, respectively, p <0.001. One-year survival of patients treated conservatively in the absence of significant symptoms was 97.1%. In conclusion, most patients with severe AS are treated conservatively. The outcome in asymptomatic patients managed conservatively was acceptable. Management in tertiary hospitals is associated with valve intervention. One-year survival was similar with both interventional strategies.

Keywords:Aotic stenosis, TAVI, Treatment, elderly, NotOAChecked
Subjects:A Medicine and Dentistry > A300 Clinical Medicine
Divisions:College of Science > School of Pharmacy
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ID Code:27708
Deposited On:05 Jul 2017 11:45

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