Does abnormal spinal reciprocal inhibition lead to co-contraction of antagonist motor units? A modelling study

Cutsuridis, Vassilis (2007) Does abnormal spinal reciprocal inhibition lead to co-contraction of antagonist motor units? A modelling study. International Journal of Neural Systems, 17 (04). pp. 319-327. ISSN 0129-0657

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Abstract

It is suggested that co-contraction of antagonist motor units perhaps due to abnormal disynaptic Ia reciprocal
inhibition is responsible for Parkinsonian rigidity. A neural model of Parkinson’s disease bradykinesia
is extended to incorporate the effects of spindle feedback on key cortical cells and examine the effects
of dopamine depletion on spinal activities. Simulation results show that although reciprocal inhibition is
reduced in DA depleted case, it doesn’t lead to co-contraction of antagonist motor neurons. Implications
to Parkinsonian rigidity are discussed.

Keywords:Parkinson's disease, Dopamine, reciprocal inhibition, spinal cord, rigidity, Neural model
Subjects:G Mathematical and Computer Sciences > G730 Neural Computing
Divisions:College of Science > School of Computer Science
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ID Code:27635
Deposited On:21 Jun 2017 14:09

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